original articles in peer-reviewed journals

 

 

Trads JB, Hüll K, Matsuura BS, Laprell L, Fehrentz T, Görldt N, Kozek KA, Weaver CD, Klöcker N, Barber DM, Trauner D. Sign Inversion in Photopharmacology: Incorporation of Cyclic Azobenzenes in Photoswitchable Potassium Channel Blockers and Openers. Angew Chem Int Ed Engl. 2019 Oct 21;58(43):15421-15428. doi: 10.1002/anie.201905790. Epub 2019 Sep 12. Review.
PubMed

Lu K, Zimmermann M, Görg B, Bidmon HJ, Biermann B, Klöcker N, Häussinger D, Reichert AS
Hepatic encephalopathy is linked to alterations of autophagic flux in astrocytes. AS.EBioMedicine. 2019 Oct;48:539-553. doi: 10.1016/j.ebiom.2019.09.058. Epub 2019 Oct 21.
PubMed

Koch A, Bonus M, Gohlke H, Klöcker N. Isoform-specific Inhibition of N-methyl-D-aspartate Receptors by Bile Salts. Sci Rep. 2019 Jul 11;9(1):10068. doi: 10.1038/s41598-019-46496-y.
PubMed

Scherschel K, Hedenus K, Jungen C, Lemoine MD, Rübsamen N, Veldkamp MW, Klatt N, Lindner D, Westermann D, Casini S, Kuklik P, Eickholt C, Klöcker N, Shivkumar K, Christ T, Zeller T, Willems S, Meyer C. Cardiac glial cells release neurotrophic S100B upon catheter-based treatment of atrial fibrillation. Sci Transl Med. 2019 May 22;11(493). pii: eaav7770. doi: 10.1126/scitranslmed.aav7770.
PubMed 

Mölders A, Koch A, Menke R, Klöcker N. Heterogeneity of the astrocytic AMPA-receptor transcriptome. Glia. 2018 Dec;66(12):2604-2616. doi: 10.1002/glia.23514. Epub 2018 Oct 28.
PubMed

Haselmann H, Mannara F, Werner C, Planagumà J, Miguez-Cabello F, Schmidl L, Grünewald B, Petit-Pedrol M, Kirmse K, Classen J, Demir F, Klöcker N, Soto D, Doose S, Dalmau J, Hallermann S, Geis C. Human Autoantibodies against the AMPA Receptor Subunit GluA2 Induce Receptor Reorganization and Memory Dysfunction. Neuron. 2018 Oct 10;100(1):91-105.e9. doi: 10.1016/j.neuron.2018.07.048. Epub 2018 Aug 23.
PubMed

Clasen L, Eickholt C, Angendohr S, Jungen C, Shin DI, Donner B, Fürnkranz A, Kelm M, Klöcker N, Meyer C, Makimoto H. A modified approach for programmed electrical stimulation in mice: Inducibility of ventricular arrhythmias. PLoS One. 2018 Aug 22;13(8):e0201910. doi: 10.1371/journal.pone.0201910. eCollection 2018.
PubMed

Krüger K, Geist K, Stuhldreier F, Schumacher L, Blümel L, Remke M, Wesselborg S, Stork B, Klöcker N, Bormann S, Roos WP, Honnen S, Fritz G. (2018)  Multiple DNA damage-dependent and DNA damage-independent stress responses define the outcome of ATR/Chk1 targeting in medulloblastoma cells.Cancer Lett. 2018;430: 34-46
PubMed

Eickholt C, Jungen C, Drexel T, Alken F, Kuklik P, Muehlsteff J, Makimoto H, Hoffmann B, Kelm M, Ziegler D, Kloecker N, Willems S, Meyer C. (2018) Sympathetic and Parasympathetic Coactivation Induces Perturbed Heart Rate Dynamics in Patients with Paroxysmal Atrial Fibrillation. Med Sci Monit. 2018;24: 2164-2172
PubMed

