Publications

Ellinger P, Arslan Z, Wurm R, Tschapek B, MacKenzie C, Pfeffer K, Panjikar S, Wagner R, Schmitt L, Gohlke H, Pul Ü, Smits SH. The crystal structure of the CRISPR-associated protein Csn2 from Streptococcus agalactiae.J Struct Biol. 2012 Jun;178(3):350-62.


Albrecht P, Henke N, Lehmann HC, Macht S, Hefter H, Goebels N, Mackenzie C, Rupprecht TA, Fingerle V, Hartung HP, Methner A. A case of relapsing-remitting neuroborreliosis? Challenges in the differential diagnosis of recurrent myelitis.Case Rep Neurol. 2012 Jan;4(1):47-53.


Meng W, Paunel-Gorgulu A, Flohe S, Hoffmann A, Witte I, Mackenzie C, Baldus S, Windolf J, Logters TT. Depletion of neutrophil extracellular traps in vivo results in hypersusceptibility to polymicrobial sepsis in mice. Crit Care. 2012 Jul 26;16(4):R137.

Babor F, Schuster F, Mackenzie C, Meisel R, Schaper J, Sabir H, Siepermann M, Wessalowski R, Janßen G, Borkhardt A, Laws HJ. Invasive aspergillosis in pediatric oncology patients: a rare event with poor prognosis--case analysis to plan better targeted prophylactic or therapeutic measurement.Klin Padiatr. 2012 Apr;224(3):160-5.


Steindor M, Weizenegger M, Harrison N, Hirschl AM, Schweickert B, Göbel UB, Mackenzie CR.Use of a commercial PCR-based line blot method for identification of bacterial pathogens and the mecA and van genes from BacTAlert blood culture bottles. J Clin Microbiol. 2012 Jan;50(1):157-9.

D.D. Singh, M. Vogel, I. Müller-Stöver, T. el Scheich, M. Winzer, S. Göbels, F. Hüttig, S. Heinrich, C. MacKenzie, B. Jensen, S. Reuter, D. Häussinger, J. Richter TB or not TB? Difficulties in the diagnosis of Tuberculosis in HIV-negative Immigrants to GermanyEuropean Journal of Medical Research 2011; 16 (9); 381-385


Pohle S, Ernst R, MacKenzie C, Spicher M, Romig T, Hemphill A, Gripp S. Echinococcus multilocularis: the impact of ionizing radiation on metacestodes.Exp Parasitol. 2011 Jan;127(1):127-34.

MacKenzie CR, Nischik N, Kram R, Krauspe R, Jäger M, Henrich B. Fatal outcome of a disseminated dual infection with drug-resistant Mycoplasma hominis and Ureaplasma parvum originating from a septic arthritis in an immunocompromised patient.Int J Infect Dis. 2010 Sep;14 Suppl 3:e307-9.


Hardegen C, Messler S, Henrich B, Pfeffer K, Würthner J, MacKenzie CR. A set of novel multiplex Taqman real-time PCRs for the detection of diarrhoeagenic Escherichia coli and its use in determining the prevalence of EPEC and EAEC in a university hospital.Ann Clin Microbiol Antimicrob. 2010 Jan 22;9:5.


Däubener W, Schmidt SK, Heseler K, Spekker KH, MacKenzie CR. Antimicrobial and immunoregulatory effector mechanisms in human endothelial cells. Indoleamine 2,3-dioxygenase versus inducible nitric oxide synthase.Thromb Haemost. 2009 Dec;102(6):1110-6.


Weinspach S, Tenenbaum T, Schönberger S, Schaper J, Engers R, Rueggeberg J, Mackenzie CR, Wolf A, Mayatepek E, Schroten H. Cat Scratch Disease - Heterogeneous in Clinical Presentation: Five Unusual Cases of an Infection Caused by Bartonella henselae.Klin Padiatr. 2009 Sep 29.


Schmidt SK, Müller A, Heseler K, Woite C, Spekker K, MacKenzie CR, Däubener W. Antimicrobial and immunoregulatory properties of human tryptophan 2,3-dioxygenase.Eur J Immunol. 2009 Oct;39(10):2755-64.

