Ausgewählte Publikationen zu Bauchtumoren

Reply to Letter: "Infusion of CD133+ Bone Marrow-derived Stem Cell After Selective Portal Vein Embolization Enhances Functional Hepatic Reserves After Extended Right Hepatectomy".
Am Esch JS, Schmelzle M, Duhme C, Fuerst G, Robson SC, Bode JG, Krieg A, Topp SA, Haeussinger D, Knoefel WT
Ann Surg. 2015 Apr 17

Adaptation of hepatic mitochondrial function in humans with non-alcoholic fatty liver is lost in steatohepatitis.
Koliaki C, Szendroedi J, Kaul K, Jelenik T, Nowotny P, Jankowiak F, Herder C, Carstensen M, Krausch M, Knoefel WT, Schlensak M, Roden M.
Cell Metab. 2015 May 5;21(5):739-46

Metastasized pancreatic carcinoma with neoadjuvant FOLFIRINOX therapy and R0 resection.
Schneitler S, Kröpil P, Riemer J, Antoch G, Knoefel WT, Häussinger D, Graf D.
World J Gastroenterol. 2015 May 28;21(20):6384-90

CXCR4--A Prognostic and Clinicopathological Biomarker for Pancreatic Ductal Adenocarcinoma: A Meta-Analysis.
Krieg A, Riemer JC, Telan LA, Gabbert HE, Knoefel WT.
PLoS One. 2015 Jun 19;10(6):e0130192

Transient Elastography for the Detection of Liver Damage in Patients with HIV.
Sagir A, Glaubach B, Sahin K, Graf D, Erhardt A, Oette M, Häussinger D.
Infect Dis Ther. 2015 Jul 5

Serum microRNA profiles as prognostic/predictive markers in the multimodality therapy of locally advanced adenocarcinomas of the gastroesophageal junction.
Odenthal M, Hee J, Gockel I, Sisic L, Schmitz J, Stoecklein NH, Driemel C, Möhlendick B, Schmidt T, Knoefel WT, Lang H, Büttner R, Ott K, Vallböhmer D. 
Int J Cancer. 2015 Jul 1;137(1):230-7.

Bile acids and stellate cells.
Kordes C, Sawitza I, Götze S, Häussinger D.
Dig Dis. 2015;33(3):332-7.

Epigenetic Changes during Hepatic Stellate Cell Activation.
Götze S, Schumacher EC, Kordes C, Häussinger D.
PLoS One. 2015 Jun 12;10(6):e0128745

IFN-γ licenses CD11b(+) cells to induce progression of systemic lupus erythematosus.
Shaabani N, Honke N, Dolff S, Görg B, Khairnar V, Merches K, Duhan V, Metzger S, Recher M, Barthuber C, Hardt C, Proksch P, Häussinger D, Witzke O, Lang PA, Lang KS.
J Autoimmun. 2015 Aug;62:11-21

Helicobacter pylori Coinfection Is Associated With Decreased Markers of Immune Activation in ART-Naive HIV-Positive and in HIV-Negative Individuals in Ghana.
Eberhardt KA, Sarfo FS, Dompreh A, Kuffour EO, Geldmacher C, Soltau M, Schachscheider M, Drexler JF, Eis-Hübinger AM, Häussinger D, Bedu-Addo G, Phillips RO, Norman B, Burchard GD, Feldt T.
Clin Infect Dis. 2015 Jul 20

Hyperosmotic stress activates the expression of members of the miR-15/107 family and induces downregulation of anti-apoptotic genes in rat liver.
Santosa D, Castoldi M, Paluschinski M, Sommerfeld A, Häussinger D.
Sci Rep. 2015 Jul 21;5:12292

The Influence of Oxygen on the Proliferative Capacity and Differentiation Potential of Lacrimal Gland-Derived Mesenchymal Stem Cells.
Roth M, Spaniol K, Kordes C, Schwarz S, Mertsch S, Häussinger D, Rotter N, Geerling G, Schrader S.
InvestOphthalmol Vis Sci. 2015 Jul 1;56(8):4741-52.

Serum microRNA profiles as prognostic or predictive markers in the multimodality treatment of patients with gastric cancer.
Sisic L, Vallböhmer D, Stoecklein NH, Blank S, Schmidt T, Driemel C, Möhlendick B, Knoefel WT, Odenthal M, Ott K.
Oncol Lett. 2015 Aug;10(2):869-874.

Expression of wingless-type mouse mammary tumor virus integration site family pathway effectors in lymphatic and hepatic metastases of patients with colorectal cancer: Associations with the primary tumor.
Kraus S, Vay C, Baldus S, Knoefel WT, Stoecklein NH, Vallbohmer D. 
Oncol Lett. 2015 Aug;10(2):863-868.

MAPKAP kinase 2 regulates IL-10 expression and prevents formation of intrahepatic myeloid cell aggregates during cytomegalovirus infections.
Ehlting C, Trilling M, Tiedje C, Le-Trilling VT, Albrecht U, Kluge S, Zimmermann A, Graf D, Gaestel M, Hengel H, Häussinger D, Bode JG. 
J Hepatol. 2016 Feb;64(2):380-9. Epub 2015 Aug 20.

Peritoneal sarcomatosis: site of origin for the establishment of an in vitro and in vivo cell line model to study therapeutic resistance in dedifferentiated liposarcoma. 
Mersch S, Riemer JC, Schlünder PM, Ghadimi MP, Ashmawy H, Möhlendick B, Topp SA, Arent T, Kröpil P, Stoecklein NH, Gabbert HE, Knoefel WT, Krieg A.
Tumour Biol. 2015 Sep 15.

TGR5 is essential for bile acid-dependent cholangiocyte proliferation in vivo and in vitro
Reich M, Deutschmann K, Sommerfeld A, Klindt C, Kluge S, Kubitz R, Ullmer C, Knoefel WT, Herebian D, Mayatepek E, Häussinger D, Keitel V. 
Gut. 2016 Mar;65(3):487-501. Epub 2015 Sep 29. 

Syndromic versus non-syndromic sporadic gastrin-producing neuroendocrine tumors of the duodenum: comparison of pathological features and biological behavior.
Rosentraeger MJ, Garbrecht N, Anlauf M, Raffel A, Knoefel WT, Wiedenmann B, Klöppel G. 
Virchows Arch. 2015 Dec 9.

Genetic variants in adult liver diseases. 
Dröge C, Häussinger D, Keitel V. 
Z Gastroenterol. 2015 Dec;53(12):1436-1446. Epub 2015 Dec 14.

Beyond fibrosis: stellate cells as liver stem cells.
Kordes C, Sawitza I, Götze S, Schumacher E, Häussinger D. 
Z Gastroenterol. 2015 Dec;53(12):1425-1431. Epub 2015 Dec 14.

[Prognostic Value of Preoperative Anaemia and Perioperative Blood Transfusion in Surgical Treatment of Rectal Cancer].
Kröpil F, Nestler T, Toeruen M, Fluegen G, Kraus S, Krieg A, Rehders A, Vallböhmer D, Knoefel WT.
Zentralbl Chir. 2015 Dec;140(6):640-4.

Ausgewählte Publikationen zu Brustkrebs

Noninvasive real-time visualization of multiple cerebral hemodynamic parameters in whole mouse brains using five-dimensional optoacoustic tomography.
Gottschalk S, Fehm TF, Deán-Ben XL, Razansky D.
J Cereb Blood Flow Metab. 2015 Mar 31;35(4):531-5.

Significance of apoptotic and non-apoptotic disseminated tumor cells in the bone marrow of patients with clinically localized prostate cancer.
Todenhöfer T, Hennenlotter J, Faber F, Wallwiener D, Schilling D, Kühs U, Aufderklamm S, Bier S, Mischinger J, Gakis G, Fehm T, Stenzl A, Schwentner C.
Prostate. 2015 May;75(6):637-45.

Biomarkers in Patients with Metastatic Breast Cancer and the PRAEGNANT Study Network.
Fasching PA, Brucker SY, Fehm TN, Overkamp F, Janni W, Wallwiener M, Hadji P, Belleville E, Häberle L, Taran FA, Lüftner D, Lux MP, Ettl J, Müller V, Tesch H, Wallwiener D, Schneeweiss A.
Geburtshilfe Frauenheilkd. 2015 Jan;75(1):41-50.

Simultaneous Detection of Disseminated and Circulating Tumor Cells in Primary Breast Cancer Patients.
Hartkopf AD, Wallwiener M, Hahn M, Fehm TN, Brucker SY, Taran FA.
Cancer Res Treat. 2015 Feb 16

Suppression of early hematogenous dissemination of human breast cancer cells to bone marrow by retinoic Acid-induced 2.
Werner S, Brors B, Eick J, Marques E, Pogenberg V, Parret A, Kemming D, Wood AW, Edgren H, Neubauer H, Streichert T, Riethdorf S, Bedi U, Baccelli I, Jücker M, Eils R, Fehm T, Trumpp A, Johnsen SA, Klefström J, Wilmanns M, Müller V, Pantel K, Wikman H.
Cancer Discov. 2015 May;5(5):506-19.

Disseminated tumor cells from the bone marrow of patients with nonmetastatic primary breast cancer are predictive of locoregional relapse.
Hartkopf AD, Wallwiener M, Fehm TN, Hahn M, Walter CB, Gruber I, Brucker SY, Taran FA.
Ann Oncol. 2015 Jun;26(6):1155-60.

Prognostic Relevance of Circulating Tumor Cells in Molecular Subtypes of Breast Cancer.
Banys-Paluchowski M, Schneck H, Blassl C, Schultz S, Meier-Stiegen F, Niederacher D, Krawczyk N, Ruckhaeberle E, Fehm T, Neubauer H.
Geburtshilfe Frauenheilkd. 2015 Mar;75(3):232-237.

Volumetric hand-held optoacoustic angiography as a tool for real-time screening of dense breast.
Deán-Ben XL, Fehm TF, Gostic M, Razansky D.
J Biophotonics. 2015 May 12.

The Value of Serum CA125 in the Diagnosis of Borderline Tumors of the Ovary: A Subanalysis of the Prospective Multicenter ROBOT Study.
Fotopoulou C, Sehouli J, Ewald-Riegler N, de Gregorio N, Reuss A, Richter R, Mahner S, Kommoss F, Schmalfeldt B, Fehm T, Hanker L, Wimberger P, Canzler U, Pfisterer J, Kommoss S, Hauptmann S, du Bois A; ROBOT investigators.
Int J Gynecol Cancer. 2015 May 14.

Acute hepatitis C virus infection induces anti-host cell receptor antibodies with virus-neutralizing properties.
Tawar RG, Colpitts CC, Timm J, Fehm T, Roggendorf M, Meisel H, Meyer N, Habersetzer F, Cosset FL, Berg T, Zeisel MB, Baumert TF.
Hepatology. 2015 May 23.

Detection and prevalence of disseminated tumor cells from the bone marrow of early stage male breast cancer patients.
Hartkopf AD, Taran FA, Walter CB, Hahn M, Fehm T, Wallwiener M, Brucker SY.
Breast Cancer Res Treat. 2015 Jul;152(1):51-5

Genetic variants in VEGF pathway genes in neoadjuvant breast cancer patients receiving bevacizumab: Results from the randomized phase 3 GeparQuinto study.
Hein A, Lambrechts D, von Minckwitz G, Häberle L, Eidtmann H, Tesch H, Untch M, Hilfrich J, Schem C, Rezai M, Gerber B, Dan Costa S, Blohmer JU, Schwedler K, Kittel K, Fehm T, Kunz G, Beckmann MW, Ekici AB, Hanusch C, Huober J, Liedtke C, Mau C, Moisse M, Müller V, Nekljudova V, Peuteman G, Rack B, Rübner M, Van Brussel T, Wang L, Weinshilboum RM, Loibl S, Fasching PA.
Int J Cancer. 2015 Jun 23.

