Publikationen 2005 und älter

tegger, L., K.P. Schäfers, U. Flögel, L. Livieratos, S. Hermann, C. Jacoby, P. Keul, E.M. Conway, O. Schober, J. Schrader, B. Levkau and M. Schäfers: Monitoring left ventricular dilation in mice with PET. J. Nucl. Med. 46(9):1516-1521,  2005

Limbourg, F.P., S. Ringes-Lichtenberg, A. Schaefer, C. Jacoby, Y. Mehraein, M.D. Jäger, A. Limbourg, M. Fuchs, G. Klein, M. Ballmaier, H.J. Schlitt, J. Schrader, D. Hilfiker-Kleiner and H. Drexler: Haematopoietic stem cells improve cardiac function after infarction without permanent cardiac engraftment.Eur.J.Heart Fail. 7:722-729, 2005

Gödecke, S., T. Stumpe, H. Schiller, H.J. Schnittler and J. Schrader: Do rat cardiac myocytes release ATP on contraction? Am.J.Physiol. Cell Physiol. 289(3):C609-C616, 2005

Frank, K.F., B. Bölck, Z. Ding, D. Krause, N. Hattebuhr, A. Malik, K. Brixius, R.J. Hajjar, J. Schrader and R.H.G. Schwinger: Overexpression of sorcin enhances cardiac contractility in vivo and in vitro. J. Molec. Cell. Cardiol. 38:607-615, 2005

Martin, M., J. Meyer-Kirchrath, G. Kaber, C. Jacoby, U. Flögel, J. Schrader, U. Rüther,  K. Schrör and T. Hohlfeld: Cardiospecific overexpression of the prostaglandin EP3 receptor attenuates ischemia-induced myocardial injury. Circulation 112(3):400-406, 2005

Merx, M.W., E.A. Liehn, J. Graf, A. van der Sandt, M. Schaltenbrand, J. Schrader, P. Hanrath and C. Weber: Statin treatment after onset of sepsis in a murine model improves survival. Circulation  112:117-124, 2005

Merx, W. M., A. Gödecke, U. Flögel and J. Schrader: Oxygen supply and nitric oxide scavenging by myoglobin contribute to exercise endurance and cardiac function. FASEB J. (online 10.1096/fj.04-2886fje) 19(8):1015-1017, 2005

Flögel, U., T. Laussmann, A. Gödecke, N. Abanador, M. Schäfers, C.D. Fingas, S. Metzger, B. Levkau, C. Jacoby and J. Schrader: Lack of myoglobin causes a switch in cardiac substrate selection. Circ.Res. 96(8):e68-e75, 2005

Özüyaman, B., A. Gödecke, S. Küsters, E. Kirchhoff, R.E. Scharf and J. Schrader: Endothelial nitric oxide synthase plays a minor role in inhibition of arterial thrombus formation. Thromb. Haemost. 93:1161-1167, 2005

Koszalka, P., B. Özüyaman, Y. Huo, A. Zernecke, U. Flögel, N. Braun, A. Buchheiser, U.K.M. Decking, M.L. Smith, J. Sévigny, A. Gear, A.-A. Weber, A. Molojavyi, Z. Ding, C. Weber, K. Ley, H. Zimmermann, A. Gödecke and J. Schrader: Targeted disruption of cd73/ecto-5´-nucleotidase alters thrombo-regulation and augments vascular inflammatory response. Circ.Res. 95(8):814-821, 2004

Sasse, A., Z. Ding, M. Wallich, A. Gödecke and J. Schrader: Vascular transfer of adenovirus is augmented by nitric oxide in the rat heart. Am.J.Physiol. Heart Circ.Physiol: 287:H1362-H1368, 2004

Flögel, U., A. Gödecke, L.O. Klotz, and J. Schrader: Role of myoglobin in the antioxidant defense of the heart. FASEB J. 18(10):1156-1158, 2004

Merx, M.W., E.A. Liehn, U. Janssens, R. Lütticken, J. Schrader, P. Hanrath and C. Weber: HMG-CoA-reductase inhibitor Simvastatin profoundly improves survival in murine model of sepsis. Circulation 109:2560-2565, 2004

Warskulat, U., U. Flögel, C. Jacoby, H. Hartwig, M. Thewissen, M. Merx, A. Molojavyi, B. Heller-Stilb, J. Schrader and D. Häussinger: Taurine transporter knockout depletes muscle taurine levels and results in severe skeletal muscle impairment but leaves cardiac function uncompromised. FASEB J. 18(3):577-579, 2004

Wallerath,T., A. Gödecke, A. Molojavyi, H. Li, J. Schrader and U. Förstermann: Dexamethasone lacks effect on blood pressure in mice with a disrupted endothelial NO synthase gene. Nitric Oxide 10(1):36-41, 2004

Schlieper, G., J.H. Kim, A. Molojavyi, C. Jacoby, T. Laussmann, U. Flögel, A. Gödecke and J. Schrader: Adaptation of the myoglobin knockout mouse to hypoxic stress. Am.J.Physiol.  Regul.Integr.Comp.Physiol. 286(4):R786-R792, 2004

Goettsch, S., and J. Schrader: Erfolge, aber viele ungelöste Fragen - Kardiale Stammzelltherapie, ein kritisches Wort (II). CardioVasc 3:22-24, 2004

Gödecke, A., and J. Schrader: The Janus Faces of NO? Letter to the Editor. Circ.Res.94:e55, Apr 2004

Randriamboavonjy, V., J. Schrader, R. Busse and I. Fleming: Insulin induces the release of vasodilator compounds from platelets by a nitric oxide/G kinase/VAMP-3-dependent pathway: a novel mechanism of insulin-induced vasodilation. J.Exp.Med. 199:347-356, 2004

