Interview of International Innovation with Carsten Korth from July 2012 on Mental illness Research. download 2012_interview_CK

See here a video on our research strategy in schizophrenia research:

Retrieve an updated list of publications from PubMed by clicking on this link



Dahoun T, Nour MM, Adams RA, Trossbach S, Lee SH, Patel H, Curtis C, Korth C, Howes OD. Disrupted-in-Schizophrenia 1 (DISC1) functional polymorphisms and D2 /D3 receptor availability: a [11 C]-(+)-PHNO imaging study. Genes Brain Behav. 2019 Jul 2:e12596. doi: 10.1111/gbb.12596. [Epub ahead of print] PubMed

Kaefer K, Malagon-Vina H, Dickerson DD, O'Neill J, Trossbach SV, Korth C, Csicsvari J. Disrupted-in-schizophrenia 1 overexpression disrupts hippocampal coding and oscillatory synchronization. Hippocampus. 2019 Feb 5. doi: 10.1002/hipo.23076. [Epub ahead of print] PubMed

Bradshaw NJ, Trossbach SV, Köber S, Walter S, Prikulis I, Weggen S, Korth C. Disrupted in Schizophrenia 1 regulates the processing of reelin in the perinatal cortex. Schizophr Res. 2017 Apr 19. pii: S0920-9964(17)30200-1. doi: 10.1016/j.schres.2017.04.012. [Epub ahead of print] PubMed

Bradshaw NJ, Korth C. Protein misassembly and aggregation as potential convergence points for non-genetic causes of chronic mental illness. Mol Psychiatry. 2019 Jul;24(7):936-951. doi: 10.1038/s41380-018-0133-2. Epub 2018 Aug 8. PubMed

Trossbach SV, Hecher L, Schafflick D, Deenen R, Popa O, Lautwein T, Tschirner S, Köhrer K, Fehsel K, Papazova I, Malchow B, Hasan A, Winterer G, Schmitt A, Meyer Zu Hörste G, Falkai P, Korth C. Dysregulation of a specific immune-related network of genes biologically defines a subset of schizophrenia. Transl Psychiatry. 2019 May 31;9(1):156. doi: 10.1038/s41398-019-0486-6. PubMed

Uzuneser TC, Speidel J, Kogias G, Wang AL, de Souza Silva MA, Huston JP, Zoicas I, von Hörsten S, Kornhuber J, Korth C, Müller CP. Disrupted-in-Schizophrenia 1 (DISC1) Overexpression and Juvenile Immune Activation Cause Sex-Specific Schizophrenia-Related Psychopathology in Rats. Front Psychiatry. 2019 Apr 9;10:222. doi: 10.3389/fpsyt.2019.00222. eCollection 2019. PubMed

Wang AL, Chao OY, Yang YM, Trossbach SV, Müller CP, Korth C, Huston JP, de Souza Silva MA. Anxiogenic-like behavior and deficient attention/working memory in rats expressing the human DISC1 gene. Pharmacol Biochem Behav. 2019 Apr;179:73-79. doi: 10.1016/j.pbb.2019.02.005. Epub 2019 Feb 16. PubMed


Ramos A, Rodríguez-Seoane C, Rosa I, Gorroño-Etxebarria I, Alonso J, Veiga S, Korth C, Kypta RM, García Á, Requena JR. Proteomic Studies Reveal Disrupted in Schizophrenia 1 as a Player in Both Neurodevelopment and Synaptic Function. Int J Mol Sci. 2018 Dec 29;20(1). pii: E119. doi: 10.3390/ijms20010119. PubMed

Dahoun T, Pardiñas AF, Veronese M, Bloomfield MAP, Jauhar S, Bonoldi I, Froudist-Walsh S, Nosarti C, Korth C, Hennah W, Walters J, Prata D, Howes OD. The effect of the DISC1 Ser704Cys polymorphism on striatal dopamine synthesis capacity: an [18F]-DOPA PET study. Hum Mol Genet. 2018 Oct 15;27(20):3498-3506. doi: 10.1093/hmg/ddy242. PubMed

Abdel-Hafiz L, Müller-Schiffmann A, Korth C, Fazari B, Chao OY, Nikolaus S, Schäble S, Herring A, Keyvani K, Lamounier-Zepter V, Huston JP, de Souza Silva MA. Aβ dimers induce behavioral and neurochemical deficits of relevance to early Alzheimer's disease. Neurobiol Aging. 2018 Sep;69:1-9. doi: 10.1016/j.neurobiolaging.2018.04.005. Epub 2018 Apr 17. PubMed

