2019

 

iRhom2 inhibits bile duct obstruction-induced liver fibrosis.
Sundaram B, Behnke K, Belancic A, Al-Salihi MA, Thabet Y, Polz R, Pellegrino R, Zhuang Y, Shinde PV, Xu HC, Vasilevska J, Longerich T, Herebian D, Mayatepek E, Bock HH, May P, Kordes C, Aghaeepour N, Mak TW, Keitel V, Häussinger D, Scheller J, Pandyra AA, Lang KS, Lang PA.
Sci Signal. 2019 Oct 29;12(605). pii: eaax1194. doi: 10.1126/scisignal.aax1194.

Abstract

 

A Novel Role for IL-6 Receptor Classic Signaling: Induction of RORγt+Foxp3+ Tregs with Enhanced Suppressive Capacity.
Hagenstein J, Melderis S, Nosko A, Warkotsch MT, Richter JV, Ramcke T,
Herrnstadt GR, Scheller J, Yan I, Mittrücker HW, Kluger MA, Steinmetz OM.
J Am Soc Nephrol. 2019 Jul 16. pii: ASN.2019020118. doi: 10.1681/ASN.2019020118. [Epub ahead of print]

Abstract

 

Doreen M.Floss, Jürgen Scheller
Naturally occurring and synthetic constitutive-active cytokine receptors in disease and therapy.
Cytokine and Growth Factor Reviewsdoi. 10.1016/j.cytogfr.2019.05.007

Abstract



2018


Engelowski E, Modares NF, Gorressen S, Bouvain P, Semmler D,
Alter C, Ding Z, Flögel U, Schrader J, Xu H, Lang PA, Fischer J, Floss DM, Scheller J.
IL-23R Signaling Plays No Role in Myocardial Infarction.
Sci Rep. 2018 Nov 20;8(1):17078. doi: 10.1038/s41598-018-35188-8.

Abstract



Temme S, Baran P, Bouvain P, Grapentin C, Krämer W, Knebel B, Al-Hasani H, Moll JM, Floss D, Schrader J,Schubert R, Flögel U, Scheller J.
Synthetic Cargo Internalization Receptor System for Nanoparticle Tracking of Individual Cell Populations by Fluorine Magnetic Resonance Imaging.
ACS Nano. 2018 Nov 5. doi: 10.1021/acsnano.8b05698. [Epub ahead of print]

Abstract

Haghighi F, Dahlmann J, Nakhaei-Rad S, Lang A, Kutschka I, Zenker M, Kensah G, Piekorz RP, Ahmadian MR.
bFGF-mediated pluripotency maintenance in human induced pluripotent stem cells is associated with NRAS-MAPK signaling.
Cell Commun Signal. 2018 Dec 5;16(1):96. doi: 10.1186/s12964-018-0307-1.


Abstract

Rezaei Adariani S, Buchholzer M, Akbarzadeh M, Nakhaei-Rad S, Dvorsky R, Ahmadian MR.
Structural snapshots of RAF kinase interactions.
Biochem Soc Trans. 2018 Dec 17;46(6):1393-1406. doi: 10.1042/BST20170528. Epub 2018 Oct 31. Review.


Abstract


Hain A, Krämer M, Linka RM, Nakhaei-Rad S, Ahmadian MR, Häussinger D, Borkhardt A, Münk C.
IL-2 Inducible Kinase ITK is Critical for HIV-1 Infection of Jurkat T-cells.
Sci Rep. 2018 Feb 16;8(1):3217. doi: 10.1038/s41598-018-21344-7.


Abstract

Madhurendra Singh, Laura Bergmann, Alexander Lang, Katja Pexa, Fabian Kuck, Dennis Stibane, Linda Janke, Hakima Ezzahoini, Antje Lindecke,
Constanze Wiek, Helmut Hanenberg, Karl Köhrer, Charlotte von Gall, Hans Reinke, and Roland P. Piekorz
Gαi3 signaling is associated with sexual dimorphic expression of the clock-controlled output gene Dbp in murine liver
Oncotarget. 2018; 9:30213-30224.


Abstract

Nakhaei-Rad S, Haghighi F, Nouri P, Rezaei Adariani S, Lissy J, Kazemein Jasemi NS, Dvorsky R,*Ahmadian MR*.Structural fingerprints, interactions, and signaling networks of RAS family proteins beyond RAS isoforms.Crit Rev Biochem Mol Biol. 2018 Apr;53(2):130-156. doi: 10.1080/10409238.2018.1431605. Epub 2018 Feb 19. Review. No abstract available.


Abstract

Engelowski E, Schneider A, Franke M, Xu H, Clemen R, Lang A, Baran P, Binsch C,
Knebel B, Al-Hasani H,4, Moll JM1, Floß DM, Lang PA, Scheller J.
Synthetic cytokine receptors transmit biological signals using artificial ligands.
Nat Commun. 2018 May 23;9(1):2034. doi: 10.1038/s41467-018-04454-8.


Abstract



Beer-Hammer S, Lee SC, Mauriac SA, Leiss V, Groh IAM, Novakovic A, Piekorz RP, Bucher K, Chen C,
Ni K, Singer W, Harasztosi C, Schimmang T, Zimmermann U, Pfeffer K, Birnbaumer L, Forge A, Montcouquiol M, Knipper M, Nürnberg B, Rüttiger L (2018).
Gαi proteins are indispensable for hearing. Cellular Physiology and Biochemistry, in press.


Abstract


Lamertz L, Floss DM, Scheller J.
Combined deletion of the fibronectin-type III domains and the stalk region results in ligand-independent, constitutive activation of the Interleukin 6 signal-transducing receptor gp130.
Cytokine. 2018 May 19. pii: S1043-4666(18)30210-2. doi: 10.1016/j.cyto.2018.05.011. [Epub ahead of print]


Abstract



Baran P, Hansen S, Waetzig GH, Akbarzadeh M, Lamertz L, Huber HJ, Ahmadian MR,
Moll JM, Scheller J.
The balance of interleukin (IL)-6, IL-6·soluble IL-6 receptor (sIL-6R), and IL-6·sIL-6R·sgp130 complexes allows simultaneous classic and trans-signaling.
J Biol Chem. 2018 May 4;293(18):6762-6775. doi: 10.1074/jbc.RA117.001163.
Epub 2018 Mar 20.


Abstract



Behnke K, Zhuang Y, Xu HC, Sundaram B, Reich M, Shinde PV, Huang J, Modares NF,
Tumanov AV, Polz R, Scheller J, Ware CF, Pfeffer K, Keitel V, Häussinger D, Pandyra AA, Lang KS, Lang PA.
B cell-mediated maintenance of CD169+ cells is critical for liver regeneration.
Hepatology. 2018 May 9. doi: 10.1002/hep.30088. [Epub ahead of print]


Abstract
 

Alexander Lang and Roland P. Piekorz
Novel role of the SIRT4-OPA1 axis in mitochondrial quality control.
Cell Stress,Vol.2,No.1,pp.1-3; DOI:10.15698/cst2018.01.118 .


Abstract



Martinelli S, Krumbach OHF, Pantaleoni F, Coppola S, Amin E, Pannone L, Nouri K, Farina L, Dvorsky R, Lepri F, Buchholzer M, Konopatzki R, Walsh L, Payne K, Pierpont ME, Vergano SS, Langley KG, Larsen D, Farwell KD, Tang S, Mroske C, Gallotta I, Di Schiavi E, Della Monica M, Lugli L, Rossi C, Seri M, Cocchi G, Henderson L, Baskin B, Alders M, Mendoza-Londono R, Dupuis L, Nickerson DA, Chong JX; University of Washington Center for Mendelian Genomics, Meeks N, Brown K, Causey T, Cho MT, Demuth S, Digilio MC, Gelb BD, Bamshad MJ, Zenker M, Ahmadian MR, Hennekam RC, Tartaglia M, Mirzaa GM.
Functional Dysregulation of CDC42 Causes Diverse Developmental Phenotypes.
Am J Hum Genet. 2018 Feb 1;102(2):309-320. doi: 10.1016/j.ajhg.2017.12.015. Epub 2018 Jan 25.


Abstract




2017


Floss DM, Schönberg M, Franke M, Horstmeier FC, Engelowski E, Schneider A, Rosenfeldt EM, Scheller J.
IL-6/IL-12 Cytokine Receptor Shuffling of Extra- and Intracellular Reveals Canonical STAT Activation via Synthetic IL-35 and IL-39 Signaling.
Sci Rep. 2017 Nov 9;7(1):15172. doi: 10.1038/s41598-017-15173-3.

Abstract

Moll JM, Wehmöller M, Frank NC, Homey L, Baran P, Garbers C, Lamertz L, Axelrod JH, Galun E,  Mootz HD, Scheller J.
Split2 Protein-Ligation Generates Active IL-6-Type Hyper-Cytokines from Inactive Precursors.
ACS Synth Biol. 2017 Nov 29. doi: 10.1021/acssynbio.7b00208. [Epub ahead of print]

Abstract

Schmok E, Abad Dar M, Behrends J, Erdmann H, Rückerl D, Endermann T,
Heitmann L, Hessmann M, Yoshimura A, Rose-John S, Scheller J, Schaible UE, Ehlers S,
Lang R, Hölscher C.
Suppressor of Cytokine Signaling 3 in Macrophages Prevents Exacerbated Interleukin-6-Dependen
t Arginase-1 Activity and Early Permissiveness to Experimental Tuberculosis.
Front Immunol. 2017 Nov 10;8:1537. doi: 10.3389/fimmu.2017.01537. eCollection 2017.

Abstract
 
Lang A, Anand R, Altinoluk-Hambüchen S, Ezzahoini H, Stefanski A, Iram A, Bergmann L,
Urbach J, Böhler P, Hänsel J, Franke M, Stühler K, Krutmann J, Scheller J, Stork B, Reichert AS, Piekorz RP.
SIRT4 interacts with OPA1 and regulates mitochondrial quality control and mitophagy.
Aging (Albany NY). 2017 Oct 29;9(10):2163-2189. doi: 10.18632/aging.101307.
 
Abstract

Bucher K, Schmitt F, Mothes B, Blumendeller C, Schäll D, Piekorz R, Hirsch E, Nürnberg B, Beer-Hammer S.
Deficiency of PI3-Kinase catalytic isoforms p110γ and p110δ in mice enhances the IL-17/G-CSF axis and induces neutrophilia.
Cell Commun Signal. 2017 Jul 19;15(1):28. doi: 10.1186/s12964-017-0185-y.

Abstract

Arnold P, Boll I, Rothaug M, Schumacher N, Schmidt F, Wichert R, Schneppenheim J, Lokau J, Pickhinke U, Koudelka T, Tholey A, Rabe B, Scheller J, Lucius R, Garbers C,
Rose-John S, Becker-Pauly C.
Meprin Metalloproteases Generate Biologically Active Soluble Interleukin-6 Receptor to Induce Trans-Signaling.
Sci Rep. 2017 Mar 9;7:44053. doi: 10.1038/srep44053.

Abstract

Hummel TM, Ackfeld T, Schönberg M, Ciupka G, Schulz F, Oberdoerster A, Grötzinger J, Scheller J, Floss DM.
Synthetic Deletion of the Interleukin 23 Receptor (IL-23R) Stalk Region Led to Autonomous IL-23R Homodimerization
and Activation.
Mol Cell Biol. 2017 Aug 11;37(17). pii: e00014-17. doi: 10.1128/MCB.00014-17. Print 2017 Sep 1.

Abstract

Ziegler V, Henninger C, Simiantonakis I, Buchholzer M, Ahmadian MR, Budach W, Fritz G.
Rho inhibition by lovastatin affects apoptosis and DSB repair of primary human lung cells in vitro and lung tissue in vivo following fractionated irradiation.
Cell Death Dis. 2017 Aug 10;8(8):e2978. doi: 10.1038/cddis.2017.372.

Abstract

Altmüller F, Pothula S, Annamneedi A, Nakhaei-Rad S, Montenegro-Venegas C, Pina-Fernández E, Marini C, Santos M, Schanze D, Montag D, Ahmadian MR, Stork O, Zenker M, Fejtova A.
Aberrant neuronal activity-induced signaling and gene expression in a mouse model of RASopathy.
PLoS Genet. 2017 Mar 27;13(3):e1006684. doi: 10.1371/journal.pgen.1006684. eCollection 2017 Mar.

Abstract

Pantaleoni F, Lev D, Cirstea IC, Motta M, Lepri FR, Bottero L, Cecchetti S, Linger I, Paolacci S, Flex E, Novelli A, Carè A, Ahmadian MR,
Aberrant HRAS transcript processing underlies a distinctive phenotype within the RASopathy clinical spectrum.
Stellacci E, Tartaglia M.
Hum Mutat. 2017 Jul;38(7):798-804. doi: 10.1002/humu.23224. Epub 2017 May 3.

Abstract

Altmüller F, Lissewski C, Bertola D, Flex E, Stark Z, Spranger S, Baynam G,
Buscarilli M, Dyack S, Gillis J, Yntema HG, Pantaleoni F, van Loon RL, MacKay S, Mina K, Schanze I, Tan TY,
Walsh M, White SM, Niewisch MR, García-Miñaúr S, Plaza D, Ahmadian MR, Cavé H, Tartaglia M, Zenker M.
Genotype and phenotype spectrum of NRAS germline variants.
Eur J Hum Genet. 2017 Jun;25(7):823-831. doi: 10.1038/ejhg.2017.65. Epub 2017 May 3.

Abstract

Nouri K, Timson DJ, Ahmadian MR.
New model for the interaction of IQGAP1 with CDC42 and RAC1.
Small GTPases. 2017 Jun 16:1-7. doi: 10.1080/21541248.2017.1321169. [Epub ahead of print]

Abstract

Hesse J, Leberling S, Boden E, Friebe D, Schmidt T, Ding Z, Dieterich P, Deussen A, Roderigo C, Rose CR, Floss DM, Scheller J, Schrader J. FASEB J.
CD73-derived adenosine and tenascin-C control cytokine production by epicardium-derived cells formed after myocardial infarction. 2017 Mar 31. pii: fj.201601307R. doi: 10.1096/fj.201601307R.. PMID: 28363952 [PubMed - as supplied by publisher]

Abstract


2016

 

Kötter S, Kazmierowska M, Andresen C, Bottermann K, Grandoch M, Gorressen S, Heinen A, Moll JM, Scheller J, Gödecke A,
Fischer JW, Schmitt JP, Krüger M.
Titin-Based Cardiac Myocyte Stiffening Contributes to Early Adaptive Ventricular Remodeling After Myocardial Infarction.
Circ Res. 2016 Oct 14;119(9):1017-1029. Epub 2016 Sep 20.

Nakhaeizadeh H, Amin E, Nakhaei-Rad S, Dvorsky R, Ahmadian MR.
The RAS-Effector Interface: Isoform-Specific Differences in the Effector Binding Regions.
PLoS One. 2016 Dec 9;11(12):e0167145. doi: 10.1371/journal.pone.0167145.

Nouri K, Fansa EK, Amin E, Dvorsky R, Gremer L, Willbold D, Schmitt L, Timson DJ, Ahmadian MR.
QGAP1 Interaction with RHO Family Proteins Revisited: KINETIC AND EQUILIBRIUM EVIDENCE FOR MULTIPLE DISTINCT BINDING SITES.
J Biol Chem. 2016 Dec 16;291(51):26364-26376.

Aden K, Breuer A, Rehman A, Geese H, Tran F, Sommer J, Waetzig GH, Reinheimer TM, Schreiber S, Rose-John S, Scheller J, Rosenstiel P
Classic IL-6R signalling is dispensable for intestinal epithelial proliferation and repair.
Oncogenesis. 2016 Nov 21;5(11):e270. doi: 10.1038/oncsis.2016.71.

Amin E, Jaiswal M, Derewenda U, Reis K, Nouri K, Koessmeier KT, Aspenström P, Somlyo AV, Dvorsky R, Ahmadian MR.
Deciphering the Molecular and Functional Basis of RHOGAP Family Proteins: A SYSTEMATIC APPROACH TOWARD SELECTIVE INACTIVATION OF RHO FAMILY PROTEINS.
J Biol Chem. 2016 Sep 23;291(39):20353-71. doi: 10.1074/jbc.M116.736967.

Nouri K, Fansa EK, Amin E, Dvorsky R, Gremer L, Willbold D, Schmitt L, Timson DJ, Ahmadian MR.
IQGAP1 interaction with RHO family proteins revisited: Kinetic and equilibrium evidence for multiple distinct binding sites.
J Biol Chem. 2016 Nov 4. pii: jbc.M116.752121. [Epub ahead of print]

Boppudi S, Bögershausen N, Hove HB, Percin EF, Aslan D, Dvorsky R, Kayhan G, Li Y, Cursiefen C, Tantcheva-Poor I, Toft PB, Bartsch O, Lissewski C, Wieland I, Jakubiczka S, Wollnik B, Ahmadian MR, Heindl LM, Zenker M
Specific mosaic KRAS mutations affecting codon 146 cause oculoectodermal syndrome and encephalocraniocutaneous lipomatosis.
Clin Genet. 2016 Oct;90(4):334-42. doi: 10.1111/cge.12775.

Galectin-1 dimers can scaffold Raf-effectors to increase H-ras nanoclustering.
Blazeevitse O, Mideksa YG, Šolman M, Ligabue A, Ariotti N, Nakhaeizadeh H, Fansa EK, Papageorgiou AC, Wittinghofer A, Ahmadian MR, Abankwa D.
Galectin-1 dimers can scaffold Raf-effectors to increase H-ras nanoclustering.
Sci Rep. 2016 Apr 18;6:24165. doi: 10.1038/srep24165.

Becker MS, Müller PM, Bajorat J, Schroeder A, Giaisi M, Amin E, Ahmadian MR, Rocks O, Köhler R, Krammer PH, Li-Weber M.
The anticancer phytochemical rocaglamide inhibits Rho GTPase activity and cancer cell migration.
Oncotarget. 2016 Jun 20. doi: 10.18632/oncotarget.10188. [Epub ahead of print]

Monhasery N, Moll J, Cuman C, Franke M, Lamertz L, Nitz R, Görg B, Häussinger D, Lokau J5, Floss DM, Piekorz R,
Dimitriadis E, Garbers C, Scheller J. Transcytosis of IL-11 and Apical Redirection of gp130 Is Mediated by IL-11? Receptor.
Cell Rep. 2016 Jul 26;16(4):1067-81. doi: 10.1016/j.celrep.2016.06.062. Epub 2016 Jul 14.

Kötter S, Kazmierowska M, Andresen C, Bottermann K, Grandoch M, Gorressen S, Heinen A, Moll J, Scheller J,
Gödecke A, Fischer JW, Schmitt JP, Krüger M. Circ Res. 2016 Sep 20. pii: CIRCRESAHA.116.309685. [Epub ahead of print]
Titin-Based Cardiac Myocyte Stiffening Contributes to Early Adaptive Ventricular
Remodeling After Myocardial Infarction. J Immunol. 2016 Oct 3. pii: 1600909. [Epub ahead of print]

Schumacher N, Schmidt S, Schwarz J, Dohr D, Lokau J, Scheller J, Garbers C,
Chalaris A, Rose-John S, Rabe B. Circulating Soluble IL-6R but Not ADAM17 Activation Drives Mononuclear
Cell Migration in Tissue Inflammation. J Immunol. 2016 Oct 3. pii: 1600909.

