Publikationen

2024:

Neuwahl J, Neumann CA, Fitz AC, Biermann AD, Magel M, Friedrich A, Sellin L, Stork B, Piekorz RP, Proksch P, Budach W, Jänicke RU, Sohn D. Combined inhibition of class 1-PI3K-alpha and delta isoforms causes senolysis by inducing p21(WAF1/CIP1) proteasomal degradation in senescent cells. Cell Death Dis. 2024 May 29;15(5):373. doi: 10.1038/s41419-024-06755-x.

2022:

Yassine M, Hassan SA, Sommer S, Yücel LA, Bellert H, Hallenberger J, Sohn D, Korf HW, von Gall C, Ali AAH. Radiotherapy of the Hepatocellular Carcinoma in Mice Has a Time-Of-Day-Dependent Impact on the Mouse Hippocampus. Cells. 2022 Dec 23;12(1):61. doi: 10.3390/cells12010061.

2021:

Hassan SA, Ali AAH, Sohn D, Flögel U, Jänicke RU, Korf HW, von Gall C. Does timing matter in radiotherapy of hepatocellular carcinoma? An experimental study in mice. Cancer Med. 2021 Nov;10(21):7712-7725. doi: 10.1002/cam4.4277. Epub 2021 Sep 20.

2020:

Hassan SA, Ali AAH, Yassine M, Sohn D, Pfeffer M, Jänicke RU, Korf HW, von Gall C. Relationship between locomotor activity rhythm and corticosterone levels during HCC development, progression, and treatment in a mouse model. J Pineal Res. 2021 Apr;70(3):e12724. doi: 10.1111/jpi.12724. Epub 2021 Mar 5.

Bergmann L, Lang A, Bross C, Altinoluk-Hambüchen S, Fey I, Overbeck N, Stefanski A, Wiek C, Kefalas A, Verhülsdonk P, Mielke C, Sohn D, Stühler K, Hanenberg H, Jänicke RU, Scheller J, Reichert AS, Ahmadian MR, Piekorz RP. Subcellular Localization and Mitotic Interactome Analyses Identify SIRT4 as a Centrosomally Localized and Microtubule Associated Protein. Cells. 2020 Aug 24;9(9):1950. doi: 10.3390/cells9091950.

Hüsemann LC, Reese A, Radine C, Piekorz RP, Budach W, Sohn D, Jänicke RU. The microtubule targeting agents eribulin and paclitaxel activate similar signaling pathways and induce cell death predominantly in a caspase-independent manner. Cell Cycle. 2020 Feb;19(4):464-478. doi: 10.1080/15384101.2020.1716144. Epub 2020 Jan 20.

2019:

Radine C, Peters D, Reese A, Neuwahl J, Budach W, Jänicke RU, Sohn D. The RNA-binding protein RBM47 is a novel regulator of cell fate decisions by transcriptionally regulating the p53-p21-axis. Cell Death Differ. 2019. doi:10.1038/s41418-019-0414-6.

2018:

Ingenhag D, Reister S, Auer F, Bhatia S, Wildenhain S, Picard D, Remke M, Hoell JI, Kloetgen A, Sohn D, Jänicke RU, Koegler G, Borkhardt A, Hauer J. The homeobox transcription factor HB9 induces senescence and blocks differentiation in hematopoietic stem and progenitor cells. Haematologica. 2019 Jan;104(1):35-46. doi: 10.3324/haematol.2018.189407. Epub 2018 Aug 9.

2017:

Peters D, Radine C, Reese A, Budach W, Sohn D, Jänicke RU. The DEAD-Box RNA helicase DDX41 is a novel repressor of p21(WAF1/CIP1) mRNA translation. J Biol Chem. 2017 Mar 27; pii: jbc.M116.772327. doi: 10.1074/jbc.M116.772327. [Epub ahead of print]

Brandt A, Meeßen J, Jänicke RU, Raguse M, Ott S. Simulated Space Radiation: Impact of Four Different Types of High-Dose Ionizing Radiation on the Lichen Xanthoria elegans. Astrobiology 2017 Feb;17(2):136-144. doi: 10.1089/ast.2015.1455.

2016:

Sohn D, Peters D, Piekorz RP, Budach W, Jänicke RU. miR-30e controls DNA damage-induced stress responses by modulating expression of the CDK inhibitor p21WAF1/CIP1 and caspase-3. Oncotarget. 2016 Feb 17; doi: 10.18632/oncotarget.7432. [Epub ahead of print].

Gerber PA, Buhren BA, Schrumpf H, Hevezi P, Bölke E, Sohn D, Jänicke RU, Belum VR, Robert C, Lacouture ME, Homey B. . Mechanisms of skin aging induced by EGFR inhibitors. Support Care Cancer. 2016. doi: 10.1007/s00520-016-3254-7

2013:

Neise D, Sohn D, Stefanski A, Goto H, Inagaki M, Wesselborg S, Budach W, Stühler K, Jänicke RU.The p90 ribosomal S6 kinase (RSK) inhibitor BI-D1870 prevents gamma irradiation-induced apoptosis and mediates senescence via RSK- and p53-independent accumulation of p21WAF1/CIP1. Cell Death Dis. 2013 Oct 17;4:e859. doi: 10.1038/cddis.2013.386.

