Publikationen Prof. Dr. Klaus Pfeffer

Al-Sakati, H., Kowollik, S., Gabris, S., Balasiu, A., Ommerborn, M., Pfeffer, K., Henrich, B., and Raab, W. H. (2021) The benefit of culture-independent methods to detect bacteria and fungi in re-infected root filled teeth: a pilot study. Int Endod J 54, 74-84

Scharf, S., Bartels, A., Kondakci, M., Haas, R., Pfeffer, K., and Henrich, B. (2021) fuPCR as diagnostic method for the detection of rare fungal pathogens, such as Trichosporon, Cryptococcus and Fusarium. Med Mycol myab045. doi: 10.1093/mmy/myab045.

Walker, A., Houwaart, T., Finzer, P., Ehlkes, L., Tyshaieva, A., Damagnez, M., Strelow, D., Duplessis, A., Nicolai, J., Wienemann, T., Tamayo, T., Kohns Vasconcelos, M., Hulse, L., Hoffmann, K., Lubke, N., Hauka, S., Andree, M., Daumer, M. P., Thielen, A., Kolbe-Busch, S., Gobels, K., Zotz, R., Pfeffer, K., Timm, J., Dilthey, A. T., and German, C.-O. I. (2021) Characterization of SARS-CoV-2 infection clusters based on integrated genomic surveillance, outbreak analysis and contact tracing in an urban setting. Clin Infect Dis

Sorg, U. R., Kupper, N., Mock, J., Tersteegen, A., Petzsch, P., Kohrer, K., Hehlgans, T., and Pfeffer, K. (2021) Lymphotoxin-beta-receptor (LTbetaR) signaling on hepatocytes is required for liver regeneration after partial hepatectomy. Biol Chem 402, 1147-1154

Davegardh, C., Sall, J., Benrick, A., Broholm, C., Volkov, P., Perfilyev, A., Henriksen, T. I., Wu, Y., Hjort, L., Brons, C., Hansson, O., Pedersen, M., Wurthner, J. U., Pfeffer, K., Nilsson, E., Vaag, A., Stener-Victorin, E., Pircs, K., Scheele, C., and Ling, C. (2021) VPS39-deficiency observed in type 2 diabetes impairs muscle stem cell differentiation via altered autophagy and epigenetics. Nat Commun 12, 2431

Merkt, F. K., Mazzone, F., Sazzadeh, S. S., Bonda, L., Hinz, L. K. E., Gruber, I., Buchholz, K., Janiak, C., Pfeffer, K., and Muller, T. J. J. (2021) Fluorescent Indolo[3,2-a]phenazines against Toxoplasma gondii: Concise Synthesis by Gold-Catalyzed Cycloisomerization with 1,2-Silyl Migration and ipso-Iodination Suzuki Sequence. Chemistry 27, 9774-9781

Tersteegen, A., Sorg, U. R., Virgen-Slane, R., Helle, M., Petzsch, P., Dunay, I. R., Kohrer, K., Degrandi, D., Ware, C. F., and Pfeffer, K. (2021) Lymphotoxin beta Receptor: a Crucial Role in Innate and Adaptive Immune Responses against Toxoplasma gondii. Infect Immun 89

Fuchs, A., Tufa, T. B., Horner, J., Hurissa, Z., Nordmann, T., Bosselmann, M., Abdissa, S., Sorsa, A., Orth, H. M., Jensen, B. O., MacKenzie, C., Pfeffer, K., Kaasch, A. J., Bode, J. G., Haussinger, D., and Feldt, T. (2021) Clinical and microbiological characterization of sepsis and evaluation of sepsis scores. PLoS One 16, e0247646

Borst, K., Flindt, S., Blank, P., Larsen, P. K., Chhatbar, C., Skerra, J., Spanier, J., Hirche, C., Konig, M., Alanentalo, T., Hafner, M., Waibler, Z., Pfeffer, K., Sexl, V., Sutter, G., Muller, W., Graalmann, T., and Kalinke, U. (2020) Selective reconstitution of IFNgamma gene function in Ncr1+ NK cells is sufficient to control systemic vaccinia virus infection. PLoS Pathog 16, e1008279

Guendel, F., Kofoed-Branzk, M., Gronke, K., Tizian, C., Witkowski, M., Cheng, H. W., Heinz, G. A., Heinrich, F., Durek, P., Norris, P. S., Ware, C. F., Ruedl, C., Herold, S., Pfeffer, K., Hehlgans, T., Waisman, A., Becher, B., Giannou, A. D., Brachs, S., Ebert, K., Tanriver, Y., Ludewig, B., Mashreghi, M. F., Kruglov, A. A., and Diefenbach, A. (2020) Group 3 Innate Lymphoid Cells Program a Distinct Subset of IL-22BP-Producing Dendritic Cells Demarcating Solitary Intestinal Lymphoid Tissues. Immunity 53, 1015-1032 e1018

Henrich, B., Hammerlage, S., Scharf, S., Haberhausen, D., Furnkranz, U., Kohrer, K., Peitzmann, L., Fiori, P. L., Spergser, J., Pfeffer, K., and Dilthey, A. T. (2020) Characterisation of mobile genetic elements in Mycoplasma hominis with the description of ICEHo-II, a variant mycoplasma integrative and conjugative element. Mob DNA 11, 30

Matsuyama, T., Kubli, S. P., Yoshinaga, S. K., Pfeffer, K., and Mak, T. W. (2020) An aberrant STAT pathway is central to COVID-19. Cell Death Differ 27, 3209-3225

Scharf, S., Bartels, A., Kondakci, M., Pfeffer, K., Henrich, B., and Haas, R. (2020) Introduction of a bead beating step improves fungal DNA extraction from selected patient specimens. Int J Med Microbiol 310, 151443

Schick, J., Schafer, J., Alexander, C., Dichtl, S., Murray, P. J., Christensen, D., Sorg, U., Pfeffer, K., Schleicher, U., and Lang, R. (2020) Cutting Edge: TNF Is Essential for Mycobacteria-Induced MINCLE Expression, Macrophage Activation, and Th17 Adjuvanticity. J Immunol 205, 323-328

Steffens, N., Beuter-Gunia, C., Kravets, E., Reich, A., Legewie, L., Pfeffer, K., and Degrandi, D. (2020) Essential Role of mGBP7 for Survival of Toxoplasma gondii Infection. mBio 11

Tufa, T. B., Fuchs, A., Feldt, T., Galata, D. T., Mackenzie, C. R., Pfeffer, K., and Haussinger, D. (2020) CTX-M-9 group ESBL-producing Raoultella planticola nosocomial infection: first report from sub-Saharan Africa. Ann Clin Microbiol Antimicrob 19, 36

Tufa, T. B., Fuchs, A., Wienemann, T., Eggers, Y., Abdissa, S., Schneider, M., Jensen, B. O., Bode, J. G., Pfeffer, K., Haussinger, D., Mackenzie, C. R., Orth, H. M., and Feldt, T. (2020) Carriage of ESBL-producing Gram-negative bacteria by flies captured in a hospital and its suburban surroundings in Ethiopia. Antimicrob Resist Infect Control 9, 175

van Geelen, L., Kaschani, F., Sazzadeh, S. S., Adeniyi, E. T., Meier, D., Proksch, P., Pfeffer, K., Kaiser, M., Ioerger, T. R., and Kalscheuer, R. (2020) Natural brominated phenoxyphenols kill persistent and biofilm-incorporated cells of MRSA and other pathogenic bacteria. Appl Microbiol Biotechnol 104, 5985-5998

Walker, A., Houwaart, T., Wienemann, T., Vasconcelos, M. K., Strelow, D., Senff, T., Hulse, L., Adams, O., Andree, M., Hauka, S., Feldt, T., Jensen, B. E., Keitel, V., Kindgen-Milles, D., Timm, J., Pfeffer, K., and Dilthey, A. T. (2020) Genetic structure of SARS-CoV-2 reflects clonal superspreading and multiple independent introduction events, North-Rhine Westphalia, Germany, February and March 2020. Euro Surveill 25

Zhuang, Y., Xu, H. C., Shinde, P. V., Warfsmann, J., Vasilevska, J., Sundaram, B., Behnke, K., Huang, J., Hoell, J. I., Borkhardt, A., Pfeffer, K., Taha, M. S., Herebian, D., Mayatepek, E., Brenner, D., Ahmadian, M. R., Keitel, V., Wieczorek, D., Haussinger, D., Pandyra, A. A., Lang, K. S., and Lang, P. A. (2020) Fragile X mental retardation protein protects against tumour necrosis factor-mediated cell death and liver injury. Gut 69, 133-145

Cheng, H. W., Onder, L., Novkovic, M., Soneson, C., Lutge, M., Pikor, N., Scandella, E., Robinson, M. D., Miyazaki, J. I., Tersteegen, A., Sorg, U., Pfeffer, K., Rulicke, T., Hehlgans, T., and Ludewig, B. (2019) Origin and differentiation trajectories of fibroblastic reticular cells in the splenic white pulp. Nat Commun 10, 1739

Fazel Modares, N., Polz, R., Haghighi, F., Lamertz, L., Behnke, K., Zhuang, Y., Kordes, C., Haussinger, D., Sorg, U. R., Pfeffer, K., Floss, D. M., Moll, J. M., Piekorz, R. P., Ahmadian, M. R., Lang, P. A., and Scheller, J. (2019) IL-6 Trans-signaling Controls Liver Regeneration After Partial Hepatectomy. Hepatology 70, 2075-2091

Hillebrand, F., Ostermann, P. N., Muller, L., Degrandi, D., Erkelenz, S., Widera, M., Pfeffer, K., and Schaal, H. (2019) Gymnotic Delivery of LNA Mixmers Targeting Viral SREs Induces HIV-1 mRNA Degradation. Int J Mol Sci 20

Kukuk, L., Dingley, A. J., Granzin, J., Nagel-Steger, L., Thiagarajan-Rosenkranz, P., Ciupka, D., Hanel, K., Batra-Safferling, R., Pacheco, V., Stoldt, M., Pfeffer, K., Beer-Hammer, S., Willbold, D., and Koenig, B. W. (2019) Structure of the SLy1 SAM homodimer reveals a new interface for SAM domain self-association. Sci Rep 9, 54

Legewie, L., Loschwitz, J., Steffens, N., Prescher, M., Wang, X., Smits, S. H. J., Schmitt, L., Strodel, B., Degrandi, D., and Pfeffer, K. (2019) Biochemical and structural characterization of murine GBP7, a guanylate binding protein with an elongated C-terminal tail. Biochem J 476, 3161-3182

