Interview of International Innovation with Carsten Korth from July 2012 on Mental illness Research. download 2012_interview_CK

See here a video on our research strategy in schizophrenia research: https://vimeo.com/133542777

A complete list can be retrieved from PubMed by clicking on this link
Access to most full-length papers can be obtained using this link

2022

Seidisarouei M, Schäble S, van Wingerden M, Trossbach SV, Korth C, Kalenscher T  (2022) Social anhedonia as a Disrupted-in-Schizophrenia 1-dependent phenotype. Sci Rep. 2022 Jun 17;12(1):10182. doi: 10.1038/s41598-022-14102-3.

Wang AL, Chao OY, Nikolaus S, Lamounier-Zepter V, Hollenberg CP, Lubec G, Trossbach SV, Korth C, Huston JP.(2022) Disrupted-in-schizophrenia 1 Protein Misassembly Impairs Cognitive Flexibility and Social Behaviors in a Transgenic Rat Model. Neuroscience. 2022 Apr 21;493:41-51. doi: 10.1016/j.neuroscience.2022.04.013. Online ahead of print.

Selvarajah S, Lingappa AF, Michon M, Du L, Deiter F, Yu SF, Macieik A, Mallesh S, Appaiah U, Crabtree J, Copeland K, Müller-Schiffmann A, Müller L, Ostermann PN, Andrée M, Adams O, Schaal H, Hogan RJ, Tripp RA, Anand SK, Campi TW, Ford MJ, Reed JC, Lin J, Akintunde O, Nichols C, Petrouski E, Moreira AR, Jiang IT, DeYarman N, Broce S, Brown I, Lau S, Segal I, Goldsmith D, Hong S, Asundi V, Briggs EM, Phyo NS, Froehlich M, Onisko B, Matlack K, Dey D, Lingappa JR, Prasad MD, Korth C, Kitaygorodskyy A, Solas D, Boushey H, Greenland J, Pillai S, Paulvannan K, Lingappa VR (2022) From COVID-19 to the Common Cold: Novel Host-Targeted, Pan-Respiratory Antiviral Small Molecule Therapeutics. bioRxiv. 2021 Dec 13:2021.01.17.426875. doi: 10.1101/2021.01.17.426875. Preprint.

2021

van Gerresheim EF, Herring A, Gremer L, Müller-Schiffmann A, Keyvani K, Korth C. (2021) The interaction of insoluble Amyloid-β with soluble Amyloid-β dimers decreases Amyloid-β plaque numbers. Neuropathology and Applied Neurobiology. 47(5):603-610.

Müller-Schiffmann A, Trossbach SV, Lingappa VR, Korth C (2021) Viruses as truffle hounds for the discovery of brain cellular pathology. Trends in Neurosciences 11:S0166-2236(20)30267-8. doi: 10.1016/j.tins.2020.11.004.

Müller-Schiffmann A,  Torres T, Kitaygorodskyy A, Ramani A, Alatza A , Sarah Tschirner S , Ingrid Prikulis I , Shaofeng Y , Debendranath Dey D, Bader V, Rozemuller A, Wray S, Gopalakrishnan J,  Riek R, Lingappa VR, Korth C (2021) Macrophage migration inhibitory factor is a valid drug target at the intersection of herpes simplex virus 1 replication and Alzheimer´s disease-relevant cellular pathology. www.biorxiv.org/content/10.1101/2021.09.11.459903v1 (Preprint)

Verberk IMW, Koel-Simmelink M, Twaalfhoven H, Vrenken H, Korth C, Killestein J, Teunissen CE, Bridel C (2021) Ultrasensitive immunoassay allows robust measurement of serum neurofilament heavy in Multiple Sclerosis. Multiple Sclerosis and Related Disorders 2021 Feb 10;50:102840. doi: 10.1016/j.msard.2021.102840

2020

Marreiros R, Müller-Schiffmann A, Trossbach SV, Prikulis I, Hänsch S, Weidkamp-Peters S, Moreira AR, Sahu S, Soloviev I, Selvarajah S, Lingappa VR, Korth C (2020) Disruption of cellular proteostasis by H1N1 influenza A virus causes -synuclein aggregation. Proceedings of the National Academy of Sciences USA, 117(12):6741-6751.