Pietkiewicz S, Sohn D, Piekorz RP, Grether-Beck S, Budach W, Sabapathy K, Jänicke RU. Oppositional regulation of Noxa by JNK1 and JNK2 during apoptosis induced by proteasomal inhibitors. PLoS One. 2013 Apr 11;8(4):e61438. doi: 10.1371/journal.pone.0061438. Print 2013.

Milojkovic A, Hemmati PG, Müer A, Overkamp T, Chumduri C, Jänicke RU, Gillissen B, Daniel PT. p14ARF induces apoptosis via an entirely caspase-3-dependent mitochondrial amplification loop. Int J Cancer. 2013 Dec 1;133(11):2551-62. doi: 10.1002/ijc.28279. Epub 2013 Aug 1.

2011:

Sohn D, Budach W, Jänicke RU. Caspase-2 is required for DNA damage-induced expression of the CDK inhibitor p21(WAF1/CIP1). Cell Death Differ. 2011 Oct;18(10):1664-74. doi: 10.1038/cdd.2011.34. Epub 2011 Apr 8.

Berg E, Christensen MO, Dalla Rosa I, Wannagat E, Jänicke RU, Rösner LM, Dirks WG, Boege F, Mielke C. XRCC4 controls nuclear import and distribution of Ligase IV and exchanges faster at damaged DNA in complex with Ligase IV. DNA Repair (Amst). 2011 Dec 10;10(12):1232-42. doi: 10.1016/j.dnarep.2011.09.012. Epub 2011 Oct 5.

Zhang Y, Johansson E, Miller ML, Jänicke RU, Ferguson DJ, Plas D, Meller J, Anderson MW. Identification of a conserved anti-apoptotic protein that modulates the mitochondrial apoptosis pathway. PLoS One. 2011;6(9):e25284. doi: 10.1371/journal.pone.0025284. Epub 2011 Sep 30.

Riffell JL, Jänicke RU, Roberge M. Caspase-3-dependent mitotic checkpoint inactivation by the small-molecule inducers of mitotic slippage SU6656 and geraldol. Mol Cancer Ther. 2011 May;10(5):839-49. doi: 10.1158/1535-7163.MCT-10-0909. Epub 2011 Mar 25.

Riediger F, Quack I, Qadri F, Hartleben B, Park JK, Potthoff SA, Sohn D, Sihn G, Rousselle A, Fokuhl V, Maschke U, Purfürst B, Schneider W, Rump LC, Luft FC, Dechend R, Bader M, Huber TB, Nguyen G, Muller DN. Prorenin receptor is essential for podocyte autophagy and survival. J Am Soc Nephrol. 2011 Dec;22(12):2193-202. doi: 10.1681/ASN.2011020200. Epub 2011 Oct 27.

2010:

Neise D, Sohn D, Budach W, Jänicke RU. Evidence for a differential modulation of p53-phosphorylating kinases by the cyclin-dependent kinase inhibitor p21WAF1/CIP1. Cell Cycle. 2010 Sep 1;9(17):3575-83. Epub 2010 Sep 25.

Schmidt S, Essmann F, Cirstea IC, Kuck F, Thakur HC, Singh M, Kletke A, Jänicke RU, Wiek C, Hanenberg H, Ahmadian MR, Schulze-Osthoff K, Nürnberg B, Piekorz RP. The centrosome and mitotic spindle apparatus in cancer and senescence. Cell Cycle. 2010 Nov 15;9(22):4469-73.

Schmidt S, Schneider L, Essmann F, Cirstea IC, Kuck F, Kletke A, Jänicke RU, Wiek C, Hanenberg H, Ahmadian MR, Schulze-Osthoff K, Nürnberg B, Piekorz RP. The centrosomal protein TACC3 controls paclitaxel sensitivity by modulating a premature senescence program. Oncogene. 2010 Nov 18;29(46):6184-92. doi: 10.1038/onc.2010.354. Epub 2010 Aug 23.

2009:

Sohn D, Graupner V, Neise D, Essmann F, Schulze-Osthoff K, Jänicke RU. Pifithrin-alpha protects against DNA damage-induced apoptosis downstream of mitochondria independent of p53. Cell Death Differ. 2009 Jun;16(6):869-78. doi: 10.1038/cdd.2009.17. Epub 2009 Feb 20.

Jänicke RU, Graupner V, Budach W, Essmann F. The do's and don'ts of p53 isoforms. Biol Chem. 2009 Oct;390(10):951-63. doi: 10.1515/BC.2009.093.

Twarock S, Röck K, Sarbia M, Weber AA, Jänicke RU, Fischer JW. Synthesis of hyaluronan in oesophageal cancer cells is uncoupled from the prostaglandin-cAMP pathway. Br J Pharmacol. 2009 May;157(2):234-43. doi: 10.1111/j.1476-5381.2009.00138.x. Epub 2009 Mar 26.

