Publikationen

2015

Kluth M, Stindt J, Dröge C, Linnemann D, Kubitz R, Schmitt L. (2015) A mutation within the extended X loop abolished substrate-induced ATPase activity of the human liver ATP-binding cassette (ABC) transporter MDR3. J Biol Chem. 290(8): 4896-4907

Kubitz R, Dröge C, Kluge S, Stross C, Walter N, Keitel V, Häussinger D, Stindt J. (2015) Autoimmune BSEP disease: disease recurrence after liver transplantation for progressive familial intrahepatic cholestasis. Clin Rev Allergy Immunol. 2015 Jun;48(2-3):273-84.

Stindt J, Kluge S, Dröge C, Keitel V, Stross C, Baumann U, Brinkert F, Dhawan A, Engelmann G, Ganschow R, Gerner P, Grabhorn E, Knisely AS, Noli KA, Pukite I, Shepherd RW, Ueno T, Schmitt L, Wiek C, Hanenberg H, Häussinger D, Kubitz R. (2015) Bile Salt Export Pump-reactive Antibodies Form a Polyclonal, Multi-inhibitory Response in Antibody-induced BSEP Deficiency. Hepatology. 2015 Oct 30. doi: 10.1002/hep.28311. [Epub ahead of print]

 

2014

Spomer L, Gertzen CG, Schmitz B, Häussinger D, Gohlke H and Keitel V. (2014) A Membrane-proximal, C-terminal alpha-Helix Is Required for Plasma Membrane Localization and Function of the G Protein-coupled Receptor (GPCR) TGR5. J Biol Chem 289 (6): 3689-3702

Kubitz R, Dröge C, Kluge S, Stindt J and Häussinger D. (2014) Genetic variations of bile salt transporters. Drug Dicov Today Technol http://dx.doi.org/10.1016/j.ddtec.2014.03.006

Lang E, Gatidis S, Freise NF, Bock H, Kubitz R, Lauermann C, Orth HM, Klindt C, Schuier M, Keitel V, Reich M, Liu G, Schmidt S, Xu HC, Qadri SM, Herebian D, Pandyra AA, Mayatepek E, Gulbins E, Lang F, Häussinger D, Lang KS, Föller M, Lang PA. (2014) Conjugated bilirubin triggers anemia by inducing erythrocyte death. Hepatology 61(1): 275-84.

 

2013

M. Donner, S. A. Topp, P. Cebula, A. Krienen, T. Gehrmann, A. Sommerfeld, R. Reinehr, A. Macher, D. Herebian, E. Mayatepek, B. H. Pannen, W. T. Knoefel and D. Häussinger (2013) HbG200-mediated preinduction of heme oxygenase-1 improves bile flow and ameliorates pericentral downregulation of Bsep and Mrp2 following experimental liver ischemia and reperfusion. Biol Chem. 394(1): 97-112

P. Ellinger, M. Kluth, J. Stindt, S. H. Smits and L. Schmitt (2013) Detergent Screening and Purification of the Human Liver ABC Transporters BSEP (ABCB11) and MDR3 (ABCB4) Expressed in the Yeast Pichia pastoris. PLoS ONE. 8(4): e60620

N. Infed, S. H. Smits, T. Dittrich, M. Braun, A. J. Driessen, N. Hanekop and L. Schmitt (2013) Analysis of the inhibition potential of zosuquidar derivatives on selected bacterial and fungal ABC transporters. Mol Membr Biol 30(2): 217-227

L. Hoffmann, G. Brauers, T. Gehrmann, D. Häussinger, E. Mayatepek, F. Schliess and B. C. Schwahn (2013) Osmotic regulation of hepatic betaine metabolism. Am J Physiol Gastrointest Liver Physiol 304(9): G835-846

V. Keitel and D. Häussinger (2013) TGR5 in cholangiocytes. Curr Opin Gastroenterol 29 (3): 299-304

V. Keitel, L. Spomer, J. J. Marin, C. Williamson, V. Geenes, R. Kubitz, D. Häussinger and R. I. Macias (2013) Effect of maternal cholestasis on TGR5 expression in human and rat placenta at term. Placenta 34 (9): 810-816

S. Kluge, C. Dröge, D. Häussinger and Kubitz R (2013) Seventy-four mutations in children with Progressive Familial Intrahepatic Cholestasis type 1, 2 or 3. Hepatology ; 58, S1: 1054A, 1760, Supplement: The 64th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2013.