Soysa, R., Lampert, S., Yuen, S., Douglass, A. N., Li, W., Pfeffer, K., and Crispe, I. N. (2019) Fetal origin confers radioresistance on liver macrophages via p21(cip1/WAF1). J Hepatol 71, 553-562

Beer-Hammer, S., Lee, S. C., Mauriac, S. A., Leiss, V., Groh, I. A. M., Novakovic, A., Piekorz, R. P., Bucher, K., Chen, C., Ni, K., Singer, W., Harasztosi, C., Schimmang, T., Zimmermann, U., Pfeffer, K., Birnbaumer, L., Forge, A., Montcouquiol, M., Knipper, M., Nurnberg, B., and Ruttiger, L. (2018) Galphai Proteins are Indispensable for Hearing. Cell Physiol Biochem 47, 1509-1532

Behnke, K., Zhuang, Y., Xu, H. C., Sundaram, B., Reich, M., Shinde, P. V., Huang, J., Modares, N. F., Tumanov, A. V., Polz, R., Scheller, J., Ware, C. F., Pfeffer, K., Keitel, V., Haussinger, D., Pandyra, A. A., Lang, K. S., and Lang, P. A. (2018) B Cell-Mediated Maintenance of Cluster of Differentiation 169-Positive Cells Is Critical for Liver Regeneration. Hepatology 68, 2348-2361

Otgonjargal, B., Batbaatar, G., Pfeffer, K., Bruhn, T., Battogtokh, C., and Henrich, B. (2018) A novel mba-based Real time PCR approach for genotyping of Ureaplasma parvum validated in a cohort of Mongolian mothers and offspring. Int J Med Microbiol 308, 865-871

Santos, J. C., Dick, M. S., Lagrange, B., Degrandi, D., Pfeffer, K., Yamamoto, M., Meunier, E., Pelczar, P., Henry, T., and Broz, P. (2018) LPS targets host guanylate-binding proteins to the bacterial outer membrane for non-canonical inflammasome activation. EMBO J 37

Shinde, P. V., Xu, H. C., Maney, S. K., Kloetgen, A., Namineni, S., Zhuang, Y., Honke, N., Shaabani, N., Bellora, N., Doerrenberg, M., Trilling, M., Pozdeev, V. I., van Rooijen, N., Scheu, S., Pfeffer, K., Crocker, P. R., Tanaka, M., Duggimpudi, S., Knolle, P., Heikenwalder, M., Ruland, J., Mak, T. W., Brenner, D., Pandyra, A. A., Hoell, J. I., Borkhardt, A., Haussinger, D., Lang, K. S., and Lang, P. A. (2018) Tumor Necrosis Factor-Mediated Survival of CD169(+) Cells Promotes Immune Activation during Vesicular Stomatitis Virus Infection. J Virol 92

Wang, S., Ljubimov, A. V., Jin, L., Pfeffer, K., Kronenberg, M., and Ghiasi, H. (2018) Herpes Simplex Virus 1 Latency and the Kinetics of Reactivation Are Regulated by a Complex Network of Interactions between the Herpesvirus Entry Mediator, Its Ligands (gD, BTLA, LIGHT, and CD160), and the Latency-Associated Transcript. J Virol 92

Wendel, A. F., Meyer, S., Deenen, R., Kohrer, K., Kolbe-Busch, S., Pfeffer, K., Willmann, M., Kaasch, A. J., and MacKenzie, C. R. (2018) Long-Term, Low-Frequency Cluster of a German-Imipenemase-1-Producing Enterobacter hormaechei ssp. steigerwaltii ST89 in a Tertiary Care Hospital in Germany. Microb Drug Resist 24, 1305-1315

Behnke, K., Sorg, U. R., Gabbert, H. E., and Pfeffer, K. (2017) The Lymphotoxin beta Receptor Is Essential for Upregulation of IFN-Induced Guanylate-Binding Proteins and Survival after Toxoplasma gondii Infection. Mediators Inflamm 2017, 7375818

Lindenberg, V., Molleken, K., Kravets, E., Stallmann, S., Hegemann, J. H., Degrandi, D., and Pfeffer, K. (2017) Broad recruitment of mGBP family members to Chlamydia trachomatis inclusions. PLoS One 12, e0185273

Onder, L., Morbe, U., Pikor, N., Novkovic, M., Cheng, H. W., Hehlgans, T., Pfeffer, K., Becher, B., Waisman, A., Rulicke, T., Gommerman, J., Mueller, C. G., Sawa, S., Scandella, E., and Ludewig, B. (2017) Lymphatic Endothelial Cells Control Initiation of Lymph Node Organogenesis. Immunity 47, 80-92 e84

Otgonjargala, B., Becker, K., Batbaatar, G., Tsogtsaikhan, S., Enkhtsetseg, J., Enkhjargal, A., Pfeffer, K., Adams, O., Battogtokh, C., and Henrich, B. (2017) Effect of Mycoplasma hominis and cytomegalovirus infection on pregnancy outcome: A prospective study of 200 Mongolian women and their newborns. PLoS One 12, e0173283

Pozdeev, V. I., Lang, E., Gorg, B., Bidmon, H. J., Shinde, P. V., Kircheis, G., Herebian, D., Pfeffer, K., Lang, F., Haussinger, D., Lang, K. S., and Lang, P. A. (2017) TNFalpha induced up-regulation of Na(+),K(+),2Cl(-) cotransporter NKCC1 in hepatic ammonia clearance and cerebral ammonia toxicity. Sci Rep 7, 7938

Wendel, A. F., Kaase, M., Autenrieth, I. B., Peter, S., Oberhettinger, P., Rieber, H., Pfeffer, K., MacKenzie, C. R., and Willmann, M. (2017) Protracted Regional Dissemination of GIM-1-Producing Serratia marcescens in Western Germany. Antimicrob Agents Chemother 61

Baljin, B., Baldan, G., Chimeddorj, B., Tulgaa, K., Gunchin, B., Sandag, T., Pfeffer, K., MacKenzie, C. R., and Wendel, A. F. (2016) Faecal Carriage of Gram-Negative Multidrug-Resistant Bacteria among Patients Hospitalized in Two Centres in Ulaanbaatar, Mongolia. PLoS One 11, e0168146

del Rio, M. L., Fernandez-Renedo, C., Chaloin, O., Scheu, S., Pfeffer, K., Shintani, Y., Perez-Simon, J. A., Schneider, P., and Rodriguez-Barbosa, J. I. (2016) Immunotherapeutic targeting of LIGHT/LTbetaR/HVEM pathway fully recapitulates the reduced cytotoxic phenotype of LIGHT-deficient T cells. MAbs 8, 478-490

Kravets, E., Degrandi, D., Ma, Q., Peulen, T. O., Klumpers, V., Felekyan, S., Kuhnemuth, R., Weidtkamp-Peters, S., Seidel, C. A., and Pfeffer, K. (2016) Guanylate binding proteins directly attack Toxoplasma gondii via supramolecular complexes. Elife 5

Rahn, S., Schuck, A., Kondakci, M., Haas, R., Neuhausen, N., Pfeffer, K., and Henrich, B. (2016) A novel comprehensive set of fungal Real time PCR assays (fuPCR) for the detection of fungi in immunocompromised haematological patients-A pilot study. Int J Med Microbiol 306, 611-623

Sorg, U. R., Behnke, K., Degrandi, D., Reich, M., Keitel, V., Herebian, D., Deenen, R., Beyer, M., Schultze, J. L., Kohrer, K., Gabbert, H. E., Mayatepek, E., Haussinger, D., and Pfeffer, K. (2016) Cooperative role of lymphotoxin beta receptor and tumor necrosis factor receptor p55 in murine liver regeneration. J Hepatol 64, 1108-1117

Wendel, A. F., Ressina, S., Kolbe-Busch, S., Pfeffer, K., and MacKenzie, C. R. (2016) Species Diversity of Environmental GIM-1-Producing Bacteria Collected during a Long-Term Outbreak. Appl Environ Microbiol 82, 3605-3610

Breloer, M., Hartmann, W., Blankenhaus, B., Eschbach, M. L., Pfeffer, K., and Jacobs, T. (2015) Cutting Edge: the BTLA-HVEM regulatory pathway interferes with protective immunity to intestinal Helminth infection. J Immunol 194, 1413-1416

Erkelenz, S., Hillebrand, F., Widera, M., Theiss, S., Fayyaz, A., Degrandi, D., Pfeffer, K., and Schaal, H. (2015) Balanced splicing at the Tat-specific HIV-1 3'ss A3 is critical for HIV-1 replication. Retrovirology 12, 29

Grandoch, M., Feldmann, K., Gothert, J. R., Dick, L. S., Homann, S., Klatt, C., Bayer, J. K., Waldheim, J. N., Rabausch, B., Nagy, N., Oberhuber, A., Deenen, R., Kohrer, K., Lehr, S., Homey, B., Pfeffer, K., and Fischer, J. W. (2015) Deficiency in lymphotoxin beta receptor protects from atherosclerosis in apoE-deficient mice. Circ Res 116, e57-68

Meunier, E., Wallet, P., Dreier, R. F., Costanzo, S., Anton, L., Ruhl, S., Dussurgey, S., Dick, M. S., Kistner, A., Rigard, M., Degrandi, D., Pfeffer, K., Yamamoto, M., Henry, T., and Broz, P. (2015) Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicida. Nat Immunol 16, 476-484

Petermann, P., Thier, K., Rahn, E., Rixon, F. J., Bloch, W., Ozcelik, S., Krummenacher, C., Barron, M. J., Dixon, M. J., Scheu, S., Pfeffer, K., and Knebel-Morsdorf, D. (2015) Entry mechanisms of herpes simplex virus 1 into murine epidermis: involvement of nectin-1 and herpesvirus entry mediator as cellular receptors. J Virol 89, 262-274

Schwarz, F., Becker, K., Rahn, S., Hegewald, A., Pfeffer, K., and Henrich, B. (2015) Real-time PCR analysis of fungal organisms and bacterial species at peri-implantitis sites. Int J Implant Dent 1, 9

Wendel, A. F., Kolbe-Busch, S., Ressina, S., Schulze-Robbecke, R., Kindgen-Milles, D., Lorenz, C., Pfeffer, K., and MacKenzie, C. R. (2015) Detection and termination of an extended low-frequency hospital outbreak of GIM-1-producing Pseudomonas aeruginosa ST111 in Germany. Am J Infect Control 43, 635-639

