Sphingosine-1-Phosphate (S1P) promotes osteogenesis by stimulating osteoblast growth and neovascularization in a vascular endothelial growth factor (VEGF)-dependent manner
Wille A, Weske S, von Wnuck Lipinski K, Wollnitzke P, Schröder NH, Thomas N, Nowak MK, Deister-Jonas J, Behr B, Keul P, Levkau B.
J Bone Miner Res. 2024 Jan 24:zjae006. doi: 10.1093/jbmr/zjae006. Epub ahead of print. PMID: 38477738.

Sphingosine-1-phosphate suppresses GLUT activity through PP2A and counteracts hyperglycemia in diabetic red blood cells
Thomas N, Schröder NH, Nowak MK, Wollnitzke P, Ghaderi S, von Wnuck Lipinski K, Wille A, Deister-Jonas J, Vogt J, Gräler MH, Dannenberg L, Buschmann T, Westhoff P, Polzin A, Kelm M, Keul P, Weske S, Levkau B.
Nat Commun. 2023 Dec 14;14(1):8329. doi: 10.1038/s41467-023-44109-x. PMID: 38097610; PMCID: PMC10721873.

Pharmacological elevation of sphingosine-1-phosphate by S1P lyase inhibition accelerates bone regeneration after post-traumatic osteomyelitis
Wagner JM, Wille A, Fueth M, Weske S, Lotzien S, Reinkemeier F, Wallner C, Sogorski A, Dittfeld S, Becerikli M, Schildhauer TA, Lehnhardt M, Levkau B, Behr B.
J Cell Mol Med. 2023 Dec;27(23):3786-3795. doi: 10.1111/jcmm.17952. Epub 2023 Sep 14. PMID: 37710406; PMCID: PMC10718149.

An erythrocyte-centric view on the MFSD2B sphingosine-1-phosphate transporter
Ghaderi S, Levkau B.
Pharmacol Ther. 2023 Sep;249:108483. doi: 10.1016/j.pharmthera.2023.108483. Epub 2023 Jun 28. PMID: 37390971.

Revealing concealed cardioprotection by platelet Mfsd2b-released S1P in human and murine myocardial infarction
Polzin A, Dannenberg L, Benkhoff M, Barcik M, Helten C, Mourikis P, Ahlbrecht S, Wildeis L, Ziese J, Zikeli D, Metzen D, Hu H, Baensch L, Schröder NH, Keul P, Weske S, Wollnitzke P, Duse D, Saffak S, Cramer M, Bönner F, Müller T, Gräler MH, Zeus T, Kelm M, Levkau B.
Nat Commun. 2023 Apr 26;14(1):2404. doi: 10.1038/s41467-023-38069-5. PMID: 37100836; PMCID: PMC10133218.

Sphingosine-1-Phosphate (S1P) Lyase Inhibition Aggravates Atherosclerosis and Induces Plaque Rupture in ApoE^-/- Mice
Keul P, Peters S, von Wnuck Lipinski K, Schröder NH, Nowak MK, Duse DA, Polzin A, Weske S, Gräler MH, Levkau B.
Int J Mol Sci. 2022 Aug 24;23(17):9606. doi: 10.3390/ijms23179606. PMID: 36077004; PMCID: PMC9455951.

Agonist-induced activation of the S1P receptor 2 constitutes a novel osteoanabolic therapy for the treatment of osteoporosis in mice
Weske S, Vaidya M, von Wnuck Lipinski K, Keul P, Manthe K, Burkhart C, Haberhauer G, Heusch G, Levkau B.
Bone. 2019 Aug;125:1-7. doi: 10.1016/j.bone.2019.04.015. Epub 2019 Apr 24. PMID: 31028959

Regulation of ABCA1-mediated cholesterol efflux by sphingosine-1-phosphate signaling in macrophages.
Vaidya M, Jentsch JA, Peters S, Keul P, Weske S, Gräler MH, Mladenov E, Iliakis G, Heusch G, Levkau B.
J Lipid Res. 2019 Mar;60(3):506-515. doi: 10.1194/jlr.M088443. Epub 2019 Jan 17. PMID: 30655318; PMCID: PMC6399502.