P. Kueppers, R. P. Gupta, J. Stindt, S. H. Smits and L. Schmitt (2013) Functional Impact of a Single Mutation within the Transmembrane Domain of the Multidrug ABC Transporter Pdr5. Biochemistry. 52(13): 2184-2195

J. Stindt, P. Ellinger, K. Weissenberger, C. Dröge, D. Herebian, E. Mayatepek, B. Homey, S. Braun, J. Schulte Am Esch, M. Horacek, A. Canbay, L. Schmitt, D. Häussinger and R. Kubitz (2013) A novel mutation within a transmembrane helix of the bile salt export pump (BSEP, ABCB11) with delayed development of cirrhosis. Liver Int. 33(10): 1527-1535

J. Stindt, S. Kluge, C. Dröge, V. Keitel, G. Engelmann, R. Ganschow, A. Knisely, D. Häussinger and R Kubitz (2013) Acquired BSEP disease due to post-LTX auto-reactive antibody development in PFIC-2 patients. Hepatology;58,S1:564A,750, Supplement: The 64th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2013.

C. Stross, S. Kluge, K. Weissenberger, E. Winands, D. Häussinger and R. Kubitz (2013) A dileucine motif is involved in plasma membrane expression and endocytosis of rat sodium taurocholate cotransporting polypeptide (Ntcp). Am J Physiol Gastrointest Liver Physiol.305(10): G722-730

Haselow K, Bode JG, Wammers M, Ehlting C, Keitel V, Kleinebrecht L, Schupp AK, Häussinger D, Graf D. (2013) Bile acids PKA-dependently induce a switch of the IL-10/IL-12 ratio and reduce proinflammatory capability of human macrophages. J Leukoc Biol. 94(6):1253-64.

 

2012

Bode JG, Ehlting C, Häussinger D. The macrophage response towards LPS and its control through the p38(MAPK)-STAT3 axis. Cell Signal 2012: 24, 1185-94. (PubMed)

C. Dröge, J. Stindt, D. Linnemann, S. Cajani, C. Stross, J. Schulte am Esch, D. Häussinger and R. Kubitz (2012) Expression and targeting of human MDR3-isoforms. Hepatology;56,S1:542A,732, Supplement: The 63rd Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2012.

T. Dzagania, G. Engelmann, D. Häussinger, L. Schmitt, C. Flechtenmacher, I. Rtskhiladze and R. Kubitz (2012) The histidine-loop is essential for transport activity of human MDR3. A novel mutation of MDR3 in a patient with progressive familial intrahepatic cholestasis type 3. Gene 506(1): 141-145

V. Keitel and D. Häussinger (2012) Perspective: TGR5 (Gpbar-1) in liver physiology and disease. Clin Res Hepatol Gastroenterol 36 (5): 412-419

R. Kubitz, C. Dröge, J. Stindt, K. Weissenberger and D. Häussinger (2012) The bile salt export pump (BSEP) in health and disease. Clin Res Hepatol Gastroenterol 36(6): 536-553

Häussinger D, Keitel V, Kubitz R (eds). Hepatobiliary transport in health and disease. De Gruyter, Berlin 2012.

 

2011

Cantore M, Reinehr R, Sommerfeld A, Becker M, Häussinger D. The Src Family Kinase Fyn Mediates Hyperosmolarity-induced Mrp2 and Bsep Retrieval from Canalicular Membrane. J Biol Chem 2011: 286, 45014-45029. (PubMed)

Domanova O, Borbe S, Mühlfeld S, Becker M, Kubitz R, Häussinger D, Berlage T. Toponomics method for the automated quantification of membrane protein translocation.BMC Bioinformatics 2011: 12, 370. (PubMed)

Ehlting C, Ronkina N, Böhmer O, Albrecht U, Bode KA, Lang KS, Kotlyarov A, Radzioch D, Gaestel M, Häussinger D, Bode JG. Distinct functions of the mitogen-activated protein kinase-activated protein (MAPKAP) kinases MK2 and MK3: MK2 mediates lipopolysaccharide-induced signal transducers and activators of transcription 3 (STAT3) activation by preventing negative regulatory effects of MK3. J Biol Chem 2011: 286, 24113-24. (PubMed)