Liimatta, E.V., A. Gödecke, J. Schrader and I.E. Hassinen: Regulation of cellular respiration in myoglobin-deficient mouse heart. Molec.Cell.Biochem. 256/257:201-208, 2004

Ding, Z., C. Fach, A. Sasse, A. Gödecke and J. Schrader: A minimally invasive approach for efficient gene delivery to rodent hearts. Gene Therapy 11(3):260-265, 2004

Sasse, A., M. Wallich, Z. Ding, A. Gödecke and J. Schrader: Coxsackie-and-adenovirus receptor mRNA expression in human heart failure. The Journal of Gene Medicine 5:876-882, 2003

Kleinbongard, P., A. Dejam, T. Lauer, T. Rassaf, A. Schindler, O. Picker, T. Scheeren, A. Gödecke, J. Schrader, R. Schulz, G. Heusch, G. Schaub, N. Bryan, M. Feelisch and M. Kelm: Plasma nitrite reflects constitutive nitric oxide synthase activity in mammals. Free Radical Biology & Medicine 7:790-796, 2003

Wunderlich, C., U. Flögel, A. Gödecke, J. Heger and J. Schrader: Acute inhibition of myoglobin impairs contractility and energy state of iNOS-overexpressing hearts. Circ.Res. 92(12):1352-1358, 2003

Gödecke, A., A. Molojavyi, J. Heger, U. Flögel, Z. Ding, C. Jacoby and J. Schrader: Myoglobin protects the heart from inducible nitric-oxide synthase (iNOS)-mediated nitrosative stress. J.Biol.Chem. 278(24):21761-21766, 2003

Muhs, A., B. Heublein, J. Schletter, A. Herrmann, M. Rüdiger, M. Sturm, A. Grust, J. Malms, J. Schrader and H. von der Leyen: Preclinical evaluation of inducible nitric oxide synthase – Lipoplex gene therapy for inhibition of stent-induced vascular neointimal lesion formation.Human Gene Therapy 14:375-383, 2003

Doreulee, N., O.A. Sergeeva, Y. Yanovsky, A.N. Chepkova, O. Selbach, A. Gödecke, J. Schrader and H.L. Haas: Cortico-striatal synaptic plasticity in endothelial nitric oxide synthase deficient mice. Brain Research 964:159-163, 2003

Kojic, Z.Z., U. Flögel, J. Schrader and U.K.M. Decking: Endothelial NO formation does not control myocardial O2 consumption in mouse heart. Am. J.Physiol.Heart Circ.Physiol. 285(1):H392-H397, 2003

Schrader J.: Bidlgebung des Herzens und der Gefäße: Die Maus als Modellsystem. Jahrbuch der Heinrich-Heine-Universität; ISBN 3-98085 14-2-7; 2003

Wegener, J.W., A. Gödecke, J. Schrader and H. Nawrath: Effects of nitric oxide donors on cardiac contractility in wild-type and myoglobin-deficient mice. Br.J.Pharmacol. 136:415-420, 2002

Ding, Z., A. Gödecke and J. Schrader: Contribution of cytochrome P450 metabolites in bradykinin-induced vasodilation in endothelial NOsynthase deficient mouse hearts.Br.J.Pharmacol. 135:631-638, 2002

Laussmann, T., R.A. Janosi, C.D. Fingas, G.R. Schlieper, W. Schlack, J. Schrader and U.K.M. Decking: Myocardial proteome analysis reveals reduced NOS inhibition and enhanced glycolytic capacity in areas of low local blood flow. FASEB J. 16:628-630, 2002 (full text here )

Gödecke, A., M. Ziegler, Z. Ding and J. Schrader: Endothelial dysfunction of coronary resistance vessels in apoE-/-mice involves NO but not prostacyclin-dependent mechanisms. Cardiovasc.Res. 53:253-262, 2002

Heger J, Gödecke A, Flögel U, Merx MW, Molojavyi A, Kühn-Velten WN, Schrader J, : Cardiac-specific overexpression of inducible nitric oxide synthase does not result in severe cardiac dysfunction. Circ.Res. 90(1):93-99, 2002 Heger, J., A. Gödecke, U. Flögel, M.W. Merx, A. Molojavyi, W.N. Kühn-Velten

Decking, U.K.M., and J. Schrader: Räumliche Heterogenität von myokardialer Durchblutung und Stoffwechsel. Z. Kardiol. 90:970-977, 2001

Dere, E., C. Frisch, M.A. de Souza Silva, A. Gödecke, J. Schrader and J.P. Huston: Unaltered radial maze performance and brain acetylcholine of the endothelial nitric oxide synthase knockout mouse. Neuroscience 107(4): 561-570, 2001

Gödecke, A., T. Heinicke, A. Kamkin, I. Kiseleva, R.H. Strasser, U.K.M. Decking, T. Stumpe, G. Isenberg and J. Schrader: Inotropic response to -adrenergic receptor stimulation and anti-adrenergic effect of ACh in endothelial NO synthase-deficient mouse hearts. J.Physiol. 532.1:195-204, 2001

Ishibashi, T., A. Gödecke and J. Schrader: Protein Kinase A- and C-dependent modulation of murine inducible nitric oxide synthase. Tohoku J.Exp. Med. 194:75-90, 2001

Doreulee,N., R.E. Brown, Y. Yanovsky, A. Gödecke, J. Schrader and H.L. Haas: Defective hippocampal mossy fiber long-term potentiation in endothelial nitric oxide synthase knockout mice. Synapse 41:191-194, 2001

