Publikationen 2018

Hoogeveen RC, Robidoux MP, Schwarz T, Heydmann L, Cheney JA, Kvistad D, Aneja J, Melgaço JG, Fernandes CA, Chung RT, Boonstra A, Kim AY, Baumert TF, Timm J, Lewis-Ximenez LL, Tonnerre P, Lauer GM. Phenotype and function of HBV-specific T cells is determined by the targeted epitope in addition to the stage of infection. Gut. 2018 Dec 22. pii: gutjnl-2018-316644.

Costa R, Todt D, Zapatero-Belinchón F, Schenk C, Anastasiou OE, Walker A, Hertel B, Timmer L, Bojkova D, Ruckert M, Sarrazin C, Timm J, Lohmann V, Manns MP, Steinman E, Hahn TV, Ciesek S. SEC14L2, a lipid-binding protein, regulate HCV replication in culture with inter- and intra- genotype variations. J Hepatol. 2018 Nov 22. pii: S0168-8278(18)32544-3.

Kaisers W, Schwender H, Schaal H. Hierarchical Clustering of DNA k-mer Counts in RNAseq Fastq Files Identifies Sample Heterogeneities. Int J Mol Sci. 2018 Nov 21;19(11). pii: E3687.

Lundtoft C, Awuah AA, Güler A, Harling K, Schaal H, Mayatepek E, Phillips RO, Nausch N, Owusu-Dabo E, Jacobsen M. An IL7RA exon 5 polymorphism is associated with impaired IL-7Rα splicing and protection against tuberculosis in Ghana. Genes Immun. 2018 Oct 31. doi: 10.1038/s41435-018-0049-5

Erkelenz S, Theiss S, Kaisers W, Ptok J, Walotka L, Müller L, Hillebrand F, Brillen AL, Sladek M, Schaal H. Ranking noncanonical 5' splice site usage by genome-wide RNA-seq analysis and splicing reporter assays. Genome Res. 2018 Dec;28(12):1826-1840.

Gössling KL, Fouz H, Kyrillopoulou O, Aubin M, Maecker-Kolhoff B, Adams O, Borkhardt A, Babor F, Schuster FR, Siepermann M, Schumm M, Lang P, Eiz-Vesper B, Meisel R. Clearance of treatment-refractory adenoviremia via adenovirus-specific donor T-cell transfer during aplasia after αβTCR-CD19-depleted stem cell transplantation. Clin Infect Dis. 2018 Oct 24. doi: 10.1093/cid/ciy820.

Anastasiou OE, Widera M, Westhaus S, Timmer L, Korth J, Gerken G, Canbay A, Todt D, Steinmann E, Schwarz T, Timm J, Verheyen J, Ciesek S. Clinical outcome and viral genome variability of hepatitis B virus induced acute liver failure (HEP-18-0579). Hepatology. 2018 Sep 19. doi: 10.1002/hep.30279.

Jaguva Vasudevan AA, Bähr A, Grothmann R, Singer A, Häussinger D, Zimmermann A*, Münk C. MXB inhibits murine cytomegalovirus. Virology. 2018 Sep;522:158-167. *corresponding author

Herrmann A, Sandmann L, Adams O, Herrmann D, Dirks M, Widera M, Westhaus S, Kaiser R, di Cristanziano V, Manns MP, Korth J, Richter N, Anastasiou O, Timm J, von Hahn T, Ciesek S. Role of BK polyomavirus (BKV) and Torque teno virus (TTV) in liver transplant recipients with renal impairment.  J Med Microbiol. 2018 Oct;67(10):1496-1508.

Thoens C, Heinold A, Lindemann M, Horn PA, Chang DI, Scherbaum N, Timm J, Heinemann FM. A single nucleotide polymorphism upstream of the HLA-C locus is associated with an anti-HCV seronegative state in a high-risk exposed cohort. J Infect Dis. 2018 Nov 5;218(12):2016-2019.

Scherbaum N, Timm J, Richter F, Bonnet U, Bombeck J, Lajos S, Specka M. Outcome of a hepatitis B vaccination program for clients of a drug consumption facility. J Clin Virol. 2018 Apr 23;106:28-32.

Khairnar V, Duhan V, Patil AM, Zhou F, Bhat H, Thoens C, Sharma P, Adomati T, Friendrich SK, Bezgovsek J, Dreesen JD, Wennemuth G, Westendorf AM, Zelinskyy G, Dittmer U, Hardt C, Timm J, Göthert JR, Lang PA, Singer BB, Lang KS. CEACAM1 promotes CD8+ T cell responses and improves control of a chronic viral infection. Nat Commun. 2018 Jul 2;9 (1):2561.

