Publikationen K. Stühler

Publications 2019

Unconventional protein secretion: The hidden pathways.
Stühler K, Schipper K, Poschmann G. Biochim Biophys Acta Proteins Proteom. 2019 Dec;1867(12):140272. doi: 10.1016/j.bbapap.2019.140272. Epub 2019 Sep 6. No abstract available PMID:31499220

Shaping the lipid composition of bacterial membranes for membrane protein production.
Kanonenberg K, Royes J, Kedrov A, Poschmann G, Angius F, Solgadi A, Spitz O, Kleinschrodt D, Stühler K, Miroux B, Schmitt L.; Microb Cell Fact. 2019 Aug 10;18(1):131. doi: 10.1186/s12934-019-1182-1. PMID:31400768

Pitfalls and opportunities in the characterization of unconventionally secreted proteins by secretome analysis.
Schira-Heinen J, Grube L, Waldera-Lupa DM, Baberg F, Langini M, Etemad-Parishanzadeh O, Poschmann G, Stühler K. Biochim Biophys Acta Proteins Proteom. 2019 Dec;1867(12):140237. doi: 10.1016/j.bbapap.2019.06.004. Epub 2019 Jun 12. Review. PMID:31202002

Adipokinome Signatures in Obese Mouse Models Reflect Adipose Tissue Health and Are Associated with Serum Lipid Composition.
Knebel B, Fahlbusch P, Poschmann G, Dille M, Wahlers N, Stühler K, Hartwig S, Lehr S, Schiller M, Jacob S, Kettel U, Müller-Wieland D, Kotzka J. Int J Mol Sci. 2019 May 24;20(10). pii: E2559. doi: 10.3390/ijms20102559. PMID: 31137678

HDAC5 Expression in Urothelial Carcinoma Cell Lines Inhibits Long-Term Proliferation but Can Promote Epithelial-to-Mesenchymal Transition.
Jaguva Vasudevan AA, Hoffmann MJ, Beck MLC, Poschmann G, Petzsch P, Wiek C, Stühler K, Köhrer K, Schulz WA, Niegisch G. Int J Mol Sci. 2019 Apr 30;20(9). pii: E2135. doi: 10.3390/ijms20092135. PMID: 31052182

Control of Drosophila Growth and Survival by the Lipid Droplet-Associated Protein CG9186/Sturkopf.
Werthebach M, Stewart FA, Gahlen A, Mettler-Altmann T, Akhtar I, Maas-Enriquez K, Droste A, Eichmann TO, Poschmann G, Stühler K, Beller M. Cell Rep. 2019 Mar 26;26(13):3726-3740.e7. doi: 10.1016/j.celrep.2019.02.110. PMID: 30917324

Native aortic valve derived extracellular matrix hydrogel for three dimensional culture analyses with improved biomimetic properties.
Nehrenheim L, Raschke S, Stefanski A, Barth M, Isabel Selig J, Barbian A, Fernández-Colino A, Stühler K, Mela P, Albert A, Lichtenberg A, Akhyari P. Biomed Mater. 2019 Apr 5;14(3):035014. doi: 10.1088/1748-605X/ab0791. PMID:30769335

Secretome analysis of human bone marrow derived mesenchymal stromal cells.
Baberg F, Geyh S, Waldera-Lupa D, Stefanski A, Zilkens C, Haas R, Schroeder T, Stühler K. Biochim Biophys Acta Proteins Proteom. 2019 Apr;1867(4):434-441. doi: 10.1016/j.bbapap.2019.01.013. Epub 2019 Feb 1. PMID: 30716505

Quantitative insights into the cyanobacterial cell economy.
Zavřel T, Faizi M, Loureiro C, Poschmann G, Stühler K, Sinetova M, Zorina A, Steuer R, Červený J. Elife. 2019 Feb 4;8. pii: e42508. doi: 10.7554/eLife.42508. PMID: 30714903

A Proteome Approach Reveals Differences between Fertile Women and Patients with Repeated Implantation Failure on Endometrial Level⁻Does hCG Render the Endometrium of RIF Patients?
Bielfeld AP, Pour SJ, Poschmann G, Stühler K, Krüssel JS, Baston-Büst DM. Int J Mol Sci. 2019 Jan 19;20(2). pii: E425. doi: 10.3390/ijms20020425. PMID: 30669470

Secretome analysis of nerve repair mediating Schwann cells reveals Smad-dependent trophism.
Schira J, Heinen A, Poschmann G, Ziegler B, Hartung HP, Stühler K, Küry P. FASEB J. 2019 Apr;33(4):4703-4715. doi: 10.1096/fj.201801799R. Epub 2018 Dec 28. PMID: 30592632

Predicting eukaryotic protein secretion without signals.
Nielsen H, Petsalaki EI, Zhao L, Stühler K. Biochim Biophys Acta Proteins Proteom. 2019 Dec;1867(12):140174. doi: 10.1016/j.bbapap.2018.11.011. Epub 2018 Dec 4. Review. PMID: 30529297


Publications 2018

A proteomics approach for the identification of species-specific immunogenic proteins in the Mycobacterium abscessus complex.
Steindor M, Nkwouano V, Stefanski A, Stuehler K, Ioerger TR, Bogumil D, Jacobsen M, Mackenzie CR, Kalscheuer R. Microbes Infect. 2019 Apr - May;21(3-4):154-162. doi: 10.1016/j.micinf.2018.10.006. Epub 2018 Nov 13. PMID: 30445130