Primary Therapy of Patients with Early Breast Cancer: Evidence, Controversies, Consensus: Opinions of German Specialists to the 14th St. Gallen International Breast Cancer Conference 2015 (Vienna 2015).
Untch M, Harbeck N, Huober J, von Minckwitz G, Gerber B, Kreipe HH, Liedtke C, Marschner N, Möbus V, Scheithauer H, Schneeweiss A, Thomssen C, Jackisch C, Beckmann MW, Blohmer JU, Costa SD, Decker T, Diel I, Fasching PA, Fehm T, Janni W, Lück HJ, Maass N, Scharl A, Loibl S.
Geburtshilfe Frauenheilkd. 2015 Jun;75(6):556-565

Hormone Therapy and its Effect on the Prognosis in Breast Cancer Patients.
Rauh C, Schuetz F, Rack B, Stickeler E, Klar M, Orlowska-Volk M, Windfuhr-Blum M, Heil J, Rom J, Sohn C, Andergassen U, Jueckstock J, Fehm T, Loehberg CR, Hein A, Schulz-Wendtland R, Hartmann A, Beckmann MW, Janni W, Fasching PA, Häberle L.
Geburtshilfe Frauenheilkd. 2015 Jun;75(6):588-596.

Doxycycline Inducible Melanogenic Vaccinia Virus as Theranostic Anti-Cancer Agent.
Kirscher L, Deán-Ben XL, Scadeng M, Zaremba A, Zhang Q, Kober C, Fehm TF, Razansky D, Ntziachristos V, Stritzker J, Szalay AA.
Theranostics. 2015 Jun 15;5(10):1045-57.

[Documentation Time and Effort and Associated Resources for Patients with Primary Breast Cancer from Diagnosis to End of Follow-Up - Results of a Multicentre Validation].
Beckmann M, Sell C, Aydogdu M, Brucker SY, Fehm T, Janni W, Kreienberg R, Kümmel S, Neumann M, Scharl A, Schleicher B, Wallwiener D, Wöckel A, Fasching PA, Lux MP.
Gesundheitswesen. 2015 Aug 6

Exometabolom analysis of breast cancer cell lines: Metabolic signature. 
Willmann L, Erbes T, Halbach S, Brummer T, Jäger M, Hirschfeld M, Fehm T, Neubauer H, Stickeler E, Kammerer B. 
Sci Rep. 2015 Aug 21;5:13374.

May progesterone receptor membrane component 1 (PGRMC1) predict the risk of breast cancer? 
Zhang Y, Ruan X, Willibald M, Seeger H, Fehm T, Neubauer H, Mueck AO. 
Gynecol Endocrinol. 2016 Jan;32(1):58-60. Epub 2015 Aug 24.

Therapeutic intervention based on circulating tumor cell phenotype in metastatic breast cancer: concept of the DETECT study program.
Schramm A, Friedl TW, Schochter F, Scholz C, de Gregorio N, Huober J, Rack B, Trapp E, Alunni-Fabbroni M, Müller V, Schneeweiss A, Pantel K, Meier-Stiegen F, Hartkopf A, Taran FA, Wallwiener D, Janni W, Fehm T. 
Arch Gynecol Obstet. 2016 Feb;293(2):271-81. Epub 2015 Sep 9.

Adjuvant bisphosphonate treatment in early breast cancer: meta-analyses of individual patient data from randomised trials. 
Early Breast Cancer Trialists' Collaborative Group (EBCTCG), Coleman R, Powles T, Paterson A, Gnant M, Anderson S, Diel I, Gralow J, von Minckwitz G,Moebus V, Bergh J, Pritchard KI, Bliss J, Cameron D, Evans V, Pan H, Peto R, Bradley R, Gray R. 
Lancet. 2015 Oct 3;386(10001):1353-61.

Aromatase inhibitors versus tamoxifen in early breast cancer: patient-level meta-analysis of the randomised trials.
Early Breast Cancer Trialists' Collaborative Group (EBCTCG), Dowsett M, Forbes JF, Bradley R, Ingle J, Aihara T, Bliss J, Boccardo F, Coates A, Coombes RC, Cuzick J, Dubsky P, Gnant M, Kaufmann M, Kilburn L, Perrone F, Rea D, Thürlimann B, van de Velde C, Pan H, Peto R, Davies C, Gray R.
Lancet. 2015 Oct 3;386(10001):1341-52. 

Circulating tumor cells in breast cancer-current status and perspectives.
Banys-Paluchowski M, Krawczyk N, Meier-Stiegen F, Fehm T. 
Crit Rev Oncol Hematol. 2016 Jan;97:22-9. Epub 2015 Oct 31.

Adjuvant radiation therapy of regional lymph nodes in breast cancer - a meta-analysis of randomized trials- an update. 
Budach W, Bölke E, Kammers K, Gerber PA, Nestle-Krämling C, Matuschek C. 
Radiat Oncol. 2015 Dec 21;10(1):258. 

Molecular and functional interactions between AKT and SOX2 in breast carcinoma.
Schaefer T, Wang H, Mir P, Konantz M, Pereboom TC, Paczulla AM, Merz B, Fehm T, Perner S, Rothfuss OC, Kanz L, Schulze-Osthoff K, Lengerke C. 
Oncotarget. 2015 Dec 22;6(41):43540-56.

Ausgewählte Publikationen zu Endokrinen Tumoren

PRKACA mutations in cortisol-producing adenomas and adrenal hyperplasia: a single-center study of 60 cases.
Thiel A, Reis AC, Haase M, Goh G, Schott M, Willenberg HS, Scholl UI.
Eur J Endocrinol. 2015 Jun;172(6):677-85
Frequency and clinical correlates of somatic Ying Yang 1 mutations in sporadic insulinomas.
Lichtenauer UD, Di Dalmazi G, Slater EP, Wieland T, Kuebart A, Schmittfull A, Schwarzmayr T, Diener S, Wiese D, Thasler WE, Reincke M, Meitinger T, Schott M, Fassnacht M, Bartsch DK, Strom TM, Beuschlein F.
J Clin Endocrinol Metab. 2015 May;100(5):E776-82.

9B.01: CLINICAL SIGNIFICANCE OF CONTRALATERAL ADRENAL SUPPRESSION DURING ADRENAL VEIN SAMPLING IN PRIMARY ALDOSTERONISM.
Monticone S, Satoh F, Viola A, Fischer E, Vonend O, Bernini G, Quinkler M, Ronconi V, Morimoto R, Kudo M, Degenhart C, Gao X, Willenberg HS, Riester A, Maccario M, Giacchetti G, Veglio F, Ito S, Reincke M, Mulatero P.
J Hypertens. 2015 Jun;33 Suppl
Novel somatic mutations and distinct molecular signature in aldosterone-producing adenomas.
Åkerström T, Willenberg HS, Cupisti K, Ip J, Backman S, Moser A, Maharjan R, Robinson B, Iwen KA, Dralle H, D Volpe C, Bäckdahl M, Botling J, Stålberg P, Westin G, Walz MK, Lehnert H, Sidhu S, Zedenius J, Björklund P, Hellman P.
Endocr Relat Cancer. 2015 Oct;22(5):735-44.

Pregnancy in Women Previously Treated for an Adrenocortical Carcinoma. 
de Corbière P, Ritzel K, Cazabat L, Ropers J, Schott M, Libé R, Koschker AC, Leboulleux S, Deutschbein T, Do Cao C, Hahner S, Drui D, Miehle K, Caron P, Waldmann J, Chabre O, Quinkler M, Touraine P, Villares Fragoso MC, Bertherat J, Bertagna X, Fassnacht M, Raffin-Sanson ML.
J Clin Endocrinol Metab. 2015 Dec;100(12):4604-11.

Cervical compression due to benign thyroid disorders is not associated with increased postoperative morbidity.
Ambe P, Lindecke K, Knoefel WT, Rehders A. 
Eur Arch Otorhinolaryngol. 2015 Sep;272(9):2457-61.

Ausgewählte Publikationen zu Gynäkologischen Tumoren

Decidualization and syndecan-1 knock down sensitize endometrial stromal cells to apoptosis induced by embryonic stimuli.
Boeddeker SJ, Baston-Buest DM, Fehm T, Kruessel J, Hess A.
PLoS One. 2015 Apr 1;10(4):e0121103

Xenotransplantation of cryopreserved human ovarian tissue--a systematic review of MII oocyte maturation and discussion of it as a realistic option for restoring fertility after cancer treatment.
Dittrich R, Lotz L, Fehm T, Krüssel J, von Wolff M, Toth B, van der Ven H, Schüring AN, Würfel W, Hoffmann I, Beckmann MW.
Fertil Steril. 2015 Jun;103(6):1557-65

Association of type and location of BRCA1 and BRCA2 mutations with risk of breast and ovarian cancer.
Rebbeck TR, Mitra N, Wan F, Sinilnikova OM, Healey S, McGuffog L, Mazoyer S, Chenevix-Trench G, Easton DF, Antoniou AC, Nathanson KL; CIMBA Consortium, Laitman Y, Kushnir A, Paluch-Shimon S, Berger R, Zidan J, Friedman E, Ehrencrona H, Stenmark-Askmalm M, Einbeigi Z, Loman N, Harbst K, Rantala J, Melin B, Huo D, Olopade OI, Seldon J, Ganz PA, Nussbaum RL, Chan SB, Odunsi K, Gayther SA, Domchek SM, Arun BK, Lu KH, Mitchell G, Karlan BY, Walsh C, Lester J, Godwin AK, Pathak H, Ross E, Daly MB, Whittemore AS, John EM, Miron A, Terry MB, Chung WK, Goldgar DE, Buys SS, Janavicius R, Tihomirova L, Tung N, Dorfling CM, van Rensburg EJ, Steele L, Neuhausen SL, Ding YC, Ejlertsen B, Gerdes AM, Hansen Tv, Ramón y Cajal T, Osorio A, Benitez J, Godino J, Tejada MI, Duran M, Weitzel JN, Bobolis KA, Sand SR, Fontaine A, Savarese A, Pasini B, Peissel B, Bonanni B, Zaffaroni D, Vignolo-Lutati F, Scuvera G, Giannini G, Bernard L, Genuardi M, Radice P, Dolcetti R, Manoukian S, Pensotti V, Gismondi V, Yannoukakos D, Fostira F, Garber J, Torres D, Rashid MU, Hamann U, Peock S, Frost D, Platte R, Evans DG, Eeles R, Davidson R, Eccles D, Cole T, Cook J, Brewer C, Hodgson S, Morrison PJ, Walker L, Porteous ME, Kennedy MJ, Izatt L, Adlard J, Donaldson A, Ellis S, Sharma P, Schmutzler RK, Wappenschmidt B, Becker A, Rhiem K, Hahnen E, Engel C, Meindl A, Engert S, Ditsch N, Arnold N, Plendl HJ, Mundhenke C, Niederacher D, Fleisch M, Sutter C, Bartram CR, Dikow N, Wang-Gohrke S, Gadzicki D, Steinemann D, Kast K, Beer M, Varon-Mateeva R, Gehrig A, Weber BH, Stoppa-Lyonnet D, Sinilnikova OM, Mazoyer S, Houdayer C, Belotti M, Gauthier-Villars M, Damiola F, Boutry-Kryza N, Lasset C, Sobol H, Peyrat JP, Muller D, Fricker JP, Collonge-Rame MA, Mortemousque I, Nogues C, Rouleau E, Isaacs C, De Paepe A, Poppe B, Claes K, De Leeneer K, Piedmonte M, Rodriguez G, Wakely K, Boggess J, Blank SV, Basil J, Azodi M, Phillips KA, Caldes T, de la Hoya M, Romero A, Nevanlinna H, Aittomäki K, van der Hout AH, Hogervorst FB, Verhoef S, Collée JM, Seynaeve C, Oosterwijk JC, Gille JJ, Wijnen JT, Gómez Garcia EB, Kets CM, Ausems MG, Aalfs CM, Devilee P, Mensenkamp AR, Kwong A, Olah E, Papp J, Diez O, Lazaro C, Darder E, Blanco I, Salinas M, Jakubowska A, Lubinski J, Gronwald J, Jaworska-Bieniek K, Durda K, Sukiennicki G, Huzarski T, Byrski T, Cybulski C, Toloczko-Grabarek A, Złowocka-Perłowska E, Menkiszak J, Arason A, Barkardottir RB, Simard J, Laframboise R, Montagna M, Agata S, Alducci E, Peixoto A, Teixeira MR, Spurdle AB, Lee MH, Park SK, Kim SW, Friebel TM, Couch FJ, Lindor NM, Pankratz VS, Guidugli L, Wang X, Tischkowitz M, Foretova L, Vijai J, Offit K, Robson M, Rau-Murthy R, Kauff N, Fink-Retter A, Singer CF, Rappaport C, Gschwantler-Kaulich D, Pfeiler G, Tea MK, Berger A, Greene MH, Mai PL, Imyanitov EN, Toland AE, Senter L, Bojesen A, Pedersen IS, Skytte AB, Sunde L, Thomassen M, Moeller ST, Kruse TA, Jensen UB, Caligo MA, Aretini P, Teo SH, Selkirk CG, Hulick PJ, Andrulis I.
JAMA. 2015 Apr 7;313(13):1347-61.

