Publikationen 2021

Müller L, Moskorz W, Brillen AL, Hillebrand F, Ostermann PN, Kiel N, Walotka L, Ptok J, Timm J, Lübke N, Schaal H. Altered HIV-1 mRNA Splicing Due to Drug-Resistance-Associated Mutations in Exon 2/2b. Int J Mol Sci. 2021 Dec 23;23(1):156.

Senff T, Menne C, Cosmovici C, Lewis-Ximenez LL, Aneja J, Broering R, Kim AY, Westendorf AM, Dittmer U, Scherbaum N, Lauer GM, Timm J. Peripheral blood iNKT cell activation correlates with liver damage during acute hepatitis C. JCI Insight. 2021 Dec 14:e155432.

Backhaus I, Hermsen D, Timm J, Boege F, Lübke N, Göbels K, von der Lieth D, Dragano N. Underascertainment of COVID-19 cases among first responders: a seroepidemiological study. Occup Med (Lond). 2021 Dec 9:kqab164.

Selvarajah S, Lingappa AF, Michon M, Du L, Deiter F, Yu SF, Macieik A, Mallesh S, Appaiah U, Crabtree J, Copeland K, Müller-Schiffmann A, Müller L, Ostermann PN, Andrée M, Adams O, Schaal H, Hogan RJ, Tripp RA, Anand SK, Campi TW, Ford MJ, Reed JC, Lin J, Akintunde O, Nichols C, Petrouski E, Moreira AR, Jiang IT, DeYarman N, Broce S, Brown I, Lau S, Segal I, Goldsmith D, Hong S, Asundi V, Briggs EM, Phyo NS, Froehlich M, Onisko B, Matlack K, Dey D, Lingappa JR, Prasad MD, Korth C, Kitaygorodskyy A, Solas D, Boushey H, Greenland J, Pillai S, Paulvannan K, Lingappa VR. From COVID-19 to the Common Cold: Novel Host-Targeted, Pan-Respiratory Antiviral Small Molecule Therapeutics. bioRxiv. 2021 Dec 13:2021.01.17.426875.

Kaynarcalidan O, Moreno Mascaraque S, Drexler I.  Vaccinia Virus: From Crude Smallpox Vaccines to Elaborate Viral Vector Vaccine Design. Biomedicines. 2021 Nov 26;9(12):1780. 

Hottenträger B, Hagedorn HJ, Bäcker E, Bleekmann B, Gessner A, Lübke N, Wenzel JJ, Widera M, Pabinger S, Ramge P, Timm J. Multicenter Performance Evaluation of Elecsys Anti-HBc II, Anti-HCV II, HIV combi PT, HBsAg II, and Syphilis Immunoassays. Clin Lab. 2021 Nov 1;67(11).

Müller L, Andrée M, Ostermann PN, Jazmati N, Flüh G, Fischer JC, Bölke E, Heger E, Vanshylla K, Klein F, Wisplinghoff H, Schaal H, Drexler I, Walker A, Adams O, Timm JSARS-CoV-2 Infection in Fully Vaccinated Individuals of Old Age Strongly Boosts the Humoral Immune Response. Front Med (Lausanne). 2021 Oct 11;8:746644.

Adams O, Andrée M, Rabl D, Ostermann PN, Schaal H, Lehnert E, Ackerstaff S, Müller L, Fischer JC. Humoral response to SARS-CoV-2 and seasonal coronaviruses in COVID-19 patients. J Med Virol. 2021 Oct 30:10.1002/jmv.27427.

Erbel-Khurtsidze S, Immohr MB, Akhyari P, Tudorache I, Aubin H, Bruno RR, Westenfeld R, Feldt T, Lübke N, Lichtenberg A, Boeken U. Adequate immune response after SARS-CoV-2 infection and single dose vaccination despite rapid heart transplantation. ESC Heart Fail. 2021 Dec;8(6):5568-5571.

Fischer B, Lichtenberg C, Müller L, Timm J, Fischer J, Knabbe C. A combined strategy to detect plasma samples reliably with high anti-SARS-CoV-2 neutralizing antibody titers in routine laboratories. J Clin Virol. 2021 Nov;144:104984.

Debisarun PA, Gössling KL, Bulut O, Kilic G, Zoodsma M, Liu Z, Oldenburg M, Rüchel N, Zhang B, Xu CJ, Struycken P, Koeken VACM, Domínguez-Andrés J, Moorlag SJCFM, Taks E, Ostermann PN, Müller L, Schaal H, Adams O, Borkhardt A, Ten Oever J, van Crevel R, Li Y, Netea MG. Induction of trained immunity by influenza vaccination - impact on COVID-19. PLoS Pathog. 2021 Oct 25;17(10):e1009928. 