Correction: SIRT4 interacts with OPA1 and regulates mitochondrial quality control and mitophagy.
Lang A, Anand R, Altinoluk-Hambüchen S, Ezzahoini H, Stefanski A, Iram A, Bergmann L, Urbach J, Böhler P, Hänsel J, Franke M, Stühler K, Krutmann J, Scheller J, Stork B, Reichert AS, Piekorz RP. Aging (Albany NY). 2018 Sep 28;10(9):2536c. doi: 10.18632/aging.101570. No abstract available. PMID: 30300139

Cholestasis induced liver pathology results in dysfunctional immune responses after arenavirus infection.
Lang E, Pozdeev VI, Shinde PV, Xu HC, Sundaram B, Zhuang Y, Poschmann G, Huang J, Stühler K, Pandyra AA, Keitel V, Häussinger D, Lang KS, Lang PA. Sci Rep. 2018 Aug 15;8(1):12179. doi: 10.1038/s41598-018-30627-y. PMID: 30111770

Laminin-521 promotes quiescence in isolated stellate cells from rat liver.
Rohn F, Kordes C, Castoldi M, Götze S, Poschmann G, Stühler K, Herebian D, Benk AS, Geiger F, Zhang T, Spatz JP, Häussinger D. Biomaterials. 2018 Oct;180:36-51. doi: 10.1016/j.biomaterials.2018.07.008. Epub 2018 Jul 7. PMID: 30014965

Corrigendum to 'Impaired Ca2+ cycling of nonischemic myocytes contributes to sarcomere dysfunction early after myocardial infarction' [J. Mol. Cell. Cardiol. 119 (2018) 28-39].
Kronenbitter A, Funk F, Hackert K, Gorreßen S, Glaser D, Boknik P, Poschmann G, Stühler K, Isić M, Krüger M, Schmitt JP. J Mol Cell Cardiol. 2018 Aug;121:304. doi: 10.1016/j.yjmcc.2018.06.004. Epub 2018 Jun 12. No abstract available. PMID: 29907408

Impaired Ca2+ cycling of nonischemic myocytes contributes to sarcomere dysfunction early after myocardial infarction.
Kronenbitter A, Funk F, Hackert K, Gorreßen S, Glaser D, Boknik P, Poschmann G, Stühler K, Isić M, Krüger M, Schmitt JP. J Mol Cell Cardiol. 2018 Jun;119:28-39. doi: 10.1016/j.yjmcc.2018.04.004. Epub 2018 Apr 16. Erratum in: J Mol Cell Cardiol. 2018 Aug;121:304. PMID: 29674140

Targeting liver sinusoidal endothelial cells with miR-20a-loaded nanoparticles reduces murine colon cancer metastasis to the liver.
Marquez J, Fernandez-Piñeiro I, Araúzo-Bravo MJ, Poschmann G, Stühler K, Khatib AM, Sanchez A, Unda F, Ibarretxe G, Bernales I, Badiola I. Int J Cancer. 2018 Aug 1;143(3):709-719. doi: 10.1002/ijc.31343. Epub 2018 Mar 15. PMID: 29492958

Mining the Secretome of C2C12 Muscle Cells: Data Dependent Experimental Approach To Analyze Protein Secretion Using Label-Free Quantification and Peptide Based Analysis.
Grube L, Dellen R, Kruse F, Schwender H, Stühler K, Poschmann G. J Proteome Res. 2018 Feb 2;17(2):879-890. doi: 10.1021/acs.jproteome.7b00684. Epub 2018 Jan 24. PMID: 29322779


Publications 2017

Proteomic changes in cerebrospinal fluid from primary central nervous system lymphoma patients are associated with protein ectodomain shedding.
Waldera-Lupa DM, Etemad-Parishanzadeh O, Brocksieper M, Kirchgaessler N, Seidel S, Kowalski T, Montesinos-Rongen M, Deckert M, Schlegel U, Stühler K. Oncotarget. 2017 Nov 24;8(66):110118-110132. doi: 10.18632/oncotarget.22654. eCollection 2017 Dec 15. PMID: 29299134

Genetic profiling and surface proteome analysis of human atrial stromal cells and rat ventricular epicardium-derived cells reveals novel insights into their cardiogenic potential.
Temme S, Friebe D, Schmidt T, Poschmann G, Hesse J, Steckel B, Stühler K, Kunz M, Dandekar T, Ding Z, Akhyari P, Lichtenberg A, Schrader J. Stem Cell Res. 2017 Dec;25:183-190. doi: 10.1016/j.scr.2017.11.006. Epub 2017 Nov 7. PMID: 29156374

SIRT4 interacts with OPA1 and regulates mitochondrial quality control and mitophagy.
Lang A, Anand R, Altinoluk-Hambüchen S, Ezzahoini H, Stefanski A, Iram A, Bergmann L, Urbach J, Böhler P, Hänsel J, Franke M, Stühler K, Krutmann J, Scheller J, Stork B, Reichert AS, Piekorz RP. Aging (Albany NY). 2017 Oct 29;9(10):2163-2189. doi: 10.18632/aging.101307. Erratum in: Aging (Albany NY). 2018 Sep 28;10(9):2536c. PMID: 29081403

Evaluation of Decellularized Porcine Jejunum as a Matrix for Lacrimal Gland Reconstruction In Vitro for Treatment of Dry Eye Syndrome.
Massie I, Spaniol K, Barbian A, Poschmann G, Stühler K, Geerling G, Metzger M, Mertsch S, Schrader S. Invest Ophthalmol Vis Sci. 2017 Oct 1;58(12):5564-5574. doi: 10.1167/iovs.16-20759. PMID: 29079859

