Publikationen

2024

Mann J., Niedermayer K., Krautstrunk J., Abbey L., Wiesmüller L., Piekorz R.P., Fritz G. Combined inhibition of RAD51 and CHK1 causes synergistic toxicity in cisplatin resistant cancer cells by triggering replication fork collapse. Int J Cancer. 2024 Sep 6. doi: 10.1002/ijc.35164

Schmitt L., Hoppe J., Cea-Medina P., Bruch P.-M., Krings K.S., Lechtenberg I., Drießen D., Peter C., Bhatia S., Dietrich S., Stork B., Fritz G., Gohlke H., Müller T.J.J., Wesselborg S. Novel meriolin derivatives potently inhibit cell cycle progression and transcription in leukemia and lymphoma cells via inhibition of cyclin-dependent kinases (CDKs). Cell Death Discov. 2024; 10: 279. Published online 2024 Jun 11. doi: 10.1038/s41420-024-02056-6; PMCID: PMC11167047; PMID: 38862521

Schmitt L., Lechtenberg I., Drießen D., Flores-Romero H., Skowron M.A., Sekeres M., Hoppe J., Krings K.S., Llewellyn T.R., Peter C., Stork B., Qin N., Bhatia S., Nettersheim D., Fritz G., García-Sáez A.J., Müller T.J.J., Wesselborg S. Novel meriolin derivatives activate the mitochondrial apoptosis pathway in the presence of antiapoptotic Bcl-2. Cell Death Discov. 2024 Mar 9;10(1):125. doi: 10.1038/s41420-024-01901-y. PMID: 38461295 PMCID: PMC10924942

Kücük P., Abbey L., Schmitt J., Henninger C., Fritz G. Cardiomyocytes, cardiac endothelial cells and fibroblasts contribute to anthracycline-induced cardiac injury through RAS-homologous small GTPases RAC1 and CDC42. Pharmacol Res. 2024 Mar 30:107165. doi: 10.1016/j.phrs.2024.107165. PMID: 38561112

2023

Mboni-Johnston I.M., Kouidrat N.M.Z., Hirsch C., Weber A.G., Meißner A., Adjaye J., Schupp N. Sensitivity of Human Induced Pluripotent Stem Cells and Thereof Differentiated Kidney Proximal Tubular Cells towards Selected Nephrotoxins. Int J Mol Sci. 2023 Dec 20;25(1):81. doi: 10.3390/ijms25010081. PMID: 38203251 PMCID: PMC10779191

Wynen F., Krautstrunk J., Müller S.M., Graf V., Brinkmann V., Fritz G. Cisplatin-induced DNA crosslinks trigger neurotoxicity in C. elegans. Biochim Biophys Acta Mol Cell Res. 2024 Jan;1871(1):119591. doi: 10.1016/j.bbamcr.2023.119591. Epub 2023 Sep 18.

Kreutzmann M., Kraus B.J., Christa M., Störk S., Jansen E.H.J.M., Stopper H., Schupp N. Differential Modulation of Markers of Oxidative Stress and DNA Damage in Arterial Hypertension. Antioxidants (Basel). 2023 Nov 4;12(11):1965. doi: 10.3390/antiox12111965. PMID: 38001818 PMCID: PMC10669810

Brinks R., Wruck J.W., Schmitz J., Schupp N. Nrf2 Activation Does Not Protect from Aldosterone-Induced Kidney Damage in Mice. Antioxidants 2023, 12(3), 777; doi.org/10.3390/antiox12030777

2022

Kitzinger R., Fritz G., Henninger C. Nuclear RAC1 is a modulator of the doxorubicin-induced DNA damage response. Biochim Biophys Acta Mol Cell Res. 2022 Jul 8;1869(10):119320. PMID: 35817175 DOI: 10.1016/j.bbamcr.2022.119320.

Aengenvoort J., Sekeres M., Proksch P., Fritz G. Targeting Mechanisms of the DNA Damage Response (DDR) and DNA Repair by Natural Compounds to Improve cAT-Triggered Tumor Cell DeathMolecules. 2022 Jun 1;27(11):3567. PMID: 35684504 PMCID: PMC9182506 DOI: 10.3390/molecules27113567.

Brinkmann V., Fritz G. Prevention of anticancer therapy-induced neurotoxicity: putting DNA damage in perspective. Neurotoxicology. 2022 Apr 26;S0161-813X(22)00057-2. doi: 10.1016/j.neuro.2022.04.009. PMID: 35487345.

Hanisch D., Krumm A., Diehl T., Stork C.M., Dejung M., Butter F., Kim E., Brenner W., Fritz G., Hofmann T.G., Roos W.P. Class I HDAC overexpression promotes temozolomide resistance in glioma cells by regulating RAD18 expression. Cell Death Dis. 2022 Apr 1;13(4):293. doi: 10.1038/s41419-022-04751-7.

