Publications Group Stahl

2020

Stucki D, Steinhausen J, Westhoff P, Krahl H, Brilhaus D, Massenberg A, Weber APM, Reichert AS, Brenneisen P, Stahl W. Endogenous carbon monoxide signaling modulates mitochondrial function and intracellular glucose utilization: Impact of the heme oxigenase substrate hemin. Antioxidants 2020, 9(8), 652; doi.org/10.3390/antiox9080652. PMID: 32717801.

Stucki D, Krahl H, Walter M, Steinhausen J, Hommel K, Brenneisen P, Stahl W. Effects of frequently applied carbon monoxide releasing molecules (CORMs) in typical CO-sensitive model systems - A comparative in vitro study. Arch Biochem Biophys. 2020 Apr 23;687:108383. doi: 10.1016/j.abb.2020.108383. PMID: 32335048.

Aplak E, von Montfort C, Haasler L, Stucki D, Steckel B, Reichert AS, Stahl W, Brenneisen P. CNP mediated selective toxicity on melanoma cells is accompanied by mitochondrial dysfunction. PLoS One. 2020 Jan 17;15(1):e0227926. doi: 10.1371/journal.pone.0227926. PMID: 31951630.

2019

Berning L, Scharf L, Aplak E, Stucki D, von Montfort C, Reichert AS, Stahl W, Brenneisen P. In vitro selective cytotoxicity of the dietary chalcone cardamonin (CD) on melanoma compared to healthy cells is mediated by apoptosis. PLoS One. 2019 Sep 25;14(9):e0222267. doi: 10.1371/journal.pone.0222267. eCollection 2019. PMID: 31553748.

Walter M, Stahl W, Brenneisen P, Reichert AS, Stucki D. Carbon monoxide releasing molecule 401 (CORM-401) modulates phase I metabolism of xenobiotics. Toxicol In Vitro. 2019 Apr 17; 59:215-220. doi: 10.1016/j.tiv.2019.04.018. PMID: 31004742.

2018

Stucki D, Brenneisen P, Reichert AS, Stahl W. The BH3 mimetic compound BH3I-1 impairs mitochondrial dynamics and promotes stress response in addition to its pro-apoptotic key function. Toxicol Lett. 2018 Oct 1;295:369-378. doi: 10.1016/j.toxlet.2018.07.017. Epub 2018 Jul 18. PMID: 30031050.

Decroix L, Tonoli C, Lespagnol E, Balestra C, Descat A, Drittij-Reijnders MJ, Blackwell JR, Stahl W, Jones AM, Weseler AR, Bast A, Meeusen R, Heyman E. One-week cocoa flavanol intake increases prefrontal cortex oxygenation at rest and during moderate-intensity exercise in normoxia and hypoxia. J Appl Physiol (1985). 2018 Jul 1;125(1):8-18. doi: 10.1152/japplphysiol.00055.2018. Epub 2018 Mar 15. Erratum in: J Appl Physiol (1985). 2018 Aug 1;125(2):685. PMID: 29543135.

Gorecki P, Burke DL, Chapple ILC, Hemming K, Saund D, Pearson D, Stahl W, Lello R, Dietrich T. Perioperative supplementation with a fruit and vegetable juice powder concentrate and postsurgical morbidity: A double-blind, randomised, placebo-controlled clinical trial. Clin Nutr. 2018 Oct;37(5):1448-1455. doi: 10.1016/j.clnu.2017.08.004. Epub 2017 Aug 10. PMID: 28866140.

2017

Sack-Zschauer M, Karaman-Aplak E, Wyrich C, Das S, Schubert T, Meyer H, Janiak C, Seal S, Stahl W, Brenneisen P. Efficacy of Different Compositions of Cerium Oxide Nanoparticles in Tumor-Stroma Interaction. J Biomed Nanotechnol. 2017 Dec 1;13(12):1735-1746. doi: 10.1166/jbn.2017.2452. PMID: 29490761.

