Forschungsprojekt:
Regeneration nach Läsionen des zentralen Nervensystems

Beteiligte

Regeneration nach Läsionen des zentralen Nervensystems

Dr. rer. nat. Frank Bosse

Molekulare Neurobiologie
Gebäude-Nr. 13.54.R01.81
Straße Moorenstr. 5
Ort 40225 Düsseldorf

Regeneration nach Läsionen des zentralen Nervensystems

Dr. rer. nat. Nicole Brazda

Molekulare Neurobiologie
Gebäude-Nr. 22.22.R01.37
Straße Universitätsstr. 1
Ort 40225 Düsseldorf

Regeneration nach Läsionen des zentralen Nervensystems

Dr. rer. nat. Veronica Estrada

Molekulare Neurobiologie
Gebäude-Nr. 22.22.R01.37
Straße Universitätsstr. 1
Ort 40225 Düsseldorf

Ausgewählte Publikationen:

Vogelaar CF, König B, Krafft S, Estrada V, Brazda N, Ziegler B, Faissner A, Müller HW.Pharmacological Suppression of CNS Scarring by Deferoxamine Reduces Lesion Volume and Increases Regeneration in an In Vitro Model for Astroglial-Fibrotic Scarring and in Rat Spinal Cord Injury In Vivo. PLoS One. 2015 Jul 29;10(7):e0134371. doi: 10.1371/journal.pone.0134371. eCollection 2015. PubMed

Estrada V, Tekinay A, Müller HW.
Neural ECM mimetics. Prog Brain Res. 2014;214:391-413. PubMed

Estrada V, Müller HW.
Spinal cord injury - there is not just one way of treating it. F1000Prime Rep. 2014 Sep 4;6:84. doi: 10.12703/P6-84. eCollection 2014. PubMed

Estrada V, Brazda N, Schmitz C, Heller S, Blazyca H, Martini R, Müller HW.
Long-lasting significant functional improvement in chronic severe spinal cord injury following scar resection and polyethylene glycol implantation. Neurobiol Dis. 2014 Jul;67:165-79. PubMed

Brazda N, Voss C, Estrada V, Lodin H, Weinrich N, Seide K, Müller J, Müller HW.
A mechanical microconnector system for restoration of tissue continuity and long-term drug application into the injured spinal cord. Biomaterials. 2013 Dec;34(38):10056-64. PubMed

Jaerve A, Kruse F, Malik K, Hartung HP, Müller HW
Age-dependent modulation of cortical transcriptomes in spinal cord injury and repair. PLoS One. 2012;7(12):e49812. PubMed

Järve A, Schira J, Müller HW
Concise review: the potential of stromal cell-derived factor 1 and its receptors to promote stem cell functions in spinal cord repair. Stem Cells Transl Med. 2012 Oct;1(10):732-9. PubMed

Järve A, Müller HW
Chemokines in CNS injury and repair. Cell Tissue Res. 2012; 349(1):229-48. PubMed

Müller HW, Sendtner M, Bähr M
Molecular basis of neural repair mechanisms. Cell Tissue Res. 2012; 349(1):1-4. PubMed

Järve A, Bosse F, Müller HW
SDF-1/CXCL12: its role in spinal cord injury. Int. J. Biochem. Cell Biol. 2012; 44(3):352-6. PubMed

Schira J, Gasis M, Estrada V, Hendricks M, Schmitz C, Trapp T, Kruse F, Kögler G, Wernet P, Hartung HP and Müller HW
Significant clinical, neuropathological and behavioural recovery from acute spinal cord trauma by transplantation of a well-defined somatic stem cell from human umbilical cord blood. Brain 2012; 135(2):431-46. PubMed

Kruse F, Bosse F, Vogelaar CF, Brazda N, Küry P, Gasis M and Müller HW
Cortical gene expression in spinal cord injury and repair: insight into the functional complexity of the neural regeneration program Front Mol Neurosci. 2011; 4:26. PubMed

Järve A, Schiwy N, Schmitz C and Müller HW
Differential effect of aging on axon sprouting and regenerative growth in spinal cord injury. Exp Neurol. 2011; 231, 284-294. PubMed

Schiwy N, Brazda N and Müller HW
Enhanced regenerative axon growth of multiple fibre populations in traumatic spinal cord injury following scar-suppressing treatment. Eur J Neurosci. 2009; 30(8), 1544-53. PubMed

Opatz J, Küry P, Schiwy N, Järve A, Estrada V, Brazda N, Bosse F and Müller HW
SDF-1 stimulates neurite growth on inhibitory CNS myelin. Mol. Cell. Neurosci. 2009; 40(2), 293-300. PubMed

Brazda N and Müller HW
Pharmacological modification of the extracellular matrix to promote regeneration of the injured brain and spinal cord. Prog. Brain Res. 2009; 175, 269-281. PubMed