Potent anti-inflammatory properties of HDL in vascular smooth muscle cells mediated by HDL-S1P and their impairment in coronary artery disease due to lower HDL-S1P: a new aspect of HDL dysfunction and its therapy. 
Keul P, Polzin A, Kaiser K, Gräler M, Dannenberg L, Daum G, Heusch G, Levkau B.
FASEB J. 2019 Jan;33(1):1482-1495. doi: 10.1096/fj.201801245R. Epub 2018 Aug 21. PMID: 30130432.

Targeting sphingosine-1-phosphate lyase as an anabolic therapy for bone loss.
Weske S, Vaidya M, Reese A, von Wnuck Lipinski K, Keul P, Bayer JK, Fischer JW, Flögel U, Nelsen J, Epple M, Scatena M, Schwedhelm E, Dörr M, Völzke H, Moritz E, Hannemann A, Rauch BH, Gräler MH, Heusch G, Levkau B.
Nat Med. 2018 May;24(5):667-678. doi: 10.1038/s41591-018-0005-y. Epub 2018 Apr 16. PMID: 29662200.

Hepatocyte nuclear factor 1A deficiency causes hemolytic anemia in mice by altering erythrocyte sphingolipid homeostasis
von Wnuck Lipinski K, Weske S, Keul P, Peters S, Baba HA, Heusch G, Gräler MH, Levkau B.
Blood. 2017 Dec 21;130(25):2786-2798. doi: 10.1182/blood-2017-03-774356. Epub 2017 Nov 6. PMID: 29109103.

Hepatocyte Nuclear Factor 1A Is a Cell-Intrinsic Transcription Factor Required for B Cell Differentiation and Development in Mice
von Wnuck Lipinski K, Sattler K, Peters S, Weske S, Keul P, Klump H, Heusch G, Göthert JR, Levkau B.
J Immunol. 2016 Feb 15;196(4):1655-65. doi: 10.4049/jimmunol.1500897. Epub 2016 Jan 22. PMID: 26800876.

Sphingosine-1-Phosphate Receptor 1 Regulates Cardiac Function by Modulating Ca2+ Sensitivity and Na+/H+ Exchange and Mediates Protection by Ischemic Preconditioning
Keul P, van Borren MM, Ghanem A, Müller FU, Baartscheer A, Verkerk AO, Stümpel F, Schulte JS, Hamdani N, Linke WA, van Loenen P, Matus M, Schmitz W, Stypmann J, Tiemann K, Ravesloot JH, Alewijnse AE, Hermann S, Spijkers LJ, Hiller KH, Herr D, Heusch G, Schäfers M, Peters SL, Chun J, Levkau B.
J Am Heart Assoc. 2016 May 20;5(5):e003393. doi: 10.1161/JAHA.116.003393. PMID: 27207969; PMCID: PMC4889204.

Defects of High-Density Lipoproteins in Coronary Artery Disease Caused by Low Sphingosine-1-Phosphate Content: Correction by Sphingosine-1-Phosphate-Loading
Sattler K, Gräler M, Keul P, Weske S, Reimann CM, Jindrová H, Kleinbongard P, Sabbadini R, Bröcker-Preuss M, Erbel R, Heusch G, Levkau B.
J Am Coll Cardiol. 2015 Sep 29;66(13):1470-85. doi: 10.1016/j.jacc.2015.07.057. PMID: 26403344.

Sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin
Nussbaum C, Bannenberg S, Keul P, Gräler MH, Gonçalves-de-Albuquerque CF, Korhonen H, von Wnuck Lipinski K, Heusch G, de Castro Faria Neto HC, Rohwedder I, Göthert JR, Prasad VP, Haufe G, Lange-Sperandio B, Offermanns S, Sperandio M, Levkau B.
Nat Commun. 2015 Apr 2;6:6416. doi: 10.1038/ncomms7416. PMID: 25832730; PMCID: PMC4396399.