Martínez-Fernández C., Bergamino M., Schiavi A., Brena D., Ventura N., Honnen S., Villanueva A., Nadal E., Cerón J. Insights into cisplatin-induced neurotoxicity and mitochondrial dysfunction in Caenorhabditis elegans. Disease Models & Mechanisms, 02 Feb 2022, DOI: 10.1242/dmm.049161 PMID: 35107130.

2021

Wellenberg A., Brinkmann V., Bornhorst J., Ventura N., Honnen S., Fritz G. Cisplatin-induced neurotoxicity involves the disruption of serotonergic neurotransmission. Pharmacol Res. 2021 Sep 30;105921. doi: 10.1016/j.phrs.2021.105921.

Nicolai M.N., Weishaupt A., Baesler J., Brinkmann V., Wellenberg A., Winkelbeiner N., Gremme A., Aschner M., Fritz G., Schwerdtle T., Bornhorst J. Effects of Manganese on Genomic Integrity in the Multicellular Model Organism Caenorhabditis elegansInt. J. Mol. Sci. 2021, 22(20), 10905; doi.org/10.3390/ijms222010905.

Schürmann L., Schumacher L., Roquette K., Brozovic A., Fritz G. Inhibition of the DSB repair protein RAD51 potentiates the cytotoxic efficacy of doxorubicin via promoting apoptosis-related death pathways. Cancer Lett. 2021 Aug 10;S0304-3835(21)00395-5. doi: 10.1016/j.canlet.2021.08.006.

Wellenberg  A., Weides L., Kurzke J., Hennecke T., Bornhorst J., Crone B., Karst U., Brinkmann V., Fritz G., Honnen S. Use of C. elegans as a 3R-compliant in vivo model for the chemoprevention of cisplatin-induced neurotoxicity. Exp Neurol. 2021 Jul;341:113705. doi: 10.1016/j.expneurol.2021.113705. Epub 2021 Mar 20.

2020

Büchter C., Koch K., Freyer M., Baier S., Saier C., Honnen S., Wätjen W. The mycotoxin beauvericin impairs development, fertility and life span in the nematode Caenorhabditis elegans accompanied by increased germ cell apoptosis and lipofuscin accumulation. Toxicology Letters, Volume 334, 1 November 2020, Pages 102-109; doi.org/10.1016/j.toxlet.2020.09.016.

Balhorn R., Hartmann C., Schupp N. Aldosterone Induces DNA Damage and Activation of Nrf2 Mainly in Tubuli of Mouse Kidneys. Int J Mol Sci. 2020 Jun 30;21(13):E4679.doi: 10.3390/ijms21134679.

Friedrich A., Assmann A., Schumacher L., v. Stuijvenberg J., Kassack M., Schulz W., Roos W.P., Hansen F., Pflieger M., Kurz T. and Fritz G.In Vitro Assessment of the Genotoxic Hazard of Novel Hydroxamic Acid- and Benzamide-Type Histone Deacetylase Inhibitors (HDACi). Int. J. Mol. Sci. 2020, 21(13), 4747; doi.org/10.3390/ijms21134747.

Zimnol A., Spicker N., Balhorn R., Schröder K., Schupp N. The NADPH Oxidase Isoform 1 Contributes to Angiotensin II-Mediated DNA Damage in the Kidney. Antioxidants (Basel); PMID: 32635630 DOI: 10.3390/antiox9070586.

Jahn S.K., Hennicke T., Kassack M., Drews L., Reichert A.S., Fritz G. Distinct Influence of the Anthracycline Derivative Doxorubicin on the Differentiation Efficacy of mESC-derived Endothelial Progenitor Cells. Biochim Biophys Acta Mol Cell Res. 2020 Mar 26;118711. doi: 10.1016/j.bbamcr.2020.118711.

Ziegler V., Deußen M., Schumacher L., Roos W.P., Fritz G. Anticancer drug and ionizing radiation-induced DNA damage differently influences transcription activity and DDR-related stress responses of an endothelial monolayer. Biochim Biophys Acta Mol Cell Res. 2020 Feb 14;1867(6):118678. doi: 10.1016/j.bbamcr.2020.118678.

van Stuijvenberg J., Proksch P., Fritz G. Targeting the DNA damage response (DDR) by natural compounds. Bioorganic & Medicinal Chemistry. Volume 28, Issue 4, 15 February 2020, 115279.

Jahn A., Scherer B., Fritz G., Honnen S. Statins Induce a DAF-16/Foxo-dependent Longevity Phenotype via JNK-1 through Mevalonate Depletion in C. elegans. Aging Dis. 2020 Feb 1;11(1):60-72. doi: 10.14336/AD.2019.0416. eCollection 2020 Feb.