Progesterone receptor membrane component 1 is phosphorylated upon progestin treatment in breast cancer cells.
Willibald M, Bayer G, Stahlhut V, Poschmann G, Stühler K, Gierke B, Pawlak M, Seeger H, Mueck AO, Niederacher D, Fehm T, Neubauer H. Oncotarget. 2017 Aug 2;8(42):72480-72493. doi: 10.18632/oncotarget.19819. eCollection 2017 Sep 22. PMID: 29069804

Massive Protein Import into the Early-Evolutionary-Stage Photosynthetic Organelle of the Amoeba Paulinella chromatophora.
Singer A, Poschmann G, Mühlich C, Valadez-Cano C, Hänsch S, Hüren V, Rensing SA, Stühler K, Nowack ECM. Curr Biol. 2017 Sep 25;27(18):2763-2773.e5. doi: 10.1016/j.cub.2017.08.010. Epub 2017 Sep 7. PMID: 28889978

Novel Insights into the Adipokinome of Obese and Obese/Diabetic Mouse Models.
Knebel B, Goeddeke S, Poschmann G, Markgraf DF, Jacob S, Nitzgen U, Passlack W, Preuss C, Dicken HD, Stühler K, Hartwig S, Lehr S, Kotzka J. Int J Mol Sci. 2017 Sep 8;18(9). pii: E1928. doi: 10.3390/ijms18091928. PMID: 28885548

Succession of splicing regulatory elements determines cryptic 5΄ss functionality.
Brillen AL, Schöneweis K, Walotka L, Hartmann L, Müller L, Ptok J, Kaisers W, Poschmann G, Stühler K, Buratti E, Theiss S, Schaal H. Nucleic Acids Res. 2017 Apr 20;45(7):4202-4216. doi: 10.1093/nar/gkw1317. PMID: 28039323


Publications 2016

A Luciferase-fragment Complementation Assay to Detect Lipid Droplet-associated Protein-Protein Interactions.
Kolkhof P, Werthebach M, van de Venn A, Poschmann G, Chen L, Welte M, Stühler K, Beller M. Mol Cell Proteomics. 2017 Mar;16(3):329-345. doi: 10.1074/mcp.M116.061499. Epub 2016 Dec 12. PMID: 27956707

Glyoxalase 1-knockdown in human aortic endothelial cells - effect on the proteome and endothelial function estimates.
Stratmann B, Engelbrecht B, Espelage BC, Klusmeier N, Tiemann J, Gawlowski T, Mattern Y, Eisenacher M, Meyer HE, Rabbani N, Thornalley PJ, Tschoepe D, Poschmann G, Stühler K. Sci Rep. 2016 Nov 29;6:37737. doi: 10.1038/srep37737. PMID: 27898103

Surveying the Oligomeric State of Arabidopsis thaliana Chloroplasts.
Lundquist PK, Mantegazza O, Stefanski A, Stühler K, Weber APM. Mol Plant. 2017 Jan 9;10(1):197-211. doi: 10.1016/j.molp.2016.10.011. Epub 2016 Oct 26. PMID: 27794502

Misassembly of full-length Disrupted-in-Schizophrenia 1 protein is linked to altered dopamine homeostasis and behavioral deficits.
Trossbach SV, Bader V, Hecher L, Pum ME, Masoud ST, Prikulis I, Schäble S, de Souza Silva MA, Su P, Boulat B, Chwiesko C, Poschmann G, Stühler K, Lohr KM, Stout KA, Oskamp A, Godsave SF, Müller-Schiffmann A, Bilzer T, Steiner H, Peters PJ, Bauer A, Sauvage M, Ramsey AJ, Miller GW, Liu F, Seeman P, Brandon NJ, Huston JP, Korth C. Mol Psychiatry. 2016 Nov;21(11):1561-1572. doi: 10.1038/mp.2015.194. Epub 2016 Jan 12. PMID: 26754951

The Cytoskeleton of Parabasalian Parasites Comprises Proteins that Share Properties Common to Intermediate Filament Proteins.
Preisner H, Karin EL, Poschmann G, Stühler K, Pupko T, Gould SB. Protist. 2016 Dec;167(6):526-543. doi: 10.1016/j.protis.2016.09.001. Epub 2016 Sep 16. PMID: 27744090

Evaluation of the biomarker candidate MFAP4 for non-invasive assessment of hepatic fibrosis in hepatitis C patients.
Bracht T, Mölleken C, Ahrens M, Poschmann G, Schlosser A, Eisenacher M, Stühler K, Meyer HE, Schmiegel WH, Holmskov U, Sorensen GL, Sitek B. J Transl Med. 2016 Jul 4;14(1):201. doi: 10.1186/s12967-016-0952-3. PMID: 27378383

Interdomain regulation of the ATPase activity of the ABC transporter haemolysin B from Escherichia coli.
Reimann S, Poschmann G, Kanonenberg K, Stühler K, Smits SH, Schmitt L. Biochem J. 2016 Aug 15;473(16):2471-83. doi: 10.1042/BCJ20160154. Epub 2016 Jun 8. PMID: 27279651

PsbS interactions involved in the activation of energy dissipation in Arabidopsis.
Correa-Galvis V, Poschmann G, Melzer M, Stühler K, Jahns P. Nat Plants. 2016 Feb 1;2:15225. doi: 10.1038/nplants.2015.225. PMID: 27249196

Minichromosome Maintenance Complex Is a Critical Node in the miR-183 Signaling Network of MYCN-Amplified Neuroblastoma Cells.
Lodrini M, Poschmann G, Schmidt V, Wünschel J, Dreidax D, Witt O, Höfer T, Meyer HE, Stühler K, Eggert A, Deubzer HE. J Proteome Res. 2016 Jul 1;15(7):2178-86. doi: 10.1021/acs.jproteome.6b00134. Epub 2016 Jun 9. PMID: 27239679

