Forschergruppe 729 - Research Unit 729

The research program of RU729 aims at the understanding of the activation and function of molecular effector mechanisms within the mammalian immune system.
Research thereby focuses on the elucidation of mechanisms of cells and subcellular compartments which control invading pathogens. On the other hand the molecular mechanism of virulence factors / strategies of selected pathogens that interfere with the activation and execution of immunological effector programs are at the center of the research program.

The Research Unit 729 is composed of 8 projects that synergistically and cooperatively tackle the central scientific questions how intracellular pathogens are inactivated and how specialized pathogens can interfere with host immunity ultimately identifying the immunological key molecules on the host side and the virulence key factors on the pathogens. Furthermore the biology of these key molecules shall be unraveled.

Project P1: CXCL14/BRAK: Organization of immune defense at barrier organs
Bernhard Homey, Department of Dermatology,
Heinrich-Heine-University of Düsseldorf

Project P2: Mechanisms of cell and isoformspecifity of Gi- protein dependent signal pathways in inflammatory cells
          - Project P2 is continued independently of RU 729 -
Bernd Nürnberg, Antje Gohla, Institute of Biochemistry and Molecular Biology II,
Heinrich-Heine-University of Düsseldorf

Project P3: The role of the Chlamydia pneumoniae protein Pmp21 during infection

Johannes Hegemann, Institute for Functional Genomics of Microorganisms,
Heinrich-Heine-University of Düsseldorf

Project P4: Antimicrobial effects mediated by the regulation of the local tryptophan concentration: diverse effects mediated by different tryptophan degrading enzymes in mice and man
Walter Däubener, Institute of Medical Microbiology and Hospital Hygiene,
Heinrich-Heine-University of Düsseldorf

Project P5: Metabolic regulation of inflammatory processes: HIF-1? and IDO as anti-infectious effector molecules in professional phagocytes
Irmgard Förster, Institute of Environmental Health Research (IUF) Düsseldorf

Project P6: The biological role of interferon-? induced 65 kDa GBPs as effector molecules in host defense
Klaus Pfeffer, Institute of Medical Microbiology and Hospital Hygiene,
Heinrich-Heine-University of Düsseldorf

Project P7: Interference of HCV with inflammatory effector systems
Johannes Bode, Dieter Häussinger, Department of Gastroenterology, Hepatology and Infectiology
Heinrich-Heine-University of Düsseldorf

Project P8: Control of CD8+ T cells through interference of cytomegalovirus with the peptide loading complex (PLC)
Anne Halenius, Hartmut Hengel, Institute of Virology, 
Heinrich-Heine-University of Düsseldorf

Project P9: Visualization of IL-22 expressing cells during anti-infectious immune responses
Stefanie Scheu, Institute of Medical Microbiology and Hospital Hygiene,
Heinrich-Heine-University of Düsseldorf


FOR 729, Förderperiode 2007-2008-2009 (Archiv)



Gemeinsame Seminarreihe der Institute für Biochemie und Molekularbiologie II, für Medizinische Mikrobiologie und Krankenhaushygiene und für Virologie 

in Kooperation mit

dem BMFZ und den SFBs 575, 590, 612 & 974.

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