Decking, U.K.M., J.P. Williams, R. Dahmann, T, Stumpe, M. Kelm and J. Schrader: The nitric oxide-induced reduction in cardiac energy supply is not due to inhibition of creatine kinase. Cardiovasc.Res. 51:313-321, 2001

Decking, U.K.M., C. Alves, T. Wallimann, M. Wyss and J. Schrader: Functional aspects of creatine kinase isoenzymes in endothelial cells. Am.J.Physiol. Cell.Physiol. 281:C320-C328, 2001

Flögel, U., M.W. Merx , A. Gödecke, U.K.M. Decking, and J. Schrader: Myoglobin: a scavenger of bioactive NO. Proc.Natl.Acad.Sci.USA 98(2): 735-740, 2001

Merx, M.W., U. Flögel, T. Stumpe, A. Gödecke, U.K.M. Decking and J.Schrader: Myoglobin facilitates oxygen diffusion. FASEB J. 15: 1077-1079, 2001 

Stumpe, T., U.K.M. Decking and J. Schrader: Nitric oxide reduces energy supply by direct action on the respiratory chain in isolated cardiomyocytes. Am.J.Physiol. Heart Circ.Physiol. 280: H2350-H2356, 2001

Stumpe, T., and J. Schrader: Short-term hibernation in adult cardiomyocytes is PO2-dependent and Ca2+-mediated. Am.J.Physiol. Heart Circ.Physiol. 280(1): H42-H50, 2001

Decking, U.K.M., S. Skwirba, M.F. Zimmermann, B. Preckel, V. Thämer, A. Deussen and J. Schrader: Spatial heterogeneity of energy turnover in the heart. Pflügers Arch.-Eur.J.Physiol. 441:663-673, 2001

Decking, U.K.M., L. Vogler, M. Hartmann, and J. Schrader: Multinuclear MR-spectroscopy on ion-homeostasis and energetics during ischemia and reperfusion. MAGMA 11:3-4, 2000

Gödecke, A., and J. Schrader: Adaptive mechanisms of the cardiovascular system in transgenec mice – lessons from eNOS and myoglobin knockout mice. Basic Res.Cardiol. 95:492-498, 2000

Frisch, C., E. Dere, M.A. De Souza Silva, A. Gödecke, J. Schrader and J.P. Huston: Superior water maze performance and increase in fear-related behaviour in the endothelial nitric oxide synthase-deficient mouse together with monoamine changes in cerebellum and ventral striatum. J.Neuroscience 20(17):6694-6700, 2000

Wagner, C., A. Gödecke, M. Ford, J. Schnermann, J. Schrader and A. Kurtz: Regulation of renin gene expression in kidneys of eNOS- and nNOS-deficient mice. Pflügers Arch.– Eur.J.Physiol. 439:567-572, 2000

Todorov, V., B. Gess, A. Gödecke, C. Wagner, J. Schrader and A. Kurtz: Endogenous nitric oxide attenuates erythropoietin gene expression in vivo. Pflügers Arch.-Eur.J.Physiol. 439: 445-448, 2000

Herrmann, A., M. Pieper and J. Schrader: Selection of cell specific peptides in a rat carotid injury model using a random peptide-presenting bacterial library. BBA 1472: 529-536, 1999

Gödecke, A., U. Flögel, K. Zanger, Z. Ding, J. Hirchenhain, U.K.M. Decking and J. Schrader: Disruption of myoglobin in mice induces multiple compensatory mechanisms. Proc. Natl. Acad. Sci. USA 96(18): 10495-10500, 1999

Staus, H.M., A. Gödecke, R. Mrowka, J. Schrader and P.B. Persson: Enhanced blood pressure variability in eNOS knock-out mice. Hypertension 33: 1359-1363, 1999

Culic, O., U.K.M. Decking and J. Schrader: Metabolic adaption of endothelial cells to substrat deprivation. Am. J. Physiol. 276 (Cell.Physiol. 45): C1061-C1068, 1999

Flögel, U., U.K.M. Decking, A. Gödecke and J. Schrader: Contribution of NO to ischemia-reperfusion injury in the saline-perfused heart: A study in endothelial NO synthase knockout mice. J. Mol. Cell. Cardiol. 31(4):827-836, 1999

Culic, O., U.K.M. Decking, E. Bergschneider and J. Schrader: Purinogen is not an endogenous substrate used  in endothelial cells during substrate deprivation. Biochem. J. 338:523-527, 1999

Wilson, R.I., A. Gödecke, R.E. Brown, J. Schrader and H.L. Haas: Mice deficient in endothelial nitric oxide synthase exhibit a selective defecit in hippocampal long-term potentiation. Neuroscience 90(No4):1157-1165, 1999

Haul, S, A. Gödecke, J. Schrader, H.L. Haas and H.J. Luhmann: Impairment of neocortical long-term potentiation in mice deficient of endothelial nitric oxide synthase. J. Neurophysiol. 81:494-497, 1999

Decking, U.K.M., and J. Schrader: Role of adenosine kinase and AMP deaminase in the regulation of cardiac purine release. In: Proceedings 6th International Symposium on Purines and Pyrimidines. Drug Development Res. 45:295-303, 1998

Schrader, J., and U. Decking: Sites and mechanism of adenosine formation in the cardiovascular system. In: Proceedings 6th International Symposium on Purines and Pyrimidines. Drug Development Res. 45:288-294, 1998

Herrmann, A., G. Müller, A. Gödecke and J. Schrader: Recombination of nonreplicative RNA precursors of Sindbis virus in infected cells overexpressing murine inducible nitric oxide synthase. Biochem. Biophys. Res. Comm.  253: 524-531, 1998