Korth C & Fangerau H (2020) Blood tests for diagnosing schizophrenia: self-inflicted limits in psychiatry. The Lancet Psychiatry 7(10):911-914.

Ramani A, Müller L, Osterman PN, Gabriel E, Abida-Islam P, Müller-Schiffmann A, Mariappan A, Goureau O, Gruell H, Walker A, Andrée M, Hauka S, Houwaart T, Dilthey A, Wohlgemuth K, Omran H, Klein F, Wieczorek D, Adams O, Timm J, Korth C, Schaal H, Gopalakrishnan J (2020) SARS-CoV-2 targets neurons of 3D human brain organoids. EMBO Journal, e2020106230. doi: 10.15252/embj.2020106230

Nani JV, Fonseca MC, Engi SA, Perillo MG, Dias CSB, Gazarini ML, Korth C, Cruz F, Hayashi MAF (2020) Decreased Ndel1 enzyme activity in an animal model with dysfunctional DISC1 signaling featuring aberrant neurodevelopment and amphetamine-supersensitivity. Journal of Psychopharmacology 34:467-477.

Martins S, Müller-Schiffmann A, Erichsen L, Bohndorf M, Wruck W, Sleegers K, Van Broeckhoven C, Korth C, Adjaye J (2020) IPSC-derived neurional cultures carrying the Alzheimer’s disease associated TREM R47H variant enables the construction of an Abeta-induced regulatory network.  International Journal of Molecular Sciences 2020 Jun 25;21(12):4516.

Korth C (2020) Tools as „petrified memes“: a duality. Brain and Behavioral Sciences 10;43:e169.

2019

Trossbach SV, Hecher L, Schafflick D, Lautwein T, Tschirner S Deenen R, Köhrer K, Fehsel K, Papazova I, Malchow B, Hasan A, Winterer G, Schmitt A, Hörste G, Falkai P, Korth C (2019) Dysregulation of a specific immune-related network of genes biologically defines a subset of schizophrenia. Translational Psychiatry 9(1):156.

Bradshaw NJ & Korth C (2019) Protein misassembly and aggregation as potential convergence points for non-genetic causes of chronic mental illness. Molecular Psychiatry, 24(7):936-951.

Uzuneser T, Speidel J, Kogias G, Wang AL, e Souza Silva MA, Huston JP, Zoicas I, von Horsten S, Kornhuber J, Korth C, Müller CP (2019). Disrupted-in-schizophrenia 1 (DISC1) mutation and juvenile immune activation cause sex specific schizophrenia-related psychopathology in rats. Frontiers in Psychiatry, 10:222

Käfer K, Malagon-Vina H, Dickerson DD, O’Neill J, Trossbach SV, Korth C, Csicsvari J. DISC1 overexpression disrupts hippocampal coding and oscillatory synchronization. (2019). Disrupted-in-schizophrenia 1 overexpression disrupts hippocampal coding and oscillatory synchronization. Hippocampus 29(9):802-816.

Wang AL, Chao OY, Yang YM, Trossbach SV, Müller CP, Korth C, Huston JP, de Souza Silva MA (2019). Anxiogenic-like behavior and deficient attention/working memory in rats expressing the human DISC1 gene. Pharmacology and Biochemistry of Behavior 179:73-79.

Dahoun T, Nour MM, Adams RA, Trossbach S, Lee SH, Patel H, Curtis C, Korth C, Howes OD. (2019) Disrupted-in-schizophrenia 1 functional polymorphisms and D2 /D3 receptor availability: A [11 C]-(+)-PHNO imaging study. Genes Brain Behav. e12596.

2018

Ramos A, Rodríguez-Seoane C, Rosa I, Gorroño-Etxebarria I, Alonso J, Veiga S, Korth C, Kypta RM, García Á, Requena JR. (2018) Proteomic Studies Reveal Disrupted in Schizophrenia 1 as a Player in Both Neurodevelopment and Synaptic Function. International Journal of Molecular Sciences 20(1). pii: E119. doi: 10.3390/ijms20010119.