Abstract

Mothes B, Bucher K, Ammon-Treiber S, Schwab M, Piekorz RP, Hirsch E, Nürnberg B, Beer-Hammer S (2016).
p110g/d double deficiency induces eosinophilia and IgE production but protects from OVA-induced airway inflammation.
PLoS One, Published: July 21, 2016

Floss DM, Klöcker T, Schröder J, Lamertz L, Mrotzek S, Strobl B, Hermanns H, Scheller J. Defining the functional binding sites of Interleukin 12 receptor ?1 and Interleukin 23 receptor to Janus kinases.
Mol Biol Cell. 2016 May 18. pii: mbc.E14-12-1645.

Nitz R, Lokau J, Aparicio-Siegmund S, Scheller J, Garbers C. Modular organization of Interleukin-6 and Interleukin-11 ?-receptors.
Biochimie. 2015 Dec;119:175-82.

Geissler R, Simkin A, Floss D, Patel R, Fogarty EA, Scheller J, Grimson A. A widespread sequence-specific mRNA decay pathway mediated by hnRNPs A1 and A2/B1.
Genes Dev. 2016 May 1;30(9):1070-85.

Wolf J, Waetzig GH, Reinheimer TM, Scheller J, Rose-John S, Garbers C. A soluble form of the interleukin-6 family signal transducer gp130 is dimerized via a C-terminal disulfide bridge resulting from alternative mRNA splicing.
Biochem Biophys Res Commun. 2016 Feb 19;470(4):870-6.

Efimov GA, Kruglov AA, Khlopchatnikova ZV, Rozov FN, Mokhonov VV, Rose-John S, Scheller J, Gordon S, Stacey M, Drutskaya MS, Tillib SV, Nedospasov SA. Cell-type-restricted anti-cytokine therapy: TNF inhibition from one pathogenic source.
Proc Natl Acad Sci U S A. 2016 Mar 2. pii: 201520175.

Tsvetkov D, Shymanets A, Huang Y, Bucher K, Piekorz RP, Hirsch E, Beer-Hammer S, Harteneck C, Gollasch M, Nürnberg B (2016).
Better understanding of Phosphoinositide 3-Kinase pathways in the vasculature: Towards precision therapy targeting angiogenesis and tumor blood supply?
Biochemistry (Moscow) 2016 Jul;81(7):691-9. doi: 10.1134/S0006297916070051.

Franke M, Schröder J, Monhasery N, Ackfeld T, Hummel TM, Rabe B, Garbers C, Becker-Pauly C, Floss DM, Scheller J.
Human and murine Interleukin 23 receptors are novel substrates for a disintegrin and metalloproteases ADAM10 and ADAM17.
J Biol Chem.  2016 Mar 9. pii: jbc.M115.710541.

Lokau J, Nitz R, Agthe M, Monhasery N, Aparicio-Siegmund S, Schumacher N, Wolf J, Möller-Hackbarth K, Waetzig GH, Grötzinger J, Müller-Newen G, Rose-John S, Scheller J, Garbers C. Proteolytic Cleavage Governs Interleukin-11 Trans-signaling.
Cell Rep. 2016 Feb 23;14(7):1761-73. 

Nakhaei-Rad S, Nakhaeizadeh H, Götze S, Kordes C, Sawitza I, Hoffmann MJ, Franke M, Schulz WA, Scheller J, Piekorz RP, Häussinger D, Ahmadian MR. The role of embryonic stem cell-expressed RAS (ERAS) in the maintenance of quiescent hepatic stellate cells.
J Biol Chem. 2016 Feb 16. pii: jbc.M115.700088.

Sohn D, Peters D, Piekorz RP, Budach W, Jänicke RU (2016). miR-30e controls DNA damage-induced stress responses by modulating expression of the CDK inhibitor p21WAF1/CIP1 and caspase-3. Oncotarget,
Oncotarget. 2016 Mar 29;7(13):15915-29. doi: 10.18632/oncotarget.7432.

Lang A, Grether-Beck S, Singh M, Kuck F, Jakob S, Kefalas A, Altinoluk-Hambüchen S, Graffmann N, Schneider M, Lindecke A, Brenden H, Felsner I, Ezzahoini H,  Marini A, Weinhold S, Vierkötter A, Tigges J, Schmidt S, Stühler K, Köhrer K, Uhrberg M, Haendeler J, Krutmann J, Piekorz RP. MicroRNA-15b regulates mitochondrial ROS production and the senescence-associated secretory phenotype through sirtuin 4/SIRT4. Aging (US) 2016

Abstract

2015

 

Chronophin is a glial tumor modifier involved in the regulation of glioblastoma growth and invasiveness.
Schulze M, Fedorchenko O, Zink TG, Knobbe-Thomsen CB, Kraus S, Schwinn S, Beilhack A, Reifenberger G, Monoranu CM, Sirén AL, Jeanclos E, Gohla A.
Oncogene. 2015 Nov 9. doi: 10.1038/onc.2015.376.


Anti-interleukin-6 therapy through application of a monogenic protein inhibitor via gene delivery.
Görtz D, Braun GS, Maruta Y, Djudjaj S, van Roeyen CR, Martin IV, Küster A, Schmitz-Van de Leur H, Scheller J, Ostendorf T, Floege J, Müller-Newen G.  
Sci Rep. 2015 Oct 1;5:14685. doi: 10.1038/srep14685

Lacroix M, Rousseau F, Guilhot F, Malinge P, Magistrelli G, Herren S,Jones SA, Jones GW, Scheller J, Lissilaa R, Kosco-Vilbois M, Johnson Z, Buatois V, Ferlin W.
Novel insights into IL-6 cis- and trans-signaling pathways by differentially manipulating the assembly of the IL-6 signaling complex.
J Biol Chem. 2015 Sep 11. pii: jbc.M115.682138.

Floss, D., Schröder, J., Franke, M. & Scheller, J. (2015) Insights into IL-23 biology: From structure to function, Cytokine Growth Factor Rev. 2015 Jul 11. pii: S1359-6101(15)00053-2.

 Rose-John, S., Scheller, J. & Schaper, F. (2015) "Family reunion"
- A structured view on the composition of the receptor complexes of interleukin-6-type and
interleukin-12-type cytokines, Cytokine Growth Factor Rev. 2015 Jul 6. pii: S1359-6101(15)-3.

Oyanedel CN, Kelemen E, Scheller J, Born J, Rose-John S.
Peripheral and central blockade of interleukin-6 trans-signaling differentially affects sleep architecture Brain Behav Immun. 2015 Jul 2. pii: S0889-1591(15)00235-4.

Nakhaei-Rad S1, Nakhaeizadeh H1, Kordes C2, Cirstea IC3, Schmick M4, Dvorsky R1, Bastiaens PI4, Häussinger D2, Ahmadian MR5.he Function of Embryonic Stem Cell-expressed RAS (E-RAS), a Unique RAS Family Member, Correlates with Its Additional Motifs and Its Structural Properties.
J Biol Chem. 2015 Jun 19;290(25):15892-903.

Vasudharani Devanathan, Ina Hagedorn, David Köhler, Katja Pexa, Deya
Cherpokova, Peter Kraft, Madhurendra Singh, Peter Rosenberger, Guido Stolle, Lutz
Birnbaumer, Roland Piekorz, Sandra Beer-Hammer, Bernhard Nieswandt, Bernd Nürnberg
Platelet G?i2 is an essential mediator of thrombo-inflammatory organ damage in mice.
Proc Natl Acad Sci U S A. 2015 May 19;112(20):6491-6. 

Schröder J, Moll JM, Baran P, Grötzinger J, Scheller J, Floss DM.
Non-canonical Interleukin 23 receptor complex assembly: p40 recruits Interleukin 12 Receptor beta 1 via site II and induces p19/Interleukin 23 Receptor interaction via site III.
J Biol Chem.  2015 Jan 2;290(1):359-70.

Abstract

 

2014

 

Müller J, Gorressen S, Grandoch M, Feldmann K, Kretschmer I, Lehr S, Ding Z, Schmitt JP, Schrader J, Garbers C, Heusch G, Kelm M, Scheller J, Fischer JW.
Interleukin-6-dependent phenotypic modulation of cardiac fibroblasts after acute myocardial infarction.
Basic Res Cardiol. 2014 ;109(6):440.

Karbach S, Croxford AL, Oelze M, Schüler R, Minwegen D, Wegner-Kops J, Koukes L, Yogev N, Nikolaev A, Reißig S, Ullmann A, Knorr M, Waldner M, Neurath M, Li H, Wu Z, Brochhausen C, Scheller J, Rose-John S, Piotrowski C, Bechmann I, Radsak M, Wild P, DaiberA, von Stebut E, Wenzel P, Waisman A, Münzel T.
Interleukin 17 Drives Vascular Inflammation, Endothelial Dysfunction, and Arterial Hypertension in Psoriasis-Like Skin Disease.
Arterioscler Thromb Vasc Biol. 2014 34(12):2658-68.

Aparicio-Siegmund S, Moll JM, Lokau J, Grusdat M, Schröder J, Plöhn S, Rose-John S, Grötzinger J, Lang PA, Scheller J, Garbers C.  
Recombinant p35 from Bacteria Can Form Interleukin (IL-)12, but Not IL-35.
PLoS One. 2014  26;9(9):e107990 .

Schönberger T, Jürgens T, Müller J, Armbruster N, Niermann C, Gorressen S, Sommer J, Tian H, di Paolo G, Scheller J, Fischer JW, Gawaz M, Elvers M.
Pivotal Role of Phospholipase D1 in Tumor Necrosis Factor-?-Mediated Inflammation and Scar Formation after Myocardial Ischemia and Reperfusion in Mice.
Am J Pathol. 2014  184(9):2450-64.

Marczynska J, Ozga A, Wlodarczyk A, Majchrzak-Gorecka M, Kulig P, Banas M, Michalczyk-Wetula D, Majewski P, Hutloff A, Schwarz J, Chalaris A, Scheller J, Rose-John S, Cichy J. The Role of Metalloproteinase ADAM17 in Regulating ICOS Ligand-Mediated Humoral Immune Responses.
J Immunol. 2014  15;193(6):2753-63.

Sommer J, Engelowski E, Baran P, Garbers C, Floss DM, Scheller J.
Interleukin-6, but not the interleukin-6 receptor plays a role in recovery from dextran sodium sulfate-induced colitis.
Int J Mol Med. 2014  34(3):651-60.

Sommer J, Garbers C, Wolf J, Trad A, Moll JM, Sack M, Fischer R, Grötzinger J, Waetzig GH, Floss DM, Scheller.
Alternative intronic polyadenylation generates the interleukin-6 trans-signaling inhibitor SGP130-E10.
J Biol Chem. 2014  8;289(32):22140-50. 

Garbers C1, Monhasery N2, Aparicio-Siegmund S2, Lokau J3, Baran P2, Nowell MA4, Jones SA4, Rose-John S3, Scheller J.
The Interleukin-6 Receptor Asp358Ala Single Nucleotide Polymorphism rs2228145 Confers Increased Proteolytic Conversion Rates by ADAM Proteases.
Biochim Biophys Acta. 2014 1842(9):1485-94.

Wagener EM, Aurich M, Aparicio-Siegmund S, Floss DM, Garbers C, Breusing K, Rabe B, Schwanbeck R, Grötzinger J, Rose-John S, Scheller J.
The amino acid exchange R28E in ciliary neurotrophic factor (CNTF) abrogates IL-6R- but retains CNTFR-dependent signaling via gp130/LIFR.
J Biol Chem. 2014   289(26):18442-50.

Düsterhöft S, Höbel K, Oldefest M, Lokau J, Waetzig GH, Chalaris A, Garbers C, Scheller J, Rose-John S, Lorenzen I, Grötzinger J.
"A Disintegrin And Metalloprotease-17 Dynamic interaction sequence" (CANDIS) - the sweet tooth for the human interleukin 6receptor.
J Biol Chem. 2014  6;289(23):16336-48.

Dewitz C1, Möller-Hackbarth K, Schweigert O, Reiss K, Chalaris A, Scheller J, Rose-John S.
T-cell immunoglobulin and mucin domain 2 (TIM-2) is a target of ADAM10-mediated ectodomain shedding.
FEBS J. 2014 281(1):157-74.

Flex E1, Jaiswal M, Pantaleoni F, Martinelli S, Strullu M, Fansa EK, Caye A, De Luca A, Lepri F, Dvorsky R, Pannone L, Paolacci S, Zhang SC, Fodale V, Bocchinfuso G, Rossi C, Burkitt-Wright EM, Farrotti A, Stellacci E, Cecchetti S, Ferese R, Bottero L, Castro S, Fenneteau O, Brethon B, Sanchez M, Roberts AE, Yntema HG, Van Der Burgt I, Cianci P, Bondeson ML, Cristina Digilio M, Zampino G, Kerr B, Aoki Y, Loh ML, Palleschi A, Di Schiavi E, Carè A, Selicorni A, Dallapiccola B, Cirstea IC, Stella L, Zenker M, Gelb BD, Cavé H, Ahmadian MR, Tartaglia M.
Activating mutations in RRAS underlie a phenotype within the RASopathy spectrum and contribute to leukaemogenesis.Hum Mol Genet. 2014  15;23(16):4315-27. 

Jaiswal M1, Dvorsky R, Amin E, Risse SL, Fansa EK, Zhang SC, Taha MS, Gauhar AR, Nakhaei-Rad S, Kordes C, Koessmeier KT, Cirstea IC, Olayioye MA, Häussinger D, Ahmadian MR.
Functional crosstalk between Ras and Rho pathways: p120RasGAP competitively inhibits the RhoGAP activity of Deleted in Liver Cancer (DLC) tumor suppressors by masking its catalytic arginine finger.
J Biol Chem. 2014  7;289(10):6839-49.

Croxford AL, Karbach S, Kurschus FC, Wörtge S, Nikolaev A, Yogev N, Klebow S, Schüler R, Reissig S, Piotrowski C, Brylla E, Bechmann I, Scheller J, Rose-John S, Wunderlich FT, Münzel T, von Stebut E, Waisman A.
IL-6 Regulates Neutrophil Microabscess Formation in IL-17A-Driven Psoriasiform Lesions.
Journal of Investigative Dermatology (2014) 134, 728–735.

Krieg, A.Mersch, S.Boeck, I.Dizdar, L.Weihe, E.Hilal, Z.Krausch, M.Mohlendick, B.Topp, S. A.Piekorz, R. P.Huckenbeck, W.Stoecklein, N. H.Anlauf, M.Knoefel, W. T.
New Model for Gastroenteropancreatic Large-Cell Neuroendocrine Carcinoma: Establishment of Two Clinically Relevant Cell Lines.
PLoS One. 2014 14;9(2):e88713. 

Olga Schweigerta,Christin Dewitza,Katja Möller-Hackbartha,Ahmad TradaChristoph Garbersb,Stefan Rose-Johna,Jürgen Scheller, Soluble T cell immunoglobulin and mucin domain (TIM)-1 and -4 generated by A Disintegrin And Metalloprotease (ADAM)-10 and -17 bind to phosphatidylserine.
Biochim Biophys Acta. 2014 1843(2):275-87.

Mohamed S. Taha,Kazem Nouri,Lech G. Milroy, Jens M. Moll,Christian Herrmann, Luc Brunsveld, Roland P. Piekorz, Mohammad R. Ahmadian.
Subcellular Fractionation and Localization Studies Reveal a Direct Interaction of the Fragile X Mental Retardation Protein (FMRP) with Nucleolin.
PLoS One. 2014  21;9(3):e91465.

Thakur HC1, Singh M, Nagel-Steger L, Kremer J, Prumbaum D, Fansa EK, Ezzahoini H, Nouri K, Gremer L, Abts A, Schmitt L, Raunser S, Ahmadian MR, Piekorz RP.
The centrosomal adaptor TACC3 and the microtubule polymerase chTOG interact via defined C-terminal subdomains in an Aurora-A kinase-independent manner.
J Biol Chem. 2014  3;289(1):74-88.

Trilling M1, Le VT, Rashidi-Alavijeh J, Katschinski B, Scheller J, Rose-John S, Androsiac GE, Jonjic S, Poli V, Pfeffer K, Hengel H.
"Activated" STAT proteins: a paradoxical consequence of inhibited JAK-STAT signaling in cytomegalovirus-infected cells.
J. Virol.  2014  23 13638-13650 .

Abe M, Yuki Y, Kurokawa S, Mejima M, Kuroda M, Park EJ, Scheller J, Nakanishi U, Kiyono H.
A rice-based soluble form of a murine TNF-specific llama variable domain of heavy-chain antibody suppresses collagen-induced arthritis in mice.
J Biotechnol. 2014 168-1656(14)00078-9.

Campbell IL, Erta M, Lim SL, Frausto R, May U, Rose-John S, Scheller J, Hidalgo J.
Trans-signaling is a dominant mechanism for the pathogenic actions of interleukin-6 in the brain.
J Neurosci. 2014 12;34(7):2503-13.

Abstract

 

2013

 

Scheller J, Garbers C, Rose-John S.
Interleukin-6: From basic biology to selective blockade of pro-inflammatory activities.
Semin Immunol. 2013 1044-5323(13)00119.

Mayer S, Kumar R, Jaiswal M, Soykan T, Ahmadian MR, Brose N, Betz H, Rhee JS,
Papadopoulos T. Collybistin activation by GTP-TC10 enhances postsynaptic gephyrin
clustering and hippocampal GABAergic neurotransmission.
Proc Natl Acad Sci U S A 2013 17;110(51):20795-800.

Rho-kinase: regulation, (dys)function, and inhibition.
Amin E, Dubey BN, Zhang SC, Gremer L, Dvorsky R, Moll JM, Taha MS, Nagel-Steger L, Piekorz RP, Somlyo AV, Ahmadian MR.
Rho-kinase: regulation, (dys)function, and inhibition.
Biol Chem. 2013  1;394(11):1399-410. 

Cirstea IC, Gremer L, Dvorsky R, Zhang SC, Piekorz RP, Zenker M, Ahmadian MR. .
Diverging gain-of-function mechanisms of two novel KRAS mutations associated with Noonan and cardio-facio-cutaneous syndromes. Hum Mol Genet.
Epub 2013 15;22(2):262-70. 

Interaction characteristics of Plexin-B1 with Rho family proteins.
Fansa EK, Dvorsky R, Zhang SC, Fiegen D, Ahmadian MR.Biochem Biophys Res Commun.
Interaction characteristics of Plexin-B1 with Rho family proteins
Epub 2013 17;434(4):785-90.



Risse SL, Vaz B, Burton MF, Aspenström P, Piekorz RP, Brunsveld L, Ahmadian MR.
SH3-mediated targeting of Wrch1/RhoU by multiple adaptor proteins.
Biol Chem. 2013 394(3):421-32.


Jaiswal M, Fansa EK, Dvorsky R, Ahmadian MR.
New insight into the molecular switch mechanism of human Rho family proteins: shifting a paradigm.
Biol Chem. 2013 394(1):89-95. 