Decking, U.K.M., J. Schrader: Spatial heterogeneity of myocardial perfusion and metabolism.  Basic Res Cardiol 93: 439-445, 1998

Schrader, J., U.K.M. Decking and T. Stumpe: Recent advances in cardiac adenosine metabolism. In: G. Burnstock, J.G. Dobson, B.T. Liang, J. Linden (eds.) Cardiovascular Biology of Purines. Kluwer Academic Publ. Boston/USA, pp 312-325, 1998

Hartmann, M., U.K.M. Decking and J. Schrader: Cardioprotective actions of KC 12291. II. Delaying Na+ overload in ischemia improves cardiac function and energy status in reperfusion. Naunyn-Schmiedeberg’s Arch. Pharmacol. 358: 554-560, 1998

Decking. U.K.M., M. Hartmann, H. Rose, R. Brückner, J. Meil and J. Schrader: Cardioprotective actions of KC 12291. I. Inhibition of voltage-gated Na+-channels in ischemia delays myocardial Na+ overload. Naunyn-Schmiedeberg’s Arch. Pharmacol. 358: 547-553, 1998

Decking, U.K.M., S. Skwirba, M.F. Zimmermann, B. Preckel, R. Loncar, V. Thämer, A. Deussen and J. Schrader: Does local coronary flow control metabolic flux rates? A 13C-NMR study. MAGMA 6: 133-134, 1998

Karczewski, P., T. Hendrischke, W.-P. Wolf, I. Morano, S. Bartel and J. Schrader: Phosphorylation of phospholamban correlates with relaxation of coronary artery induced by nitric oxide, adenosine, and prostacyclin in the pig. J.Cell.Biochem. 70:49-59, 1998

Schrader, J., A. Deussen and U.K.M. Decking: Adenosine metabolism and transport in the mammalian heart. In: Effects of extracellular adenosine and ATP on cardiomyocytes. Eds. Pelleg, A., and L. Belardinelli. R. G. Landes Comp, Austin/TX, USA, pp 39-85, 1998

Gödecke, A., U.K.M. Decking, Z. Ding, J. Hirchenhain, H.-J. Bidmon, S. Gödecke and J. Schrader: Coronary hemodynamics in endothelial NO synthase knockout mice. Circ.Res. 82:186-194, 1998

Gruwel, M.L.H., O. Culic, A. Muhs, J.P. Williams and J. Schrader: Regulation of endothelial Na+-K+-ATPase activity by cAMP. Biochem.Biophys.Res.Comm. 242: 93-97, 1998

Kelm, M., S. Schäfer, R. Dahmann, B. Dolu, S. Perings, U. Decking, J. Schrader and B.E. Strauer: Nitric oxide induced contractile dysfuntion is related to a reduction in myocardial energy generation. Cardiovasc.Res. 36/Vol.2:185-194, 1997

Gruwel, M.L.H., O. Culic, J. Schrader: A 133Cs nuclear magnetic resonance study of endothelial Na+-K+-ATPase activity: can actin regulate its activity? Biophysical J. 72: 2775-2782, 1997

Culic, O., M.L.H. Gruwel, J. Schrader: Energy turnover of vascular endothelial cells. Am.J.Physiol. 273 (Heart Circ.Physiol. 42): C205-C213, 1997

Decking, U.K.M., G. Schlieper, K. Kroll and J. Schrader: Hypoxia-induced inhibition of adenosine kinase potentiates cardiac adenosine release. Circ.Res. 81: 154-164, 1997

Stumpe, T., J. Schrader: Phosphorylation potential, adenosine formation, and critical PO2  in stimulated rat cardiomyocytes. Am.J.Physiol. 273 (Heart Circ. Physiol. 42): H756-H766, 1997

Gruwel, M.L.H., O. Culic, A. Muhs, J. Williams, J. Schrader: Short term regulation of endothelial Na+-K+-ATPase by nitric oxide: a Cs+ magnetic resonance study. Int.Soc.Magn.Reson., Vancouver. Proceed.: 544, 1997

Wilson, R.I., J. Yanovsky, A. Gödecke, D.R. Stevens, J. Schrader, H. Haas: Endothelial nitric oxide synthase and LTP. Nature, Vol 386/issue 6623: 338, 1997

Decking, U.K.M., S. Arens, G. Schlieper, K. Schulze, J. Schrader: Dissociation between adenosine release, MVo2, and energy status in working guinea pig hearts. Am.J. Physiol. 272 (Heart Circ. Physiol. 41): H371-H381, 1997

Schrader, J., U. Decking: Regulation der Koronardurchblutung durch Adenosin. Z. Kardiol. 85: Suppl 6: 153-159, 1996

Gruwel, M.L.H., O. Culic, J. Schrader: Regulation of Na+-K+-ATPase activity in porcine vascular endothelial cells as studied by 133Cs NMR. Int.Soc.Magn.Reson., New York. Proceed.: 273, 1996

Gruwel, M.L.H., O. Culic, J. Schrader: Energy turnover in endothelial cells: a 31P NMR and microcalorimetry study. Int.Soc.Magn.Reson., New York. Proceed.: 270, 1996

Deussen, A., C.W. Flesche, T. Lauer, M. Sonntag, J. Schrader: Spatial heterogeneity of blood flow in the dog heart. II: Temporal stability in response to adrenergic stimulationPfluegers Arch.-Eur.J.Physiol. 432:451-461, 1996

Sonntag, M., A. Deussen, J. Schultz, R. Loncar, W. Hort, J. Schrader: Spatial heterogeneity of blood flow in the dog heart. I: Glucose uptake, free adenosine and oxidative/glycolytic activity. Pfluegers Arch.-Eur.J.Physiol.432:439-450, 1996