Merk D, Ptok J, Jakobs P, von Ameln F, Greulich J, Kluge P, Semperowitsch K, Eckermann O, Schaal H, Ale-Agha N, Altschmied J, Haendeler J. Selenoprotein T Protects Endothelial Cells against Lipopolysaccharide-Induced Activation and Apoptosis. Antioxidants (Basel). 2021 Sep 7;10(9):1427. 

Joachim A, Dewald F, Suárez I, Zemlin M, Lang I, Stutz R, Marthaler A, Bosse HM, Lübke N, Münch J, Bernard MA, Jeltsch K, Tönshoff B, Weidner N, Kräusslich HG, Birzele L, Hübner J, Schmied P, Meyer-Bühn M, Horemheb-Rubio G, Cornely OA, Haverkamp H, Wiesmüller G, Fätkenheuer G, Hero B, Kaiser R, Dötsch J, Rybniker J; B-FAST study group. Pooled RT-qPCR testing for SARS-CoV-2 surveillance in schools - a cluster randomised trial. EClinicalMedicine. 2021 Sep;39:101082.

Fischer JC, Schmidt AG, Bölke E, Uhrberg M, Keitel V, Feldt T, Jensen B, Häussinger D, Adams O, Schneider EM, Balz V, Enczmann J, Rox J, Hermsen D, Schulze-Bosse K, Kindgen-Milles D, Knoefel WT, van Griensven M, Haussmann J, Tamaskovics B, Plettenberg C, Scheckenbach K, Corradini S, Pedoto A, Maas K, Schmidt L, Grebe O, Esposito I, Ehrhardt A, Peiper M, Buhren BA, Calles C, Stöhr A, Lichtenberg A, Freise NF, Lutterbeck M, Rezazadeh A, Budach W, Matuschek C. Association of HLA genotypes, AB0 blood type and chemokine receptor 5 mutant CD195 with the clinical course of COVID-19. Eur J Med Res. 2021 Sep 16;26(1):107. 

Rudolph H, Gress K, Weiss C, Schroten H, Adams O, Tenenbaum T. General Characteristics of Children with Single- and Co-Infections and Febrile Seizures with a Main Focus on Respiratory Pathogens: Preliminary Results. Pathogens. 2021 Aug 20;10(8):1061. 

Kohns Vasconcelos M, Marazia C, Koniordou M, Fangerau H, Drexler I, Afum-Adjei Awuah A.  A conceptual approach to the rationale for SARS-CoV-2 vaccine allocation prioritisation. Pathog Glob Health. 2021 Jul;115(5):273-276. 

Jensen B, Luebke N, Feldt T, Keitel V, Brandenburger T, Kindgen-Milles D, Lutterbeck M, Freise NF, Schoeler D, Haas R, Dilthey A, Adams O, Walker A, Timm J, Luedde T.  Emergence of the E484K mutation in SARS-COV-2-infected immunocompromised patients treated with bamlanivimab in Germany.  Lancet Reg Health Eur. 2021 Sep;8:100164.

Smola A, Samazadeh S, Müller L, Adams O, Homey B, Albrecht P, Meller S. Omalizumab prevents anaphylactoid reactions to mRNA COVID-19 vaccine. J Eur Acad Dermatol Venereol. 2021 Nov;35(11):e743-e745.

Frenken P, Hartung HP, Olsson T, Adams O, Warnke C. Type O blood group associates with higher anti-JC polyomavirus antibody levels. Brain Behav. 2021 Aug;11(8):e2298. 

Cornberg M, Sandmann L, Protzer U, Niederau C, Tacke F, Berg T, Glebe D, Jilg W, Wedemeyer H, Wirth S, Höner Zu Siederdissen C, Lynen-Jansen P, van Leeuwen P, Petersen J; Collaborators (Timm J):  S3-Leitlinie der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS) zur Prophylaxe, Diagnostik und Therapie der Hepatitis-B-Virusinfektion – (AWMF-Register-Nr. 021-11). Z Gastroenterol. 2021 Jul;59(7):691-776.

