Free Bilirubin Induces Neuro-Inflammation in an Induced Pluripotent Stem Cell-Derived Cortical Organoid Model of Crigler-Najjar Syndrome.
Pranty AI, Wruck W, Adjaye J.
Cells. 2023 Sep 14;12(18):2277. doi: 10.3390/cells12182277. Weblink

JNK Signalling Regulates Self-Renewal of Proliferative Urine-Derived Renal Progenitor Cells via Inhibition of Ferroptosis.
Nguyen L, Thewes L, Westerhoff M, Wruck W, Reichert AS, Berndt C, Adjaye J.
Cells. 2023 Sep 2;12(17):2197. doi: 10.3390/cells12172197. Weblink

Natural Products in Renal-Associated Drug Discovery.
Wruck W, Genfi AKA, Adjaye J.
Antioxidants (Basel). 2023 Aug 11;12(8):1599. doi: 10.3390/antiox12081599. Weblink

Unveiling Angiotensin II and Losartan-Induced Gene Regulatory Networks Using Human Urine-Derived Podocytes.
Thimm C, Erichsen L, Wruck W, Adjaye J.
Int J Mol Sci. 2023 Jun 23;24(13):10551. doi: 10.3390/ijms241310551. Weblink

Generation of two Alpha-I Antitrypsin Deficiency patient-derived induced pluripotent stem cell lines ISRM-AATD-iPSC-1 (HHUUKDi011-A) and ISRM-AATD-iPSC-2 (HHUUKDi012-A).
Ncube A, Bewersdorf L, Spitzhorn LS, Lörch C, Bohndorf M, Graffmann N, May L, Amzou S, Fromme M, Wruck W, Strnad P, Adjaye J.
Stem Cell Research, 2023, 103171, ISSN 1873-5061, Weblink

Secreted Cytokines within the Urine of AKI Patients Modulate TP53 and SIRT1 Levels in a Human Podocyte Cell Model.
Erichsen L, Thimm C, Wruck W, Kaierle D, Schless M, Huthmann L, Dimski T, Kindgen-Milles D, Brandenburger T, Adjaye J.
Int J Mol Sci. 2023 May 4;24(9):8228. doi: 10.3390/ijms24098228. Weblink

Derivation of the Immortalized Cell Line UM51-PrePodo-hTERT and Its Responsiveness to Angiotensin II and Activation of the RAAS Pathway.
Erichsen L, Kloss LDF, Thimm C, Bohndorf M, Schichel K, Wruck W, Adjaye J.
Cells. 2023 Jan 17;12(3):342. doi: 10.3390/cells12030342. Weblink

Urine-Based Detection of Biomarkers Indicative of Chronic Kidney Disease in a Patient Cohort from Ghana.
Wruck W, Boima V, Erichsen L, Thimm C, Koranteng T, Kwakyi E, Antwi S, Adu D, Adjaye J.
J Pers Med. 2022 Dec 24;13(1):38. doi: 10.3390/jpm13010038. Weblink

Gene expression studies of WT1 mutant Wilms tumor cell lines in the frame work of published kidney development data reveals their early kidney stem cell origin.
Royer-Pokora B, Wruck W, Adjaye J, Beier M.
PLoS One. 2023 Jan 23;18(1):e0270380. doi: 10.1371/journal.pone.0270380. eCollection 2023. Weblink



Editorial for Special Issue: iPS Cells (iPSCs) for Modelling and Treatment of Human Diseases.
Graffmann N, Adjaye J.
Cells. 2022 Jul 22;11(15):2270. doi: 10.3390/cells11152270. Weblink

In vitro differentiation of pluripotent stem cells into hepatocyte like cells - Basic principles and current progress.
Graffmann N, Scherer B, Adjaye J.
Stem Cell Res. 2022 May;61:102763. doi: 10.1016/j.scr.2022.102763. Epub 2022 Mar 24. Weblink

Crosstalk between age accumulated DNA-damage and the SIRT1-AKT-GSK3ß axis in urine derived renal progenitor cells.
Erichsen L, Adjaye J.
Aging (Albany NY). 2022 Sep 24;14(20):8179-8204. doi: 10.18632/aging.204300. Epub 2022 Sep 24. Weblink