Schweigert O, Dewitz C, Möller-Hackbarth K, Trad A, Garbers C, Rose-John S, Scheller J.
Soluble T cell immunoglobulin and mucin domain (TIM-) 1 and 4 generated by A Disintegrin And Metalloproteases (ADAM-)10 and 17 bind to phosphatidylserine.
Biochim Biophys Acta. 2013  167-4889(13)00406-0. 

Möller-Hackbarth K, Dewitz C, Schweigert O, Trad A, Garbers C, Rose-John S, Scheller J.
ADAM10 AND ADAM17 are major sheddases of T cell immunoglobulin and mucin domain 3 (TIM-3).
J Biol Chem. 2013 288(48):34529-44.

Croxford AL, Karbach S, Kurschus FC, Wörtge S, Nikolaev A, Yogev N, Klebow S, Schüler R, Reissig S,
Piotrowski C, Brylla E, Bechmann I, Scheller J, Rose-John S, Wunderlich FT, Münzel T, von Stebut E,
Waisman A.
IL-6 Regulates Neutrophil Microabscess Formation in IL-17A-Driven Psoriasiform Lesions.
J Invest Dermatol. 2014 134(3):728-35.



Garbers C, Kuck F, Aparicio-Siegmund S, Konzak K, Kessenbrock M, Sommerfeld A, Häussinger D,
Lang PA, Brenner D, Mak TW, Rose-John S, Essmann F, Schulze-Osthoff K, Piekorz RP, Scheller J.
Cellular senescence or EGFR signaling induces Interleukin 6 (IL-6) receptor expression controlled by mammalian target of rapamycin (mTOR).
Cell Cycle. 2013 1;12(21):3421-32

  

Thakur HC, Singh M, Nagel-Steger L, Prumbaum D, Kalawy Fansa E, Gremer L, Ezzahoini H, Abts A, Schmitt L, Raunser S, Ahmadian MR, Piekorz RP.
Role of centrosomal adaptor proteins of the TACC family in the regulation of microtubule dynamics during mitotic cell division.
Biol Chem. 2013  394(11):1411-23. 



Braun O, Dewitz C, Möller-Hackbarth K, Scheller J, Schiffelholz T, Baier PC, Rose-John S.
Effects of blockade of peripheral interleukin-6 trans-signaling on hippocampus-dependent and independent memory in mice.
J Interferon Cytokine Res.
J Interferon Cytokine Res. 2013  33(5):254-60. 



Spehlmann ME, Manthey CF, Dann SM, Hanson E, Sandhu SS, Liu LY, Abdelmalak FK, Diamanti MA, Retzlaff K, Scheller J, Rose-John S, Greten FR, Wang JY, Eckmann L.
Trp53 Deficiency Protects against Acute Intestinal Inflammation.
J Immunol. 2013  15;191(2):837-47



Judith Hoge, Isabell Yan, Nathalie Janner, Valea Schumacher, Athena Chalaris, Oliver M. Steinmetz, Daniel R. Engel, Jurgen Scheller, Stefan Rose-John, and Hans-Willi Mittrucker
IL-6 Controls the Innate Immune Response against Listeria monocytogenes via Classical IL-6 Signaling
J Immunol. 2013  15;190(2):703-11

Christoph Garbers, Bjorn Spudy, Samadhi Aparicio-Siegmund, Georg H. Waetzig, Jan Sommer, Christoph Holscher, Stefan Rose-John, Joachim Grotzinger, Inken Lorenzen, and Jürgen Scheller
An interleukin -6 receptor-dependent molecular switch mediates signal transduction of the IL-27 cytokine subunit p28 (IL-30) via a gp130 receptor homodimer.
J Biol Chem. 2013  8;288(6):4346-54

Garbers C, Scheller J.
Interleukin-6 and interleukin-11: same same but different.
Biol Chem. 2013  394(9):1145-61

Doreen M. Floss, Simone Mrotzek, Tobias Klöcker, Jutta Schröder, Joachim Grözinger, Stefan Rose-John, and Jürgen Scheller
Identification of canonical tyrosine-dependent and non-canonical tyrosine-independent STAT3 activation sites in the intracellular domain of the interleukin 23 receptor.
J Biol Chem. 2013  5;288(27):19386-400.

Baran P, Nitz R, Grötzinger J, Scheller J, Garbers C.
Minimal interleukin (IL-)6 receptor stalk composition for IL-6R shedding
and IL-6 classic signaling.
J Biol Chem. 2013  24;288(21):14756-68.

Abstract

Phan HT, Pohl J, Floss DM, Rabenstein F, Veits J, Le BT, Chu HH, Hause G, Mettenleiter T, Conrad U.
ELPylated haemagglutinins produced in tobacco plants induce potentially neutralizing
antibodies against H5N1 viruses in mice.
Plant Biotechnol J. 2013 11(5):582-93.


Risse SL; Vaz B, Burton M, Aspenström P, Piekorz RP, Brunsveld L, Ahmadian MR (2013).
SH3-mediated targeting of Wrch1/RhoU by multiple adaptor proteins. Biol. Chem., 394, 421-432.
Biol Chem. 2013 394(3):421-32. 

Luca AC, Deenen R, Mersch S, Schmidt S, Messner I, Schäfer KL, Baldus SE, Huckenbeck W, Piekorz RP, Knoefel WT, Krieg A, Stoecklein NH.
Impact of the 3D microenvironment on phenotype, gene expression,
and EGFR inhibition of colorectal cancer cell lines.
PLoS One,  2013  8(3):e59689



Pietkiewicz S, Sohn D, Piekorz RP, Grether-Beck S, Budach W, Sabapathy K,
Jänicke RU.
Oppositional regulation of Noxa by Jnk1 and Jnk2 during apoptosis induced by proteasomal
inhibitors.
PLoS One, 2013 8(4):e61438

Jaiswal M, Kalawy Fansa E, Dvorsky R, Ahmadian R.
New insight into the molecular switch mechanism of human Rho family proteins: shifting a paradigm.
Biol Chem. 2013  394(3):421-32.


Jaiswal M, Dvorsky R, Ahmadian MR.
Deciphering the molecular and functional basis of Dbl family proteins: A novel systematic
approach towards classification of selective activation of the Rho family proteins.
J Biol Chem. 2013  8;288(6):4486-500.

Abstract

 

Risse SL, Vaz B, Burton MF, Aspenström P, Piekorz RP, Brunsveld L, Ahmadian MR.
SH3-mediated targeting of Wrch1/RhoU by multiple adaptor proteins.
Biol Chem. 2013 394(3):421-32.

Valeska Hauptmann, Nicola Weichert, Matthias Menzel, Dominic Knoch, Norman Paege, Jürgen Scheller, Uwe Spohn, Udo Conrad und Mario Gils.
Native-sized spider silk proteins synthesized in planta via intein-based
multimerization.
Transgenic Res. 2013 22(2):369-77.


Abstract


 

2012




Recombinant IL-6 treatment protects mice from organ specific autoimmune
disease by IL-6 classical signalling-dependent IL-1ra induction.
Samavedam UK, Kalies K, Scheller J, Sadeghi H, Gupta Y, Jonkman MF, Schmidt E, Westermann J, Zillikens D, Rose-John S, Ludwig RJ.
J Autoimmun. 2013 40:74-85. 

Scheller J, Rose-John S.
The interleukin 6 pathway and atherosclerosis.
Lancet. 2012  28;380(9839):338.

Abstract

Garbers C, Hermanns HM, Schaper F, Müller-Newen G, Grötzinger J, Rose-John S, Scheller J.
Plasticity and cross-talk of Interleukin 6-type cytokines.
Cytokine Growth Factor Rev. 2012 23(3):85-97.



I Lorenzen, J Lokau, S Dusterhoft, A Trad, C Garbers, J Scheller, S Rose-John, and J Grotzinger
The membrane-proximal domain of A Disintegrin and Metalloprotease 17
(ADAM17) is responsible for recognition of the interleukin-6 receptorand interleukin-1 receptor II.
FEBS Lett 24  2012 586(8): p. 1093

M Schaab, H Kausch, J  Klammt, M  Nowicki, U  Anderegg, R  Gebhardt,
S  Rose-John, J  Scheller, J  Thiery, J  Kratzsch
Novel Regulatory Mechanisms for Generation of the Soluble Leptin Receptor: Implications for Leptin Action
PLos ONE   2012  7(4):e34787.


Yamamoto K, Trad A, Baumgart A, Hüske L, Lorenzen I, Chalaris A, Grötzinger J, Dechow T, Scheller J, Rose-John S. A novel bispecific single-chain antibody for ADAM17 and CD3 induces T-cell mediated lysis of prostate cancer cells.
Biochem J. 2012  1;445(1):135-44.



Suthaus J, Stuhlmann-Laeisz C, Tompkins VS, Rosean TR, Klapper W, Tosato
G, Janz S, Scheller J, Rose-John S.HHV8 encoded viral IL-6 collaborates with mouse IL-6 in MCD-like
development in mice.
Blood. 2012 31;119(22):5173-81. 



Sommer J, Effenberger T, Volpi E, Waetzig GH, Bernhardt M, Suthaus J, Garbers C, Rose-John S, Floss DM, Scheller J.Constitutively active mutant GP130 receptor protein from inflammatory hepatocellular adenoma is inhibited by an anti-GP130 antibody which specifically neutralize
IL-11-signaling.
J Biol Chem. 2012  20;287(17):13743-51. 



Sodenkamp J, Waetzig GH, Scheller J, Seegert D, Grötzinger J, Rose-John
S, Ehlers S, Hölscher C. Therapeutic targeting of interleukin-6
trans-signaling does not affect the outcome of experimental
tuberculosis. Immunobiology. 2012 Jan 20. [Epub ahead of print]


Abstract


The p101 subunit of PI3K? restores activation by Gß mutants deficient in stimulating p110?.
Shymanets A, Ahmadian MR, Kössmeier KT, Wetzker R, Harteneck C, Nürnberg B.
The p101 subunit of PI3K? restores activation by Gß mutants deficient in stimulating p110?.
Biochem J. 2012 Feb 1;441(3):851-8.



Jaiswal M, Dubey BN, Koessmeier KT, Gremer L, Ahmadian MR. Biochemical assays to characterize Rho GTPases.
Methods Mol Biol. 2012;827:37-58. PMID: 22144266


Abstract



Marieke A. M. Frasa, Katja T. Koessmeier, M. Reza Ahmadian & Vania M. M. Braga (2012) Illuminating the functional and structural repertoire of human TBC/RABGAPs. Nature Reviews Molecular Cell Biology, advance online publication, Published online 18 January 2012 | doi:10.1038/nrm3267



Putz EM, Prchal M, Simma OA, Forster F, Koenig X, Stockinger H, Piekorz RP, Freissmuth M,
Müller M, Sexl V, Zebedin E (2012). PI3K? is essential for tumor clearance mediated by
cytotoxic T lymphocytes. PLoS One, in press. 

 

Wiege K, Ali SR, Gewecke B, Novakovic A, Konrad FM, Pexa K, Beer-Hammer S, Reutershan J, Piekorz RP, Schmidt RE, Nürnberg B, Gessner JE (2012). G?i2 is the essential G?i protein in immune complex-induced lung disease. J. Immunol., in press.


Cirstea IC, Gremer L, Dvorsky R, Zhang S-C, Piekorz RP, Zenker M, Ahmadian MR (2012). Diverging gain-of-function mechanisms of two novel KRAS mutations associated with Noonan and Cardio-Facio-Cutaneous syndromes. Hum. Mol. Genet., doi:10.1093/hmg/dds426

 

Wiege K, Le DD, Seyd SN, Ali SR, Novakovic A, Beer-Hammer S, Piekorz RP, Schmidt RE, Nürnberg B, Gessner JE (2012). Defective macrophage migration in G?i2- but not G?i3-deficient mice. J. Immunol., 189, 980-987.

Abstracht

 

 

2011



Scheller, J., Chalaris, A., Garbers, C., and Rose-John, S. 2011. :  ADAM17: a molecular switch to control inflammation and tissue regeneration. Trends Immunol 32 (8): 380-7.

 

Scheller, J., Chalaris, A., Schmidt-Arras, D., and Rose-John, S. 2011. The pro- and anti-inflammatory properties of the Cytokine Interleukin-6. Biochim Biophys Acta - Mol Cell Res 1813:878-888.

 

Kushnir S, Cirstea IC, Basiliya L, Lupilova N, Breitling R, Alexandrov K. Artificial linear episome-based protein expression system for protozoon Leishmania tarentolae. Mol Biochem Parasitol. 2011 Apr;176(2):69-79. PMID: 21167214



Stark Z, Gillessen-Kaesbach G, Ryan MM,Cirstea IC, Gremer L, Ahmadian MR, Savarirayan R, Zenker M. Two novel germline KRAS mutations: expanding the molecular and clinical phenotype.
Clin Genet. 2011 Jul 28.   PMID: 21797849

 


Kraft M,Cirstea IC, Voss AK, Thomas T, Goehring I, Sheikh BN, Gordon L, ScottH,  Smyth GK, Ahmadian MR, Trautmann U, Zenker M, Tartaglia M, Ekici A, Reis A, Dörr HG, Rauch A, Thiel CT.Kraft M: Disruption of the histone acetyltransferase MYST4 leads to a Noonan syndrome-like phenotype and hyperactivated MAPK signaling in humans and mice.


Abstract

 

Gremer L: Germline KRAS mutations cause aberrant biochemical and physical properties leading to developmental disorders.


Abstract

 

Ismail SA: Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo.

Abstract


Scholz RP: The tumor suppressor protein DLC1 is regulated by PKD-mediated GAP domain phosphorylation.

 

Malchow, S., Thaiss, W., Jänner, N., Waetzig, G.H., Gewiese-Rabsch, J., Garbers, C., Yamamoto, K., Rose-John, S., and Scheller, J. 2011. Essential role of neutrophil mobilization in concanavalin A-induced hepatitis is based on classic IL-6 signaling but not on IL-6 trans-signaling. Biochim Biophys Acta 1812:290-301.

 

Jones SA: Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling.

Abstract


Conrad U: ELPylated anti-human TNF therapeutic single-domain antibodies for prevention of lethal septic shock.

 

Scheller, J., Chalaris, A., Schmidt-Arras, D., and Rose-John, S. 2011. The pro- and anti-inflammatory properties of the Cytokine Interleukin-6. Biochim Biophys Acta - Mol Cell Res 1813:878-888.

 

Kruglov, A.A., Tumanov, A.V., Grivennikov, S.I., Shebzukhov, Y.V., Kuchmiy, A.A., Efimov, G.A., Drutskaya, M.S., Scheller, J., Kuprash, D.V., and Nedospasov, S.A. 2011. Modalities of Experimental TNF Blockade In Vivo: Mouse Models. Adv Exp Med Biol 691:421-431.

Abstract

 

Garbers, C., Jänner, N., Chalaris, A., Moss, M.L., Floss, D.M., Meyer, D., Koch-Nolte, F., Rose-John, S., and Scheller, J. 2011. Species specificity of ADAM10 and ADAM7 in IL-6 transsignaling and novel role of ADAM10 in inducible IL-6R shedding. J Biol Chem [Epub ahead of print].

Abstract


Chalaris, A., Garbers, C., Rabe, B., Rose-John, S., and Scheller, J. 2011. The soluble Interleukin 6 receptor: Generation and role in inflammation and cancer. Eur J Cell Biol Epub ahead of print doi:10.1016/j.ejcb.2010.10.007.


Barkhausen, T., Tschernig, T., Rosenstiel, P., van Griensven, M., Vonberg, R.P., Dorsch, M., Mueller-Heine, A., Chalaris, A., Scheller, J., Rose-John, S., et al. 2011. Selective blockade of interleukin-6 trans-signaling improves survival in a murine polymicrobial sepsis model. Crit Care Med Epub ahead of print.

Abstract


Dizayee S, Kaestner S, Kuck F, Hein P, Klein C, Piekorz RP, Meszaros J, Matthes J, Nürnberg B, Herzig S. Gai2- and Gai3-specific regulation of voltage-dependent L-type calcium channels in cardiomyoctes. PLoS One, in press.


Luk SK, Piekorz RP, Nürnberg B, To SST. The catalytic phosphoinositol 3-kinase p110d is required for glioma cell migration and invasion. Eur. J. Cancer, in press.

Jaiswal M: Mechanistic insights into specificity, activity, and regulatory elements of the regulator of G-protein signaling (RGS)-containing Rho-specific guanine nucleotide exchange factors (GEFs) p115, PDZ-RhoGEF (PRG), and leukemia-associated RhoGEF (LARG).

von Holleben M: The immunoinhibitory adapter protein SRC homology domain 3 lymphocyte protein 2 (SLy2) regulates actin dynamics and B cell spreading.

Abstract

 

 

2010



Schmidt S, Essmann F, Cirstea IC, Kuck F, Thakur HC, Singh M, Kletke A, Jänicke RU, Wiek C, Hanenberg H, Ahmadian MR, Schulze-Osthoff K, Nürnberg B, Piekorz RP. The centrosome and mitotic spindle apparatus in cancer and senescence. Cell Cycle. 2010 Nov 20;9(22). [Epub ahead of print]

Scholz RP, Gustafsson JO, Hoffmann P, Jaiswal M, Ahmadian MR, Eisler S, Erlmann P, Schmid S, Hausser A, Olayioye MA. The tumor suppressor protein DLC1 is regulated by PKD-mediated GAP domain phosphorylation. Exp Cell Res. 2010 Nov 15. [Epub ahead of print]

Schmidt S, Schneider L, Essmann F, Cirstea IC, Kuck F, Kletke A, Jänicke RU, Wiek C, Hanenberg H, Ahmadian MR, Schulze-Osthoff K, Nürnberg B, Piekorz RP. The centrosomal protein TACC3 controls paclitaxel sensitivity by modulating a premature senescence program. Oncogene. 2010 Aug 23. [Epub ahead of print]

Lothar Gremer*, Torsten Merbitz-Zahradnik*, Radovan Dvorsky*, Ion C. Cirstea*, Christian Peter Kratz, Martin Zenker, Alfred Wittinghofer, Mohammad Reza Ahmadian. Germline KRAS mutations cause aberrant biochemical and physical properties leading to developmental disorders. Hum Mutat. 2010 Oct 14. [Epub ahead of print]. *, equal contribution.

Cirstea IC, Kutsche K, Dvorsky R, Gremer L, Carta C, Horn D, Roberts AE, Lepri F, Merbitz-Zahradnik T, König R, Kratz CP, Pantaleoni F, Dentici ML, Joshi VA, Kucherlapati RS, Mazzanti L, Mundlos S, Patton MA, Silengo MC, Rossi C, Zampino G, Digilio C, Stuppia L, Seemanova E, Pennacchio LA, Gelb BD, Dallapiccola B, Wittinghofer A, Ahmadian MR, Tartaglia M, Zenker M. A restricted spectrum of NRAS mutations causes

Noonan syndrome. Nat Genet. 2010 Jan;42(1):27-9.