Aparicio-Siegmund, S., Sommer, J., Monhasery, N., Schwanbeck, R., Keil, E., Finkenstadt, D., Pfeffer, K., Rose-John, S., Scheller, J., and Garbers, C. (2014) Inhibition of protein kinase II (CK2) prevents induced signal transducer and activator of transcription (STAT) 1/3 and constitutive STAT3 activation. Oncotarget 5, 2131-2148

del Rio, M. L., Fernandez-Renedo, C., Scheu, S., Pfeffer, K., Shintani, Y., Kronenberg, M., Chaloin, O., Schneider, P., and Rodriguez-Barbosa, J. I. (2014) Therapeutic blockade of LIGHT interaction with herpesvirus entry mediator and lymphotoxin beta receptor attenuates in vivo cytotoxic allogeneic responses. Transplantation 98, 1165-1174

Globisch, T., Steiner, N., Fulle, L., Lukacs-Kornek, V., Degrandi, D., Dresing, P., Alferink, J., Lang, R., Pfeffer, K., Beyer, M., Weighardt, H., Kurts, C., Ulas, T., Schultze, J. L., and Forster, I. (2014) Cytokine-dependent regulation of dendritic cell differentiation in the splenic microenvironment. Eur J Immunol 44, 500-510

Grusdat, M., McIlwain, D. R., Xu, H. C., Pozdeev, V. I., Knievel, J., Crome, S. Q., Robert-Tissot, C., Dress, R. J., Pandyra, A. A., Speiser, D. E., Lang, E., Maney, S. K., Elford, A. R., Hamilton, S. R., Scheu, S., Pfeffer, K., Bode, J., Mittrucker, H. W., Lohoff, M., Huber, M., Haussinger, D., Ohashi, P. S., Mak, T. W., Lang, K. S., and Lang, P. A. (2014) IRF4 and BATF are critical for CD8(+) T-cell function following infection with LCMV. Cell Death Differ 21, 1050-1060

Keil, E., Finkenstadt, D., Wufka, C., Trilling, M., Liebfried, P., Strobl, B., Muller, M., and Pfeffer, K. (2014) Important scaffold function of the Janus kinase 2 uncovered by a novel mouse model harboring a Jak2 activation-loop mutation. Blood 123, 520-529

Pilla, D. M., Hagar, J. A., Haldar, A. K., Mason, A. K., Degrandi, D., Pfeffer, K., Ernst, R. K., Yamamoto, M., Miao, E. A., and Coers, J. (2014) Guanylate binding proteins promote caspase-11-dependent pyroptosis in response to cytoplasmic LPS. Proc Natl Acad Sci U S A 111, 6046-6051

Trilling, M., Le, V. T., Rashidi-Alavijeh, J., Katschinski, B., Scheller, J., Rose-John, S., Androsiac, G. E., Jonjic, S., Poli, V., Pfeffer, K., and Hengel, H. (2014) "Activated" STAT proteins: a paradoxical consequence of inhibited JAK-STAT signaling in cytomegalovirus-infected cells. J Immunol 192, 447-458

Arpaia, N., Campbell, C., Fan, X., Dikiy, S., van der Veeken, J., deRoos, P., Liu, H., Cross, J. R., Pfeffer, K., Coffer, P. J., and Rudensky, A. Y. (2013) Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation. Nature 504, 451-455

Degrandi, D., Kravets, E., Konermann, C., Beuter-Gunia, C., Klumpers, V., Lahme, S., Wischmann, E., Mausberg, A. K., Beer-Hammer, S., and Pfeffer, K. (2013) Murine guanylate binding protein 2 (mGBP2) controls Toxoplasma gondii replication. Proc Natl Acad Sci U S A 110, 294-299

Gogishvili, T., Luhder, F., Goebbels, S., Beer-Hammer, S., Pfeffer, K., and Hunig, T. (2013) Cell-intrinsic and -extrinsic control of Treg-cell homeostasis and function revealed by induced CD28 deletion. Eur J Immunol 43, 188-193

Keil, E., Hocker, R., Schuster, M., Essmann, F., Ueffing, N., Hoffman, B., Liebermann, D. A., Pfeffer, K., Schulze-Osthoff, K., and Schmitz, I. (2013) Phosphorylation of Atg5 by the Gadd45beta-MEKK4-p38 pathway inhibits autophagy. Cell Death Differ 20, 321-332

Lubben, W., Turqueti-Neves, A., Okhrimenko, A., Stoberl, C., Schmidt, V., Pfeffer, K., Dehnert, S., Wunsche, S., Storsberg, S., Paul, S., Bauer, S., Riethmuller, G., Voehringer, D., and Yu, P. (2013) IgE knock-in mice suggest a role for high levels of IgE in basophil-mediated active systemic anaphylaxis. Eur J Immunol 43, 1231-1242

Lubitz, F. P., Degrandi, D., Pfeffer, K., and Mausberg, A. K. (2013) In astrocytes the accumulation of the immunity-related GTPases Irga6 and Irgb6 at the vacuole of Toxoplasma gondii is dependent on the parasite virulence. ScientificWorldJournal 2013, 480231

Mana, P., Linares, D., Silva, D. G., Fordham, S., Scheu, S., Pfeffer, K., Staykova, M., and Bertram, E. M. (2013) LIGHT (TNFSF14/CD258) is a decisive factor for recovery from experimental autoimmune encephalomyelitis. J Immunol 191, 154-163

Selleck, E. M., Fentress, S. J., Beatty, W. L., Degrandi, D., Pfeffer, K., Virgin, H. W. t., Macmicking, J. D., and Sibley, L. D. (2013) Guanylate-binding protein 1 (Gbp1) contributes to cell-autonomous immunity against Toxoplasma gondii. PLoS Pathog 9, e1003320

Spekker, K., Leineweber, M., Degrandi, D., Ince, V., Brunder, S., Schmidt, S. K., Stuhlsatz, S., Howard, J. C., Schares, G., Degistirici, O., Meisel, R., Sorg, R. V., Seissler, J., Hemphill, A., Pfeffer, K., and Daubener, W. (2013) Antimicrobial effects of murine mesenchymal stromal cells directed against Toxoplasma gondii and Neospora caninum: role of immunity-related GTPases (IRGs) and guanylate-binding proteins (GBPs). Med Microbiol Immunol 202, 197-206

Wendel, A. F., Brodner, A. H., Wydra, S., Ressina, S., Henrich, B., Pfeffer, K., Toleman, M. A., and Mackenzie, C. R. (2013) Genetic characterization and emergence of the metallo-beta-lactamase GIM-1 in Pseudomonas spp. and Enterobacteriaceae during a long-term outbreak. Antimicrob Agents Chemother 57, 5162-5165

Ellinger, P., Arslan, Z., Wurm, R., Tschapek, B., MacKenzie, C., Pfeffer, K., Panjikar, S., Wagner, R., Schmitt, L., Gohlke, H., Pul, U., and Smits, S. H. (2012) The crystal structure of the CRISPR-associated protein Csn2 from Streptococcus agalactiae. J Struct Biol 178, 350-362

Gais, P., Reim, D., Jusek, G., Rossmann-Bloeck, T., Weighardt, H., Pfeffer, K., Altmayr, F., Janssen, K. P., and Holzmann, B. (2012) Cutting edge: Divergent cell-specific functions of MyD88 for inflammatory responses and organ injury in septic peritonitis. J Immunol 188, 5833-5837

Gogishvili, T., Luhder, F., Kirstein, F., Nieuwenhuizen, N. E., Goebbels, S., Beer-Hammer, S., Pfeffer, K., Reuter, S., Taube, C., Brombacher, F., and Hunig, T. (2012) Interruption of CD28-mediated costimulation during allergen challenge protects mice from allergic airway disease. J Allergy Clin Immunol 130, 1394-1403 e1394

Kravets, E., Degrandi, D., Weidtkamp-Peters, S., Ries, B., Konermann, C., Felekyan, S., Dargazanli, J. M., Praefcke, G. J., Seidel, C. A., Schmitt, L., Smits, S. H., and Pfeffer, K. (2012) The GTPase activity of murine guanylate-binding protein 2 (mGBP2) controls the intracellular localization and recruitment to the parasitophorous vacuole of Toxoplasma gondii. J Biol Chem 287, 27452-27466

Schuster, M., Glauben, R., Plaza-Sirvent, C., Schreiber, L., Annemann, M., Floess, S., Kuhl, A. A., Clayton, L. K., Sparwasser, T., Schulze-Osthoff, K., Pfeffer, K., Huehn, J., Siegmund, B., and Schmitz, I. (2012) IkappaB(NS) protein mediates regulatory T cell development via induction of the Foxp3 transcription factor. Immunity 37, 998-1008

Wimmer, N., Huber, B., Barabas, N., Rohrl, J., Pfeffer, K., and Hehlgans, T. (2012) Lymphotoxin beta receptor activation on macrophages induces cross-tolerance to TLR4 and TLR9 ligands. J Immunol 188, 3426-3433

Wimmer, N., Huber, B., Wege, A. K., Barabas, N., Rohrl, J., Pfeffer, K., and Hehlgans, T. (2012) Lymphotoxin-beta receptor activation on macrophages ameliorates acute DSS-induced intestinal inflammation in a TRIM30alpha-dependent manner. Mol Immunol 51, 128-135

Adler, G., Steeg, C., Pfeffer, K., Murphy, T. L., Murphy, K. M., Langhorne, J., and Jacobs, T. (2011) B and T lymphocyte attenuator restricts the protective immune response against experimental malaria. J Immunol 187, 5310-5319

Doherty, T. A., Soroosh, P., Khorram, N., Fukuyama, S., Rosenthal, P., Cho, J. Y., Norris, P. S., Choi, H., Scheu, S., Pfeffer, K., Zuraw, B. L., Ware, C. F., Broide, D. H., and Croft, M. (2011) The tumor necrosis factor family member LIGHT is a target for asthmatic airway remodeling. Nat Med 17, 596-603

Honke, N., Shaabani, N., Cadeddu, G., Sorg, U. R., Zhang, D. E., Trilling, M., Klingel, K., Sauter, M., Kandolf, R., Gailus, N., van Rooijen, N., Burkart, C., Baldus, S. E., Grusdat, M., Lohning, M., Hengel, H., Pfeffer, K., Tanaka, M., Haussinger, D., Recher, M., Lang, P. A., and Lang, K. S. (2011) Enforced viral replication activates adaptive immunity and is essential for the control of a cytopathic virus. Nat Immunol 13, 51-57

