Übersicht der Publikationen ab 2020

Hyaluronan synthase 3 deficiency lowers the incidence of ruptures of abdominal aortic aneurysms by reducing monocyte infiltration.

Magnetic resonance reveals early lipid deposition in murine prediabetes as predictive marker for cardiovascular injury.

Heller K, Flocke V, Straub T, Ding Z, Srivastava T, Nowak M, Funk F, Levkau B, Schmitt J, Grandoch M*, Flögel U*. NPJ Imaging 2024

Experimental TET2 Clonal Hematopoiesis Predisposes to Renal Hypertension Through an Inflammasome-Mediated Mechanism. 

Polizio AH, Marino L, Min KD, Yura Y, Rolauer L, Cochran JD, Evans MA, Park E, Doviak H, Miura-Yura E, Good ME, Wolpe AG, Grandoch M, Isakson B, Walsh K. Circ Res. 2024. doi: 10.1161 CIRCRESAHA.124.324492.

PMID: 39234670

GP VI-Mediated Platelet Activation and Procoagulant Activity Aggravate Inflammation and Aortic Wall Remodeling in Abdominal Aortic Aneurysm. 

Feige T, Bosbach A, Krott KJ, Mulorz J, Chatterjee M, Ortscheid J, Krüger E, Krüger I, Salehzadeh N, Goebel S, Ibing W, Grandoch M, Münch G, Wagenhäuser MU, Schelzig H, Elvers M. Arterioscler Thromb Vasc Biol. 2024. doi: 10.1161/ATVBAHA.123.320615.

PMID: 39206542

Ischemia does not provoke the full immune training repertoire in human cardiac fibroblasts. 

Mann C, van Alst C, Gorressen S, Nega R, Dobrev D, Grandoch M, Fender AC. Naunyn Schmiedebergs Arch Pharmacol. 2024. doi: 10.1007/s00210-024-03107-6. 

PMID: 38652279

The thrombin receptor PAR4 supports visceral adipose tissue inflammation. 

Kleeschulte S, Fischinger V, Öhlke L, Bode J, Kamler M, Dobrev D, Grandoch M, Fender AC. Naunyn Schmiedebergs Arch Pharmacol. 2024. doi: 10.1007/s00210-024-03097-5.

PMID: 38652276

Trained Innate Immunity in Animal Models of Cardiovascular Diseases. 

Kleimann P, Irschfeld LM, Grandoch M, Flögel U, Temme S. Int J Mol Sci. 2024. doi: 10.3390/ijms25042312. 

PMID: 38396989

Transformation or replacement - Effects of hormone therapy on cardiovascular risk. 

Kielb J, Saffak S, Weber J, Baensch L, Shahjerdi K, Celik A, Farahat N, Riek S, Chavez-Talavera O, Grandoch M, Polzin A, Kelm M, Dannenberg L. Pharmacol Ther. 2024. doi: 10.1016/j.pharmthera.2024.108592. 

PMID: 38286163

Noninvasive assessment of metabolic turnover during inflammation by in vivo deuterium magnetic resonance spectroscopy. 

Flocke V, Temme S, Bouvain P, Grandoch M, Flögel U. Front Immunol. 2023. doi: 10.3389/fimmu.2023.1258027.

PMID: 37841266

CD73 deficiency does not aggravate angiotensin II-induced aortic inflammation in mice. 

Massold T, Ibrahim F, Niemann V, Steckel B, Becker K, Schrader J, Stegbauer J, Temme S, Grandoch M, Flögel U, Bouvain P. Sci Rep. 2023. doi: 10.1038/s41598-023-44361-7. 

PMID: 37816827

Inhibition of hyaluronan synthesis prevents β-cell loss in obesity-associated type 2 diabetes. 

Nagy N, Kaber G, Sunkari VG, Marshall PL, Hargil A, Kuipers HF, Ishak HD, Bogdani M, Hull RL, Grandoch M, Fischer JW, McLaughlin TL, Wight TN, Bollyky PL. Matrix Biol. 2023. doi: 10.1016/j.matbio.2023.09.003.