Huston, J.P., H.L. Haas, M. Pfister, F. Boix, U. Decking, J. Schrader, R.K.W. Schwarting:  Extracellular adenosine levels in  neostriatum  and  hippocampus during rest and activity periods of rats. Neuroscience 73 (No 1): 90-107, 1996

Gödecke, S., U.K.M. Decking, A. Gödecke, J. Schrader: Cloning of the rat P2u receptor and its potential role in coronary vasodilation.  Am.J.Physiol. 270 (Cell Physiol. 39): C570-C577, 1996

Schrader, J., P. Karczewski, U. Decking: Mechanisms by which nitric oxide controls vascular smooth muscle tone and myocardial contractile force. In: E.K. Weir, S. Archer and J.T. Reeves (eds.)  Nitric  Oxide and Radicals in the Pulmonary Vasculature. Futura Publishing Comp., Inc. USA, pp 415-426, 1995

Schrader, J., U. Decking, T. Stumpe: Cardiac energetics and adenosine formation. In: Adenosine and adenine nucleotides from molecular biology to integrative physiology. Eds. Belardinelli, L., Pelleg, A. Kluwer Acedemic Publishers, Boston/USA. pp 169-177, 1995

Gruwel, M.L.H., O. Culic, J. Schrader: 133Cs NMR studies of K+ fluxes in porcine vascular endothelial cells. Int.Soc.Magn.Reson., Nice. Proceed.: 1739, 1995

Hartmann, M., T. Stumpe, J. Schrader: 1-Adrenergic stimulation inhibits the isoproterenol-induced effects on myocardial contractility and protein phosphorylation. Europ.J.Pharmacol. 54479, 1995

Flesche, W.C., M.L.H. Gruwel, A. Deussen, J. Schrader: Observation of reorientationally hindered water in biological tissue using triple quantum filtered 17O-NMR. Biochim.Biophys. Acta 1244: 253-258, 1995

Decking, U.K.M., T. Reffelmann, J. Schrader, H. Kammermeier: Hypoxia-induced activation of KATP-channels limits energy depletion in the guinea pig heart. Am.J.Physiol. 269 (Heart Circ. Physiol. 38):H734-H742, 1995

Decking, U.K.M., C. Flesche, A. Gödecke, J. Schrader: Endotoxin-induced contractile dysfunction in the guinea pig heart is not mediated by nitric oxide. Am.J.Physiol. 268 (Heart Circ. Physiol. 37):H2460-H2465, 1995

Gruwel, M.L.H., Ch. Alves, J. Schrader: Na+-K+-ATPase in endothelial cell energetics: a 23Na nuclear magnetic resonance and calorimetry study. Am.J.Physiol. 268 (Heart Circ. Physiol. 37):H351-H358, 1995

Gruwel, M.L.H., C. Alves, J. Schrader: 23Na Nuclear Magnetic Resonance study of intracellular sodium in vascular endothelial cells. BBA, 1224:228-236, 1994

Pak, M.A., H.L. Haas, U.K.M. Decking, J. Schrader: Inhibition of adenosine kinase increases endogenous adenosine and depresses neuronal activity in hippocampal slices. Neuropharmacol., Vol.33, 9:1049-1053, 1994

Schrader, J.: Das Herz. In: Lehrbuch der Physiologie (Hrsg. Klinke/Silbernagel), Georg Thieme Verlag Stuttgart; S.99-134, 1994

Schrader, J., M. Gruwel, U. Decking, Ch. Alves: Wozu benötigen Endothelzellen Adenosintriphosphat? Arzneim.-Forsch./Drug Res. 44(I),3a:436-438, 1994

Decking, U.K.M., C. Alves, R. Spahr, J. Schrader: 2-fluor-adenosine uptake by erythrocytes and endothelial cells studied by 19F NMR. Am.J.Physiol. 266:H1596-H1603, 1994

Gödecke, A., J. Schrader: Transgene Tiere: Herausforderung an die integrative Physiologie. Physiologie - Forschung/Lehre/ Öffentlichkeitsarbeit 1:16-22, 1993

Kroll, K., U.K.M. Decking, K. Dreikorn, J. Schrader: Rapid turnover of the AMP- adenosine metabolic cycle in the guinea pig heart. Circ.Res. 73:846-856, 1993

Lloyd, H.G.F., J. Schrader: Adenosine metabolism in the guinea pig heart: the role of cytosolic S-adenosyl-L-homocysteine hydrolase, 5'-nucleotidase and adenosine kinase. European Heart Journal 14(Suppl.I): 27-33, 1993

Hartmann, M., J. Schrader: Isoproterenol antagonistic effect of 2', 5'-dideoxyadenosine in the isolated perfused guinea pig heart. J.Mol.Cell.Cardiol. 25:331-338, 1993

Kroll, K., J. Schrader: Myocardial adenosine stimulates release of cyclic adenosine monophosphate from capillary endothelial cells in guinea pig heart. Pflügers Arch. 423:330-337, 1993

Schrader, J.: Physiologie und Pharmakologie der Nitrate. Münchner Medizinische Wochenschrift 135, Suppl.1: 15-19, 1993

Deussen, A., M. Henrich, K. Hamacher, M. Borst, H. Herzog, H. Coenen, G. Stöcklin, L.E. Feinendegen, J. Schrader: Noninvasive assessment of regional cardiac adenosine using positron emission tomography. J.Nuclear Medicine. 33 (12): 2138-2144, 1993

Deussen, A., B. Bading, M. Kelm, J. Schrader: Formation and salvage of adenosine by macrovascular endothelial cells. Am.J.Physiol. 264 (Heart Circ Physiol 33): H692-H700, 1993