Gremer L, De Luca A, Merbitz-Zahradnik T, Dallapiccola B, Morlot S, Tartaglia M, Kutsche K, Ahmadian MR, Rosenberger G. Duplication of Glu37 in the switch I region of HRAS impairs effector/GAP binding and underlies Costello syndrome by promoting enhanced growth factor-dependent MAPK and AKT activation. Hum Mol

Genet. 2010 Mar 1;19(5):790-802.

Gomez-Baldo L, Schmidt S, Maxwell CA, Bonifaci N, Gabaldon T, Vidalain PO, Senepedis W, Kletke A, Rosing M, Barnekow A, Rottapel R, Capella G, Vidal M, Astrinidis A*, Piekorz RP*, Pujana MA*. TACC3-TSC2 maintains nuclear envelope structure and controls cell division. Cell Cycle, 9, 1143-1155 (*korrespondierende Autoren).

Beer-Hammer S*, Zebedin E, von Holleben M, Alferink J, Reis B, Dresing P, Degrandi D, Scheu S, Hirsch E, Sexl V, Pfeffer K, Nürnberg B, Piekorz RP* (2010). Contribution of the catalytic PI3K isoforms p110g and p110g to B cell development and maintenance, transformation and proliferation. (*korrespondierende Autoren)., J. Leukoc. Biol., 87, 1083-1095.

Piekorz RP (2010). Dissecting the role of INCENP-Aurora B in chromosome alignment, spindle assembly, checkpoint activity, and cytokinesis. N&V. Cell Cycle, 9(9), 1-2.

Stan A, Pielarski KN, Brigadski T, Wittenmayer N, Fedorchenko O, Gohla A, Lessmann V, DresbaT, Gottmann  K.

Institute for Neuro- and Sensory Physiology, Biologisch-Medizinisches Forschungszentrum, Heinrich-Heine University Düsseldorf, 40225 Düsseldorf, Germany.

Frasa MA, Maximiano FC, Smolarczyk K, Francis RE, Betson ME, Lozano E, Goldenring J, Seabra MC, Rak A, Ahmadian MR, Braga VM. Armus is a Rac1 effector that inactivates Rab7 and regulates E-cadherin

degradation. Curr Biol. 2010 Feb 9;20(3):198-208.

Gazdag EM, Cirstea IC, Breitling R, Lukes J, Blankenfeldt W and Alexandrov K. Purification and crystallization of human Cu/Zn superoxide dismutase recombinantly produced in the protozoan Leishmania tarentolae. Acta Cryst. (August 2010). F66, 871–877.

Chen YX, Koch S, Uhlenbrock K, Weise K, Das D, Gremer L, Brunsveld L, Wittinghofer A, Winter R, Triola G,

Waldmann H. Synthesis of the Rheb and K-Ras4B GTPases. Angew Chem Int Ed Engl. 2010 Jul 22.

Rosnizeck IC, Graf T, Spoerner M, Tränkle J, Filchtinski D, Herrmann C, Gremer L, Vetter IR, Wittinghofer A, König B, Kalbitzer HR. Stabilizing a weak binding state for effectors in the human ras protein by cyclen complexes. Angew Chem Int Ed Engl. 2010 May 17;49(22):3830-3.

Schmidt S, Schneider L, Essmann F, Cirstea IC, Kuck F, Kletke A, Jänicke RU, Wiek C, Hanenberg H, Ahmadian MR, Schulze-Osthoff K, Nürnberg B, Piekorz RP (2010). The centrosomal protein TACC3 controls paclitaxel sensitivity by modulating a premature senescence program. Oncogene, in press.



2009

 

 

Kurig B, Shymanets A, Bohnacker T, Prajwal, Brock C, Ahmadian MR, Schaefer M, Gohla A, Harteneck C,

Wymann MP, Jeanclos E, Nürnberg B.

Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20312-7. Epub 2009 Nov 11.PMID: 19906996 [PubMed - in process] Related articles

Eberth, A. and Ahmadian, M.R. In vitro GEF and GAP assays. Curr. Protoc. Cell Biol., 2009 Jun;Chapter

14:Unit 14.9.

Shymanets, A., Ahmadian, M.R. and Nürnberg, B. (2009) G??-copurified lipid kinase impurity from Sf9 cells. Protein Pept Lett. 2009 Sep 10. [Epub ahead of print].

Eberth, A., Lundmark, R., Gremer, L., Dvorsky, R., Koessmeier, K.T., McMahon, H.T. and Ahmadian, M.R. (2009) A BAR domain-mediated autoinhibitory mechanism for RhoGAPs of the GRAF family. Biochem. J. 417, 371-377.

Albarrán-Juárez J*, Gilsbach R*, Piekorz RP, Pexa K, Beetz N, Schneider J, Nürnberg B, Birnbaumer L, Hein L (2008). Modulation of a2-adrenoceptor functions by heterotrimeric Gai isoforms. J. Pharmacol. Exp. Ther., 331, 35-44.

Abstract

 2008

 

 

Gremer, L., Gilsbach, B., Ahmadian, M.R. and Wittinghofer, A. (2008) Fluoride complexes of oncogenic Ras mutants to study the Ras-RasGAP-interaction. Biol. Chem. 389, 1163-1171.

Gasper, R., Thomas, C., Ahmadian, M.R. and Wittinghofer, A. (2008) The role of the conserved switch II glutamate in guanine nucleotide exchange factor-mediated nucleotide exchange of GTP-binding proteins. J. Mol. Biol. 379, 51-63.

Pena, V., Hothorn, M., Eberth, A., Kaschau, N., Parret, A., Gremer, L., Bonneau, F., Ahmadian, M.R. and Scheffzek, K. (2008) The C2 domain of synGAP is essential for stimulation of the Rap GTPase reaction. EMBO Rep., 9, 344–349.

Klionsky D., ..... Gohla A., ..... Nürnberg B., et al. (2008): Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy, volume 4 | issue 2 Pages: 151 - 175

Gasper R., Thomas C., Ahmadian MR., Wittinghofer A. (2008):The role of the conserved switch II glutamate in guanine nucleotide exchange factor-mediated nucleotide exchange of GTP-binding proteins.J Mol Biol, 379: 51-63.

Zebedin E, Simma O, Schuster C, Fajmann S, Eckelhart E, Warsch W, Putz, EM, Eckelhart E,

Stoiber D, Weisz E, Schmid JE, Pickl W, Valent P, Baumgartner C, Piekorz RP, Freissmuth M,

Sexl V (2008). Leukaemic challenge unmasks a requirement of PI3Kd in NK cell degranulation.

Blood, 112, 4655-4664.

Schneider L., Essmann F., Kletke A., Rio P., Hanenberg H., Schulze-Osthoff K., Nürnberg B., Piekorz.(2008): RPTACC3 depletion sensitizes to paclitaxel-induced cell death and overrides p21WAF-mediated cell cycle arrest. Oncogene, 27: 116-25.

Cortese MM., Suschek CV., Wetzel W., Kröncke KD., Kolb-Bachofen V. (2008): Zinc protects endothelial cells from hydrogen peroxide via Nrf2-dependent stimulation of glutathione biosynthesis. Free Radic Biol Med, 44: 2002-2012.

Abstract

 

 

2007

 

van der Burgt, I., Kupsky, W., Stassou, S., Nadroo, A., Barroso, C., Diem, A., Kratz, C., Dvorsky, R., Ahmadian, M.R. and Zenker, M. Myopathy caused by HRAS germline mutations - implications on disturbed myogenic differentiation in the presence of constitutive H-Ras activation. J.Med.Genet., 44, 459-462.

Olsen, H., Herbrand, U., ter Veld, F., Ahmadian, M.R. and Wehner, F. (2007) Differential regulation of cell volume and shape in confluent rat hepatocytes under hypertonic stress. Cell. Physiol. Biochem. 19, 259-268.

Roeglin, L., Hemsath, L., Ahmadian, M.R. and Seitz, O. (2007) DNA-triggered reversible switching of peptide conformation and bioactivity. Angew. Chem. Int. Ed. Engl. 46, 2704-2707.

Gotthardt, K. and Ahmadian, M.R. (2007) Asef is a Cdc42-specific guanine nucleotide exchange factor. Biol. Chem., 388, 67-71.

Schneider L., Essmann F., Kletke A., Rio P., Hanenberg H., Schulze-Osthoff  K., Nürnberg B., Piekorz RP (2007): TACC3 depletion sensitizes to paclitaxel-induced cell death and overrides p21(WAF)-mediated cecycle arrest. Oncogene, in press, June 25.

Gohla A., Klement K., Nürnberg B. (2007): The heterotrimeric G protein G(i3) regulates hepatic autophagy downstream of the insulin receptor.  Autophagy, 3: 393-395

 Gohla A., Klement K., Piekorz R.P., Pexa  K., Vom Dahl S., Spicher K., Dreval V., Haussinger D., Birnbaumer L. and Nurnberg B. (2007): An obligatory requirement for the heterotrimeric G protein Gi3 in the antiautophagic action of  insulin in the liver. Proc. Natl. Acad. Sci. U S A, 104: 3003-3008

 Pero RS., Borchers MT., Spicher K., Ochkur SI, Sikora L., Rao SP., Abdala-Valencia H., O'neill KR., Shen H., McGarry MP., Lee NA., Cook-Mills JM., Sriramarao P., Simon MI., Birnbaumer L. and Lee JJ. (2007): G?i2-mediated signaling events in the endothelium are involved in controlling leukocyte extravasation. Proc. Natl. Acad. Sci. U S A, 104: 4371-4376

Abstract

 

 

2006

 

 

Kolb-Bachofen V., Kuhn A. and Suschek C.V. (2006): The role of nitric oxide. Rheumatology (Oxford), 45: iii17-iii19

 Wethkamp N., Ramp U., Geddert H., Schulz W.A., Florl A.R., Suschek C.V., Hassan M., Gabbert H.E. and Mahotka C. (2006): Expression of death-associated protein kinase during tumour progression of human renal cell carcinomas: hypermethylation-independent mechanisms of inactivation. Eur J Cancer, 42:264-74

Fan H., Williams D.L., Zingarelli B., Breuel K.F., Teti G., Tempel G.E., Spicher K., Boulay G., Birnbaumer L., Halushka P.V. and Cook J.A. (2006): Differential regulation of lipopolysaccharide and Gram-positive bacteria induced cytokine and chemokine production in splenocytes by Galphai proteins. Biochim Biophys Acta, 1763: 1051-1058
Abstract


Gatzka M., Piekorz R., Moriggl R., Rawlings J. and Ihle J.N. (2006): A role for STAT5A/B in protection of peripheral T-lymphocytes from postactivation apoptosis: insights from gene expression profiling. Cytokine, 34: 143-154
Abstract

Ehrhardt C., Marjuki H., Wolff T., Nürnberg B., Planz O., Pleschka S. and Ludwig S. (2006): Bivalent role of the phosphatidylinositol-3-kinase (PI3K) during influenza virus infection and host cell defence. Cell. Microbiol, 8: 1336-1348
Abstract

Cronauer M.V., InceY., Engers R., Rinnab L., Weidemann W., Suschek C.V., Burchardt M., Kleinert H., Wiedenmann J., Sies H., Ackermann R. and Kroncke K.D. (2006): Nitric oxide-mediated inhibition of androgen receptor activity: possible implications for prostate cancer progression.Oncogene,18: [Epub ahead of print]

Suschek C.V., Schewe T., Sies H. and Kroncke K.D. (2006): Nitrite, a naturally occurring precursor of nitric oxide that acts like a 'prodrug'. Biol. Chem, 387:, 499-506
Abstract

 

 

2005

 

Skokowa J., Ali S.R., Felda O., Kumar V., Konrad S., Shushakova N., Schmidt R.E., Piekorz R.P., Nürnberg B., Spicher K., Birnbaumer L., Zwirner J., Claassens J.W.C., Verbeek J.S., van Rooijen N., Köhl J., Gessner J.E. (2005): Macrophages induce the inflammatory response in the pulmonary Arthus reaction through G?i2 activation that controls C5aR and Fc receptor cooperation. Journal of Immunology, 174: 3041-3050

Piekorz R.P., Gingras S., Hoffmeyer A., Ihle JN., Weinstein Y. (2005): Regulation of progesterone levels during pregnancy and parturition by Stat5 and 20?-hydroxysteroid dehydrogenase - hydroxysteroid dehydrogenase. Molecular Endocrinology, 19: 431-440
Abstract


Voigt P., Brock C., Nürnberg B., Schaefer M. (2005): Assigning functional domains within the p101 regulatory subunit of phosphoinositide 3-kinase ?. Journal of Biological Chemistry, 280: 5121-5127
Abstract


Reppel M., Sasse P., Piekorz RP., Tang M., Roell W., Duan Y., Kletke A., Hescheler J., Nürnberg B., Fleischmann BK. (2005): S100A1 enhances the L-type Ca2+ current in embryonic mouse and neonatal rat ventricular cardiomyocytes. Journal of Biological Chemistry, doi:10.1074/jbc.M504750200.


Bo Wei., Peter Velazquez., Olga Turovskaya., Karsten Spricher., Richard Aranda., Mitchell Kronenberg., Lutz Birnbaumer and Jonathan Braun (2005): Mesenteri B cells centrally inhibit CD4+ T cell colitis through interaction with regulatory T cell subsets. Proc. Natl. Acad. Sci. U S A,  102:2010-2015  
Abstract

Cully MJ., Shiu J., Piekorz RP., Muller WJ., Done SJ., Mak TW (2005). TACC1 promotes transformation and mammary tumorigenesis. Cancer Research, 65:10363-10370

Abstract

 

 

2004

 

Kreuzer J., Nürnberg B., Krieger-Brauer H.I. (2004): Ligand-dependent autophosphorylation of the insulin receptor is positively regulated by Gi-proteins. Biochemical Journal, 380: 831-836
Abstract

Viard P., Butcher A.J., Halet G., Davies A., Nürnberg B., Heblich F., Dolphin A.C. (2004): PI3K promotes voltage-dependent calcium channel trafficking to the plasma membrane. Nature Neuroscience, 7: 93-946
Abstract

Leemhuis J., Boutillier S., Barth H., Feuerstein T., Brock C., Nürnberg B., Aktories K., Meyer D.K. (2004): Rho GTPases and phosphoinositide 3-kinase organize formation of branched dendrites. Journal of BiologicalChemistry, 279: 585-596
Abstract

Schündeln M., Piekorz R.P, Wichmann C., Lee Y., Takahashi Y., McKinnon P., Ihle J.N. (2004): The centrosomal, putative tumor suppressor TACC2 is dispensable for normal development, and deficiency does not lead to cancer. Molecular and Cellular Biology, 24: 6403-6409
Abstract

 

 

2003

 

Brock C., Schaefer M., Reusch HP., Czupalla C., Michalke M., Spicher K., Schultz G., Nürnberg B. (2003): Roles of G?? in membrane recruitment and activation of p110? /p101 phosphoinositide 3-kinase ?.

Journal of Cell Biology, 160: 89-99
Abstract

Czupalla C., Culo M., Müller E.C., Brock C., Reusch H.P., Spicher K., Krause E., Nürnberg B. (2003): Identification and characterization of the autophosphorylation sites of phosphoinositide 3-kinase isoforms ? and ?. Journal of Biological Chemistry, 278: 11536-545
Abstract

Czupalla C., Nürnberg B., Krause E. (2003): Analysis of class I phosphoinsotide 3-kinase autophosphorylation sites by mass spectrometry. Rapid Communications in Mass Spectrometry, 17: 690-696
Abstract

Pahner I., Höltje M., Winter S., Takamori S., Bellocchio E.E., Spicher K., Laake P., Nürnberg B., Ottersen O.P., Ahnert-Hilger G. (2003): Functional G-protein heterotrimers are associated with vesicles of putative glutamatergic terminals: implications for regulation of transmitter uptake. Molecular Cell Neuroscience, 23: 398-413 Corrigendum 24: 850
Abstract

Mittmann C., Pinkepank G., Stamatelopoulou S., Wieland T., Nürnberg B., Hirt S., Eschenhagen T. (2003): Differential coupling of m-cholinoceptors to Gi/Go proteins in human myocardium. Journal of Molecular and Cellular Cardiology, 35: 1241-1249
Abstract

Shelburne C.P., McCoy M.E., Piekorz R.P., Sexl V., Roh K.H., Jacobs-Helber S.M., Gillespie S.R., Bailey D.P., Gharse A., Mirmonsef P., Mann M.N., Kashyap M., Wright H.V., Chong H.J., Bouton L.A., Barnstein B., Ramirez C.D., Lantz C.S., Ryan J.J. (2003): STAT5 expression is critical for mast cell development and survival. Blood, 102: 1290-1297
Abstract

Sexl V., Kovacic B., Piekorz R.P., Moriggl R., Stoiber D., Hoffmeyer A., Weisz E., Liebminger R., Rothammer K., Ihle J.N. (2003): Jak1 deficiency leads to enhanced Abelson-induced B cell tumor formation. Blood, 101: 4937-4943
Abstract

 

 

2002

 

Breitweg-Lehmann E., Czupalla C., Storm R., Kudlacek O., Schunack W., Freissmuth M., Nürnberg B. (2002): Activation and inhibition of G proteins by lipoamines. Molecular Pharmacology, 61: 628-636

Garnham B.M., Fitzpatrick-Wong S., Schunack W., Nürnberg B., Sorrentino G., Parkinson F.E., Kanfer J.N., Sitar D.S. (2002): Activation of phospholipases A2 and D of a human neuroblastoma cell line (LA-N-2) by N-dodecyl-L-lysine amide (compound 24), a putative G protein activator: Characteristics of inhibition by (-)-nicotine. Neurochemical Research, 27 (12): 1613-618
Abstract

Pahner I., Höltje M., Winter S., Nürnberg B., Ottersen O.-P., Ahnert-Hilger G. (2002): Subunit composition and functional properties of G-protein heterotrimers on rat chromaffin granules. European Journal of Cell Biology, 81: 449-456
Abstract

Jou S.T., Carpino N., Takahashi Y., Piekorz R.P., Chao J.R., Carpino N., Wang D., Ihle J.N. (2002): An essential, non-redundant role for the phosphoinositide 3-kinase p110? in signaling by the B cell receptor complex. Molecular and Cellular Biology, 22: 8580-8591
Abstract

Shelburne C.P., Piekorz R.P., Bouton L.A., Chong H.J., Ryan J.J. (2002): Mast cells do not express a novel isoform of Stat6. Cytokine, 19: 218-227
Abstract

Piekorz R.P., Hoffmeyer A., Duntsch C.D., McKay C., Nakajima H., Sexl V., Snyder L., Rehg J., Ihle J.N. (2002): The centrosomal protein TACC3 is essential for hematopoietic stem cell function and genetically interfaces with p53 regulated apoptosis. EMBO Journal, 21: 653-664
Abstract

 

 

Fusion Protein Technologies for Biopharmaceuticals: Applications and Challenges 

 

 

Doreen M. Floss, Udo Conrad, Stefan Rose-John, and Jürgen Scheller 

ISBN-10: 0470646276

ISBN-13: 978-0470646274

Just H., Stefan E., Czupalla C., Nürnberg B., Nanoff C., Freissmuth M. (2001): Beyond G proteins: the role of accessory proteins in G protein-coupled receptor signaling. van der Goot H. (Hrsg.): Trends in Drug Research III. Elsevier Science B.V., Amsterdam, NL, S. 161-173

Nürnberg B. Monographien. Blasche W., Ebel S., Hackethal E., Holzgrabe U., Keller K., Reichling J. (Hrsg.): HagerROM 2002. Hagers Handbuch der Drogen und Arzneistoffe, update. Springer Verlag, Berlin. Heidelberg, ISBN 3-540-14908-2.