MFAP4: a candidate biomarker for hepatic and pulmonary fibrosis?
Mölleken C, Poschmann G, Bonella F, Costabel U, Sitek B, Stühler K, Meyer HE, Schmiegel WH, Marcussen N, Helmer M, Nielsen O, Hansen S, Schlosser A, Holmskov U, Sorensen GL. Sarcoidosis Vasc Diffuse Lung Dis. 2016 Mar 29;33(1):41-50. PMID: 27055835

MicroRNA-15b regulates mitochondrial ROS production and the senescence-associated secretory phenotype through sirtuin 4/SIRT4.
Lang A, Grether-Beck S, Singh M, Kuck F, Jakob S, Kefalas A, Altinoluk-Hambüchen S, Graffmann N, Schneider M, Lindecke A, Brenden H, Felsner I, Ezzahoini H, Marini A, Weinhold S, Vierkötter A, Tigges J, Schmidt S, Stühler K, Köhrer K, Uhrberg M, Haendeler J, Krutmann J, Piekorz RP. Aging (Albany NY). 2016 Mar;8(3):484-505. PMID: 26959556


Publications 2015

Characterization of Regenerative Phenotype of Unrestricted Somatic Stem Cells (USSC) from Human Umbilical Cord Blood (hUCB) by Functional Secretome Analysis.
Schira J, Falkenberg H, Hendricks M, Waldera-Lupa DM, Kögler G, Meyer HE, Müller HW, Stühler K. Mol Cell Proteomics. 2015 Oct;14(10):2630-43. doi: 10.1074/mcp.M115.049312. Epub 2015 Jul 16. PMID: 26183719

Characterization of Skin Aging-Associated Secreted Proteins (SAASP) Produced by Dermal Fibroblasts Isolated from Intrinsically Aged Human Skin.
Waldera Lupa DM, Kalfalah F, Safferling K, Boukamp P, Poschmann G, Volpi E, Götz-Rösch C, Bernerd F, Haag L, Huebenthal U, Fritsche E, Boege F, Grabe N, Tigges J, Stühler K, Krutmann J. J Invest Dermatol. 2015 Aug;135(8):1954-1968. doi: 10.1038/jid.2015.120. Epub 2015 Mar 27. PMID: 25815425

Proteome-wide analysis of in situ aged fibroblasts.
Waldera-Lupa DM, Stühler K. Oncotarget. 2015 Jan 30;6(3):1342-3. No abstract available. PMID: 25633813


Publications 2014

Redox proteomics reveal stress responsive proteins linking peroxiredoxin-1 status in glioma to chemosensitivity and oxidative stress.
Poschmann G, Grzendowski M, Stefanski A, Bruns E, Meyer HE, Stühler K. Biochim Biophys Acta. 2015 Jun;1854(6):624-31. doi: 10.1016/j.bbapap.2014.11.011. Epub 2014 Dec 4. PMID: 25484280

Proteome-wide analysis reveals an age-associated cellular phenotype of in situ aged human fibroblasts.
Waldera-Lupa DM, Kalfalah F, Florea AM, Sass S, Kruse F, Rieder V, Tigges J, Fritsche E, Krutmann J, Busch H, Boerries M, Meyer HE, Boege F, Theis F, Reifenberger G, Stühler K. Aging (Albany NY). 2014 Oct;6(10):856-78. PMID: 25411231

Identification of novel adipokines differential regulated in C57BL/Ks and C57BL/6.
Hartwig S, Goeddeke S, Poschmann G, Dicken HD, Jacob S, Nitzgen U, Passlack W, Stühler K, Ouwens DM, Al-Hasani H, Knebel B, Kotzka J, Lehr S. Arch Physiol Biochem. 2014 Dec;120(5):208-15. doi: 10.3109/13813455.2014.970197. Epub 2014 Oct 16. PMID: 25319219

How stemlike are sphere cultures from long-term cancer cell lines? Lessons from mouse glioma models.
Ahmad M, Frei K, Willscher E, Stefanski A, Kaulich K, Roth P, Stühler K, Reifenberger G, Binder H, Weller M. J Neuropathol Exp Neurol. 2014 Nov;73(11):1062-77. doi: 10.1097/NEN.0000000000000130. PMID: 25289892

Novel prognostic markers revealed by a proteomic approach separating benign from malignant insulinomas.
Alkatout I, Friemel J, Sitek B, Anlauf M, Eisenach PA, Stühler K, Scarpa A, Perren A, Meyer HE, Knoefel WT, Klöppel G, Sipos B. Mod Pathol. 2015 Jan;28(1):69-79. doi: 10.1038/modpathol.2014.82. Epub 2014 Jun 20. PMID: 24947143

Zebrafish heart development is regulated via glutaredoxin 2 dependent migration and survival of neural crest cells.
Berndt C, Poschmann G, Stühler K, Holmgren A, Bräutigam L. Redox Biol. 2014 May 2;2:673-8. doi: 10.1016/j.redox.2014.04.012. eCollection 2014. PMID: 24944912

Evolution of the Phosphoenolpyruvate Carboxylase Protein Kinase Family in C3 and C4 Flaveria spp.
Aldous SH, Weise SE, Sharkey TD, Waldera-Lupa DM, Stühler K, Mallmann J, Groth G, Gowik U, Westhoff P, Arsova B. Plant Physiol. 2014 Jul;165(3):1076-1091. Epub 2014 May 21. PMID: 24850859

