Drittmittelprojekte |
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| DFG Genotype-phenotype correlation in pancreaticobiliary cancers and their precursor lesions. 2022 – 2025 |
| Brigitte und Dr. Konstanze Wegener-Stiftung Integration of imaging and histopathological data for the evaluation of therapy response in neoadjuvant treated pancreatic ductal adenocarcinoma. 2023 – 2025 |
| BMBF PRECISE-MD-Pancreatic Ductal Adenocarcinoma and Hepatocellular Carcinoma: Advancing Diagnostic Strategies through Multicenter Data Integration and Biomarker Development. 2024 – 2026 |
| German Cancer Aid National network genomic medicine (nNGM) lung cancer: Network of the German oncology centers of excellence for precision medicine in lung cancer. Fourth funding period. 2024 – 2027 |
Ausgewählte Publikationen |
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| Schlensog M, Ruehlmann AC, Haeberle L, Opitz F, Becher AK, Goering W, Buth J, Knoefel WT, Ladage D, Meyer A, Esposito I. Tenascin-C affects invasiveness of EGFR-mutated lung adenocarcinoma through a putative paracrine loop. Biochim Biophys Acta Mol Basis Dis. 2023 Jun;1869(5):166684. |
| Liffers ST, Godfrey L, Frohn L, Haeberle L, Yavas A, Vesce R, Goering W, Opitz FV, Stoecklein N, Knoefel WT, Schlitter AM, Klöppel G, Espinet E, Trumpp A, Siveke JT, Esposito I. Molecular heterogeneity and commonalities in pancreatic cancer precursors with gastric and intestinal phenotype. Gut. 2023 Mar;72(3):522-534. |
| Opitz FV, Haeberle L, Daum A, Esposito I. Tumor Microenvironment in Pancreatic Intraepithelial Neoplasia. Cancers (Basel). 2021 Dec 8;13(24):6188. |
| Haeberle L, Schramm M, Goering W, Frohn L, Driescher C, Hartwig W, Preissinger-Heinzel HK, Beyna T, Neuhaus H, Fuchs K, Keitel-Anselmino V, Knoefel WT, Esposito I. Molecular analysis of cyst fluids improves the diagnostic accuracy of pre-operative assessment of pancreatic cystic lesions Sci Rep. 2021 Feb 3;11(1):2901. |
| Driescher C*, Fuchs K*, Haeberle L, Goering W, Frohn L, Opitz FV, Haeussinger D, Knoefel WT, Keitel V, Esposito I. Bile-Based Cell-Free DNA Analysis Is a Reliable Diagnostic Tool in Pancreatobiliary Cancer Cancers (Basel). 2020 Dec 25;13(1):39. *Co-First Author |
| Schlitter AM, Segler A, Steiger K, Michalski CW, Jäger C, Konukiewitz B, Pfarr N, Endris V, Bettstetter M, Kong B, Regel I, Kleeff J, Klöppel G, Esposito I. Molecular, morphological and survival analysis of 177 resected pancreatic ductal adenocarcinomas (PDACs): Identification of prognostic subtypes Sci Rep. 2017 Feb1;7:41064 |
| Heid I, Steiger K, Trajkovic-Arsic M, Settles M, Eßwein MR, Erkan M, Kleeff J,Jäger C, Friess H, Haller B, Steingötter A, Schmid RM, Schwaiger M, Rummeny EJ, Esposito I*, Siveke JT*, Braren R*. Co-clinical assessment of tumor cellularity in pancreatic cancer Clin Cancer Res. 2016 Sep 23. *Senior authors |
| Wirth M, Mahboobi S, Krämer OH, Schneider G. Concepts to Target MYC in Pancreatic Cancer Mol Cancer Ther. 2016 Aug;15(8):1792-8 |
| Mazur PK, Herner A, Mello SS, Wirth M, Hausmann S, Sánchez-Rivera FJ, Lofgren SM, Kuschma T, Hahn SA, Vangala D, Trajkovic-Arsic M, Gupta A, Heid I, Noël PB, Braren R, Erkan M, Kleeff J, Sipos B, Sayles LC, Heikenwalder M, Heßmann E, Ellenrieder V, Esposito I, Jacks T, Bradner JE, Khatri P, Sweet-Cordero EA, Attardi LD, Schmid RM, Schneider G, Sage J, Siveke JT. Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma Nat Med. 2015 Oct;21(10):1163-71 |
| Berchtold S, Grünwald B, Krüger A, Reithmeier A, Hähl T, Cheng T, Feuchtinger A, Born D, Erkan M, Kleeff J, Esposito I. Collagen type V promotes the malignant phenotype of pancreatic ductal adenocarcinoma Cancer Lett. 2015 Jan 28;356(2 Pt B):721-32 |
| Wirth M, Schneider G. MYC: A Stratification Marker for Pancreatic Cancer Therapy Trends in Cancer. 2015 Dec 19 |
| Diersch S*, Wirth M*, Schneeweis C*, Jörs S, Geisler F, Siveke JT, Rad R, Schmid RM, Saur D, Rustgi AK, Reichert M, Schneider G. KrasG12D induces EGFR-MYC cross signaling in murine primary pancreatic ductal epithelial cells Oncogene. 2015 Nov 23.*Co-First Author |
| Schlitter AM, Born D, Bettstetter M, Specht K, Kim-Fuchs K, Riener M, Jeliazkova P, Sipos B, Siveke JT, Terris B, Zen Y, Schuster T, Höfler H, Perren A, Klöppel G, Esposito I. Intraductal papillary neoplasms of the bile duct: stepwise progression to carcinoma involves common molecular pathways Mod Pathol 2014 Jan;27(1):73-86 |
| Wirth M, Stojanovic N, Christian J, Paul MC, Stauber RH, Schmid RM, Häcker G, Krämer OH, Saur D, Schneider G. MYC and EGR1 synergize to trigger tumor cell death by controlling NOXA and BIM transcription upon treatment with the proteasome inhibitor bortezomib Nucleic Acids Res. 2014;42(16):10433-47 |
| Aichler M, Seiler C, Tost M, Siveke J, Mazur PK, Da Silva-Buttkus P, Bartsch DK, Langer P, Chiblak S, Dürr A, Höfler H, Klöppel G, Müller-Decker K, Brielmeier M, Esposito I. Origin of pancreatic ductal adenocarcinoma from atypical flat lesions: a comparative study in transgenic mice and human tissues J Pathol. 2012 Apr;226(5):723-34 |