Detailed Characterization of Small Extracellular Vesicles from Different Cell Types Based on Tetraspanin Composition by ExoView R100 Platform
Breitwieser K, Koch LF, Tertel T, Proestler E, Burgers LD, Lipps C, Adjaye J, Fürst R, Giebel B, Saul MJ.
Int J Mol Sci. 2022 Aug; 23(15): 8544. Published online 2022 Aug 1. doi: 10.3390/ijms23158544 Weblink

Bilirubin-Induced Neurological Damage: Current and Emerging iPSC-Derived Brain Organoid Models
Pranty AI, Shumka S and Adjaye J.
Cells 2022, 11,2647. Weblink

Activation of the Renin–Angiotensin System Disrupts the Cytoskeletal Architecture of Human Urine-Derived Podocytes.
Erichsen L, Thimm C, Bohndorf M, Rahman MS, Wruck W and Adjaye J.
Cells 2022, 11(7), 1095; Weblink

Impaired p53-Mediated DNA Damage Response Contributes to Microcephaly in Nijmegen Breakage Syndrome Patient-Derived Cerebral Organoids.
Martins S, Erichsen L, Datsi A, Wruck W, Goering W, Chatzantonaki E, Meira de Amorim VC, Rossi A, Chrzanowska KH and Adjaye J.
Cells 2022, 11(5), 802; Weblink

The Nephrotoxin Puromycin Aminonucleoside Induces Injury in Kidney Organoids Differentiated from Induced Pluripotent Stem Cells.
Nguyen L, Wruck W, Erichsen L, Graffmann N, Adjaye J.
Cells 2022 Feb 11;11(4):635. doi: 10.3390/cells11040635. Weblink



Detailed phylogenetic analysis tracks transmission of distinct SARS-COV-2 variants from China and Europe to West Africa.
Wruck W, Adjaye J.
Sci Rep. 2021 Oct 26;11(1):21108. doi: 10.1038/s41598-021-00267-w. Weblink

Transcriptome-based analysis of blood samples reveals elevation of DNA damage response, neutrophil degranulation, cancer and neurodegenerative pathways in Plasmodium falciparum patients
Karikari AA, Wruck W, Adjaye J.
Malar J. 2021 Sep 26;20(1):383. doi: 10.1186/s12936-021-03918-5. Weblink

Human Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Acquire Rejuvenation and Reduced Heterogeneity.
Wruck W, Graffmann N, Spitzhorn LS and Adjaye J.
Front. Cell Dev. Biol.,2021;9:2481. Epub 16 September 2021; doi: Weblink

Angiotensin II disrupts the cytoskeletal architecture of human urine-derived podocytes and results in activation of the renin-angiotensin system.
Erichsen L, Bohndorf M, Rahman MS, Wruck W, Adjaye J.
bioRxiv 2021.03.18.436037; doi: Weblink

Generation of a Crigler-Najjar Syndrome Type I patient-derived induced pluripotent stem cell line CNS705 (HHUUKDi005-A).
Graffmann N, Martins S, Ljubikj T, Matte JC, Bohndorf M, Wruck W, Adjaye J.
Stem Cell Res. 2021 Jan 12;51:102167. doi: 10.1016/j.scr.2021.102167. Online ahead of print. Weblink

The pioneer and differentiation factor FOXA2 is a key driver of yolk-sac tumour formation and a new biomarker for paediatric and adult yolk-sac tumours.
Wruck W, Bremmer F, Kotthoff M, Fichtner A, Skowron MA, Schönberger S, Calaminus G, Vokuhl C, Pfister D, Heidenreich A, Albers P, Adjaye J, Nettersheim D.
J Cell Mol Med. 2021 Jan 14. doi: 10.1111/jcmm.16222. Online ahead of print. Weblink


A stem cell based in vitro model of NAFLD enables the analysis of patient specific individual metabolic adaptations in response to a high fat diet and AdipoRon interference.
Graffmann N, Ncube A, Martins S, Fiszl AR, Reuther P, Bohndorf M, Wruck W, Beller M, Czekelius C, Adjaye J.
Biol Open. 2020 Dec 28:bio.054189. doi: 10.1242/bio.054189. Online ahead of print. Weblink

SARS-CoV-2 receptor ACE2 is co-expressed with genes related to transmembrane serine proteases, viral entry, immunity and cellular stress.
Wruck W, Adjaye J.
Sci Rep. 2020 Dec 8;10(1):21415. doi: 10.1038/s41598-020-78402-2. Weblink

