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2016 News


das Institut sucht laufend motivierte Mitarbeiter (PhD, Post-Doc). Aussagefähige Bewerbungen erwünscht.





OPA1 functionally interacts with MIC60 but is dispensable for crista junction formation.

Barrera M, Koob S, Dikov D, Vogel F, Reichert AS.

FEBS Lett. 2016 Sep 1. doi: 10.1002/1873-3468.12384. [Epub ahead of print]


Mic13 Is Essential for Formation of Crista Junctions in Mammalian Cells

Ruchika Anand, Valentina Strecker, Jennifer Urbach, Ilka Wittig, Andreas S. Reichert

Research Article | published 01 Aug 2016 PLOS ONE



Controlling quality and amount of mitochondria by mitophagy: insights into the role of ubiquitination and deubiquitination.

Tan T, Zimmermann M, Reichert AS.

Biol Chem. 2016 Jul 1;397(7):637-47. doi: 10.1515/hsz-2016-0125.




Hodgkin and Reed-Sternberg cells of classical Hodgkin lymphoma are highly dependent on oxidative phosphorylation. Birkenmeier K, Dröse S, Wittig I, Winkelmann R, Käfer V, Döring C, Hartmann S, Wenz T, Reichert AS, Brandt U, Hansmann ML.Int J Cancer. 2015 Nov 23. doi: 10.1002/ijc.29934. [Epub ahead of print]; PMID:26595876


Data supporting the role of the non-glycosylated isoform of MIC26 in determining cristae morphology

Link to Elsevier article Koob et al. 2015


Mitophagy and deubiquitination in yeast - the power of synthetic quantitative array technology

Link to Molecular & Cellular Oncology article Behrendt et al. 2015


The Redox Code

Link to Antioxid Redox Signal article Jones et al. 2015


The non-glycosylated isoform of MIC26 is a constituent of the mammalian MICOS complex and promotes formation of crista junctions

Link to Biochimica et Biophysica Acta article Koob et al. 2015


Mitophagy and mitochondrial dynamics in Saccharomyces cerevisiae

Link to Biochimica et Biophysica Acta article Müller et al. 2015


Synthetic Quantitative Array Technology Identifies the Ubp3-Bre5 Deubiquitinase Complex as a Negative Regulator of Mitophagy

We have developed a method, termed synthetic quantitative array technology, to screen for mitophagy modulators in yeast. Using this method we identified the Ubp3-Bre5 deubiquitination complex, which inhibits mitophagy but promotes other types of autophagy. Deubiquitination thus appears to regulate a switch between distinct autophagy pathways.

Link to Cell Reports article Müller et al. 2015


Simultaneous impairment of mitochondrial fission and fusion reduces mitophagy and shortens replicative lifespan

We show that balanced mitochondrial dynamics and not a filamentous mitochondrial morphotype per se plays a key factor for ensuring long lifespan. Our study demonstrates a cross-talk between two different mitochondrial quality control pathways: mitophagy and mitochondrial dynamics.

Link to Scientific Reports article Bernhard et al. 2015



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