2019

Purinergic Signal. 2019 Sep;15(3):287-298. doi: 10.1007/s11302-019-09663-4. Epub 2019 Jul 3. Profiling of a suramin-derived compound library at recombinant human P2Y receptors identifies NF272 as a competitive but non-selective P2Y2 receptor antagonist. Brockmann N, Sureechatchaiyan P, Müller D, Hennicke T, Hausmann R, Fritz G, Hamacher A, Kassack MU.

Arch Toxicol. 2019 Jul;93(7):2045-2055. doi: 10.1007/s00204-019-02477-8. Epub 2019 May 16. Angiotensin II-induced hypertension increases the mutant frequency in rat kidney. Hartmann C, Schulz I, Epe B, Schupp N.

Sci Rep. 2019 Sep 24;9(1):13800. doi: 10.1038/s41598-019-49953-w. Human primary endothelial cells are impaired in nucleotide excision repair and sensitive to benzo[a]pyrene compared with smooth muscle cells and pericytes. Kress JM, Dio LD, Heck L, Pulliero A, Izzotti A, Laarmann K, Fritz G, Kaina B.

DNA Repair (Amst). 2019 Jan;73:17-27. doi: 10.1016/j.dnarep.2018.10.005. Epub 2018 Oct 28. Werner syndrome (WRN) DNA helicase and base excision repair (BER) factors maintain endothelial homeostasis. Laarmann K, Kress JM, Kaina B, Fritz G.

Naunyn Schmiedebergs Arch Pharmacol. 2019 Sep 9. doi: 10.1007/s00210-019-01719-x. Effect of infliximab, a tumor necrosis factor-alpha inhibitor, on doxorubicin-induced nephrotoxicity in rats. Abdelrahman AM, Al Suleimani YM, Manoj P, Ashique M, Ali BH, Schupp N.

Biochemical Pharmacology, Volume 164, June 2019, Pages 82-93. Distinct contribution of Rac1 expression in cardiomyocytes to anthracycline-induced cardiac injury. Henninger C, Pohlmann S, Ziegler V, Ohlig J, Schmitt J, Fritz G

Cell Physiol Biochem 2019;52:263-275; DOI: 10.1159/000496597. Effects of the SGLT-2 Inhibitor Canagliflozin on Adenine-Induced Chronic Kidney Disease in Rats. Ali BH, Al Salam S, Al Suleimani Y, Al Za’abi M, Abdelrahman AM, Ashique M, Manoj P, Adham SA, Hartmann C, Schupp N, Nemmar A

2018

Basic Clin Pharmacol Toxicol. 2018 Jan;122(1):65-73. doi: 10.1111/bcpt.12817. Epub 2017 Jul 10. Curcumin Ameliorates Kidney Function and Oxidative Stress in Experimental Chronic Kidney Disease. Ali BH, Al-Salam S, Al Suleimani Y, Al Kalbani J, Al Bahlani S, Ashique M, Manoj P, Al Dhahli B, Al Abri N, Naser HT, Yasin J, Nemmar A, Al Za'abi M, Hartmann C, Schupp N.

Biochim Biophys Acta Mol Cell Res. 2018 Sep;1865(9):1277-1292. doi: 10.1016/j.bbamcr.2018.06.007. Epub 2018 Jun 20. Hepatic Rac1 GTPase contributes to liver-mediated basal immune homeostasis and LPS-induced endotoxemia. Pohlmann S, Scheu S, Ziegler V, Schupp N, Henninger C, Fritz G.

Cancer Lett. 2018 Aug 28;430:34-46. doi: 10.1016/j.canlet.2018.05.011. Epub 2018 May 16. Multiple DNA damage-dependent and DNA damage-independent stress responses define the outcome of ATR/Chk1 targeting in medulloblastoma cells. Krüger K, Geist K, Stuhldreier F, Schumacher L, Blümel L, Remke M, Wesselborg S, Stork B, Klöcker N, Bormann S, Roos WP, Honnen S, Fritz G.

DNA Repair (Amst). 2019 Jan;73:17-27. doi: 10.1016/j.dnarep.2018.10.005. Epub 2018 Oct 28. Werner syndrome (WRN) DNA helicase and base excision repair (BER) factors maintain endothelial homeostasis. Laarmann K, Kress JM, Kaina B, Fritz G.

Biomed Pharmacother. 2018 Dec 12;110:667-676. doi: 10.1016/j.biopha.2018.11.117. [Epub ahead of print] The renoprotective effect of the dipeptidyl peptidase-4 inhibitor sitagliptin on adenine-induced kidney disease in rats. Abdelrahman AM, Suleimani YA, Za'abi MA, Ashique M, Manoj P, Hartmann C, Nemmar A, Schupp N, Ali BH.