An original phylogenetic approach identified mitochondrial haplogroup T1a1 as inversely associated with breast cancer risk in BRCA2 mutation carriers.
Blein S, Bardel C, Danjean V, McGuffog L, Healey S, Barrowdale D, Lee A, Dennis J, Kuchenbaecker KB, Soucy P, Terry MB, Chung WK, Goldgar DE, Buys SS; Breast Cancer Family Registry, Janavicius R, Tihomirova L, Tung N, Dorfling CM, van Rensburg EJ, Neuhausen SL, Ding YC, Gerdes AM, Ejlertsen B, Nielsen FC, Hansen TV, Osorio A, Benitez J, Conejero RA, Segota E, Weitzel JN, Thelander M, Peterlongo P, Radice P, Pensotti V, Dolcetti R, Bonanni B, Peissel B, Zaffaroni D, Scuvera G, Manoukian S, Varesco L, Capone GL, Papi L, Ottini L, Yannoukakos D, Konstantopoulou I, Garber J, Hamann U, Donaldson A, Brady A, Brewer C, Foo C, Evans DG, Frost D, Eccles D; EMBRACE, Douglas F, Cook J, Adlard J, Barwell J, Walker L, Izatt L, Side LE, Kennedy MJ, Tischkowitz M, Rogers MT, Porteous ME, Morrison PJ, Platte R, Eeles R, Davidson R, Hodgson S, Cole T, Godwin AK, Isaacs C, Claes K, De Leeneer K, Meindl A, Gehrig A, Wappenschmidt B, Sutter C, Engel C, Niederacher D, Steinemann D, Plendl H, Kast K, Rhiem K, Ditsch N, Arnold N, Varon-Mateeva R, Schmutzler RK, Preisler-Adams S, Markov NB, Wang-Gohrke S, de Pauw A, Lefol C, Lasset C, Leroux D, Rouleau E, Damiola F; GEMO Study Collaborators, Dreyfus H, Barjhoux L, Golmard L, Uhrhammer N, Bonadona V, Sornin V, Bignon YJ, Carter J, Van Le L, Piedmonte M, DiSilvestro PA, de la Hoya M, Caldes T, Nevanlinna H, Aittomäki K, Jager A, van den Ouweland AM, Kets CM, Aalfs CM, van Leeuwen FE, Hogervorst FB, Meijers-Heijboer HE; HEBON, Oosterwijk JC, van Roozendaal KE, Rookus MA, Devilee P, van der Luijt RB, Olah E, Diez O, Teulé A, Lazaro C, Blanco I, Del Valle J, Jakubowska A, Sukiennicki G, Gronwald J, Lubinski J, Durda K, Jaworska-Bieniek K, Agnarsson BA, Maugard C, Amadori A, Montagna M, Teixeira MR, Spurdle AB, Foulkes W, Olswold C, Lindor NM, Pankratz VS, Szabo CI, Lincoln A, Jacobs L, Corines M, Robson M, Vijai J, Berger A, Fink-Retter A, Singer CF, Rappaport C, Kaulich DG, Pfeiler G, Tea MK, Greene MH, Mai PL, Rennert G, Imyanitov EN, Mulligan AM, Glendon G, Andrulis IL, Tchatchou S, Toland AE, Pedersen IS, Thomassen M, Kruse TA, Jensen UB, Caligo MA, Friedman E, Zidan J, Laitman Y, Lindblom A, Melin B, Arver B, Loman N, Rosenquist R, Olopade OI, Nussbaum RL, Ramus SJ, Nathanson KL, Domchek SM, Rebbeck TR, Arun BK, Mitchell G, Karlan BY, Lester J, Orsulic S, Stoppa-Lyonnet D, Thomas G, Simard J, Couch FJ, Offit K, Easton DF, Chenevix-Trench G, Antoniou AC, Mazoyer S, Phelan CM, Sinilnikova OM, Cox DG.
Breast Cancer Res. 2015 Apr 25;17:61
AluY-mediated germline deletion, duplication and somatic stem cell reversion in UBE2T defines a new subtype of Fanconi anemia.
Virts EL, Jankowska A, Mackay C, Glaas MF, Wiek C, Kelich SL, Lottmann N, Kennedy FM, Marchal C, Lehnert E, Scharf RE, Dufour C, Lanciotti M, Farruggia P, Santoro A, Savasan S, Scheckenbach K, Schipper J, Wagenmann M, Lewis T, Leffak M, Farlow JL, Foroud TM, Honisch E, Niederacher D, Chakraborty SC, Vance GH, Pruss D, Timms KM, Lanchbury JS, Alpi AF, Hanenberg H.
Hum Mol Genet. 2015 Jun 17.

Rapid correction of severe hyponatremia after hysteroscopic surgery – a case report.
Hepp P, Jüttner T, Beyer I, Fehm T, Janni W, Monaca E.
BMC Anesthesiol. 2015 Jun 9;15:85.

Ausgewählte Publikationen zu Hauttumoren

Pathogenicity of POFUT1 in Dowling-Degos disease: additional mutations and clinical overlap with reticulate acropigmentation of kitamura.
Basmanav FB, Fritz G, Lestringant GG, Pachat D, Hoffjan S, Fischer J, Wehner M, Wolf S, Thiele H, Altmüller J, Pulimood SA, Rütten A, Kruse R, Hanneken S, Frank J, Danda S, Bygum A, Betz RC.
J Invest Dermatol. 2015 Feb;135(2):615-8.
Biallelic inactivation of protoporphyrinogen oxidase and hydroxymethylbilane synthase is associated with liver cancer in acute porphyrias.
Schneider-Yin X, van Tuyll van Serooskerken AM, Siegesmund M, Went P, Barman-Aksözen J, Bladergroen RS, Komminoth P, Cloots RH, Winnepenninckx VJ, zur Hausen A, Weber M, Driessen A, Poblete-Gutiérrez P, Bauer P, Schroeder C, van Geel M, Minder EI, Frank J.
J Hepatol. 2015 Mar;62(3):734-8

Occurrence of Malignant Tumours in the Acute Hepatic Porphyrias. 
Lang E, Schäfer M, Schwender H, Neumann NJ, Frank J. 
JIMD Rep. 2015;22:17-22

Identification of a novel mutation in RIPK4 in a kindred with phenotypic features of Bartsocas-Papas and CHAND syndromes.
Gollasch B, Basmanav FB, Nanda A, Fritz G, Mahmoudi H, Thiele H, Wehner M, Wolf S, Altmüller J, Nürnberg P, Frank J, Betz RC.
Am J Med Genet A. 2015 Jun 30
Afamelanotide for Erythropoietic Protoporphyria.
Langendonk JG, Balwani M, Anderson KE, Bonkovsky HL, Anstey AV, Bissell DM, Bloomer J, Edwards C, Neumann NJ, Parker C, Phillips JD, Lim HW, Hamzavi I, Deybach JC, Kauppinen R, Rhodes LE, Frank J, Murphy GM, Karstens FP, Sijbrands EJ, de Rooij FW, Lebwohl M, Naik H, Goding CR, Wilson JH, Desnick RJ.
N Engl J Med. 2015 Jul 2;373(1):48-59

Deficiency in lymphotoxin β receptor protects from atherosclerosis in apoE-deficient mice.
Grandoch M, Feldmann K, Göthert JR, Dick LS, Homann S, Klatt C, Bayer JK, Waldheim JN, Rabausch B, Nagy N, Oberhuber A, Deenen R, Köhrer K, Lehr S, Homey B, Pfeffer K, Fischer JW.
Circ Res. 2015 Apr 10;116(8):e57-68
Dichotomy of short and long thymic stromal lymphopoietin isoforms in inflammatory disorders of the bowel and skin.
Fornasa G, Tsilingiri K, Caprioli F, Botti F, Mapelli M, Meller S, Kislat A, Homey B, Di Sabatino A, Sonzogni A, Viale G, Diaferia G, Gori A, Longhi R, Penna G, Rescigno M.
J Allergy Clin Immunol. 2015 Aug;136(2):413-22
TH17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26.
Meller S, Di Domizio J, Voo KS, Friedrich HC, Chamilos G, Ganguly D, Conrad C, Gregorio J, Le Roy D, Roger T, Ladbury JE, Homey B, Watowich S, Modlin RL, Kontoyiannis DP, Liu YJ, Arold ST, Gilliet M.
Nat Immunol. 2015 Sep;16(9):970-979

Ausgewählte Publikationen zu Hirntumoren

5-ALA-induced fluorescence behavior of reactive tissue changes following glioblastoma treatment with radiation and chemotherapy.
Kamp MA, Felsberg J, Sadat H, Kuzibaev J, Steiger HJ, Rapp M, Reifenberger G, Dibué M, Sabel M.
Acta Neurochir (Wien). 2015 Feb;157(2):207-1

Aminolevulinic acid-mediated photodynamic therapy of human meningioma: an in vitro study on primary cell lines. 
El-Khatib M, Tepe C, Senger B, Dibué-Adjei M, Riemenschneider MJ, Stummer W, Steiger HJ, Cornelius JF. 
Int J Mol Sci. 2015 Apr 30;16(5):9936-48. 

Feasibility of the EORTC/NCIC Trial Protocol in a Neurosurgical Outpatient Unit: The Case for Neurosurgical Neuro-Oncology.
Rapp M, Sadat H, Slotty PJ, Steiger HJ, Budach W, Sabel M.
J Neurol Surg A Cent Eur Neurosurg. 2015 Jul

The use of dynamic O-(2-18F-fluoroethyl)-l-tyrosine PET in the diagnosis of patients with progressive and recurrent glioma.
Galldiks N, Stoffels G, Filss C, Rapp M, Blau T, Tscherpel C, Ceccon G, Dunkl V, Weinzierl M, Stoffel M, Sabel M, Fink GR, Shah NJ, Langen KJ.
Neuro Oncol. 2015 May 24

136 Complete Resection of Contrast-Enhancing Tumor Volume is Associated With Improved Survival in Recurrent Glioblastoma Results From the DIRECTOR Trial.