Kendall, G. S., Hristova, M., Horn, S., Dafou, D., Acosta-Saltos, A., Almolda, B., Zbarsky, V., Rumajogee, P., Heuer, H., Castellano, B., Pfeffer, K., Nedospasov, S. A., Peebles, D. M., and Raivich, G. (2011) TNF gene cluster deletion abolishes lipopolysaccharide-mediated sensitization of the neonatal brain to hypoxic ischemic insult. Lab Invest 91, 328-341

Messler, S., Kropp, S., Episkopou, V., Felici, A., Wurthner, J., Lemke, R., Jerabek-Willemsen, M., Willecke, R., Scheu, S., Pfeffer, K., and Wurthner, J. U. (2011) The TGF-beta signaling modulators TRAP1/TGFBRAP1 and VPS39/Vam6/TLP are essential for early embryonic development. Immunobiology 216, 343-350

Soroosh, P., Doherty, T. A., So, T., Mehta, A. K., Khorram, N., Norris, P. S., Scheu, S., Pfeffer, K., Ware, C., and Croft, M. (2011) Herpesvirus entry mediator (TNFRSF14) regulates the persistence of T helper memory cell populations. J Exp Med 208, 797-809

Stanley, A. C., de Labastida Rivera, F., Haque, A., Sheel, M., Zhou, Y., Amante, F. H., Bunn, P. T., Randall, L. M., Pfeffer, K., Scheu, S., Hickey, M. J., Saunders, B. M., Ware, C., Hill, G. R., Tamada, K., Kaye, P. M., and Engwerda, C. R. (2011) Critical roles for LIGHT and its receptors in generating T cell-mediated immunity during Leishmania donovani infection. PLoS Pathog 7, e1002279

Traver, M. K., Henry, S. C., Cantillana, V., Oliver, T., Hunn, J. P., Howard, J. C., Beer, S., Pfeffer, K., Coers, J., and Taylor, G. A. (2011) Immunity-related GTPase M (IRGM) proteins influence the localization of guanylate-binding protein 2 (GBP2) by modulating macroautophagy. J Biol Chem 286, 30471-30480

Beer-Hammer, S., Zebedin, E., von Holleben, M., Alferink, J., Reis, B., Dresing, P., Degrandi, D., Scheu, S., Hirsch, E., Sexl, V., Pfeffer, K., Nurnberg, B., and Piekorz, R. P. (2010) The catalytic PI3K isoforms p110gamma and p110delta contribute to B cell development and maintenance, transformation, and proliferation. J Leukoc Biol 87, 1083-1095

Benezech, C., White, A., Mader, E., Serre, K., Parnell, S., Pfeffer, K., Ware, C. F., Anderson, G., and Caamano, J. H. (2010) Ontogeny of stromal organizer cells during lymph node development. J Immunol 184, 4521-4530

Hardegen, C., Messler, S., Henrich, B., Pfeffer, K., Wurthner, J., and MacKenzie, C. R. (2010) A set of novel multiplex Taqman real-time PCRs for the detection of diarrhoeagenic Escherichia coli and its use in determining the prevalence of EPEC and EAEC in a university hospital. Ann Clin Microbiol Antimicrob 9, 5

Henrich, B., Schmitt, M., Bergmann, N., Zanger, K., Kubitz, R., Haussinger, D., and Pfeffer, K. (2010) Mycoplasma salivarium detected in a microbial community with Candida glabrata in the biofilm of an occluded biliary stent. J Med Microbiol 59, 239-241

White, A. J., Nakamura, K., Jenkinson, W. E., Saini, M., Sinclair, C., Seddon, B., Narendran, P., Pfeffer, K., Nitta, T., Takahama, Y., Caamano, J. H., Lane, P. J., Jenkinson, E. J., and Anderson, G. (2010) Lymphotoxin signals from positively selected thymocytes regulate the terminal differentiation of medullary thymic epithelial cells. J Immunol 185, 4769-4776

Cheung, T. C., Oborne, L. M., Steinberg, M. W., Macauley, M. G., Fukuyama, S., Sanjo, H., D'Souza, C., Norris, P. S., Pfeffer, K., Murphy, K. M., Kronenberg, M., Spear, P. G., and Ware, C. F. (2009) T cell intrinsic heterodimeric complexes between HVEM and BTLA determine receptivity to the surrounding microenvironment. J Immunol 183, 7286-7296

Cheung, T. C., Steinberg, M. W., Oborne, L. M., Macauley, M. G., Fukuyama, S., Sanjo, H., D'Souza, C., Norris, P. S., Pfeffer, K., Murphy, K. M., Kronenberg, M., Spear, P. G., and Ware, C. F. (2009) Unconventional ligand activation of herpesvirus entry mediator signals cell survival. Proc Natl Acad Sci U S A 106, 6244-6249

Degrandi, D., Hoffmann, R., Beuter-Gunia, C., and Pfeffer, K. (2009) The proinflammatory cytokine-induced IRG1 protein associates with mitochondria. J Interferon Cytokine Res 29, 55-67

Forster, M., Sievert, K., Messler, S., Klimpel, S., and Pfeffer, K. (2009) Comprehensive study on the occurrence and distribution of pathogenic microorganisms carried by synanthropic flies caught at different rural locations in Germany. J Med Entomol 46, 1164-1166

Kneilling, M., Mailhammer, R., Hultner, L., Schonberger, T., Fuchs, K., Schaller, M., Bukala, D., Massberg, S., Sander, C. A., Braumuller, H., Eichner, M., Maier, K. L., Hallmann, R., Pichler, B. J., Haubner, R., Gawaz, M., Pfeffer, K., Biedermann, T., and Rocken, M. (2009) Direct crosstalk between mast cell-TNF and TNFR1-expressing endothelia mediates local tissue inflammation. Blood 114, 1696-1706

Reis, B., Pfeffer, K., and Beer-Hammer, S. (2009) The orphan adapter protein SLY1 as a novel anti-apoptotic protein required for thymocyte development. BMC Immunol 10, 38

Scheikl, T., Reis, B., Pfeffer, K., Holzmann, B., and Beer, S. (2009) Reduced notch activity is associated with an impaired marginal zone B cell development and function in Sly1 mutant mice. Mol Immunol 46, 969-977

Sun, Y., Brown, N. K., Ruddy, M. J., Miller, M. L., Lee, Y., Wang, Y., Murphy, K. M., Pfeffer, K., Chen, L., Kaye, J., and Fu, Y. X. (2009) B and T lymphocyte attenuator tempers early infection immunity. J Immunol 183, 1946-1951

Trilling, M., Le, V. T., Zimmermann, A., Ludwig, H., Pfeffer, K., Sutter, G., Smith, G. L., and Hengel, H. (2009) Gamma interferon-induced interferon regulatory factor 1-dependent antiviral response inhibits vaccinia virus replication in mouse but not human fibroblasts. J Virol 83, 3684-3695

De Trez, C., Schneider, K., Potter, K., Droin, N., Fulton, J., Norris, P. S., Ha, S. W., Fu, Y. X., Murphy, T., Murphy, K. M., Pfeffer, K., Benedict, C. A., and Ware, C. F. (2008) The inhibitory HVEM-BTLA pathway counter regulates lymphotoxin receptor signaling to achieve homeostasis of dendritic cells. J Immunol 180, 238-248

Grebien, F., Kerenyi, M. A., Kovacic, B., Kolbe, T., Becker, V., Dolznig, H., Pfeffer, K., Klingmuller, U., Muller, M., Beug, H., Mullner, E. W., and Moriggl, R. (2008) Stat5 activation enables erythropoiesis in the absence of EpoR and Jak2. Blood 111, 4511-4522

Kresse, A., Konermann, C., Degrandi, D., Beuter-Gunia, C., Wuerthner, J., Pfeffer, K., and Beer, S. (2008) Analyses of murine GBP homology clusters based on in silico, in vitro and in vivo studies. BMC Genomics 9, 158

Kursar, M., Janner, N., Pfeffer, K., Brinkmann, V., Kaufmann, S. H., and Mittrucker, H. W. (2008) Requirement of secondary lymphoid tissues for the induction of primary and secondary T cell responses against Listeria monocytogenes. Eur J Immunol 38, 127-138

Kutsch, S., Degrandi, D., and Pfeffer, K. (2008) Immediate lymphotoxin beta receptor-mediated transcriptional response in host defense against L. monocytogenes. Immunobiology 213, 353-366

Randall, L. M., Amante, F. H., Zhou, Y., Stanley, A. C., Haque, A., Rivera, F., Pfeffer, K., Scheu, S., Hill, G. R., Tamada, K., and Engwerda, C. R. (2008) Cutting edge: selective blockade of LIGHT-lymphotoxin beta receptor signaling protects mice from experimental cerebral malaria caused by Plasmodium berghei ANKA. J Immunol 181, 7458-7462

Schneider, K., Loewendorf, A., De Trez, C., Fulton, J., Rhode, A., Shumway, H., Ha, S., Patterson, G., Pfeffer, K., Nedospasov, S. A., Ware, C. F., and Benedict, C. A. (2008) Lymphotoxin-mediated crosstalk between B cells and splenic stroma promotes the initial type I interferon response to cytomegalovirus. Cell Host Microbe 3, 67-76

Steinberg, M. W., Turovskaya, O., Shaikh, R. B., Kim, G., McCole, D. F., Pfeffer, K., Murphy, K. M., Ware, C. F., and Kronenberg, M. (2008) A crucial role for HVEM and BTLA in preventing intestinal inflammation. J Exp Med 205, 1463-1476

Togbe, D., de Sousa, P. L., Fauconnier, M., Boissay, V., Fick, L., Scheu, S., Pfeffer, K., Menard, R., Grau, G. E., Doan, B. T., Beloeil, J. C., Renia, L., Hansen, A. M., Ball, H. J., Hunt, N. H., Ryffel, B., and Quesniaux, V. F. (2008) Both functional LTbeta receptor and TNF receptor 2 are required for the development of experimental cerebral malaria. PLoS One 3, e2608

Traeger, T., Kessler, W., Assfalg, V., Cziupka, K., Koerner, P., Dassow, C., Breitbach, K., Mikulcak, M., Steinmetz, I., Pfeffer, K., Heidecke, C. D., and Maier, S. (2008) Detrimental role of CC chemokine receptor 4 in murine polymicrobial sepsis. Infect Immun 76, 5285-5293

Vallabhapurapu, S., Powolny-Budnicka, I., Riemann, M., Schmid, R. M., Paxian, S., Pfeffer, K., Korner, H., and Weih, F. (2008) Rel/NF-kappaB family member RelA regulates NK1.1- to NK1.1+ transition as well as IL-15-induced expansion of NKT cells. Eur J Immunol 38, 3508-3519