The hallmarks of fibroblast ageing.
Tigges J, Krutmann J, Fritsche E, Haendeler J, Schaal H, Fischer JW, Kalfalah F, Reinke H, Reifenberger G, Stühler K, Ventura N, Gundermann S, Boukamp P, Boege F. Mech Ageing Dev. 2014 Jun;138:26-44. doi: 10.1016/j.mad.2014.03.004. Epub 2014 Mar 29. Review. PMID: 24686308

High-fat diet induced isoform changes of the Parkinson's disease protein DJ-1.
Poschmann G, Seyfarth K, Besong Agbo D, Klafki HW, Rozman J, Wurst W, Wiltfang J, Meyer HE, Klingenspor M, Stühler K. J Proteome Res. 2014 May 2;13(5):2339-51. doi: 10.1021/pr401157k. Epub 2014 Mar 28. PMID: 24646099

Biomarkers: a proteomic challenge. Preface.
Stühler K, Poschmann G. Biochim Biophys Acta. 2014 May;1844(5):859-60. doi: 10.1016/j.bbapap.2014.02.020. Epub 2014 Feb 28. No abstract available. PMID: 24590111


Publications 2013

Glutaredoxin regulates vascular development by reversible glutathionylation of sirtuin 1.
Bräutigam L, Jensen LD, Poschmann G, Nyström S, Bannenberg S, Dreij K, Lepka K, Prozorovski T, Montano SJ, Aktas O, Uhlén P, Stühler K, Cao Y, Holmgren A, Berndt C. Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):20057-62. doi: 10.1073/pnas.1313753110. Epub 2013 Nov 25. PMID: 24277839

The p90 ribosomal S6 kinase (RSK) inhibitor BI-D1870 prevents gamma irradiation-induced apoptosis and mediates senescence via RSK- and p53-independent accumulation of p21WAF1/CIP1.
Neise D, Sohn D, Stefanski A, Goto H, Inagaki M, Wesselborg S, Budach W, Stühler K, Jänicke RU. Cell Death Dis. 2013 Oct 17;4:e859. doi: 10.1038/cddis.2013.386. PMID: 24136223

Development of a capillary isoelectric focusing immunoassay to measure DJ-1 isoforms in biological samples.
Besong Agbo D, Klafki H, Poschmann G, Seyfarth K, Genius J, Janßen C, Stühler K, Wurst W, Meyer HE, Klingenspor M, Wiltfang J. Anal Biochem. 2013 Dec 15;443(2):197-204. doi: 10.1016/j.ab.2013.09.013. Epub 2013 Sep 17. PMID: 24055619

The fate of b-ions in the two worlds of collision-induced dissociation.
Waldera-Lupa DM, Stefanski A, Meyer HE, Stühler K. Biochim Biophys Acta. 2013 Dec;1834(12):2843-8. doi: 10.1016/j.bbapap.2013.08.007. Epub 2013 Aug 28. PMID: 23994226

Global protein profiling reveals anti-EGFR monoclonal antibody 806-modulated proteins in A431 tumor xenografts.
Lee ST, Ji H, Greening DW, Speirs RW, Rigopoulos A, Pillay V, Murone C, Vitali A, Stühler K, Johns TG, Corner GA, Mariadason JM, Simpson RJ, Scott AM. Growth Factors. 2013 Oct;31(5):154-64. doi: 10.3109/08977194.2013.824435. Epub 2013 Aug 20. PMID: 23957735

A combination of two electrophoretical approaches for detailed proteome-based characterization of SCLC subtypes.
Poschmann G, Lendzian A, Uszkoreit J, Eisenacher M, Borght AV, Ramaekers FC, Meyer HE, Stühler K. Arch Physiol Biochem. 2013 Jul;119(3):114-25. doi: 10.3109/13813455.2013.789529. Epub 2013 May 8. PMID: 23651173

Proteomic Profiling of Ex Vivo Expanded CD34-Positive Haematopoetic Cells Derived from Umbilical Cord Blood.
Falkenberg H, Radke TF, Kögler G, Stühler K. Stem Cells Int. 2013;2013:245695. doi: 10.1155/2013/245695. Epub 2013 Mar 26. PMID: 23606859

Tra2-mediated recognition of HIV-1 5' splice site D3 as a key factor in the processing of vpr mRNA.
Erkelenz S, Poschmann G, Theiss S, Stefanski A, Hillebrand F, Otte M, Stühler K, Schaal H. J Virol. 2013 Mar;87(5):2721-34. doi: 10.1128/JVI.02756-12. Epub 2012 Dec 19. PMID: 23255807


Publications 2012

Application of label-free proteomics for differential analysis of lung carcinoma cell line A549.
Sitek B, Waldera-Lupa DM, Poschmann G, Meyer HE, Stühler K. Methods Mol Biol. 2012;893:241-8. doi: 10.1007/978-1-61779-885-6_16. PMID: 22665305

Application of saturation labeling in lung cancer proteomics.
Poschmann G, Sitek B, Sipos B, Stühler K. Methods Mol Biol. 2012;854:253-67. doi: 10.1007/978-1-61779-573-2_18. PMID: 22311766

The proteomic signature of insulin-resistant human skeletal muscle reveals increased glycolytic and decreased mitochondrial enzymes.
Giebelstein J, Poschmann G, Højlund K, Schechinger W, Dietrich JW, Levin K, Beck-Nielsen H, Podwojski K, Stühler K, Meyer HE, Klein HH. Diabetologia. 2012 Apr;55(4):1114-27. doi: 10.1007/s00125-012-2456-x. Epub 2012 Jan 27. Erratum in: Diabetologia. 2012 Jul;55(7):2083. PMID: 22282162


