Curriculum Vitae - Max Anstötz
Berufliche Laufbahn:
seit 2022: Universitätsprofessor für zelluläre Neuroanatomie
HHU Düsseldorf - Institut für Anatomie II
Physio-pathologische Mechanismen kortikaler Hirnentwickung
2019 - 2022: Research Assistent Professor
Northwestern University Chicago - Department of Neuroscience
Physio-pathologischer Einfluss von Cajal-Retzius-Zellen im Hippocampus & Pathologische Mechanismen im Subiculum bei Temporallappen-Epilepsie
2018 - 2019: Wissenschaftlicher Mitarbeiter
Northwestern University Chicago - Department of Neuroscience (PI Prof. Maccaferri)
Physio-pathologischer Einfluss von Cajal-Retzius-Zellen im Hippocampus & Pathologische Mechanismen im Subiculum bei Temporallappen-Epilepsie
2015 - 2018: Wissenschaftlicher Mitarbeiter
UKE Hamburg - Institut für Neuroanatomie (AG Prof. Rune)
Entwicklung kortikaler Architektur im Hippocampus unterphysiologischen und pathologischen Einflüssen
2011 - 2015: Promotion
FZ Jülich - INM-2 (AG Prof. Lübke)
Entwicklung, Morphologie und synaptische Konnektivität neokortikaler und hippocampaler Cajal-Retzius Zellen
Ausbildung:
2016 Promotion zum Dr. med. (summa cum laude) - FZ Jülich / RWTH-Aachen
2015 Approbation als Arzt
2014 Staatsexamen Humanmedizin - RWTH Aachen
Auszeichnungen:
2023 Lehrpreis der Medizinischen Fakultät HHU Düsseldorf
2018 Teacher-of-the-year Award des UKE Hamburg (2. und 3. Platz)
2017 Teacher-of-the-year Award des UKE Hamburg (1. Platz)
2017 Borchers-Plakette der RWTH Aachen
2016 Young-Investigator-Award der Anatomischen Gesellschaft (Jahrestagung 2016 - Göttingen)
2008 Stipendium der Studienstiftung des deutschen Volkes
Publikationen:
stand October 20232023
Schröder JK, Abdel-Hafiz L., Ali AAH, Cousin TC, Hallenberger J, Rodrigues Almeida F, Anstötz M, Lenz M, Vlachos A, von Gall C, Tundo-Lavalle F
Effects of the Light/Dark Phase and Constant Light on Spatial Working Memory and Spine Plasticity in the Mouse Hippocampus
Cells (doi: 10.3390/cells12131758)
Gallus M, Roll W, Dik A, Barca C, Zinnhardt B, Hicking G, Mueller C, Naik VN, Anstötz M, Krämer J, Rolfes L, Wachsmuth L, Pitsch J, van Loo KMJ, Räuber S, Okada H, Wimberley C, Strippel C, Golombeck KS, Johnen A, Kovac S, Groß CC, Backhaus P, Seifert R, Lewerenz J, Surges R, Elger CE, Wiendl H, Ruck T, Becker AJ, Faber C, Jacobs AH, Bauer J, Meuth SG, Schäfers M, Melzer N
Translational imaging of TSPO reveals pronounced innate inflammation in human and murine CD8 T cell-mediated limbic encephalitis.
Science Advance (doi: 10.1126/sciadv.abq7595)
2022
Anstötz M, Lee SK, Maccaferri G
Glutamate released by Cajal-Retzius cells impacts specific hippocampal circuits and behaviors.
Cell Reports (DOI: 10.1016/j.celrep.2022.110822)
Comment by Sanchez-Bellot and de La Prida:
More Than Reels: Cajal-Retzius Cells Become Active
Epilepsy Currents (DOI: 10.1177/15357597221123453)
Anstötz M*, Rollenhagen A*, Klook K, Kasugai Y, Sätzler K, Molnar E, Ferraguti F, Lübke J
Layer-specific distribution and expression pattern of AMPA- and NMDA-type glutamate receptors in the barrel field of the adult rat somatosensory cortex: a quantitative electron microscopic analysis
Cerebral Cortex (DOI: 10.1093/cercor/bhac212) *equally contributed
2021
Anstötz M*, Fiske MP*, Maccaferri G
Impaired KCC2 function triggers interictal-like activity driven by parvalbumin-expressing interneurons in the isolated subiculum in vitro
Cerebral Cortex (DOI: 10.1093/cercor/bhab115) *equally contributed
Comment by Ahmed OJ:
Mechanisms of Subiculum Hyperexcitability in Temporal Lobe Epilepsy.