Fehrentz T, Huber FME, Hartrampf N, Bruegmann T, Frank JA, Fine NHF, Malan D, Danzl JG, Tikhonov DB,Sumser M, Sasse P, Hodson DJ, Zhorov BS, Klöcker N, Trauner D (2018) Optical control of L-type Ca2+ channels using a diltiazem photoswitch. Nat Chem Biol. 2018;14(8): 764-767
PubMed

Malviya M, Barman S, Golombeck KS, Planagumà J, Mannara F, Strutz-Seebohm N, Wrzos C, Demir F, Baksmeier C, Steckel J, Falk KK, Gross CC, Kovac S, Bönte K, Johnen A, Wandinger KP, Martín-García E, Becker AJ, Elger CE, Klöcker N, Wiendl H, Meuth SG, Hartung HP, Seebohm G, Leypoldt F, Maldonado R, Stadelmann C, Dalmau J, Melzer N, Goebels N. NMDAR encephalitis: passive transfer from man to mouse by a recombinant antibody. Ann Clin Transl Neurol. 2017 Oct 3;4(11):768-783. doi: 10.1002/acn3.444. eCollection 2017 Nov.
PubMed

 

Jungen C, Scherschel K, Eickholt C, Kuklik P, Klatt N, Bork N, Salzbrunn T, Alken F, Angendohr S, Klene C, Mester J, Klöcker N, Veldkamp MW, Schumacher U, Willems S, Nikolaev VO, Meyer C. Disruption of cardiac cholinergic neurons enhances susceptibility to ventricular arrhythmias. Nat Commun. 2017 Jan 27;8:14155. doi: 10.1038/ncomms14155.
PubMed

Chepkova AN, Sergeeva OA, Görg B, Haas HL, Klöcker N, Häussinger D (2017) Impaired novelty acquisition and synaptic plasticity in congenital hyperammonemia caused by hepatic glutamine synthetase deficiency. Sci Rep.doi:10.1038/srep40190
PubMed

Birgit Hoffmann, Nikolaj Klöcker, Klaus Benndorf, Christoph Biskup (2015) Visualization of the dynamics of PSD-95 and Kir2.1 interaction by fluorescence lifetime-based resonance energy transfer imaging. Medical Photonics 27, 70-82

Kleinbongard P, Gedik N, Witting P, Freedman B, Klöcker N, Heusch G (2015) Pleiotropic, heart rate-independent cardioprotection by ivabradine. Br J Pharmacol. doi: 10.1111/bph. 13220
PubMed

Schroeter A, Wen S, Mölders A, Erlenhardt N, Stein V, Klöcker N.Depletion of the AMPAR reserve pool impairs synaptic plasticity in a model of hepatic encephalopathy. Mol Cell Neurosci. 2015 Sep;68:331-9. doi: 10.1016/j.mcn.2015.09.001. Epub 2015 Sep 9.
PubMed

Marquard J, Otter S, Welters A, Stirban A, Fischer A, Eglinger J, Herebian D, Kletke O, Klemen MS, Stozer A, Wnendt S, Piemonti L, Köhler M, Ferrer J, Thorens B, Schliess F, Rupnik MS, Heise T, Berggren PO, Klöcker N, Meissner T, Mayatepek E, Eberhard D, Kragl M, Lammert E (2015) Characterization of pancreatic NMDA receptors as possible drug targets for diabetes treatment. Nat Med. 21(4); 363-72
PubMed

Wen S, Schroeter A, Klöcker N. (2013) Synaptic plasticity in hepatic encephalopathy - a molecular perspective.  Arch Biochem Biophys. 536(2):183-8.
PubMed

Mauric V, Mölders A, Harmel N, Heimrich B, Sergeeva OA, Klöcker N. (2013) Ontogeny repeats the phylogenetic recruitment of the cargo exporter cornichon into AMPA receptor signaling complexes. Mol Cell Neurosci. 56:1
PubMed

Netter MF, Zuzarte M, Schlichthoerl G, Klöcker N, Decher N (2012) The HCN4 channel mutation D553N associated with bradycardia has a C-linker mediated gating Defect. Cell Physiol Biochem 30(5):1227-1240.
PubMed