Publications 2011

Downregulation of PRDX1 by promoter hypermethylation is frequent in 1p/19q-deleted oligodendroglial tumours and increases radio- and chemosensitivity of Hs683 glioma cells in vitro.
Dittmann LM, Danner A, Gronych J, Wolter M, Stühler K, Grzendowski M, Becker N, Bageritz J, Goidts V, Toedt G, Felsberg J, Sabel MC, Barbus S, Reifenberger G, Lichter P, Tews B. Oncogene. 2012 Jul 19;31(29):3409-18. doi: 10.1038/onc.2011.513. Epub 2011 Dec 12. PMID: 22158042

Keratin 23, a novel DPC4/Smad4 target gene which binds 14-3-3ε.
Liffers ST, Maghnouj A, Munding JB, Jackstadt R, Herbrand U, Schulenborg T, Marcus K, Klein-Scory S, Schmiegel W, Schwarte-Waldhoff I, Meyer HE, Stühler K, Hahn SA. BMC Cancer. 2011 Apr 14;11:137. doi: 10.1186/1471-2407-11-137. PMID: 21492476


Publications 2010

Proteome-wide identification of mycobacterial pupylation targets.
Poulsen C, Akhter Y, Jeon AH, Schmitt-Ulms G, Meyer HE, Stefanski A, Stühler K, Wilmanns M, Song YH. Mol Syst Biol. 2010 Jul 13;6:386. doi: 10.1038/msb.2010.39. PMID: 20631680

Immunoscreening of the extracellular proteome of colorectal cancer cells.
Klein-Scory S, Kübler S, Diehl H, Eilert-Micus C, Reinacher-Schick A, Stühler K, Warscheid B, Meyer HE, Schmiegel W, Schwarte-Waldhoff I. BMC Cancer. 2010 Feb 25;10:70. doi: 10.1186/1471-2407-10-70. PMID: 20184735

Differential proteome analysis of human gliomas stratified for loss of heterozygosity on chromosomal arms 1p and 19q.
Grzendowski M, Wolter M, Riemenschneider MJ, Knobbe CB, Schlegel U, Meyer HE, Reifenberger G, Stühler K. Neuro Oncol. 2010 Mar;12(3):243-56. doi: 10.1093/neuonc/nop025. Epub 2010 Jan 7. PMID: 20167812


Publications 2009

Simultaneous extraction of nucleic acids and proteins from tissue specimens by ultracentrifugation: A protocol using the high-salt protein fraction for quantitative proteome analysis.
Grzendowski M, Riemenschneider MJ, Hawranke E, Stefanski A, Meyer HE, Reifenberger G, Stühler K. Proteomics. 2009 Nov;9(21):4985-90. doi: 10.1002/pmic.200800902. PMID: 19810030

Proteomic analysis of astroglial connexin43 silencing uncovers a cytoskeletal platform involved in process formation and migration.
Olk S, Turchinovich A, Grzendowski M, Stühler K, Meyer HE, Zoidl G, Dermietzel R. Glia. 2010 Mar;58(4):494-505. doi: 10.1002/glia.20942. PMID: 19795503

Identification and functional characterization of microRNAs involved in the malignant progression of gliomas.
Malzkorn B, Wolter M, Liesenberg F, Grzendowski M, Stühler K, Meyer HE, Reifenberger G. Brain Pathol. 2010 May;20(3):539-50. doi: 10.1111/j.1750-3639.2009.00328.x. Epub 2009 Sep 19. PMID: 19775293

Unintended spread of a biosafety level 2 recombinant retrovirus.
Stang A, Petrasch-Parwez E, Brandt S, Dermietzel R, Meyer HE, Stühler K, Liffers ST, Uberla K, Grunwald T. Retrovirology. 2009 Sep 22;6:86. doi: 10.1186/1742-4690-6-86. PMID: 19772602

Analysis of the pancreatic tumor progression by a quantitative proteomic approach and immunhistochemical validation.
Sitek B, Sipos B, Alkatout I, Poschmann G, Stephan C, Schulenborg T, Marcus K, Lüttges J, Dittert DD, Baretton G, Schmiegel W, Hahn SA, Klöppel G, Meyer HE, Stühler K. J Proteome Res. 2009 Apr;8(4):1647-56. doi: 10.1021/pr800890j. PMID: 19714807

Cell-based proteome analysis: the first stage in the pipeline for biomarker discovery.
Poschmann G, Sitek B, Sipos B, Hamacher M, Vonend O, Meyer HE, Stühler K. Biochim Biophys Acta. 2009 Sep;1794(9):1309-16. doi: 10.1016/j.bbapap.2009.07.001. Epub 2009 Jul 10. Review. PMID: 19595794

Difference gel electrophoresis.
Minden JS, Dowd SR, Meyer HE, Stühler K. Electrophoresis. 2009 Jun;30 Suppl 1:S156-61. doi: 10.1002/elps.200900098. Review. PMID: 19517495

High-resolution 2DE.
Marcus K, Joppich C, May C, Pfeiffer K, Sitek B, Meyer H, Stuehler K. Methods Mol Biol. 2009;519:221-40. doi: 10.1007/978-1-59745-281-6_14. PMID: 19381586

Identification of glycoprotein receptors within the human salivary proteome for the lectin-like BabA and SabA adhesins of Helicobacter pylori by fluorescence-based 2-D bacterial overlay.
Walz A, Odenbreit S, Stühler K, Wattenberg A, Meyer HE, Mahdavi J, Borén T, Ruhl S. Proteomics. 2009 Mar;9(6):1582-92. doi: 10.1002/pmic.200700808. PMID: 19253298