Müller A, Heseler K, Schmidt SK, Spekker K, Mackenzie CR, Däubener W. The missing link between indoleamine 2,3-dioxygenase mediated antibacterial and immunoregulatory effects.J Cell Mol Med. 2009 Jun;13(6):1125-35.

Weber C, Schaper J, Tibussek D, Adams O, Mackenzie CR, Dilloo D, Meisel R, Göbel U, Laws HJ. Diagnostic and therapeutic implications of neurological complications following paediatric haematopoietic stem cell transplantation.Bone Marrow Transplant. 2008 Feb;41(3):253-9.


Heseler K, Spekker K, Schmidt SK, Mackenzie CR, Däubener W. Antimicrobial and immunoregulatory effects mediated by human lung cells: role of IFN-gamma-induced tryptophan degradation.FEMS Immunol Med Microbiol. 2008 Feb 12;52(2):273-281.


Calaminus G, Hense B, Laws HJ, Groeger M, MacKenzie CR, Göbel U. Diphtheria (D) and tetanus (T) antibody values in children with acute lymphoblastic leukaemia (ALL) after treatment according to Co-ALL 05/92.Klin Padiatr. 2007 Nov-Dec;219(6):355-60.


Virtej A, MacKenzie CR, Raab WH, Pfeffer K, Barthel CR. Determination of the performance of various root canal disinfection methods after in situ carriage. J Endod. 2007 Aug;33(8):926-9


H. J. Laws, D. T. Schneider, G. Janssen, R. Wessalowski, D Dilloo, and R. Meisel, O. Adams, C. Mackenzie and U. Göbel Trends in Infections in Children with Malignant Disease in 2000: Comparison of Data of 1980/8.Pediatric Hematology and Oncology, 24:343–354, 2007

C R Mackenzie, K Heseler, A Muller, and Walter Daubener Role of Indoleamine 2,3-Dioxygenase in Antimicrobial Defence and Immuno-Regulation: Tryptophan Depletion Versus Production of Toxic Kynurenines. Curr Drug Metab. 2007; 8: 237.


Tenenbaum T, Hoehn T, Hadzik B, Stannigel H, Mackenzie CR, Mayatepek E, Schroten H. Exchange transfusion in a preterm infant with hyperbilirubinemia, staphylococcal scalded skin syndrome (SSSS) and sepsis. Eur J Pediatr. 2006 Nov 16;


Tenenbaum, T., Heusch, A., Henrich, B., MacKenzie, C.R., Schmidt, K.G., Schroten, H. Acute hemorrhagic pericarditis in a child with pneumonia due to Chlamydophila pneumoniae.Journal of Clinical Microbiology 2005 43 (1), pp. 520-522


Adams, O., Besken, K., Oberdörfer, C., MacKenzie, C.R., Rüßing, D., Däubener, W. Inhibition of human herpes simplex virus type 2 by interferon ? and tumor necrosis factor ? is mediated by indoleamine 2,3-dioxygenase.Microbes and Infection 2004 6 (9), pp. 806-812


Koku D. Z. Adjogble, Corinne Mercier, Jean-Francois Dubremetz, Christian Hucke, Colin R. MacKenzie, Marie-France Cesbron-Delauw, Walter Däubener GRA9, a new Toxoplasma gondii dense granule protein associated with the intravacuolar network of tubular membranes.Int J Parasitol 2004 34: 1255-1264


Giese A, Stuhlsatz S, Däubener W and MacKenzie C.R.Inhibition of the Growth of Toxoplasma gondii in Immature Human Dendritic Cells is Dependent on the Expression of TNF-alpha Receptor 2. J Immunol. 2004 Sep 1;173(5):3366-74


J.U. Rüggeberg, K. Ketteler, C. R. MacKenzie, R. von Kries, R. R. Reinert, H. Schroten. Blood Culture Sampling Rates at a German Pediatric University Hospital and Incidence of Invasive Pneumococcal Disease.Infection 2004, 32 (2): 78-81