Schwenk J, Harmel N, Brechet A, Zolles G, Berkefeld H, Müller CS, Bildl W, Baehrens D, Hüber B, Kulik A, Klöcker N, Schulte U, Fakler B (2012). High-resolution proteomics unravel architecture and molecular diversity of native AMPA receptor complexes. Neuron 74(4):621-33. 
PubMed

Harmel N, Cokic N, Zolles G, Berkefeld H, Mauric V, Fakler B, Stein V, Klöcker N (2012) AMPA receptors commandeer an ancient cargo exporter for use as an auxiliary subunit for signaling. PLoS One 7(1):e30681. Epub 2012 Jan 24.
PubMed

 

2006 - 2010

Zolles G, Wenzel D, Bildl W, Schulte U, Hofmann A, Müller CS, Thumfart J, Vlachos A, Deller T, Pfeifer A, Fleischmann BK, Roeper J, Fakler B, Klöcker N (2009) Association with the auxiliary subunit PEX5R/Trip8b controls responsiveness of HCN channels to cAMP and adrenergic stimulation Neuron62(6):814-25.
PubMed

Schwenk J, Harmel N, Zolles G, Bildl W, Kulik A, Heimrich B, Chisaka O, Jonas P, Schulte U, Fakler B, Klöcker N (2009) Functional proteomics identify cornichon proteins as auxiliary subunits of AMPA receptors. Science 323(5919):1313-9.
PubMed

Hardel N, Harmel N, Zolles G, Fakler B, Klöcker N (2008) Recycling endosomes supply HCN channels for rapid adaptation of their surface expression. Cardiovasc Res 79(1):52-60.
PubMed

Kaufhold MA, Krabbenhöft A, Song P, Engelhardt R, Riederer B, Fährmann M, Klöcker N, Beil W, Manns M, Hagen SJ, Seidler U (2008) Localization, trafficking and significance for acid secretion of parietal cell Kir4.1 and KCNQ1 K+ channels. Gastroenterology 134(4):1058-69.
PubMed

Hoffmann B, Zimmer T, Klöcker N, Kelbauskas L, König K, Benndorf K, Biskup C (2008) Prolonged irradiation of ECFP or Cerulean can invalidate FRET measurements. J Biomed Opt 13(3):031205.
PubMed

Biskup C, Zimmer T, Kelbauskas L, Hoffmann B, Klöcker N, Becker W, Bergmann A, Benndorf K (2007) Multi-Dimensional Fluorescence Lifetime and FRET Measurements. Microsc Res Tech 70(5):442-51.
PubMed

Zolles G, Klöcker N, Wenzel D, Weisser-Thomas J, Fleischmann BK, Roeper J, Fakler B (2006) Pacemaking by HCN channels requires interaction with phosphoinositides. Neuron 52(6):1027-36.
PubMed

Shumilina E, Klöcker N, Korniychuk G, Rapedius M, Lang F, Baukrowitz T (2006) Cytoplasmic accumulation of long chain CoA Esters activate KATP and inhibit Kir2.1 channels J Physiol 575:433-42.
PubMed

Schulte U, Thumfart JO, Klöcker N, Sailer CA, Bildl W, Biniossek M, Dehn D, Deller T, Eble S, Abbass K, Wangler T, Knaus HG, Fakler B (2006) The epilepsy-linked Lgi1 protein assembles into presynaptic Kv1 channels and inhibits inactivation by Kvbeta1. Neuron 49(5):697-706.
PubMed

Becker W, Bergmann A, Haustein E, Petrasek Z, Schwille P, Biskup C, Kelbauskas L, Benndorf KKlöcker N, Anhut T, Riemann I, König K (2006) Fluorescence lifetime images and correlation spectra obtained by multidimensional time-correlated single photon counting. Microsc Res Tech 69(3):186-95.
PubMed

 

2001 - 2005

Hofherr A, Fakler B, Klöcker N (2005) Selective Golgi export of Kir2.1 controls the functional stoichiometry of Kir2.x channels. J Cell Sci 118:1935-43.
PubMed