Graupner V, Schulze-Osthoff K, Essmann F, Jänicke RU. Functional characterization of p53beta and p53gamma, two isoforms of the tumor suppressor p53. Cell Cycle. 2009 Apr 15;8(8):1238-48. Epub 2009 Apr 23.

Jänicke RU. MCF-7 breast carcinoma cells do not express caspase-3. Breast Cancer Res Treat. 2009 Sep;117(1):219-21. doi: 10.1007/s10549-008-0217-9. Epub 2008 Oct 14.

2008:

Jänicke RU, Sohn D, Schulze-Osthoff K. The dark side of a tumor suppressor: anti-apoptotic p53. Cell Death Differ. 2008 Jun;15(6):959-76. doi: 10.1038/cdd.2008.33. Epub 2008 Mar 2

Neise D, Graupner V, Gillissen BF, Daniel PT, Schulze-Osthoff K, Jänicke RU, Essmann F. Activation of the mitochondrial death pathway is commonly mediated by a preferential engagement of Bak. Oncogene. 2008 Feb 28;27(10):1387-96. Epub 2007 Sep 3.

2007:

Jänicke RU, Sohn D, Essmann F, Schulze-Osthoff K. The multiple battles fought by anti-apoptotic p21. Cell Cycle. 2007 Feb 15;6(4):407-13. Epub 2007 Feb 19.

Samraj AK, Sohn D, Schulze-Osthoff K, Schmitz I. Loss of caspase-9 reveals its essential role for caspase-2 activation and mitochondrial membrane depolarization. Mol Biol Cell. 2007 Jan;18(1):84-93. Epub 2006 Nov 1.

Janssen K, Pohlmann S, Jänicke RU, Schulze-Osthoff K, Fischer U. Apaf-1 and caspase-9 deficiency prevents apoptosis in a Bax-controlled pathway and promotes clonogenic survival during paclitaxel treatment. Blood. 2007 Nov 15;110(10):3662-72. Epub 2007 Jul 25.

2006:

Sohn D, Essmann F, Schulze-Osthoff K, Jänicke RU. p21 blocks irradiation-induced apoptosis downstream of mitochondria by inhibition of cyclin-dependent kinase-mediated caspase-9 activation. Cancer Res. 2006 Dec 1;66(23):11254-62.

Jänicke RU, Sohn D, Totzke G, Schulze-Osthoff K. Caspase-10 in mouse or not? Science. 2006 Jun 30;312(5782):1874.

Sohn D, Totzke G, Schulze-Osthoff K, Jänicke RU. Friend or foe? The proteasome in combined cancer therapy. Cell Cycle. 2006 Apr;5(8):841-5. Epub 2006 Apr 17.

Sohn D, Totzke G, Essmann F, Schulze-Osthoff K, Levkau B, Jänicke RU. The proteasome is required for rapid initiation of death receptor-induced apoptosis. Mol Cell Biol. 2006 Mar;26(5):1967-78.

Tenenbaum T, Essmann F, Adam R, Seibt A, Jänicke RU, Novotny GE, Galla HJ, Schroten H. Cell death, caspase activation, and HMGB1 release of porcine choroid plexus epithelial cells during Streptococcus suis infection in vitro. Brain Res. 2006 Jul 19;1100(1):1-12. Epub 2006 Jun 15.

Totzke G, Essmann F, Pohlmann S, Lindenblatt C, Jänicke RU, Schulze-Osthoff K. A novel member of the IkappaB family, human IkappaB-zeta, inhibits transactivation of p65 and its DNA binding. J Biol Chem. 2006 May 5;281(18):12645-54. Epub 2006 Mar 2.

2005:

Sohn D, Schulze-Osthoff K, Jänicke RU. Caspase-8 can be activated by interchain proteolysis without receptor-triggered dimerization during drug-induced apoptosis. J Biol Chem. 2005 Feb 18;280(7):5267-73. Epub 2004 Dec 15.

Essmann F, Pohlmann S, Gillissen B, Daniel PT, Schulze-Osthoff K, Jänicke RU. Irradiation-induced translocation of p53 to mitochondria in the absence of apoptosis. J Biol Chem. 2005 Nov 4;280(44):37169-77. Epub 2005 Sep 7.

Engels IH, Totzke G, Fischer U, Schulze-Osthoff K, Jänicke RU. Caspase-10 sensitizes breast carcinoma cells to TRAIL-induced but not tumor necrosis factor-induced apoptosis in a caspase-3-dependent manner. Mol Cell Biol. 2005 Apr;25(7):2808-18.

2004:

Essmann F, Engels IH, Totzke G, Schulze-Osthoff K, Jänicke RU. Apoptosis resistance of MCF-7 breast carcinoma cells to ionizing radiation is independent of p53 and cell cycle control but caused by the lack of caspase-3 and a caffeine-inhibitable event. Cancer Res. 2004 Oct 1;64(19):7065-72.

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