Suchorska B, Weller M, Tabatabai G, Senft C, Hau P, Sabel M, Herrlinger U, Ketter R, Schlegel U, Marosi C, Reifenberger G, Wick W, Tonn JC, Wirsching HG.
Neurosurgery. 2015 Aug;62 Suppl 1:209

MGMT Promoter Methylation Is a Strong Prognostic Biomarker for Benefit from Dose-Intensified Temozolomide Rechallenge in Progressive Glioblastoma: The DIRECTOR Trial.
Weller M, Tabatabai G, Kästner B, Felsberg J, Steinbach JP, Wick A, Schnell O, Hau P, Herrlinger U, Sabel MC, Wirsching HG, Ketter R, Bähr O, Platten M, Tonn JC, Schlegel U, Marosi C, Goldbrunner R, Stupp R, Homicsko K, Pichler J, Nikkhah G, Meixensberger J, Vajkoczy P, Kollias S, Hüsing J,Reifenberger G, Wick W; DIRECTOR Study Group. 
Clin Cancer Res. 2015 May 1;21(9):2057-64.

Clinical benefit from resection of recurrent glioblastomas: results of a multicenter study including 503 patients with recurrent glioblastomas undergoing surgical resection.
Ringel F, Pape H, Sabel M, Krex D, Bock HC, Misch M, Weyerbrock A, Westermaier T, Senft C, Schucht P, Meyer B, Simon M; SN1 study group.
Neuro Oncol. 2015 Aug 4

Role of microRNAs located on chromosome arm 10q in malignant gliomas.
Wolter M, Werner T, Malzkorn B, Reifenberger G.
Brain Pathol. 2015 Jul 30.

Timing of Mean Transit Time Maximization is Associated with Neurological Outcome After Subarachnoid Hemorrhage.
Caspers J, Rubbert C, Turowski B, Martens D, Reichelt DC, May R, Aissa J, Hänggi D, Etminan N, Mathys C.
Clin Neuroradiol. 2015 May 5
NEWTON: Nimodipine Microparticles to Enhance Recovery While Reducing Toxicity After Subarachnoid Hemorrhage.
Hänggi D, Etminan N, Macdonald RL, Steiger HJ, Mayer SA, Aldrich F, Diringer MN, Hoh BL, Mocco J, Strange P, Faleck HJ, Miller M.
Neurocrit Care. 2015 Feb 13
The influence of decompressive craniectomy for major stroke on early cerebral perfusion.
Slotty PJ, Kamp MA, Beez T, Beenen H, Steiger HJ, Turowski B, Hänggi D.
J Neurosurg. 2015 Jul;123(1):59-64.
Real-time ultrasound guidance for ventricular catheter placement in pediatric cerebrospinal fluid shunts.
Beez T, Sarikaya-Seiwert S, Steiger HJ, Hänggi D.
Childs Nerv Syst. 2015 Feb;31(2):235-41

Somatic CRISPR/Cas9-mediated tumour suppressor disruption enables versatile brain tumour modelling.
Zuckermann M, Hovestadt V, Knobbe-Thomsen CB, Zapatka M, Northcott PA, Schramm K, Belic J, Jones DT, Tschida B, Moriarity B, Largaespada D, Roussel MF, Korshunov A, Reifenberger G, Pfister SM, Lichter P, Kawauchi D, Gronych J. 
Nat Commun. 2015 Jun 11;6:7391. 

Uptake and tracer kinetics of O-(2-(18)F-fluoroethyl)-L-tyrosine in meningiomas: preliminary results.
Cornelius JF, Stoffels G, Filß C, Galldiks N, Slotty P, Kamp M, el Khatib M, Hänggi D, Sabel M, Felsberg J, Steiger HJ, Coenen HH, Shah NJ, Langen KJ.
Eur J Nucl Med Mol Imaging. 2015 Mar;42(3):459-67

In vivo porcine training model for cranial neurosurgery.
Regelsberger J, Eicker S, Siasios I, Hänggi D, Kirsch M, Horn P, Winkler P, Signoretti S, Fountas K, Dufour H, Barcia JA, Sakowitz O, Westermaier T, Sabel M, Heese O.
Neurosurg Rev. 2015 Jan;38(1):157-63

Adult IDH wild type astrocytomas biologically and clinically resolve into other tumor entities. 
Reuss DE, Kratz A, Sahm F, Capper D, Schrimpf D, Koelsche C, Hovestadt V, Bewerunge-Hudler M, Jones DT, Schittenhelm J, Mittelbronn M, Rushing E, Simon M, Westphal M, Unterberg A, Platten M, Paulus W, Reifenberger G, Tonn JC, Aldape K, Pfister SM, Korshunov A, Weller M, Herold-Mende C, Wick W, Brandner S, von Deimling A. 
Acta Neuropathol. 2015 Sep;130(3):407-17.

Early postoperative magnet resonance tomography after resection of cerebral metastases.
Kamp MA, Rapp M, Bühner J, Slotty PJ, Reichelt D, Sadat H, Dibué-Adjei M, Steiger HJ, Turowski B,Sabel M.
Acta Neurochir (Wien). 2015 Sep;157(9):1573-80.

Interferon-β Modulates the Innate Immune Response against Glioblastoma Initiating Cells. 
Wolpert F, Happold C, Reifenberger G, Florea AM, Deenen R, Roth P, Neidert MC, Lamszus K, Westphal M, Weller M, Eisele G. 
PLoS One. 2015 Oct 6;10(10):e0139603. 

Histologically distinct neuroepithelial tumors with histone 3 G34 mutation are molecularly similar and comprise a single nosologic entity.
Korshunov A, Capper D, Reuss D, Schrimpf D, Ryzhova M, Hovestadt V, Sturm D, Meyer J, Jones C, Zheludkova O, Kumirova E, Golanov A, Kool M, Schüller U, Mittelbronn M, Hasselblatt M, Schittenhelm J, Reifenberger G, Herold-Mende C, Lichter P, von Deimling A, Pfister SM, Jones DT. 
Acta Neuropathol. 2015 Oct 19.

Gliomatosis cerebri: no evidence for a separate brain tumor entity. 
Herrlinger U, Jones DT, Glas M, Hattingen E, Gramatzki D, Stuplich M, Felsberg J, Bähr O, Gielen GH, Simon M, Wiewrodt D, Schabet M, Hovestadt V, Capper D, Steinbach JP, von Deimling A, Lichter P, Pfister SM, Weller M, Reifenberger G. 
Acta Neuropathol. 2015 Oct 22.

Chronophin is a glial tumor modifier involved in the regulation of glioblastoma growth and invasiveness. 
Schulze M, Fedorchenko O, Zink TG, Knobbe-Thomsen CB, Kraus S, Schwinn S, Beilhack A, Reifenberger G, Monoranu CM, Sirén AL, Jeanclos E, Gohla A. 
Oncogene. 2015 Nov 9. 

Recurrent spinal metastasis of a sporadic medullary carcinoma of the thyroid after radiation therapy: a case report and review of the literature.
Munoz-Bendix C, Santacroce A, Gierga K, Floeth FW, Steiger HJ, Penalonzo MA, Eicker SO. 
Clin Case Rep. 2015 Nov 9;4(1):9-18.

Ausgewählte Publikationen zu Kopf-Hals-Tumoren

MicroRNA expression in differentially metastasizing tumors of the head and neck: adenoid cystic versus squamous cell carcinoma.
Veit JA, Scheckenbach K, Schuler PJ, Laban S, Wiggenhauser SP, Thierauf J, Klussmann JP, Hoffmann TK.
Anticancer Res. 2015 Mar;35(3):1271-7.

Hyperfractionated accelerated radiation therapy (HART) of 70.6 Gy with concurrent 5-FU/Mitomycin C is superior to HART of 77.6 Gy alone in locally advanced head and neck cancer: long-term results of the ARO 95-06 randomized phase III trial. 
Budach V, Stromberger C, Poettgen C, Baumann M, Budach W, Grabenbauer G, Marnitz S, Olze H, Wernecke KD, Ghadjar P. 
Int J Radiat Oncol Biol Phys. 2015 Apr 1;91(5):916-24. 

A new possibility to assess the perioperative walking capacity using a global positioning system in neurosurgical spine patients: a feasibility study.
Bostelmann R, Schneller S, Cornelius JF, Steiger HJ, Fischer I.
Eur Spine J. 2015 Apr 9. 

Challenges in Histologic Diagnosis of Nonchordomatous Lesions of the Clivus.
Kristin J, Schipper JH, Jalkhi M, Zahnert T, Wagenmann M.
JAMA Otolaryngol Head Neck Surg. 2015 Jun 18
The current state of facial prosthetics - A multicenter analysis.
Thiele OC, Brom J, Dunsche A, Ehrenfeld M, Federspil P, Frerich B, Hölzle F, Klein M, Kreppel M, Kübler AC, Kübler NR, Kunkel M, Kuttenberger J, Lauer G, Mayer B, Mohr C, Neff A, Rasse M, Reich RH, Reinert S, Rothamel D, Sader R, Schliephake H, Schmelzeisen R, Schramm A, Sieg P, Terheyden H, Wiltfang J, Ziegler CM, Mischkowski RA, Zöller JE.
J Craniomaxillofac Surg. 2015 May 15

Analysis of angiogenic markers in oral squamous cell carcinoma-gene and protein expression.
Jung S, Sielker S, Purcz N, Sproll C, Acil Y, Kleinheinz J.
Head Face Med. 2015 Jun 5;11:19

Evaluation of Customized Prosthesis for Irregularly Formed Tracheostoma After Laryngectomy.
Doescher J, Scheckenbach K, Angerstein W, Veit JA, Laban S, Thierauf J, Theodoraki MN, Greve J, Schuler PJ, Hoffmann TK.
Ann Otol Rhinol Laryngol. 2016 Feb;125(2):145-50.  Epub 2015 Aug 25.

Early surgical occipitocervical stabilization for plasma cell neoplasms at the craniocervical junction: systematic review and proposal of a treatment algorithm.
Ahmadi SA, Slotty PJ, Munoz-Bendix C, Steiger HJ, Cornelius JF. 
Spine J. 2016 Jan 1;16(1):91-104. Epub 2015 Sep 26. Review.

A Transtubular Microsurgical Approach to Treat Lateral Cervical Disc Herniation.
Eicker SO, Steiger HJ, El-Kathib M. 
World Neurosurg. 2015 Oct 23. pii: S1878-8750(15)01380-7.

Induction chemotherapy followed by concurrent radio-chemotherapy versus concurrent radio-chemotherapy alone as treatment of locally advanced squamous cell carcinoma of the head and neck (HNSCC): A meta-analysis of randomized trials. 
Budach W, Bölke E, Kammers K, Gerber PA, Orth K, Gripp S, Matuschek C. 
Radiother Oncol. 2015 Nov 14. pii: S0167-8140(15)00563-0. 

Ausgewählte Publikationen zu Leukämien und Lymphomen

Effects of Radiotherapy in the treatment of multiple myeloma: a retrospective analysis of a Single Institution.
Matuschek C, Ochtrop TA, Bölke E, Ganswindt U, Fenk R, Gripp S, Kröpil P, Gerber PA, Kammers K, Hamilton J, Orth K, Budach W. Radiat Oncol. 2015 Mar 28;10:71.