Nürnberg B., Kleuser B. Monographien. Blasche W., Ebel S., Hackethal E., Holzgrabe U., Keller K., Reichling J. (Hrsg.): HagerROM 2003. Hagers Handbuch der Drogen und Arzneistoffe, update. Springer Verlag, Berlin. Heidelberg, ISBN 3-540-14952-X

Nürnberg B. Phospholipid kinases. Offermanns S., Rosenthal W. (Hrsg.), Molecular Pharmacology, an Encyclopedic Reference. Springer Verlag, Berlin, Heidelberg, S. 739-743

Nürnberg B. Classification and functional properties of G proteins. The Nature Reviews Drug Discovery GPCR Questionnaire Participants. The Stat of GPCR Research in 2004. Nature Reviews in Drug Discovery,2004, 3:575-626

Piekorz R.P., Nürnberg B. Phospholipid kinases. Enna S.J., Bylund (Hrsg.), X-Pharm. Elsevier Inc., New York
Abstract

Nürnberg B., Piekorz R.P. Monographien. Blasche W., Ebel S., Hackethal E., Holzgrabe U., Keller K., Reichling J. (Hrsg.): HagerROM 2004. Hagers Handbuch der Drogen und Arzneistoffe, update. Springer Verlag, Berlin. Heidelberg, im Druck

Nürnberg B. Phosphoinositide 3-kinase p110 ?, class Ib catalytic subunit. Alliance for Celular Signaling (AfCS), kostenlose Registrierung erforderlich.
Abstract

Nürnberg B. Phosphoinositide 3-kinase p110?, class Ib catalytic subunit. Alliance for Celular Signaling (AfCS),kostenlose Registrierung erforderlich.
Abstract

2018


Engelowski E, Modares NF, Gorressen S, Bouvain P, Semmler D,
Alter C, Ding Z, Flögel U, Schrader J, Xu H, Lang PA, Fischer J, Floss DM, Scheller J.
IL-23R Signaling Plays No Role in Myocardial Infarction.
Sci Rep. 2018 Nov 20;8(1):17078. doi: 10.1038/s41598-018-35188-8.

Abstract



Temme S, Baran P, Bouvain P, Grapentin C, Krämer W, Knebel B, Al-Hasani H, Moll JM, Floss D, Schrader J,Schubert R, Flögel U, Scheller J.
Synthetic Cargo Internalization Receptor System for Nanoparticle Tracking of Individual Cell Populations by Fluorine Magnetic Resonance Imaging.
ACS Nano. 2018 Nov 5. doi: 10.1021/acsnano.8b05698. [Epub ahead of print]

Abstract


Madhurendra Singh, Laura Bergmann, Alexander Lang, Katja Pexa, Fabian Kuck, Dennis Stibane, Linda Janke, Hakima Ezzahoini, Antje Lindecke,
Constanze Wiek, Helmut Hanenberg, Karl Köhrer, Charlotte von Gall, Hans Reinke, and Roland P. Piekorz
Gαi3 signaling is associated with sexual dimorphic expression of the clock-controlled output gene Dbp in murine liver
Oncotarget. 2018; 9:30213-30224. doi.org/10.18632/oncotarget.25727


Abstract



Engelowski E, Schneider A, Franke M, Xu H, Clemen R, Lang A, Baran P, Binsch C,
Knebel B, Al-Hasani H,4, Moll JM1, Floß DM, Lang PA, Scheller J.
Synthetic cytokine receptors transmit biological signals using artificial ligands.
Nat Commun. 2018 May 23;9(1):2034. doi: 10.1038/s41467-018-04454-8.


Abstract



Beer-Hammer S, Lee SC, Mauriac SA, Leiss V, Groh IAM, Novakovic A, Piekorz RP, Bucher K, Chen C,
Ni K, Singer W, Harasztosi C, Schimmang T, Zimmermann U, Pfeffer K, Birnbaumer L, Forge A, Montcouquiol M, Knipper M, Nürnberg B, Rüttiger L (2018).
Gαi proteins are indispensable for hearing. Cellular Physiology and Biochemistry, in press.


Abstract


Lamertz L, Floss DM, Scheller J.
Combined deletion of the fibronectin-type III domains and the stalk region results in ligand-independent, constitutive activation of the Interleukin 6 signal-transducing receptor gp130.
Cytokine. 2018 May 19. pii: S1043-4666(18)30210-2. doi: 10.1016/j.cyto.2018.05.011. [Epub ahead of print]


Abstract



Baran P, Hansen S, Waetzig GH, Akbarzadeh M, Lamertz L, Huber HJ, Ahmadian MR,
Moll JM, Scheller J.
The balance of interleukin (IL)-6, IL-6·soluble IL-6 receptor (sIL-6R), and IL-6·sIL-6R·sgp130 complexes allows simultaneous classic and trans-signaling.
J Biol Chem. 2018 May 4;293(18):6762-6775. doi: 10.1074/jbc.RA117.001163.
Epub 2018 Mar 20.


Abstract



Behnke K, Zhuang Y, Xu HC, Sundaram B, Reich M, Shinde PV, Huang J, Modares NF,
Tumanov AV, Polz R, Scheller J, Ware CF, Pfeffer K, Keitel V, Häussinger D, Pandyra AA, Lang KS, Lang PA.
B cell-mediated maintenance of CD169+ cells is critical for liver regeneration.
Hepatology. 2018 May 9. doi: 10.1002/hep.30088. [Epub ahead of print]


Abstract
 

Alexander Lang and Roland P. Piekorz
Novel role of the SIRT4-OPA1 axis in mitochondrial quality control.
Cell Stress,Vol.2,No.1,pp.1-3; DOI:10.15698/cst2018.01.118 .


Abstract




2017


Floss DM, Schönberg M, Franke M, Horstmeier FC, Engelowski E, Schneider A, Rosenfeldt EM, Scheller J.
IL-6/IL-12 Cytokine Receptor Shuffling of Extra- and Intracellular Reveals Canonical STAT Activation via Synthetic IL-35 and IL-39 Signaling.
Sci Rep. 2017 Nov 9;7(1):15172. doi: 10.1038/s41598-017-15173-3.

Abstract

Moll JM, Wehmöller M, Frank NC, Homey L, Baran P, Garbers C, Lamertz L, Axelrod JH, Galun E,  Mootz HD, Scheller J.
Split2 Protein-Ligation Generates Active IL-6-Type Hyper-Cytokines from Inactive Precursors.
ACS Synth Biol. 2017 Nov 29. doi: 10.1021/acssynbio.7b00208. [Epub ahead of print]

Abstract

Schmok E, Abad Dar M, Behrends J, Erdmann H, Rückerl D, Endermann T,
Heitmann L, Hessmann M, Yoshimura A, Rose-John S, Scheller J, Schaible UE, Ehlers S,
Lang R, Hölscher C.
Suppressor of Cytokine Signaling 3 in Macrophages Prevents Exacerbated Interleukin-6-Dependen
t Arginase-1 Activity and Early Permissiveness to Experimental Tuberculosis.
Front Immunol. 2017 Nov 10;8:1537. doi: 10.3389/fimmu.2017.01537. eCollection 2017.

Abstract
 
Lang A, Anand R, Altinoluk-Hambüchen S, Ezzahoini H, Stefanski A, Iram A, Bergmann L,
Urbach J, Böhler P, Hänsel J, Franke M, Stühler K, Krutmann J, Scheller J, Stork B, Reichert AS, Piekorz RP.
SIRT4 interacts with OPA1 and regulates mitochondrial quality control and mitophagy.
Aging (Albany NY). 2017 Oct 29;9(10):2163-2189. doi: 10.18632/aging.101307.
 
Abstract

Bucher K, Schmitt F, Mothes B, Blumendeller C, Schäll D, Piekorz R, Hirsch E, Nürnberg B, Beer-Hammer S.
Deficiency of PI3-Kinase catalytic isoforms p110γ and p110δ in mice enhances the IL-17/G-CSF axis and induces neutrophilia.
Cell Commun Signal. 2017 Jul 19;15(1):28. doi: 10.1186/s12964-017-0185-y.

Abstract

Arnold P, Boll I, Rothaug M, Schumacher N, Schmidt F, Wichert R, Schneppenheim J, Lokau J, Pickhinke U, Koudelka T, Tholey A, Rabe B, Scheller J, Lucius R, Garbers C,
Rose-John S, Becker-Pauly C.
Meprin Metalloproteases Generate Biologically Active Soluble Interleukin-6 Receptor to Induce Trans-Signaling.
Sci Rep. 2017 Mar 9;7:44053. doi: 10.1038/srep44053.

Abstract

Hummel TM, Ackfeld T, Schönberg M, Ciupka G, Schulz F, Oberdoerster A, Grötzinger J, Scheller J, Floss DM.
Synthetic Deletion of the Interleukin 23 Receptor (IL-23R) Stalk Region Led to Autonomous IL-23R Homodimerization
and Activation.
Mol Cell Biol. 2017 Aug 11;37(17). pii: e00014-17. doi: 10.1128/MCB.00014-17. Print 2017 Sep 1.

Abstract

Ziegler V, Henninger C, Simiantonakis I, Buchholzer M, Ahmadian MR, Budach W, Fritz G.
Rho inhibition by lovastatin affects apoptosis and DSB repair of primary human lung cells in vitro and lung tissue in vivo following fractionated irradiation.
Cell Death Dis. 2017 Aug 10;8(8):e2978. doi: 10.1038/cddis.2017.372.

Abstract

Altmüller F, Pothula S, Annamneedi A, Nakhaei-Rad S, Montenegro-Venegas C, Pina-Fernández E, Marini C, Santos M, Schanze D, Montag D, Ahmadian MR, Stork O, Zenker M, Fejtova A.
Aberrant neuronal activity-induced signaling and gene expression in a mouse model of RASopathy.
PLoS Genet. 2017 Mar 27;13(3):e1006684. doi: 10.1371/journal.pgen.1006684. eCollection 2017 Mar.

Abstract

Pantaleoni F, Lev D, Cirstea IC, Motta M, Lepri FR, Bottero L, Cecchetti S, Linger I, Paolacci S, Flex E, Novelli A, Carè A, Ahmadian MR,
Aberrant HRAS transcript processing underlies a distinctive phenotype within the RASopathy clinical spectrum.
Stellacci E, Tartaglia M.
Hum Mutat. 2017 Jul;38(7):798-804. doi: 10.1002/humu.23224. Epub 2017 May 3.

Abstract

Altmüller F, Lissewski C, Bertola D, Flex E, Stark Z, Spranger S, Baynam G,
Buscarilli M, Dyack S, Gillis J, Yntema HG, Pantaleoni F, van Loon RL, MacKay S, Mina K, Schanze I, Tan TY,
Walsh M, White SM, Niewisch MR, García-Miñaúr S, Plaza D, Ahmadian MR, Cavé H, Tartaglia M, Zenker M.
Genotype and phenotype spectrum of NRAS germline variants.
Eur J Hum Genet. 2017 Jun;25(7):823-831. doi: 10.1038/ejhg.2017.65. Epub 2017 May 3.

Abstract

Nouri K, Timson DJ, Ahmadian MR.
New model for the interaction of IQGAP1 with CDC42 and RAC1.
Small GTPases. 2017 Jun 16:1-7. doi: 10.1080/21541248.2017.1321169. [Epub ahead of print]

Abstract

Hesse J, Leberling S, Boden E, Friebe D, Schmidt T, Ding Z, Dieterich P, Deussen A, Roderigo C, Rose CR, Floss DM, Scheller J, Schrader J. FASEB J.
CD73-derived adenosine and tenascin-C control cytokine production by epicardium-derived cells formed after myocardial infarction. 2017 Mar 31. pii: fj.201601307R. doi: 10.1096/fj.201601307R.. PMID: 28363952 [PubMed - as supplied by publisher]

Abstract


2016

 

Kötter S, Kazmierowska M, Andresen C, Bottermann K, Grandoch M, Gorressen S, Heinen A, Moll JM, Scheller J, Gödecke A,
Fischer JW, Schmitt JP, Krüger M.
Titin-Based Cardiac Myocyte Stiffening Contributes to Early Adaptive Ventricular Remodeling After Myocardial Infarction.
Circ Res. 2016 Oct 14;119(9):1017-1029. Epub 2016 Sep 20.

Nakhaeizadeh H, Amin E, Nakhaei-Rad S, Dvorsky R, Ahmadian MR.
The RAS-Effector Interface: Isoform-Specific Differences in the Effector Binding Regions.
PLoS One. 2016 Dec 9;11(12):e0167145. doi: 10.1371/journal.pone.0167145.

Nouri K, Fansa EK, Amin E, Dvorsky R, Gremer L, Willbold D, Schmitt L, Timson DJ, Ahmadian MR.
QGAP1 Interaction with RHO Family Proteins Revisited: KINETIC AND EQUILIBRIUM EVIDENCE FOR MULTIPLE DISTINCT BINDING SITES.
J Biol Chem. 2016 Dec 16;291(51):26364-26376.

Aden K, Breuer A, Rehman A, Geese H, Tran F, Sommer J, Waetzig GH, Reinheimer TM, Schreiber S, Rose-John S, Scheller J, Rosenstiel P
Classic IL-6R signalling is dispensable for intestinal epithelial proliferation and repair.
Oncogenesis. 2016 Nov 21;5(11):e270. doi: 10.1038/oncsis.2016.71.

Amin E, Jaiswal M, Derewenda U, Reis K, Nouri K, Koessmeier KT, Aspenström P, Somlyo AV, Dvorsky R, Ahmadian MR.
Deciphering the Molecular and Functional Basis of RHOGAP Family Proteins: A SYSTEMATIC APPROACH TOWARD SELECTIVE INACTIVATION OF RHO FAMILY PROTEINS.
J Biol Chem. 2016 Sep 23;291(39):20353-71. doi: 10.1074/jbc.M116.736967.

Nouri K, Fansa EK, Amin E, Dvorsky R, Gremer L, Willbold D, Schmitt L, Timson DJ, Ahmadian MR.
IQGAP1 interaction with RHO family proteins revisited: Kinetic and equilibrium evidence for multiple distinct binding sites.
J Biol Chem. 2016 Nov 4. pii: jbc.M116.752121. [Epub ahead of print]

Boppudi S, Bögershausen N, Hove HB, Percin EF, Aslan D, Dvorsky R, Kayhan G, Li Y, Cursiefen C, Tantcheva-Poor I, Toft PB, Bartsch O, Lissewski C, Wieland I, Jakubiczka S, Wollnik B, Ahmadian MR, Heindl LM, Zenker M
Specific mosaic KRAS mutations affecting codon 146 cause oculoectodermal syndrome and encephalocraniocutaneous lipomatosis.
Clin Genet. 2016 Oct;90(4):334-42. doi: 10.1111/cge.12775.

Galectin-1 dimers can scaffold Raf-effectors to increase H-ras nanoclustering.
Blazeevitse O, Mideksa YG, Šolman M, Ligabue A, Ariotti N, Nakhaeizadeh H, Fansa EK, Papageorgiou AC, Wittinghofer A, Ahmadian MR, Abankwa D.
Galectin-1 dimers can scaffold Raf-effectors to increase H-ras nanoclustering.
Sci Rep. 2016 Apr 18;6:24165. doi: 10.1038/srep24165.

Becker MS, Müller PM, Bajorat J, Schroeder A, Giaisi M, Amin E, Ahmadian MR, Rocks O, Köhler R, Krammer PH, Li-Weber M.
The anticancer phytochemical rocaglamide inhibits Rho GTPase activity and cancer cell migration.
Oncotarget. 2016 Jun 20. doi: 10.18632/oncotarget.10188. [Epub ahead of print]

Monhasery N, Moll J, Cuman C, Franke M, Lamertz L, Nitz R, Görg B, Häussinger D, Lokau J5, Floss DM, Piekorz R,
Dimitriadis E, Garbers C, Scheller J. Transcytosis of IL-11 and Apical Redirection of gp130 Is Mediated by IL-11? Receptor.
Cell Rep. 2016 Jul 26;16(4):1067-81. doi: 10.1016/j.celrep.2016.06.062. Epub 2016 Jul 14.

Kötter S, Kazmierowska M, Andresen C, Bottermann K, Grandoch M, Gorressen S, Heinen A, Moll J, Scheller J,
Gödecke A, Fischer JW, Schmitt JP, Krüger M. Circ Res. 2016 Sep 20. pii: CIRCRESAHA.116.309685. [Epub ahead of print]
Titin-Based Cardiac Myocyte Stiffening Contributes to Early Adaptive Ventricular
Remodeling After Myocardial Infarction. J Immunol. 2016 Oct 3. pii: 1600909. [Epub ahead of print]

Schumacher N, Schmidt S, Schwarz J, Dohr D, Lokau J, Scheller J, Garbers C,
Chalaris A, Rose-John S, Rabe B. Circulating Soluble IL-6R but Not ADAM17 Activation Drives Mononuclear
Cell Migration in Tissue Inflammation. J Immunol. 2016 Oct 3. pii: 1600909.

Abstract

Mothes B, Bucher K, Ammon-Treiber S, Schwab M, Piekorz RP, Hirsch E, Nürnberg B, Beer-Hammer S (2016).
p110g/d double deficiency induces eosinophilia and IgE production but protects from OVA-induced airway inflammation.
PLoS One, Published: July 21, 2016

Floss DM, Klöcker T, Schröder J, Lamertz L, Mrotzek S, Strobl B, Hermanns H, Scheller J. Defining the functional binding sites of Interleukin 12 receptor ?1 and Interleukin 23 receptor to Janus kinases.
Mol Biol Cell. 2016 May 18. pii: mbc.E14-12-1645.

Nitz R, Lokau J, Aparicio-Siegmund S, Scheller J, Garbers C. Modular organization of Interleukin-6 and Interleukin-11 ?-receptors.
Biochimie. 2015 Dec;119:175-82.

Geissler R, Simkin A, Floss D, Patel R, Fogarty EA, Scheller J, Grimson A. A widespread sequence-specific mRNA decay pathway mediated by hnRNPs A1 and A2/B1.
Genes Dev. 2016 May 1;30(9):1070-85.

Wolf J, Waetzig GH, Reinheimer TM, Scheller J, Rose-John S, Garbers C. A soluble form of the interleukin-6 family signal transducer gp130 is dimerized via a C-terminal disulfide bridge resulting from alternative mRNA splicing.
Biochem Biophys Res Commun. 2016 Feb 19;470(4):870-6.

Efimov GA, Kruglov AA, Khlopchatnikova ZV, Rozov FN, Mokhonov VV, Rose-John S, Scheller J, Gordon S, Stacey M, Drutskaya MS, Tillib SV, Nedospasov SA. Cell-type-restricted anti-cytokine therapy: TNF inhibition from one pathogenic source.
Proc Natl Acad Sci U S A. 2016 Mar 2. pii: 201520175.