Sialana FJ, Wang AL, Fazari B, Kristofova M, Smidak R, Trossbach SV, Korth C, Huston JP, de Souza Silva MA, Lubec G. Quantitative Proteomics of Synaptosomal Fractions in a Rat Overexpressing Human DISC1 Gene Indicates Profound Synaptic Dysregulation in the Dorsal Striatum. Front Mol Neurosci. 2018 Feb 6;11:26. doi: 10.3389/fnmol.2018.00026. eCollection 2018. PubMed

Yerabham ASK, Müller-Schiffmann A, Ziehm T, Stadler A, Köber S, Indurkhya X, Marreiros R, Trossbach SV, Bradshaw NJ, Prikulis I, Willbold D, Weiergräber OH, Korth C. Biophysical insights from a single chain camelid antibody directed against the Disrupted-in-Schizophrenia 1 protein. PLoS One. 2018 Jan 11;13(1):e0191162. doi: 10.1371/journal.pone.0191162. eCollection 2018. PubMed


Gowert NS, Krüger I, Klier M, Donner L, Kipkeew F, Gliem M, Bradshaw NJ, Lutz D, Köber S, Langer H, Jander S, Jurk K, Frotscher M, Korth C, Bock HH, Elvers M. Loss of Reelin protects mice against arterial thrombosis by impairing integrin activation and thrombus formation under high shear conditions. Cell Signal. 2017 Dec;40:210-221. doi: 10.1016/j.cellsig.2017.09.016. Epub 2017 Sep 21. PubMed

Wang AL, Fazari B, Chao OY3 Nikolaus S, Trossbach SV, Korth C, Sialana FJ, Lubec G, Huston JP, Mattern C, de Souza Silva MA. Intra-nasal dopamine alleviates cognitive deficits in tgDISC1 rats which overexpress the human DISC1 gene. Neurobiol Learn Mem. 2017 Dec;146:12-20. doi: 10.1016/j.nlm.2017.10.015. Epub 2017 Oct 28. PubMed

Bradshaw NJ, Yerabham ASK, Marreiros R, Zhang T, Nagel-Steger L, Korth C. An unpredicted aggregation-critical region of the actin-polymerizing protein TRIOBP-1/Tara, determined by elucidation of its domain structure. J Biol Chem. 2017 Jun 9;292(23):9583-9598. doi: 10.1074/jbc.M116.767939. Epub 2017 Apr 24. PubMed 

Yerabham AS, Mas PJ, Decker C, Soares DC, Weiergräber OH, Nagel-Steger L, Willbold D, Hart DJ, Bradshaw NJ, Korth C. A Structural Organization for Disrupted in Schizophrenia 1, Identified by High-Throughput Screening, Reveals Distinctly Folded Regions Which Are Bisected by Mental Illness-Related Mutations. J Biol Chem. 2017 Apr 21;292(16):6468-6477. doi: 10.1074/jbc.M116.773903. Epub 2017 Mar 1. PubMed

Zhu S, Abounit S, Korth C, Zurzolo C. Transfer of disrupted-in-schizophrenia 1 aggregates between neuronal-like cells occurs in tunnelling nanotubes and is promoted by dopamine. Open Biol. 2017 Mar;7(3). pii: 160328. doi: 10.1098/rsob.160328. PubMed

Vomund S, de Souza Silva MA, Huston JP, Korth C. Behavioral Resilience and Sensitivity to Locally Restricted Cortical Migration Deficits Induced by In Utero Knockdown of Disabled-1 in the Adult Rat. 2017 Mar 1;27(3):2052-2063. doi: 10.1093/cercor/bhw060. PubMed

Dahoun T, Trossbach SV, Brandon NJ, Korth C, Howes OD. The impact of Disrupted-in-Schizophrenia 1 (DISC1) on the dopaminergic system: a systematic review. Transl Psychiatry. 2017 Jan 31;7(1):e1015. doi: 10.1038/tp.2016.282. PubMed


Bader V, Trossbach SV, Prikulis I, Godsave SF, Peters PJ, Korth C. Misassembly of non-mutant full-length Disrupted-in-Schizophrenia 1 protein is induced by dopamine in vitro and in vivo. Mol Psychiatry. 2016 Nov;21(11):1487. doi: 10.1038/mp.2016.190. PubMed

Trossbach SV, Bader V, Hecher L, Pum ME, Masoud ST, Prikulis I, Schäble S, de Souza Silva MA, Su P, Boulat B, Chwiesko C, Poschmann G, Stühler K, Lohr KM, Stout KA, Oskamp A, Godsave SF, Müller-Schiffmann A, Bilzer T, Steiner H, Peters PJ, Bauer A, Sauvage M, Ramsey AJ, Miller GW, Liu F, Seeman P, Brandon NJ, Huston JP, Korth C. Misassembly of full-length Disrupted-in-Schizophrenia 1 protein is linked to altered dopamine homeostasis and behavioral deficits. Mol Psychiatry. 2016 Nov;21(11):1561-1572. doi: 10.1038/mp.2015.194. Epub 2016 Jan 12. PubMed

