Prof. Dr. Gödecke

Originalarbeiten

Weser,S., Gerlach,M., Kwak,D.M., Czerwinska,M., and Gödecke,A. (2006). Detection of TAP-tagged proteins in Western blot, confocal laser scanning microscopy and FACS using the ZZ-domain. J. Biochem. Biophys. Methods 68, 189-194.

Pfeiffer,T., Wallich,M., Sandmann,W., Schrader,J., and Gödecke,A. (2006). Lipoplex gene transfer of inducible nitric oxide synthase inhibits the reactive intimal hyperplasia after expanded polytetrafluoroethylene bypass grafting. J. Vasc. Surg. 43, 1021-1027.

Gödecke,A. (2006). AAV vector re-targeting: A small step on the way to cardiac-specific gene transfer. Cardiovasc. Res. 70, 6-8.

Özüyaman,B., Ding,Z., Buchheiser,A., Koszalka,P., Braun,N., Gödecke,A., Decking,U.K., Zimmermann,H., and Schrader,J. (2006). Adenosine produced via the CD73/ecto-5''-nucleotidase pathway has no impact on erythropoietin production but is associated with reduced kidney weight. Pflugers Arch. 452, 324-331.

Kleinbongard,P., Schulz,R., Rassaf,T., Lauer,T., Dejam,A., Jax,T., Kumara,I., Gharini,P., Kabanova,S., Özüyaman,B., Schnurch,H.G., Gödecke,A., Weber,A.A., Robenek,M., Robenek,H., Bloch,W., Rosen,P., and Kelm,M. (2006). Red blood cells express a functional endothelial nitric oxide synthase. Blood 107, 2943-2951.

Gödecke,A. (2006). On the impact of NO-globin interactions in the cardiovascular system. Cardiovasc. Res. 69, 309-317.

Özüyaman,B., Ebner,P., Niesler,U., Ziemann,J., Kleinbongard,P., Jax,T., Gödecke,A., Kelm,M., and Kalka,C. (2005). Nitric oxide differentially regulates proliferation and mobilization of endothelial progenitor cells but not of hematopoietic stem cells. Thromb. Haemost. 94, 770-772.

Özüyaman,B., Gödecke,A., Küsters,S., Kirchhoff,E., Scharf,R.E., and Schrader,J. (2005). Endothelial nitric oxide synthase plays a minor role in inhibition of arterial thrombus formation. Thromb. Haemost. 93, 1161-1167.

Flögel,U., Laussmann,T., Gödecke,A., Abanador,N., Schafers,M., Fingas,C.D., Metzger,S., Levkau,B., Jacoby,C., and Schrader,J. (2005). Lack of myoglobin causes a switch in cardiac substrate selection. Circ. Res. 96, e68-e75.

Merx,M.W., Gödecke,A., Flögel,U., and Schrader,J. (2005). Oxygen supply and nitric oxide scavenging by myoglobin contribute to exercise endurance and cardiac function. FASEB J. 19, 1015-1017.

Bubikat,A., De Windt,L.J., Zetsche,B., Fabritz,L., Sickler,H., Eckardt,D., Gödecke,A., Baba,H.A., and Kuhn,M. (2005). Local atrial natriuretic peptide signaling prevents hypertensive cardiac hypertrophy in endothelial nitric-oxide synthase-deficient mice. J. Biol. Chem. 280, 21594-21599.

Koszalka,P., Özüyaman,B., Huo,Y., Zernecke,A., Flögel,U., Braun,N., Buchheiser,A., Decking,U.K., Smith,M.L., Sevigny,J., Gear,A., Weber,A.A., Molojavyi,A., Ding,Z., Weber,C., Ley,K., Zimmermann,H., Gödecke,A., and Schrader,J. (2004). Targeted disruption of cd73/ecto-5''-nucleotidase alters thromboregulation and augments vascular inflammatory response. Circ. Res. 95, 814-821.

 Flögel U, Gödecke A, Klotz LO, Schrader J. (2004)

Role of myoglobin in the antioxidant defense of the heart.

FASEB J. 2004 Jul; 18(10): 1156-1158. 

Sasse A, Ding Z, Wallich M, Gödecke A, Schrader J. (2004)

Vascular transfer of adenovirus is augmented by nitric oxide in the rat heart.