Häussinger D, Reinehr R. Osmotic regulation of bile Acid transport, apoptosis and proliferation in rat liverCell Physiol Biochem 2011: 28, 1089-1098. (PubMed)

Herebian D, Mayatepek E. Inborn errors of bile acid metabolism and their diagnostic confirmation by means of mass spectrometry. Journal of Pediatric Sciences; 2011: 3, e68. (PubMed)

Infed N, Henekop N, Driessen AJ, Smits SH, Schmitt L. Influence of detergents on the activity of the ABC transporter LmrA. Biochim Biophysica Acta 2011; 1808: 2313-2321. (PubMed)

Keitel V, Häussinger D. TGR5 in the biliary tree. Dig Dis 2011: 29, 45-47. (PubMed)

Kubitz R, Bode J, Erhardt A, Graf D, Kircheis G, Müller-Stöver I, Reinehr R, Reuter S, Richter J, Sagir A, Schmitt M, Donner M. Cholestatic liver diseases from child to adult: the diversity of MDR3 disease. Z Gastroenterol 2011: 49, 728-736. (PubMed)

Kubitz R, Brinkmeyer C, Sagir A, Herebian D, Häussinger D. Genetic variants of the bile salt export pump: inducers and modifiers of liver disease. Dig Dis 2011: 29, 89-92. (PubMed)

Stindt J, Ellinger P, Stross C, Keitel V, Häussinger D, Smits SH, Kubitz R, Schmitt L. Heterologous overexpression and mutagenesisof the human bile salt export pump (ABCB11) using DREAM (Directed REcombination-Assosted Mutagenesis)PloS One 2011; 6: e20562 (PubMed)

Thimm E, Herebian D, Assmann B, Klee D, Mayatepek E, Spiekerkoetter U. Increase of CSF tyrosine and impaired serotonin turnover in tyrosinemia type I. Mol Genet Metab 2011: 102, 122-125. (PubMed)

 

2010

Ernst R, Kueppers P, Stindt J, Kuchler K, Schmitt L. Multidrug efflux pumps: substrate selection in ATP-binding cassette multidrug efflux pumps--first come, first served? FEBS J2010;277:540-549. (PubMed)

Graf D, Haselow K, Münks I, Bode JG, Häussinger D. Inhibition of interferon-α-induced signaling by hyperosmolarity and hydrophobic bile acids. Biol Chem 2010: 391, 1175-1187. (PubMed)

Herebian D, Lamshöft M, Mayatepek E, Spiekerkoetter U. Identification of NTBC metabolites in urine from patients with hereditary tyrosinemia type 1 using two different mass spectrometric platforms: triple stage quadrupole and LTQ-Orbitrap. Rapid Commun Mass Spectrom 2010: 24, 791-800. (PubMed)

Hov JR, Keitel V, Laerdahl JK, Spomer L, Ellinghaus E, ElSharawy A, Melum E, Boberg KM, Manke T, Balschun T, Schramm C, Bergquist A, Weismuller T, Gotthardt D, Rust C, Henckaerts L, Onnie CM, Weersma RK, Sterneck M, Teufel A, Runz H, Stiehl A, Ponsioen CY, Wijmenga C, Vatn MH, Stokkers PC, Vermeire S, Mathew CG, Lie BA, Beuers U, Manns MP, Schreiber S, Schrumpf E, Häussinger D, Franke A, Karlsen TH. Mutational characterization of the bile acid receptor TGR5 in primary sclerosing cholangitis. PLoS One2010: 5, e12403. (PubMed)

Keitel V, Ullmer C, Häussinger D. The membrane-bound bile acid receptor TGR5 (Gpbar-1) is localized in the primary cilium of cholangiocytes. Biol Chem 2010: 391, 785-789. (PubMed)

Molojavyi A, Lindecke A, Köhrer K, Gödeck A. Myoglobin-deficient mice activate a discriminative cardiac gene expression program in response to isoproterenol-induced heart failure. Physiol Genomics 2010: 41, 137-145. (PubMed)