Schrader, J.: Regulation of coronary blood flow by adenosine. Pharm Pharmacol Lett 2:5-7, 1992

Karczewski, P., M. Kelm., M. Hartmann, J. Schrader: Role of phospholamban in NO/EDRF-induced relaxation in rat aorta. Life Sciences, 51:1205-1210, 1992

Hartmann, M., J. Schrader: Exo-protein kinase release from intact cultured aortic endothelial cells. Biochim.Biophys. Acta, 1136:189-195, 1992

226:225-231, 1992 Hartmann, M., J. Schrader: Protein kinase C phosphorylates a 15 kDa protein but not phospholamban in intact rat cardiac myocytes. Europ.J.Pharm., MOL

Borst, M.M., A. Deussen, J. Schrader: S-adenosylhomocysteine hydrolase activity in human myocardium. Cardiovasc.Res. Vol. XXVI, No 2:143-147, 1992

Unitt, J.F., J. Schrader, F. Brunotte, G.K. Radda, A.-M. Seymour: Determination of free creatine and phosphocreatine concentrations in the isolated perfused rat heart by 1H- und 31P-NMR. Biochim.Biophys.Acta, 1133:115-120, 1992

Sonntag, M., A. Deussen, J. Schrader: Role of nitric oxide in local blood flow control in the anaesthetized dog. Pflügers Arch. 420:194-199, 1992

Kostic, M., J. Schrader: Role of nitric oxide in reactive hyperemia of the guinea pig heart.Circ.Res. 70:208-212, 1992

Kelm, M., M. Feelisch, A. Deussen, B.E. Strauer, J. Schrader: Release of endothelium derived nitric oxide in relation to pressure and flow. Cardiovasc.Res. Vol. XXV, No 10:831-836, 1991

Kelm, M., M. Feelisch, A. Deussen, J. Schrader, B.E. Strauer: The role of nitric oxide in the control of coronary vascular tone in relation to partial oxygen pressure, perfusion pressure, and flow. J.Cardiovasc.Pharmacol. 17, Suppl.3:95-99, 1991

Deussen, A., J. Schrader: Cardiac adenosine production is linked to myocardial pO2. J.Mol.Cell.Cardiol. 23:495-504, 1991

Borst, M., J. Schrader: Adenine nucleotide release from isolated perfused guinea pig hearts and extracellular formation of adenosine. Circ.Res. 68:797-806, 1991

Smolenski, R.T., J. Schrader, H. de Groot, A. Deussen: Oxygen partial pressure and free intracellular adenosine of isolated cardiomyocytes. Am.J.Physiol. 260/4:C708-C714, 1991

Schrader, J.: Formation and metabolism of adenosine and adenine nucleotides in cardiac tissue. (Review). In: J.W. Phillis (ed.) Adenosine and adenine nucleotides as regulators of cellular function. CRC-press, pp 55-69, 1991

Deussen, A., Ch. Walter, M. Borst, J. Schrader: Transmural gradient of adenosine in canine heart during functional hyperemia. Am.J.Physiol. 260:H671-H680, 1991

Schrader, J., M. Borst, M. Kelm, T. Smolenski, A. Deussen: Intra- and extracellular formation of adenosine by cardiac tissue. In: S. Imai and M. Nakazawa (eds.) Role of adenosine and adenine nucleotides in the biological system. Elsevier Science Publishers, Amsterdam, pp 261-271, 1991

Hartmann, M., M. Kelm, J. Schrader: Protein phosphorylation in intact coronary endothelial cells by bradykinin. Life Sciences 48:1619-1629, 1991

Deussen, A., J. Schrader: Assessment of local tissue adenosine by measurements of S-adenosylhomocysteine (SAH). In: S. Imai and M. Nakazawa (eds.) Role of adenosine and adenine nucleotides in the biological system. Elsevier Science Publishers, Amsterdam, pp 557-568, 1991

Schrader, J., A. Deussen, R.T. Smolenski: Adenosine is a sensitive oxygen sensor in the heart. Experientia 46:1172-1175, 1990

Schrader, J.:  Adenosine  -  A homeostatic metabolite in cardiac energy meta- bolism.Circ. 81:389-391, 1990

Moncada, E.A. Higgs (eds.) Nitric oxide from L-arginine: a bioregulatory system. Elsevier Science Publishers, pp 47-53, 1990

Kelm, M., J. Schrader: Control of coronary vascular tone by nitric oxide. Circ.Res. 66:1561-1575, 1990

Kelm M., Schader J.: Comparison of nitric oxide formation in cultured endothelial cells and isolated guinea-pig hearts. Elsevier Science Pub. Nitric oxide from L-arginine: a bioregulatory system. 1990

Kelm, M., M. Feelisch, J. Schrader: Release of the free nitric oxide radical (NO) and EDRF from endothelial cells. Z.Kardiol. 78, Suppl. 6:70-74, 1989

Endothel der isoliert perfundierten Rattenaorta. Z.Kardiol. 78, Suppl. 6:50-53, 1989 Schrader, J., K. Kroll, M. Kelm, K.F. Bürrig: Transport von Adenosin über das

Möser, G.H., J. Schrader, A. Deussen: Turnover of adenosine in plasma of human and dog blood. Am.J.Physiol. 256 (Cell Physiol. 25):C799-806, 1989

Kroll, K., M. Kelm, K.F. Bürrig, J. Schrader: Transendothelial transport and metabolism of adenosine and inosine in the intact rat aorta. Circ.Res. 64:1147-1157, 1989