Secretome Analysis of Mesenchymal Stem Cell Factors Fostering Oligodendroglial Differentiation of Neural Stem Cells In Vivo.
Samper Agrelo I, Schira-Heinen J, Beyer F, Groh J, Bütermann C, Estrada V, Poschmann G, Bribian A, Jadasz JJ, Lopez-Mascaraque L, Kremer D, Martini R, Müller HW, Hartung HP, Adjaye J, Stühler K, Küry P.
Int J Mol Sci. 2020 Jun 18;21(12):4350. doi: 10.3390/ijms21124350. Weblink

Matrix Metalloproteinase 14 Mediates APP Proteolysis and Lysosomal Alterations Induced by Oxidative Stress in Human Neuronal Cells.
Llorente P, Martins S, Sastre I, Aldudo J, Recuero M, Adjaye J, Bullido MJ.
Oxid Med Cell Longev. 2020 Nov 16;2020:5917187. doi: 10.1155/2020/5917187. eCollection 2020. Weblink

IPSC-Derived Neuronal Cultures Carrying the Alzheimer's Disease Associated TREM2 R47H Variant Enables the Construction of an Aβ-Induced Gene Regulatory Network.
Martins S, Müller-Schiffmann A, Erichsen L, Bohndorf M, Wruck W, Sleegers K, Van Broeckhoven C, Korth C, Adjaye J.
Int J Mol Sci. 2020 Jun 25;21(12):E4516. doi: 10.3390/ijms21124516. Weblink

Meta-analysis of transcriptomes of SARS-Cov2 infected human lung epithelial cells identifies transmembrane serine proteases co-expressed with ACE2 and biological processes related to viral entry, immunity, inflammation and cellular stress.
Wruck W, Adjaye J.
bioRxiv 2020.05.12.091314; doi:

AP-2 reduces amyloidogenesis by promoting BACE1 trafficking and degradation in neurons.
Bera S, Camblor-Perujo S, Calleja Barca E, Negrete-Hurtado A, Racho J, De Bruyckere E, Wittich C, Ellrich N, Martins S, Adjaye J, Kononenko NL.
EMBO Rep. 2020 Apr 23:e47954. doi: 10.15252/embr.201947954. [Epub ahead of print] Weblink

Transcriptomic analysis of marine endophytic fungi extract identifies highly enriched anti-fungal fractions targeting cancer pathways in HepG2 cell lines
Blessie EJ, Wruck W, Abbey BA, Ncube A, Graffmann N, Amarh V, Arthur PK and Adjaye J
BMC Genomics (2020) 21:265 Weblink

Characterization and application of electrically active neuronal networks established from human induced pluripotent stem cell-derived neural progenitor cells for neurotoxicity evaluation
Nimtz L, Hartmann J, Tigges J, Masjosthusmann S, Schmuck M, Keßel E, Theiss S, Köhrer K, Petzsch P, Adjaye J, Wigmann C, Wieczorek DHildebrandt B, Bendt F, Hübenthala U, Brockerhoff G, Fritsche E.
Stem Cell Research Volume 45, May 2020, 101761 Weblink

Meta-analysis of human prefrontal cortex reveals activation of GFAP and decline of synaptic transmission in the aging brain.
Wruck W, Adjaye J.
Acta Neuropathol Commun. 2020 Mar 5;8(1):26. doi: 10.1186/s40478-020-00907-8. Weblink

Functional omics analyses reveal only minor effects of microRNAs on human somatic stem cell differentiation.
Schira-Heinen J, Czapla A, Hendricks M, Kloetgen A, Wruck W, Adjaye J, Kögler G, Werner Müller H, Stühler K, Trompeter HI.
Sci Rep. 2020 Feb 24;10(1):3284. doi: 10.1038/s41598-020-60065-8. Weblink

The FGF, TGFβ and WNT axis Modulate Self-renewal of Human SIX2+ Urine Derived Renal Progenitor Cells.
Rahman MS, Wruck W, Spitzhorn LS, Nguyen L, Bohndorf M, Martins S, Asar F, Ncube A, Erichsen L, Graffmann N, Adjaye J.
Sci Rep. 2020 Jan 20;10(1):739. doi: 10.1038/s41598-020-57723-2 WeblinkPress release  AAAS EurekAlert ScienceNews

Liver Disease Modelling
Graffmann N., Spitzhorn LS., Ncube A., Wruck W., Adjaye J. (2020)
In: Brand-Saberi B. (eds) Essential Current Concepts in Stem Cell Biology. Learning Materials in Biosciences. Springer, Cham Weblink