Am J Physiol Heart Circ Physiol. 2004 Sep; 287(3): H1362-1368. 

Gödecke A, Schrader J. (2004)

The Janus faces of NO?

Circ Res. 2004 Apr 2; 94(6): e55. 

Wallerath T, Gödecke A, Molojavyi A, Li H, Schrader J, Forstermann U. (2004)

Dexamethasone lacks effect on blood pressure in mice with a disrupted endothelial NO synthase gene.

Nitric Oxide. 2004 Feb; 10(1): 36-41. 

Liimatta EV, Gödecke A, Schrader J, Hassinen IE. (2004)

Regulation of cellular respiration in myoglobin-deficient mouse heart.

Mol Cell Biochem. 2004 Jan-Feb; 256-257(1-2): 201-208. 

Nofer JR, van der Giet M, Tolle M, Wolinska I, von Wnuck Lipinski K, Baba HA, Tietge UJ, Gödecke A, Ishii I, Kleuser B, Schafers M, Fobker M, Zidek W, Assmann G, Chun J, Levkau B. (2004)

HDL induces NO-dependent vasorelaxation via the lysophospholipid receptor S1P3.

J Clin Invest. 2004 Feb; 113(4): 569-581. 

Ding Z, Fach C, Sasse A, Gödecke A, Schrader J. (2004)

A minimally invasive approach for efficient gene delivery to rodent hearts.

Gene Ther. 2004 Feb; 11(3): 260-265. 

Gödecke A. (2003)

PAF, PIP(3) and NO: emerging role in reperfusion injury.

Cardiovasc Res. 2003 Nov 1; 60(2): 215-216. 

Kleinbongard P, Dejam A, Lauer T, Rassaf T, Schindler A, Picker O, Scheeren T, Gödecke A, Schrader J,

Schulz R, Heusch G, Schaub GA, Bryan NS, Feelisch M, Kelm M. (2003)

Plasma nitrite reflects constitutive nitric oxide synthase activity in mammals.

Free Radic Biol Med. 2003 Oct 1; 35 (7): 790-796. 

Wunderlich C., Flögel U., Gödecke A., Heger J., Schrader J. (2003).

Acute Inhibition of Myoglobin Impairs Contractility and Energy State of iNOS-Overexpressing Hearts.

Circ. Res. 2003 Jun 27; 92 (12): 1352-1358 

Gödecke A., Molojavyi A., Heger J., Flögel U., Ding Z., Jacoby C., Schrader J. (2003).

Myoglobin Protects the Heart from Inducible Nitric-oxide Synthase (iNOS)-mediated Nitrosative Stress.

J. Biol. Chem. 2003 Jun 13; 278 (24), 21761-21766. 

Doreulee N., Sergeeva O.A., Yanovsky Y., Chepkova A.N., Selbach O., Gödecke A., Schrader J.,

Haas H.L. (2003).

Cortico-striatal synaptic plasticity in endothelial nitric oxide synthase deficient mice.

Brain Res. 2003 Feb 21; 964 (1): 159-163. 

Henrich M., Hoffmann K., Konig P., Gruss M., Fischbach T., Gödecke A., Hempelmann G., Kummer W. (2002). Sensory Neurons Respond to Hypoxia with NO Production Associated with Mitochondria.

Mol. Cell Neurosci. 20, 307-322. 

Wegener J.W., Gödecke A., Schrader J., Nawrath H. (2002).

Effects of nitric oxide donors on cardiac contractility in wild-type and myoglobin-deficient mice.

Br. J. Pharmacol. 136, 415-420. 

Ding Z., Gödecke A., Schrader J. (2002).

Contribution of cytochrome P450 metabolites to bradykinin-induced vasodilation in endothelial NO synthase deficient mouse hearts.

Br. J. Pharmacol. 135, 631-638. 

Heger J., Gödecke A., Flögel U., Merx M.W., Molojavyi A., Kuhn-Velten W.N., Schrader J. (2002).

Cardiac-specific overexpression of inducible nitric oxide synthase does not result in severe cardiac dysfunction.

Circ. Res. 90, 93-99. 

