Specific objectives

To investigate

• the particle composition of indoor sources (candle burning, toasting bread & frying sausages)
• personal 2-hour exposure
• whether exposure to particles from indoor activities leads to health-related changes in healthy volunteer
• the role of different particle metrics (particle mass concentration - PMC, particle surface concentration - PSC and particle number concentration - PNC), paying special attention to the UFPs by analysing the effects of different particle size fractions of UFPs

Study design

Controlled cross-over exposure study

Study population:

55 healthy volunteers (32.5±16.3 years)

Study area

City of Duisburg, Düsseldorf, Mülheim, Essen

Study period

2012-2013

Current status

completed

Principal investigators

Exposure assessment and characterization

• Prof. Dr. Thomas Kuhlbusch, BauA - Federal Office for Occupational Safety and Occupational Medicine, Dortmund, Germany & CENIDE - Center for Nanointegration, Duisburg, Germany
• Dr. Bryan Hellack , IUTA – Institute of Energy and Environmental Technology, Duisburg, Germany & UBA - Federal Environmental Agency of Germany, Langen, Germany
• Dr. Ulrich Quass, LANUV - Landesamt für Natur, Umwelt und Verbraucherschutz Nordrhein-Westfalen Fachbereich 44, Essen, Germany

Toxicological analyzes

• Dr. Roel Schins, IUF – Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany

Overall coordination, health examinations, data management and statistical analysis

• Prof. Barbara Hoffmann, MPH, Institute of Occupational, Social and Environmental Medicine, Heinrich-Heine-University Düsseldorf, Germany
• Dr. Vanessa Soppa, Institute of Occupational, Social and Environmental Medicine, Heinrich-Heine-University Düsseldorf, Germany
• Anna Buschka, Institute of Occupational, Social and Environmental Medicine, Heinrich-Heine-University Düsseldorf, Germany
• Dr. Samir Shinnawi, Diagnostic Radiology Resident at Rambam Health Care Campus, Tel Aviv, Israel
• Brigitta Sasse, Institute of Occupational, Social and Environmental Medicine, Heinrich-Heine-University Düsseldorf, Germany
• Boris Ludwig, Institute of Occupational, Social and Environmental Medicine, Heinrich-Heine-University Düsseldorf, Germany

Cooperation Partners

• IUTA – Institute of Energy and Environmental Technology, Duisburg, Germany

External Funding

• Federal Environment Agency (Unmweltbundsamt UBA) (2012)

Project Publications

• Soppa VJ, Shinnawi S, Henning F, Sasse B, Hellack B, Kaminski H, Quass U, Schins RPF, Kuhlbusch TAJ, Hoffmann B. Effects of short-term exposure to fine and ultrafine particles from indoor sources on arterial stiffness – A randomized sham-controlled exposure study. International Journal of Hygiene and Environmental Health 2019; 222(8):1115-1132. doi: 10.1016/j.ijheh.2019.08.002.

• Soppa VJ, Schins RPF, Hennig F, et al. Arterial blood pressure responses to short-term exposure to fine and ultrafine particles from indoor sources – A randomized sham-controlled exposure study of healthy volunteers. Environ. Res. [electronic article] 2017; 158:225-232.

• Soppa VJ, Schins RPF, Hennig F, et al. Respiratory Effects of Fine and Ultrafine Particles from Indoor Sources – A Randomized Sham-Controlled Exposure Study of Healthy Volunteers. Int. J. Environ. Res. Public Health [electronic article] 2014; 11(7):6871-6889.

Related Publications

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