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Type I Interferon protects anti-viral T cells from NK cell mediated killing.

NK cells can limit anti-viral Type I interferon receptor deficient T cells. This mechanism is critical for productive adaptive immunity. 

Xu et al. Immunity. 2014.

The protein iRhom2 triggers TNF-alpha secretion

The protein iRhom2 is involved in maturation of the TNF-alpha converting enzyme (TACE). Absence of iRhom2 results into reduced TACE activity thus reduced soluble TNF-alpha production.  

McIlwain et al. Science. 2012.

Enforced Viral Replication is critical for functional anti-viral immunity

The mechanism "enforced viral replication" describes the active amplification of viral particles in spleen tissue to guarantee sufficient antigen for adaptive immune priming. Absence of enforced viral replication results into impaired anti-viral immunity and fatal disease. 

Honke et al. Nat Immunol. 2011.

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Date: December 2022

20. Al-Salihi M, Bornikoel A, Zhuang Y, Stachura P, Scheller J, Lang KS, Lang PA. The role of ADAM17 during liver damage. Biol Chem. 2021 Jun 30;402(9):1115-1128. doi: 10.1515/hsz-2021-0149. PMID: 34192832.

19. Al-Salihi MA, Lang PA. iRhom2: An Emerging Adaptor Regulating Immunity and Disease. Int J Mol Sci. 2020 Sep;21(18):6570.

18. Liu W, Stachura P, Xu HC, Bhatia S, Borkhardt A, Lang PA, Pandyra AA. Senescent Tumor CD8+ T Cells: Mechanisms of Induction and Challenges to Immunotherapy. Cancers (Basel). 2020 Sep;12(10):2828.

17. Hamdan TA, Lang PA, Lang KS. The Diverse Functions of the Ubiquitous Fcγ Receptors and Their Unique Constituent, FcRγ Subunit. Pathogens. 2020 Feb 20;9(2):140. 

16.  Lang F, Singh Y, Salker MS, Ma K, Pandyra AA, Lang PA, Lang KS. Glucose transport in lymphocytes. Pflugers Arch. 2020 Sep;472(9):1401-1406.

15. Friedrich SK, Lang PA, Friebus-Kardash J, Duhan V, Bezgovsek J, Lang KS. Mechanisms of lymphatic system-specific viral replication and its potential role in autoimmune disease. Clin Exp Immunol. 2018 Nov 16.

14. Lang KS, Lang PA. Balancing viral replication in spleen and liver determines the outcome of systemic virus infection. Z Gastroenterol. 2015 Dec;53(12):1432-5.

13. Crouse J, Xu HC, Lang PA, Oxenius A. NK cells regulating T cell responses: mechanisms and outcome. Trends Immunol. 2015 Jan;36(1):49-58.

12. Crome SQ, Lang PA, Lang KS, Ohashi PS. Natural killer cells regulate diverse T cell responses. Trends Immunol. 2013 Jul;34(7):342-9. 

11. Lang PA, Recher M, Häussinger D, Lang KS. Genes determining the course of virus persistence in the liver: lessons from murine infection with lymphocytic choriomeningitis virus. Cell Physiol Biochem. 2010;26(3):263-72.

10. Lang F, Gulbins E, Lang PA, Zappulla D, Föller M. Ceramide in suicidal death of erythrocytes. Cell Physiol Biochem. 2010;26(1):21-8.

9. Lang KS, Burow A, Kurrer M, Lang PA, Recher M. The role of the innate immune response in autoimmune disease. J Autoimmun. 2007 Dec;29(4):206-12.

8. Lang F, Lang KS, Lang PA, Huber SM, Wieder T. Osmotic shock-induced suicidal death of erythrocytes. Acta Physiol (Oxf). 2006 May-Jun;187(1-2):191-8.

7. Lang F, Lang KS, Lang PA, Huber SM, Wieder T. Mechanisms and significance of eryptosis. Antioxid Redox Signal. 2006 Jul-Aug;8(7-8):1183-92.

6. Lang KS, Lang PA, Bauer C, Duranton C, Wieder T, Huber SM, Lang F. Mechanisms of suicidal erythrocyte death. Cell Physiol Biochem. 2005;15(5):195-202. 

5. Lang F, Föller M, Lang KS, Lang PA, Ritter M, Gulbins E, Vereninov A, Huber SM. Ion channels in cell proliferation and apoptotic cell death. J Membr Biol. 2005 Jun;205(3):147-57. 

4. Lang F, Gulbins E, Szabo I, Lepple-Wienhues A, Huber SM, Duranton C, Lang KS, Lang PA, Wieder T. Cell volume and the regulation of apoptotic cell death. J Mol Recognit. 2004 Sep-Oct;17(5):473-80.

3. Lang F, Birka C, Myssina S, Lang KS, Lang PA, Tanneur V, Duranton C, Wieder T, Huber SM. Erythrocyte ion channels in regulation of apoptosis. Adv Exp Med Biol. 2004;559:211-7.

2. Lang F, Lang PA, Lang KS, Brand V, Tanneur V, Duranton C, Wieder T, Huber SM. Channel-induced apoptosis of infected host cells-the case of malaria. Pflugers Arch. 2004 Jun;448(3):319-24. 

1. Lang F, Lang KS, Wieder T, Myssina S, Birka C, Lang PA, Kaiser S, Kempe D, Duranton C, Huber SM. Cation channels, cell volume and the death of an erythrocyte. Pflugers Arch. 2003 Nov;447(2):121-5. 

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