Dahoun T, Pardiñas AF, Veronese M, Bloomfield MAP, Jauhar S, Bonoldi I, Froudist-Walsh S, Nosarti C, Korth C, Hennah W, Walters J, Prata D, Howes OD (2018) The effect of the DISC1 Ser704Cys polymorphism on striatal dopamine synthesis capacity: an [18F]-DOPA PET study. Human Molecular Genetics doi: 10.1093/hmg/ddy242.

Abdel-Hafiz L, Müller-Schiffmann A, Korth C, Fazari B, Nikolaus S, Schäble S, Herring A, Keyvani K, Lamounier-Zepter V, Huston JP, de Souza Silva MA. (2018) Aβ dimers induce behavioral and neurochemical deficits of relevance to early Alzheimer’s disease. Neurobiology of Aging 69:1-9.

Wang AL, Fazari B, Chao OY, Nikolaus S, Trossbach SV, Korth C, Sialana FJ, Lubec G, Huston JP, Mattern C, de Souza Silva MA (2017) Intra-nasal dopamine alleviates cognitive deficits in tgDISC1 rats which overexpress the human DISC1 gene. Neurobiology of Learning and Memory pii: S1074-7427(17)30166-1. doi: 10.1016/j.nlm.2017.10.015.

Sialana FJ, Wang AL, Fazari B, Kristofova M, Smidak R, Trossbach SV, Korth C, Huston JP, de Souza Silva MA, Lubec G. (2018) Quantitative Proteomics of Synaptosomal Fractions in a Rat Overexpressing Human DISC1 Gene Indicates Profound Synaptic Dysregulation in the Dorsal Striatum. Frontiers in Molecular Neuroscience;11:26. doi: 10.3389/fnmol.2018.00026.

Yerabham ASK, Müller-Schiffmann A, Ziehm T, Stadler A, Köber S, Indurkhya X, Marreiros R, Trossbach SV, Bradshaw NJ, Prikulis I, Willbold D, Weiergräber OH, Korth C. (2018) Biophysical insights from a single chain camelid antibody directed against the Disrupted-in-Schizophrenia 1 protein. PLoS One 13(1):e0191162.

2017

Gowert NS, Krüger I, Klier M, Donner L, Kipkeew F, Gliem M, Bradshaw NJ, Lutz D, Köber S, Langer H, Jander S, Jurk K, Frotscher M, Korth C, Bock HH, Elvers M (2017) Loss of Reelin protects mice against arterial thrombosis by impairing integrin activation and thrombus formation under high shear conditions. Cell Signaling 210-221. doi: 10.1016/j.cellsig.2017.09.016

Bradshaw NJ, Yerabham ASK, Marreiros R, Zhang T, Nagel-Steger L, Korth C (2017) An unpredicted aggregation-critical region of the actin-polymerizing protein TRIOBP-1/Tara, determined by elucidation of its domain structure. Journal of Biological Chemistry 292(23):9583-9598.

Bradshaw NJ, Trossbach SV, Köber S, Walter S, Prikulis I, Weggen S, Korth C Disrupted in Schizophrenia 1 regulates the processing of reelin in the perinatal cortex. (2017) Schizophrenia Research doi: 10.1016/j.schres.2017.04.012.

Yerabham AS, Mas PJ, Decker C, Soares DC, Weiergräber OH, Nagel-Steger L, Willbold D, Hart DJ, Bradshaw NJ, Korth C. (2017) A Structural Organization for Disrupted in Schizophrenia 1, Identified by High-Throughput Screening, Reveals Distinctly Folded Regions Which Are Bisected by Mental Illness-Related Mutations. Journal of Biological Chemistry 292(16):6468-6477.

Zhu S, Abounit S, Korth C, Zurzolo C (2017) Transfer of Disrupted-in-Schizophrenia 1 (DISC1) aggregates between neuronal cells occurs in tunneling nanotubes and is promoted by dopamine Open Biology 7(3). pii: 160328.

Dahoun T, Trossbach SV, Brandon NJ, Korth C, Howes O (2017) The impact of Disrupted-in-Schizophrenia 1 on the dopaminergic system: a systematic review Translational Psychiatry 7(1):e1015.