Decroix L, Tonoli C, Soares DD, Descat A, Drittij-Reijnders MJ, Weseler AR, Bast A, Stahl W, Heyman E, Meeusen R. Acute cocoa Flavanols intake has minimal effects on exercise-induced oxidative stress and nitric oxide production in healthy cyclists: a randomized controlled trial. J Int Soc Sports Nutr. 2017 Aug 10;14:28. doi: 10.1186/s12970-017-0186-7. eCollection 2017. PMID: 28811749.

Bohn T, Desmarchelier C, Dragsted LO, Nielsen CS, Stahl W, Rühl R, Keijer J, Borel P. Host-related factors explaining interindividual variability of carotenoid bioavailability and tissue concentrations in humans. Mol Nutr Food Res. 2017 Jun;61(6). doi: 10.1002/mnfr.201600685. Epub 2017 Feb 27. Review. PMID: 28101967.

Grether-Beck S, Marini A, Jaenicke T, Stahl W, Krutmann J. Molecular evidence that oral supplementation with lycopene or lutein protects human skin against ultraviolet radiation: results from a double-blinded, placebo-controlled, crossover study. Br J Dermatol. 2017; 176:1120-1121. doi: 10.1111/bjd.15080. PMID: 27662341

 

2016

Stahl W. Carrots, tomatoes and cocoa: Research on dietary antioxidants in Düsseldorf. Arch BiochemBiophys. 2016 Apr 1;595:125-31. doi: 10.1016/j.abb.2015.06.023. Review. PMID: 27095228.

De Spirt S, Eckers A, Wehrend C, Micoogullari M, Sies H, Stahl W, Steinbrenner H. Interplay between the chalcone cardamonin and selenium in the biosynthesis of Nrf2-regulated antioxidant enzymes in intestinal Caco-2 cells. Free Radic Biol Med. 2016 Feb;91:164-71. doi: 10.1016/j.freeradbiomed.2015.12.011. Epub 2015 Dec 15. PMID: 26698667.

2015

Sommerburg O, De Spirt S, Mattern A, Joachim C, Langhans CD, Nesaretnam K, Siems W, Stahl W, Mall MA. Supplementation with red palm oil increases β-carotene and vitamin A blood levels in patients with cystic fibrosis. Mediators Inflamm. 2015;2015:817127. doi: 10.1155/2015/817127. Epub 2015 Jan 26. PMID: 25688177.

2014

Dias IH, Polidori MC, Li L, Weber D, Stahl W, Nelles G, Grune T, Griffiths HR. Plasma levels of HDL and carotenoids are lower in dementia patients with vascular comorbidities. J Alzheimers Dis. 2014;40(2):399-408. doi: 10.3233/JAD-131964. PMID: 24448787.

2013

Maydt D, De Spirt S, Muschelknautz C, Stahl W, Müller TJ. Chemical reactivity and biological activity of chalcones and other α,β-unsaturated carbonyl compounds. Xenobiotica. 2013 Aug;43(8):711-8. doi: 10.3109/00498254.2012.754112. Epub 2013 Jan 23. PMID: 23339572.

2012

Stahl W, Sies H. β-Carotene and other carotenoids in protection from sunlight. Am J Clin Nutr. 2012 Nov;96(5):1179S-84S. doi: 10.3945/ajcn.112.034819. Epub 2012 Oct 10. Review. PMID: 23053552.

Hundsdörfer C, Stahl W, Müller TJ, De Spirt S. UVA photoprotective properties of an artificial carotenylflavonoid hybrid molecule. Chem Res Toxicol. 2012 Aug 20;25(8):1692-8. doi: 10.1021/tx300158r. Epub 2012 Aug 2. PMID: 22799612.

Wagener S, Völker T, De Spirt S, Ernst H, Stahl W. 3,3'-Dihydroxyisorenieratene and isorenieratene prevent UV-induced DNA damage in human skin fibroblasts. Free Radic Biol Med. 2012 Aug 1;53(3):457-63. doi: 10.1016/j.freeradbiomed.2012.05.022. Epub 2012 May 23. PMID: 22634149.

Sies H, Hollman PC, Grune T, Stahl W, Biesalski HK, Williamson G. Protection by flavanol-rich foods against vascular dysfunction and oxidative damage: 27th Hohenheim Consensus Conference. Adv Nutr. 2012 Mar 1;3(2):217-21. doi: 10.3945/an.111.001578. PMID: 22516731.