Gödecke A., Ziegler M., Ding Z., and Schrader J. (2002).

Endothelial dysfunction of coronary resistance vessels in apoE-/- mice involves NO but not prostacyclin-dependent mechanisms.

Cardiovasc. Res. 53, 253-262. 

Dere E., Frisch C., Souza Silva M.A., Gödecke A., Schrader J., Huston J.P. (2001).

Unaltered radial maze performance and brain acetylcholine of the endothelial nitric oxide synthase knockout mouse.

Neuroscience 107, 561-570. 

Ishibashi T.,Gödecke A., Schrader J. (2001)

Protein kinase A- and C-dependent modulation of murine inducible nitric oxide synthase.

Tohoku J. Exp. Med. 194, 75-90. 

Doreulee N., Brown R.E., Yanovsky Y.,Gödecke A., Schrader J., Haas H.L. (2001)

Defective hippocampal mossy fiber long-term potentiation in endothelial nitric oxide synthase knockout mice.

Synapse 41, 191-194. 

Gödecke A., Heinicke T., Kamkin A., Kiseleva I., Strasser R.H., Decking U.K., Stumpe T., Isenberg G.,

Schrader J. (2001)

Inotropic response to beta-adrenergic receptor stimulation and anti- adrenergic effect of ACh in endothelial NO synthase-deficient mouse hearts.

J. Physiol 532, 195-204. 

Merx M.W., Flögel U., Stumpe T., Gödecke A., Decking U.K.,Schrader J. (2001)

Myoglobin facilitates oxygen diffusion.

FASEB J. 15, 1077-1079. 

Armour K.E., Armour K.J., Gallagher M.E., Gödecke A., Helfrich M.H., Reid D.M., Ralston S.H. (2001)

Defective bone formation and anabolic response to exogenous estrogen in mice with targeted disruption of endothelial nitric oxide synthase.

Endocrinology 142, 760-766. 

Flögel U., Merx M.W., Gödecke A., Decking U.K., Schrader J. (2001)

Myoglobin: A scavenger of bioactive NO.

Proc. Natl. Acad. Sci. U. S. A 98, 735-740. 

Frisch C., Dere E., Silva M.A., Gödecke A., Schrader J., Huston J.P. (2000)

Superior water maze performance and increase in fear-related behavior in the endothelial nitric oxide synthase-deficient mouse together with monoamine changes in cerebellum and ventral striatum

J. Neurosci. 20, 6694-6700. 

Brandes R.P., Schmitz-Winnenthal F.H., Feletou M., Gödecke A., Huang P.L., Vanhoutte P.M., Fleming I.,

Busse R. (2000).

An endothelium-derived hyperpolarizing factor distinct from NO and prostacyclin is a major endothelium-dependent vasodilator in resistance vessels of wild-type and endothelial NO synthase knockout mice.

Proc. Natl. Acad. Sci. U. S. A 97, 9747-9752. 

Wagner C., Gödecke A., Ford M., Schnermann J., Schrader J., Kurtz A. (2000)

Regulation of renin gene expression in kidneys of.

Pflugers Arch. 439, 567-572. 

Todorov V., Gess B., Gödecke A., Wagner C., Schrader J., Kurtz A. (2000)

Endogenous nitric oxide attenuates erythropoietin gene expression in vivo.

Pflugers Arch. 439, 445-448. 

Brandes R.P., Kim D., Schmitz-Winnenthal F.H., Amidi M., Gödecke A., Mülsch A., Busse R. (2000)

Increased nitrovasodilator sensitivity in endothelial nitric oxide synthase knockout mice: role of soluble guanylyl cyclase.

Hypertension 35, 231-236. 

Gödecke A., Flögel U., Zanger K., Ding Z., Hirchenhain J., Decking U.K., Schrader J. (1999)

Disruption of myoglobin in mice induces multiple compensatory mechanisms.

Proc. Natl. Acad. Sci. U. S. A 96, 10495-10500. 

Stauss H.M.,Gödecke A., Mrowka R., Schrader J., Persson P.B. (1999)

Enhanced blood pressure variability in eNOS knockout mice.

Hypertension 33, 1359-1363. 