2016

Müller-Schiffmann A, Herring A, Abdel-Hafiz L, Schäble S, Wedel D, Tchepkova AN, Horn AHC, Sticht H, de Souza Silva MA, Sergeeva O, Gottmann K, Huston JP, Keyvani K, Korth C. (2016) Aβ dimers in the absence of plaque pathology are sufficient to impair learning and synaptic plasticity. Brain, 139:509-25.

Trossbach SV, Bader V, Hecher L, Pum ME,  Prikulis I, Schäble S, de Souza Silva MA, Su P, Boulat B, Chwiesko C, Lohr KM, Stout KA, Weisshaupt, Masoud S, Godsave SF, Bilzer T, Steiner H, Peters PJ, Bauer A, Sauvage M, Ramsey AJ, Miller GW, Liu F, Seeman P, Brandon NJ, Huston JP, Korth C. (2016) Misassembly of non-mutant Disrupted-in-schizophrenia 1 (DISC1) protein is linked to altered dopamine homeostasis and behavioral deficits. Molecular Psychiatry 21:1561-1572.

Bader V, Trossbach SV, Prikulis I, Godsave SF, Peters PJ, Korth C. (2017) Misassembly of non-mutant full-length Disrupted-in-Schizophrenia 1 protein is induced by dopamine in vitro and in vivo. Molecular Psychiatry 21(11):1487. doi: 10.1038/mp.2016.190.

Hamburg H, Trossbach SV, Bader V, Chwiesko C, Kipar A, Sauvage M, Crum WR, Vernon AC, Bidmon HJ, Korth C (2016) Simultaneous effects on parvalbumin- interneuron and dopaminergic system development in a transgenic rat model for sporadic schizophrenia. Scientific Reports 6:  34946.

Vomund S, de Souza Silva MA, Huston JP, Korth C. Behavioral Resilience and Sensitivity to Locally Restricted Cortical Migration Deficits Induced by In Utero Knockdown of Disabled-1 in the Adult Rat. (2016) Cerebral Cortex 27(3):2052-2063.

Streich C, Akkari L, Decker C, Bormann J, Rehbock C, Müller-Schiffmann A, Niemeyer FC, Nagel-Steger L, Willbold D, Sacca B, Korth C, Schrader T, Barcikowski S. (2016) Characterizing the Effect of Multivalent Conjugates Composed of Aβ-Specific Ligands and Metal Nanoparticles on Neurotoxic Fibrillar Aggregation. ACS Nano. 2016 Aug 23;10(8):7582-97.

Storck SE, Meister S, Nahrath J, Meißner JN, Schubert N, Di Spiezio A, Yvonne Bouter Y, Baches S, Prikulis I, Korth C, Weggen S, Heimann A, Schwaninger M, Bayer  TA, Pietrzik CU.(2016) Brain endothelial-specific deletion of Lrp1 demonstrates that blood-brain barrier is a central pathway for Aβ clearance. Journal of Clinical Investigation, 126(1):123-36.

Steffen J, Krohn M, Paarmann K, Schwitlick C, Brüning T, Marreiros R, Müller-Schiffmann A, Korth C, Braun K, Pahnke J (2016) Revisiting rodent models: octodon degus as Alzheimer’s disease model? Acta Neuropathologica Communications 4(1):91.

Requena JR, Kristensson K, Korth C, Zurzolo C, Simmons M, Aguilar-Calvo P, Aguzzi A, Andreoletti O, Benestad SL, Böhm R, Brown K, Calgua B, Del Río JA, Espinosa JC, Girones R, Godsave S, Hoelzle LE, Knittler MR, Kuhn F, Legname G, Laeven P, Mabbott N, Mitrova E, Müller-Schiffmann A, Nuvolone M, Peters PJ, Raeber A, Roth K, Schmitz M, Schroeder B, Sonati T, Stitz L, Taraboulos A, Torres JM, Yan ZX, Zerr I (2016) The Priority position paper: Protecting Europe's food chain from prions. Prion. 2016 May 3;10(3):165-81.