Stahl W. Carotenoids in nutrition and health-developments and future trends. Mol Nutr Food Res. 2012 Feb;56(2):203. doi: 10.1002/mnfr.201270001. PMID: 22419531.

Polidori MC, De Spirt S, Stahl W, Pientka L. Conflict of evidence: carotenoids and other micronutrients in the prevention and treatment of cognitive impairment. Biofactors. 2012 Mar-Apr;38(2):167-71. doi: 10.1002/biof.1001. Epub 2012 Mar 15. Review. PMID: 22419511.

Stahl W, Sies H. Photoprotection by dietary carotenoids: concept, mechanisms, evidence and future development. Mol Nutr Food Res. 2012 Feb;56(2):287-95. doi: 10.1002/mnfr.201100232. Epub 2011 Sep 23. Review. PMID: 21953695.

2011

Heinrich U, Moore CE, De Spirt S, Tronnier H, Stahl W. Green tea polyphenols provide photoprotection, increase microcirculation, and modulate skin properties of women. J Nutr. 2011 Jun;141(6):1202-8. doi: 10.3945/jn.110.136465. Epub 2011 Apr 27. PMID: 21525260.

Brossette T, Hundsdörfer C, Kröncke KD, Sies H, Stahl W. Direct evidence that (-)-epicatechin increases nitric oxide levels in human endothelial cells. Eur J Nutr. 2011 Oct;50(7):595-9. doi: 10.1007/s00394-011-0172-9. Epub 2011 Feb 16. PMID: 21327831.

Alili L, Sack M, Karakoti AS, Teuber S, Puschmann K, Hirst SM, Reilly CM, Zanger K, Stahl W, Das S, Seal S, Brenneisen P. Combined cytotoxic and anti-invasive properties of redox-active nanoparticles in tumor-stroma interactions. Biomaterials. 2011 Apr;32(11):2918-29. doi: 10.1016/j.biomaterials.2010.12.056. Epub 2011 Jan 26. PMID: 21269688.

2010

Grune T, Lietz G, Palou A, Ross AC, Stahl W, Tang G, Thurnham D, Yin SA, Biesalski HK. Beta-carotene is an important vitamin A source for humans. J Nutr. 2010 Dec;140(12):2268S-2285S. doi: 10.3945/jn.109.119024. Epub 2010 Oct 27. PMID: 20980645.

Klaus V, Hartmann T, Gambini J, Graf P, Stahl W, Hartwig A, Klotz LO. 1,4-Naphthoquinones as inducers of oxidative damage and stress signaling in HaCaT human keratinocytes. Arch Biochem Biophys. 2010 Apr 15;496(2):93-100. doi: 10.1016/j.abb.2010.02.002. Epub 2010 Feb 12. PMID: 20153715.

Lutter K, De Spirt S, Kock S, Kröncke KD, Martin HD, Wagener T, Stahl W. 3,3'-Dihydroxyisorenieratene prevents UV-induced formation of reactive oxygen species and the release of protein-bound zinc ions in human skin fibroblasts. Mol Nutr Food Res. 2010 Feb;54(2):285-91. doi: 10.1002/mnfr.200900044. PMID: 19862772.

2009

Polidori MC, Praticó D, Mangialasche F, Mariani E, Aust O, Anlasik T, Mang N, Pientka L, Stahl W, Sies H, Mecocci P, Nelles G. High fruit and vegetable intake is positively correlated with antioxidant status and cognitive performance in healthy subjects. J Alzheimers Dis. 2009;17(4):921-7. doi: 10.3233/JAD-2009-1114. PMID: 19542607.

Marian CM, Kock SC, Hundsdörfer C, Martin HD, Stahl W, Ostroumov E, Müller MG, Holzwarth AR. Spectroscopic properties of phenolic and quinoid carotenoids: a combined theoretical and experimental study. Photochem Photobiol Sci. 2009 Feb;8(2):270-8. doi: 10.1039/b814713b. Epub 2008 Dec 15. PMID: 19247521.