Tsvetkov D, Shymanets A, Huang Y, Bucher K, Piekorz RP, Hirsch E, Beer-Hammer S, Harteneck C, Gollasch M, Nürnberg B (2016).
Better understanding of Phosphoinositide 3-Kinase pathways in the vasculature: Towards precision therapy targeting angiogenesis and tumor blood supply?
Biochemistry (Moscow) 2016 Jul;81(7):691-9. doi: 10.1134/S0006297916070051.

Franke M, Schröder J, Monhasery N, Ackfeld T, Hummel TM, Rabe B, Garbers C, Becker-Pauly C, Floss DM, Scheller J.
Human and murine Interleukin 23 receptors are novel substrates for a disintegrin and metalloproteases ADAM10 and ADAM17.
J Biol Chem.  2016 Mar 9. pii: jbc.M115.710541.

Lokau J, Nitz R, Agthe M, Monhasery N, Aparicio-Siegmund S, Schumacher N, Wolf J, Möller-Hackbarth K, Waetzig GH, Grötzinger J, Müller-Newen G, Rose-John S, Scheller J, Garbers C. Proteolytic Cleavage Governs Interleukin-11 Trans-signaling.
Cell Rep. 2016 Feb 23;14(7):1761-73. 

Nakhaei-Rad S, Nakhaeizadeh H, Götze S, Kordes C, Sawitza I, Hoffmann MJ, Franke M, Schulz WA, Scheller J, Piekorz RP, Häussinger D, Ahmadian MR. The role of embryonic stem cell-expressed RAS (ERAS) in the maintenance of quiescent hepatic stellate cells.
J Biol Chem. 2016 Feb 16. pii: jbc.M115.700088.

Sohn D, Peters D, Piekorz RP, Budach W, Jänicke RU (2016). miR-30e controls DNA damage-induced stress responses by modulating expression of the CDK inhibitor p21WAF1/CIP1 and caspase-3. Oncotarget,
Oncotarget. 2016 Mar 29;7(13):15915-29. doi: 10.18632/oncotarget.7432.

Lang A, Grether-Beck S, Singh M, Kuck F, Jakob S, Kefalas A, Altinoluk-Hambüchen S, Graffmann N, Schneider M, Lindecke A, Brenden H, Felsner I, Ezzahoini H,  Marini A, Weinhold S, Vierkötter A, Tigges J, Schmidt S, Stühler K, Köhrer K, Uhrberg M, Haendeler J, Krutmann J, Piekorz RP. MicroRNA-15b regulates mitochondrial ROS production and the senescence-associated secretory phenotype through sirtuin 4/SIRT4. Aging (US) 2016

Abstract

2015

 

Chronophin is a glial tumor modifier involved in the regulation of glioblastoma growth and invasiveness.
Schulze M, Fedorchenko O, Zink TG, Knobbe-Thomsen CB, Kraus S, Schwinn S, Beilhack A, Reifenberger G, Monoranu CM, Sirén AL, Jeanclos E, Gohla A.
Oncogene. 2015 Nov 9. doi: 10.1038/onc.2015.376.


Anti-interleukin-6 therapy through application of a monogenic protein inhibitor via gene delivery.
Görtz D, Braun GS, Maruta Y, Djudjaj S, van Roeyen CR, Martin IV, Küster A, Schmitz-Van de Leur H, Scheller J, Ostendorf T, Floege J, Müller-Newen G.  
Sci Rep. 2015 Oct 1;5:14685. doi: 10.1038/srep14685

Lacroix M, Rousseau F, Guilhot F, Malinge P, Magistrelli G, Herren S,Jones SA, Jones GW, Scheller J, Lissilaa R, Kosco-Vilbois M, Johnson Z, Buatois V, Ferlin W.
Novel insights into IL-6 cis- and trans-signaling pathways by differentially manipulating the assembly of the IL-6 signaling complex.
J Biol Chem. 2015 Sep 11. pii: jbc.M115.682138.

Floss, D., Schröder, J., Franke, M. & Scheller, J. (2015) Insights into IL-23 biology: From structure to function, Cytokine Growth Factor Rev. 2015 Jul 11. pii: S1359-6101(15)00053-2.

 Rose-John, S., Scheller, J. & Schaper, F. (2015) "Family reunion"
- A structured view on the composition of the receptor complexes of interleukin-6-type and
interleukin-12-type cytokines, Cytokine Growth Factor Rev. 2015 Jul 6. pii: S1359-6101(15)-3.

Oyanedel CN, Kelemen E, Scheller J, Born J, Rose-John S.
Peripheral and central blockade of interleukin-6 trans-signaling differentially affects sleep architecture Brain Behav Immun. 2015 Jul 2. pii: S0889-1591(15)00235-4.

Nakhaei-Rad S1, Nakhaeizadeh H1, Kordes C2, Cirstea IC3, Schmick M4, Dvorsky R1, Bastiaens PI4, Häussinger D2, Ahmadian MR5.he Function of Embryonic Stem Cell-expressed RAS (E-RAS), a Unique RAS Family Member, Correlates with Its Additional Motifs and Its Structural Properties.
J Biol Chem. 2015 Jun 19;290(25):15892-903.

Vasudharani Devanathan, Ina Hagedorn, David Köhler, Katja Pexa, Deya
Cherpokova, Peter Kraft, Madhurendra Singh, Peter Rosenberger, Guido Stolle, Lutz
Birnbaumer, Roland Piekorz, Sandra Beer-Hammer, Bernhard Nieswandt, Bernd Nürnberg
Platelet G?i2 is an essential mediator of thrombo-inflammatory organ damage in mice.
Proc Natl Acad Sci U S A. 2015 May 19;112(20):6491-6. 

Schröder J, Moll JM, Baran P, Grötzinger J, Scheller J, Floss DM.
Non-canonical Interleukin 23 receptor complex assembly: p40 recruits Interleukin 12 Receptor beta 1 via site II and induces p19/Interleukin 23 Receptor interaction via site III.
J Biol Chem.  2015 Jan 2;290(1):359-70.

Abstract

 

2014

 

Müller J, Gorressen S, Grandoch M, Feldmann K, Kretschmer I, Lehr S, Ding Z, Schmitt JP, Schrader J, Garbers C, Heusch G, Kelm M, Scheller J, Fischer JW.
Interleukin-6-dependent phenotypic modulation of cardiac fibroblasts after acute myocardial infarction.
Basic Res Cardiol. 2014 ;109(6):440.

Karbach S, Croxford AL, Oelze M, Schüler R, Minwegen D, Wegner-Kops J, Koukes L, Yogev N, Nikolaev A, Reißig S, Ullmann A, Knorr M, Waldner M, Neurath M, Li H, Wu Z, Brochhausen C, Scheller J, Rose-John S, Piotrowski C, Bechmann I, Radsak M, Wild P, DaiberA, von Stebut E, Wenzel P, Waisman A, Münzel T.
Interleukin 17 Drives Vascular Inflammation, Endothelial Dysfunction, and Arterial Hypertension in Psoriasis-Like Skin Disease.
Arterioscler Thromb Vasc Biol. 2014 34(12):2658-68.

Aparicio-Siegmund S, Moll JM, Lokau J, Grusdat M, Schröder J, Plöhn S, Rose-John S, Grötzinger J, Lang PA, Scheller J, Garbers C.  
Recombinant p35 from Bacteria Can Form Interleukin (IL-)12, but Not IL-35.
PLoS One. 2014  26;9(9):e107990 .

Schönberger T, Jürgens T, Müller J, Armbruster N, Niermann C, Gorressen S, Sommer J, Tian H, di Paolo G, Scheller J, Fischer JW, Gawaz M, Elvers M.
Pivotal Role of Phospholipase D1 in Tumor Necrosis Factor-?-Mediated Inflammation and Scar Formation after Myocardial Ischemia and Reperfusion in Mice.
Am J Pathol. 2014  184(9):2450-64.

Marczynska J, Ozga A, Wlodarczyk A, Majchrzak-Gorecka M, Kulig P, Banas M, Michalczyk-Wetula D, Majewski P, Hutloff A, Schwarz J, Chalaris A, Scheller J, Rose-John S, Cichy J. The Role of Metalloproteinase ADAM17 in Regulating ICOS Ligand-Mediated Humoral Immune Responses.
J Immunol. 2014  15;193(6):2753-63.

Sommer J, Engelowski E, Baran P, Garbers C, Floss DM, Scheller J.
Interleukin-6, but not the interleukin-6 receptor plays a role in recovery from dextran sodium sulfate-induced colitis.
Int J Mol Med. 2014  34(3):651-60.

Sommer J, Garbers C, Wolf J, Trad A, Moll JM, Sack M, Fischer R, Grötzinger J, Waetzig GH, Floss DM, Scheller.
Alternative intronic polyadenylation generates the interleukin-6 trans-signaling inhibitor SGP130-E10.
J Biol Chem. 2014  8;289(32):22140-50. 

Garbers C1, Monhasery N2, Aparicio-Siegmund S2, Lokau J3, Baran P2, Nowell MA4, Jones SA4, Rose-John S3, Scheller J.
The Interleukin-6 Receptor Asp358Ala Single Nucleotide Polymorphism rs2228145 Confers Increased Proteolytic Conversion Rates by ADAM Proteases.
Biochim Biophys Acta. 2014 1842(9):1485-94.

Wagener EM, Aurich M, Aparicio-Siegmund S, Floss DM, Garbers C, Breusing K, Rabe B, Schwanbeck R, Grötzinger J, Rose-John S, Scheller J.
The amino acid exchange R28E in ciliary neurotrophic factor (CNTF) abrogates IL-6R- but retains CNTFR-dependent signaling via gp130/LIFR.
J Biol Chem. 2014   289(26):18442-50.

Düsterhöft S, Höbel K, Oldefest M, Lokau J, Waetzig GH, Chalaris A, Garbers C, Scheller J, Rose-John S, Lorenzen I, Grötzinger J.
"A Disintegrin And Metalloprotease-17 Dynamic interaction sequence" (CANDIS) - the sweet tooth for the human interleukin 6receptor.
J Biol Chem. 2014  6;289(23):16336-48.

Dewitz C1, Möller-Hackbarth K, Schweigert O, Reiss K, Chalaris A, Scheller J, Rose-John S.
T-cell immunoglobulin and mucin domain 2 (TIM-2) is a target of ADAM10-mediated ectodomain shedding.
FEBS J. 2014 281(1):157-74.

Flex E1, Jaiswal M, Pantaleoni F, Martinelli S, Strullu M, Fansa EK, Caye A, De Luca A, Lepri F, Dvorsky R, Pannone L, Paolacci S, Zhang SC, Fodale V, Bocchinfuso G, Rossi C, Burkitt-Wright EM, Farrotti A, Stellacci E, Cecchetti S, Ferese R, Bottero L, Castro S, Fenneteau O, Brethon B, Sanchez M, Roberts AE, Yntema HG, Van Der Burgt I, Cianci P, Bondeson ML, Cristina Digilio M, Zampino G, Kerr B, Aoki Y, Loh ML, Palleschi A, Di Schiavi E, Carè A, Selicorni A, Dallapiccola B, Cirstea IC, Stella L, Zenker M, Gelb BD, Cavé H, Ahmadian MR, Tartaglia M.
Activating mutations in RRAS underlie a phenotype within the RASopathy spectrum and contribute to leukaemogenesis.Hum Mol Genet. 2014  15;23(16):4315-27. 

Jaiswal M1, Dvorsky R, Amin E, Risse SL, Fansa EK, Zhang SC, Taha MS, Gauhar AR, Nakhaei-Rad S, Kordes C, Koessmeier KT, Cirstea IC, Olayioye MA, Häussinger D, Ahmadian MR.
Functional crosstalk between Ras and Rho pathways: p120RasGAP competitively inhibits the RhoGAP activity of Deleted in Liver Cancer (DLC) tumor suppressors by masking its catalytic arginine finger.
J Biol Chem. 2014  7;289(10):6839-49.

Croxford AL, Karbach S, Kurschus FC, Wörtge S, Nikolaev A, Yogev N, Klebow S, Schüler R, Reissig S, Piotrowski C, Brylla E, Bechmann I, Scheller J, Rose-John S, Wunderlich FT, Münzel T, von Stebut E, Waisman A.
IL-6 Regulates Neutrophil Microabscess Formation in IL-17A-Driven Psoriasiform Lesions.
Journal of Investigative Dermatology (2014) 134, 728–735.

Krieg, A.Mersch, S.Boeck, I.Dizdar, L.Weihe, E.Hilal, Z.Krausch, M.Mohlendick, B.Topp, S. A.Piekorz, R. P.Huckenbeck, W.Stoecklein, N. H.Anlauf, M.Knoefel, W. T.
New Model for Gastroenteropancreatic Large-Cell Neuroendocrine Carcinoma: Establishment of Two Clinically Relevant Cell Lines.
PLoS One. 2014 14;9(2):e88713. 

Olga Schweigerta,Christin Dewitza,Katja Möller-Hackbartha,Ahmad TradaChristoph Garbersb,Stefan Rose-Johna,Jürgen Scheller, Soluble T cell immunoglobulin and mucin domain (TIM)-1 and -4 generated by A Disintegrin And Metalloprotease (ADAM)-10 and -17 bind to phosphatidylserine.
Biochim Biophys Acta. 2014 1843(2):275-87.

Mohamed S. Taha,Kazem Nouri,Lech G. Milroy, Jens M. Moll,Christian Herrmann, Luc Brunsveld, Roland P. Piekorz, Mohammad R. Ahmadian.
Subcellular Fractionation and Localization Studies Reveal a Direct Interaction of the Fragile X Mental Retardation Protein (FMRP) with Nucleolin.
PLoS One. 2014  21;9(3):e91465.

Thakur HC1, Singh M, Nagel-Steger L, Kremer J, Prumbaum D, Fansa EK, Ezzahoini H, Nouri K, Gremer L, Abts A, Schmitt L, Raunser S, Ahmadian MR, Piekorz RP.
The centrosomal adaptor TACC3 and the microtubule polymerase chTOG interact via defined C-terminal subdomains in an Aurora-A kinase-independent manner.
J Biol Chem. 2014  3;289(1):74-88.

Trilling M1, Le VT, Rashidi-Alavijeh J, Katschinski B, Scheller J, Rose-John S, Androsiac GE, Jonjic S, Poli V, Pfeffer K, Hengel H.
"Activated" STAT proteins: a paradoxical consequence of inhibited JAK-STAT signaling in cytomegalovirus-infected cells.
J. Virol.  2014  23 13638-13650 .

Abe M, Yuki Y, Kurokawa S, Mejima M, Kuroda M, Park EJ, Scheller J, Nakanishi U, Kiyono H.
A rice-based soluble form of a murine TNF-specific llama variable domain of heavy-chain antibody suppresses collagen-induced arthritis in mice.
J Biotechnol. 2014 168-1656(14)00078-9.

Campbell IL, Erta M, Lim SL, Frausto R, May U, Rose-John S, Scheller J, Hidalgo J.
Trans-signaling is a dominant mechanism for the pathogenic actions of interleukin-6 in the brain.
J Neurosci. 2014 12;34(7):2503-13.

Abstract

 

2013

 

Scheller J, Garbers C, Rose-John S.
Interleukin-6: From basic biology to selective blockade of pro-inflammatory activities.
Semin Immunol. 2013 1044-5323(13)00119.

Mayer S, Kumar R, Jaiswal M, Soykan T, Ahmadian MR, Brose N, Betz H, Rhee JS,
Papadopoulos T. Collybistin activation by GTP-TC10 enhances postsynaptic gephyrin
clustering and hippocampal GABAergic neurotransmission.
Proc Natl Acad Sci U S A 2013 17;110(51):20795-800.

Rho-kinase: regulation, (dys)function, and inhibition.
Amin E, Dubey BN, Zhang SC, Gremer L, Dvorsky R, Moll JM, Taha MS, Nagel-Steger L, Piekorz RP, Somlyo AV, Ahmadian MR.
Rho-kinase: regulation, (dys)function, and inhibition.
Biol Chem. 2013  1;394(11):1399-410. 

Cirstea IC, Gremer L, Dvorsky R, Zhang SC, Piekorz RP, Zenker M, Ahmadian MR. .
Diverging gain-of-function mechanisms of two novel KRAS mutations associated with Noonan and cardio-facio-cutaneous syndromes. Hum Mol Genet.
Epub 2013 15;22(2):262-70. 

Interaction characteristics of Plexin-B1 with Rho family proteins.
Fansa EK, Dvorsky R, Zhang SC, Fiegen D, Ahmadian MR.Biochem Biophys Res Commun.
Interaction characteristics of Plexin-B1 with Rho family proteins
Epub 2013 17;434(4):785-90.



Risse SL, Vaz B, Burton MF, Aspenström P, Piekorz RP, Brunsveld L, Ahmadian MR.
SH3-mediated targeting of Wrch1/RhoU by multiple adaptor proteins.
Biol Chem. 2013 394(3):421-32.


Jaiswal M, Fansa EK, Dvorsky R, Ahmadian MR.
New insight into the molecular switch mechanism of human Rho family proteins: shifting a paradigm.
Biol Chem. 2013 394(1):89-95. 

Schweigert O, Dewitz C, Möller-Hackbarth K, Trad A, Garbers C, Rose-John S, Scheller J.
Soluble T cell immunoglobulin and mucin domain (TIM-) 1 and 4 generated by A Disintegrin And Metalloproteases (ADAM-)10 and 17 bind to phosphatidylserine.
Biochim Biophys Acta. 2013  167-4889(13)00406-0. 

Möller-Hackbarth K, Dewitz C, Schweigert O, Trad A, Garbers C, Rose-John S, Scheller J.
ADAM10 AND ADAM17 are major sheddases of T cell immunoglobulin and mucin domain 3 (TIM-3).
J Biol Chem. 2013 288(48):34529-44.

Croxford AL, Karbach S, Kurschus FC, Wörtge S, Nikolaev A, Yogev N, Klebow S, Schüler R, Reissig S,
Piotrowski C, Brylla E, Bechmann I, Scheller J, Rose-John S, Wunderlich FT, Münzel T, von Stebut E,
Waisman A.
IL-6 Regulates Neutrophil Microabscess Formation in IL-17A-Driven Psoriasiform Lesions.
J Invest Dermatol. 2014 134(3):728-35.



Garbers C, Kuck F, Aparicio-Siegmund S, Konzak K, Kessenbrock M, Sommerfeld A, Häussinger D,
Lang PA, Brenner D, Mak TW, Rose-John S, Essmann F, Schulze-Osthoff K, Piekorz RP, Scheller J.
Cellular senescence or EGFR signaling induces Interleukin 6 (IL-6) receptor expression controlled by mammalian target of rapamycin (mTOR).
Cell Cycle. 2013 1;12(21):3421-32

  

Thakur HC, Singh M, Nagel-Steger L, Prumbaum D, Kalawy Fansa E, Gremer L, Ezzahoini H, Abts A, Schmitt L, Raunser S, Ahmadian MR, Piekorz RP.
Role of centrosomal adaptor proteins of the TACC family in the regulation of microtubule dynamics during mitotic cell division.
Biol Chem. 2013  394(11):1411-23. 