Hamburg H, Trossbach SV, Bader V, Chwiesko C, Kipar A, Sauvage M, Crum WR, Vernon AC, Bidmon HJ, Korth C. Simultaneous effects on parvalbumin-positive interneuron and dopaminergic system development in a transgenic rat model for sporadic schizophrenia. Sci Rep. 2016 Oct 10;6:34946. doi: 10.1038/srep34946. PubMed

Steffen J, Krohn M, Paarmann K, Schwitlick C, Brüning T, Marreiros R, Müller-Schiffmann A, Korth C, Braun K, Pahnke J. Revisiting rodent models: Octodon degus as Alzheimer's disease model? Acta Neuropathol Commun. 2016 Aug 26;4(1):91. doi: 10.1186/s40478-016-0363-y. PubMed 

Streich C, Akkari L, Decker C, Bormann J, Rehbock C, Müller-Schiffmann A, Niemeyer FC, Nagel-Steger L, Willbold D, Sacca B, Korth C, Schrader T, Barcikowski S. Characterizing the Effect of Multivalent Conjugates Composed of A?-Specific Ligands and Metal Nanoparticles on Neurotoxic Fibrillar Aggregation. ACS Nano. 2016 Aug 23;10(8):7582-97. doi: 10.1021/acsnano.6b02627. Epub 2016 Jul 20. PubMed

Requena JR, Kristensson K, Korth C, Zurzolo C, Simmons M, Aguilar-Calvo P, Aguzzi A, Andreoletti O, Benestad SL, Böhm R, Brown K, Calgua B, Del Río JA, Espinosa JC, Girones R, Godsave S, Hoelzle LE, Knittler MR, Kuhn F, Legname G, Laeven P, Mabbott N, Mitrova E, Müller-Schiffmann A, Nuvolone M, Peters PJ, Raeber A, Roth K, Schmitz M, Schroeder B, Sonati T, Stitz L, Taraboulos A, Torres JM, Yan ZX, Zerr I. The Priority position paper: Protecting Europe's food chain from prions. Prion. 2016 May 3;10(3):165-81. doi: 10.1080/19336896.2016.1175801. PubMed

Müller-Schiffmann A, Herring A, Abdel-Hafiz L, Chepkova AN, Schäble S, Wedel D, Horn AH, Sticht H, de Souza Silva MA, Gottmann K, Sergeeva OA, Huston JP, Keyvani K, Korth C. Amyloid-ß dimers in the absence of plaque pathology impair learning and synaptic plasticity. Brain. 2016 Feb;139(Pt 2):509-25. doi: 10.1093/brain/awv355. Epub 2015 Dec 10. PubMed

Storck SE, Meister S, Nahrath J, Meißner JN, Schubert N, Di Spiezio A, Baches S, Vandenbroucke RE, Bouter Y, Prikulis I, Korth C, Weggen S, Heimann A, Schwaninger M, Bayer TA, Pietrzik CU. Endothelial LRP1 transports amyloid-ß1-42 across the blood-brain barrier. J Clin Invest. 2016 Jan 4;126(1):123-36. doi: 10.1172/JCI81108. Epub 2015 Nov 30. PubMed 

Norkett R, Modi S, Birsa N, Atkin TA, Ivankovic D, Pathania M, Trossbach SV, Korth C, Hirst WD, Kittler JT. DISC1-dependent Regulation of Mitochondrial Dynamics Controls the Morphogenesis of Complex Neuronal Dendrites. J Biol Chem. 2016 Jan 8;291(2):613-29. doi: 10.1074/jbc.M115.699447. Epub 2015 Nov 9. PubMed


Rodríguez-Seoane C, Ramos A, Korth C, Requena JR. DISC1 regulates expression of the neurotrophin VGF through the PI3K/AKT/CREB pathway. J Neurochem. 2015 Nov;135(3):598-605. doi: 10.1111/jnc.13258. Epub 2015 Aug 12. PubMed

Marreiros R, Müller-Schiffmann A, Bader V, Selvarajah S, Dey D, Lingappa VR, Korth C. Viral capsid assembly as a model for protein aggregation diseases: Active processes catalyzed by cellular assembly machines comprising novel drug targets. Virus Res. 2015 Sep 2;207:155-64. doi: 10.1016/j.virusres.2014.10.003. Epub 2014 Oct 25. PubMed

Shahani N, Seshadri S, Jaaro-Peled H, Ishizuka K, Hirota-Tsuyada Y, Wang Q, Koga M, Sedlak TW, Korth C, Brandon NJ, Kamiya A, Subramaniam S, Tomoda T, Sawa A. DISC1 regulates trafficking and processing of APP and Aß generation. Mol Psychiatry. 2015 Jul;20(7):874-9. doi: 10.1038/mp.2014.100. Epub 2014 Sep 16. PubMed