Yang, J., Hills, D., Taylor, E., Pfeffer, K., Ure, J., and Medvinsky, A. (2008) Transgenic tools for analysis of the haematopoietic system: knock-in CD45 reporter and deletor mice. J Immunol Methods 337, 81-87

Degrandi, D., Konermann, C., Beuter-Gunia, C., Kresse, A., Wurthner, J., Kurig, S., Beer, S., and Pfeffer, K. (2007) Extensive characterization of IFN-induced GTPases mGBP1 to mGBP10 involved in host defense. J Immunol 179, 7729-7740

Forster, M., Klimpel, S., Mehlhorn, H., Sievert, K., Messler, S., and Pfeffer, K. (2007) Pilot study on synanthropic flies (e.g. Musca, Sarcophaga, Calliphora, Fannia, Lucilia, Stomoxys) as vectors of pathogenic microorganisms. Parasitol Res 101, 243-246

Hoff, N. P., Degrandi, D., Hengge, U., Pfeffer, K., and Wurthner, J. U. (2007) Carboxypeptidase D: a novel TGF-beta target gene dysregulated in patients with lupus erythematosus. J Clin Immunol 27, 568-579

Konermann, C., Kresse, A., Beuter-Gunia, C., Wurthner, J., Degrandi, D., Pfeffer, K., and Beer, S. (2007) In silico and in vitro characterization of mGBP4 splice variants. DNA Cell Biol 26, 847-851

Lepenies, B., Pfeffer, K., Hurchla, M. A., Murphy, T. L., Murphy, K. M., Oetzel, J., Fleischer, B., and Jacobs, T. (2007) Ligation of B and T lymphocyte attenuator prevents the genesis of experimental cerebral malaria. J Immunol 179, 4093-4100

Rebholz, B., Haase, I., Eckelt, B., Paxian, S., Flaig, M. J., Ghoreschi, K., Nedospasov, S. A., Mailhammer, R., Debey-Pascher, S., Schultze, J. L., Weindl, G., Forster, I., Huss, R., Stratis, A., Ruzicka, T., Rocken, M., Pfeffer, K., Schmid, R. M., and Rupec, R. A. (2007) Crosstalk between keratinocytes and adaptive immune cells in an IkappaBalpha protein-mediated inflammatory disease of the skin. Immunity 27, 296-307

Spiller, S., Dreher, S., Meng, G., Grabiec, A., Thomas, W., Hartung, T., Pfeffer, K., Hochrein, H., Brade, H., Bessler, W., Wagner, H., and Kirschning, C. J. (2007) Cellular recognition of trimyristoylated peptide or enterobacterial lipopolysaccharide via both TLR2 and TLR4. J Biol Chem 282, 13190-13198

Summers-DeLuca, L. E., McCarthy, D. D., Cosovic, B., Ward, L. A., Lo, C. C., Scheu, S., Pfeffer, K., and Gommerman, J. L. (2007) Expression of lymphotoxin-alphabeta on antigen-specific T cells is required for DC function. J Exp Med 204, 1071-1081

Taylor, J. M., Lin, E., Susmarski, N., Yoon, M., Zago, A., Ware, C. F., Pfeffer, K., Miyoshi, J., Takai, Y., and Spear, P. G. (2007) Alternative entry receptors for herpes simplex virus and their roles in disease. Cell Host Microbe 2, 19-28

Virtej, A., MacKenzie, C. R., Raab, W. H., Pfeffer, K., and Barthel, C. R. (2007) Determination of the performance of various root canal disinfection methods after in situ carriage. J Endod 33, 926-929

Entleutner, M., Traeger, T., Westerholt, A., Holzmann, B., Stier, A., Pfeffer, K., Maier, S., and Heidecke, C. D. (2006) Impact of interleukin-12, oxidative burst, and iNOS on the survival of murine fecal peritonitis. Int J Colorectal Dis 21, 64-70

Hengge, U. R., Scharf, R. E., Kroon, F. P., and Pfeffer, K. (2006) Severe serum sickness following pneumococcal vaccination in an AIDS patient. Int J STD AIDS 17, 210-211

Kolsch, U., Arndt, B., Reinhold, D., Lindquist, J. A., Juling, N., Kliche, S., Pfeffer, K., Bruyns, E., Schraven, B., and Simeoni, L. (2006) Normal T-cell development and immune functions in TRIM-deficient mice. Mol Cell Biol 26, 3639-3648

Milicevic, N. M., Nohroudi, K., Labudovic-Borovic, M., Milicevic, Z., Pfeffer, K., and Westermann, J. (2006) Metallophilic macrophages are lacking in the thymus of lymphotoxin-beta receptor-deficient mice. Histochem Cell Biol 126, 687-693

Sandqvist, A., Kalies, H., Siedler, A., Grondahl, B., Schmitt, H. J., Schweitzer-Krantz, S., Messing-Junger, M., Pfeffer, K., Mayatepek, E., von Kries, R., and Schroten, H. (2006) Invasive nontypeable Haemophilus influenzae infections in Germany: a case report of a previously healthy 7-year-old boy with an intracranial abscess, and epidemiological data from 2001 to 2004. Eur J Pediatr 165, 658-659

Sedgmen, B. J., Dawicki, W., Gommerman, J. L., Pfeffer, K., and Watts, T. H. (2006) LIGHT is dispensable for CD4+ and CD8+ T cell and antibody responses to influenza A virus in mice. Int Immunol 18, 797-806

Warskulat, U., Borsch, E., Reinehr, R., Heller-Stilb, B., Monnighoff, I., Buchczyk, D., Donner, M., Flogel, U., Kappert, G., Soboll, S., Beer, S., Pfeffer, K., Marschall, H. U., Gabrielsen, M., Amiry-Moghaddam, M., Ottersen, O. P., Dienes, H. P., and Haussinger, D. (2006) Chronic liver disease is triggered by taurine transporter knockout in the mouse. FASEB J 20, 574-576

Anders, R. A., Subudhi, S. K., Wang, J., Pfeffer, K., and Fu, Y. X. (2005) Contribution of the lymphotoxin beta receptor to liver regeneration. J Immunol 175, 1295-1300

Banks, T. A., Rickert, S., Benedict, C. A., Ma, L., Ko, M., Meier, J., Ha, W., Schneider, K., Granger, S. W., Turovskaya, O., Elewaut, D., Otero, D., French, A. R., Henry, S. C., Hamilton, J. D., Scheu, S., Pfeffer, K., and Ware, C. F. (2005) A lymphotoxin-IFN-beta axis essential for lymphocyte survival revealed during cytomegalovirus infection. J Immunol 174, 7217-7225

Beer, S., Scheikl, T., Reis, B., Huser, N., Pfeffer, K., and Holzmann, B. (2005) Impaired immune responses and prolonged allograft survival in Sly1 mutant mice. Mol Cell Biol 25, 9646-9660

Benyo, Z., Gille, A., Kero, J., Csiky, M., Suchankova, M. C., Nusing, R. M., Moers, A., Pfeffer, K., and Offermanns, S. (2005) GPR109A (PUMA-G/HM74A) mediates nicotinic acid-induced flushing. J Clin Invest 115, 3634-3640

Hapfelmeier, S., Stecher, B., Barthel, M., Kremer, M., Muller, A. J., Heikenwalder, M., Stallmach, T., Hensel, M., Pfeffer, K., Akira, S., and Hardt, W. D. (2005) The Salmonella pathogenicity island (SPI)-2 and SPI-1 type III secretion systems allow Salmonella serovar typhimurium to trigger colitis via MyD88-dependent and MyD88-independent mechanisms. J Immunol 174, 1675-1685

Hehlgans, T., and Pfeffer, K. (2005) The intriguing biology of the tumour necrosis factor/tumour necrosis factor receptor superfamily: players, rules and the games. Immunology 115, 1-20

Huser, N., Tertilt, C., Gerauer, K., Maier, S., Traeger, T., Assfalg, V., Reiter, R., Heidecke, C. D., and Pfeffer, K. (2005) CCR4-deficient mice show prolonged graft survival in a chronic cardiac transplant rejection model. Eur J Immunol 35, 128-138

Klose, R., Kemter, E., Bedke, T., Bittmann, I., Kelsser, B., Endres, R., Pfeffer, K., Schwinzer, R., and Wolf, E. (2005) Expression of biologically active human TRAIL in transgenic pigs. Transplantation 80, 222-230

Liu, Z. Q., Bohatschek, M., Pfeffer, K., Bluethmann, H., and Raivich, G. (2005) Major histocompatibility complex (MHC2+) perivascular macrophages in the axotomized facial motor nucleus are regulated by receptors for interferon-gamma (IFNgamma) and tumor necrosis factor (TNF). Neuroscience 131, 283-292

Perez de Lema, G., Maier, H., Franz, T. J., Escribese, M., Chilla, S., Segerer, S., Camarasa, N., Schmid, H., Banas, B., Kalaydjiev, S., Busch, D. H., Pfeffer, K., Mampaso, F., Schlondorff, D., and Luckow, B. (2005) Chemokine receptor Ccr2 deficiency reduces renal disease and prolongs survival in MRL/lpr lupus-prone mice. J Am Soc Nephrol 16, 3592-3601

Riemann, M., Endres, R., Liptay, S., Pfeffer, K., and Schmid, R. M. (2005) The IkappaB protein Bcl-3 negatively regulates transcription of the IL-10 gene in macrophages. J Immunol 175, 3560-3568

Rupec, R. A., Jundt, F., Rebholz, B., Eckelt, B., Weindl, G., Herzinger, T., Flaig, M. J., Moosmann, S., Plewig, G., Dorken, B., Forster, I., Huss, R., and Pfeffer, K. (2005) Stroma-mediated dysregulation of myelopoiesis in mice lacking I kappa B alpha. Immunity 22, 479-491

Sedy, J. R., Gavrieli, M., Potter, K. G., Hurchla, M. A., Lindsley, R. C., Hildner, K., Scheu, S., Pfeffer, K., Ware, C. F., Murphy, T. L., and Murphy, K. M. (2005) B and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirus entry mediator. Nat Immunol 6, 90-98

Semmrich, M., Smith, A., Feterowski, C., Beer, S., Engelhardt, B., Busch, D. H., Bartsch, B., Laschinger, M., Hogg, N., Pfeffer, K., and Holzmann, B. (2005) Importance of integrin LFA-1 deactivation for the generation of immune responses. J Exp Med 201, 1987-1998