Dis Model Mech. 2018 Jun 21;11(6). pii: dmm033506. doi: 10.1242/dmm.033506. Genetic and cellular sensitivity of Caenorhabditis elegans to the chemotherapeutic agent cisplatin. García-Rodríguez FJ, Martínez-Fernández C, Brena D, Kukhtar D, Serrat X, Nadal E, Boxem M, Honnen S, Miranda-Vizuete A, Villanueva A, Cerón J.

EMBO Rep. 2018 Dec;19(12). pii: e45856. doi: 10.15252/embr.201845856. Epub 2018 Oct 26. BRCA1 and BARD1 mediate apoptotic resistance but not longevity upon mitochondrial stress in Caenorhabditis elegans. Torgovnick A, Schiavi A, Shaik A, Kassahun H, Maglioni S, Rea SL, Johnson TE, Reinhardt HC, Honnen S, Schumacher B, Nilsen H, Ventura N.

2017

Ohlig J, Henninger C, Zander S, Merx M, Kelm M, Fritz G. Rac1-mediated cardiac damage causes diastolic dysfunction in a mouse model of subacute doxorubicin-induced cardiotoxicity. Arch Toxicol. 2017 Jul 14. doi: 10.1007/s00204-017-2017-7

Ziegler V, Henninger C, Simiantonakis I, Buchholzer M, Ahmadian MR, Budach W, Fritz G. Rho inhibition by lovastatin affects apoptosis and DSB repair of primary human lung cells in vitro and lung tissue in vivo following fractionated irradiation. Cell Death Dis. 2017 Aug 10;8(8):e2978. doi: 10.1038/cddis.2017.372.

Zimnol A, Amann K, Mandel P, Hartmann C, Schupp N. Angiotensin II type 1a receptor-deficient mice develop angiotensin II-induced oxidative stress and DNA damage without blood pressure increase. Am J Physiol Renal Physiol. 2017 Dec 1;313(6):F1264-F1273. doi: 10.1152/ajprenal.00183.2017. Epub 2017 Sep 6

Queisser N, Schupp N, Schwarz E, Hartmann C, Mackenzie GG, Oteiza PI. Aldosterone activates the oncogenic signals ERK1/2 and STAT3 via redox-regulated mechanisms. Mol Carcinog. 2017 Mar 8. doi: 10.1002/mc.22643. [Epub ahead of print]

Honnen S. Caenorhabditis elegans as a powerful alternative model organism to promote research in genetic toxicology and biomedicine. Arch Toxicol. 2017 Mar 15. doi: 10.1007/s00204-017-1944-7.

Jansen E, Beekhof P, Schupp N, Kreutzmann M, Kraus B. A Comparison Between Two Assays for the Redox Status in Plasma. J Anal Bioanal Tech 2017, 8:1; DOI: 10.4172/2155-9872.1000342

Henninger C, Fritz G. Statins in anthracycline-induced cardiotoxicity: Rac and Rho, and the heartbreakers. Cell Death Dis. 2017 Jan 19;8(1):e2564. doi: 10.1038/cddis.2016.418.

2016

Daschkey S, Bienemann K, Schuster V, Kreth HW, Linka RM, Hönscheid A, Fritz G, Johannes C, Fleckenstein B, Kempkes B, Gombert M, Ginzel S, Borkhardt A. Fatal Lymphoproliferative Disease in Two Siblings Lacking Functional FAAP24. J Clin Immunol. 2016 Jul 29.

Schupp N, Stopper H and Heidland A. DNA Damage in Chronic Kidney Disease: Evaluation of Clinical Biomarkers. Oxidative Medicine and Cellular Longevity. Volume 2016 (2016), Article ID 3592042, 10 pages

Höhn A, Krüger K, Skowron MA, Bormann S, Schumacher L, Schulz WA, Hoffmann MJ, Niegisch G, Fritz G. Distinct mechanisms contribute to acquired cisplatin resistance of urothelial carcinoma cells. Oncotarget. 2016 May 12. doi: 10.18632/oncotarget.9321. [Epub ahead of print]

Stojanovic N, Brozovic A, Majhen D, Bosnar MH, Fritz G, Osmak M, Ambriovic-Ristov A. Integrin ?v?3 expression in tongue squamous carcinoma cells Cal27 confers anticancer drug resistance through loss of pSrc(Y418). Biochim Biophys Acta. 2016 Apr 21. pii: S0167-4889(16)30119-7. doi: 10.1016/j.bbamcr.2016.04.019. [Epub ahead of print]

