Publikationen 2020

Hoser SM, Hoffmann A, Meindl A, Gamper M, Fallmann J, Bernhart SH, Müller L, Ploner M, Misslinger M, Kremser L, Lindner H, Geley S, Schaal H, Stadler PF, Huettenhofer A.  Intronic tRNAs of mitochondrial origin regulate constitutive and alternative splicing.  Genome Biol. 2020 Dec 8;21(1):299.

Ptok J, Theiss S, Schaal H.  VarCon: An R Package for Retrieving Neighboring Nucleotides of an SNV. Cancer Inform. 2020 Nov 24;19:1176935120976399.

Ramani A, Müller L, Ostermann PN, Gabriel E, Abida-Islam P, Müller-Schiffmann A, Mariappan A, Goureau O, Gruell H, Walker A, Andrée M, Hauka S, Houwaart T, Dilthey A, Wohlgemuth K, Omran H, Klein F, Wieczorek D, Adams O, Timm J, Korth C, Schaal H, Gopalakrishnan, J. SARS-CoV-2 targets neurons of 3D human brain organoids. EMBO J. 2020 Oct 15;39(20):e106230.

Luteijn RD, Praest P, Thiele F, Sadasivam SM, Singethan K, Drijfhout JW, Bach C, de Boer SM, Lebbink RJ, Tao S, Helfer M, Bach NC, Protzer U, Costa AI, Killian JA, Drexler I, Wiertz EJHJ.  A Broad-Spectrum Antiviral Peptide Blocks Infection of Viruses by Binding to Phosphatidylserine in the Viral Envelope. Cells. 2020 Aug 29;9(9):1989.

Raguz N, Heim A, Engal E, Wesche J, Merl-Pham J, Hauck SM, Erkelenz S, Schaal H, Bensaude O, Wolf A, Salton M, Böttger A. JMJD6 Regulates Splicing of Its Own Gene Resulting in Alternatively Spliced Isoforms with Different Nuclear Targets. Int J Mol Sci. 2020 Sep 10;21(18):6618.

Wiatr M, Figueiredo R, Stump-Guthier C, Winter P, Ishikawa H, Adams O, Schwerk C, Schroten H, Rudolph H, Tenenbaum T. Polar Infection of Echovirus-30 Causes Differential Barrier Affection and Gene Regulation at the Blood-Cerebrospinal Fluid Barrier. Int J Mol Sci. 2020 Aug 29;21(17):6268.

Sarrazin C, Zimmermann T, Berg T, Hinrichsen H, Mauss S, Wedemeyer H, Zeuzem S; Deutsche Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS); Deutsche Gesellschaft für Pathologie e. V. (DGP) und Bundesverband Deutscher Pathologen (BDP); Deutsche Leberstiftung; Gesellschaft für Virologie e. V. (GfV); Gesellschaft für Pädiatrische Gastroenterologie und Ernährung (GPGE); Österreichische Gesellschaft für Gastroenterologie und Hepatologie (ÖGGH); Schweizerische Gesellschaft für Gastroenterologie (SGG); Deutsche Transplantationsgesellschaft e. V. (DTG); Deutsche Leberhilfe e. V.; Deutsche Gesellschaft für Infektiologie e. V. (DGI); Deutsche Gesellschaft für Suchtmedizin e. V. (DGS); Deutsche AIDS-Gesellschaft e. V. (DAIG); Deutsche Arbeitsgemeinschaft niedergelassener Ärzte für die Versorgung HIV-Infizierter (DAGNÄ); Robert Koch-Institut (RKI); Collaborators. Prophylaxe, Diagnostik und Therapie der Hepatitis-C-Virus(HCV)-Infektion. Z Gastroenterol. 2020 Nov;58(11):1110-1131.

Lübke N, Senff T, Scherger S, Hauka S, Andrée M, Adams O, Timm J, Walker A.  Extraction-free SARS-CoV-2 detection by rapid RT-qPCR universal for all primary respiratory materials. J Clin Virol. 2020 Aug 5;130:104579.

Barnowski C, Ciupka G, Tao R, Jin L, Busch DH, Tao S, Drexler I. Efficient Induction of Cytotoxic T Cells by Viral Vector Vaccination Requires STING-Dependent DC Functions. Front Immunol. 2020 Jul 16;11:1458.

Alm E, Broberg EK, Connor T, Hodcroft EB, Komissarov AB, Maurer-Stroh S, Melidou A, Neher RA, O'Toole Á, Pereyaslov D; WHO European Region sequencing laboratories and GISAID EpiCoV group; WHO European Region sequencing laboratories and GISAID EpiCoV group*. Geographical and temporal distribution of SARS-CoV-2 clades in the WHO European Region, January to June 2020.  Euro Surveill. 2020 Aug;25(32):2001410.

