Molecular Infectious Immunology
Our scientific interest is centered on the cytokines - messenger molecules of the immune system - involved in the defense against infections with viral, bacterial, and eukaryotic pathogens. The cytokine family of type I interferons are of special importance as they can be functionally placed at the interface between innate and adaptive immune responses. Also, type I interferons – and amongst these most prominently IFNβ - have been shown to be critically involved in the development of autoimmune diseases like Multiple Sclerosis. Due to a lack in the availability of sufficiently sensitive methods, the identity and functional characteristics of type I interferon producing cells is still widely unknown. We recently generated a fluorescence basedβ reporter “knock-in” mouse that expresses YFP from a bicistronic transcript under the control of the endogenous control elements inside the ifnb gene. This novel genetic mouse model for the first time allows for the visualization of IFNβ producing cells – and simultaneously their cellular or microbial interaction partners - and the definition of their functional roles in complex immunological disease models in vivo. An additional field of research in the lab is the analysis of the immunological functions of members of the tumour necrosis factor (TNF) superfamily. Currently studies on single or multiple gene-deficient mouse models are underway focussing on the role of LIGHT and HVEM in differentiation and activation of innate immune cell populations like granulocytes or monocytes and their functional roles in bacterial infection models like Listeria monocytogenes.Findings from these studies are of high value in the development of new approaches for immune therapies and vaccination strategies for infections and autoimmune diseases.
Wir haben innerhalb unseres Forschungsbereichs zur Zeit mehrere Masterarbeiten und Diplomarbeiten für Biologen, Biochemiker etc., sowie Doktorarbeiten für Mediziner mit Interesse am immunbiologischen experimentellen Arbeiten zu vergeben.
Bitte richten Sie Ihre Anfragen direkt an Prof. Stefanie Scheu.
updated August 27th 2012