Busch CJ, Becker B, Kriegs M, Gatzemeier F, Krüger K, Möckelmann N, Fritz G, Petersen C, Knecht R, Rothkamm K, Rieckmann T. Similar cisplatin sensitivity of HPV-positive and -negative HNSCC cell lines. Oncotarget. 2016 Apr 26. doi: 10.18632/oncotarget.9028. [Epub ahead of print]

Atreya I, Diall A, Dvorsky R, Atreya R, Henninger C, Grün M, Hofmann U, Schaeffeler E, López-Posadas R, Daehn I, Zenker S, Döbrönti M, Neufert C, Billmeier U, Zundler S, Fritz G, Schwab M, Neurath MF. Designer thiopurine-analogues for optimized immunosuppression in inflammatory bowel diseases. J Crohns Colitis. 2016 Apr 25. pii: jjw091. [Epub ahead of print]

Ziegler V, Albers A, Fritz G. Lovastatin protects keratinocytes from DNA damage-related pro-apoptotic stress responses stimulated by anticancer therapeutics. Biochim Biophys Acta. 2016 Feb 12;1863(6 Pt A):1082-1092. doi: 10.1016/j.bbamcr.2016.02.009.

Ali BH, Al Za'abi M, Adham SA, Yasin J, Nemmar A, Schupp N. Therapeutic Effect of Chrysin on Adenine-Induced Chronic Kidney Disease in Rats. Cell Physiol Biochem. 2016 Jan 20;38(1):248-257. [Epub ahead of print]

2015

Skowron MA, Niegisch G, Fritz G, Arent T, van Roermund JG, Romano A, Albers P, Schulz WA, Hoffmann MJ. Phenotype plasticity rather than repopulation from CD90/CK14+ cancer stem cells leads to cisplatin resistance of urothelial carcinoma cell lines. J Exp Clin Cancer Res. 2015 Nov 25;34:144. doi: 10.1186/s13046-015-0259-x.

Krüger K, Ziegler V, Hartmann C, Henninger C, Thomale J, Schupp N, Fritz G. Lovastatin prevents cisplatin-induced activation of pro-apoptotic DNA damage response (DDR) of renal tubular epithelial cells. Toxicol Appl Pharmacol. 2015 Dec 28. pii: S0041-008X(15)30169-1. doi: 10.1016/j.taap.2015.12.023. [Epub ahead of print]

Ali BH, Al Balushi K, Al-Husseni I, Mandel P, Nemmar A, Schupp N, Ribeiro DA. Gum acacia mitigates genetic damage in adenine-induced chronic renal failure in rats. Eur J Clin Invest. 2015 Jul 17. doi: 10.1111/eci.12501.

Fritz G und Henninger C. Rho GTPases: Novel Players in the Regulation of the DNA Damage Response? Biomolecules. 2015 Sep 30;5(4):2417-34. doi: 10.3390/biom5042417

Büchter C, Ackermann D, Honnen S, Arnold N, Havermann S, Koch K and Wätjen W. Methylated derivatives of myricetin enhance life span in Caenorhabditis elegans dependent on the transcription factor DAF-16. Food Funct., 2015, DOI: 10.1039/C5FO00463B

Büchter C, Zhao L, Havermann S, Honnen S, Fritz G, Proksch P and Wätjen W. TSG (2,3,5,4'-Tetrahydroxystilbene-2-O-?-D-glucoside) from the Chinese Herb Polygonum multiflorum Increases Life Span and Stress Resistance of Caenorhabditis elegans. Oxidative Medicine and Cellular Longevity, vol. 2015, Article ID 124357, 12 pages, 2015. doi:10.1155/2015/124357

Ali BH, Adham SA, Al Za'abi M, Waly MI, Yasin J, Nemmar A, Schupp N. Ameliorative Effect of Chrysin on Adenine-Induced Chronic Kidney Disease in Rats. PLoS One. 2015 Apr 24;10(4):e0125285. doi: 10.1371/journal.pone.0125285.

Liedtke S, Biebernick S, Radke TF, Stapelkamp D, Coenen C, Zaehres H, Fritz G, Kogler G. DNA Damage Response in Neonatal and Adult Stromal Cells Compared With Induced Pluripotent Stem Cells. Stem Cells Transl Med. 2015 Apr 21. pii: sctm.2014-0209. [Epub ahead of print]

Stuhldreier F, Kassel S, Schumacher L, Wesselborg S, Proksch P, Fritz G. Pleiotropic effects of spongean alkaloids on mechanisms of cell death, cell cycle progression and DNA damage response (DDR) of acute myeloid leukemia (AML) cells. Cancer Lett. 2015 May 28;361(1):39-48. doi: 10.1016/j.canlet.2015.02.030. Epub 2015 Feb 16.