Del Campo M, Oliveira CR, Scheper W, Zwart R, Korth C, Müller-Schiffmann A, Kostallas G, Biverstal H, Presto J, Johansson J, Hoozemans JJ, Pereira CF, Teunissen CE. BRI2 ectodomain affects Aß42 fibrillation and tau truncation in human neuroblastoma cells. Cell Mol Life Sci. 2015 Apr;72(8):1599-611. doi: 10.1007/s00018-014-1769-y. Epub 2014 Oct 22. PubMed

Ruocco LA, Treno C, Gironi Carnevale UA, Arra C, Boatto G, Pagano C, Tino A, Nieddu M, Michel M, Prikulis I, Carboni E, de Souza Silva MA, Huston JP, Sadile AG, Korth C. Immunization with DISC1 protein in an animal model of ADHD influences behavior and excitatory amino acids in prefrontal cortex and striatum. Amino Acids. 2015 Mar;47(3):637-50. doi: 10.1007/s00726-014-1897-6. Epub 2015 Jan 17. PubMed

Hellmert M, Müller-Schiffmann A, Peters MS, Korth C, Schrader T. Hybridization of an Aß-specific antibody fragment with aminopyrazole-based ß-sheet ligands displays striking enhancement of target affinity. Org Biomol Chem. 2015 Feb 24;13(10):2974-9. doi: 10.1039/c4ob02411g. PubMed


Korth C. Drug-induced hepatotoxicity of select herbal therapies. J Pharm Pract. 2014 Dec;27(6):567-72. doi: 10.1177/0897190014546117. PubMed

Trentini A, Comabella M, Tintoré M, Koel-Simmelink MJ, Killestein J, Roos B, Rovira A, Korth C, Ottis P, Blankenstein MA, Montalban X, Bellini T, Teunissen CE. N-Acetylaspartate and neurofilaments as biomarkers of axonal damage in patients with progressive forms of multiple sclerosis. J Neurol. 2014 Dec;261(12):2338-43. doi: 10.1007/s00415-014-7507-4. Epub 2014 Sep 17. PubMed

Trossbach SV, Fehsel K, Henning U, Winterer G, Luckhaus C, Schäble S, Silva MA, Korth C. Peripheral DISC1 protein levels as a trait marker for schizophrenia and modulating effects of nicotine. Behav Brain Res. 2014 Dec 15;275:176-82. doi: 10.1016/j.bbr.2014.08.064. Epub 2014 Sep 8. PubMed

Schmitz M, Greis C, Ottis P, Silva CJ, Schulz-Schaeffer WJ, Wrede A, Koppe K, Onisko B, Requena JR, Govindarajan N, Korth C, Fischer A, Zerr I. Loss of Prion Protein Leads to Age-Dependent Behavioral Abnormalities and Changes in Cytoskeletal Protein Expression. Mol Neurobiol. 2014 Dec;50(3):923-36. doi: 10.1007/s12035-014-8655-3. Epub 2014 Mar 7. PubMed

Ramos A, Rodríguez-Seoane C, Rosa I, Trossbach SV, Ortega-Alonso A, Tomppo L, Ekelund J, Veijola J, Järvelin MR, Alonso J, Veiga S, Sawa A, Hennah W, García A, Korth C, Requena JR. Neuropeptide precursor VGF is genetically associated with social anhedonia and underrepresented in the brain of major mental illness: its downregulation by DISC1. Hum Mol Genet. 2014 Nov 15;23(22):5859-65. doi: 10.1093/hmg/ddu303. Epub 2014 Jun 16. PubMed

Bradshaw NJ, Bader V, Prikulis I, Lueking A, Müllner S, Korth C. Aggregation of the Protein TRIOBP-1 and Its Potential Relevance to Schizophrenia. PLoS One. 2014 Oct 21;9(10):e111196. doi: 10.1371/journal.pone.0111196. eCollection 2014. PubMed

Trossbach SV, de Souza Silva MA, Huston JP, Korth C, Mattern C. Intranasal dopamine treatment reinstates object-place memory in aged rats. Neurobiol Learn Mem. 2014 Oct;114:231-5. doi: 10.1016/j.nlm.2014.07.006. Epub 2014 Jul 22. PubMed

Jarre A, Gowert NS, Donner L, Münzer P, Klier M, Borst O, Schaller M, Lang F, Korth C, Elvers M. Pre-activated blood platelets and a pro-thrombotic phenotype in APP23 mice modeling Alzheimer's disease. Cell Signal. 2014 Sep;26(9):2040-50. doi: 10.1016/j.cellsig.2014.05.019. Epub 2014 Jun 11. PubMed