Cellularity, characteristics of hematopoietic parameters and prognosis in myelodysplastic syndromes.
Schemenau J, Baldus S, Anlauf M, Reinecke P, Braunstein S, Blum S, Nachtkamp K, Neukirchen J, Strup C, Aul C, Haas R, Gattermann N, Germing U.
Eur J Haematol. 2015 Sep;95(3):181-9

Treatment of donor-specific antibody-mediated graft rejection by immunochemotherapy, third-party DLI, plasmapheresis and immunoadsorption.
Wilk CM, Fischer JC, Schieren G, Rox JM, Haas R, Rump LC, Kobbe G, Schroeder T.
Bone Marrow Transplant. 2015 Apr;50(4):613-4

Impaired cytotoxicity associated with defective natural killer cell differentiation in myelodysplastic syndromes.
Hejazi M, Manser AR, Fröbel J, Kündgen A, Zhao X, Schönberg K, Germing U, Haas R, Gattermann N, Uhrberg M.
Haematologica. 2015 May;100(5):643-52

Achievement of complete remission predicts outcome of allogeneic haematopoietic stem cell transplantation in patients with chronic myelomonocytic leukaemia. A study of the Chronic Malignancies Working Party of the European Group for Blood and Marrow Transplantation.
Symeonidis A, van Biezen A, de Wreede L, Piciocchi A, Finke J, Beelen D, Bornhäuser M, Cornelissen J, Volin L, Mufti G, Chalandon Y, Ganser A, Bruno B, Niederwieser D, Kobbe G, Schwerdtfeger R, de Witte T, Robin M, Kröger N; Chronic Malignancies Working Party of the European Group for Blood and Marrow Transplantation.
Br J Haematol. 2015 Jul 26. 

Change of prognosis of patients with myelodysplastic syndromes during the last 30 years.
Neukirchen J, Nachtkamp K, Schemenau J, Aul C, Giagounidis A, Strupp C, Kuendgen A, Kobbe G, Haas R, Germing U.
Leuk Res. 2015 Jul;39(7):679-83
Reply to 'Allogeneic hematopoietic cell transplantation for concurrent multiple myeloma and myelodysplastic syndrome'.
Schroeder T, Fenk R, Haas R, Germing U, Kobbe G.
Bone Marrow Transplant. 2015 Aug 3. 
Prognostic value of circulating Bcl-2/IgH levels in patients with follicular lymphoma receiving first-line immuno-chemotherapy.
Zohren F, Bruns I, Pechtel S, Schroeder T, Fenk R, Czibere A, Maschmeyer G, Kofahl-Krause D, Niederle N, Heil G, Losem C, Welslau M, Brugger W, Germing U, Kronenwett R, Barth J, Rummel MJ, Haas R, Kobbe G.
Blood. 2015 Aug 3

Response to erythropoietic-stimulating agents in patients with chronic myelomonocytic leukemia.
Xicoy B, Germing U, Jimenez MJ, Garcia O, Garcia R, Schemenau J, Pedro C, Luño E, Bernal T, González B, Strupp C, Ardanaz M, Kuendgen A, Cedena MT, Neukirchen J, Calabuig M, Brunet S, Medina A, Amigo ML, Ramos F, Callejas M, Díez-Campelo M, Bailén A, Collado R, Vicente A, Arnan M, Valcarcel D, Arilla MJ, Zamora L, Benlloch L, Sanz G.
Eur J Haematol. 2015 Sep 5. 

In patients with myelodysplastic syndromes with del(5q), factors other than age and sex contribute to the prognostic advantage, which diminishes over time.
Lauseker M, Schemenau J, Strupp C, Kündgen A, Gattermann N, Hasford J, Germing U.
Br J Haematol. 2015 Sep;170(5):687-93

Deep serum discoveries: SDF-1α and HSA fragments in myelodysplastic syndromes.
Fröbel J, Hartwig S, Jourdain S, Fischer JC, Zilkens C, Kündgen A, Suckau D, Germing U, Czibere A, Lehr S.
Am J Hematol. 2015 May 25

Validation of the revised international prognostic scoring system (IPSS-R) in patients with lower-risk myelodysplastic syndromes: a report from the prospective European LeukaemiaNet MDS (EUMDS) registry.
de Swart L, Smith A, Johnston TW, Haase D, Droste J, Fenaux P, Symeonidis A, Sanz G, Hellström-Lindberg E, Cermák J, Germing U, Stauder R, Georgescu O, MacKenzie M, Malcovati L, Holm MS, Almeida AM, Mądry K, Slama B, Guerci-Bresler A, Sanhes L, Beyne-Rauzy O, Luño E, Bowen D, de Witte T.
Br J Haematol. 2015 Aug;170(3):372-83

Validation of WHO classification-based Prognostic Scoring System (WPSS) for myelodysplastic syndromes and comparison with the revised International Prognostic Scoring System (IPSS-R). A study of the International Working Group for Prognosis in Myelodysplasia (IWG-PM).
Della Porta MG, Tuechler H, Malcovati L, Schanz J, Sanz G, Garcia-Manero G, Solé F, Bennett JM, Bowen D, Fenaux P, Dreyfus F, Kantarjian H, Kuendgen A, Levis A, Cermak J, Fonatsch C, Le Beau MM, Slovak ML, Krieger O, Luebbert M, Maciejewski J, Magalhaes SM, Miyazaki Y, Pfeilstöcker M, Sekeres MA, Sperr WR, Stauder R, Tauro S, Valent P, Vallespi T, van de Loosdrecht AA, Germing U, Haase D, Greenberg PL, Cazzola M.
Leukemia. 2015 Jul;29(7):1502-13
An international consortium proposal of uniform response criteria for myelodysplastic/myeloproliferative neoplasms (MDS/MPN) in adults.
Savona MR, Malcovati L, Komrokji R, Tiu RV, Mughal TI, Orazi A, Kiladjian JJ, Padron E, Solary E, Tibes R, Itzykson R, Cazzola M, Mesa R, Maciejewski J, Fenaux P, Garcia-Manero G, Gerds A, Sanz G, Niemeyer CM, Cervantes F, Germing U, Cross NC, List AF; MDS/MPN International Working Group.
Blood. 2015 Mar 19;125(12):1857-65

First steps towards successful post-transplant therapy for myeloid malignancies following allogeneic blood stem cell transplantation.
Schroeder T, Kobbe G.
Biol Blood Marrow Transplant. 2015 Aug 12

Telomere dynamics in patients with del (5q) MDS before and under treatment with lenalidomide.
Beier F, Masouleh BK, Buesche G, Ventura Ferreira MS, Schneider RK, Ziegler P, Wilop S, Vankann L, Gattermann N, Platzbecker U, Giagounidis A, Götze KS, Nolte F, Hofmann WK, Haase D, Kreipe H, Panse J, Blasco MA, Germing U, Brümmendorf TH.
Leuk Res. 2015 Sep 21. pii: S0145-2126(15)30380-5. 

Frequency and prognostic impact of casein kinase 1A1 mutations in MDS patients with deletion of chromosome 5q.
Heuser M, Meggendorfer M, Cruz MM, Fabisch J, Klesse S, Köhler L, Göhring G, Ganster C, Shirneshan K, Gutermuth A, Cerny-Reiterer S, Krönke J, Panagiota V, Haferlach C, Koenecke C, Platzbecker U, Thiede C, Schroeder T, Kobbe G, Ehrlich S, Stamer K, Döhner K, Valent P, Schlegelberger B, Kroeger N, Ganser A, Haase D, Haferlach T, Thol F.
Leukemia. 2015 Sep;29(9):1942-5. 

Influence of Di(2-ethylhexyl)phthalate on migration rate and differentiation of human hematopoietic stem and progenitor cells (CD34+).
Manz P, Cadeddu RP, Wilk M, Fischer JC, Fritz B, Haas R, Wenzel F.
Clin Hemorheol Microcirc. 2015;61(2):111-8.

Updated recommendations on the management of gastrointestinal disturbances during iron chelation therapy with Deferasirox in transfusion dependent patients with myelodysplastic syndrome - Emphasis on optimized dosing schedules and new formulations.
Nolte F, Angelucci E, Breccia M, Gattermann N, Santini V, Vey N, Hofmann WK.
Leuk Res. 2015 Oct;39(10):1028-33. 

Ruxolitinib in corticosteroid-refractory graft-versus-host disease after allogeneic stem cell transplantation: a multicenter survey.
Zeiser R, Burchert A, Lengerke C, Verbeek M, Maas-Bauer K, Metzelder SK, Spoerl S, Ditschkowski M, Ecsedi M, Sockel K, Ayuk F, Ajib S, de Fontbrune FS, Na IK, Penter L, Holtick U, Wolf D, Schuler E, Meyer E, Apostolova P, Bertz H, Marks R, Lübbert M, Wäsch R, Scheid C, Stölzel F, Ordemann R, Bug G, Kobbe G, Negrin R, Brune M, Spyridonidis A, Schmitt-Gräff A, van der Velden W, Huls G, Mielke S, Grigoleit GU, Kuball J, Flynn R, Ihorst G, Du J, Blazar BR, Arnold R, Kröger N, Passweg J, Halter J, Socié G, Beelen D, Peschel C, Neubauer A, Finke J, Duyster J, von Bubnoff N.
Leukemia. 2015 Oct;29(10):2062-8. 

Functional inhibition of mesenchymal stromal cells in acute myeloid leukemia.
Geyh S, Rodríguez-Paredes M, Jäger P, Khandanpour C, Cadeddu RP, Gutekunst J, Wilk CM, Fenk R, Zilkens C, Hermsen D, Germing U, Kobbe G, Lyko F, Haas R, Schroeder T.
Leukemia. 2015 Nov 25. 

New insights into transfusion-related iron toxicity: Implications for the oncologist.
Porter JB, de Witte T, Cappellini MD, Gattermann N.
Crit Rev Oncol Hematol. 2015 Nov 27. pii: S1040-8428(15)30088-3.

Decitabine improves progression-free survival in older high-risk MDS patients with multiple autosomal monosomies: results of a subgroup analysis of the randomized phase III study 06011 of the EORTC Leukemia Cooperative Group and German MDS Study Group.
Lübbert M, Suciu S, Hagemeijer A, Rüter B, Platzbecker U, Giagounidis A, Selleslag D, Labar B,Germing U, Salih HR, Muus P, Pflüger KH, Schaefer HE, Bogatyreva L, Aul C, de Witte T, Ganser A, Becker H, Huls G, van der Helm L, Vellenga E, Baron F, Marie JP, Wijermans PW; EORTC Leukemia Group and the German MDS Study Group.
Ann Hematol. 2016 Jan;95(2):191-9.  Epub 2015 Nov 23.

Decitabine versus best supportive care in older patients with refractory anemia with excess blasts in transformation (RAEBt) - results of a subgroup analysis of the randomized phase III study 06011 of the EORTC Leukemia Cooperative Group and German MDS Study Group (GMDSSG).
Becker H, Suciu S, Rüter BH, Platzbecker U, Giagounidis A, Selleslag D, Labar B, Germing U, Salih HR, Muus P, Pflüger KH, Hagemeijer A, Schaefer HE, Fiaccadori V, Baron F, Ganser A, Aul C, de Witte T, Wijermans PW, Lübbert M.
Ann Hematol. 2015 Dec;94(12):2003-13. 

Results of a multicenter prospective phase II trial investigating the safety and efficacy of lenalidomide in patients with myelodysplastic syndromes with isolated del(5q) (LE-MON 5).
Schuler E, Giagounidis A, Haase D, Shirneshan K, Büsche G, Platzbecker U, Nolte F, Götze K, Schlenk RF, Ganser A, Letsch A, Braulke F, Lübbert M, Bug G, Schafhausen P, Bacher U, Gattermann N, Wulfert M, Haas R, Germing U.
Leukemia. 2015 Dec 15.