Krüger K, Thomale J, Stojanovic N, Osmak M, Henninger C, Bormann S, Fritz G. Platinum-induced kidney damage: Unraveling the DNA damage response (DDR) of renal tubular epithelial and glomerular endothelial cells following platinum injury. Biochim Biophys Acta. 2015 Jan 4. pii: S0167-4889(14)00468-6. doi: 10.1016/j.bbamcr.2014.12.033. [Epub ahead of print], PMID: 25565603

Bopp A, Wartlick F, Henninger C, Schwarz M, Kaina B, Fritz G. Rac1 promotes diethylnitrosamine (DEN)-induced formation of liver tumors. Carcinogenesis. 2015 Jan 2. pii: bgu323. [Epub ahead of print], PMID: 25556150

Hennicke T, Nieweg K, Brockmann N, Kassack MU, Gottmann K, Fritz G. mESC-based in vitro differentiation models to study vascular response and functionality following genotoxic insults. Toxicol Sci. 2015 Mar;144(1):138-50. doi: 10.1093/toxsci/kfu264. Epub 2014 Dec 15., PMID: 25516496

Henninger C, Huelsenbeck S, Wenzel P, Brand M, Huelsenbeck J, Schad A, Fritz G. Chronic heart damage following doxorubicin treatment is alleviated by lovastatin. Pharmacol Res. 2015 Jan;91:47-56. doi: 10.1016/j.phrs.2014.11.003. Epub 2014 Nov 21

2014

Brand S, Amann K, Mandel P, Zimnol A, Schupp N. Oxidative DNA Damage in Kidneys and Heart of Hypertensive Mice Is Prevented by Blocking Angiotensin II and Aldosterone Receptors. PLoS One. 2014 Dec 31;9(12):e115715. doi: 10.1371/journal.pone.0115715. eCollection 2014, PMID: 25551569

Honnen S, Bossinger O, Hoffmann M. PLANAR CELL POLARITY PROTEINS VANG-1 AND DSH-2 CONTRIBUTE TO JNK-1 ACTIVATION IN C. ELEGANS EMBRYOGENESIS. Asian Journal of Science and Technology 11/2014 5(11):665-668

Havermann S, Chovolou Y, Humpf HU, Wätjen W. Caffeic acid phenethylester increases stress resistance and enhances lifespan in Caenorhabditis elegans by modulation of the insulin-like DAF-16 signalling pathway. PLoS One. 2014 Jun 25;9(6):e100256. doi: 10.1371/journal.pone.0100256. eCollection 2014.

Queisser N, Happ K, Link S, Jahn D, Zimnol A, Geier A, Schupp N. Aldosterone induces fibrosis, oxidative stress and DNA damage in livers of male rats independent of blood pressure changes. Toxicol Appl Pharmacol. 2014 Sep 7. pii: S0041-008X(14)00321-4. PMID: 25204689

Funk F, Krüger K, Henninger C, Wätjen W, Proksch P, Thomale J, Fritz G. Spongean alkaloids protect rat kidney cells against cisplatin-induced cytotoxicity. Anticancer Drugs. Anticancer Drugs. 2014 Sep;25(8):917-29. PMID: 24820908

Wätjen W, Debbab A, Hohlfeld A, Chovolou Y, Proksch P. The mycotoxin beauvericin induces apoptotic cell death in H4IIE hepatoma cells accompanied by an inhibition of NF-?B-activity and modulation of MAP-kinases. Toxicol Lett. 2014 Nov 18;231(1):9-16. doi: 10.1016/j.toxlet.2014.08.021. Epub 2014 Aug 29.

Fahrer J, Huelsenbeck J, Jaurich H, Dörsam B, Frisan T, Eich M, Roos WP, Kaina B, Fritz G. Cytolethal distending toxin (CDT) is a radiomimetic agent and induces persistent levels of DNA double-strand breaks in human fibroblasts. DNA Repair, Available online 25 March 2014, ISSN 1568-7864, dx.doi.org/10.1016/j.dnarep.2014.03.002.

2013

Brozovic A, Vukovic L, Polancac DS, Arany I, Köberle B, Fritz G, Fiket Z, Majhen D, Ambriovic-Ristov A, Osmak M. Endoplasmic Reticulum Stress Is Involved in the Response of Human Laryngeal Carcinoma Cells to Carboplatin but Is Absent in Carboplatin-Resistant Cells. PLoS One. 2013 Sep 23;8(9):e76397.

Limper C, Wang Y, Ruhl S, Wang Z, Lou Y, Totzke F, Kubbutat MH, Chovolou Y, Proksch P, Wätjen W. Compounds isolated from Psoralea corylifolia seeds inhibit protein kinase activity and induce apoptotic cell death in mammalian cells. J Pharm Pharmacol. 2013 Sep;65(9):1393-408. doi: 10.1111/jphp.12107. Epub 2013 Jul 31.

