Publications

Jain C, Dilthey A, Koren S, Aluru S and Phillippy AM. A Fast Approximate Algorithm for Mapping Long Reads to Large Reference Databases. in Research in Computational Molecular Biology: 21st Annual International Conference, RECOMB 2017, Hong Kong, China, May 3-7, Proceedings (ed. Sahinalp, S.C.) 66-81 (Springer International Publishing, Cham, 2017).

Cortes A, Dendrou CA, Motyer A, Jostins L, Vukcevic D, Dilthey A, Donnelly P, Leslie S, Fugger L and McVean G. Bayesian analysis of genetic association across tree-structured routine healthcare data in the UK Biobank. Nat Genet 49, 1311-1318 (2017).

Dilthey AT, Gourraud PA, Mentzer AJ, Cereb N, Iqbal Z and McVean G. High Accuracy HLA Type Inference from Whole-Genome Sequencing Data Using Population Reference Graphs.  PLoS Comput Biol 12, e1005151 (2016).

Vukcevic D, Traherne JA, Naess S, Ellinghaus E, Dilthey A, Lathrop M, Karlsen TH, Franke A, Moffatt M, Cookson W, Trowsdale J, McVean G, Sawcer S and Leslie S. Imputation of KIR Types from SNP Variation Data. Am J Hum Genet 97, 593-607 (2015).

Parham LR, Briley LP, Li L, Shen J, Newcombe PJ, King KS, Slater AJ, Dilthey A, Iqbal Z, McVean G, Cox CJ, Nelson MR and Spraggs CF. Comprehensive genome-wide evaluation of lapatinib-induced liver injury yields a single genetic signal centered on known risk allele HLA-DRB1*07:01. Pharmacogenomics J (2015). 

International Multiple Sclerosis Genetics Consortium, Moutsianas L, Jostins L, Beecham AH, Dilthey A, Xifara DK, Ban M, Shah TS, Patsopoulos NA, Alfredsson L, Anderson CA, Attfield KE, Baranzini SE, Barrett J, Binder T, Booth D, Buck D, Celius EG, Cotsapas C, D'alfonso S, Dendrou CA, Donnelly P, Dubois B, Fontaine B, Fugger L, Goris A, Gourraud PA, Graetz C, Hemmer B, Hillert J, International IBD Genetics Consortium (IIBDGC), Kockum I, Leslie S, Lill CM, Martinelli-Boneschi F, Oksenberg JR, Olsson T, Oturai A, Saarela J, Søndergaard HB, Spurkland A, Taylor B, Winkelmann J, Zipp F, Haines JL, Pericak-Vance MA, Spencer CCA, Stewart G, Hafler DA, Ivinson AJ, Harbo HF, Hauser SL, De Jager PL, Compston A, McCauley JL, Sawcer S and McVean G. Class II HLA interactions modulate genetic risk for multiple sclerosis. Nat Genet (2015).

Dilthey A and Lercher MJ. Horizontally transferred genes cluster spatially and metabolically. Biol Direct 10, 72 (2015).

Dilthey A, Cox C, Iqbal Z, Nelson MR and McVean G. Improved genome inference in the MHC using a population reference graph. Nat Genet 47, 682-688 (2015).

Dilthey A, Leslie S, Moutsianas L, Shen J, Cox C, Nelson MR and McVean G. Multi-population classical HLA type imputation. PLoS Comput Biol 9, e1002877 (2013).

International Multiple Sclerosis Genetics Consortium et alAnalysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. Nat Genet 45, 1353-1360 (2013).

Fairfax BP, Makino S, Radhakrishnan J, Plant K, Leslie S, Dilthey A, Ellis P, Langford C, Vannberg FO and Knight JC. Genetics of gene expression in primary immune cells identifies cell type-specific master regulators and roles of HLA alleles. Nat Genet 44, 502-510 (2012).

Chen H, Hayashi G, Lai OY, Dilthey A, Kuebler PJ, Wong TV, Martin MP, Fernandez Vina MA, McVean G, Wabl M, Leslie KS, Maurer T, Martin JN, Deeks SG, Carrington M, Bowcock AM, Nixon DF and Liao W. Psoriasis patients are enriched for genetic variants that protect against HIV-1 disease. PLoS Genet 8, e1002514 (2012).