Noel G, Belda M, Guadagno E, Micoud J, Klöcker N, Moukhles H (2005) Dystroglycan and Kir4.1 co-clustering in retinal Müller glia is differentially regulated by laminin-1 and C-agrin and requires the PDZ-ligand domain of Kir4.1. J Neurochem 94(3):691-702.
PubMed

Weishaupt JH, Klöcker N, Bähr M (2005) Axotomy-induced early down-regulation of POU-IV class transcription factors Brn-3a and Brn-3b in retinal ganglion cells. J Mol Neurosci 26(1):17-25.
PubMed

Reisinger E, Zimmermann U, Knipper M, Ludwig J, Klöcker N, Fakler B, Oliver D (2005). Cod106, a novel synaptic protein expressed in sensory hair cells of the inner ear and in CNS neurons. Mol Cell Neurosci 28(1):106-17.
PubMed

Biskup C Kelbauskas L, Zimmer T, Stockklausner C, Bergmann A, Becker W, Ruppersberg JP, Benndorf K, Klöcker N (2004). Interaction of PSD-95 with potassium channels visualized by fluorescence-lifetime based resonance energy transfer imaging. J Biomed Opt 9(4):753-9.
PubMed

Matsuda K, Zheng J, Du GG, Klöcker N, Madison LD, Dallos P (2004) N-linked glycosylation sites of the motor protein: effects on electrophysiological function. J Neurochem 89(4):928-38.
PubMed

Stockklausner C and Klöcker N (2003). Surface expression of inward rectifier potassium channels is controlled by selective Golgi export. J Biol Chem 278(19):17000-5.
PubMed

Klöcker N, Bunn RC, Schnell E, Caruana G, Bernstein A, Nicoll RA, Bredt DS (2002) Synaptic glutamate receptor clustering in mice lacking the SH3 and GK domains of SAP97. Eur J Neurosci 16(8):1517-22.
PubMed

Wissmann R, Bildl W, Neumann H, Rivard AF, Klöcker N, Weitz D, Schulte U, Adelman JP, Bentrop D, Fakler B (2002) A helical region in the C terminus of small-conductance Ca2+-activated K+ channels controls assembly with apo-calmodulin. J Biol Chem 277(6):4558-64.
PubMed

Kermer P, Klöcker N, Bähr M (2001) Modulation of metabotropic glutamate receptors fails to prevent the loss of adult rat retinal ganglion cells following axotomy or N-methyl-D-aspartate lesion in vivo. Neurosci Lett 315(3):117-20.
PubMed

Klöcker N, Zerfowski M, Gellrich NC, Bähr M (2001) Morphological and functional analysis of an incomplete CNS fiber tract lesion: graded crush of the rat optic nerve. J Neurosci Methods 110(1-2):147-53.
PubMed

Oliver D, He DZZ, Klöcker N, Ludwig J, Schulte U, Waldegger S, Ruppersberg JP, Dallos P, Fakler B (2001) Intracellular anions as the voltage-sensor of prestin, the outer hair cell motor protein. Science 292:2340-2343.
PubMed

Kermer P, Klöcker N, Weishaupt JH, Bähr M (2001) Transection of the optic nerve in rats: Studying neuronal death and survival in vivo. Brain Res Protocols 7(3):255-260.
PubMed

Stockklausner C, Ludwig J, Ruppersberg JP, Klöcker N (2001) A sequence motif responsible for ER export and surface expression of Kir2.0 inward rectifier K+ channels. FEBS Lett 493(2-3):129-33.
PubMed

Ludwig J, Oliver D, Frank G, Klöcker N, Gummer AW, Fakler B (2001) The reciprocal electromechanical properties of rat prestin: the motor molecule of rat outer hair cells. Proc Nat Acad Sci USA 98(7):4178-83.
PubMed

Klöcker N, Oliver D, Ruppersberg JP, Knaus HG, Fakler B (2001) Developmental expression of the small conductance Ca2+-activated potassium channel SK2 in the rat retina. Mol Cell Neurosci 17(3):514-20.
PubMed

 