PMID: 37783236

Non-invasive mapping of systemic neutrophil dynamics upon cardiovascular injury. Nat Cardiovasc Res (2023).

Pascal Bouvain, Zhaoping Ding, Shiwa Kadir, Patricia Kleimann, Nils Kluge, Zeynep-Büsra Tiren, Bodo Steckel, Vera Flocke, Ria Zalfen, Patrick Petzsch, Thorsten Wachtmeister, Gordon John, Nirojah Subramaniam, Wolfgang Krämer, Tobias Strasdeit, Mehrnaz Mehrabipour, Jens M. Moll, Rolf Schubert, Mohammad Reza Ahmadian, Florian Bönner, Udo Boeken, Ralf Westenfeld, Daniel Robert Engel, Malte Kelm, Jürgen Schrader, Karl Köhrer, Maria Grandoch, Sebastian Temme & Ulrich Flögel. Nat Cardiovasc Res (2023). doi: 10.1038/s44161-022-00210-w

In Vivo Mapping of Deep Tissue pO₂ in a Murine Model of Peripheral Artery Disease by Noninvasive ¹⁹F MR Relaxometry.

Stumpe N, Güden-Silber T, Schneckmann R, Wolters K, Lamb H, Grandoch M, Flögel U. Arterioscler Thromb Vasc Biol. 2023 Feb 9. doi: 10.1161/ATVBAHA.122.318548. Online ahead of print.

PMID: 36756882

Reduced secretion of neuronal growth regulator 1 contributes to impaired adipose-neuronal crosstalk in obesity.

Duregotti E, Reumiller CM, Mayr U, Hasman M, Schmidt LE, Burnap SA, Theofilatos K, Barallobre-Barreiro J, Beran A, Grandoch M, Viviano A, Jahangiri M, Mayr M. Nat Commun. 2022 Nov 25;13(1):7269. doi: 10.1038/s41467-022-34846-w.

PMID: 36433953 ­

Cardiomyocyte p38 MAPKα suppresses a heart-adipose tissue-neutrophil crosstalk in heart failure development.

Bottermann K, Kalfhues L, Nederlof R, Hemmers A, Leitner LM, Oenarto V, Nemmer J, Pfeffer M, Raje V, Deenen R, Petzsch P, Zabri H, Köhrer K, Reichert AS, Grandoch M, Fischer JW, Herebian D, Stegbauer J, Harris TE, Gödecke A.Basic Res Cardiol. 2022 Oct 7;117(1):48. doi: 10.1007/s00395-022-00955-2.

PMID: 36205817

Diabetes disturbs functional adaptation of the remote myocardium after ischemia/reperfusion.

Funk F, Kronenbitter A, Isić M, Flocke V, Gorreßen S, Semmler D, Brinkmann M, Beck K, Steinhoff O, Srivastava T, Barbosa DM, Voigt K, Wang L, Bottermann K, Kötter S, Grandoch M, Flögel U, Krüger M, Schmitt JP.J Mol Cell Cardiol. 2022 Sep 21;173:47-60. doi: 10.1016/j.yjmcc.2022.09.002. Online ahead of print.

PMID: 36150524

Red blood cell eNOS is cardioprotective in acute myocardial infarction.

Cortese-Krott MM, Suvorava T, Leo F, Heuser SK, LoBue A, Li J, Becher S, Schneckmann R, Srivrastava T, Erkens R, Wolff G, Schmitt JP, Grandoch M, Lundberg JO, Pernow J, Isakson BE, Weitzberg E, Kelm M.

Redox Biol. 2022 Aug;54:102370. doi: 10.1016/j.redox.2022.102370. Epub 2022 Jun 18.

PMID: 35759945 

Downregulation of eNOS and preserved endothelial function in endothelial-specific arginase 1-deficient mice.

Heuser SK, LoBue A, Li J, Zhuge Z, Leo F, Suvorava T, Olsson A, Schneckmann R, Guimaraes Braga DD, Srivrastava T, Montero L, Schmitz OJ, Schmitt JP, Grandoch M, Weitzberg E, Lundberg JO, Pernow J, Kelm M, Carlström M, Cortese-Krott MM.