Walker A, Houwaart T, Finzer P, Ehlkes L, Tyshaieva A, Damagnez M, Strelow D, Duplessis A, Nicolai J, Wienemann T, Tamayo T, Kohns Vasconcelos M, Hülse L, Hoffmann K, Lübke N, Hauka S, Andree M, Däumer MP, Thielen A, Kolbe-Busch S, Göbels K, Zotz R, Pfeffer K, Timm J, Dilthey AT; German COVID-19 OMICS Initiative (DeCOI). Characterization of SARS-CoV-2 infection clusters based on integrated genomic surveillance, outbreak analysis and contact tracing in an urban setting. Clin Infect Dis. 2021 Jun 28:ciab588.

Kitanovski S, Horemheb-Rubio G, Adams O, Gärtner B, Lengauer T, Hoffmann D, Kaiser R; Respiratory Virus Network. Rhinovirus prevalence as indicator for efficacy of measures against SARS-CoV-2. BMC Public Health. 2021 Jun 21;21(1):1178.

Kohns Vasconcelos M, Marazia C, Koniordou M, Fangerau H, Drexler I, Afum-Adjei Awuah A. A conceptual approach to the rationale for SARS-CoV-2 vaccine allocation prioritisation. Pathog Glob Health. 2021 Jul;115(5):273-276. 

Ptok J, Müller L, Ostermann PN, Ritchie A, Dilthey AT, Theiss S, Schaal H.Modifying splice site usage with ModCon: Maintaining the genetic code while changing the underlying mRNP code. Comput Struct Biotechnol J. 2021 May 21;19:3069-3076.

Moskorz W, Cosmovici C, Jäger PS, Cadeddu RP, Timm J, Haas R. Myelodysplastic syndrome patients display alterations in their immune status reflected by increased PD-L1-expressing stem cells and highly dynamic exhausted T-cell frequencies. Br J Haematol. 2021 Jun;193(5):941-945. 

Duwe SC, Schmidt B, Gärtner BC, Timm J, Adams O, Fickenscher H, Schmidtke M. Prophylaxis and treatment of influenza: options, antiviral susceptibility, and existing recommendations. GMS Infect Dis. 2021 Apr 30;9:Doc02. 

Ostermann PN, Ritchie A, Ptok J, Schaal H. Let it go: HIV-1 cis-acting repressive sequences. J Virol. 2021 Jul 12;95(15):e0034221. 

Klindt C, Jensen BE, Brandenburger T, Feldt T, Killer A, Schimmöller L, Antoch G, Senff T, Hauka S, Timm J, Bahners BH, Seidl M, Esposito I, Luedde T, Bode JG, Keitel V. Secondary sclerosing cholangitis as a complication of severe COVID-19: A case report and review of the literature. Clin Case Rep. 2021 May 24;9(5):e04068.

Schmitz K, Cox J, Esser LM, Voss M, Sander K, Löffler A, Hillebrand F, Erkelenz S, Schaal H, Kähne T, Klinker S, Zhang T, Nagel-Steger L, Willbold D, Seggewiß S, Schlütermann D, Stork B, Grimmler M, Wesselborg S, Peter C. An essential role of the autophagy activating kinase ULK1 in snRNP biogenesis. Nucleic Acids Res. 2021 Jun 21;49(11):6437-6455. 

Möhn N, Wattjes MP, Adams O, Nay S, Tkachenko D, Salge F, Heine J, Pars K, Höglinger G, Respondek G, Stangel M, Skripuletz T, Jacobs R, Sühs KW. PD-1-inhibitor pembrolizumab for treatment of progressive multifocal leukoencephalopathy. Ther Adv Neurol Disord. 2021 Mar 9;14:1756286421993684.

Hopfner F, Möhn N, Eiz-Vesper B, Maecker-Kolhoff B, Gottlieb J, Blasczyk R, Mahmoudi N, Pars K, Adams O, Stangel M, Wattjes MP, Höglinger G, Skripuletz T. Allogeneic BK Virus-Specific T-Cell Treatment in 2 Patients With Progressive Multifocal Leukoencephalopathy. Neurol Neuroimmunol Neuroinflamm. 2021 May 17;8(4):e1020

Keitel V, Bode JG, Feldt T, Walker A, Müller L, Kunstein A, Klindt C, Killer A, Senff T, Timm J, Ostermann P, Damagnez M, Lübke N, Adams O, Schaal H, Antoch G, Neubert J, Albrecht P, Meuth S, Elben S, Mohring A, Fischer JC, Bölke E, Hoenig M, Schulz AS, Luedde T, Jensen B. Case Report: Convalescent Plasma Achieves SARS-CoV-2 Viral Clearance in a Patient With Persistently High Viral Replication Over 8 Weeks Due to Severe Combined Immunodeficiency (SCID) and Graft Failure. Front Immunol. 2021 May 3;12:645989.