Early lenalidomide treatment for low and intermediate-1 International Prognostic Scoring System risk myelodysplastic syndromes with del(5q) before transfusion dependence.
Oliva EN, Lauseker M, Aloe Spiriti MA, Poloni A, Cortelezzi A, Palumbo GA, Balleari E, Sanpaolo G, Volpe A, Ricco A, Ronco F, Alati C, D'Errigo MG, Santacaterina I, Kündgen A, Germing U, Latagliata R.
Cancer Med. 2015 Dec;4(12):1789-97.

Frequency of del(12p) is commonly underestimated in myelodysplastic syndromes: Results from a German diagnostic study in comparison with an international control group.
Braulke F, Müller-Thomas C, Götze K, Platzbecker U, Germing U, Hofmann WK, Giagounidis AA, Lübbert M, Greenberg PL, Bennett JM, Solé F, Slovak ML, Ohyashiki K, Le Beau MM, Tüchler H, Pfeilstöcker M, Hildebrandt B, Aul C, Stauder R, Valent P, Fonatsch C, Bacher U, Trümper L, Haase D, Schanz J.
Genes Chromosomes Cancer. 2015 Dec;54(12):809-17.

Thiotepa-based high-dose therapy for autologous stem cell transplantation in lymphoma: a retrospective study from the EBMT.
Sellner L, Boumendil A, Finel H, Choquet S, de Rosa G, Falzetti F, Scime R, Kobbe G, Ferrara F, Delmer A, Sayer H, Amorim S, Bouabdallah R, Finke J, Salles G, Yakoub-Agha I, Faber E, Nicolas-Virelizier E, Facchini L, Vallisa D, Zuffa E, Sureda A, Dreger P.
Bone Marrow Transplant. 2016 Feb;51(2):212-8. Epub 2015 Nov 16.

Allogeneic stem cell transplantation after conditioning with treosulfan, etoposide and cyclophosphamide for patients with ALL: a phase II-study on behalf of the German Cooperative Transplant Study Group and ALL Study Group (GMALL).
Kröger N, Bornhäuser M, Stelljes M, Pichlmeier U, Trenschel R, Schmid C, Arnold R, Martin H, Heinzelmann M, Wolschke C, Meyer RG, Bethge W, Kobbe G, Ayuk F, Gökbuget N, Hölzer D, Zander A, Beelen D.
Bone Marrow Transplant. 2015 Dec;50(12):1503-7.

Ausgewählte Publikationen zu Lungenkrebs

ROS1 rearrangements in lung adenocarcinoma: prognostic impact, therapeutic options and genetic variability.
Scheffler M, Schultheis A, Teixido C, Michels S, Morales-Espinosa D, Viteri S, Hartmann W, Merkelbach-Bruse S, Fischer R, Schildhaus HU, Fassunke J, Sebastian M, Serke M, Kaminsky B, Randerath W, Gerigk U, Ko YD, Krüger S, Schnell R, Rothe A, Kropf-Sanchen C, Heukamp L, Rosell R, Büttner R, Wolf J.
Oncotarget. 2015 Apr 30;6(12):10577-85
Effects of Oxygen Supply During Training on Subjects With COPD Who Are Normoxemic at Rest and During Exercise: A Blinded Randomized Controlled Trial.
Spielmanns M, Fuchs-Bergsma C, Winkler A, Fox G, Krüger S, Baum K.
Respir Care. 2015 Apr;60(4):540-8
MET amplification status in therapy-naïve adeno- and squamous cell carcinomas of the lung.
Schildhaus HU, Schultheis AM, Rüschoff J, Binot E, Merkelbach-Bruse S, Fassunke J, Schulte W, Ko YD, Schlesinger A, Bos M, Gardizi M, Engel-Riedel W, Brockmann M, Serke M, Gerigk U, Hekmat K, Frank KF, Reiser M, Schulz H, Krüger S, Stoelben E, Zander T, Wolf J, Buettner R.
Clin Cancer Res. 2015 Feb

Ausgewählte Publikationen zu Urologischen Tumoren

Guidelines on Testicular Cancer: 2015 Update.
Albers P, Albrecht W, Algaba F, Bokemeyer C, Cohn-Cedermark G, Fizazi K, Horwich A, Laguna MP, Nicolai N, Oldenburg J.
Eur Urol. 2015 Dec;68(6):1054-68.

Single-agent Taxane Versus Taxane-containing Combination Chemotherapy as Salvage Therapy for Advanced Urothelial Carcinoma.
Sonpavde G, Pond GR, Choueiri TK, Mullane S, Niegisch G, Albers P, Necchi A, Lorenzo GD, Buonerba C, Rozzi A, Matsumoto K, Lee JL, Kitamura H, Kume H, Bellmunt J.
Eur Urol. 2015 Aug 8
[Follow-up of urological tumor treatment].
Ohlmann CH, Albers P, Boehm K, Graefen M, Hakenberg OW, Kuczyk M, Graf J, Peters I, Protzel C.
Urologe A. 2015 Aug 7
Prospective Randomized Trial Comparing Magnetic Resonance Imaging (MRI)-guided In-bore Biopsy to MRI-ultrasound Fusion and Transrectal Ultrasound-guided Prostate Biopsy in Patients with Prior Negative Biopsies.
Arsov C, Rabenalt R, Blondin D, Quentin M, Hiester A, Godehardt E, Gabbert HE, Becker N, Antoch G, Albers P, Schimmöller L.
Eur Urol. 2015 Jun 23
Prostate Cancer Unit Initiative in Europe: A position paper by the European School of Oncology.
Valdagni R, Van Poppel H, Aitchison M, Albers P, Berthold D, Bossi A, Brausi M, Denis L, Drudge-Coates L, De Santis M, Feick G, Harrison C, Haustermans K, Hollywood D, Hoyer M, Hummel H, Mason M, Mirone V, Müller SC, Parker C, Saghatchian M, Sternberg CN, Tombal B, van Muilekom E, Watson M, Wesselmann S, Wiegel T, Magnani T, Costa A.
Crit Rev Oncol Hematol. 2015 Aug;95(2):133-43

Significance of apoptotic and non-apoptotic disseminated tumor cells in the bone marrow of patients with clinically localized prostate cancer.
Todenhöfer T, Hennenlotter J, Faber F, Wallwiener D, Schilling D, Kühs U, Aufderklamm S, Bier S, Mischinger J, Gakis G, Fehm T, Stenzl A, Schwentner C.
Prostate. 2015 May;75(6):637-45.
Comparison of patient comfort between MR-guided in-bore and MRI/ultrasound fusion-guided prostate biopsies within a prospective randomized trial.
Arsov C, Rabenalt R, Quentin M, Hiester A, Blondin D, Albers P, Antoch G, Schimmöller L.
World J Urol. 2015 Jun 9
The use of targeted MR-guided prostate biopsy reduces the risk of Gleason upgrading on radical prostatectomy.
Arsov C, Becker N, Rabenalt R, Hiester A, Quentin M, Dietzel F, Antoch G, Gabbert HE, Albers P, Schimmöller L.
J Cancer Res Clin Oncol. 2015 May 27
[Metastasized prostate cancer : Position paper on the use of chemotherapy].
Ohlmann CH, Duensing S, Eichenauer R, König F, Machtens S, Schostak M, Thomas C, Albers P.
Urologe A. 2015 Jul;54(7):998-1001
The power of gene-based rare variant methods to detect disease-associated variation and test hypotheses about complex disease.
Moutsianas L, Agarwala V, Fuchsberger C, Flannick J, Rivas MA, Gaulton KJ, Albers PK; GoT2D Consortium, McVean G, Boehnke M, Altshuler D, McCarthy MI.
PLoS Genet. 2015 Apr 23;11(4):e1005165
The influence of ethylenediamine tetra acetic acid (EDTA) on the transformation and solubility of metallic palladium and palladium(II) oxide in the environment.
Zereini F, Wiseman CL, Vang M, Albers P, Schneider W, Schindl R, Leopold K.
Environ Sci Process Impacts. 2015 May;17(5):915-21
Second-Line Treatment of Advanced Urothelial Cancer with Paclitaxel and Everolimus in a German Phase II Trial (AUO Trial AB 35/09).
Niegisch G, Retz M, Thalgott M, Balabanov S, Honecker F, Ohlmann CH, Stöckle M, Bögemann M, Vom Dorp F, Gschwend J, Hartmann A, Ohmann C, Albers P.
Oncology. 2015;89(2):70-8. doi: 10.1159/000376551

The UBC-40 Urothelial Bladder Cancer cell line index: a genomic resource for functional studies.
Earl J, Rico D, Carrillo-de-Santa-Pau E, Rodríguez-Santiago B, Méndez-Pertuz M, Auer H, Gómez G, Grossman HB, Pisano DG, Schulz WA, Pérez-Jurado LA, Carrato A, Theodorescu D, Chanock S, Valencia A, Real FX.
BMC Genomics. 2015 May 22;16:403
The long noncoding RNA HOTAIR has tissue and cell type-dependent effects on HOX gene expression and phenotype of urothelial cancer cells.
Heubach J, Monsior J, Deenen R, Niegisch G, Szarvas T, Niedworok C, Schulz WA, Hoffmann MJ.
Mol Cancer. 2015 May 21;14:108
[Tumour-stroma interactions in urothelial cancer].
Hatina J, Kripnerová M, Tuková J, Šrámek J, Dvořák P, Pešta M, Dobrá J, Babuška V, Racek J, Sobol M, Philimonenko A, Hozák P, Czuba Z, Schulz WA, Strell C, Grimm S, Jennek S, Friedrich KH.
Urologe A. 2015 Apr;54(4):516-25
Inter-locus as well as intra-locus heterogeneity in LINE-1 promoter methylation in common human cancers suggests selective demethylation pressure at specific CpGs.
Nüsgen N, Goering W, Dauksa A, Biswas A, Jamil MA, Dimitriou I, Sharma A, Singer H, Fimmers R, Fröhlich H, Oldenburg J, Gulbinas A, Schulz WA, El-Maarri O.
Clin Epigenetics. 2015 Mar 1;7(1):17

[Epigenetics in urothelial cancer: Pathogenesis, improving diagnostics and developing novel treatment options].
Niegisch G, Hoffmann MJ, Koutsogiannouli EA, Schulz WA.
Urologe A. 2015 Apr;54(4):526-32
Establishment and characterization of a bladder cancer cell line with enhanced doxorubicin resistance by mevalonate pathway activation.
Greife A, Tukova J, Steinhoff C, Scott SD, Schulz WA, Hatina J.
Tumour Biol. 2015 May;36(5):3293-300

E-Learning in Urology: Implementation of the Learning and Teaching Platform CASUS® - Do Virtual Patients Lead to Improved Learning Outcomes? A Randomized Study among Students.
Schneider AT, Albers P, Müller-Mattheis V.
Urol Int. 2015;94(4):412-8

Quality assessment in prostate cancer centers certified by the German Cancer Society.
Kowalski C, Ferencz J, Albers P, Fichtner J, Wiegel T, Feick G, Wesselmann S.
World J Urol. 2015 Sep 21.

Cisplatin- Versus Non-Cisplatin-based First-Line Chemotherapy for Advanced Urothelial Carcinoma Previously Treated With Perioperative Cisplatin.
Locke JA, Pond GR, Sonpavde G, Necchi A, Giannatempo P, Paluri RK, Niegisch G, Albers P, Buonerba C, Di Lorenzo G, Vaishampayan UN, North SA, Agarwal N, Hussain SA, Pal S, Eigl BJ.
Clin Genitourin Cancer. 2015 Oct 24. pii: S1558-7673(15)00261-X.