Nitric Oxide. 2022 Aug 1;125-126:69-77. doi: 10.1016/j.niox.2022.06.004. Epub 2022 Jun 23.

PMID: 35752264

Multiparametric MRI identifies subtle adaptations for demarcation of disease transition in murine aortic valve stenosis.

Quast C, Kober F, Becker K, Zweck E, Hoffe J, Jacoby C, Flocke V, Gyamfi-Poku I, Keyser F, Piayda K, Erkens R, Niepmann S, Adam M, Baldus S, Zimmer S, Nickenig G, Grandoch M, Bönner F, Kelm M, Flögel U.

Basic Res Cardiol. 2022 May 29;117(1):29. doi: 10.1007/s00395-022-00936-5.

PMID: 35643805 

Toward Zero Variance in Proteomics Sample Preparation: Positive-Pressure FASP in 96-Well Format (PF96) Enables Highly Reproducible, Time- and Cost-Efficient Analysis of Sample Cohorts.

Loroch S, Kopczynski D, Schneider AC, Schumbrutzki C, Feldmann I, Panagiotidis E, Reinders Y, Sakson R, Solari FA, Vening A, Swieringa F, Heemskerk JWM, Grandoch M, Dandekar T, Sickmann A.

J Proteome Res. 2022 Apr 1;21(4):1181-1188. doi: 10.1021/acs.jproteome.1c00706. Epub 2022 Mar 22.

PMID: 35316605 

Protective Effects of Curcumin in Cardiovascular Diseases-Impact on Oxidative Stress and Mitochondria.

Cox FF, Misiou A, Vierkant A, Ale-Agha N, Grandoch M, Haendeler J, Altschmied J.

Cells. 2022 Jan 20;11(3):342. doi: 10.3390/cells11030342.

PMID: 35159155 

Factor Xa Inhibitors for Patients after Mechanical Heart Valve Replacement?

Gerfer S, Grandoch M, Wahlers TCW, Kuhn EW.

Thorac Cardiovasc Surg. 2021 Dec 11. doi: 10.1055/s-0041-1736242. Online ahead of print.

PMID: 34894638

The Proteoglycan Biglycan Modulates Platelet Adhesion and Thrombus Formation in a GPVI-Dependent Manner.

Hoermann H, Krueger I, Maurus N, Reusswig F, Sun Y, Kohlmorgen C, Grandoch M, Fischer JW, Elvers M.

Int J Mol Sci. 2021 Nov 10;22(22):12168. doi: 10.3390/ijms222212168.

PMID: 34830059 

Mitochondrial Telomerase Reverse Transcriptase Protects From Myocardial Ischemia/Reperfusion Injury by Improving Complex I Composition and Function.

Ale-Agha N, Jakobs P, Goy C, Zurek M, Rosen J, Dyballa-Rukes N, Metzger S, Greulich J, von Ameln F, Eckermann O, Unfried K, Brack F, Grandoch M, Thielmann M, Kamler M, Gedik N, Kleinbongard P, Heinen A, Heusch G, Gödecke A, Altschmied J, Haendeler J.

Circulation. 2021 Dec 7;144(23):1876-1890. doi: 10.1161/CIRCULATIONAHA.120.051923. Epub 2021 Oct 21.

PMID: 34672678

Multi-targeted ¹H/¹⁹F MRI unmasks specific danger patterns for emerging cardiovascular disorders.

Flögel U, Temme S, Jacoby C, Oerther T, Keul P, Flocke V, Wang X, Bönner F, Nienhaus F, Peter K, Schrader J, Grandoch M, Kelm M, Levkau B.

Nat Commun. 2021 Oct 6;12(1):5847. doi: 10.1038/s41467-021-26146-6.

PMID: 34615876 

Endothelial hyaluronan synthase 3 aggravates acute colitis in an experimental model of inflammatory bowel disease.

Hundhausen C, Schneckmann R, Ostendorf Y, Rimpler J, von Glinski A, Kohlmorgen C, Pasch N, Rolauer L, von Ameln F, Eckermann O, Altschmied J, Ale-Agha N, Haendeler J, Flögel U, Fischer JW, Grandoch M.