Stem Cell Therapy
Graffmann N., Spitzhorn LS., Martins S., Rahman M.S., Nguyen L., Adjaye J. (2020)
In: Hock F., Gralinski M. (eds) Drug Discovery and Evaluation: Methods in Clinical Pharmacology. Springer, Cham Weblink


FGF Signalling in the Self-Renewal of Colon Cancer Organoids.
Otte J, Dizdar L, Behrens B, Goering W, Knoefel WT, Wruck W, Stoecklein NH, Adjaye J.
Sci Rep. 2019 Nov 22;9(1):17365. doi: 10.1038/s41598-019-53907-7. Weblink

Human iPSC-derived iMSCs improve bone regeneration in mini-pigs
Jungbluth P, Spitzhorn LS, Grassmann J, Tanner S, Latz D, Rahman MS, Bohndorf M, Wruck W, Sager M, Grotheer V, Kröpil P, Hakimi M, Windolf J, Schneppendahl J & Adjaye J.
Bone Research volume 7, Article number: 32 (2019) Weblink

Constructing an Isogenic 3D Human Nephrogenic Progenitor Cell Model Composed of Endothelial, Mesenchymal, and SIX2-Positive Renal Progenitor Cells
Nguyen L, Spitzhorn LS and Adjaye J.
Stem Cells International Volume 2019, Article ID 3298432, 11 pages.

Characterization of burn wound healing gel prepared from human amniotic membrane and Aloe vera extract.
Rahman MS, Islam R, Rana MM, Spitzhorn LS, Rahman MS, Adjaye J, Asaduzzaman SM.
BMC Complement Altern Med. 2019 Jun 3;19(1):115. doi: 10.1186/s12906-019-2525-5. Weblink

Human mid-trimester amniotic fluid (stem) cells lack expression of the pluripotency marker OCT4A.
Vlahova F, Hawkins KE, Ranzoni AM, Hau KL, Sagar R, Coppi P, David AL, Adjaye J, Guillot PV.
Sci Rep. 2019 May 31;9(1):8126. doi: 10.1038/s41598-019-44572-x. Weblink

Fabrication of biocompatible porous scaffolds based on hydroxyapatite/collagen/chitosan composite for restoration of defected maxillofacial mandible bone.
Rahman MS, Rana MM, Spitzhorn LS, Akhtar N, Hasan MZ, Choudhury N, Fehm T, Czernuszka JT, Adjaye J, Asaduzzaman SM.
Prog Biomater. 2019 May 29. doi: 10.1007/s40204-019-0113-x. [Epub ahead of print] Weblink

The quest for pluripotency: a comparative analysis across mammalian species.
Devika AS, Wruck W, Adjaye J, Sudheer S.
Reproduction. 2019 Apr 1. pii: REP-18-0083.R4. doi: 10.1530/REP-18-0083. [Epub ahead of print] Review. Weblink

Human iPSC-derived MSCs (iMSCs) from aged individuals acquire a rejuvenation signature
Spitzhorn LS, Megges M, Wruck W, Rahman MS, Otte J, Degistirici Ö, Meisel R, Sorg RV, Oreffo ROC and Adjaye J.
Stem Cell Research & Therapy 2019 10:100. doi: Weblink, Press Release, Stem cell network NRW, AAAS EurekAlert Science News

Imidazopyridines as potent KDM5 demethylase inhibitors promoting reprogramming efficiency of human induced pluripotent stem cells
Dabiri Y, Gama-Brambila RA, Taškova K, Herold K, Reuter S, Adjaye J, Utikal J, Mrowka R, Wang J,Andrade-Navarro MA,Cheng X.
iScience. 2019. doi: Weblink



Fibroblast-derived integration-free iPSC line ISRM-NBS1 from an 18-year-old Nijmegen Breakage Syndrome patient carrying the homozygous NBN c.657_661del5 mutation.
Martins S, Bohndorf M, Graffmann N, Wruck W, Chrzanowska KH, Adjaye J.
Stem Cell Res. 2018 Dec 27;34:101372. doi: 10.1016/j.scr.2018.101372. [Epub ahead of print] Weblink

Gene expression profiling in aggressive digital papillary adenocarcinoma sheds light on the architecture of a rare sweat gland carcinoma.
Surowy HM, Giesen AK, Otte J, Büttner R, Falkenstein D, Friedl H, Meier F, Petzsch P, Wachtmeister T, Westphal D, Wieczorek D, Wruck W, Adjaye J, Rütten A, Redler S.
Br J Dermatol. 2018 Nov 25. doi: 10.1111/bjd.17446. [Epub ahead of print] Weblink

