The interdisciplinary Working Group for Cardiovascular Flow Simulations applies innovative numerical models to simulate blood flow in the cardiovascular system. A particular focus is set on the effects of different extracorporeal circulation techniques on the aortic blood flow profile and the intraoperative cerebral perfusion as well as the interaction with atherosclerotic plaques in idealized as well as in individualized vessel geometries. Besides in vitrocirculations and human geometries, animal models are also applied.

The optimization of extracorporeal circulation techniques aims at reducing the risk of complications, such as embolic stroke or organ ischemia. Based on improved knowledge on the resulting flow profiles, preoperative planning is facilitated so that the extracorporeal circulation can be modified accordingly.

Team

  • Priv.-Doz. Dr. med. A. Assmann
  • Univ.-Prof. Dr. med. P. Akhyari

Collaborators

  • CFD Lab, Duesseldorf University of Applied Sciences
  • Department of Cardiovascular Engineering, Helmholtz Institute of the RWTH Aachen University & Hospital

Funding

  • Research Commission of the University of Duesseldorf
  • Research Funding of the Duesseldorf University of Applied Sciences
  • Sorin Group Germany

Publications

  • Assmann A, Gül F, Benim AC, Joos F, Akhyari P, Lichtenberg A.
    Dispersive aortic cannulas reduce aortic wall shear stress affecting atherosclerotic plaque embolization.
    Artif Organs. 2015; 39:203-211.
  • Assmann A, Benim AC, Gül F, Lux P, Akhyari P, Boeken U, Joos F, Feindt P, Lichtenberg A.
    Pulsatile extracorporeal circulation during on-pump cardiac surgery enhances aortic wall shear stress.
    J Biomech. 2012; 45:156-163.
  • Assmann A, Benim AC, Gül F, Akhyari P, Lichtenberg A, Feindt P.
    Preoperative risk evaluation by simulating extracorporeal circulation and its impact on aortic blood flow.
    40th Annual Meeting of the GSTCVS, Stuttgart, 2011.
  • Assmann A, Benim AC, Nahavandi A, Schubert D, Lichtenberg A, Feindt P.
    Pulsatile, non-pulsatile, ante- or retrograde aortic blood flow: all the same? A computational fluid dynamics study of different ECC techniques.
    39th Annual Meeting of the GSTCVS, Stuttgart, 2010.
  • Assmann A, Benim AC, Nahavandi A, Turan E, Schubert D, Gams E, Feindt P.
    Aortic blood flow characteristics of different extracorporeal circulation techniques during cardiac surgery – a computational fluid dynamics study.
    IFMBE Proceedings 25/IV, pp. 1604-1607 / World Congress on Medical Physics and Biomedical Engineering, Munich, 2009.
  • Benim AC, Gül F, Assmann A, Akhyari P, Lichtenberg A, Joos F.
    Validation of loss-coefficient based outlet boundary conditions for simulating aortic flow.
    J Mech Med Biol. 2016; 16(1):1650011.
  • Benim AC, Nahavandi A, Assmann A, Schubert D, Feindt P, Suh SH.
    Simulation of blood flow in human aorta with emphasis on outlet boundary conditions.
    Appl Math Model. 2011; 35(7):3175-3188.
  • Benim AC, Gul F, Nahavandi A, Assmann A, Feindt P, Joos F.
    CFD Analysis of Blood Flow in Human Aorta with Experimental Validation.
    7th International Conference on Computational Heat and Mass Transfer, July 18-22, 2011, Istanbul, Turkey.
  • Benim AC, Gul F, Nahavandi A, Assmann A, Feindt P, Joos F.
    Simulation of Blood Flow in Human Aorta for Extracorporeal Circulation.
    7th International Conference on Heat Transfer, Fluid Mechanics and Thermodynamics (HEFAT) 19-21 July, 2010, Antalya, Turkey; 259-264.
  • Benim AC, Gül F, Nahavandi A, Assmann A, Feindt P, Joos F.
    Computational analysis of blood flow in human aorta.
    IJEMFS. 2010; 2(4):233-242.
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