1996 - 2000

Kermer P, Ankerhold R, Klöcker N, Krajewski S, Reed JC, Bähr M (2000) Caspase-9: Involvement in secondary death of axotomized rat retinal ganglion cells in vivoBrain Res Mol Brain Res 85(1-2):144-150.
PubMed

Klöcker N, Jung M, Stuermer CAO, Bähr M (2001) BDNF increases the number of axotomized rat retinal ganglion cells expressing GAP-43, L1, and TAG-1 mRNA - a supportive role for nitric oxide? Neurobiol Dis 8(1):103-13.
PubMed

Klöcker N, Kermer P, Weishaupt JH, Labes M, Ankerhold R, Bähr M (2000) Brain-derived neurotrophic factor-mediated neuroprotection of adult rat retinal ganglion cells in vivo does not exclusively depend on phosphatidyl-inositol-3’-kinase/protein kinase B signaling. J Neurosci 20(18):6962-6967.
PubMed

Oliver D, Klöcker N, Schuck J, Baukrowitz T, Ruppersberg JP, Fakler B (2000) Gating of Ca2+-activated K+ channels controls fast inhibitory synaptic transmission at auditory outer hair cells. Neuron 26:1-20.
PubMed

Weise J, Isenmann S, Klöcker N, Kügler S, Hirsch S, Gravel C, Bähr M. (2000) Adenovirus-mediated expression of ciliary neurotrophic factor (CNTF) rescues axotomized rat retinal ganglion cells but does not support axonal regeneration in vivo. Neurobiol Dis 7(3):212-223.
PubMed

Kermer P, Klöcker N, Labes M, Bähr M (2000) Insulin-like growth factor-I protects axotomized rat retinal ganglion cells from secondary death via PI3K-dependent Akt-phosphorylation and inhibition of caspase-3 in vivoJ Neurosci 20(2):722-728.
PubMed

Klöcker N, Kermer P, Gleichmann M, Weller M, Bähr M (1999) Both the neuronal and inducible isoform contribute to upregulation of retinal NOS activity by BDNF. J Neurosci 19(19):8517-8527.
PubMed

Kügler S, Klöcker N, Kermer P, Isenmann S, Bähr M (1999) Transduction of retinal ganglion cells by adenoviral vector administration at the optic nerve stump: an in vivo model system for the inhibition of neuronal apoptotic cell death. Gene Ther 6(10):1759-1767.
PubMed

Kermer P, Klöcker N, Labes M, Thomsen S, Srinivasan A, Bähr M (1999) Activation of caspase-3 in axotomized rat retinal ganglion cells in vivoFEBS Lett 453(3):361-364.
PubMed

Kermer P, Klöcker N, Bähr M (1999) Long-term effect of inhibition of ced 3-like caspases on the survival of axotomized retinal ganglion cells in vivoExp Neurol 158(1):202-205.
PubMed

Klöcker N, Cellerino A, Bähr M (1998) Free radical scavenging and inhibition of nitric oxide synthase potentiates the neurotrophic effects of brain-derived neurotrophic factor on axotomized retinal ganglion cells in vivoJ Neurosci 18 (3):1038-1046.
PubMed

Kermer P, Klöcker N, Labes M, Bähr M (1998) Inhibition of CPP32-like proteases rescues axotomized retinal ganglion cells from secondary cell death in vivo. J Neurosci 18 (12):4656-4662.
PubMed

Isenmann S, Klöcker N, Gravel C, Bähr M. (1998) Protection of axotomized retinal ganglion cells by adenovirally delivered BDNF in vivoEur J Neurosci 10:2751-2756.
PubMed

Klöcker N, Bräunling F, Isenmann S, Bähr M (1997) In vivo neurotrophic effects of GDNF on axotomized retinal ganglion cells. NeuroReport 8:3439-3442.
PubMed

Klöcker N, Mußhoff U, Madeja M, Speckmann EJ (1996) Activation of ATP-sensitive potassium channels in follicle-enclosed Xenopus oocytes by the epileptogenic agent pentylenetetrazol. Pflügers Arch 431:736-740.
PubMed

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