Keitel V, Jensen B, Feldt T, Fischer JC, Bode JG, Matuschek C, Bölke E, Budach W, Plettenberg C, Scheckenbach K, Kindgen-Milles D, Timm J, Müller L, Kolbe H, Stöhr A, Calles C, Hippe A, Verde P, Spinner CD, Schneider J, Wolf T, Kern WV, Nattermann J, Zoufaly A, Ohmann C, Luedde T; RES-Q-HR Trial Team. Reconvalescent plasma/camostat mesylate in early SARS-CoV-2 Q-PCR positive high-risk individuals (RES-Q-HR): a structured summary of a study protocol for a randomized controlled trial. Trials. 2021 May 17;22(1):343.

Gliga S, Orth HM, Lübke N, Timm J, Luedde T, Jensen BO.  Multicentric Castleman's disease in HIV patients: a single-center cohort diagnosed from 2008 to 2018. Infection. 2021 Oct;49(5):945-951.

Müller L, Andrée M, Moskorz W, Drexler I, Walotka L, Grothmann R, Ptok J, Hillebrandt J, Ritchie A, Rabl D, Ostermann PN, Robitzsch R, Hauka S, Walker A, Menne C, Grutza R, Timm J, Adams O, Schaal H. Age-dependent immune response to the Biontech/Pfizer BNT162b2 COVID-19 vaccination. Clin Infect Dis. 2021 Dec 6;73(11):2065-2072. 

Liu J, Yang X, Wang H, Li Z, Deng H, Liu J, Xiong S, He J, Feng X, Guo C, Wang W, Zelinskyy G, Trilling M, Sutter K, Senff T, Menne C, Timm J, Zhang Y, Deng F, Lu Y, Wu J, Lu M, Yang D, Dittmer U, Wang B, Zheng X.  Analysis of the Long-Term Impact on Cellular Immunity in COVID-19-Recovered Individuals Reveals a Profound NKT Cell Impairment.  mBio. 2021 Apr 27;12(2):e00085-21.

Werner J, Kronberg RM, Stachura P, Ostermann PN, Müller L, Schaal H, Bhatia S, Kather JN, Borkhardt A, Pandyra AA, Lang KS, Lang PA. Deep Transfer Learning Approach for Automatic Recognition of Drug Toxicity and Inhibition of SARS-CoV-2. Viruses. 2021 Apr 2;13(4):610. 

Xu HC, Wang R, Shinde PV, Walotka L, Huang A, Poschmann G, Huang J, Liu W, Stühler K, Schaal H, Bergthaler A, Pandyra AA, Hardt C, Lang KS, Lang PA.  Slow viral propagation during initial phase of infection leads to viral persistence in mice. Commun Biol. 2021 Apr 29;4(1):508.

Kindgen-Milles D, Brandenburger T, Braun JFW, Cleff C, Moussazadeh K, Mrosewski I, Timm J, Wetzchewald D. Prevalence of SARS-COV-2 positivity in 516 German intensive care and emergency physicians studied by seroprevalence of antibodies National Covid Survey Germany (NAT-COV-SURV). PLoS One. 2021 Apr 8;16(4):e0248813.

Müller L, Ostermann PN, Walker A, Wienemann T, Mertens A, Adams O, Andree M, Hauka S, Lübke N, Keitel V, Drexler I, Di Cristanziano V, Hermsen DF, Kaiser R, Boege F, Klein F, Schaal H, Timm J, Senff T. Sensitivity of anti-SARS-CoV-2 serological assays in a high-prevalence setting. Eur J Clin Microbiol Infect Dis. 2021 May;40(5):1063-1071.

Schmidt L, Jensen BO, Walker A, Keitel-Anselmino V, di Cristanziano V, Böhm M, Knops E, Heger E, Kaiser R, de Luca A, Oette M, Häussinger D, Timm J, Fuchs A, Lübke N.  Torque Teno Virus plasma level as novel biomarker of retained immunocompetence in HIV-infected patients. Infection. 2021 Jun;49(3):501-509.

Zimmermann R, Külper-Schiek W, Steffen G, Gillesberg Lassen S, Bremer V, Dudareva S; die Hepatitis-Monitoring-Arbeitsgruppe. How to assess the elimination of viral hepatitis B, C, and D in Germany? Outcomes of an interdisciplinary workshop]. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2021 Jan;64(1):77-90.

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