Del Campo M, Hoozemans JJ, Dekkers LL, Rozemuller AJ, Korth C, Müller-Schiffmann A, Scheltens P, Blankenstein MA, Jimenez CR, Veerhuis R, Teunissen CE. BRI2-BRICHOS is increased in human amyloid plaques in early stages of Alzheimer's disease. Neurobiol Aging. 2014 Jul;35(7):1596-604. doi: 10.1016/j.neurobiolaging.2014.01.007. Epub 2014 Jan 13. PubMed

Wei J, Graziane NM, Wang H, Zhong P, Wang Q, Liu W, Hayashi-Takagi A, Korth C, Sawa A, Brandon NJ, Yan Z. (2014) Regulation of N-Methyl-D-Aspartate Receptors by Disrupted-in-Schizophrenia-1. Biol Psychiatry. 2014 Mar 1;75(5):414-24. doi: 10.1016/j.biopsych.2013.06.009. Epub 2013 Jul 29. PubMed

Rouvinski A, Karniely S, Kounin M, Moussa S, Goldberg MD, Warburg G, Lyakhovetsky R, Papy-Garcia D, Kutzsche J, Korth C, Carlson GA, Godsave SF, Peters PJ, Luhr K, Kristensson K, Taraboulos A. (2014) Live imaging of prions reveals nascent PrPSc in cell-surface, raft-associated amyloid strings and webs. J Cell Biol. Feb 3;204(3):423-41. doi: 10.1083/jcb.201308028. PubMed

Porteous DJ, Thomson PA, Millar JK, Evans KL, Hennah W, Soares DC, McCarthy S, McCombie WR, Clapcote SJ, Korth C, Brandon NJ, Sawa A, Kamiya A, Roder JC, Lawrie SM, McIntosh AM, St Clair D, Blackwood DH. (2014) DISC1 as a genetic risk factor for schizophrenia and related major mental illness: response to Sullivan. Mol Psychiatry. Feb;19(2):141-3. doi: 10.1038/mp.2013.160. PubMed

Koel-Simmelink MJ, Vennegoor A, Killestein J, Blankenstein MA, Norgren N, Korth C, Teunissen CE. (2014) The impact of pre-analytical variables on the stability of neurofilament proteins in CSF, determined by a novel validated SinglePlex Luminex assay and ELISA. J Immunol Methods. Jan 15;402(1-2):43-9. doi: 10.1016/j.jim.2013.11.008. Epub 2013 Nov 22. PubMed


Yerabham AS, Weiergräber OH, Bradshaw NJ, Korth C. (2013) Revisiting disrupted-in-schizophrenia 1 as a scaffold protein. Biol Chem. Nov 1;394(11):1425-37. doi: 10.1515/hsz-2013-0178. PubMed

Ottis P, Topic B, Loos M, Li KW, de Souza Silva MA, Schulz D, Smit AB, Huston JP, Korth C. (2013) Correction: Aging-Induced Proteostatic Changes in the Rat Hippocampus Identify ARP3, NEB2 and BRAG2 as a Molecular Circuitry for Cognitive Impairment. PLoS One. Oct 9;8(10). doi: 10.1371/annotation/2546f4c2-b07f-4450-8d3c-f3ee81127b4a. eCollection 2013. PubMed

Korth C, Klingenstein R, Müller-Schiffmann A. (2013) Hybrid molecules synergistically acting against protein aggregation diseases. Curr Top Med Chem. ;13(19):2484-90. PubMed

Vomund S, Sapir T, Reiner O, Silva MA, Korth C. (2013) Generation of topically transgenic rats by in utero electroporation and in vivo bioluminescence screening. J Vis Exp. Sep 24;(79):e50146. doi: 10.3791/50146. PubMed

Ottis P, Topic B, Loos M, Li KW, de Souza A, Schulz D, Smit AB, Huston JP, Korth C. (2013) Aging-induced proteostatic changes in the rat hippocampus identify ARP3, NEB2 and BRAG2 as a molecular circuitry for cognitive impairment. PLoS One. Sep 19;8(9):e75112. doi: 10.1371/journal.pone.0075112. eCollection 2013. PubMed

Verwey NA, Hoozemans JJ, Korth C, van Royen MR, Prikulis I, Wouters D, Twaalfhoven HA, van Haastert ES, Schenk D, Scheltens P, Rozemuller AJ, Blankenstein MA, Veerhuis R. (2013) Immunohistochemical characterization of novel monoclonal antibodies against the N-terminus of amyloid ß-peptide. Amyloid. Sep;20(3):179-87. doi: 10.3109/13506129.2013.797389. Epub 2013 Jul 5. PubMed