Prostate cancer: No evidence for adjuvant chemotherapy in high-risk disease.
Albers P.
Nat Rev Urol. 2015 Nov;12(11):602-3. 

Phenotype plasticity rather than repopulation from CD90/CK14+ cancer stem cells leads to cisplatin resistance of urothelial carcinoma cell lines.
Skowron MA, Niegisch G, Fritz G, Arent T, van Roermund JG, Romano A, Albers P, Schulz WA, Hoffmann MJ.
J Exp Clin Cancer Res. 2015 Nov 25;34:144. 

Human endogenous retrovirus HERV-K(HML-2) activity in prostate cancer is dominated by a few loci.
Goering W, Schmitt K, Dostert M, Schaal H, Deenen R, Mayer J, Schulz WA.
Prostate. 2015 Dec;75(16):1958-71.

Efficacy and safety of gemcitabine, oxaliplatin, and paclitaxel in cisplatin-refractory germ cell cancer in routine care-Registry data from an outcomes research project of the German Testicular Cancer Study Group.
Seidel C, Oechsle K, Lorch A, Dieing A, Hentrich M, Hornig M, Grünwald V, Cathomas R, Meiler J, de Wit M, Bokemeyer C.
Urol Oncol. 2015 Dec 11. pii: S1078-1439(15)00559-1.

Brain Metastases in Patients With Germ Cell Tumors: Prognostic Factors and Treatment Options-An Analysis From the Global Germ Cell Cancer Group.
Feldman DR, Lorch A, Kramar A, Albany C, Einhorn LH, Giannatempo P, Necchi A, Flechon A, Boyle H, Chung P, Huddart RA, Bokemeyer C, Tryakin A, Sava T, Winquist EW, De Giorgi U, Aparicio J, Sweeney CJ, Cohn Cedermark G, Beyer J, Powles T.
J Clin Oncol. 2016 Feb 1;34(4):345-51. Epub 2015 Oct 12.

Ausgewählte Publikationen zu Tumoren bei Kindern

High incidence of Epstein-Barr virus (EBV)-positive Hodgkin lymphoma and Hodgkin lymphoma-like B-cell lymphoproliferations with EBV latency profile 2 in children with interleukin-2-inducible T-cell kinase deficiency.
Bienemann K, Borkhardt A, Klapper W, Oschlies I.
Histopathology. 2015 Feb 24
Monitoring minimal residual disease in children with high-risk relapses of acute lymphoblastic leukemia: prognostic relevance of early and late assessment.
Eckert C, Hagedorn N, Sramkova L, Mann G, Panzer-Grümayer R, Peters C, Bourquin JP, Klingebiel T, Borkhardt A, Cario G, Alten J, Escherich G, Astrahantseff K, Seeger K, Henze G, von Stackelberg A.
Leukemia. 2015 Aug;29(8):1648-55
The Duesseldorf warning signs for primary immunodeficiency: is it time to change the rules?
Lankisch P, Schiffner J, Ghosh S, Babor F, Borkhardt A, Laws HJ.
J Clin Immunol. 2015 Apr;35(3):273-9
The cell cycle regulator CCDC6 is a key target of RNA-binding protein EWS.
Duggimpudi S, Larsson E, Nabhani S, Borkhardt A, Hoell JI.
PLoS One. 2015 Mar 9;10(3):e0119066
Critical Situations in Children, Adolescents and Young Adults with Terminal Cancer within the Home Setting.
Kuhlen M, Balzer S, Friedland C, Borkhardt A, Janßen G.
Klin Padiatr. 2015 May;227(3):137-43
Autoimmune lymphoproliferative syndrome-like disease in patients with LRBA mutation.
Revel-Vilk S, Fischer U, Keller B, Nabhani S, Gámez-Díaz L, Rensing-Ehl A, Gombert M, Hönscheid A, Saleh H, Shaag A, Borkhardt A, Grimbacher B, Warnatz K, Elpeleg O, Stepensky P.
Clin Immunol. 2015 Jul;159(1):84-92
Cancer susceptibility syndromes in children in the area of broad clinical use of massive parallel sequencing.
Kuhlen M, Borkhardt A.
Eur J Pediatr. 2015 Aug;174(8):987-97
Denoising DNA deep sequencing data-high-throughput sequencing errors and their correction.
Laehnemann D, Borkhardt A, McHardy AC.
Brief Bioinform. 2015 May 29
DEREGULATION OF FAS LIGAND EXPRESSION AS A NOVEL CAUSE OF AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME LIKE DISEASE.
Nabhani S, Ginzel S, Miskin H, Revel-Vilk S, Harlev D, Fleckenstein B, Hönscheid A, Oommen PT, Kuhlen M, Thiele R, Laws HJ, Borkhardt A, Stepensky P, Fischer U.
Haematologica. 2015 Jun 25
Genomics and drug profiling of fatal TCF3-HLF-positive acute lymphoblastic leukemia identifies recurrent mutation patterns and therapeutic options.
Fischer U, Forster M, Rinaldi A, Risch T, Sungalee S, Warnatz HJ, Bornhauser B, Gombert M, Kratsch C, Stütz AM, Sultan M, Tchinda J, Worth CL, Amstislavskiy V, Badarinarayan N, Baruchel A, Bartram T, Basso G, Canpolat C, Cario G, Cavé H, Dakaj D, Delorenzi M, Dobay MP, Eckert C, Ellinghaus E, Eugster S, Frismantas V, Ginzel S, Haas OA, Heidenreich O, Hemmrich-Stanisak G, Hezaveh K, Höll JI, Hornhardt S, Husemann P, Kachroo P, Kratz CP, Kronnie GT, Marovca B, Niggli F, McHardy AC, Moorman AV, Panzer-Grümayer R, Petersen BS, Raeder B, Ralser M, Rosenstiel P, Schäfer D, Schrappe M, Schreiber S, Schütte M, Stade B, Thiele R, Weid NV, Vora A, Zaliova M, Zhang L, Zichner T, Zimmermann M, Lehrach H, Borkhardt A, Bourquin JP, Franke A, Korbel JO, Stanulla M, Yaspo ML.
Nat Genet. 2015 Jul 27
Next-generation-sequencing of recurrent childhood high hyperdiploid acute lymphoblastic leukemia reveals mutations typically associated with high risk patients.
Chen C, Bartenhagen C, Gombert M, Okpanyi V, Binder V, Röttgers S, Bradtke J, Teigler-Schlegel A, Harbott J, Ginzel S, Thiele R, Husemann P, Krell PF, Borkhardt A, Dugas M, Hu J, Fischer U.
Leuk Res. 2015 Jun 14. pii: S0145-2126(15)30332-5
Control of AC133/CD133 and impact on human hematopoietic progenitor cells through nucleolin.
Bhatia S, Reister S, Mahotka C, Meisel R, Borkhardt A, Grinstein E.
Leukemia. 2015 Jun 19

Visceral Leishmaniasis as a Possible Reason for Pancytopenia.
Koster KL, Laws HJ, Troeger A, Meisel R, Borkhardt A, Oommen PT.
Front Pediatr. 2015 Jun 29;3:59

MINCR is a MYC-induced lncRNA able to modulate MYC's transcriptional network in Burkitt lymphoma cells.
Doose G, Haake A, Bernhart SH, López C, Duggimpudi S, Wojciech F, Bergmann AK, Borkhardt A, Burkhardt B, Claviez A, Dimitrova L, Haas S, Hoell JI, Hummel M, Karsch D, Klapper W, Kleo K, Kretzmer H, Kreuz M, Küppers R, Lawerenz C, Lenze D, Loeffler M, Mantovani-Löffler L, Möller P, Ott G, Richter J, Rohde M, Rosenstiel P, Rosenwald A, Schilhabel M, Schneider M, Scholz I, Stilgenbauer S, Stunnenberg HG, Szczepanowski M, Trümper L, Weniger MA; ICGC MMML-Seq Consortium, Hoffmann S, Siebert R, Iaccarino I.
Proc Natl Acad Sci U S A. 2015 Sep 22;112(38):E5261-70.
Donor choice in haploidentical stem cell transplantation: fetal microchimerism is associated with better outcome in pediatric leukemia patients.
Kruchen A, Stahl T, Gieseke F, Binder TM, Özcan Z, Meisel R, Kreyenberg H, Bader P, Gruhn B, Greil J, Pfeiffer M, Döring M, Handgretinger R, Fehse B, Müller I.
Bone Marrow Transplant. 2015 Oct;50(10):1367-70.

Hodgkin lymphoma as a novel presentation of familial DICER1 syndrome
Kuhlen M, Hönscheid A, Schemme J, Merz H, Mauz-Körholz C, Borkhardt A, Troeger A.
Eur J Pediatr. 2015 Nov 3.

Selective downregulation of HLA-C and HLA-E in childhood acute lymphoblastic leukaemia.
Reusing SB, Manser AR, Enczmann J, Mulder A, Claas FH, Carrington M, Fischer JC, Borkhardt A, Babor F, Uhrberg M.
Br J Haematol. 2015 Nov 3.

GEMMs addressing Pax5 loss-of-function in childhood pB-ALL.
Auer F, Ingenhag D, Bhatia S, Enczmann J, Cobaleda C, Sanchez-Garcia I, Borkhardt A, Hauer J.
Eur J Med Genet. 2015 Nov 26. 

Symptoms and management of pediatric patients with incurable brain tumors in palliative home care.
Kuhlen M, Hoell J, Balzer S, Borkhardt A, Janssen G.
Eur J Paediatr Neurol. 2016 Mar;20(2):261-9. Epub 2015 Dec 22.

De novo PIK3R1 gain-of-function with recurrent sinopulmonary infections, long-lasting chronic CMV-lymphadenitis and microcephaly
Kuhlen M, Hönscheid A, Loizou L, Nabhani S, Fischer U, Stepensky P, Schaper J, Klapper W, Siepermann M, Schuster F, Meisel R, Borkhardt A.
Clin Immunol. 2016 Jan;162:27-30. Epub 2015 Oct 31.

Experiences in palliative home care of infants with life-limiting conditions.
Kuhlen M, Höll JI, Sabir H, Borkhardt A, Janßen G.
Eur J Pediatr. 2016 Mar;175(3):321-327. Epub 2015 Sep 28.