Parczewski M, Kordek J, Janczewska E, Pisula A, Łojewski W, Socha Ł, Wawrzynowicz-Syczewska M, Bociąga-Jasik M, Szymczak A, Cielniak I, Siwak E, Mularska E, Aksak-Wąs B, Urbańska A, Luebke N. HCV-genotype 1 NS5A RAVs are associated with advanced liver fibrosis independently of HCV-transmission clusters.Clin Microbiol Infect. 2018 Jul 5. pii: S1198-743X(18)30493-2.

Rattay S, Graf D, Kislat A, Homey B, Herebian D, Häussinger D, Hengel H, Zimmermann A*, Schupp AK. Anti-inflammatory consequences of bile acid accumulation in virus-infected bile duct ligated mice. PLoS One. 2018 Jun 28;13(6):e0199863. *corresponding author

Sarrazin C, Zimmermann T, Berg T, Neumann UP, Schirmacher P, Schmidt H, Spengler U, Timm J, Wedemeyer H, Wirth S, Zeuzem S; Deutsche Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS); Deutsche Gesellschaft für Pathologie e.V. (DGP); Deutsche Leberstiftung; Gesellschaft für Virologie e.V. (GfV); Gesellschaft für Pädiatrische Gastroenterologie und Ernährung (GPGE); Österreichische Gesellschaft für Gastroenterologie und Hepatologie (ÖGGH); Schweizerische Gesellschaft für Gastroenterologie (SGG); Deutsche Transplantationsgesellschaft e.V. (DTG); Deutsche Leberhilfe e.V; Deutsche Gesellschaft für Infektiologie e.V. (DGI); Deutsche Gesellschaft für Suchtmedizin e.V. (DGS); Deutsche AIDS-Gesellschaft e.V. (DAIG); Deutsche Arbeitsgemeinschaft niedergelassener Ärzte für die Versorgung HIV-Infizierter (DAGNÄ); Robert Koch-Institut. [Prophylaxis, diagnosis and therapy of hepatitis-C-virus (HCV) infection: the German guidelines on the management of HCV infection - AWMF-Register-No.: 021/012]. Z Gastroenterol. 2018 Jun 26. doi: 10.1055/a-0599-1320.German

Karimzadeh H, Kiraithe MM, Kosinska AD, Glaser M, Fiedler M, Oberhardt V, Salimi Alizei E, Hofmann M, Mok JY, Nguyen M, van Esch WJE, Budeus B, Grabowski J, Homs M, Olivero A, Keyvani H, Rodríguez-Frías F, Tabernero D, Buti M, Heinold A, Alavian SM, Bauer T, Schulze Zur Wiesch J, Raziorrouh B, Hoffmann D, Smedile A, Rizzetto M, Wedemeyer H, Timm J, Antes I, Neumann-Haefelin C, Protzer U, Roggendorf M. Amino Acid Substitutions within HLA-B*27-Restricted T Cell Epitopes Prevent Recognition by Hepatitis Delta Virus-Specific CD8+ T Cells. J Virol. 2018 Jun 13;92(13). pii: e01891-17.

Ali S, Hoven A, Dress RJ, Schaal H, Alferink J, Scheu S. Identification of a novel Dlg2 isoform differentially expressed in IFNβ-producing plasmacytoid dendritic cells. BMC Genomics. 2018 Mar 12;19(1):194.

Parczewski M, Cielniak I, Kordek J, Aksak-Wąs B, Urbańska A, Leszczyszyn-Pynka M, Siwak E, Bociąga-Jasik M, Nowak A, Szymczak A, Zalewska M, Łojewski W, Vandamme AM, Lübke N, Cuypers L. Transmission Networks of HCV Genotype 1a Enriched With Pre-existing Polymorphism Q80K Among HIV-Infected Patients With Acute Hepatitis C in Poland. J Acquir Immune Defic Syndr. 2018 Apr 15;77(5):514-522

Lawand M, Evnouchidou I, Baranek T, Montealegre S, Tao S, Drexler I, Saveanu L, Si-Tahar M, van Endert P. Impact of the TAP-like transporter in antigen presentation and phagosome maturation. Mol Immunol. 2018 Jun 23. pii: S0161-5890(18)30483-8.

Ghosh S, Drexler I, Bhatia S, Gennery AR, Borkhardt A. Interleukin-2-Inducible T-Cell Kinase Deficiency-New Patients, New Insight? Front Immunol. 2018 May 8;9:979.