Dornieden S, Müller-Schiffmann A, Sticht H, Jiang N, Cinar Y, Wördehoff M, Korth C, Funke SA, Willbold D. (2013) Characterization of a single-chain variable fragment recognizing a linear epitope of aß: a biotechnical tool for studies on Alzheimer's disease? PLoS One. ;8(3):e59820. doi: 10.1371/journal.pone.0059820. Epub 2013 Mar 26. PubMed


Bader V, Tomppo L, Prikulis I, Leliveld SR, Lin CY, Sawa A, Ekelund J, Veijola J, Järvelin MR, Freimer N, Hennah W, Korth C. (2012) Proteomic, genomic and translational approaches identify CRMP1 for a role in schizophrenia and its underlying traits. Human Molecular Genetics, Oct 15;21(20):4406-18. Epub 2012 Jul 13. doi:10.1093/hmg/dds273. PubMed

Korth C (2012) Aggregated proteins in chronic mental diseases: DISC1opathies. Prion, 6:1-8. download

Korth C (2012) Identification of dominant human aquaporin 4 T cell epitopes – Observations in Neuromyelitis optica with implications for other autoimmune disorders. Archives of Neurology, Sep;69(9):1111-2. doi: 10.1001/archneurol.2012.1561. PubMed

Bader V, Ottis P, Pum M, Huston JP, Korth C. (2012) Generation, purification and characterization of cell-invasive DISC1 protein species. Journal of Visualized Experiments, Aug 30;(66):e4132. doi: 10.3791/4132. PubMed

Ottis P, Koppe K, Onisko B, Arzberger T, Kretzschmar H, Requena JR, Silva C, Huston JP, Korth C. (2012) Human and rat brain lipofuscin proteome. Proteomics doi: 10.1002/pmic.201100668. PubMed

Andreyeva A, Müller-Schiffmann A, Korth C, Gottmann K. C-terminal fragment of N-cadherin accelerates synapse destabilization by ?-amyloid. Brain 135:2140-54. PubMed

Müller-Schiffmann A, Sticht H, Korth C. (2012) Hybrid compounds - from simple combinations to nanomachines BioDrugs,26:21-31. PubMed

Giles K, De Nicola GF, Patel S, Korth C, Oehler A, DeArmond SJ, Prusiner SB. Identifying I137M and other mutations that modulate incubation periods for two human prion strains. (2012) Journal of Virology, 86:6033-41. PubMed

Pflanzner T, Petsch B, Andre-Dolmen B, Tschickardt S, Müller-Schiffmann A, Stitz L, Weggen S, Korth C, Pietrzik CU. (2012) Cellular prion protein participates in amyloid-beta transcytosis across the blood-brain barrier. Journal of Cerebral Blood Flow and Metabolism, 32:628-33. PubMed


Ottis P, Bader V, Trossbach S, Kretzschmar H, Michel M, Leliveld SR, Korth C. Convergence of two independent mental disease genes on the protein level: recruitment of dysbindin to cellinvasive DISC1 aggresomes. (2011) Biological Psychiatry 70:604-10. PubMed

Müller-Schiffmann A, Andreyeva A, Horn AHC, Gottmann K, Korth C*, Sticht H* (2011). Molecular engineering of a secreted, highly homogeneous, and neurotoxic aß dimer. ACS Chemical Neuroscience, cn-2011-00011h (epublished March 11, 2011) (*co-corresponding authors). PubMed

Schmidt C, Wolff M, Weitz M, Bartlau T, Korth C, Zerr I (2011) Rapidly progressive Alzheimer's disease. Archives of Neurology 68:1124-30. PubMed

Petsch B, Müller-Schiffmann A, Lehle A, Kuhn F, Bonilla W, Raeber A, Ironside J, Korth C, Stitz L. Biological effects and use of PrPSc- and PrP-specific antibodies generated by immunization with purified full-length native mouse prions. (2011). Journal of Virology 85:4538-46. PubMed

Meyer zu Hörste G, Mausberg AK, Müller JI, Lehmann HC, Löber S, Gmeiner P, Hartung HP, Stüve O, Korth C, Kieseier BC. Quinpramine ameliorates rat experimental autoimmune neuritis and redistributes MHC class II molecules. (2011) PLoS ONE, 6(6):e21223. PubMed

Stüve O, Wang J, Chan A, Hemmer B, Cepok S, Nessler S, Zipp F, Goldman MD, Meuth SG, Korth C, Lambracht-Washington D. No association between genetic polymorphism at codon 129 of the prion protein gene and primary progressive multiple sclerosis. (2011). Archives of Neurology, 68:264-265. PubMed

Hahn S, Brüning T, Ness J, Czirr E, Baches S, Gijsen H, Korth C, Pietrzik CU, Bulic B, Weggen S. Presenilin-1 but not amyloid precursor protein mutations present in mouse models of Alzheimer's disease attenuate the response of cultured cells to ?-secretase modulators regardless of their potency and structure. (2011). Journal of Neurochemistry, 116:385-95. PubMed