Contribution of S-adenosylhomocysteine to cardiac adenosine formation. J.Mol.Cell.Cardiol. 21:773-782, 1989 Deussen, A., H.G.E. Lloyd, J. Schrader:

Wiesner, R.J., A. Deussen, M. Borst, J. Schrader, M.K. Grieshaber: Glutamate degradation in the ischemic dog heart: Contribution to anaerobic energy production.J.Cell.Mol.Cardiol. 21:49-59, 1989

Jug.Physiol.Pharm.Acta, 24 Suppl. 6:71-72, 1988 Schrader, J.: Control of coronary vascular tone by endothelium-derived Adenosine

Lloyd, H.G.E., A. Deussen, H. Wuppermann, J. Schrader: The transmethylation pathway as a source for adenosine in the isolated guinea-pig heart. Biochem.J. 252:489-494, 1988

Kelm, M., J. Schrader: Nitric oxide release from isolated guinea pig heart. Eur.J.Pharmacol. 155:317-321, 1988

Schrader J., Deussen A.: Free Cytosolic Adenosine Sensitively Signals Myocardial Hypoxia. Oxygen Sensing Tissues, Springer Verlag 1988

Kelm, M., M. Feelisch, R. Spahr, H.M. Piper, E. Noack, J. Schrader: Quantitative and kinetic characterization of nitric oxide and EDRF released from cultured endothelial cells.Biochem.Biophys.Res.Comm. 154:236-244, 1988

Deussen, A., M. Borst, K. Kroll, J. Schrader: Formation of S-adenosylhomocysteine in the heart II: a sensitive index for regional myocardial underperfusion. Circ.Res. 63:250-261, 1988

Deussen, A., M. Borst, J. Schrader: Formation of S-adenosyl-homocysteine in the heart. I: an index of free intracellular adenosine. Circ.Res. 63:240-249, 1988

Llyod H. G. E., Schrader J.: The importance of The Transmethylation Pathway for Adenosine Metabolism in the Heart;  Physiological Insititute I, University of Duesseldorf

Henrich, M., H.M. Piper, J. Schrader: Evidence for adenylate cyclase-coupled A1-adenosine receptors on ventricular cardiomyocytes from adult rat and dog heart. Life Sciences, 41:2381-2388, 1987

Schrader, J., K. Kroll, M. Henrich, H.M. Piper: Coronary and myocardial adenosine receptors. Biomed.Biochem.Acta 46, 8/9:421-426, 1987

Kroll, K., H.M. Piper, J. Schrader, M. Henrich: Release of adenosine and cyclic AMP from coronary endothelium in isolated guinea pig hearts: Relation to coronary flow. Circ.Res. 60:659-665, 1987

Bardenheuer, H., J. Schrader: Supply-to-demand ratio for oxygen determines formation of adenosine by the heart. Am.J.Physiol. 250:H 173-180, 1986

Deussen, A., G. Möser, J. Schrader: Contribution of coronary endothelial cells to cardiac adenosine production. Pflügers Arch. 406:608-614, 1986

Schrader, J., H. Bardenheuer, J. Ontyd: Relationships between myocardial metabolism and coronary blood flow regulation. Cardiologica, p. 915-919, 1985

Schrader J., Deussen A.: Adenosine-xanthine interactions in the heart, Excerpta Medica, Current Clinical Practice Series No.19, Symposium Copenhagen, 1985

Schrader, J.: Mechanisms of ischemic injury in the heart. Basic Res.Cardiol. 80:135-139 (1985)

Schrader, J.: Mechanismen der koronaren Durchblutungsregulation (review). Z.Kardiol. 73:41-46, 1984

Schrader , J., Bardenheuer H.: Ist Adenosin ein empfindlicher Hypoxie-Parameter am Herzen? Erwin Riesch-Symposium, Westerland Akademie de Wissenschaften, Mainz, Franz Steiner Verlag Wiesbaden, 1983

Dobson, Jr., I.G., J. Schrader: Role of extracellular and intracellular adenosine in the attenuation of catecholamine evoked responses in guinea pig heart. J.Mol.Cell.Cardiol. 16:813-822, 1984

Ontyd, J., J. Schrader: Measurements of adenosine, inosine and hypoxanthine in human plasma. J.Chromatogr. 307:404-409, 1984

Bardenheuer, H., J. Schrader: Relationship between myocardial oxygen consumption, coronary flow and adenosine release in an improved working heart preparation from guinea pigs. Circ.Res. 51:263-271, 1983

Schrader, J.: Metabolism of adenosine and sites of production in the heart. In: R.M. Berne, T.W. Rall, R. Rubio (eds.): Regulatory functions of adenosine. Martimis Nighoff, p. 133-156, 1983

Schrader, J., C.I. Thompson, G. Hiendlmayer: Role of purines in acetylcholine-induced coronary vasodilation. J.Mol.Cell.Cardiol. 14:427-430, 1982

Schrader J., Bardenheuer H.: Metabolic Regulation of Coronary Flow: Recent Aspects on the Role of Adenosine. Symposium Westerland. Sonderdruck Druchblutungsregulation und Organstoffwechsel. Akademie der Wissenschaften, Franz Steiner Verlag Wiesbaden 1982

Schrader J.; Sites of Adenosine Formation in the Heart During Hypoxia. Microcirculation of the Heart. Ed. Tillmann/Kübler/Zebe. Springer Verlag 1982

Schrader, J., H. Bardenheuer: Assessment of vasoactive metabolites released from the isolated guinea pig heart during hypoxia and ß-adrenergic stimulation. Basic Res.Cardiol. 76:365-368, 1981