Stross C, Helmer A, Weissenberger K, Görg B, Keitel V, Häussinger D, Kubitz R. Protein kinase C induces endocytosis of the sodium taurocholate cotransporting polypeptide. Am J Physiol Gastrointest Liver Physiol 2010: 299, G320-G328. (PubMed)

 

2009

Keitel V, Burdelski M, Vojnisek Z, Schmitt L, Häussinger D, Kubitz R. De novo bile salt transporter antibodies as a possible couse of recurrent graft failure after liver transplantation: a novel mechanism of cholestasis. Hepatology 2009: 50, 510-517. (PubMed)

Keitel V, Cupisti K, Ullmer C, Knoefel WT, Kubitz R, Häussinger D. The membrane-bound bile acid receptor TGR5 is localized in the epithelium of human gallbladders. Hepatology 2009: 50, 861-870. (PubMed)

 

2008

Ernst R, Kueppers P, Klein CM, Schwarzmueller T, Kuchler K, Schmitt L. A mutation of the H-loop selectively affects rhodamine transport by the yeast multidrug ABC transporter Pdr5.Proc Natl Acad Sci USA 2008;105:5069-5074. (PubMed)

Graf D, Haselow K, Münks I, Bode JG, Häussinger D. Caspase-mediated cleavage of the signal-transducing IL-6 receptor subunit gp130. Arch Biochem Biophys 2008: 477, 330-338. (PubMed)

Keitel V, Donner M, Winandy S, Kubitz R, Häussinger D. Expression and function of the bile acid receptor TGR5 in Kupffer cells. Biochem Biophys Res Commun 2008: 372, 78-84. (PubMed)

 

2007

Ehlting C, Lai WS, Schaper F, Brenndörfer ED, Matthes RJ, Heinrich PC, Ludwig S, Blackshear PJ, Gaestel M, Häussinger D, Bode JG. Regulation of suppressor of cytokine signaling 3 (SOCS3) mRNA stability by TNF-alpha involves activation of the MKK6/p38MAPK/MK2 cascade. J Immunol 2007: 178, 2813-2826. (PubMed)

Keitel V, Reinehr R, Gatsios P, Rupprecht C, Görg B, Selbach O, Häussinger D, Kubitz R. The G-protein coupled bile salt receptor TGR5 is expressed in liver sinusoidal endothelial cells. Hepatology 2007: 45, 695-704. (PubMed)

Lang PA, Schenck M, Nicolay JP, Becker JU, Kempe DS, Lupescu A, Koka S, Eisele K, Klarl BA, Rübben H, Schmid KW, Mann K, Hildenbrand S, Hefter H, Huber SM, Wieder T, Erhardt A, Häussinger D, Gulbins E, Lang F. Liver cell death and anemia in Wilson disease involve acid sphingomyelinase and ceramide. Nat Med 2007 Feb;13(2):164-70. (PubMed)

Schäfer C, Gehrmann T, Richter L, Keitel V, Köhrer K, Häussinger D, Schliess F. Modulation of gene expression profiles by hyperosmolarity and insulin. Cell Physiol Biochem 2007b: 20, 369-386. (PubMed)

Schäfer C, Hoffmann L, Heldt K, Lornejad-Schäfer MR, Brauers G, Gehrmann T, Garrow TA, Häussinger D, Mayatepek E, Schwahn BC, Schliess F. Osmotic regulation of betaine homocysteine-S-methyltransferase expression in H4IIE rat hepatoma cells. Am J Physiol Gastrointest Liver Physiol 2007a : 292, 1089-1098. (PubMed)

 

2006

Graf D, Kohlmann C, Haselow K, Gehrmann T, Bode JG, Häussinger D. Bile acids inhibit interleukin-6 signaling via gp130 receptor-dependent and-independent pathways in rat liver.Hepatology 2006: 44, 1206-17. (PubMed)

Kubitz R, Keitel V, Scheuring S, Köhrer K, Häussinger D. Benign recurrent intrahepatic cholestasis associated with mutations of the bile salt export pump. J Clin Gastroenterol2006: 40, 171-175. (PubMed)