Müller-Schiffmann A, März J, Andreyeva A, Rönicke R, Bartnik D, Brener O, Kutzsche J, Horn AHC, Gottmann K, Reymann K, Funke SA, Nagel-Steger L, Moriscot C, Schoehn G, Sticht H, Willbold D, Schrader T, Korth C (2010). Combining independent drug classes into superior, synergistically acting hybrid molecules. Angewandte Chemie International Edition, 49:8743-46. PubMed

Seshadri S, Kamiya A, Yokota Y, Prikulis I, Kano SI, Hayashi-Takagi A, Stanco A, Rao S, Ishikuza K, Wong P, Korth C, Anton ES, Sawa A (2010). Disrupted-in-Schizophrenia-1 expression is regulated by beta-site amyloid precursor protein cleaving enzyme-1-neuregulin cascade. Proceedings of the National Academy of Sciences USA, 107: 5622-27. PubMed

Hu W, Nessler S, Hemmer B, Eager TN, Kane LP, Leliveld SR, Müller-Schiffmann A, Gocke AR, Lovett-Racke A, Ben LH, Hussain R, Breil A, Elliott JL, Carson P, Cravens PD, Singh MP, Petsch B, Stitz L, Racke MK, Korth C*, Stuve O* (*co-corresponding authors). (2010) Pharmacological PrP-Silencing Accelerates CNS Autoimmune Disease via TCR Signaling. Brain 133:375-388. PubMed

Meyer zur Hörste G, Mausberg AK, Korth C, Stüve O, Kieseier B. Quinpramine - a promising compound for treating immune-mediated demyelination of the nervous system. (2010) Drug News & Perspectives 23:287-94. PubMed

Giles K, Glidden DV, Patel S, Korth C, Groth D, Lemus A, DeArmond SJ, Prusiner SB (2010). Human prion strain selection in transgenic mice. Annals of Neurology 68:151-61. PubMed

Funke SA, van Groen T, Kadish I, Bartnik D, Nagel-Steger L, Brener O, Sehl T, Batra-Safferling R, Moriscot C, Schoehn G, Horn AHC, Müller-Schiffmann A, Korth C, Sticht H, Willbold D. Oral treatment with the d-enantiomeric peptide D3 improves the pathology and behavior of Alzheimer's Disease transgenic mice. (2010)  ACS Chemical Neuroscience 1: 639-48. PubMed

Schmitz M, Schlomm M, Mitrova E, Badrul H, Beekes M, Korth C, Carimalo J, Gawinecka J, Varges D, Zerr I. Codon 129 polymorphism and the E200K mutation do not affect the cellular prion protein isoform composition in the cerebrospinal fluid from patients with Creutzfeldt-Jakob disease. (2010) European Journal of Neuroscience 31:2024-31. PubMed

Lutz J, Brabeck C, Niemann HH, Kloz U, Korth C, Lingappa VR, Bürkle A. Microdeletions within the hydrophobic core region of the cellular prion protein alter its topology and metabolism (2010). Biochemical and Biophysical Research Communications 393:439-44. PubMed

Muyrers J, Klingenstein R, Stitz L, Korth C. Structure-activity relationship of tocopherol derivatives suggesting a novel non-antioxidant mechanism in antiprion potency. (2010) Neuroscience Letters 469:122-6. PubMed


Brandon N, Millar JK, Korth C, Sive H, Singh KK, Sawa A. Understanding the role of DISC1 in psychiatric disease and during normal development. (2009) Journal of Neuroscience, 29:12768-75 PubMed

Korth C. DISCopathies: brain disorders related to dysfunctional DISC1. (2009) Reviews in Neuroscience 20:321-330. download

Leliveld SR, Hendriks P, Michel M, Sajnani G, Bader V, Trossbach S, Prikulis I, Hartmann R, Jonas E, Willbold D, Requena JR, Korth C (2009) Oligomer assembly of the C-terminal DISC1 domain (640-854) is controlled by self-association motifs and disease-associated polymorphism S704C. Biochemistry, 48:7746-55. PubMed

Müller-Schiffmann A, Petsch B, Leliveld SR, Muyrers J, Salwierz A, Mangels C, Schwarzinger S, Riesner D, Stitz L, Korth C (2009). CComplementarity determining regions of an anti-prion protein scFv fragment orchestrate conformation specificity and antiprion activity. Molecular Immunology 46:532-40. PubMed