Christian Hucke, Colin R. MacKenzie, Koku D. Z. Adjogble, Osamu Takikawa, and Walter Däubener  Nitric Oxide-Mediated Regulation of Gamma Interferon-Induced Bacteriostasis: Inhibition and Degradation of Human Indoleamine 2,3-Dioxygenase.Infect. Immun. 2004;72 2723-2730


O. Adams, K. Besken, C. Oberdörfer, C. R. MacKenzie, O. Takikawa, and W. Däubener. Role of Indoleamine-2,3-Dioxygenase in Alpha/Beta and Gamma Interferon-Mediated Antiviral Effects against Herpes Simplex Virus Infections.J Virol, 2004,. 78: 2632-2636


C.R. MacKenzie, D. Worku and W. Däubener. Regulation of IDO-mediated bacteriostasis in macrophages: Role of antibiotics and anti-inflammatory agents.Adv. Exp. Med. Biol. 2003 527: 67-76


C. Oberdorfer, O. Adams, C.R. MacKenzie, C.J.A. De Groot and W. Däubener Role of IDO activation in anti-microbial defense in human native astrocytes.Adv. Exp. Med. Biol. 2003 527: 15-26


Gobels K, Best J, Oette M, MacKenzie CR, Hemker J, Wenning M, Haussinger D. Ocular infection caused by Mycobacterium kansasii in an AIDS patient.AIDS. 2002 Dec 6;16(18):2501-2.


Turck J, Oberdorfer C, Vogel T, MacKenzie CR, Däubener W.  Enhancement of antimicrobial effects by glucocorticoids.Med Microbiol Immunol (Berl) 18 Nov 2003.


K. Göbels, J. Hemker, M. Oette, M. Wettstein, T. Heintges, D. Teichmann, C. R. MacKenzie, D. Häusinger Capreomycin in the treatment of atypical mycobacterial disease in HIV-positive patients.Eur J Clin Microbiol Infect Dis 2002, 21: 563-565


Sedlmayr P, Blaschitz A, Wintersteiger R, Semlitsch M, Hammer A, MacKenzie CR, Walcher W, Reich O, Takikawa O, Dohr, G. Localization of indoleamine 2,3-dioxygenase in human female reproductive organs and the placenta.Mol Hum Reprod 2002 Apr;8(4):385-391


Henrich B, Zähringer U, Guadarrama R, MacKenzie CR.The Detergent Octylglucoside Neutralizes Lipopolysaccharide in a Specific Manner.Med Microbiol Immun Berl. 2001 189: 133-13


G. Kögler, T Somville, U. Göbel, P. Hakenberg, A. Knipper, J. Fischer, O Adams, C. Krempe, C. MacKenzie, H. Rüttgers, W. Meier, O. Bellmann, H. Streng, A. Ring, U. Rossek, V. Rocha, P. Wernet. Haematopoietic transplant potential of unrelated and related cord blood: the first six years of the EURO-CORD/NETCORD bank Germany.Klein. Pädiatri. 1999 211: 224-232


Walter Däubener, Christian Hucke, Kerstin Seidel, Ulrich Hadding, and Colin R. MacKenzieInterleukin-1 Inhibits Gamma Interferon-Induced Bacteriostasis in Human Uroepithelial Cells.Infect Immun 1999 67: 5615-5620


Colin R. MacKenzie, Ralf Langen, Osamu Takikawa and Walter Däubener. Inhibition of indoleamine 2,3 dioxygenase in human macrophages inhibits interferon gamma-induced bacteriostasis but does not abrogate toxoplasmastasis.Eur J Immunol 1999 29:3254-3261


MacKenzie CR, Hucke C; Müller D; Seidel K; Däubener W. Growth Inhibition of multi resistant enterococci by interferon-gamma-activated human uroepithelial cells.J Med Microbiol, 1999 48:935-941


Walter Däubener and Colin R. MacKenzieIFN y activated indoleamine 2,3 dioxygenase activity in human cells is an anti parasitic and an antibacterial effector mechanism.Adv. Exp. Med. Biol. 1999 467: 524-532