Matrix Biol. 2021 Aug;102:20-36. doi: 10.1016/j.matbio.2021.08.001. Epub 2021 Aug 28.

PMID: 34464693

Endothelial Hyaluronan Synthase 3 Augments Postischemic Arteriogenesis Through CD44/eNOS Signaling.

Schneckmann R, Suvorava T, Hundhausen C, Schuler D, Lorenz C, Freudenberger T, Kelm M, Fischer JW, Flögel U, Grandoch M.

Arterioscler Thromb Vasc Biol. 2021 Oct;41(10):2551-2562. doi: 10.1161/ATVBAHA.121.315478. Epub 2021 Aug 12.

PMID: 34380333

Red Blood Cell and Endothelial eNOS Independently Regulate Circulating Nitric Oxide Metabolites and Blood Pressure.

Leo F, Suvorava T, Heuser SK, Li J, LoBue A, Barbarino F, Piragine E, Schneckmann R, Hutzler B, Good ME, Fernandez BO, Vornholz L, Rogers S, Doctor A, Grandoch M, Stegbauer J, Weitzberg E, Feelisch M, Lundberg JO, Isakson BE, Kelm M, Cortese-Krott MM.

Circulation. 2021 Sep 14;144(11):870-889. doi: 10.1161/CIRCULATIONAHA.120.049606. Epub 2021 Jul 7.

PMID: 34229449 

Single-cell transcriptomics defines heterogeneity of epicardial cells and fibroblasts within the infarcted murine heart.

Hesse J, Owenier C, Lautwein T, Zalfen R, Weber JF, Ding Z, Alter C, Lang A, Grandoch M, Gerdes N, Fischer JW, Klau GW, Dieterich C, Köhrer K, Schrader J.

Elife. 2021 Jun 21;10:e65921. doi: 10.7554/eLife.65921.

PMID: 34152268 

Dapagliflozin reduces thrombin generation and platelet activation: implications for cardiovascular risk reduction in type 2 diabetes mellitus.

Kohlmorgen C, Gerfer S, Feldmann K, Twarock S, Hartwig S, Lehr S, Klier M, Krüger I, Helten C, Keul P, Kahl S, Polzin A, Elvers M, Flögel U, Kelm M, Levkau B, Roden M, Fischer JW, Grandoch M.

Diabetologia. 2021 Aug;64(8):1834-1849. doi: 10.1007/s00125-021-05498-0. Epub 2021 Jun 16.

PMID: 34131781 

4-Methylumbelliferone Attenuates Macrophage Invasion and Myocardial Remodeling in Pressure-Overloaded Mouse Hearts.

Hackert K, Homann S, Mir S, Beran A, Gorreßen S, Funk F, Fischer JW, Grandoch M, Schmitt JP.

Hypertension. 2021 Jun;77(6):1918-1927. doi: 10.1161/HYPERTENSIONAHA.120.15247. Epub 2021 Mar 22.

PMID: 33745300

Helix-Loop-Helix Factor Id3 (Inhibitor of Differentiation 3): A Novel Regulator of Hyaluronan-Mediated Adipose Tissue Inflammation.

Misiou A, Garmey JC, Hensien JM, Harmon DB, Osinski V, McSkimming C, Marshall MA, Fischer JW, Grandoch M, McNamara CA.

Arterioscler Thromb Vasc Biol. 2021 Feb;41(2):796-807. doi: 10.1161/ATVBAHA.120.315588. Epub 2020 Dec 31.

PMID: 33380173 

A novel mechanism of ACE inhibition-associated enhanced platelet reactivity: disproof of the ARB-MI paradox?

Helten C, Mourikis P, Dannenberg L, M'Pembele R, Trojovsky K, Ayhan A, Kohlmorgen C, Grandoch M, Levkau B, Veulemans V, Petzold T, Hohlfeld T, Kelm M, Zeus T, Polzin A.

Eur J Clin Pharmacol. 2020 Sep;76(9):1245-1251. doi: 10.1007/s00228-020-02915-y. Epub 2020 Jun 5.

PMID: 32500252