Epilepsy Currents (DOI: 10.1177/15357597211048601)
2020
Meyer MAA, Anstötz M, Ren LY, Fiske MP, Guedea AL, Grayson V, Schroth SL, Cicvaric A, Nishimori K, Maccaferri G, Radulovic J
Stress-related memories disrupt sociability and associated patterning of hippocampal activity: a role of hilar oxytocin receptor-positive interneurons
Transl Psychiatry (DOI: 10.1038/s41398-020-01091-y)
Haumann I, Sturm MA, Anstötz M, Rune GM
GPER1 signaling initiates migration of female V-SVZ derived cells
iScience (DOI: 10.1016/j.isci.2020.101077)
Fiske MP, Anstötz M, Welty LJ, Maccaferri G
The intrinsic cell type-specific excitatory connectivity of the developing mouse subiculum is sufficient to generate synchronous epileptiform activity.
J Physiol (DOI: 10.1113/JP279561)
2019
Anstötz M, Maccaferri G
A toolbox of criteria for distinguishing Cajal-Retzius cells from other neuronal types in the postnatal mouse hippocampus
eNeuro (DOI: 10.1523/ENEURO.0516-19.2019)
Ali A*, Schwarz-Herzke B*, Rollenhagen A, Anstötz M, Holub M, Lübke J, Rosee C, Schnittler HJ, von Gall C
Bmal1-deficiency affects glial synaptic coverage of the hippocampal mossy fiber synapse and the actin cytoskeleton in astrocytes
Glia (DOI: 10.1002/glia.23754) *equally contributed
Brandt N, Vierk R, Fester L, Anstötz M, Zhou L, Heilmann LF, Kind S, Steffen P, Rune GM
Sex-specific differentiation of hippocampal neurons
Cerebral Cortex (DOI: 10.1093/cercor/bhz265)
2018
Meseke M, Neumüller F, Brunne B, Li X, Anstötz M, Pohlkamp T, Rogalla M, Herz J, Rune G, Bender R
Distal Dendritic Enrichment of HCN1 Channels in Hippocampal CA1 Is Promoted by Estrogen, but Does Not Require Reelin
eNeuro (DOI: 10.1523/ENEURO.0258-18.2018)
Anstötz M, Karsak M, Rune GM
Integrity of Cajal-Retzius cells in the reeler-mouse hippocampus.
Hippocampus (DOI: 10.1002/hipo.23049)
Anstötz M, Lee SK, Maccaferri G.
Expression of TRPV1 channels by Cajal-Retzius cells and layer-specific modulation of synaptic transmission by capsaicin in the mouse hippocampus.
Journal of Physiology (DOI: 10.1113/JP275685)
Comment by Thompson RJ:
A direct demonstration of functional TRPV1 in Cajal–Retzius cells,
The Journal of Physiology (DOI: 10.1113/JP276521)
Anstötz M*, Quattrocolo G*, Maccaferri G.
Cajal-Retzius cells and GABAergic interneurons of the developing hippocampus: Close electrophysiological encounters of the third kind.
Brain Research (DOI: 10.1016/j.brainres.2018.07.028) *equally contributed
2017
Anstötz M, Lee SK, Neblett TI, Rune GM, Maccaferri G
Experience-Dependent Regulation of Cajal-Retzius Cell Networks in the Developing and Adult Mouse Hippocampus
Cerebral Cortex (DOI: doi.org/10.1093/cercor/bhx153)
Haumann I*, Junghans D*, Anstötz M*, Frotscher M
Presynaptic localization of GluK5 in rod photoreceptors suggests a novel function of high affinity glutamate receptors in the mammalian retina
PLoS One (DOI: 10.1371/journal.pone.0172967) *equally contributed
2016
Anstötz M, Huang H, Haumann I, Marchionni I, Maccaferri G, Lübke JHR
Structural heterogeneity and synaptic connectivity of Cajal-Retzius cells in the mouse postnatal hippocampus
Cerebral Cortex (DOI: 10.1093/cercor/bhv271)
2015
Anstötz M, Cosgrove KE, Hack I, Mugnaini E, Maccaferri G, Lübke JHR
Morphology, input–output relations and synaptic connectivity of Cajal-Retzius cells in layer 1 of the developing neocortex of CXCR4-EGFP mice
Brain Structure & Function (DOI: 10.1007/s00429-013-0627-2)
2014
Rollenhagen A, Klook K, Sätzler K, Qi G, Anstötz M, Feldmeyer D, Lübke JHR
Structural determinants underlying the high efficacy of synaptic boutons in layer4 of the adult rat ‘barrel’ cortex
Brain Structure & Function (DOI: 10.1007/s00429-014-0850-5)