Braun O, Dewitz C, Möller-Hackbarth K, Scheller J, Schiffelholz T, Baier PC, Rose-John S.
Effects of blockade of peripheral interleukin-6 trans-signaling on hippocampus-dependent and independent memory in mice.
J Interferon Cytokine Res.
J Interferon Cytokine Res. 2013  33(5):254-60. 



Spehlmann ME, Manthey CF, Dann SM, Hanson E, Sandhu SS, Liu LY, Abdelmalak FK, Diamanti MA, Retzlaff K, Scheller J, Rose-John S, Greten FR, Wang JY, Eckmann L.
Trp53 Deficiency Protects against Acute Intestinal Inflammation.
J Immunol. 2013  15;191(2):837-47



Judith Hoge, Isabell Yan, Nathalie Janner, Valea Schumacher, Athena Chalaris, Oliver M. Steinmetz, Daniel R. Engel, Jurgen Scheller, Stefan Rose-John, and Hans-Willi Mittrucker
IL-6 Controls the Innate Immune Response against Listeria monocytogenes via Classical IL-6 Signaling
J Immunol. 2013  15;190(2):703-11

Christoph Garbers, Bjorn Spudy, Samadhi Aparicio-Siegmund, Georg H. Waetzig, Jan Sommer, Christoph Holscher, Stefan Rose-John, Joachim Grotzinger, Inken Lorenzen, and Jürgen Scheller
An interleukin -6 receptor-dependent molecular switch mediates signal transduction of the IL-27 cytokine subunit p28 (IL-30) via a gp130 receptor homodimer.
J Biol Chem. 2013  8;288(6):4346-54

Garbers C, Scheller J.
Interleukin-6 and interleukin-11: same same but different.
Biol Chem. 2013  394(9):1145-61

Doreen M. Floss, Simone Mrotzek, Tobias Klöcker, Jutta Schröder, Joachim Grözinger, Stefan Rose-John, and Jürgen Scheller
Identification of canonical tyrosine-dependent and non-canonical tyrosine-independent STAT3 activation sites in the intracellular domain of the interleukin 23 receptor.
J Biol Chem. 2013  5;288(27):19386-400.

Baran P, Nitz R, Grötzinger J, Scheller J, Garbers C.
Minimal interleukin (IL-)6 receptor stalk composition for IL-6R shedding
and IL-6 classic signaling.
J Biol Chem. 2013  24;288(21):14756-68.

Abstract

Phan HT, Pohl J, Floss DM, Rabenstein F, Veits J, Le BT, Chu HH, Hause G, Mettenleiter T, Conrad U.
ELPylated haemagglutinins produced in tobacco plants induce potentially neutralizing
antibodies against H5N1 viruses in mice.
Plant Biotechnol J. 2013 11(5):582-93.


Risse SL; Vaz B, Burton M, Aspenström P, Piekorz RP, Brunsveld L, Ahmadian MR (2013).
SH3-mediated targeting of Wrch1/RhoU by multiple adaptor proteins. Biol. Chem., 394, 421-432.
Biol Chem. 2013 394(3):421-32. 

Luca AC, Deenen R, Mersch S, Schmidt S, Messner I, Schäfer KL, Baldus SE, Huckenbeck W, Piekorz RP, Knoefel WT, Krieg A, Stoecklein NH.
Impact of the 3D microenvironment on phenotype, gene expression,
and EGFR inhibition of colorectal cancer cell lines.
PLoS One,  2013  8(3):e59689



Pietkiewicz S, Sohn D, Piekorz RP, Grether-Beck S, Budach W, Sabapathy K,
Jänicke RU.
Oppositional regulation of Noxa by Jnk1 and Jnk2 during apoptosis induced by proteasomal
inhibitors.
PLoS One, 2013 8(4):e61438

Jaiswal M, Kalawy Fansa E, Dvorsky R, Ahmadian R.
New insight into the molecular switch mechanism of human Rho family proteins: shifting a paradigm.
Biol Chem. 2013  394(3):421-32.


Jaiswal M, Dvorsky R, Ahmadian MR.
Deciphering the molecular and functional basis of Dbl family proteins: A novel systematic
approach towards classification of selective activation of the Rho family proteins.
J Biol Chem. 2013  8;288(6):4486-500.

Abstract

 

Risse SL, Vaz B, Burton MF, Aspenström P, Piekorz RP, Brunsveld L, Ahmadian MR.
SH3-mediated targeting of Wrch1/RhoU by multiple adaptor proteins.
Biol Chem. 2013 394(3):421-32.

Valeska Hauptmann, Nicola Weichert, Matthias Menzel, Dominic Knoch, Norman Paege, Jürgen Scheller, Uwe Spohn, Udo Conrad und Mario Gils.
Native-sized spider silk proteins synthesized in planta via intein-based
multimerization.
Transgenic Res. 2013 22(2):369-77.


Abstract


 

2012




Recombinant IL-6 treatment protects mice from organ specific autoimmune
disease by IL-6 classical signalling-dependent IL-1ra induction.
Samavedam UK, Kalies K, Scheller J, Sadeghi H, Gupta Y, Jonkman MF, Schmidt E, Westermann J, Zillikens D, Rose-John S, Ludwig RJ.
J Autoimmun. 2013 40:74-85. 

Scheller J, Rose-John S.
The interleukin 6 pathway and atherosclerosis.
Lancet. 2012  28;380(9839):338.

Abstract

Garbers C, Hermanns HM, Schaper F, Müller-Newen G, Grötzinger J, Rose-John S, Scheller J.
Plasticity and cross-talk of Interleukin 6-type cytokines.
Cytokine Growth Factor Rev. 2012 23(3):85-97.



I Lorenzen, J Lokau, S Dusterhoft, A Trad, C Garbers, J Scheller, S Rose-John, and J Grotzinger
The membrane-proximal domain of A Disintegrin and Metalloprotease 17
(ADAM17) is responsible for recognition of the interleukin-6 receptorand interleukin-1 receptor II.
FEBS Lett 24  2012 586(8): p. 1093

M Schaab, H Kausch, J  Klammt, M  Nowicki, U  Anderegg, R  Gebhardt,
S  Rose-John, J  Scheller, J  Thiery, J  Kratzsch
Novel Regulatory Mechanisms for Generation of the Soluble Leptin Receptor: Implications for Leptin Action
PLos ONE   2012  7(4):e34787.


Yamamoto K, Trad A, Baumgart A, Hüske L, Lorenzen I, Chalaris A, Grötzinger J, Dechow T, Scheller J, Rose-John S. A novel bispecific single-chain antibody for ADAM17 and CD3 induces T-cell mediated lysis of prostate cancer cells.
Biochem J. 2012  1;445(1):135-44.



Suthaus J, Stuhlmann-Laeisz C, Tompkins VS, Rosean TR, Klapper W, Tosato
G, Janz S, Scheller J, Rose-John S.HHV8 encoded viral IL-6 collaborates with mouse IL-6 in MCD-like
development in mice.
Blood. 2012 31;119(22):5173-81. 



Sommer J, Effenberger T, Volpi E, Waetzig GH, Bernhardt M, Suthaus J, Garbers C, Rose-John S, Floss DM, Scheller J.Constitutively active mutant GP130 receptor protein from inflammatory hepatocellular adenoma is inhibited by an anti-GP130 antibody which specifically neutralize
IL-11-signaling.
J Biol Chem. 2012  20;287(17):13743-51. 



Sodenkamp J, Waetzig GH, Scheller J, Seegert D, Grötzinger J, Rose-John
S, Ehlers S, Hölscher C. Therapeutic targeting of interleukin-6
trans-signaling does not affect the outcome of experimental
tuberculosis. Immunobiology. 2012 Jan 20. [Epub ahead of print]


Abstract


The p101 subunit of PI3K? restores activation by Gß mutants deficient in stimulating p110?.
Shymanets A, Ahmadian MR, Kössmeier KT, Wetzker R, Harteneck C, Nürnberg B.
The p101 subunit of PI3K? restores activation by Gß mutants deficient in stimulating p110?.
Biochem J. 2012 Feb 1;441(3):851-8.



Jaiswal M, Dubey BN, Koessmeier KT, Gremer L, Ahmadian MR. Biochemical assays to characterize Rho GTPases.
Methods Mol Biol. 2012;827:37-58. PMID: 22144266


Abstract



Marieke A. M. Frasa, Katja T. Koessmeier, M. Reza Ahmadian & Vania M. M. Braga (2012) Illuminating the functional and structural repertoire of human TBC/RABGAPs. Nature Reviews Molecular Cell Biology, advance online publication, Published online 18 January 2012 | doi:10.1038/nrm3267



Putz EM, Prchal M, Simma OA, Forster F, Koenig X, Stockinger H, Piekorz RP, Freissmuth M,
Müller M, Sexl V, Zebedin E (2012). PI3K? is essential for tumor clearance mediated by
cytotoxic T lymphocytes. PLoS One, in press. 

 

Wiege K, Ali SR, Gewecke B, Novakovic A, Konrad FM, Pexa K, Beer-Hammer S, Reutershan J, Piekorz RP, Schmidt RE, Nürnberg B, Gessner JE (2012). G?i2 is the essential G?i protein in immune complex-induced lung disease. J. Immunol., in press.


Cirstea IC, Gremer L, Dvorsky R, Zhang S-C, Piekorz RP, Zenker M, Ahmadian MR (2012). Diverging gain-of-function mechanisms of two novel KRAS mutations associated with Noonan and Cardio-Facio-Cutaneous syndromes. Hum. Mol. Genet., doi:10.1093/hmg/dds426

 

Wiege K, Le DD, Seyd SN, Ali SR, Novakovic A, Beer-Hammer S, Piekorz RP, Schmidt RE, Nürnberg B, Gessner JE (2012). Defective macrophage migration in G?i2- but not G?i3-deficient mice. J. Immunol., 189, 980-987.

Abstracht

 

 

2011



Scheller, J., Chalaris, A., Garbers, C., and Rose-John, S. 2011. :  ADAM17: a molecular switch to control inflammation and tissue regeneration. Trends Immunol 32 (8): 380-7.

 

Scheller, J., Chalaris, A., Schmidt-Arras, D., and Rose-John, S. 2011. The pro- and anti-inflammatory properties of the Cytokine Interleukin-6. Biochim Biophys Acta - Mol Cell Res 1813:878-888.

 

Kushnir S, Cirstea IC, Basiliya L, Lupilova N, Breitling R, Alexandrov K. Artificial linear episome-based protein expression system for protozoon Leishmania tarentolae. Mol Biochem Parasitol. 2011 Apr;176(2):69-79. PMID: 21167214



Stark Z, Gillessen-Kaesbach G, Ryan MM,Cirstea IC, Gremer L, Ahmadian MR, Savarirayan R, Zenker M. Two novel germline KRAS mutations: expanding the molecular and clinical phenotype.
Clin Genet. 2011 Jul 28.   PMID: 21797849

 


Kraft M,Cirstea IC, Voss AK, Thomas T, Goehring I, Sheikh BN, Gordon L, ScottH,  Smyth GK, Ahmadian MR, Trautmann U, Zenker M, Tartaglia M, Ekici A, Reis A, Dörr HG, Rauch A, Thiel CT.Kraft M: Disruption of the histone acetyltransferase MYST4 leads to a Noonan syndrome-like phenotype and hyperactivated MAPK signaling in humans and mice.


Abstract

 

Gremer L: Germline KRAS mutations cause aberrant biochemical and physical properties leading to developmental disorders.


Abstract

 

Ismail SA: Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo.

Abstract


Scholz RP: The tumor suppressor protein DLC1 is regulated by PKD-mediated GAP domain phosphorylation.

 

Malchow, S., Thaiss, W., Jänner, N., Waetzig, G.H., Gewiese-Rabsch, J., Garbers, C., Yamamoto, K., Rose-John, S., and Scheller, J. 2011. Essential role of neutrophil mobilization in concanavalin A-induced hepatitis is based on classic IL-6 signaling but not on IL-6 trans-signaling. Biochim Biophys Acta 1812:290-301.

 

Jones SA: Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling.

Abstract


Conrad U: ELPylated anti-human TNF therapeutic single-domain antibodies for prevention of lethal septic shock.

 

Scheller, J., Chalaris, A., Schmidt-Arras, D., and Rose-John, S. 2011. The pro- and anti-inflammatory properties of the Cytokine Interleukin-6. Biochim Biophys Acta - Mol Cell Res 1813:878-888.

 

Kruglov, A.A., Tumanov, A.V., Grivennikov, S.I., Shebzukhov, Y.V., Kuchmiy, A.A., Efimov, G.A., Drutskaya, M.S., Scheller, J., Kuprash, D.V., and Nedospasov, S.A. 2011. Modalities of Experimental TNF Blockade In Vivo: Mouse Models. Adv Exp Med Biol 691:421-431.

Abstract

 

Garbers, C., Jänner, N., Chalaris, A., Moss, M.L., Floss, D.M., Meyer, D., Koch-Nolte, F., Rose-John, S., and Scheller, J. 2011. Species specificity of ADAM10 and ADAM7 in IL-6 transsignaling and novel role of ADAM10 in inducible IL-6R shedding. J Biol Chem [Epub ahead of print].

Abstract


Chalaris, A., Garbers, C., Rabe, B., Rose-John, S., and Scheller, J. 2011. The soluble Interleukin 6 receptor: Generation and role in inflammation and cancer. Eur J Cell Biol Epub ahead of print doi:10.1016/j.ejcb.2010.10.007.


Barkhausen, T., Tschernig, T., Rosenstiel, P., van Griensven, M., Vonberg, R.P., Dorsch, M., Mueller-Heine, A., Chalaris, A., Scheller, J., Rose-John, S., et al. 2011. Selective blockade of interleukin-6 trans-signaling improves survival in a murine polymicrobial sepsis model. Crit Care Med Epub ahead of print.

Abstract


Dizayee S, Kaestner S, Kuck F, Hein P, Klein C, Piekorz RP, Meszaros J, Matthes J, Nürnberg B, Herzig S. Gai2- and Gai3-specific regulation of voltage-dependent L-type calcium channels in cardiomyoctes. PLoS One, in press.


Luk SK, Piekorz RP, Nürnberg B, To SST. The catalytic phosphoinositol 3-kinase p110d is required for glioma cell migration and invasion. Eur. J. Cancer, in press.

Jaiswal M: Mechanistic insights into specificity, activity, and regulatory elements of the regulator of G-protein signaling (RGS)-containing Rho-specific guanine nucleotide exchange factors (GEFs) p115, PDZ-RhoGEF (PRG), and leukemia-associated RhoGEF (LARG).

von Holleben M: The immunoinhibitory adapter protein SRC homology domain 3 lymphocyte protein 2 (SLy2) regulates actin dynamics and B cell spreading.

Abstract

 

 

2010



Schmidt S, Essmann F, Cirstea IC, Kuck F, Thakur HC, Singh M, Kletke A, Jänicke RU, Wiek C, Hanenberg H, Ahmadian MR, Schulze-Osthoff K, Nürnberg B, Piekorz RP. The centrosome and mitotic spindle apparatus in cancer and senescence. Cell Cycle. 2010 Nov 20;9(22). [Epub ahead of print]

Scholz RP, Gustafsson JO, Hoffmann P, Jaiswal M, Ahmadian MR, Eisler S, Erlmann P, Schmid S, Hausser A, Olayioye MA. The tumor suppressor protein DLC1 is regulated by PKD-mediated GAP domain phosphorylation. Exp Cell Res. 2010 Nov 15. [Epub ahead of print]

Schmidt S, Schneider L, Essmann F, Cirstea IC, Kuck F, Kletke A, Jänicke RU, Wiek C, Hanenberg H, Ahmadian MR, Schulze-Osthoff K, Nürnberg B, Piekorz RP. The centrosomal protein TACC3 controls paclitaxel sensitivity by modulating a premature senescence program. Oncogene. 2010 Aug 23. [Epub ahead of print]

Lothar Gremer*, Torsten Merbitz-Zahradnik*, Radovan Dvorsky*, Ion C. Cirstea*, Christian Peter Kratz, Martin Zenker, Alfred Wittinghofer, Mohammad Reza Ahmadian. Germline KRAS mutations cause aberrant biochemical and physical properties leading to developmental disorders. Hum Mutat. 2010 Oct 14. [Epub ahead of print]. *, equal contribution.

Cirstea IC, Kutsche K, Dvorsky R, Gremer L, Carta C, Horn D, Roberts AE, Lepri F, Merbitz-Zahradnik T, König R, Kratz CP, Pantaleoni F, Dentici ML, Joshi VA, Kucherlapati RS, Mazzanti L, Mundlos S, Patton MA, Silengo MC, Rossi C, Zampino G, Digilio C, Stuppia L, Seemanova E, Pennacchio LA, Gelb BD, Dallapiccola B, Wittinghofer A, Ahmadian MR, Tartaglia M, Zenker M. A restricted spectrum of NRAS mutations causes

Noonan syndrome. Nat Genet. 2010 Jan;42(1):27-9.

Gremer L, De Luca A, Merbitz-Zahradnik T, Dallapiccola B, Morlot S, Tartaglia M, Kutsche K, Ahmadian MR, Rosenberger G. Duplication of Glu37 in the switch I region of HRAS impairs effector/GAP binding and underlies Costello syndrome by promoting enhanced growth factor-dependent MAPK and AKT activation. Hum Mol

Genet. 2010 Mar 1;19(5):790-802.

Gomez-Baldo L, Schmidt S, Maxwell CA, Bonifaci N, Gabaldon T, Vidalain PO, Senepedis W, Kletke A, Rosing M, Barnekow A, Rottapel R, Capella G, Vidal M, Astrinidis A*, Piekorz RP*, Pujana MA*. TACC3-TSC2 maintains nuclear envelope structure and controls cell division. Cell Cycle, 9, 1143-1155 (*korrespondierende Autoren).

Beer-Hammer S*, Zebedin E, von Holleben M, Alferink J, Reis B, Dresing P, Degrandi D, Scheu S, Hirsch E, Sexl V, Pfeffer K, Nürnberg B, Piekorz RP* (2010). Contribution of the catalytic PI3K isoforms p110g and p110g to B cell development and maintenance, transformation and proliferation. (*korrespondierende Autoren)., J. Leukoc. Biol., 87, 1083-1095.

Piekorz RP (2010). Dissecting the role of INCENP-Aurora B in chromosome alignment, spindle assembly, checkpoint activity, and cytokinesis. N&V. Cell Cycle, 9(9), 1-2.

Stan A, Pielarski KN, Brigadski T, Wittenmayer N, Fedorchenko O, Gohla A, Lessmann V, DresbaT, Gottmann  K.

Institute for Neuro- and Sensory Physiology, Biologisch-Medizinisches Forschungszentrum, Heinrich-Heine University Düsseldorf, 40225 Düsseldorf, Germany.

Frasa MA, Maximiano FC, Smolarczyk K, Francis RE, Betson ME, Lozano E, Goldenring J, Seabra MC, Rak A, Ahmadian MR, Braga VM. Armus is a Rac1 effector that inactivates Rab7 and regulates E-cadherin

degradation. Curr Biol. 2010 Feb 9;20(3):198-208.