Molecular Phenotyping of Telomerized Human Bone Marrow Skeletal Stem Cells Reveals a Genetic Program of Enhanced Proliferation and Maintenance of Differentiation Responses.
Twine NA, Harkness L, Adjaye J, Aldahmash A, Wilkins MR, Kassem M.
JBMR Plus. 2018 May 24;2(5):257-267. doi: 10.1002/jbm4.10050. eCollection 2018 Sep Weblink

Transplanted human pluripotent stem cell-derived mesenchymal stem cells support liver regeneration in Gunn rats.
Spitzhorn LS, Kordes C, Megges M, Sawitza I, Götze S, Reichert D, Schulze-Matz P, Graffmann N, Bohndorf M, Wruck W, Köhler JP, Herebian D, Mayatepek E, Oreffo RO, Häussinger D, Adjaye J.
Stem Cells Dev. 2018 Oct 3. doi: 10.1089/scd.2018.0010. [Epub ahead of print] Weblink

Establishment and characterization of an iPSC line from a 35 years old high grade patient with nonalcoholic fatty liver disease (30–40% steatosis) with homozygous wildtype PNPLA3 genotype
Graffmann N, Bohndorf M, Ncube A, Kawala MA, Wruck W, Kashofer K, Zatloukal K, Adjaye J.
Stem Cell Research. 2018 doi: 10.1016/j.scr.2018.07.015 Weblink

Cell fate decisions of human iPSC-derived bipotential hepatoblasts depend on cell density.
Graffmann N, Ncube A, Wruck W, Adjaye J.
PLoS One. 2018 Jul 10;13(7):e0200416. doi: 10.1371/journal.pone.0200416. eCollection 2018. Weblink

Lymphoblast-derived integration-free iPSC line AD-TREM2-3 from a 74 year-old Alzheimer's disease patient expressing the TREM2 p.R47H variant
Martins S, Yigit H, Bohndorf M, Graffmann N, Fiszl AR, Wruck W, Sleegers K, Van Broeckhoven C, Adjaye J
Stem Cell Research. 2018 doi: 10.1016/j.scr.2018.05.018 Weblink

Modeling Late-Onset Sporadic Alzheimer's Disease through BMI1 Deficiency.
Flamier A, El Hajjar J, Adjaye J, Fernandes KJ, Abdouh M, Bernier G.
Cell Rep. 2018 May 29;23(9):2653-2666. doi: 10.1016/j.celrep.2018.04.097. Weblink

Pluripotent stem cells: induction and self-renewal.
Abu-Dawud R, Graffmann N, Ferber S, Wruck W, Adjaye J.
Philos Trans R Soc Lond B Biol Sci. 2018 Jul 5;373(1750). pii: 20170213. doi: 10.1098/rstb.2017.0213. Review. Weblink

The presence of human mesenchymal stem cells of renal origin in amniotic fluid increases with gestational time.

Rahman MS, Spitzhorn LS, Wruck W, Hagenbeck C, Balan P, Graffmann N, Bohndorf M, Ncube A, Guillot PV, Fehm T, Adjaye J.

Stem Cell Research & Therapy (2018) 9:113 doi: 10.1186/s13287-018-0864-7 Weblink

Lymphoblast-derived integration-free iPSC line AD-TREM2-1 from a 67 year-old Alzheimer's disease patient expressing the TREM2 p.R47H variant.

Martins S, Yigit H, Bohndorf M, Graffmann N, Fiszl AR, Wruck W, Sleegers K, van Broeckhoven C, Adjaye J.
Stem Cell Research. 2018 doi: 10.1016/j.scr.2018.03.011 Weblink

Human pluripotent stem cell derived HLC transcriptome data enables molecular dissection of hepatogenesis.

Wruck W, Adjaye J.
Sci Data. 2018 Mar 13;5:180035. doi: 10.1038/sdata.2018.35. Weblink


Isolation and Molecular Characterization of Amniotic Fluid-Derived Mesenchymal Stem Cells Obtained from Caesarean Sections.