Wartlick F, Bopp A, Henninger C, Fritz G. DNA damage response (DDR) induced by topoisomerase II poisons requires nuclear function of the small GTPase Rac. Biochim Biophys Acta. 2013 Aug 30;1833(12):3093-3103. doi: 10.1016/j.bbamcr.2013.08.016. [Epub ahead of print]

Huelsenbeck SC, Roggenkamp D, May M, Huelsenbeck J, Brakebusch C, Rottner K, Ladwein M, Just I, Fritz G, Schmidt G, Genth H. Expression and cytoprotective activity of the small GTPase RhoB induced by the Escherichia coli cytotoxic necrotizing factor 1. Int J Biochem Cell Biol. 2013 Aug;45(8):1767-75. doi: 10.1016/j.biocel.2013.05.020. Epub 2013 May 31.

Fritz G, Kaina B Rac1 GTPase, a multifunctional player in the regulation of genotoxic stress response. Cell Cycle 2013 Jul 29; 12(16)

Büchter C, Ackermann D, Havermann S, Honnen S, Chovolou Y, Fritz G, Kampkötter A, Wätjen W. Myricetin-Mediated Lifespan Extension in Caenorhabditis elegans Is Modulated by DAF-16. Int J Mol Sci. 2013 Jun 4;14(6):11895-914. doi: 10.3390/ijms140611895.

Hinterleitner C, Huelsenbeck J, Henninger C, Wartlick F, Schorr A, Kaina B, Fritz G. Rac1 signaling protects monocytic AML cells expressing the MLL-AF9 oncogene from caspase-mediated apoptotic death. Apoptosis. 2013 Aug;18(8):963-79. doi: 10.1007/s10495-013-0842-6.

Bopp A, Wartlick F, Henninger C, Kaina B, Fritz G. Rac1 modulates acute and subacute genotoxin-induced hepatic stress responses, fibrosis and liver aging. Cell Death Dis. 2013 Mar 21;4:e558. doi: 10.1038/cddis.2013.57.

Hamed AN, Wätjen W, Schmitz R, Chovolou Y, Edrada-Ebel R, Youssef DT, Kamel MS, Proksch P. A new bioactive sesquiterpenoid quinone from the Mediterranean Sea marine sponge Dysidea avara. Nat Prod Commun. 2013 Mar;8(3):289-92.

Havermann S, Rohrig R, Chovolou Y, Humpf HU, Wätjen W. Molecular effects of baicalein in Hct116 cells and Caenorhabditis elegans : activation of the Nrf2 signaling pathway and prolongation of lifespan. J Agric Food Chem. 2013 Mar 6;61(9):2158-64. doi: 10.1021/jf304553g. Epub 2013 Feb 21.

2012

Huelsenbeck J, May M, Schulz F, Schelle I, Ronkina N, Hohenegger M, Fritz G, Just I, Gerhard R, Genth H. Cytoprotective effect of the small GTPase RhoB expressed upon treatment of fibroblasts with the Ras-glucosylating Clostridium sordellii lethal toxin. FEBS Lett. 2012 Oct 19;586(20):3665-73. doi: 10.1016/j.febslet.2012.08.024. Epub 2012 Sep 11.

Huelsenbeck SC, Schorr A, Roos WP, Huelsenbeck J, Henninger C, Kaina B, Fritz G. Rac1 signaling is required for DNA damage response stimulated by topoisomerase II poisons. J Biol Chem. 2012 Sep 25. [Epub ahead of print]

Henninger C, Huelsenbeck J, Huelsenbeck S, Grösch S, Schad A, Lackner KJ, Kaina B, Fritz G. The lipid lowering drug lovastatin protects against doxorubicin-induced hepatotoxicity. Toxicol Appl Pharmacol. 2012 May 15;261(1):66-73.

Honnen SJ, Büchter C, Schröder V, Hoffmann M, Kohara Y, Kampkötter A, Bossinger O. C. elegans VANG-1 Modulates Life Span via Insulin/IGF-1-Like Signaling.  PLoS One. 2012;7(2):e32183. Epub 2012 Feb 16.

Döhrmann M, Schorr A, Hülsenbeck J, Rasmussen TL, Issinger OG, Fritz G. Comparative analysis of stress responses of H9c2 rat cardiomyoblasts following treatment with doxorubicin and tBOOH. Exp Cell Res. 2012 Jan 13

Hoffmann M, Honnen S, Mayatepek E, Wätjen W, Koopman WJ, Bossinger O, Distelmaier F. MICS-1 interacts with mitochondrial ATAD-3 and modulates lifespan in C. elegans. Exp Gerontol. 2012 Mar;47(3):270-5. Epub 2012 Jan 5.

