Metabolically induced Cardiovascular Degeneration

Cardiovascular diseases are a serious element in increasing costs in health care systems. The degenerative aortic valve disease is the leading diagnose and a replacement of the valve is often indispensable. Diabetes mellitus is one of the risk factors of the disease and will be in focus of cardiovascular research since its prevalence is rising. The processes taking place in the development and progression of the degenerative aortic valve disease particularly in relation to Diabetes mellitus are still not fully understood yet. Promising candidates are molecules of the extracellular matrix, especially glycosaminoglycans and proteoglycans. Therefore, in our working group we investigate the mechanisms of these processes in vitro with primary cells of heart valve tissue, in vivo in a mouse model and ex vivo in human heart tissue.


  • Dr. rer. nat. Mareike Barth
  • Dr. rer. nat. Jessica Isabel Selig
  • B. Sc. Caroline Küppers
  • Elena Adler
  • Felix Kraft

Awards & Funding

  • Deutsche Forschungsgemeinschaft (DFG) Förderung „Nachwuchsakademie Herzchirurgie“ 2019
  • Auszeichnung als Heine-Frau 2018 für außergewöhnliche Leistungen und soziales Engagement an der Heinrich-Heine-Universität Düsseldorf
  • Dr. Rusche-Projektförderung der Deutschen Stiftung für Herzforschung (DSHF) 2016
  • Anschubförderung durch die Forschungskommission der medizinischen Fakultät der Heinrich-Heine-Universität 2013
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