Spitzhorn LS, Rahman MS, Schwindt L, Ho HT, Wruck W, Bohndorf M, Wehrmeyer S, Ncube A, Beyer I, Hagenbeck C, Balan P, Fehm T, Adjaye J.
Stem Cells Int. 2017;2017:5932706. doi: 10.1155/2017/5932706. Epub 2017 Oct 31. Weblink

Lymphoblast-derived integration-free ISRM-CON9 iPS cell line from a 75 year old female.

Martins S, Bohndorf M, Schröter F, Assar F, Wruck W, Sleegers K, Van Broeckhoven C, Adjaye J.
Stem Cell Research. 2017 doi: 10.1016/j.scr.2017.12.007 Weblink

Comparative performance analysis of human iPSC-derived and primary neural progenitor cells (NPC) grown as neurospheres in vitro.

Hofrichter M, Nimtz L, Tigges J, Kabiri Y, Schröter F, Royer-Pokora B, Hildebrandt B, Schmuck M, Epanchintsev A, Theiss S, Adjaye J, Egly JM, Krutmann J, Fritsche E.
Stem Cell Res. 2017 Oct 26;25:72-82. doi: 10.1016/j.scr.2017.10.013. [Epub ahead of print]. Weblink

Derivation and characterization of integration-free iPSC line ISRM-UM51 derived from SIX2-positive renal cells isolated from urine of an African male expressing the CYP2D6 *4/*17 variant which confers intermediate drug metabolizing activity.

Bohndorf M, Ncube A, Spitzhorn LS, Enczmann J, Wruck W, Adjaye J.
Stem Cell Research 25:18-21, 2017. Weblink

Human mesenchymal factors induce rat hippocampal- and human neural stem cell dependent oligodendrogenesis.

Jadasz JJ, Tepe L, Beyer F, Samper Agrelo I, Akkermann R, Spitzhorn LS, Silva ME, Oreffo ROC, Hartung HP, Prigione A, Rivera FJ, Adjaye J, Küry P.
Glia. 2017 Sep 22. doi: 10.1002/glia.23233. [Epub ahead of print] Weblink

ZSCAN10 expression corrects the genomic instability of iPSCs from aged donors.

Skamagki M, Correia C, Yeung P, Baslan T, Beck S, Zhang C, Ross CA, Dang L, Liu Z, Giunta S, Chang TP, Wang J, Ananthanarayanan A, Bohndorf M, Bosbach B, Adjaye J, Funabiki H, Kim J, Lowe S, Collins JJ, Lu CW, Li H, Zhao R, Kim K.
Nat Cell Biol. 2017 Sep;19(9):1037-1048. doi: 10.1038/ncb3598. Epub 2017 Aug 28. Weblink

Nijmegen Breakage Syndrome fibroblasts and iPSCs: cellular models for uncovering disease-associated signaling pathways and establishing a screening platform for anti-oxidants.

Mlody B, Wruck W, Martins S, Sperling K, Adjaye J.
Sci Rep. 2017 Aug 8;7(1):7516. doi: 10.1038/s41598-017-07905-2. Weblink

Footprint-free human fetal foreskin derived iPSCs: A tool for modeling hepatogenesis associated gene regulatory networks.

Matz P, Wruck W, Fauler B, Herebian D, Mielke T, Adjaye J.
Sci Rep. 2017 Jul 24;7(1):6294. doi: 10.1038/s41598-017-06546-9. Weblink

New Insights into Human Primordial Germ Cells and Early Embryonic Development from Single-Cell Analysis.
Otte J, Wruck W, Adjaye J.
FEBS Lett. 2017 Jun 18. doi: 10.1002/1873-3468.12716. [Epub ahead of print] Weblink

Human iPSC-Derived Neural Progenitors Are an Effective Drug Discovery Model for Neurological mtDNA Disorders.
Lorenz C, Lesimple P, Bukowiecki R, Zink A, Inak G, Mlody B, Singh M, Semtner M, Mah N, Auré K, Leong M, Zabiegalov O, Lyras EM, Pfiffer V, Fauler B, Eichhorst J, Wiesner B, Huebner N, Priller J, Mielke T, Meierhofer D, Izsvák Z, Meier JC, Bouillaud F, Adjaye J, Schuelke M, Wanker EE, Lombès A, Prigione A.
Cell Stem Cell. 2017 May 4;20(5):659-674.e9. doi: 10.1016/j.stem.2016.12.013. Epub 2017 Jan 26. Weblink

