Drittmittelprojekte

H2020-EU.2.1.1, -
INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Information and Communication Technologies (ICT) Single molecule bio-electronic smart system array for clinical testing
European Commission - Cordis - SiMBiT 2019-2022  
DFG ES285/6-1,
Molekulare Charakterisierung von Vorläuferläsionen des Gallengangs-karzinoms 2016-2019
Else-Kröner-Fresenius-Stiftung
„Identifizierung von therapeutischen Vulnerabilitäten in einem aggressiven Pankreaskarzinom Subtyp“. 2016-2019
SFB974, Teilprojekt A18,
Funktionelle Relevanz der extrazellulären Matrixmoleküle Periostin und Tenascin C bei Leberschädigung und Regeneration. 2016-2019

Ausgewählte Publikationen

Haeberle L, Schramm M, Goering W, Frohn L, Driescher C, Hartwig W, Preissinger-Heinzel HK, Beyna T, Neuhaus H, Fuchs K, Keitel-Anselmino V, Knoefel WT, Esposito I.
Molecular analysis of cyst fluids improves the diagnostic accuracy of pre-operative assessment of pancreatic cystic lesions
Sci Rep. 2021 Feb 3;11(1):2901.
Driescher C*, Fuchs K*, Haeberle L, Goering W, Frohn L, Opitz FV, Haeussinger D, Knoefel WT, Keitel V, Esposito I.
Bile-Based Cell-Free DNA Analysis Is a Reliable Diagnostic Tool in Pancreatobiliary Cancer
Cancers (Basel). 2020 Dec 25;13(1):39. *Co-First Author
Schlitter AM, Segler A, Steiger K, Michalski CW, Jäger C, Konukiewitz B, Pfarr N, Endris V, Bettstetter M, Kong B, Regel I, Kleeff J, Klöppel G, Esposito I. 
Molecular, morphological and survival analysis of 177 resected pancreatic ductal adenocarcinomas (PDACs): Identification of prognostic subtypes
Sci Rep. 2017 Feb1;7:41064
Heid I, Steiger K, Trajkovic-Arsic M, Settles M, Eßwein MR, Erkan M, Kleeff J,Jäger C, Friess H, Haller B, Steingötter A, Schmid RM, Schwaiger M, Rummeny EJ, Esposito I*, Siveke JT*, 
Braren R*. 
Co-clinical assessment of tumor cellularity in pancreatic cancer
Clin Cancer Res. 2016 Sep 23. *Senior authors
Wirth M, Mahboobi S, Krämer OH, Schneider G. 
Concepts to Target MYC in Pancreatic Cancer
Mol Cancer Ther. 2016 Aug;15(8):1792-8
Mazur PK, Herner A, Mello SS, Wirth M, Hausmann S, Sánchez-Rivera FJ, Lofgren SM, Kuschma T, Hahn SA, Vangala D, Trajkovic-Arsic M, Gupta A, Heid I, Noël PB, Braren R, Erkan M, Kleeff J, Sipos B, Sayles LC, Heikenwalder M, Heßmann E, Ellenrieder V, Esposito I, Jacks T, Bradner JE, Khatri P, Sweet-Cordero EA, Attardi LD, Schmid RM, Schneider G, Sage J, Siveke JT. 
Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma
Nat Med. 2015 Oct;21(10):1163-71
Berchtold S, Grünwald B, Krüger A, Reithmeier A, Hähl T, Cheng T, Feuchtinger A, Born D, Erkan M, Kleeff J, Esposito I. 
Collagen type V promotes the malignant phenotype of pancreatic ductal adenocarcinoma
Cancer Lett. 2015 Jan 28;356(2 Pt B):721-32
Wirth M, Schneider G. 
MYC: A Stratification Marker for Pancreatic Cancer Therapy
Trends in Cancer. 2015 Dec 19
Diersch S*, Wirth M*, Schneeweis C*, Jörs S, Geisler F, Siveke JT, Rad R, Schmid RM, Saur D, Rustgi AK, Reichert M, Schneider G.
KrasG12D induces EGFR-MYC cross signaling in murine primary pancreatic ductal epithelial cells
Oncogene. 2015 Nov 23.*Co-First Author
Schlitter AM, Born D, Bettstetter M, Specht K, Kim-Fuchs K, Riener M, Jeliazkova P, Sipos B, Siveke JT, Terris B, Zen Y, Schuster T, Höfler H, Perren A, Klöppel G, Esposito I. 
Intraductal papillary neoplasms of the bile duct: stepwise progression to carcinoma involves common molecular pathways
Mod Pathol 2014 Jan;27(1):73-86
Wirth M, Stojanovic N, Christian J, Paul MC, Stauber RH, Schmid RM, Häcker G, Krämer OH, Saur D, Schneider G. 
MYC and EGR1 synergize to trigger tumor cell death by controlling NOXA and BIM transcription upon treatment with the proteasome inhibitor bortezomib
Nucleic Acids Res. 2014;42(16):10433-47
Aichler M, Seiler C, Tost M, Siveke J, Mazur PK, Da Silva-Buttkus P, Bartsch DK, Langer P, Chiblak S, Dürr A, Höfler H, Klöppel G, Müller-Decker K, Brielmeier M, Esposito I.
Origin of pancreatic ductal adenocarcinoma from atypical flat lesions:
a comparative study in transgenic mice and human tissues

J Pathol. 2012 Apr;226(5):723-34

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