2011

Hamalukic M, Huelsenbeck J, Schad A, Wirtz S, Kaina B, Fritz G. Rac1-regulated endothelial radiation response stimulates extravasation and metastasis that can be blocked by HMG-CoA reductase inhibitors. PLoS One. 2011;6(10):e26413. Epub 2011 Oct 19.

Huelsenbeck J, Henninger C, Schad A, Lackner KJ, Kaina B, Fritz G. Inhibition of Rac1 signaling by lovastatin protects against anthracycline-induced cardiac toxicity. Cell Death Dis. 2011 Aug 11;2:e190. doi: 10.1038/cddis.2011.65.

Chovolou Y, Ebada SS, Wätjen W, Proksch P. Identification of angular naphthopyrones from the Philippine echinoderm Comanthus species as inhibitors of the NF-?B signaling pathway. Eur J Pharmacol. 2011, 657, 26-34

Wetzel C, Kunz PC, Kassack MU, Hamacher A, Böhler P, Watjen W, Ott I, Rubbiani R, Spingler B. Gold(I) complexes of water-soluble diphos-type ligands: synthesis, anticancer activity, apoptosis and thioredoxin reductase inhibition. Dalton Trans. 2011 Sep 28;40(36):9212-20. Epub 2011 Aug 9.

Olsen BB, Fritz G, Issinger OG. Characterization of ATM and DNA-PK wild-type and mutant cell lines upon DSB induction in the presence and absence of CK2 inhibitors. Int J Oncol. 2012 Feb;40(2):592-8. doi: 10.3892/ijo.2011.1227. Epub 2011 Oct 12.

2010

Lüpertz R, Wätjen W, Kahl R, Chovolou Y. Dose- and time-dependent effects of doxorubicin on cytotoxicity, cell cycle and apoptotic cell death in human colon cancer cells. Toxicology. 2010 271, 115-21

2009

Wätjen W, Putz A, Chovolou Y, Kampkötter A, Totzke F, Kubbutat MH, Proksch P, Konuklugil B. Hexa-, hepta- and nonaprenylhydroquinones isolated from marine sponges Sarcotragus muscarum and Ircinia fasciculata inhibit NF-kappaB signalling in H4IIE cells. J Pharm Pharmacol. 2009 61, 919-24.

Wätjen W*, Debbab A, Hohlfeld A, Chovolou Y, Kampkötter A, Edrada RA, Ebel R, Hakiki A, Mosaddak M, Totzke F, Kubbutat MHG, Proksch P (2009) Enniatins A1, B and B1 from an endophytic strain of Fusarium tricinctum induce apoptotic cell death in H4IIE hepatoma cells accompanied by inhibition of ERK phosphorylation, Molecular Nutrition and Food Research 2009, 10.1002/mnfr.200700428.

2008

Wätjen W, Suckow-Schnitker AK, Rohrig R, Kulawik A, Addae-Kyereme J, Wright CW, Passreiter CM. Prenylated Flavonoid Derivatives from the Bark of Erythrina addisoniae. J Nat Prod. 2008 Feb 27

Kampkötter A, Timpel C, Zurawski RF, Ruhl S, Chovolou Y, Proksch P, Wätjen W. Increase of stress resistance and lifespan of Caenorhabditis elegans by quercetin. Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology. 2008 Feb;149(2):314-23. Epub 2007 Oct 16.

Lüpertz R, Chovolou Y, Kampkötter A, Wätjen W, Kahl R. (2007) Catalase overexpression impairs TNF-alpha induced NF-kappaB activation and sensitizes MCF-7 cells against TNF-alpha. Journal of Cellular Biochemistry, 2008 Apr 1;103(5):1497-511.

Lüpertz R, Chovolou Y, Unfried K, Kampkötter A, Wätjen W, Kahl R. The forkhead transcription factor FOXO4 sensitizes cancer cells to doxorubicin mediated cytotoxicity. Carcinogenesis 2008, 29: 2045-2052.

Kampkötter A, Timpel C, Röhrdanz E, Chovolou Y, Kahl R, Wätjen W Increased expression of catalase in human hepatoma cells by the soy isoflavone daidzein. Basic & Clinical Pharmacology & Toxicology , 2008 May;102(5):437-42. Epub 2007 Nov 28.

Kampkötter A, Chovolou Y, Kulawik A, Röhrdanz E, Weber N, Proksch P, Wätjen W Isoflavone daidzein possess no antioxidant activities in cell free assays, but induces the antioxidant enzyme catalase. Nutrition Research 2008, 28: 620-8.

Kampkötter A, Wiegand C, Timpel C, Röhrdanz E, Chovolou C, Kahl R, Wätjen W Increased expression of catalase in human hepatoma cells by the soy isoflavone, daidzein. Basic & Clinical Pharmacology & Toxicology 2008, 102: 437-442.

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