Publications

V. Börger, D. Rottke, U. R. Sorg, S. Heikaus, J. Hatina, B. Möhlendick, B. Opalka, B. Hildebrandt, Z. Özcan, L. Pack, W. A. Schulz, P. Wernet, R. Ackermann, and R. V. Sorg. Identification of metastasising cancer stem cell-like cells of type I papillary renal cell carcinoma. Br J Canc, manuscript submitted 

Honke N, Shaabani N, Cadeddu G, Sorg UR, Zhang DE, Trilling M, Klingel K, Sauter M, Kandolf R, Gailus N, van Rooijen N, Burkart C, Baldus SE, Grusdat M, Löhning M, Hengel H, Pfeffer K, Tanaka M, Häussinger D, Recher M, Lang PA, Lang KS. Enforced viral replication activates adaptive immunity and is essential for the control of a cytopathic virus. Nat Immunol (2011), 20;13:51-57

*Giordano FA, *Sorg UR, Appelt JU, Lachmann N, Bleier S, Roeder I, Kleff V, Flasshove M, Zeller WJ, Allgayer H, von Kalle C, Fruehauf S, Moritz T, Laufs S. Clonal inventory screens uncover monoclonality following serial transplantation of MGMT P140K-transduced stem cells and dose-intense chemotherapy. Hum Gene Ther (2011), 22:697-710  (*joint first authorship)

Kleff V, Sorg UR, Bury C, Rattmann I, Poremba C, Flasshove M, Opalka B, Dirksen U, Moritz T. Gene Therapy of βc-deficient Pulmonary Alveolar Proteinosis (βc-PAP): Studies in a Murine in vivo Model. Mol Therapy (2008), 16:757-764

Dürig J, Ebeling P, Grabellus F, Sorg UR, Möllmann M, Schütt P, Göthert J, Sellmann L, Flasshove M, Seeber S, Dührsen U, Moritz T (2007) A novel Nonobese diabetic/Severe Combined Immunodeficient Xenograft Model for Chronic Lymphocytic Leukemia Reflects Important Clinical Characteristics of the Disease. Cancer Research, 2007,  67:8653-866

Sorg UR, Kleff V, Fanaei S, Schumann A, Moellmann M, Opalka B, Thomale J, Moritz T (2007) O6-methylguanine-DNA-methyltransferase (MGMT) gene therapy targeting haematopoietic stem cells: Studies addressing safety issues. DNA Repair, 6:1197-1209

Rattmann I, Kleff V, Feldmann, A, Ludwig L, Sorg UR, Opalka B, Moritz T, Flasshove M (2007) Reliable generation of high titer stable producer cell lines for gene therapy. Intervirology, 50:197-203

Ebeling P, Bach P, Sorg U, Schneider A, Trarbach T, Schneider H, Dilloo D, Hanenberg H, Niesert S, Seeber S, Moritz T, Flasshove M (2007) Evaluation of different protocols for gene transfer into non-obese diabetes/severe combined immunodeficiency disease mouse repopulating cells. J Cancer Res Clin Oncol, 133(3):199-209

Rattmann I, Kleff V, Sorg UR, Bardenheuer W, Brueckner A, Hilger RA, Opalka B, Seeber S, Flasshove M, Moritz T (2006) Gene transfer of cytidine deaminase protects myelopoiesis from cytidine analogs in an in vivo murine transplant model. Blood, 108(9):2965-71

Bracker TU, Giebel B, Spanholtz J, Sorg U, Klein-Hitpass L, Moritz T, Thomale J (2006) Stringent regulation of DNA repair during human hematopoietic differentiation: a gene expression and functional analysis. Stem Cells 24:722-730

Bardenheuer W, Lehmberg K, Rattmann I, Brueckner A, Schneider A, Sorg UR, Seeber S, Moritz T, Flasshove M (2005) Resistance to cytarabine and gemcitabine and in vitro selection of transduced cells after retroviral expression of cytidine deaminase in human hematopoietic progenitor cells. Leukemia 19: 2281-2288

Meisel R, Bardenheuer W, Strehblow C, Sorg UR, Elmaagacli A, Seeber S, Flasshove M, Moritz T (2003) Efficient protection from methotrexate toxicity and selection of transduced human hematopoietic cells following gene transfer of dihydrofolate reductase mutants. Exp Hematol 31: 1215-1222

Jansen M, Sorg UR, Ragg S, Flasshove M, Seeber S, Williams DA, Moritz T (2002) Hematoprotection and enrichment of transduced cells in vivo after gene transfer of MGMTP140K into hematopoietic stem cells. Cancer Gene Ther 9: 737-746

Jansen M, Bardenheuer W, Sorg UR, Seeber, S, Flasshove M, Moritz T (2001) Protection of hematopoietic cells from O6-alkylation damage by O6-methylguanine DNA-methyltransferase gene transfer: studies with different O6-alkylating agents and retroviral backbonesEur J Haematol 67: 2-13

Hart DN, Clark GJ, Dekker JW, Fearnley DB, Kato M, Hock BD, McLellan AD, Neil T, Sorg RV, Sorg U, Summers KL,  Vukovic S (1997)Dendritic cell surface molecules. A proliferating fieldAdv. Exp Med Biol 417:439-442

Sorg UR, Morse TM, Patton WN, Hock BD, Angus HB, Robinson BA, Colls BM, Hart, D. Hodgkin’s cells express CD83, a dendritic cell lineage associated antigen. (1997)Pathology 29:294.299 

Sorg RV, Enczmann J, Sorg UR, Schneider EM, Wernet P (1993) Identification of an alternatively spliced transcript of human interleukin-4 lacking the sequence encoded by exon 2. Exp Hematol 21:560-563

Sorg UR, Enczmann J, Sorg RV, Wernet P (1992) One-step molecular HLA-DR prescreening employing a set of 14 sequence specific oligonucleotides in a non-radioactive tetramethylammonium chloride hybridization protocol. Eur J Immunogen 19:391-401

Sorg U, Enczmann J, Sorg R, and Wernet P. Rapid non-radioactive TMACl hybridization protocol employing enzymatically labeled oligonucleotides. (1992) Nucl Acids Res 19:4782, 1992

Sorg R, Enczmann J, Sorg U, Heermeier K, Schneider EM, and Wernet P (1991)Rapid and sensitive mRNA phenotyping for interleukins (IL-1 to IL-6) and colony-stimulating factors (G-, M-, GM-CSF) by reverse transcription and subsequent polymerase chain reaction. Exp Hematol 19:882-887

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