Greschat S, Schira J, Küry P, Rosenbaum C, de Souza Silva MA, Kögler G, Wernet P and  Müller HW
Unrestricted somatic stem cells from human umbilical cord blood can be differentiated into neurons with a dopaminergic phenotype. Stem Cells Dev. 2008; 17(2), 221-232. PubMed

Müller HW (Ed.)
Neural Degeneration and Repair - Gene Expression Profiling, Proteomics and Systems Biology, WILEY-VCH Verlag, Weinheim 2008. Willey-VCH

Kruse F, Brazda N, Küry P, Bosse F and Müller HW
Analysing complex gene expression profiles in sensorimotor cortex following spinal cord injury and regeneration promoting treatment (in: Neural Degeneration and Repair - Gene Expression Profiling, Proteomics and Systems Biology, ed. H.W. Müller), 2008; pp. 61-89, WILEY-VCH, Weinheim. Willey-VCH

Klapka N and Müller HW
Collagen matrix in spinal cord injury. J. Neurotrauma 2006; 23(3-4), 422-435. PubMed

Hermanns S, Klapka N, Gasis M and Müller HW
The collagenous wound healing scar in the injured central nervous system inhibits axonal regeneration. Brain Repair (ed. M. Bähr), 2006; Springer, Berlin, Heidelberg, 177-190, ISBN 978-0-306-47859-8. Springer

Klapka N, Hermanns S, Straten G, Masanneck C, Duis S, Hamers F, Müller D, Zuschratter W and Müller HW
Suppression of fibrous scarring in spinal cord injury of rat promotes long-distance regeneration of corticospinal tract axons, rescue of primary motoneurons in somatosensory cortex and significant functional recovery. Eur. J. Neurosci. 2005; 22(12), 3047-3058. PubMed

Kögler G, Sensken S, Airey JA, Trapp T, Müschen M, Feldhahn N, Liedtke S, Sorg RV, Fischer J, Rosenbaum C, Greschat S, Knipper A, Bender J, Degistirici O, Gao J, Caplan AI, Colletti EJ, Almeida-Porada G, Müller HW, Zanjani E and Wernet P
A new human somatic stem cell from placental cord blood with intrinsic pluripotent differentiation potential. J. Exp. Med. 2004; 200(2), 123-135. PubMed

Küry P, Abankwa D, Kruse F and Müller HW
Gene expression profiling reveals multiple novel intrinsic and extrinsic factors associated with axonal regeneration failure. Eur. J. Neuroscience 2004; 19(1), 32-42. PubMed

Küry P, Köller H, Hamacher M, Cornely C, Hasse B and Müller HW
Cyclic AMP and tumor necrosis factor- alpha regulate CXCR4 gene expression in Schwann cells. Mol. Cell. Neurosci. 2003; 24(1), 1-9. PubMed

Klapka N, Hermanns S and Müller HW
Interactions between glia and extracellular matrix and their role for axonale Growth. Glial Interfaces in the Nervous System - Role in Repair and Plasticity (H. Aldskogius and J. Fraher, eds.), 2001; IOS Press Amsterdam, pp. 139-151, ISBN 978-1-58603-199-2. IOS Press

Hermanns S, Reiprich P and Müller HW
A reliable method to reduce collagen scar formation in the lesioned rat spinal cord. J. Neurosci. Methods 2001; 110(1-2), 141-146. PubMed

Hermanns S and Müller HW
Preservation and detection of lesion-induced collagenous scar in the CNS depend on the method of tissue processing. Brain Res. Protocols 2001; 7(2), 162-167. PubMed

Hermanns S, Klapka N and Müller HW
The collagenous lesion scar - an obstacle for axonal regeneration in brain and spinal cord injury. Restor. Neurol. Neurosci. 2001; 19(1-2), 139-148. PubMed

Gleichmann M, Gillen C, Czardybon M, Bosse F, Greiner-Petter R, Auer J and Müller HW
Cloning and characterization of SDF-1 , a novel SDF-1 chemokine transcript with developmentally regulated expression in the nervous system. Eur. J. Neurosci. 2000; 12(6), 1857-1866. PubMed

Stichel CC, Hermanns S, Lausberg F and Müller HW
Effects of Schwann cell suspension grafts on axon regeneration in subacute and chronic CNS traumatic injuries. Glia 1999; 28(2), 156-165. PubMed

Stichel CC, Hermanns S, Luhmann HJ, Lausberg F, Niermann H, D´Urso D, Servos G, Hartwig HG and Müller HW
Inhibition of collagen IV deposition promotes regeneration of injured CNS axons. Eur. J. Neurosci. 1999; 11(2), 632-647. PubMed

Stichel CC, Niermann H, D´Urso D, Lausberg F, Hermanns S and Müller HW
Basal membrane-depleted scar in lesioned CNS: characteristics and relationships to regenerating axons. Neurosci. 1999; 93(1), 321-333. PubMed

Stichel CC, Lausberg F, Hermanns S and Müller HW
Scar modulation in subacute and chronic CNS lesions: effects on axonal regeneration. Restor. Neurol. Neurosci. 1999; 15(1), 1-15. PubMed

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