Moutsianas L, Encis-Mora V, Ma YP, Leslie S, Dilthey A, Broderick P, Sherborne A, Cooke R, Ashworth A, Swerdlow AJ, McVean G and Houlston RS. Multiple Hodgkin lymphoma-associated loci within the HLA region at chromosome 6p21.3. Blood 118, 670-674 (2011).

International Multiple Sclerosis Genetics Consortium et alGenetic risk and primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature 476, 214-219 (2011).

Hosking FJ, Leslie S, Dilthey A, Moutsianas L, Wang Y, Dobbins SE, Papaemmanuil E, Sheridan E, Kinsey SE, Lightfoot T, Roman E, Irving JA, Allan JM, Taylor M, Greaves M, McVean G and Houlston RS. MHC variation and risk of childhood B-cell precursor acute lymphoblastic leukemia. Blood 117, 1633-1640 (2011).

Evans DM, Spencer CC, Pointon JJ, Su Z, Harvey D, Kochan G, Oppermann U, Dilthey A, Pirinen M, Stone MA, Appleton L, Moutsianas L, Leslie S, Wordsworth T, Kenna TJ, Karaderi T, Thomas GP, Ward MM, Weisman MH, Farrar C, Bradbury LA, Danoy P, Inman RD, Maksymowych W, Gladman D, Rahman P, Spondyloarthritis Research Consortium of Canada, Morgan A, Marzo-Ortega H, Bowness P, Gaffney K, Gaston JS, Smith M, Bruges-Armas J, Couto AR, Sorrentino R, Paladini F, Ferreira MA, Xu H, Liu Y, Jiang L, Lopez-Larrea C, Diaz-Pena R, Lopez-Vazquez A, Zayats T, Band G, Bellenguez C, Blackburn H, Blackwell JM, Bramon E, Bumpstead SJ, Casas JP, Corvin A, Craddock N, Deloukas P, Dronov S, Duncanson A, Edkins S, Freeman C, Gillman M, Gray E, Gwilliam R, Hammond N, Hunt SE, Jankowski J, Jayakumar A, Langford C, Liddle J, Markus HS, Mathew CG, McCann OT, McCarthy MI, Palmer CN, Peltonen L, Plomin R, Potter SC, Rautanen A, Ravindrarajah R, Ricketts M, Samani N, Sawcer SJ, Strange A, Trembath RC, Viswanathan AC, Waller M, Weston P, Whittaker P, Widaa S, Wood NW, McVean G, Reveille JD, Wordsworth BP, Brown MA, Donnelly P, Australo-Anglo-American Spondyloarthritis Consortium and Wellcome Trust Case Control Consortium. Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility. Nat Genet 43, 761-767 (2011).

Dilthey AT, Moutsianas L, Leslie S and McVean. HLA*IMP--an integrated framework for imputing classical HLA alleles from SNP genotypes. Bioinformatics 27, 968-972 (2011).

Genetic Analysis of Psoriasis Consortium and the Wellcome Trust Case Control Consortium, Strange A, Capon F, Spencer CC, Knight J, Weale ME, Allen MH, Barton A, Band G, Bellenguez C, Bergboer JG, Blackwell JM, Bramon E, Bumpstead SJ, Casas JP, Cork MJ, Corvin A, Deloukas P, Dilthey A, Duncanson A, Edkins S, Estivill X, Fitzgerald O, Freeman C, Giardina E, Gray E, Hofer A, Huffmeier U, Hunt SE, Irvine AD, Jankowski J, Kirby B, Langford C, Lascorz J, Leman J, Leslie S, Mallbris L, Markus HS, Mathew CG, McLean WH, McManus R, Mossner R, Moutsianas L, Naluai AT, Nestle FO, Novelli G, Onoufriadis A, Palmer CN, Perricone C, Pirinen M, Plomin R, Potter SC, Pujol RM, Rautanen A, Riveira-Munoz E, Ryan AW, Salmhofer W, Samuelsson L, Sawcer SJ, Schalkwijk J, Smith CH, Stahle M, Su Z, Tazi-Ahnini R, Traupe H, Viswanathan AC, Warren RB, Weger W, Wolk K, Wood N, Worthington J, Young HS, Zeeuwen PL, Hayday A, Burden AD, Griffiths CE, Kere J, Reis A, McVean G, Evans DM, Brown MA, Barker JN, Peltonen L, Donnelly P and Trembath RC. A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1. Nat Genet 42, 985-990 (2010).

MediathekInformation und Wissen
LageplanSo finden Sie uns