Baumann, G., S. B. Felix, J. Schrader, C.D. Heidecke, G. Rieß, W.D. Erhardt, L. Ludwig, U. Loher, F. Sebening, H. Blömer: Cardiac contractile and metabolic effects mediated via the myocardial H2-receptor adenylate cyclase system. Characterization of two new specific H2-receptor agonists, impromidine and dimaprit, in the guinea pig and human myocardium.Res.Exp.Med. 179(1):81-98, 1981

Schrader, J., W. Schütz, H. Bardenheuer: Role of S-adenosylhomocysteine hydrolase in adenosine metabolism of mammalian heart. Biochem.J. 196:65-70, 1981

Strauer B. E., Schrader J., Buergr S.B.: Coronary Haemodynamics, and Myocardial Adenosine Release Under the Influence of Digitalis Glycosides (Digoxin). International Boehringer Mannheim Symposia, The Heart in Hypertension, Springer Verlag, 1981

Schrader J.: Sites of Action an Production of Adenosine at Heart. Purinergic Receptors (Receptors and Recognition, Series B, Volume 12) Chapman and Hall, 1981

Different sites of adenosine formation in the heart, Am.J.Physiol.240:H963-970, 1981 Schütz, W.; Schrader, J.; Gerlach, E.;

Schrader, J.:Interaction of AR-L-115 BS with isoprenaline on hemodynamic parameters in the isolated guinea pig heart. Arzneim.Forsch. 31:183-185, 1981

Baumann, G., J. Schrader, E. Gerlach: Inhibitory action of adenosine on cardiac contractile force and adenylate cyclase stimulated by histamine and dopamine. Circ. Res. 48:259-266, 1981

 J. Schrader, G. Baumann, E. Gerlach: Antiadrenergic Action of Adenosine in the Heart: Possible Physiological Significance. Catecholamines and the Heart. Recent Advances in Experimental an Clinical Research. Springer Verlag 1981

Joppich, R., J. Schrader, D.A. Häberle: Effect of antidiuretic hormone and dibu- tyryl cAMP upon the urinary concentrating capacity in neonatal piglets. Pediatr.Res. 14:1234-1237, 1980

Schrader, J., M. Wahl, W. Kuschinsky, G.W. Kreutzberg: Increase of adenosine content in cerebral cortex of the cat during bicuculline-induced seizure. Pflügers Arch. 387:245-251, 1980

Gerlach, E., J. Schrader, S. Nees: Sites and mode of action of adenosine in the heart: I. Coronary system. In: H.P. Baer, and G.F. Drummond (eds.) Physiological and Regulatory Functions of Adenosine and Adenine Nucleotides. Raven Press, New York, p. 127-136, 1979

Schrader, J., G. Baumann, E. Gerlach: Katecholamin-antagonistische Wirkungen von Adenosin am Herzen. In: Herzrhythmusstörungen, neue theoretische und klinische Aspekte. Schattauer Verlag, Stuttgart-New York, p. 161-175, 1979

Schrader, J.: Effects of adenosine on transmembranal Ca++-influx and adenylate cyclase of the heart. Hoppe-Seyler's Z.Physiol.Chem. 359:462, 1978

Wahl, M., J. Schrader, W. Kuschinsky: The dilatory effect of adenosine on pial arteries and its possible involvement in the regulation of cerebral blood flow. Hoppe-Seyler's Z.Physiol.Chem. 359:461-462, 1978

Schrader, J., S. Nees, E. Gerlach; Radioimmunoassay for adenosine in biological samples. Pflügers Arch. 378:167-171, 1978

Schrader, J.: Die Bedeutung von Adenosin für die Koronardurchblutung und Kontraktilität des Herzens. Fortschritte der Medizin 96:1019, 1978

Schrader, J., E. Gerlach: Formation  of  adenosine in  the isolated guinea  pig during hypoxic perfusion, autoregulation and after application of isoproterenol. Arzneim.Forsch. 27:1516-1517, 1977

Schrader J., G. Baumann, E. Gerlach: Adenosine as inhibitor of myocardial effects of catecholamines. Pflügers Arch. 372:29-35, 1977

Schrader, J., S. Nees, E. Gerlach: Evidence for a cell surface adenosine receptor on coronary myocytes and atrial muscle cells. Studies with an adenosine derivative of high molecular weight. Pflügers Arch. 369:251-257, 1977

Schrader, J., F.J. Haddy, E. Gerlach: Release of adenosine, inosine, and hypo-xanthine from the isolated guinea pig heart during reactive hyperemia, hypoxia and flow-autoregulation. Pflügers Arch. 369:1-6, 1977

Schrader, J., E. Gerlach: Compartmentation of cardiac adenine nucleotides and formation of adenosine. Pflügers Arch. 367:129-131, 1976

Schrader, J., R. Rubio, R.M. Berne: Inhibition of slow action potentials of guinea pig atrial muscle by adenosine: a possible effect on Ca++-influx. J.Mol.Cell.Cardiol. 7:427-433, 1975

Schrader, J.: Is the human erythrocyte membrane permeable to calcium? In: E. Gerlach, K. Moser, E. Deutsch, W. Wilmanns (eds.) Erythrocytes, Thrombocytes, Leucocytes. G. Thieme Publishers, p. 43-45, 1973

Schrader, J.,R.M. Berne, R. Rubio: Uptake and metabolism of adenosine by human erythrocyte ghosts. Am.J.Physiol. 223:159-166, 1972

Döring, H.I, R.R. Olbrisch, J. Schrader, H. Lang: Elektrocorticogramm, Bestandspotential des Gehirns und energiereiche Phosphatfraktionen der Hirnrinde bei Narkotikum-Überdosierung, Ischämie und Cyanidvergiftung. Pflügers Arch. 319:12-35, 1970

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