Simeoni, L., Posevitz, V., Kolsch, U., Meinert, I., Bruyns, E., Pfeffer, K., Reinhold, D., and Schraven, B. (2005) The transmembrane adapter protein SIT regulates thymic development and peripheral T-cell functions. Mol Cell Biol 25, 7557-7568

Stevenaert, F., Van Beneden, K., De Colvenaer, V., Franki, A. S., Debacker, V., Boterberg, T., Deforce, D., Pfeffer, K., Plum, J., Elewaut, D., and Leclercq, G. (2005) Ly49 and CD94/NKG2 receptor acquisition by NK cells does not require lymphotoxin-beta receptor expression. Blood 106, 956-962

Wang, J., Anders, R. A., Wang, Y., Turner, J. R., Abraham, C., Pfeffer, K., and Fu, Y. X. (2005) The critical role of LIGHT in promoting intestinal inflammation and Crohn's disease. J Immunol 174, 8173-8182

Wang, Y., Subudhi, S. K., Anders, R. A., Lo, J., Sun, Y., Blink, S., Wang, Y., Wang, J., Liu, X., Mink, K., Degrandi, D., Pfeffer, K., and Fu, Y. X. (2005) The role of herpesvirus entry mediator as a negative regulator of T cell-mediated responses. J Clin Invest 115, 711-717

Wunderlich, F., Dkhil, M. A., Mehnert, L. I., Braun, J. V., El-Khadragy, M., Borsch, E., Hermsen, D., Benten, W. P., Pfeffer, K., Mossmann, H., and Krucken, J. (2005) Testosterone responsiveness of spleen and liver in female lymphotoxin beta receptor-deficient mice resistant to blood-stage malaria. Microbes Infect 7, 399-409

Yu, P., Constien, R., Dear, N., Katan, M., Hanke, P., Bunney, T. D., Kunder, S., Quintanilla-Martinez, L., Huffstadt, U., Schroder, A., Jones, N. P., Peters, T., Fuchs, H., de Angelis, M. H., Nehls, M., Grosse, J., Wabnitz, P., Meyer, T. P., Yasuda, K., Schiemann, M., Schneider-Fresenius, C., Jagla, W., Russ, A., Popp, A., Josephs, M., Marquardt, A., Laufs, J., Schmittwolf, C., Wagner, H., Pfeffer, K., and Mudde, G. C. (2005) Autoimmunity and inflammation due to a gain-of-function mutation in phospholipase C gamma 2 that specifically increases external Ca2+ entry. Immunity 22, 451-465

Bohatschek, M., Kloss, C. U., Hristova, M., Pfeffer, K., and Raivich, G. (2004) Microglial major histocompatibility complex glycoprotein-1 in the axotomized facial motor nucleus: regulation and role of tumor necrosis factor receptors 1 and 2. J Comp Neurol 470, 382-399

Bohatschek, M., Kloss, C. U., Pfeffer, K., Bluethmann, H., and Raivich, G. (2004) B7.2 on activated and phagocytic microglia in the facial axotomy model: regulation by interleukin-1 receptor type 1, tumor necrosis factor receptors 1 and 2 and endotoxin. J Neuroimmunol 156, 132-145

Elvin, S. J., Williamson, E. D., Scott, J. C., Smith, J. N., Perez De Lema, G., Chilla, S., Clapham, P., Pfeffer, K., Schlondorff, D., and Luckow, B. (2004) Evolutionary genetics: Ambiguous role of CCR5 in Y. pestis infection. Nature 430, 417

Luckow, B., Joergensen, J., Chilla, S., Li, J. P., Henger, A., Kiss, E., Wieczorek, G., Roth, L., Hartmann, N., Hoffmann, R., Kretzler, M., Nelson, P. J., Perez de Lema, G., Maier, H., Wurst, W., Balling, R., Pfeffer, K., Grone, H. J., Schlondorff, D., and Zerwes, H. G. (2004) Reduced intragraft mRNA expression of matrix metalloproteinases Mmp3, Mmp12, Mmp13 and Adam8, and diminished transplant arteriosclerosis in Ccr5-deficient mice. Eur J Immunol 34, 2568-2578

Maier, S., Traeger, T., Entleutner, M., Westerholt, A., Kleist, B., Huser, N., Holzmann, B., Stier, A., Pfeffer, K., and Heidecke, C. D. (2004) Cecal ligation and puncture versus colon ascendens stent peritonitis: two distinct animal models for polymicrobial sepsis. Shock 21, 505-511

Radosevic, N., Winterstein, D., Keller, J. R., Neubauer, H., Pfeffer, K., and Linnekin, D. (2004) JAK2 contributes to the intrinsic capacity of primary hematopoietic cells to respond to stem cell factor. Exp Hematol 32, 149-156

Vossenkamper, A., Struck, D., Alvarado-Esquivel, C., Went, T., Takeda, K., Akira, S., Pfeffer, K., Alber, G., Lochner, M., Forster, I., and Liesenfeld, O. (2004) Both IL-12 and IL-18 contribute to small intestinal Th1-type immunopathology following oral infection with Toxoplasma gondii, but IL-12 is dominant over IL-18 in parasite control. Eur J Immunol 34, 3197-3207

Abe, K., Yarovinsky, F. O., Murakami, T., Shakhov, A. N., Tumanov, A. V., Ito, D., Drutskaya, L. N., Pfeffer, K., Kuprash, D. V., Komschlies, K. L., and Nedospasov, S. A. (2003) Distinct contributions of TNF and LT cytokines to the development of dendritic cells in vitro and their recruitment in vivo. Blood 101, 1477-1483

Alvarez-Dolado, M., Pardal, R., Garcia-Verdugo, J. M., Fike, J. R., Lee, H. O., Pfeffer, K., Lois, C., Morrison, S. J., and Alvarez-Buylla, A. (2003) Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes. Nature 425, 968-973

Barthel, M., Hapfelmeier, S., Quintanilla-Martinez, L., Kremer, M., Rohde, M., Hogardt, M., Pfeffer, K., Russmann, H., and Hardt, W. D. (2003) Pretreatment of mice with streptomycin provides a Salmonella enterica serovar Typhimurium colitis model that allows analysis of both pathogen and host. Infect Immun 71, 2839-2858

Boehm, T., Scheu, S., Pfeffer, K., and Bleul, C. C. (2003) Thymic medullary epithelial cell differentiation, thymocyte emigration, and the control of autoimmunity require lympho-epithelial cross talk via LTbetaR. J Exp Med 198, 757-769

Ehlers, S., Holscher, C., Scheu, S., Tertilt, C., Hehlgans, T., Suwinski, J., Endres, R., and Pfeffer, K. (2003) The lymphotoxin beta receptor is critically involved in controlling infections with the intracellular pathogens Mycobacterium tuberculosis and Listeria monocytogenes. J Immunol 170, 5210-5218

Endres, R., Hacker, G., Brosch, I., and Pfeffer, K. (2003) Apparently normal tumor necrosis factor receptor 1 signaling in the absence of the silencer of death domains. Mol Cell Biol 23, 6609-6617

Kather, A., Chantakru, S., He, H., Minhas, K., Foster, R., Markert, U. R., Pfeffer, K., and Croy, B. A. (2003) Neither lymphotoxin alpha nor lymphotoxin beta receptor expression is required for biogenesis of lymphoid aggregates or differentiation of natural killer cells in the pregnant mouse uterus. Immunology 108, 338-345

Klamp, T., Boehm, U., Schenk, D., Pfeffer, K., and Howard, J. C. (2003) A giant GTPase, very large inducible GTPase-1, is inducible by IFNs. J Immunol 171, 1255-1265

Pfeffer, K. (2003) Biological functions of tumor necrosis factor cytokines and their receptors. Cytokine Growth Factor Rev 14, 185-191

Raivich, G., Bohatschek, M., Werner, A., Jones, L. L., Galiano, M., Kloss, C. U., Zhu, X. Z., Pfeffer, K., and Liu, Z. Q. (2003) Lymphocyte infiltration in the injured brain: role of proinflammatory cytokines. J Neurosci Res 72, 726-733

Raupach, B., Kurth, N., Pfeffer, K., and Kaufmann, S. H. (2003) Salmonella typhimurium strains carrying independent mutations display similar virulence phenotypes yet are controlled by distinct host defense mechanisms. J Immunol 170, 6133-6140

Sivakumar, V., Hammond, K. J., Howells, N., Pfeffer, K., and Weih, F. (2003) Differential requirement for Rel/nuclear factor kappa B family members in natural killer T cell development. J Exp Med 197, 1613-1621

Tunaru, S., Kero, J., Schaub, A., Wufka, C., Blaukat, A., Pfeffer, K., and Offermanns, S. (2003) PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect. Nat Med 9, 352-355

Varinou, L., Ramsauer, K., Karaghiosoff, M., Kolbe, T., Pfeffer, K., Muller, M., and Decker, T. (2003) Phosphorylation of the Stat1 transactivation domain is required for full-fledged IFN-gamma-dependent innate immunity. Immunity 19, 793-802

Hehlgans, T., Stoelcker, B., Stopfer, P., Muller, P., Cernaianu, G., Guba, M., Steinbauer, M., Nedospasov, S. A., Pfeffer, K., and Mannel, D. N. (2002) Lymphotoxin-beta receptor immune interaction promotes tumor growth by inducing angiogenesis. Cancer Res 62, 4034-4040

Kuprash, D. V., Alimzhanov, M. B., Tumanov, A. V., Grivennikov, S. I., Shakhov, A. N., Drutskaya, L. N., Marino, M. W., Turetskaya, R. L., Anderson, A. O., Rajewsky, K., Pfeffer, K., and Nedospasov, S. A. (2002) Redundancy in tumor necrosis factor (TNF) and lymphotoxin (LT) signaling in vivo: mice with inactivation of the entire TNF/LT locus versus single-knockout mice. Mol Cell Biol 22, 8626-8634

Paxian, S., Merkle, H., Riemann, M., Wilda, M., Adler, G., Hameister, H., Liptay, S., Pfeffer, K., and Schmid, R. M. (2002) Abnormal organogenesis of Peyer's patches in mice deficient for NF-kappaB1, NF-kappaB2, and Bcl-3. Gastroenterology 122, 1853-1868

Prinz, M., Montrasio, F., Klein, M. A., Schwarz, P., Priller, J., Odermatt, B., Pfeffer, K., and Aguzzi, A. (2002) Lymph nodal prion replication and neuroinvasion in mice devoid of follicular dendritic cells. Proc Natl Acad Sci U S A 99, 919-924

Reiter, R., and Pfeffer, K. (2002) Impaired germinal centre formation and humoral immune response in the absence of CD28 and interleukin-4. Immunology 106, 222-228