MacKenzie CR, González RG, Kniep E, Roch S, Däubener, W. Cytokine Mediated Regulation of Interferon gamma Induced IDO Activation.Adv. Exp. Med. Biol. 1999 467: 533-540


Henrich B, Lang K, Kitzerow A, MacKenzie C, Hadding U. Truncation as a novel form of variation of the p50 gene in Mycoplasma hominis.Microbiol. 1998 144;2979-2985


Däubener W, Posdziech V, Hadding U, MacKenzie C. Inducible anti parasitic effector mechanisms in human uroepithelial cells: tryptophan degradation vs. NO production.Med Microbiol Immun Berl 1999 187: 143-147


MacKenzie CR; Willberg CB, Däubener W. Inhibition of group B streptococcal growth by IFN gamma activated human glioblastoma cells.J Neuroimmunol 1998 89: 191-7


MacKenzie CR; Hadding U; Däubener W. Interferon y Induced Activation of Indoleamine 2,3 Dioxygenase in Cord Blood Monocyte Derived Macrophages Inhibits the Growth of Group B Streptococci.J Infect Dis. 1998 178: 875-8


Schmitz FJ; Mackenzie CR; Hofmann B; Verhoef J; Finken Eigen M; Heinz HP; Kohrer K. Specific information concerning taxonomy, pathogenicity and methicillin resistance of staphylococci obtained by a multiplex PCR.J Med Microbiol. 1997 Sep; 46(9): 773-8


Schmitz FJ; MacKenzie CR; Geisel R; Wagner S; Idel H; Verhoef J; Hadding U; Heinz HP Enterotoxin and toxic shock syndrome toxin 1 production of methicillin resistant and methicillin sensitive Staphylococcus aureus strains.Eur J Epidemiol. 1997 Sep; 13(6): 699-708


Schmitz FJ; MacKenzie CR; Geisel R; Wagner S; Idel H; Verhoef J; Hadding U; Heinz HP Methicillin resistant Staphylococcus aureus strains in the greater Dusseldorf area.Eur J Epidemiol. 1997 Sep; 13(6): 709-17


K. Oberstadt, C. MacKenzie, C. Specker, T. Geist, T. Ruzicka, and H C. Schuppe. Tuberculosis cutis bei systemischem Lupus erythematodes und Schwangerschaft. HG. Zeitschrift für Hautkrankheiten. 1996; 71:4;296-29

MacKenzie C. R; Henrich B; Hadding U  Biovar specific epitopes of the urease enzyme of Ureaplasma urealyticum.J Med Microbiol. 1996 Nov; 45(5): 366-71


Daubener W; Gutsche M; Nockemann S; MacKenzie C; Seghrouchni S; Hadding U Protamine enhances the activity of human recombinant interferon gamma.J Interferon Cytokine Res. 1996 Jul; 16(7): 531-6


Daubener W; Remscheid C; Nockemann S; Pilz K; Seghrouchni S; Mackenzie C; Hadding U Antiparasitic effector mechanisms in human brain tumor cells: role of interferon gamma and tumor necrosis factor alpha.Eur J Immunol. 1996 Feb; 26(2): 487-92


Daubener W; Mackenzie C; Hadding U  Establishment of T helper type 1  and T helper type 2 like human Toxoplasma antigen specific T cell clones.Immunology. 1995 Sep; 86(1): 79-84


Ratcliffe LT; Lukey PT; MacKenzie CR; Ress SR  Reduced NK activity correlates with active disease in HIV  patients with multidrug resistant pulmonary tuberculosis.Clin Exp Immunol. 1994 Sep; 97(3): 373-9


Willcox, P.A., Groenewald, P.J., MacKenzie, C.R.Ofloxacin-based chemotherapy in multiply drug-resistant pulmonary tuberculosis. Drugs 46 (SUPPL. 3), pp. 223-22

Ratcliffe LT; Mackenzie CR; Lukey PT; Ress SR  Reduced natural killer cell activity in multi drug resistant pulmonary tuberculosis.Scand J Immunol Suppl. 1992; 11: 167-70

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