Lang PA, Beringer O, Nicolay JP, Amon O, Kempe DS, Hermle T, Attanasio P, Akel A, Schäfer R, Friedrich B, Risler T, Baur M, Olbricht CJ, Zimmerhackl LB, Zipfel PF, Wieder T, Lang F. Suicidal death of erythrocytes in recurrent hemolytic uremic syndrome. J Mol Med 2006 May;84(5):378-88. (PubMed)

Lang PA, Huober J, Bachmann C, Kempe DS, Sobiesiak M, Akel A, Niemoeller OM, Dreischer P, Eisele K, Klarl BA, Gulbins E, Lang F, Wiedler T. Stimulation of erythrocyte phosphatidylserine exposure by paclitaxel. Cell Physiol Biochem 2006;18(1-3):151-64. (PubMed)

 

2005

Horn C, Bremer E, Schmitt L. Functional overexpression and in vitro re-association of OpuA, an osmotically regulated ABC-transport complex from Bacillus subtilis. FEBS Lett2005;579:5765-5768. (PubMed)

Keitel V, Burdelski M, Warskulat U, Kühlkamp T, Keppler D, Häussinger D, Kubitz R. Expression and lokalization of hepatobiliary transport proteins in progressive familial intrahepatic cholestasis. Hepatology 2005: 41, 1160-1172. (PubMed)

Lang PA, Kempe DS, Myssina S, Tanneur V, Birka C, Laufer S, Lang F, Wieder T, Huber SM. PGE(2) in the regulation of programmed erythrocyte death. Cell Death Differ 2005 May;12(5):415-28. (PubMed)

Lang PA, Kempe DS, Tanneur V, Eisele K, Klarl BA, Myssina S, Jendrossek V, Ishii S, Shimizu T, Waidmann M, Hessler G, Huber SM, Lang F, Wieder T. Stimulation of erythrocyte ceramide formation by platelet-activating factor. J Cell Sci 2005 Mar 15;118(Pt 6):1233-43. (PubMed)

 

2004

Kubitz R, Sütfels G, Kühlkamp T, Kölling R, Häussinger D. Trafficking of the bile salt export pump from the Golgi to the canalicular membrane is regulated by the p38 MAP Kinase. Gastroenterology 2004: 126, 541-553. (PubMed)

Lang PA, Kaiser S, Myssina S, Birka C, Weinstock C, Northoff H, Wieder T, Lang F, Huber SM. Effect of Vibrio parahaemolyticus haemolysin on human erythrocytes. Cell Microbiol2004 Apr;6(4):391-400. (PubMed)

 

2003

Bode JG, Schweigart J, Kehrmann J, Ehlting C, Schaper F, Heinrich PC, Häussinger D. TNF-alpha induces tyrosine phosphorylation and recruitment of the Src homology protein-tyrosine phosphatase 2 to the gp130 signal-transducing subunit of the IL-6 receptor complex. J Immunol 2003: 171, 257-266. (PubMed)

Lang PA, Kaiser S, Myssina S, Wieder T, Lang F, Huber SM. Role of Ca2+-activated K+ channels in human erythrocyte apoptosis. Am J Physiol Cell Physiol 2003 Dec;285(6):C1553-60. (PubMed)

Myssina S, Huber SM, Birka C, Lang PA, Lang KS, Friedrich B, Risler T, Wieder T, Lang F. Inhibition of erythrocyte cation channels by erythropoietin. J Am Soc Nephrol 2003 Nov;14(11):2750-7. (PubMed)

 

2001

Schmitt M, Kubitz R, Lizun S, Wettstein M, Häussinger D. Regulation of the dynamic localization of the rat Bsep gene-encoded bile salt export pump by anisoosmolarity.Hepatology 2001: 33, 509-518. (PubMed)

 

1999

Bode JG, Nimmesgern A, Schmitz J, Schaper F, Schmitt M, Frisch W, Häussinger D, Heinrich PC, Graeve L. LPS and TNFalpha induce SOCS3 mRNA and inhibit IL-6-induced activation of STAT3 in macrophagesFEBS Lett 1999: 463, 365-370. (PubMed)

 

1997

Kubitz R, D' Urso D, Keppler D, Häussinger D. Osmodependent dynamic localization of the multidrug resistance protein 2 in the rat hepatocyte canalicular membrane. Gastroenterology1997: 113, 1438-1442. (PubMed)

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