Distinct human and murine in vitro cellular differentiation models that represent different germ layers are used within the RTG 2578 in order to analyse the response of individual stem- and progenitor cells to model-relevant genotoxic agents. The implementation of various test systems and well-defined genotoxins together with an extensive analysis of relevant end points will foster multidisciplinary knowledge acquisition in genetic and developmental toxicology. As a result of the networked scientific research, synergistic effects are anticipated that favour knowledge in both basic research and translational concepts in distinct areas.
List of research topics and principle investigators (PIs) of the RTG 2578
1e - Impact of genotoxins on autophagic processes during neuronal differentiation. PIs: Stork/Adjaye
3a - Impact of hemato-oncological therapies on genomic stability and differentiation capacity of human bone marrow-derived mesenchymal stromal cells in the context of therapy-related hematopoietic insufficiency and development of secondary myeloid neoplasms. PI: Schroeder