Detection of novel biomarkers of liver cirrhosis by proteomic analysis.
Mölleken C, Sitek B, Henkel C, Poschmann G, Sipos B, Wiese S, Warscheid B, Broelsch C, Reiser M, Friedman SL, Tornøe I, Schlosser A, Klöppel G, Schmiegel W, Meyer HE, Holmskov U, Stühler K. Hepatology. 2009 Apr;49(4):1257-66. doi: 10.1002/hep.22764. PMID: 19177598

Retention time alignment algorithms for LC/MS data must consider non-linear shifts.
Podwojski K, Fritsch A, Chamrad DC, Paul W, Sitek B, Stühler K, Mutzel P, Stephan C, Meyer HE, Urfer W, Ickstadt K, Rahnenführer J. Bioinformatics. 2009 Mar 15;25(6):758-64. doi: 10.1093/bioinformatics/btp052. Epub 2009 Jan 28. PMID: 19176558

Identification of proteomic differences between squamous cell carcinoma of the lung and bronchial epithelium.
Poschmann G, Sitek B, Sipos B, Ulrich A, Wiese S, Stephan C, Warscheid B, Klöppel G, Vander Borght A, Ramaekers FC, Meyer HE, Stühler K. Mol Cell Proteomics. 2009 May;8(5):1105-16. doi: 10.1074/mcp.M800422-MCP200. Epub 2009 Jan 27. PMID: 19176476


Publications 2008

Brain-specific proteins decline in the cerebrospinal fluid of humans with Huntington disease.
Fang Q, Strand A, Law W, Faca VM, Fitzgibbon MP, Hamel N, Houle B, Liu X, May DH, Poschmann G, Roy L, Stühler K, Ying W, Zhang J, Zheng Z, Bergeron JJ, Hanash S, He F, Leavitt BR, Meyer HE, Qian X, McIntosh MW. Mol Cell Proteomics. 2009 Mar;8(3):451-66. doi: 10.1074/mcp.M800231-MCP200. Epub 2008 Nov 4. PMID: 18984577

Early leaf senescence is associated with an altered cellular redox balance in Arabidopsis cpr5/old1 mutants.
Jing HC, Hebeler R, Oeljeklaus S, Sitek B, Stühler K, Meyer HE, Sturre MJ, Hille J, Warscheid B, Dijkwel PP. Plant Biol (Stuttg). 2008 Sep;10 Suppl 1:85-98. doi: 10.1111/j.1438-8677.2008.00087.x. PMID: 18721314

The glomerular proteome in a model of chronic kidney disease.
Potthoff SA, Sitek B, Stegbauer J, Schulenborg T, Marcus K, Quack I, Rump LC, Meyer HE, Stühler K, Vonend O. Proteomics Clin Appl. 2008 Jul;2(7-8):1127-39. doi: 10.1002/prca.200800010. PMID: 21136910

Establishment of "one-piece" large-gel 2-DE for high-resolution analysis of small amounts of sample using difference gel electrophoresis saturation labelling.
Sitek B, Sipos B, Pfeiffer K, Grzendowski M, Poschmann G, Hawranke E, Köper K, Klöppel G, Meyer HE, Stühler K. Anal Bioanal Chem. 2008 May;391(1):361-5. doi: 10.1007/s00216-008-2042-8. Epub 2008 Apr 1. PMID: 18379760

Application of fluorescence dye saturation labeling for differential proteome analysis of 1,000 microdissected cells from pancreatic ductal adenocarcinoma precursor lesions.
Sitek B, Sipos B, Klöppel G, Schmiegel W, Hahn SA, Meyer HE, Stühler K. Methods Mol Biol. 2008;425:1-14. doi: 10.1007/978-1-60327-210-0_1. PMID: 18369882

New insight into stimulus-induced plasticity of the olfactory epithelium in Mus musculus by quantitative proteomics.
Barbour J, Neuhaus EM, Piechura H, Stoepel N, Mashukova A, Brunert D, Sitek B, Stühler K, Meyer HE, Hatt H, Warscheid B. J Proteome Res. 2008 Apr;7(4):1594-605. doi: 10.1021/pr7005796. Epub 2008 Mar 13. PMID: 18336002


Publications 2007

High-performance proteomics as a tool in biomarker discovery.
Meyer HE, Stühler K. Proteomics. 2007 Sep;7 Suppl 1:18-26. PMID: 17893859

Study of early leaf senescence in Arabidopsis thaliana by quantitative proteomics using reciprocal 14N/15N labeling and difference gel electrophoresis.
Hebeler R, Oeljeklaus S, Reidegeld KA, Eisenacher M, Stephan C, Sitek B, Stühler K, Meyer HE, Sturre MJ, Dijkwel PP, Warscheid B. Mol Cell Proteomics. 2008 Jan;7(1):108-20. Epub 2007 Sep 18. PMID: 17878269


Publications 2006

A catalogue of proteins released by colorectal cancer cells in vitro as an alternative source for biomarker discovery.
Diehl HC, Stühler K, Klein-Scory S, Volmer MW, Schöneck A, Bieling C, Schmiegel W, Meyer HE, Schwarte-Waldhoff I. Proteomics Clin Appl. 2007 Jan;1(1):47-61. doi: 10.1002/prca.200600491. Epub 2006 Dec 5. PMID: 21136611

Changes of the hepatic proteome in murine models for toxically induced fibrogenesis and sclerosing cholangitis.
Henkel C, Roderfeld M, Weiskirchen R, Berres ML, Hillebrandt S, Lammert F, Meyer HE, Stühler K, Graf J, Roeb E. Proteomics. 2006 Dec;6(24):6538-48. PMID: 17109383