Schaller, E., Macfarlane, A. J., Rupec, R. A., Gordon, S., McKnight, A. J., and Pfeffer, K. (2002) Inactivation of the F4/80 glycoprotein in the mouse germ line. Mol Cell Biol 22, 8035-8043

Scheu, S., Alferink, J., Potzel, T., Barchet, W., Kalinke, U., and Pfeffer, K. (2002) Targeted disruption of LIGHT causes defects in costimulatory T cell activation and reveals cooperation with lymphotoxin beta in mesenteric lymph node genesis. J Exp Med 195, 1613-1624

Shillingford, J. M., Miyoshi, K., Robinson, G. W., Grimm, S. L., Rosen, J. M., Neubauer, H., Pfeffer, K., and Hennighausen, L. (2002) Jak2 is an essential tyrosine kinase involved in pregnancy-mediated development of mammary secretory epithelium. Mol Endocrinol 16, 563-570

Thalmaier, U., Lehn, N., Pfeffer, K., Stolte, M., Vieth, M., and Schneider-Brachert, W. (2002) Role of tumor necrosis factor alpha in Helicobacter pylori gastritis in tumor necrosis factor receptor 1-deficient mice. Infect Immun 70, 3149-3155

Wang, J., Foster, A., Chin, R., Yu, P., Sun, Y., Wang, Y., Pfeffer, K., and Fu, Y. X. (2002) The complementation of lymphotoxin deficiency with LIGHT, a newly discovered TNF family member, for the restoration of secondary lymphoid structure and function. Eur J Immunol 32, 1969-1979

Ghaffari, S., Kitidis, C., Fleming, M. D., Neubauer, H., Pfeffer, K., and Lodish, H. F. (2001) Erythropoiesis in the absence of janus-kinase 2: BCR-ABL induces red cell formation in JAK2(-/-) hematopoietic progenitors. Blood 98, 2948-2957

Girkontaite, I., Missy, K., Sakk, V., Harenberg, A., Tedford, K., Potzel, T., Pfeffer, K., and Fischer, K. D. (2001) Lsc is required for marginal zone B cells, regulation of lymphocyte motility and immune responses. Nat Immunol 2, 855-862

Lengeling, A., Pfeffer, K., and Balling, R. (2001) The battle of two genomes: genetics of bacterial host/pathogen interactions in mice. Mamm Genome 12, 261-271

Maier, S., Tertilt, C., Chambron, N., Gerauer, K., Huser, N., Heidecke, C. D., and Pfeffer, K. (2001) Inhibition of natural killer cells results in acceptance of cardiac allografts in CD28-/- mice. Nat Med 7, 557-562

Plitz, T., and Pfeffer, K. (2001) Intact lysosome transport and phagosome function despite kinectin deficiency. Mol Cell Biol 21, 6044-6055

Schaub, A., Futterer, A., and Pfeffer, K. (2001) PUMA-G, an IFN-gamma-inducible gene in macrophages is a novel member of the seven transmembrane spanning receptor superfamily. Eur J Immunol 31, 3714-3725

Wu, Q., Sun, Y., Wang, J., Lin, X., Wang, Y., Pegg, L. E., Futterer, A., Pfeffer, K., and Fu, Y. X. (2001) Signal via lymphotoxin-beta R on bone marrow stromal cells is required for an early checkpoint of NK cell development. J Immunol 166, 1684-1689

Burdon, D., Tiedje, T., Pfeffer, K., Vollmer, E., and Zabel, P. (2000) The role of tumor necrosis factor in the development of multiple organ failure in a murine model. Crit Care Med 28, 1962-1967

Ehlers, S., Kutsch, S., Ehlers, E. M., Benini, J., and Pfeffer, K. (2000) Lethal granuloma disintegration in mycobacteria-infected TNFRp55-/- mice is dependent on T cells and IL-12. J Immunol 165, 483-492

Flaswinkel, H., Alessandrini, F., Rathkolb, B., Decker, T., Kremmer, E., Servatius, A., Jakob, T., Soewarto, D., Marschall, S., Fella, C., Behrendt, H., Ring, J., Wolf, E., Balling, R., Hrabe de Angelis, M., and Pfeffer, K. (2000) Identification of immunological relevant phenotypes in ENU mutagenized mice. Mamm Genome 11, 526-527

Greiner, A., Muller, K. B., Hess, J., Pfeffer, K., Muller-Hermelink, H. K., and Wirth, T. (2000) Up-regulation of BOB.1/OBF.1 expression in normal germinal center B cells and germinal center-derived lymphomas. Am J Pathol 156, 501-507

Hochholzer, P., Lipford, G. B., Wagner, H., Pfeffer, K., and Heeg, K. (2000) Role of interleukin-18 (IL-18) during lethal shock: decreased lipopolysaccharide sensitivity but normal superantigen reaction in IL-18-deficient mice. Infect Immun 68, 3502-3508

Hrabe de Angelis, M. H., Flaswinkel, H., Fuchs, H., Rathkolb, B., Soewarto, D., Marschall, S., Heffner, S., Pargent, W., Wuensch, K., Jung, M., Reis, A., Richter, T., Alessandrini, F., Jakob, T., Fuchs, E., Kolb, H., Kremmer, E., Schaeble, K., Rollinski, B., Roscher, A., Peters, C., Meitinger, T., Strom, T., Steckler, T., Holsboer, F., Klopstock, T., Gekeler, F., Schindewolf, C., Jung, T., Avraham, K., Behrendt, H., Ring, J., Zimmer, A., Schughart, K., Pfeffer, K., Wolf, E., and Balling, R. (2000) Genome-wide, large-scale production of mutant mice by ENU mutagenesis. Nat Genet 25, 444-447

Karaghiosoff, M., Neubauer, H., Lassnig, C., Kovarik, P., Schindler, H., Pircher, H., McCoy, B., Bogdan, C., Decker, T., Brem, G., Pfeffer, K., and Muller, M. (2000) Partial impairment of cytokine responses in Tyk2-deficient mice. Immunity 13, 549-560

Maier, S., Emmanuilidis, K., Entleutner, M., Zantl, N., Werner, M., Pfeffer, K., and Heidecke, C. D. (2000) Massive chemokine transcription in acute renal failure due to polymicrobial sepsis. Shock 14, 187-192

Pfeffer, K. (2000) Morphogenic and host protective functions executed by tumor necrosis factor receptors, lymphotoxin receptors and their ligands. Eur Cytokine Netw 11, 514

Souto, J. T., Figueiredo, F., Furlanetto, A., Pfeffer, K., Rossi, M. A., and Silva, J. S. (2000) Interferon-gamma and tumor necrosis factor-alpha determine resistance to Paracoccidioides brasiliensis infection in mice. Am J Pathol 156, 1811-1820

Westerholt, S., Hartung, T., Tollens, M., Gustrau, A., Oberhoffer, M., Karch, H., Klare, B., Pfeffer, K., Emmrich, P., and Oberhoffer, R. (2000) Inflammatory and immunological parameters in children with haemolytic uremic syndrome (HUS) and gastroenteritis-pathophysiological and diagnostic clues. Cytokine 12, 822-827

Barthlen, W., Zantl, N., Pfeffer, K., Heidecke, C. D., Holzmann, B., and Stadler, J. (1999) Impact of experimental peritonitis on bone marrow cell function. Surgery 126, 41-47

Carson, W. E., Yu, H., Dierksheide, J., Pfeffer, K., Bouchard, P., Clark, R., Durbin, J., Baldwin, A. S., Peschon, J., Johnson, P. R., Ku, G., Baumann, H., and Caligiuri, M. A. (1999) A fatal cytokine-induced systemic inflammatory response reveals a critical role for NK cells. J Immunol 162, 4943-4951

Ehlers, S., Benini, J., Kutsch, S., Endres, R., Rietschel, E. T., and Pfeffer, K. (1999) Fatal granuloma necrosis without exacerbated mycobacterial growth in tumor necrosis factor receptor p55 gene-deficient mice intravenously infected with Mycobacterium avium. Infect Immun 67, 3571-3579

Endres, R., Alimzhanov, M. B., Plitz, T., Futterer, A., Kosco-Vilbois, M. H., Nedospasov, S. A., Rajewsky, K., and Pfeffer, K. (1999) Mature follicular dendritic cell networks depend on expression of lymphotoxin beta receptor by radioresistant stromal cells and of lymphotoxin beta and tumor necrosis factor by B cells. J Exp Med 189, 159-168

Kreder, D., Krut, O., Adam-Klages, S., Wiegmann, K., Scherer, G., Plitz, T., Jensen, J. M., Proksch, E., Steinmann, J., Pfeffer, K., and Kronke, M. (1999) Impaired neutral sphingomyelinase activation and cutaneous barrier repair in FAN-deficient mice. EMBO J 18, 2472-2479

Kuprash, D. V., Alimzhanov, M. B., Tumanov, A. V., Anderson, A. O., Pfeffer, K., and Nedospasov, S. A. (1999) TNF and lymphotoxin beta cooperate in the maintenance of secondary lymphoid tissue microarchitecture but not in the development of lymph nodes. J Immunol 163, 6575-6580

Neumann, B., Zantl, N., Veihelmann, A., Emmanuilidis, K., Pfeffer, K., Heidecke, C. D., and Holzmann, B. (1999) Mechanisms of acute inflammatory lung injury induced by abdominal sepsis. Int Immunol 11, 217-227

Plitz, T., Huffstadt, U., Endres, R., Schaller, E., Mak, T. W., Wagner, H., and Pfeffer, K. (1999) The resistance against Listeria monocytogenes and the formation of germinal centers depend on a functional death domain of the 55 kDa tumor necrosis factor receptor. Eur J Immunol 29, 581-591

Boehm, U., Guethlein, L., Klamp, T., Ozbek, K., Schaub, A., Futterer, A., Pfeffer, K., and Howard, J. C. (1998) Two families of GTPases dominate the complex cellular response to IFN-gamma. J Immunol 161, 6715-6723

Futterer, A., Mink, K., Luz, A., Kosco-Vilbois, M. H., and Pfeffer, K. (1998) The lymphotoxin beta receptor controls organogenesis and affinity maturation in peripheral lymphoid tissues. Immunity 9, 59-70

Gerauer, K., Maier, S., Emmanuilidis, K., Chambron, N., Zantl, N., Pfeffer, K., and Heidecke, C. D. (1998) Long-term cardiac allograft survival in mice treated with malononitrilamide 715. Transplant Proc 30, 4205-4206