Polidori MC, Carrillo JC, Verde PE, Sies H, Siegrist J, Stahl W. Plasma micronutrient status is improved after a 3-month dietary intervention with 5 daily portions of fruits and vegetables: implications for optimal antioxidant levels. Nutr J. 2009 Feb 10;8:10. doi: 10.1186/1475-2891-8-10. PMID: 19208246.

Martin HD, Kock S, Scherrers R, Lutter K, Wagener T, Hundsdörfer C, Frixel S, Schaper K, Ernst H, Schrader W, Görner H, Stahl W. 3,3'-Dihydroxyisorenieratene, a natural carotenoid with superior antioxidant and photoprotective properties. Angew Chem Int Ed Engl. 2009;48(2):400-3. doi: 10.1002/anie.200803668. PMID: 19034947.

Camera E, Mastrofrancesco A, Fabbri C, Daubrawa F, Picardo M, Sies H, Stahl W. Astaxanthin, canthaxanthin and beta-carotene differently affect UVA-induced oxidative damage and expression of oxidative stress-responsive enzymes. Exp Dermatol. 2009 Mar;18(3):222-31. doi: 10.1111/j.1600-0625.2008.00790.x. Epub 2008 Sep 18. PMID: 18803658.

De Spirt S, Stahl W, Tronnier H, Sies H, Bejot M, Maurette JM, Heinrich U. Intervention with flaxseed and borage oil supplements modulates skin condition in women. Br J Nutr. 2009 Feb;101(3):440-5. doi: 10.1017/S0007114508020321. Epub 2008 Sep 2. PMID: 18761778.

2007

Stahl W, Sies H. Carotenoids and flavonoids contribute to nutritional protection against skin damage from sunlight. Mol Biotechnol. 2007 Sep;37(1):26-30. Review. PMID: 17914160.

Polidori MC, Praticó D, Parente B, Mariani E, Cecchetti R, Yao Y, Sies H, Cao P, Mecocci P, Stahl W. Elevated lipid peroxidation biomarkers and low antioxidant status in atherosclerotic patients with increased carotid or iliofemoral intima media thickness. J Investig Med. 2007 May;55(4):163-7. doi: 10.2310/6650.2007.06043. PMID: 17651669.

Galli F, Polidori MC, Stahl W, Mecocci P, Kelly FJ. Vitamin E biotransformation in humans. Vitam Horm. 2007;76:263-80. Review. PMID: 17628177.

Peterson LA, Wagener T, Sies H, Stahl W. Decomposition of S-nitrosocysteine via S- to N-transnitrosation. Chem Res Toxicol. 2007 May;20(5):721-3. Epub 2007 Apr 18. PMID: 17439249.

Neukam K, Stahl W, Tronnier H, Sies H, Heinrich U. Consumption of flavanol-rich cocoa acutely increases microcirculation in human skin. Eur J Nutr. 2007 Feb;46(1):53-6. Epub 2006 Dec 11. PMID: 17164979.

2006

Heinrich U, Neukam K, Tronnier H, Sies H, Stahl W. Long-term ingestion of high flavanol cocoa provides photoprotection against UV-induced erythema and improves skin condition in women. J Nutr. 2006 Jun;136(6):1565-9. PMID: 16702322.

Stahl W, Heinrich U, Aust O, Tronnier H, Sies H. Lycopene-rich products and dietary photoprotection. Photochem Photobiol Sci. 2006 Feb;5(2):238-42. Epub 2005 Aug 12. Review. PMID: 16465309.

2005

Polidori MC, Praticó D, Ingegni T, Mariani E, Spazzafumo L, Del Sindaco P, Cecchetti R, Yao Y, Ricci S, Cherubini A, Stahl W, Sies H, Senin U, Mecocci P; AVASAS Study Group. Effects of vitamin C and aspirin in ischemic stroke-related lipid peroxidation: results of the AVASAS (Aspirin Versus Ascorbic acid plus Aspirin in Stroke) Study. Biofactors. 2005;24(1-4):265-74. PMID: 16403987.

Anlasik T, Sies H, Griffiths HR, Mecocci P, Stahl W, Polidori MC. Dietary habits are major determinants of the plasma antioxidant status in healthy elderly subjects. Br J Nutr. 2005 Nov;94(5):639-42. PMID: 16277763.