Rose MA, Barker M, Liese J, Adams O, Ankermann T, Baumann U, Brinkmann F, Bruns R, Dahlheim M, Ewig S, Forster J, Hofmann G, Kemen C, Lück C, Nadal D, Nüßlein T, Regamey N, Riedler J, Schmidt S, Schwerk N, Seidenberg J, Tenenbaum T, Trapp S, van der Linden M. [Guidelines for the Management of Community Acquired Pneumonia in Children and Adolescents (Pediatric Community Acquired Pneumonia, pCAP) - Issued under the Responsibility of the German Society for Pediatric Infectious Diseases (DGPI) and the German Society for Pediatric Pulmonology (GPP)].  Pneumologie. 2020 Aug;74(8):515-544.

Erkelenz S, Poschmann G, Ptok J, Müller L, Schaal H. Profiling of cis- and trans-acting factors supporting noncanonical splice site activation.  RNA Biol. 2020 Aug 5:1-13.

Holtmann N, Edimiris P, Andree M, Doehmen C, Baston-Buest D, Adams O, Kruessel JS, Bielfeld AP  Assessment of SARS-CoV-2 in human semen-a cohort study. Fertil Steril. 2020 Aug;114(2):233-238.

Goereci Y, Schweitzer F, Wellstein A, Silling S, Borchmann S, von Tresckow B, Adams O, Martin R, Schlamann M, Schroeter M, Fink GR, Wattjes MP, Warnke C. Clearance of JC polyomavirus from cerebrospinal fluid following treatment with interleukin-2 and pembrolizumab in an individual with progressive multifocal leukoencephalopathy and no underlying immune deficiency syndrome. Eur J Neurol. 2020 Nov;27(11):2375-2377.

Steuwe A, Rademacher C, Valentin B, Koehler MH, Appel E, Keitel V, Timm J, Antoch G, Aissa J. Dose optimized chest CT for diagnosis of COVID-19 - Evaluation of the image quality and diagnostic impact. J Radiol Prot. 2020 Sep;40(3):877-891

Walker A, Houwaart T, Wienemann T, Vasconcelos MK, Strelow D, Senff T, Hülse L, Adams O, Andree M, Hauka S, Feldt T, Jensen BE, Keitel V, Kindgen-Milles D, Timm J, Pfeffer K, Dilthey AT. Genetic structure of SARS-CoV-2 reflects clonal superspreading and multiple independent introduction events, North-Rhine Westphalia, Germany, February and March 2020.  Euro Surveill. 2020 Jun;25(22):2000746.

Kloetgen A, Duggimpudi S, Schuschel K, Hezaveh K, Picard D, Schaal H, Remke M, Klusmann JH, Borkhardt A, McHardy AC, Hoell JI.  YBX1 Indirectly Targets Heterochromatin-Repressed Inflammatory Response-Related Apoptosis Genes through Regulating CBX5 mRNA. Int J Mol Sci. 2020 Jun 23;21(12):4453

Corman VM, Rabenau HF, Adams O, Oberle D, Funk MB, Keller-Stanislawski B, Timm J, Drosten C, Ciesek S. SARS-CoV-2 asymptomatic and symptomatic patients and risk for transfusion transmission. Transfusion. 2020 Jun;60(6):1119-1122

Grutza R, Moskorz W, Senff T, Bäcker E, Lindemann M, Zimmermann A, Uhrberg M, Lang PA, Timm J, Cosmovici C. NKG2Cpos NK Cells Regulate the Expansion of Cytomegalovirus-Specific CD8 T Cells. J Immunol. 2020 Jun 1;204(11):2910-2917.

Schmitz J, Kobbe G, Kondakci M, Schuler E, Magorsch M, Adams O. The Value of Torque Teno Virus (TTV) as a Marker for the Degree of Immunosuppression in Adult Patients after Hematopoietic Stem Cell Transplantation (HSCT). Biol Blood Marrow Transplant. 2020 Apr;26(4):643-650.

Tao S, Drexler I. Targeting Autophagy in Innate Immune Cells: Angel or Demon During Infection and Vaccination?  Front Immunol. 2020 Mar 19;11:460.

Scheffel F, Knuschke T, Otto L, Kollenda S, Sokolova V, Cosmovici C, Buer J, Timm J, Epple M, Westendorf AM. Effective Activation of Human Antigen-Presenting Cells and Cytotoxic CD8+ T Cells by a Calcium Phosphate-Based Nanoparticle Vaccine Delivery System.  Vaccines (Basel). 2020 Mar 1;8(1):E110.

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