 

 

Ausgewählte Publikationen zu weiteren onkologischen Themen

Phomoxanthone A - From Mangrove Forests to Anticancer Therapy.
Frank M, Niemann H, Bohler P, Stork B, Wesselborg S, Lin W, Proksch P.
Curr Med Chem. 2015 Jul 16
Deubiquitinase inhibition by WP1130 leads to ULK1 aggregation and blockade of autophagy.
Drießen S, Berleth N, Friesen O, Löffler AS, Böhler P, Hieke N, Stuhldreier F, Peter C, Schink KO, Schultz SW, Stenmark H, Holland P, Simonsen A, Wesselborg S, Stork B.
Autophagy. 2015 Jul 24:0
Expression of a ULK1/2 binding-deficient ATG13 variant can partially restore autophagic activity in ATG13-deficient cells.
Hieke N, Löffler AS, Kaizuka T, Berleth N, Böhler P, Drießen S, Stuhldreier F, Friesen O, Assani K, Schmitz K, Peter C, Diedrich B, Dengjel J, Holland P, Simonsen A, Wesselborg S, Mizushima N, Stork B.
Autophagy. 2015 Jul
Platelets induce apoptosis via membrane-bound FasL.
Schleicher RI, Reichenbach F, Kraft P, Kumar A, Lescan M, Todt F, Göbel K, Hilgendorf I, Geisler T, Bauer A, Olbrich M, Schaller M, Wesselborg S, O'Reilly L, Meuth SG, Schulze-Osthoff K, Gawaz M, Li X, Kleinschnitz C, Edlich F, Langer HF.
Blood. 2015 Jul 31

Structural chromosome abnormalities, increased DNA strand breaks and DNA strand break repair deficiency in dermal fibroblasts from old female human donors.
Kalfalah F, Seggewiß S, Walter R, Tigges J, Moreno-Villanueva M, Bürkle A, Ohse S, Busch H, Boerries M, Hildebrandt B, Royer-Pokora B, Boege F.
Aging (Albany NY). 2015 Feb;7(2):110-22

Erythroid differentiation of human induced pluripotent stem cells is independent of donor cell type of origin.
Dorn I, Klich K, Arauzo-Bravo MJ, Radstaak M, Santourlidis S, Ghanjati F, Radke TF, Psathaki OE, Hargus G, Kramer J, Einhaus M, Kim JB, Kögler G, Wernet P, Schöler HR, Schlenke P, Zaehres H.
Haematologica. 2015 Jan;100(1):32-41
DNA damage response in neonatal and adult stromal cells compared with induced pluripotent stem cells.
Liedtke S, Biebernick S, Radke TF, Stapelkamp D, Coenen C, Zaehres H, Fritz G, Kogler G.
Stem Cells Transl Med. 2015 Jun;4(6):576-89
Age-Related Increase of EED Expression in Early Hematopoietic Progenitor Cells is Associated with Global Increase of the Histone Modification H3K27me3.
Graffmann N, Brands J, Görgens A, Vitoriano da Conceição Castro S, Santourlidis S, Reckert A, Michele I, Ritz-Timme S, Fischer JC, Adjaye J, Kögler G, Giebel B, Uhrberg M.
Stem Cells Dev. 2015 Sep 1;24(17):2018-31
Characterization of regenerative phenotype of unrestricted somatic stem cells from human umbilical cord blood by functional secretome analysis.
Schira J, Falkenberg H, Hendricks M, Waldera-Lupa DM, Kogler G, Meyer HE, Muller HW, Stuhler K.
Mol Cell Proteomics. 2015 Jul 16

High on-treatment platelet reactivity in transcatheter aortic valve implantation patients.
Polzin A, Schleicher M, Seidel H, Scharf RE, Merx MW, Kelm M, Zeus T.
Eur J Pharmacol. 2015 Mar 15;751:24-7
Elevated risk of thrombophilia in agenesis of the vena cava as a factor for deep vein thrombosis.
Sagban TA, Scharf RE, Wagenhäuser MU, Oberhuber A, Schelzig H, Grabitz K, Duran M.
Orphanet J Rare Dis. 2015 Jan 21;10:3

Discovery of Novel, Potent, and Specific Cell-Death Inducers in the Jurkat Acute Lymphoblastic Leukemia Cell Line.
Carosati E, van den Höfel N, Reif M, Randazzo GM, Stanitzki B, Stevens J, Gabbert HE, Cruciani G, Mannhold R, Mahotka C.
ChemMedChem. 2015 Aug 12

TSG (2,3,5,4'-Tetrahydroxystilbene-2-O- β -D-glucoside) from the Chinese Herb Polygonum multiflorum Increases Life Span and Stress Resistance of Caenorhabditis elegans.
Büchter C, Zhao L, Havermann S, Honnen S, Fritz G, Proksch P, Wätjen W.
Oxid Med Cell Longev. 2015;2015:124357.

Circulating NOS3 modulates left ventricular remodeling following reperfused myocardial infarction.
Gorressen S, Stern M, van de Sandt AM, Cortese-Krott MM, Ohlig J, Rassaf T, Gödecke A, Fischer JW, Heusch G, Merx MW, Kelm M.
PLoS One. 2015 Apr 14;10(4):e0120961

Impact of eNOS-Dependent Oxidative Stress on Endothelial Function and Neointima Formation.
Suvorava T, Nagy N, Pick S, Lieven O, Rüther U, Dao VT, Fischer JW, Weber M, Kojda G.
Antioxid Redox Signal. 2015 Jun 8

CT-based delineation of organs at risk in the head and neck region: DAHANCA, EORTC, GORTEC, HKNPCSG, NCIC CTG, NCRI, NRG Oncology and TROG consensus guidelines.
Brouwer CL, Steenbakkers RJ, Bourhis J, Budach W, Grau C, Grégoire V, van Herk M, Lee A, Maingon P, Nutting C, O'Sullivan B, Porceddu SV, Rosenthal DI, Sijtsema NM, Langendijk JA.
Radiother Oncol. 2015 Aug 13
Internal Mammary and Medial Supraclavicular Irradiation in Breast Cancer.
Poortmans PM, Collette S, Kirkove C, Van Limbergen E, Budach V, Struikmans H, Collette L, Fourquet A, Maingon P, Valli M, De Winter K, Marnitz S, Barillot I, Scandolaro L, Vonk E, Rodenhuis C, Marsiglia H, Weidner N, van Tienhoven G, Glanzmann C, Kuten A, Arriagada R, Bartelink H, Van den Bogaert W; EORTC Radiation Oncology and Breast Cancer Groups.
N Engl J Med. 2015
Erratum to: DEGRO practical guidelines for radiotherapy of breast cancer V : Therapy for locally advanced and inflammatory breast cancer, as well as local therapy in cases with synchronous distant metastases.
Budach W, Matuschek C, Bölke E, Dunst J, Feyer P, Fietkau R, Haase W, Harms W, Piroth MD, Sautter-Bihl ML, Sedlmayer F, Souchon R, Wenz F, Sauer R; Breast Cancer Expert Panel of the German Society of Radiation Oncology (DEGRO).
Strahlenther Onkol. 2015 Aug;191(8):634

Glycosaminoglycan chemical exchange saturation transfer at 3T MRI in asymptomatic knee joints.
Schleich C, Bittersohl B, Miese F, Schmitt B, Müller-Lutz A, Sondern M, Antoch G, Krauspe R, Zilkens C.
Acta Radiol. 2015 Aug 7.
Locoregional tumour evaluation of squamous cell carcinoma in the head and neck area: a comparison between MRI, PET/CT and integrated PET/MRI.
Schaarschmidt BM, Heusch P, Buchbender C, Ruhlmann M, Bergmann C, Ruhlmann V, Schlamann M, Antoch G, Forsting M, Wetter A.
Eur J Nucl Med Mol Imaging. 2015 Aug 6
Hybrid 18F-labeled Fluoride Positron Emission Tomography/Magnetic Resonance (MR) Imaging of the Sacroiliac Joints and the Spine in Patients with Axial Spondyloarthritis: A Pilot Study Exploring the Link of MR Bone Pathologies and Increased Osteoblastic Activity.
Buchbender C, Ostendorf B, Ruhlmann V, Heusch P, Miese F, Beiderwellen K, Schneider M, Braun J, Antoch G, Baraliakos X.
J Rheumatol. 2015 Jul 1

Clinical and molecular characterization of patients with heterozygous mutations in wilms tumor suppressor gene 1.
Lehnhardt A, Karnatz C, Ahlenstiel-Grunow T, Benz K, Benz MR, Budde K, Büscher AK, Fehr T, Feldkötter M, Graf N, Höcker B, Jungraithmayr T, Klaus G, Koehler B, Konrad M, Kranz B, Montoya CR, Müller D, Neuhaus TJ, Oh J, Pape L, Pohl M, Royer-Pokora B, Querfeld U, Schneppenheim R, Staude H, Spartà G, Timmermann K, Wilkening F, Wygoda S, Bergmann C, Kemper MJ.
Clin J Am Soc Nephrol. 2015 May 7;10(5):825-31. 

Discovery of Novel, Potent, and Specific Cell-Death Inducers in the Jurkat Acute Lymphoblastic Leukemia Cell Line.
Carosati E, van den Höfel N, Reif M, Randazzo GM, Stanitzki B, Stevens J, Gabbert HE, Cruciani G, Mannhold R, Mahotka C.
ChemMedChem. 2015 Oct;10(10):1700-6. 

Juvenile myelomonocytic leukemia displays mutations in components of the RAS pathway and the PRC2 network.
Caye A, Strullu M, Guidez F, Cassinat B, Gazal S, Fenneteau O, Lainey E, Nouri K, Nakhaei-Rad S, Dvorsky R, Lachenaud J, Pereira S, Vivent J, Verger E, Vidaud D, Galambrun C, Picard C, Petit A, Contet A, Poirée M, Sirvent N, Méchinaud F, Adjaoud D, Paillard C, Nelken B, Reguerre Y, Bertrand Y, Häussinger D, Dalle JH, Ahmadian MR, Baruchel A, Chomienne C, Cavé H.
Nat Genet. 2015 Nov;47(11):1334-40. 

 

Identification of cytokine-induced modulation of microRNA expression and secretion as measured by a novel microRNA specific qPCR assay.
Benes V, Collier P, Kordes C, Stolte J, Rausch T, Muckentaler MU, Häussinger D, Castoldi M.
Sci Rep. 2015 Jun 25;5:11590.

CRISPR/Cas9 somatic multiplex-mutagenesis for high-throughput functional cancer genomics in mice.
Weber J, Öllinger R, Friedrich M, Ehmer U, Barenboim M, Steiger K, Heid I, Mueller S, Maresch R, Engleitner T, Gross N, Geumann U, Fu B, Segler A, Yuan D, Lange S, Strong A, de la Rosa J,Esposito I, Liu P, Cadiñanos J, Vassiliou GS, Schmid RM, Schneider G, Unger K, Yang F, Braren R, Heikenwälder M, Varela I, Saur D, Bradley A, Rad R.
Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):13982-7.

Patient-Controlled Therapy of Breathlessness in Palliative Care: A New Therapeutic Concept for Opioid Administration? 
Schmitz A, Schulz C, Friebel U, Hohlfeld T, Bausewein C. 
J Pain Symptom Manage. 2015 Nov 11. 

Esophageal squamous cell carcinoma cells modulate chemokine expression and hyaluronan synthesis in fibroblasts.
Kretschmer I, Freudenberger T, Twarock S, Yamaguchi Y, Grandoch M, Fischer JW. 
J Biol Chem. 2015 Dec 23. 

The characteristics of patients who discontinue their dying process - an observational study at a single university hospital centre.
Schulz C, Schlieper D, Altreuther C, Schallenburger M, Fetz K, Schmitz A. 
BMC Palliat Care. 2015 Dec 7;14(1):72. 

Pancreas-specific activation of mTOR and loss of p53 induce tumors reminiscent of acinar cell carcinoma. 
Kong B, Cheng T, Qian C, Wu W, Steiger K, Cao J, Schlitter AM, Regel I, Raulefs S, Friess H, Erkan M, Esposito I, Kleeff J, Michalski CW. 
Mol Cancer. 2015 Dec 18;14(1):212.

Assessing quality and functionality of DNA isolated from FFPE tissues through external quality assessment in tissue banks. 
Ahmad-Nejad P, Duda A, Sucker A, Werner M, Bronsert P, Stickeler E, Reifenberger G, Malzkorn B, Oberländer M, Habermann JK, Bruch HP, Linnebacher M, Schadendorf D, Neumaier M.  
Clin Chem Lab Med. 2015 Nov;53(12):1927-34. 

Evaluation of the Outcome of Lung Nodules Missed on 18F-FDG PET/MRI Compared with 18F-FDG PET/CT in Patients with Known Malignancies. 
Sawicki LM, Grueneisen J, Buchbender C, Schaarschmidt BM, Gomez B, Ruhlmann V, Umutlu L, Antoch G, Heusch P. 
J Nucl Med. 2016 Jan;57(1):15-20. Epub 2015 Oct 29.

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