Daubrawa F, Sies H, Stahl W. Astaxanthin diminishes gap junctional intercellular communication in primary human fibroblasts. J Nutr. 2005 Nov;135(11):2507-11. PMID: 16251602.

Maggio D, Polidori MC, Barabani M, Tufi A, Ruggiero C, Cecchetti R, Aisa MC, Stahl W, Cherubini A. Low levels of carotenoids and retinol in involutional osteoporosis. Bone. 2006 Feb;38(2):244-8. Epub 2005 Sep 26.  PMID: 16188508.

2005

Stahl W, Sies H. Bioactivity and protective effects of natural carotenoids. Biochim Biophys Acta. 2005 May 30;1740(2):101-7. Epub 2004 Dec 28. Review. PMID: 15949675.

Sies H, Stahl W, Sevanian A. Nutritional, dietary and postprandial oxidative stress. J Nutr. 2005 May;135(5):969-72. Review. PMID: 15867266.

Aust O, Stahl W, Sies H, Tronnier H, Heinrich U. Supplementation with tomato-based products increases lycopene, phytofluene, and phytoene levels in human serum and protects against UV-light-induced erythema. Int J Vitam Nutr Res. 2005 Jan;75(1):54-60. PMID: 15830922.

2004

Polidori MC, Praticó D, Savino K, Rokach J, Stahl W, Mecocci P. Increased F2 isoprostane plasma levels in patients with congestive heart failure are correlated with antioxidant status and disease severity. J Card Fail. 2004 Aug;10(4):334-8. PMID: 15309701.

Sies H, Stahl W. Carotenoids and UV protection. Photochem Photobiol Sci. 2004 Aug;3(8):749-52. Epub 2004 Apr 1. Review. PMID: 15295630.

Polidori MC, Mattioli P, Aldred S, Cecchetti R, Stahl W, Griffiths H, Senin U, Sies H, Mecocci P. Plasma antioxidant status, immunoglobulin g oxidation and lipid peroxidation in demented patients: relevance to Alzheimer disease and vascular dementia. Dement Geriatr Cogn Disord. 2004;18(3-4):265-70. Epub 2004 Jul 29. PMID: 15286458.

Sies H, Stahl W. Nutritional protection against skin damage from sunlight. Annu Rev Nutr. 2004;24:173-200. Review. PMID: 15189118.

2003

Stahl W, Sies H. Antioxidant activity of carotenoids. Mol Aspects Med. 2003 Dec;24(6):345-51. Review.  PMID: 14585305.

Betancor-Fernández A, Pérez-Gálvez A, Sies H, Stahl W. Screening pharmaceutical preparations containing extracts of turmeric rhizome, artichoke leaf, devil's claw root and garlic or salmon oil for antioxidant capacity.  J Pharm Pharmacol. 2003 Jul;55(7):981-6. PMID: 12906755.

Polidori MC, Mecocci P, Stahl W, Sies H. Cigarette smoking cessation increases plasma levels of several antioxidant micronutrients and improves resistance towards oxidative challenge. Br J Nutr. 2003 Jul;90(1):147-50. PMID: 12844386.

Pérez-Gálvez A, Martin HD, Sies H, Stahl W. Incorporation of carotenoids from paprika oleoresin into human chylomicrons. Br J Nutr. 2003 Jun;89(6):787-93. PMID: 12828795.

Sies H, Stahl W. Non-nutritive bioactive constituents of plants: lycopene, lutein and zeaxanthin. Int J Vitam Nutr Res. 2003 Mar;73(2):95-100. Review. PMID: 12747216.

Mensink RP, Aro A, Den Hond E, German JB, Griffin BA, ten Meer HU, Mutanen M, Pannemans D, Stahl W. PASSCLAIM - Diet-related cardiovascular disease. Eur J Nutr. 2003 Mar;42 Suppl 1:I6-27. Review. PMID: 12664321.

Heinrich U, Gärtner C, Wiebusch M, Eichler O, Sies H, Tronnier H, Stahl W. Supplementation with beta-carotene or a similar amount of mixed carotenoids protects humans from UV-induced erythema. J Nutr. 2003 Jan;133(1):98-101. PMID: 12514275.