Jäger S, Leuchtenberger S, Martin A, Czirr E, Wesselowski J, Dieckmann M, Waldron E, Korth C, Koo EH, Heneka M, Weggen S, Pietrzik CU (2009). alpha-secretase mediated conversion of the Amyloid Precursor Protein derived membrane stub C99 to C83 limits Abeta generation. Journal of Neurochemistry 111:1369-82. PubMed

Mangels C, Frank AO, Ziegler J, Klingenstein R, Schweimer K, Willbold D, Korth C, Rösch P, Schwarzinger S (2009). Binding of tricyclic antiprion compounds to the prion protein: mechanism, implication for therapy, and application as probe for complex formation of bio-macromolecules. Journal of Biomolecular Structure & Dynamics 27:163-170. PubMed

Singh MP, Hörste GM, Hu W, Mausberg AK, Cravens P, Eager TN, Löber S, Klingenstein R, Gmeiner P, Korth C, Kieseier BC, Stüve O (2009). Quinpramine is a novel compound effective in ameliorating brain autoimmune disease. Experimental Neurology 215:397-400. PubMed

Stuve O*, Korth C*, Gabatto P, Cameron EM, Hu W, Eagar TN, Monson NL, Frohman EM, Racke MK, Zabetian CP, Oksenberg JR (2009). Genetic polymorphism at codon 129 of the prion protein is not associated with multiple sclerosis. Archives of Neurology 66:280-1. *joint first authorship PubMed


Leliveld SR, Bader V, Hendriks P, Prikulis I, Sajnani G, Requena J, Korth C (2008). Insolubility of DISC1 disrupts oligomer-dependent interactions with NDEL1 and is associated with sporadic mental disease. Journal of Neuroscience 28:3839-45.
Leliveld SR, Stitz L, Korth C (2008). Expansion of the octarepeat domain alters the misfolding pathway but not the folding pathway of the prion protein. Biochemistry 47:6267-78. PubMed

Tamgüney G, Giles K, Glidden DV, Lessard P, Wille H, Tremblay P, Groth DF, Yehiely F, Korth C, Moore RC, Tatzelt J, Rubenstein E, Boucheix C, Yang X, Stanley P, Lisanti MP, Dwek RA, Rudd PM, Moskovitz J, Epstein CJ, Dawson TC, Kuziel WA, Maeda N, Sap J, Hsiao Ashe K, Carlson GC, Tesseur I, Wyss-Coray T, Mucke L, Weisgraber KH, Mahley RW, Cohen FE, Prusiner SB (2008). Genes contributing to prion pathogenesis. Journal of General Virology 89:1777-88. PubMed

Müller-Schiffmann A & Korth C (2008) Vaccine approaches to prevent and treat prion infection: progress and challenges. BioDrugs 22:45-52. PubMed


Leliveld SR & Korth C (2007) The use of conformation-specific ligands and assays to dissect the molecular mechanisms of neurodegenerative diseases. Journal of Neuroscience Research 85:2285-2297. PubMed


Dollinger S, Löber S, Klingenstein R, Korth C, Gmeiner P. (2006) A Chimeric Ligand Approach Leading to Potent Anti-Prion Active Acridine Derivatives: Design, Synthesis and Biological Investigations. Journal of Medicinal Chemistry 49:6591-659. PubMed

Klingenstein R, Melnyk P, Leliveld SR, Rykebusch A, Korth C (2006) Similar structure-activity relationships of quinoline derivatives for antiprion and antimalarial effects. Journal of Medicinal Chemistry 49:5300-8. PubMed

Klingenstein R, Löber S, Kujala P, Godsave S, Leliveld SR, Gmeiner P, Peters P, Korth C (2006) Tricyclic antidepressants, quinacrine, and a novel, synthetic chimera thereof clear prions by destabilizing detergent-resistant membrane domains. Journal of Neurochemistry 98:748-759. PubMed

Korth C & Peters P (2006) Emerging pharmacotherapies for Creutzfeldt Jakob disease. Archives of Neurology 63(4):497-501. PubMed

Grubenbecher SG, Stuve O, Hefter H, Korth C (2006) Prion protein gene codon 129 modulates clinical course of neurological Wilson disease. Neuroreport 17:542-552. PubMed

Leliveld SR, Dame RT, Wuite G, Stitz L, Korth C (2006) The expanded octarepeat domain selectively binds prions and disrupts homomeric prion protein interactions. Journal of Biological Chemistry 281:3268-3275. PubMed


Korth C, Kaneko K, Groth D, Heye N, Telling G, Mastrianni J, Parchi P, Gambetti P, Will R, Ironside J, Heinrich C, Tremblay P, DeArmond S, Prusiner SB (2003) Abbreviated incubation times for human prions in mice expressing a chimeric mouse-human prion protein transgene. Proceedings of the National Academy of Sciences USA 100: 4784-88. PubMed

MediathekInformation und Wissen
LageplanSo finden Sie uns