Research topics and principle investigators of the RTG 2578

Distinct human and murine in vitro cellular differentiation models that represent different germ layers are used within the RTG 2578 in order to analyse the response of individual stem- and progenitor cells to model-relevant genotoxic agents. The implementation of various test systems and well-defined genotoxins together with an extensive analysis of relevant end points will foster multidisciplinary knowledge acquisition in genetic and developmental toxicology. As a result of the networked scientific research, synergistic effects are anticipated that favour knowledge in both basic research and translational concepts in distinct areas.
List of research topics and principle investigators (PIs) of the RTG 2578
1a - Comparative analyses of DNA damage response pathways in hepatocytes and neurons differentiated from healthy and NBS-patient derived iPSCs. PI: Adjaye
1b - Hypoxia and Sirtuin 1, two factors linking DNA damage and differentiation in neural stem/ progenitor cells. PIs: Aktas/Berndt
1c -Investigations on DNA repair capacities of human neural progenitor cells (NPC) depending on the degree of differentiation and cell type. PI: Fritsche
1d - Molecular mechanisms regulating the differentiation potential of neural stem and progenitor cells upon gamma irradiation. PIs: Rose/Knobbe-Thomsen
1e - Impact of genotoxins on autophagic processes during neuronal differentiation. PIs: Stork/Adjaye
2a - Effect of DNA damage caused by nephrotoxins and oxidative stress on differentiation and dedifferentiation processes in kidney cells. PI: Schupp
3b - Sublethal Genomic Damage of Naïve B cells - Consequences for Differentiation and Function with a Focus on Development of Autoimmunity. PI: Pongratz
4 - Influence of nitrosamines and ionizing radiation on the chondrogenic differentiation potential of neonatal and adult stromal cells. PIs: Kögler/Wesselborg
5b - Role of metabolism and mitochondrial function for stem cell differentiation and stress responses upon genotoxic noxae. PIs: Reichert/Fritz