Wilson R.I., Gödecke A., Brown R.E., Schrader J., Haas H.L. (1999)

Mice deficient in endothelial nitric oxide synthase exhibit a selective deficit in hippocampal long-term potentiation.

Neuroscience 90, 1157-1165. 

Flögel U., Decking U.K., Gödecke A., Schrader J. (1999)

Contribution of NO to ischemia-reperfusion injury in the saline- perfused heart: a study in endothelial NO synthase knockout mice.

J. Mol. Cell Cardiol. 31, 827-836. 

Haul S., Gödecke A., Schrader J., Haas H.L., Luhmann H.J. (1999)

Impairment of neocortical long-term potentiation in mice deficient of endothelial nitric oxide synthase.

J. Neurophysiol. 81, 494-497. 

Kupatt C., Habazettl H., Gödecke A., Wolf D.A., Zahler S., Boekstegers P., Kelly R.A., Becker B.F. (1999)

Tumor necrosis factor-alpha contributes to ischemia- and reperfusion- induced endothelial activation in isolated hearts.

Circ. Res. 84, 392-400. 

Herrmann A., Muller G., Gödecke A., Schrader J. (1998)

Recombination of nonreplicative RNA precursors of Sindbis virus in infected cells overexpressing murine-inducible nitric oxide synthase.

Biochem. Biophys. Res. Commun. 253, 524-531. 

Gödecke A., Decking U.K., Ding Z., Hirchenhain J., Bidmon H.J., Gödecke S., Schrader J. (1998)

Coronary hemodynamics in endothelial NO synthase knockout mice.

Circ. Res. 82, 186-194. 

Bidmon H.J., Wu J., Gödecke A., Schleicher A., Mayer B., Zilles K. (1997)

Nitric oxide synthase-expressing neurons are area-specifically distributed within the cerebral cortex of the rat.

Neuroscience 81, 321-330. 

Wilson R.I., Yanovsky J., Gödecke A., Stevens D.R., Schrader J., Haas H.L. (1997)

Endothelial nitric oxide synthase and LTP.

Nature 386, 338. 

Gödecke S., Decking U.K., Gödecke A., Schrader J. (1996)

Cloning of the rat P2u receptor and its potential role in coronary vasodilation.

Am. J. Physiol 270, C570-C577. 

Decking U.K., Flesche C.W., Gödecke A., Schrader J. (1995)

Endotoxin-induced contractile dysfunction in guinea pig hearts is not mediated by nitric oxide.

Am. J. Physiol 268, H2460-H2465. 

Sonnenberg E., Gödecke A., Walter B., Bladt F., Birchmeier C. (1991)

Transient and locally restricted expression of the ros1 protooncogene during mouse development.

EMBO J. 10, 3693-3702. 

Gödecke A., Zachariae W., Arvanitidis A., Breunig K.D. (1991)

Coregulation of the Kluyveromyces lactis lactose permease and beta- galactosidase genes is achieved by interaction of multiple LAC9 binding sites in a 2.6 kbp divergent promoter.

Nucleic Acids Res. 19, 5351-5358. 

Kuger P., Gödecke A., Breunig K.D. (1990)

A mutation in the Zn-finger of the GAL4 homolog LAC9 results in glucose repression of its target genes.

Nucleic Acids Res. 18, 745-751. 

Gödecke A., Veenhuis M., Roggenkamp R., Janowicz Z.A., Hollenberg C.P. (1989)

Biosynthesis of the peroxisomal dihydroxyacetone synthase from Hansenula polymorpha in Saccharomyces cerevisiae induces growth but not proliferation of peroxisomes.

Curr. Genet. 16, 13-20. 

Übersichtsarbeiten 

Gödecke A., Schrader J. (2000)

Adaptive mechanisms of the cardiovascular system in transgenic mice-- lessons from eNOS and myoglobin knockout mice.

Basic Res. Cardiol. 95, 492-498 

Gödecke A., Schrader J. (1993)

Transgene Tiere- Herausforderung an die integrative Physioloie.

Physiologie 1, 16-22. 

Hollenberg C.P., Janowicz Z., Eckart M., Garg P., Gödecke A., Roggenkamp R. (1987)

Molecular genetics of methylotrophic yeasts.

Antonie Van Leeuwenhoek 53, 365.