Gazdag EM, Cirstea IC, Breitling R, Lukes J, Blankenfeldt W and Alexandrov K. Purification and crystallization of human Cu/Zn superoxide dismutase recombinantly produced in the protozoan Leishmania tarentolae. Acta Cryst. (August 2010). F66, 871–877.

Chen YX, Koch S, Uhlenbrock K, Weise K, Das D, Gremer L, Brunsveld L, Wittinghofer A, Winter R, Triola G,

Waldmann H. Synthesis of the Rheb and K-Ras4B GTPases. Angew Chem Int Ed Engl. 2010 Jul 22.

Rosnizeck IC, Graf T, Spoerner M, Tränkle J, Filchtinski D, Herrmann C, Gremer L, Vetter IR, Wittinghofer A, König B, Kalbitzer HR. Stabilizing a weak binding state for effectors in the human ras protein by cyclen complexes. Angew Chem Int Ed Engl. 2010 May 17;49(22):3830-3.

Schmidt S, Schneider L, Essmann F, Cirstea IC, Kuck F, Kletke A, Jänicke RU, Wiek C, Hanenberg H, Ahmadian MR, Schulze-Osthoff K, Nürnberg B, Piekorz RP (2010). The centrosomal protein TACC3 controls paclitaxel sensitivity by modulating a premature senescence program. Oncogene, in press.



2009

 

 

Kurig B, Shymanets A, Bohnacker T, Prajwal, Brock C, Ahmadian MR, Schaefer M, Gohla A, Harteneck C,

Wymann MP, Jeanclos E, Nürnberg B.

Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20312-7. Epub 2009 Nov 11.PMID: 19906996 [PubMed - in process] Related articles

Eberth, A. and Ahmadian, M.R. In vitro GEF and GAP assays. Curr. Protoc. Cell Biol., 2009 Jun;Chapter

14:Unit 14.9.

Shymanets, A., Ahmadian, M.R. and Nürnberg, B. (2009) G??-copurified lipid kinase impurity from Sf9 cells. Protein Pept Lett. 2009 Sep 10. [Epub ahead of print].

Eberth, A., Lundmark, R., Gremer, L., Dvorsky, R., Koessmeier, K.T., McMahon, H.T. and Ahmadian, M.R. (2009) A BAR domain-mediated autoinhibitory mechanism for RhoGAPs of the GRAF family. Biochem. J. 417, 371-377.

Albarrán-Juárez J*, Gilsbach R*, Piekorz RP, Pexa K, Beetz N, Schneider J, Nürnberg B, Birnbaumer L, Hein L (2008). Modulation of a2-adrenoceptor functions by heterotrimeric Gai isoforms. J. Pharmacol. Exp. Ther., 331, 35-44.

Abstract

 2008

 

 

Gremer, L., Gilsbach, B., Ahmadian, M.R. and Wittinghofer, A. (2008) Fluoride complexes of oncogenic Ras mutants to study the Ras-RasGAP-interaction. Biol. Chem. 389, 1163-1171.

Gasper, R., Thomas, C., Ahmadian, M.R. and Wittinghofer, A. (2008) The role of the conserved switch II glutamate in guanine nucleotide exchange factor-mediated nucleotide exchange of GTP-binding proteins. J. Mol. Biol. 379, 51-63.

Pena, V., Hothorn, M., Eberth, A., Kaschau, N., Parret, A., Gremer, L., Bonneau, F., Ahmadian, M.R. and Scheffzek, K. (2008) The C2 domain of synGAP is essential for stimulation of the Rap GTPase reaction. EMBO Rep., 9, 344–349.

Klionsky D., ..... Gohla A., ..... Nürnberg B., et al. (2008): Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy, volume 4 | issue 2 Pages: 151 - 175

Gasper R., Thomas C., Ahmadian MR., Wittinghofer A. (2008):The role of the conserved switch II glutamate in guanine nucleotide exchange factor-mediated nucleotide exchange of GTP-binding proteins.J Mol Biol, 379: 51-63.

Zebedin E, Simma O, Schuster C, Fajmann S, Eckelhart E, Warsch W, Putz, EM, Eckelhart E,

Stoiber D, Weisz E, Schmid JE, Pickl W, Valent P, Baumgartner C, Piekorz RP, Freissmuth M,

Sexl V (2008). Leukaemic challenge unmasks a requirement of PI3Kd in NK cell degranulation.

Blood, 112, 4655-4664.

Schneider L., Essmann F., Kletke A., Rio P., Hanenberg H., Schulze-Osthoff K., Nürnberg B., Piekorz.(2008): RPTACC3 depletion sensitizes to paclitaxel-induced cell death and overrides p21WAF-mediated cell cycle arrest. Oncogene, 27: 116-25.

Cortese MM., Suschek CV., Wetzel W., Kröncke KD., Kolb-Bachofen V. (2008): Zinc protects endothelial cells from hydrogen peroxide via Nrf2-dependent stimulation of glutathione biosynthesis. Free Radic Biol Med, 44: 2002-2012.

Abstract

 

 

2007

 

van der Burgt, I., Kupsky, W., Stassou, S., Nadroo, A., Barroso, C., Diem, A., Kratz, C., Dvorsky, R., Ahmadian, M.R. and Zenker, M. Myopathy caused by HRAS germline mutations - implications on disturbed myogenic differentiation in the presence of constitutive H-Ras activation. J.Med.Genet., 44, 459-462.

Olsen, H., Herbrand, U., ter Veld, F., Ahmadian, M.R. and Wehner, F. (2007) Differential regulation of cell volume and shape in confluent rat hepatocytes under hypertonic stress. Cell. Physiol. Biochem. 19, 259-268.

Roeglin, L., Hemsath, L., Ahmadian, M.R. and Seitz, O. (2007) DNA-triggered reversible switching of peptide conformation and bioactivity. Angew. Chem. Int. Ed. Engl. 46, 2704-2707.

Gotthardt, K. and Ahmadian, M.R. (2007) Asef is a Cdc42-specific guanine nucleotide exchange factor. Biol. Chem., 388, 67-71.

Schneider L., Essmann F., Kletke A., Rio P., Hanenberg H., Schulze-Osthoff  K., Nürnberg B., Piekorz RP (2007): TACC3 depletion sensitizes to paclitaxel-induced cell death and overrides p21(WAF)-mediated cecycle arrest. Oncogene, in press, June 25.

Gohla A., Klement K., Nürnberg B. (2007): The heterotrimeric G protein G(i3) regulates hepatic autophagy downstream of the insulin receptor.  Autophagy, 3: 393-395

 Gohla A., Klement K., Piekorz R.P., Pexa  K., Vom Dahl S., Spicher K., Dreval V., Haussinger D., Birnbaumer L. and Nurnberg B. (2007): An obligatory requirement for the heterotrimeric G protein Gi3 in the antiautophagic action of  insulin in the liver. Proc. Natl. Acad. Sci. U S A, 104: 3003-3008

 Pero RS., Borchers MT., Spicher K., Ochkur SI, Sikora L., Rao SP., Abdala-Valencia H., O'neill KR., Shen H., McGarry MP., Lee NA., Cook-Mills JM., Sriramarao P., Simon MI., Birnbaumer L. and Lee JJ. (2007): G?i2-mediated signaling events in the endothelium are involved in controlling leukocyte extravasation. Proc. Natl. Acad. Sci. U S A, 104: 4371-4376

Abstract

 

 

2006

 

 

Kolb-Bachofen V., Kuhn A. and Suschek C.V. (2006): The role of nitric oxide. Rheumatology (Oxford), 45: iii17-iii19

 Wethkamp N., Ramp U., Geddert H., Schulz W.A., Florl A.R., Suschek C.V., Hassan M., Gabbert H.E. and Mahotka C. (2006): Expression of death-associated protein kinase during tumour progression of human renal cell carcinomas: hypermethylation-independent mechanisms of inactivation. Eur J Cancer, 42:264-74

Fan H., Williams D.L., Zingarelli B., Breuel K.F., Teti G., Tempel G.E., Spicher K., Boulay G., Birnbaumer L., Halushka P.V. and Cook J.A. (2006): Differential regulation of lipopolysaccharide and Gram-positive bacteria induced cytokine and chemokine production in splenocytes by Galphai proteins. Biochim Biophys Acta, 1763: 1051-1058
Abstract


Gatzka M., Piekorz R., Moriggl R., Rawlings J. and Ihle J.N. (2006): A role for STAT5A/B in protection of peripheral T-lymphocytes from postactivation apoptosis: insights from gene expression profiling. Cytokine, 34: 143-154
Abstract

Ehrhardt C., Marjuki H., Wolff T., Nürnberg B., Planz O., Pleschka S. and Ludwig S. (2006): Bivalent role of the phosphatidylinositol-3-kinase (PI3K) during influenza virus infection and host cell defence. Cell. Microbiol, 8: 1336-1348
Abstract

Cronauer M.V., InceY., Engers R., Rinnab L., Weidemann W., Suschek C.V., Burchardt M., Kleinert H., Wiedenmann J., Sies H., Ackermann R. and Kroncke K.D. (2006): Nitric oxide-mediated inhibition of androgen receptor activity: possible implications for prostate cancer progression.Oncogene,18: [Epub ahead of print]

Suschek C.V., Schewe T., Sies H. and Kroncke K.D. (2006): Nitrite, a naturally occurring precursor of nitric oxide that acts like a 'prodrug'. Biol. Chem, 387:, 499-506
Abstract

 

 

2005

 

Skokowa J., Ali S.R., Felda O., Kumar V., Konrad S., Shushakova N., Schmidt R.E., Piekorz R.P., Nürnberg B., Spicher K., Birnbaumer L., Zwirner J., Claassens J.W.C., Verbeek J.S., van Rooijen N., Köhl J., Gessner J.E. (2005): Macrophages induce the inflammatory response in the pulmonary Arthus reaction through G?i2 activation that controls C5aR and Fc receptor cooperation. Journal of Immunology, 174: 3041-3050

Piekorz R.P., Gingras S., Hoffmeyer A., Ihle JN., Weinstein Y. (2005): Regulation of progesterone levels during pregnancy and parturition by Stat5 and 20?-hydroxysteroid dehydrogenase - hydroxysteroid dehydrogenase. Molecular Endocrinology, 19: 431-440
Abstract


Voigt P., Brock C., Nürnberg B., Schaefer M. (2005): Assigning functional domains within the p101 regulatory subunit of phosphoinositide 3-kinase ?. Journal of Biological Chemistry, 280: 5121-5127
Abstract


Reppel M., Sasse P., Piekorz RP., Tang M., Roell W., Duan Y., Kletke A., Hescheler J., Nürnberg B., Fleischmann BK. (2005): S100A1 enhances the L-type Ca2+ current in embryonic mouse and neonatal rat ventricular cardiomyocytes. Journal of Biological Chemistry, doi:10.1074/jbc.M504750200.


Bo Wei., Peter Velazquez., Olga Turovskaya., Karsten Spricher., Richard Aranda., Mitchell Kronenberg., Lutz Birnbaumer and Jonathan Braun (2005): Mesenteri B cells centrally inhibit CD4+ T cell colitis through interaction with regulatory T cell subsets. Proc. Natl. Acad. Sci. U S A,  102:2010-2015  
Abstract

Cully MJ., Shiu J., Piekorz RP., Muller WJ., Done SJ., Mak TW (2005). TACC1 promotes transformation and mammary tumorigenesis. Cancer Research, 65:10363-10370

Abstract

 

 

2004

 

Kreuzer J., Nürnberg B., Krieger-Brauer H.I. (2004): Ligand-dependent autophosphorylation of the insulin receptor is positively regulated by Gi-proteins. Biochemical Journal, 380: 831-836
Abstract

Viard P., Butcher A.J., Halet G., Davies A., Nürnberg B., Heblich F., Dolphin A.C. (2004): PI3K promotes voltage-dependent calcium channel trafficking to the plasma membrane. Nature Neuroscience, 7: 93-946
Abstract

Leemhuis J., Boutillier S., Barth H., Feuerstein T., Brock C., Nürnberg B., Aktories K., Meyer D.K. (2004): Rho GTPases and phosphoinositide 3-kinase organize formation of branched dendrites. Journal of BiologicalChemistry, 279: 585-596
Abstract

Schündeln M., Piekorz R.P, Wichmann C., Lee Y., Takahashi Y., McKinnon P., Ihle J.N. (2004): The centrosomal, putative tumor suppressor TACC2 is dispensable for normal development, and deficiency does not lead to cancer. Molecular and Cellular Biology, 24: 6403-6409
Abstract

 

 

2003

 

Brock C., Schaefer M., Reusch HP., Czupalla C., Michalke M., Spicher K., Schultz G., Nürnberg B. (2003): Roles of G?? in membrane recruitment and activation of p110? /p101 phosphoinositide 3-kinase ?.

Journal of Cell Biology, 160: 89-99
Abstract

Czupalla C., Culo M., Müller E.C., Brock C., Reusch H.P., Spicher K., Krause E., Nürnberg B. (2003): Identification and characterization of the autophosphorylation sites of phosphoinositide 3-kinase isoforms ? and ?. Journal of Biological Chemistry, 278: 11536-545
Abstract

Czupalla C., Nürnberg B., Krause E. (2003): Analysis of class I phosphoinsotide 3-kinase autophosphorylation sites by mass spectrometry. Rapid Communications in Mass Spectrometry, 17: 690-696
Abstract

Pahner I., Höltje M., Winter S., Takamori S., Bellocchio E.E., Spicher K., Laake P., Nürnberg B., Ottersen O.P., Ahnert-Hilger G. (2003): Functional G-protein heterotrimers are associated with vesicles of putative glutamatergic terminals: implications for regulation of transmitter uptake. Molecular Cell Neuroscience, 23: 398-413 Corrigendum 24: 850
Abstract

Mittmann C., Pinkepank G., Stamatelopoulou S., Wieland T., Nürnberg B., Hirt S., Eschenhagen T. (2003): Differential coupling of m-cholinoceptors to Gi/Go proteins in human myocardium. Journal of Molecular and Cellular Cardiology, 35: 1241-1249
Abstract

Shelburne C.P., McCoy M.E., Piekorz R.P., Sexl V., Roh K.H., Jacobs-Helber S.M., Gillespie S.R., Bailey D.P., Gharse A., Mirmonsef P., Mann M.N., Kashyap M., Wright H.V., Chong H.J., Bouton L.A., Barnstein B., Ramirez C.D., Lantz C.S., Ryan J.J. (2003): STAT5 expression is critical for mast cell development and survival. Blood, 102: 1290-1297
Abstract

Sexl V., Kovacic B., Piekorz R.P., Moriggl R., Stoiber D., Hoffmeyer A., Weisz E., Liebminger R., Rothammer K., Ihle J.N. (2003): Jak1 deficiency leads to enhanced Abelson-induced B cell tumor formation. Blood, 101: 4937-4943
Abstract

 

 

2002

 

Breitweg-Lehmann E., Czupalla C., Storm R., Kudlacek O., Schunack W., Freissmuth M., Nürnberg B. (2002): Activation and inhibition of G proteins by lipoamines. Molecular Pharmacology, 61: 628-636

Garnham B.M., Fitzpatrick-Wong S., Schunack W., Nürnberg B., Sorrentino G., Parkinson F.E., Kanfer J.N., Sitar D.S. (2002): Activation of phospholipases A2 and D of a human neuroblastoma cell line (LA-N-2) by N-dodecyl-L-lysine amide (compound 24), a putative G protein activator: Characteristics of inhibition by (-)-nicotine. Neurochemical Research, 27 (12): 1613-618
Abstract

Pahner I., Höltje M., Winter S., Nürnberg B., Ottersen O.-P., Ahnert-Hilger G. (2002): Subunit composition and functional properties of G-protein heterotrimers on rat chromaffin granules. European Journal of Cell Biology, 81: 449-456
Abstract

Jou S.T., Carpino N., Takahashi Y., Piekorz R.P., Chao J.R., Carpino N., Wang D., Ihle J.N. (2002): An essential, non-redundant role for the phosphoinositide 3-kinase p110? in signaling by the B cell receptor complex. Molecular and Cellular Biology, 22: 8580-8591
Abstract

Shelburne C.P., Piekorz R.P., Bouton L.A., Chong H.J., Ryan J.J. (2002): Mast cells do not express a novel isoform of Stat6. Cytokine, 19: 218-227
Abstract

Piekorz R.P., Hoffmeyer A., Duntsch C.D., McKay C., Nakajima H., Sexl V., Snyder L., Rehg J., Ihle J.N. (2002): The centrosomal protein TACC3 is essential for hematopoietic stem cell function and genetically interfaces with p53 regulated apoptosis. EMBO Journal, 21: 653-664
Abstract

 

 

Fusion Protein Technologies for Biopharmaceuticals: Applications and Challenges 

 

 

Doreen M. Floss, Udo Conrad, Stefan Rose-John, and Jürgen Scheller 

ISBN-10: 0470646276

ISBN-13: 978-0470646274

Just H., Stefan E., Czupalla C., Nürnberg B., Nanoff C., Freissmuth M. (2001): Beyond G proteins: the role of accessory proteins in G protein-coupled receptor signaling. van der Goot H. (Hrsg.): Trends in Drug Research III. Elsevier Science B.V., Amsterdam, NL, S. 161-173

Nürnberg B. Monographien. Blasche W., Ebel S., Hackethal E., Holzgrabe U., Keller K., Reichling J. (Hrsg.): HagerROM 2002. Hagers Handbuch der Drogen und Arzneistoffe, update. Springer Verlag, Berlin. Heidelberg, ISBN 3-540-14908-2.

Nürnberg B., Kleuser B. Monographien. Blasche W., Ebel S., Hackethal E., Holzgrabe U., Keller K., Reichling J. (Hrsg.): HagerROM 2003. Hagers Handbuch der Drogen und Arzneistoffe, update. Springer Verlag, Berlin. Heidelberg, ISBN 3-540-14952-X

Nürnberg B. Phospholipid kinases. Offermanns S., Rosenthal W. (Hrsg.), Molecular Pharmacology, an Encyclopedic Reference. Springer Verlag, Berlin, Heidelberg, S. 739-743

Nürnberg B. Classification and functional properties of G proteins. The Nature Reviews Drug Discovery GPCR Questionnaire Participants. The Stat of GPCR Research in 2004. Nature Reviews in Drug Discovery,2004, 3:575-626

Piekorz R.P., Nürnberg B. Phospholipid kinases. Enna S.J., Bylund (Hrsg.), X-Pharm. Elsevier Inc., New York
Abstract

Nürnberg B., Piekorz R.P. Monographien. Blasche W., Ebel S., Hackethal E., Holzgrabe U., Keller K., Reichling J. (Hrsg.): HagerROM 2004. Hagers Handbuch der Drogen und Arzneistoffe, update. Springer Verlag, Berlin. Heidelberg, im Druck

Nürnberg B. Phosphoinositide 3-kinase p110 ?, class Ib catalytic subunit. Alliance for Celular Signaling (AfCS), kostenlose Registrierung erforderlich.
Abstract

Nürnberg B. Phosphoinositide 3-kinase p110?, class Ib catalytic subunit. Alliance for Celular Signaling (AfCS),kostenlose Registrierung erforderlich.
Abstract

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