2002

Betancor-Fernandez A, Sies H, Stahl W, Polidori MC. In vitro antioxidant activity of 2,5,7,8-tetramethyl-2-(2'-carboxyethyl)-6-hydroxychroman (alpha-CEHC), a vitamin E metabolite. Free Radic Res. 2002 Aug;36(8):915-21. PMID: 12420750.

Stahl W, Sies H. Carotenoids and protection against solar UV radiation. Skin Pharmacol Appl Skin Physiol. 2002 Sep-Oct;15(5):291-6. Review. PMID:12239422.

Radosavac D, Graf P, Polidori MC, Sies H, Stahl W. Tocopherol metabolites 2, 5, 7, 8-tetramethyl-2-(2'-carboxyethyl)-6-hydroxychroman (alpha-CEHC) and 2, 7, 8-trimethyl-2-(2'-carboxyethyl)-6-hydroxychroman (gamma-CEHC) in human serum after a single dose of natural vitamin E. Eur J Nutr. 2002 Jun;41(3):119-24.  PMID: 12111049.

Ale-Agha N, Stahl W, Sies H. (-)-Epicatechin effects in rat liver epithelial cells: stimulation of gap junctional communication and counteraction of its loss due to the tumor promoter 12-O-tetradecanoylphorbol-13-acetate. Biochem Pharmacol. 2002 Jun 15;63(12):2145-9. PMID: 12110373.

Jackson MJ, Papa S, Bolaños J, Bruckdorfer R, Carlsen H, Elliott RM, Flier J, Griffiths HR, Heales S, Holst B, Lorusso M, Lund E, Øivind Moskaug J, Moser U, Di Paola M, Polidori MC, Signorile A, Stahl W, Viña-Ribes J, Astley SB. Antioxidants, reactive oxygen and nitrogen species, gene induction and mitochondrial function. Mol Aspects Med. 2002 Feb-Jun;23(1-3):209-85. Review. PMID: 12079772.

Stahl W, van den Berg H, Arthur J, Bast A, Dainty J, Faulks RM, Gärtner C, Haenen G, Hollman P, Holst B, Kelly FJ, Polidori MC, Rice-Evans C, Southon S, van Vliet T, Viña-Ribes J, Williamson G, Astley SB. Bioavailability and metabolism. Mol Aspects Med. 2002 Feb-Jun;23(1-3):39-100. Review. PMID: 12079770.

Polidori MC, Cherubini A, Stahl W, Senin U, Sies H, Mecocci P. Plasma carotenoid and malondialdehyde levels in ischemic stroke patients: relationship to early outcome. Free Radic Res. 2002 Mar;36(3):265-8. PMID: 12071344.

Stahl W, Ale-Agha N, Polidori MC. Non-antioxidant properties of carotenoids. Biol Chem. 2002 Mar-Apr;383(3-4):553-8. Review. PMID: 12033443.

Eichler O, Sies H, Stahl W. Divergent optimum levels of lycopene, beta-carotene and lutein protecting against UVB irradiation in human fibroblastst. Photochem Photobiol. 2002 May;75(5):503-6. PMID: 12017476.

Mecocci P, Polidori MC, Cherubini A, Ingegni T, Mattioli P, Catani M, Rinaldi P, Cecchetti R, Stahl W, Senin U, Beal MF. Lymphocyte oxidative DNA damage and plasma antioxidants in Alzheimer disease. Arch Neurol. 2002 May;59(5):794-8. PMID: 12020262.

Alaluf S, Heinrich U, Stahl W, Tronnier H, Wiseman S. Dietary carotenoids contribute to normal human skin color and UV photosensitivity. J Nutr. 2002 Mar;132(3):399-403. PMID: 11880562.

Polidori MC, Savino K, Alunni G, Freddio M, Senin U, Sies H, Stahl W, Mecocci P. Plasma lipophilic antioxidants and malondialdehyde in congestive heart failure patients: relationship to disease severity. Free Radic Biol Med. 2002 Jan 15;32(2):148-52. PMID: 11796203.

 

 

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