Meta-analysis reveals up-regulation of cholesterol processes in non-alcoholic and down-regulation in alcoholic fatty liver disease.
Wruck W and Adjaye J.
World J Hepatol. 2017 Mar 18;9(8):443-454. doi: 10.4254/wjh.v9.i8.443. Weblink

Generation and characterization of two iPSC lines from human epicardium-derived cells
Paulitschek C, Schulze-Matz P, Hesse J, Schmidt T, Wruck W, Adjaye J, Schrader J.
Stem Cell Research 20:50–53 April, 2017. Weblink

Use of Stem Cells in Toxicology.
Matz P, Spitzhorn L-S, Otte J, Kawala M-A, Woestmann J, Yigit H, Wruck W and Adjaye J.
Book chapter in: Reference Module in Chemistry, Molecular Sciences and Chemical Engineering. December 2016. DOI: 10.1016/B978-0-12-409547-2.12380-7.Weblink

Human amniocytes are receptive to chemically-induced reprogramming to pluripotency.
Hawkins KE, Moschidou D, Faccenda D, Wruck W, Trujillo AM, Hau K-L, Ranzoni AM, Sanchez-Freire V, Tommasini F, Eaton S, De  Coppi P, Monk D, Campanella M, Thrasher AJ, Adjaye J, Guillot PV.
Molecular Therapy (2017), doi: 10.1016/j.ymthe.2016.11.014.  Weblinkpress release


Dissecting the complexity of cell types present in urine, identifies renal progenitor cells with regenerative potential.
Bohndorf M, Spitzhorn L-S, Wruck W, Asar F, Matz P, Ncube A, Niemietz C, Sauer V, Schmidt H-J and Adjaye J.
Poster at the 4th Annual Conference of the German Stem Cell Network (GSCN), (2016) Medical School Hannover, Germany. PDF

Characterization of iPSCs derived from dermal fibroblasts from a healthy 19 year old female.
Kawala M-A, Bohndorf M, Graffmann N, Wruck W, Zatloukal K, Adjaye J.
Stem Cell Research 17: 597–599, 2016. Weblink

Lymphoblast-derived integration-free iPSC lines from a female and male Alzheimer's disease patient expressing different copy numbers of a coding CNV in the Alzheimer risk gene CR1.
Schröter F, Sleegers K, Van Cauwenberghe C, Bohndorf M, Wruck W, Van Broeckhoven C, Adjaye J.
Stem Cell Res. 2016;17(3): 560-563. Weblink

Lymphoblast-derived integration-free iPS cell line from a female 67-year-old Alzheimer's disease patient with TREM2 (R47H) missense mutation.
Schröter F, Sleegers K, Cuyvers E, Bohndorf M, Wruck W, Van Broeckhoven C, Adjaye J.
Stem Cell Res 17: 553–555, 2016. Weblink

Characterization of dermal fibroblast-derived iPSCs from a patient with high grade steatosis.
Kawala MA, Bohndorf M, Graffmann N, Wruck W, Zatloukal K, Adjaye J.
Stem Cell Res. 2016;17(3): 568-571. Weblink

Characterization of dermal fibroblast-derived iPSCs from a patient with low grade steatosis.
Kawala M-A, Bohndorf M, Graffmann N, Wruck W, Zatloukal K, Adjaye J
Stem Cell Res 17: 547–549, 2016. Weblink

Chromosomal Instability and Molecular Defects in Induced Pluripotent Stem Cells from Nijmegen Breakage Syndrome Patients.
Halevy T, Akov S, Bohndorf M, Mlody B, Adjaye J, Benvenisty N, Goldberg M.
Cell Rep. 2016 Aug 30;16(9):2499-511. doi: 10.1016/j.celrep.2016.07.071. Epub 2016 Aug 18. Weblink, press release

Current status and future directions on research related to non-alcoholic fatty liver disease.
Wruck W, Graffmann N, Kawala MA, Adjaye J.
Stem Cells. 2016 Jul 4. doi: 10.1002/stem.2454. [Epub ahead of print] Weblink

Modelling NAFLD with human pluripotent stem cell derived immature hepatocyte like cells reveals activation of PLIN2 and confirms regulatory functions of PPAR?
Graffmann N, Ring S, Kawala MA, Wruck W, Ncube A, Trompeter HI, Adjaye J.
Stem Cells Dev. 2016 Jun 16. [Epub ahead of print] Weblink,press release, AAAS EurekAlert Science News, ge-kompakt, cover art