Differential proteome analysis of colon carcinoma cell line SW480 after reconstitution of the tumour suppressor Smad4.
Stühler K, Köper K, Pfeiffer K, Tagariello A, Souquet M, Schwarte-Waldhoff I, Hahn SA, Schmiegel W, Meyer HE. Anal Bioanal Chem. 2006 Nov;386(6):1603-12. Epub 2006 Oct 17. PMID: 17043799

HUPO Brain Proteome Project: summary of the pilot phase and introduction of a comprehensive data reprocessing strategy.
Hamacher M, Apweiler R, Arnold G, Becker A, Blüggel M, Carrette O, Colvis C, Dunn MJ, Fröhlich T, Fountoulakis M, van Hall A, Herberg F, Ji J, Kretzschmar H, Lewczuk P, Lubec G, Marcus K, Martens L, Palacios Bustamante N, Park YM, Pennington SR, Robben J, Stühler K, Reidegeld KA, Riederer P, Rossier J, Sanchez JC, Schrader M, Stephan C, Tagle D, Thiele H, Wang J, Wiltfang J, Yoo JS, Zhang C, Klose J, Meyer HE. Proteomics. 2006 Sep;6(18):4890-8. Erratum in: Proteomics. 2006 Oct;6(20):5674. Ji, Juango [corrected to Ji, Jianguo]. PMID: 16927433

Examination of 2-DE in the Human Proteome Organisation Brain Proteome Project pilot studies with the new RAIN gel matching technique.
Dowsey AW, English J, Pennington K, Cotter D, Stuehler K, Marcus K, Meyer HE, Dunn MJ, Yang GZ. Proteomics. 2006 Sep;6(18):5030-47. PMID: 16927431

Pilot study of the Human Proteome Organisation Brain Proteome Project: applying different 2-DE techniques to monitor proteomic changes during murine brain development.
Stühler K, Pfeiffer K, Joppich C, Stephan C, Jung K, Müller M, Schmidt O, van Hall A, Hamacher M, Urfer W, Meyer HE, Marcus K. Proteomics. 2006 Sep;6(18):4899-913. PMID: 16927428

Novel approaches to analyse glomerular proteins from smallest scale murine and human samples using DIGE saturation labelling.
Sitek B, Potthoff S, Schulenborg T, Stegbauer J, Vinke T, Rump LC, Meyer HE, Vonend O, Stühler K. Proteomics. 2006 Aug;6(15):4337-45. PMID: 16819728

Proteome analysis of glandular parotid and submandibular-sublingual saliva in comparison to whole human saliva by two-dimensional gel electrophoresis.
Walz A, Stühler K, Wattenberg A, Hawranke E, Meyer HE, Schmalz G, Blüggel M, Ruhl S. Proteomics. 2006 Mar;6(5):1631-9. PMID: 16402355


Publications 2005

Application of fluorescence difference gel electrophoresis saturation labelling for the analysis of microdissected precursor lesions of pancreatic ductal adenocarcinoma.
Sitek B, Lüttges J, Marcus K, Klöppel G, Schmiegel W, Meyer HE, Hahn SA, Stühler K. Proteomics. 2005 Jul;5(10):2665-79. PMID: 15924292

Differential proteome analysis of conditioned media to detect Smad4 regulated secreted biomarkers in colon cancer.
Volmer MW, Stühler K, Zapatka M, Schöneck A, Klein-Scory S, Schmiegel W, Meyer HE, Schwarte-Waldhoff I. Proteomics. 2005 Jul;5(10):2587-601. PMID: 15912508

Identification of dynamic proteome changes upon ligand activation of Trk-receptors using two-dimensional fluorescence difference gel electrophoresis and mass spectrometry.
Sitek B, Apostolov O, Stühler K, Pfeiffer K, Meyer HE, Eggert A, Schramm A. Mol Cell Proteomics. 2005 Mar;4(3):291-9. Epub 2005 Jan 15. Erratum in: Mol Cell Proteomics. 2005 Aug;4(8):1210. PMID: 15654083


Publications 2004

MALDI: more than peptide mass fingerprints.
Stühler K, Meyer HE. Curr Opin Mol Ther. 2004 Jun;6(3):239-48. Review. PMID: 15264426

Tumor suppressor Smad4 mediates downregulation of the anti-adhesive invasion-promoting matricellular protein SPARC: Landscaping activity of Smad4 as revealed by a "secretome" analysis.
Volmer MW, Radacz Y, Hahn SA, Klein-Scory S, Stühler K, Zapatka M, Schmiegel W, Meyer HE, Schwarte-Waldhoff I. Proteomics. 2004 May;4(5):1324-34. PMID: 15188399

Evaluation of algorithms for protein identification from sequence databases using mass spectrometry data.
Chamrad DC, Körting G, Stühler K, Meyer HE, Klose J, Blüggel M. Proteomics. 2004 Mar;4(3):619-28. PMID: 14997485


Publications 2003

Proteomics: techniques and applications in cancer research.
Schramm A, Apostolov O, Sitek B, Pfeiffer K, Stühler K, Meyer HE, Havers W, Eggert A. Klin Padiatr. 2003 Nov-Dec;215(6):293-7. PMID: 14677091


Publications 2002

Genetic analysis of the mouse brain proteome.
Klose J, Nock C, Herrmann M, Stühler K, Marcus K, Blüggel M, Krause E, Schalkwyk LC, Rastan S, Brown SD, Büssow K, Himmelbauer H, Lehrach H. Nat Genet. 2002 Apr;30(4):385-93. Epub 2002 Mar 25.

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