Luteijn RD, Drexler I, Smith GL, Lebbink RJ, Wiertz EJHJ. Mutagenic repair of double-stranded DNA breaks in vaccinia virus genomes requires cellular DNA ligase IV activity in the cytosol. J Gen Virol. 2018 Jun;99(6):790-804

Motte J, Kneiphof J, Straßburger-Krogias K, Klasing A, Adams O, Haghikia A, Gold R. Detection of JC virus archetype in cerebrospinal fluid in a MS patient with dimethylfumarate treatment without lymphopenia or signs of PML. J Neurol. 2018 Aug;265(8):1880-1882

von Felden J, Vermehren J, Ingiliz P, Mauss S, Lutz T, Simon KG, Busch HW, Baumgarten A, Schewe K, Hueppe D, Boesecke C, Rockstroh JK, Daeumer M, Luebke N, Timm J, Schulze Zur Wiesch J, Sarrazin C, Christensen S. High efficacy of sofosbuvir/velpatasvir and impact of baseline resistance-associated substitutions in hepatitis C genotype 3 infection. Aliment Pharmacol Ther. 2018 May;47(9):1288-1295.

Milo I, Blecher-Gonen R, Barnett-Itzhaki Z, Bar-Ziv R, Tal O, Gurevich I, Feferman T, Drexler I, Amit I, Bousso P, Shakhar G. The bone marrow is patrolled by NK cells that are primed and expand in response to systemic viral activation. Eur J Immunol. 2018 Jul;48(7):1137-1152.

 Krawczyk A, Ackermann J, Goitowski B, Trenschel R, Ditschkowski M, Timm J, Ottinger H, Beelen DW, Grüner N, Fiedler M. Assessing the risk of CMV reactivation and reconstitution of antiviral immune response post bone marrow transplantation by the QuantiFERON-CMV-assay and real time PCR. J Clin Virol. 2018 Jan 9;99-100:61-66

Sertznig H, Hillebrand F, Erkelenz S, Schaal H, Widera M. Behind the scenes of HIV-1 replication: Alternative splicing as the dependency factor on the quiet. Virology. 2018; 516:176-188. Review.

Dahm T, Adams O, Boettcher S, Diedrich S, Morozov V, Hansman G, Fallier-Becker P, Schädler S, Burkhardt CJ, Weiss C, Stump-Guthier C, Ishikawa H, Schroten H, Schwerk C, Tenenbaum T, Rudolph H. Strain-dependent effects of clinical echovirus 30 outbreak isolates at the blood-CSF barrier. J Neuroinflammation. 2018 Feb 20;15(1):50.

Harvala H, Broberg E, Benschop K, Berginc N, Ladhani S, Susi P, Christiansen C, McKenna J, Allen D, Makiello P, McAllister G, Carmen M, Zakikhany K, Dyrdak R, Nielsen X, Madsen T, Paul J, Moore C, von Eije K, Piralla A, Carlier M, Vanoverschelde L, Poelman R, Anton A, López-Labrador FX, Pellegrinelli L, Keeren K, Maier M, Cassidy H, Derdas S, Savolainen-Kopra C, Diedrich S, Nordbø S, Buesa J, Bailly JL, Baldanti F, MacAdam A, Mirand A, Dudman S, Schuffenecker I, Kadambari S, Neyts J, Griffiths MJ, Richter J, Margaretto C, Govind S, Morley U, Adams O, Krokstad S, Dean J, Pons-Salort M, Prochazka B, Cabrerizo M, Majumdar M, Nebbia G, Wiewel M, Cottrell S, Coyle P, Martin J, Moore C, Midgley S, Horby P, Wolthers K, Simmonds P, Niesters H, Fischer TK. Recommendations for enterovirus diagnostics and characterisation within and beyond Europe. J Clin Virol. 2018 Feb 6;101:11-17. Review.

 Knops E, Heger E, Koenig C, Moebius U, Lübke N, Kaiser R, Di Cristanziano V, Hüsgen L, Kocyigit C, Rupp J, Sierra S. Accurate HCV genotyping and selection of optimal therapy: lessons from a St. Petersburg strain infection. Clin Microbiol Infect. 2018 Apr;24(4):440-441.

 Frey A, Piras-Straub K, Walker A, Timm J, Gerken G, Herzer K.The influence of immunosuppressants on direct-acting antiviral therapy is dependent on hepatitis C virus genotype. Transpl Infect Dis. 2018 Feb;20(1). doi: 10.1111/tid.12803.

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