Neubauer, H., Cumano, A., Muller, M., Wu, H., Huffstadt, U., and Pfeffer, K. (1998) Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis. Cell 93, 397-409

Schepp, W., Dehne, K., Herrmuth, H., Pfeffer, K., and Prinz, C. (1998) Identification and functional importance of IL-1 receptors on rat parietal cells. Am J Physiol 275, G1094-1105

Schuh, K., Kneitz, B., Heyer, J., Bommhardt, U., Jankevics, E., Berberich-Siebelt, F., Pfeffer, K., Muller-Hermelink, H. K., Schimpl, A., and Serfling, E. (1998) Retarded thymic involution and massive germinal center formation in NF-ATp-deficient mice. Eur J Immunol 28, 2456-2466

Wajant, H., Pfeffer, K., Pfizenmaier, K., and Scheurich, P. (1998) Tumor necrosis factors in 1998. Cytokine Growth Factor Rev 9, 297-302

Zantl, N., Uebe, A., Neumann, B., Wagner, H., Siewert, J. R., Holzmann, B., Heidecke, C. D., and Pfeffer, K. (1998) Essential role of gamma interferon in survival of colon ascendens stent peritonitis, a novel murine model of abdominal sepsis. Infect Immun 66, 2300-2309

Alimzhanov, M. B., Kuprash, D. V., Kosco-Vilbois, M. H., Luz, A., Turetskaya, R. L., Tarakhovsky, A., Rajewsky, K., Nedospasov, S. A., and Pfeffer, K. (1997) Abnormal development of secondary lymphoid tissues in lymphotoxin beta-deficient mice. Proc Natl Acad Sci U S A 94, 9302-9307

Bachmaier, K., Pummerer, C., Kozieradzki, I., Pfeffer, K., Mak, T. W., Neu, N., and Penninger, J. M. (1997) Low-molecular-weight tumor necrosis factor receptor p55 controls induction of autoimmune heart disease. Circulation 95, 655-661

Endres, R., Luz, A., Schulze, H., Neubauer, H., Futterer, A., Holland, S. M., Wagner, H., and Pfeffer, K. (1997) Listeriosis in p47(phox-/-) and TRp55-/- mice: protection despite absence of ROI and susceptibility despite presence of RNI. Immunity 7, 419-432

Hoidal, J. R., Xu, P., Huecksteadt, T., Sanders, K. A., and Pfeffer, K. (1997) Transcriptional regulation of human xanthine dehydrogenase/xanthine oxidase. Biochem Soc Trans 25, 796-799

Lang, R., Pfeffer, K., Wagner, H., and Heeg, K. (1997) A rapid method for semiquantitative analysis of the human V beta-repertoire using TaqManR PCR. J Immunol Methods 203, 181-192

Speiser, D. E., Bachmann, M. F., Frick, T. W., McKall-Faienza, K., Griffiths, E., Pfeffer, K., Mak, T. W., and Ohashi, P. S. (1997) TNF receptor p55 controls early acute graft-versus-host disease. J Immunol 158, 5185-5190

Neumann, B., Luz, A., Pfeffer, K., and Holzmann, B. (1996) Defective Peyer's patch organogenesis in mice lacking the 55-kD receptor for tumor necrosis factor. J Exp Med 184, 259-264

Neumann, B., Machleidt, T., Lifka, A., Pfeffer, K., Vestweber, D., Mak, T. W., Holzmann, B., and Kronke, M. (1996) Crucial role of 55-kilodalton TNF receptor in TNF-induced adhesion molecule expression and leukocyte organ infiltration. J Immunol 156, 1587-1593

Speiser, D. E., Sebzda, E., Ohteki, T., Bachmann, M. F., Pfeffer, K., Mak, T. W., and Ohashi, P. S. (1996) Tumor necrosis factor receptor p55 mediates deletion of peripheral cytotoxic T lymphocytes in vivo. Eur J Immunol 26, 3055-3060

Vieira, L. Q., Goldschmidt, M., Nashleanas, M., Pfeffer, K., Mak, T., and Scott, P. (1996) Mice lacking the TNF receptor p55 fail to resolve lesions caused by infection with Leishmania major, but control parasite replication. J Immunol 157, 827-835

Boucher, L. M., Wiegmann, K., Futterer, A., Pfeffer, K., Machleidt, T., Schutze, S., Mak, T. W., and Kronke, M. (1995) CD28 signals through acidic sphingomyelinase. J Exp Med 181, 2059-2068

Flynn, J. L., Goldstein, M. M., Chan, J., Triebold, K. J., Pfeffer, K., Lowenstein, C. J., Schreiber, R., Mak, T. W., and Bloom, B. R. (1995) Tumor necrosis factor-alpha is required in the protective immune response against Mycobacterium tuberculosis in mice. Immunity 2, 561-572

Mittrucker, H. W., Pfeffer, K., Schmits, R., and Mak, T. W. (1995) T-lymphocyte development and function in gene-targeted mutant mice. Immunol Rev 148, 115-150

Pfeffer, K., and Mak, T. W. (1994) Lymphocyte ontogeny and activation in gene targeted mutant mice. Annu Rev Immunol 12, 367-411

Pluschke, G., Taube, H., Krawinkel, U., Pfeffer, K., Wagner, H., Classen, M., and Deusch, K. (1994) Oligoclonality and skewed T cell receptor V beta gene segment expression in in vivo activated human intestinal intraepithelial T lymphocytes. Immunobiology 192, 77-93

Kishihara, K., Penninger, J., Wallace, V. A., Kundig, T. M., Kawai, K., Wakeham, A., Timms, E., Pfeffer, K., Ohashi, P. S., Thomas, M. L., and et al. (1993) Normal B lymphocyte development but impaired T cell maturation in CD45-exon6 protein tyrosine phosphatase-deficient mice. Cell 74, 143-156

Matsuyama, T., Kimura, T., Kitagawa, M., Pfeffer, K., Kawakami, T., Watanabe, N., Kundig, T. M., Amakawa, R., Kishihara, K., Wakeham, A., and et al. (1993) Targeted disruption of IRF-1 or IRF-2 results in abnormal type I IFN gene induction and aberrant lymphocyte development. Cell 75, 83-97

Pfeffer, K., Matsuyama, T., Kundig, T. M., Wakeham, A., Kishihara, K., Shahinian, A., Wiegmann, K., Ohashi, P. S., Kronke, M., and Mak, T. W. (1993) Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection. Cell 73, 457-467

Pfeffer, K. D., Huecksteadt, T. P., and Hoidal, J. R. (1993) Expression and regulation of tumor necrosis factor in macrophages from cystic fibrosis patients. Am J Respir Cell Mol Biol 9, 511-519

Shahinian, A., Pfeffer, K., Lee, K. P., Kundig, T. M., Kishihara, K., Wakeham, A., Kawai, K., Ohashi, P. S., Thompson, C. B., and Mak, T. W. (1993) Differential T cell costimulatory requirements in CD28-deficient mice. Science 261, 609-612

Hacker, G., Kromer, S., Falk, M., Heeg, K., Wagner, H., and Pfeffer, K. (1992) V delta 1+ subset of human gamma delta T cells responds to ligands expressed by EBV-infected Burkitt lymphoma cells and transformed B lymphocytes. J Immunol 149, 3984-3989

Hacker, G., Kromer, S., Heeg, K., Ivanyi, J., Wagner, H., and Pfeffer, K. (1992) Opportunist mycobacteria express ligands that stimulate production of human V gamma 9V delta 2 T lymphocytes. Infect Immun 60, 2753-2757

Pfeffer, K., Schoel, B., Plesnila, N., Lipford, G. B., Kromer, S., Deusch, K., and Wagner, H. (1992) A lectin-binding, protease-resistant mycobacterial ligand specifically activates V gamma 9+ human gamma delta T cells. J Immunol 148, 575-583

Deusch, K., Luling, F., Reich, K., Classen, M., Wagner, H., and Pfeffer, K. (1991) A major fraction of human intraepithelial lymphocytes simultaneously expresses the gamma/delta T cell receptor, the CD8 accessory molecule and preferentially uses the V delta 1 gene segment. Eur J Immunol 21, 1053-1059

Deusch, K., Pfeffer, K., Reich, K., Gstettenbauer, M., Daum, S., Luling, F., and Classen, M. (1991) Phenotypic and functional characterization of human TCR gamma delta+ intestinal intraepithelial lymphocytes. Curr Top Microbiol Immunol 173, 279-283

Goerlich, R., Hacker, G., Pfeffer, K., Heeg, K., and Wagner, H. (1991) Plasmodium falciparum merozoites primarily stimulate the V gamma 9 subset of human gamma/delta T cells. Eur J Immunol 21, 2613-2616

Pfeffer, K., Schoel, B., Gulle, H., Kaufmann, S. H., and Wagner, H. (1991) Human gamma/delta T cells responding to mycobacteria. Behring Inst Mitt, 36-42

Pfeffer, K., Schoel, B., Gulle, H., Moll, H., Kromer, S., Kaufmann, S. H., and Wagner, H. (1991) Analysis of primary T cell responses to intact and fractionated microbial pathogens. Curr Top Microbiol Immunol 173, 173-178

Munk, M. E., Gatrill, A. J., Schoel, B., Gulle, H., Pfeffer, K., Wagner, H., and Kaufmann, S. H. (1990) Immunity to mycobacteria: possible role of alpha/beta and gamma/delta T lymphocytes. APMIS 98, 669-673

Pfeffer, K., Schoel, B., Gulle, H., Kaufmann, S. H., and Wagner, H. (1990) Primary responses of human T cells to mycobacteria: a frequent set of gamma/delta T cells are stimulated by protease-resistant ligands. Eur J Immunol 20, 1175-1179

Pfeffer, K., Heeg, K., Bubeck, R., Conradt, P., and Wagner, H. (1989) Adoptive transfer of human peripheral blood lymphocytes (PBL) in scid mice. Curr Top Microbiol Immunol 152, 211-217

Pfeffer, K., Nerl, C., and Kabelitz, D. (1987) B cell maturation in chronic lymphocytic leukemia. II. Clonal heterogeneity in the response to various B cell activators and recombinant cytokines (rIFN-gamma, rIFN-alpha, rIL2). Immunobiology 175, 172-182

Kabelitz, D., Pfeffer, K., von Steldern, D., Bartmann, P., Brudler, O., Nerl, C., and Wagner, H. (1985) In vitro maturation of B cells in chronic lymphocytic leukemia. I. Synergistic action of phorbol ester and interleukin 2 in the induction of Tac antigen expression and interleukin 2 responsiveness in leukemic B cells. J Immunol 135, 2876-2881


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