Combined sequencing of mRNA and DNA from human embryonic stem cells.
Mertes F, Kuhl H, Wruck W, Lehrach H, Adjaye J.
Genomics Data, Available online 26 April 2016, ISSN 2213-5960, doi: 10.1016/j.gdata.2016.04.014. Weblink

Strategies for identifying predictive biomarkers of non-alcoholic fatty liver disease.
Wruck W, Kawala M-A, Graffmann N and Adjaye J
Drug target Review 2016, 2. (17 March 2016). Weblink

MicroRNA-15b regulates mitochondrial ROS production and the senescence-associated secretory phenotype through sirtuin 4/SIRT4.
Lang A, Grether-Beck S, Singh M, Kuck F, Jakob S, Kefalas A, Altinoluk-Hambüchen S, Graffmann N, Schneider M, Lindecke A, Brenden H, Felsner I, Ezzahoini H, Marini A, Weinhold S, Vierkötter A, Tigges J, Schmidt S, Stühler K, Köhrer K, Uhrberg M, Haendeler J, Krutmann J and Piekorz RP

Aging (Albany NY). 2016 Feb 26. [Epub ahead of print] Weblink

Meta-Analysis of Transcriptome Data Related to Hippocampus Biopsies and iPSC-Derived Neuronal Cells from Alzheimer's Disease Patients Reveals an Association with FOXA1 and FOXA2 Gene Regulatory Networks.
Wruck W, Schröter F, Adjaye J.
J Alzheimers Dis. 2016 Feb 5. [Epub ahead of print] Weblink

Episomal plasmid-based generation of induced pluripotent stem cells from fetal femur-derived human mesenchymal stromal cells.
Megges M, Oreffo ROC, Adjaye J.
Stem Cell Res 16: 128–132, 2016. Weblink

Lymphoblast-derived integration-free iPS cell line from a 65-year-old Alzheimer’s disease patient expressing the TREM2 p.R47H variant.
Schröter F, Sleegers K, Cuyvers E, Bohndorf M, Wruck W, Van Broeckhoven C, Adjaye J.
Stem Cell Res 16: 113–115, 2016. Weblink

Episomal-based generation of an iPS cell line from human fetal foreskin fibroblasts.
Matz P, Adjaye J.
Stem Cell Res 16: 67–69, 2016. Weblink


Multi-omic profiles of human non-alcoholic fatty liver disease tissue highlight heterogenic phenotypes.
Wruck W, Kashofer K, Rehman S, Daskalaki A, Berg D, Gralka E, Jozefczuk J, Drews K, Pandey V, Regenbrecht C, Wierling C, Turano P, Korf U, Zatloukal K, Lehrach H, Westerhoff HV, Adjaye J.
Scientific Data 2: 150068, 2015. Weblink, press release, AAAS EurekAlert Science News

Lymphoblast-derived integration-free iPS cell line from a 69-year-old male.
Schröter F, Sleegers K, Bohndorf M, Wruck W, Van Broeckhoven C, Adjaye J.
Stem Cell Res.  doi: 10.1016/j.scr.2015.11.016. Weblink

Generation of iPSC line epiHUVEC from human umbilical vein endothelial cells.
Matz P, Adjaye J.
Stem Cell Res 15: 581–583, 2015. Weblink

Generation of iPSC lines from primary human amniotic fluid cells.
Drews K, Matz P, Adjaye J.
Stem Cell Res.  doi: 10.1016/j.scr.2015.11.003. Weblink

Generation of iPSC lines from primary human chorionic villi cells.
Lichtner B, Matz P, Adjaye J.
Stem Cell Res.  doi: 10.1016/j.scr.2015.10.011. Weblink

Generation of an iPS cell line from bone marrow derived mesenchymal stromal cells from an elderly patient.
Megges M, Geissler S, Duda GN, Adjaye J.
Stem Cell Res 15: 565–568, 2015. Weblink

Generation of iPSC lines from a Nijmegen Breakage Syndrome patient.
Mlody B, Adjaye J.
Stem Cell Res.  doi: 10.1016/j.scr.2015.10.013. Weblink

Combined ultra-low input mRNA and whole-genome sequencing of human embryonic stem cells.
Mertes F, Lichtner B, Kuhl H, Blattner M, Otte J, Wruck W, Timmermann B, Lehrach H, Adjaye J.
BMC Genomics. 2015 Nov 12;16(1):925. doi: 10.1186/s12864-015-2025-z. Weblink

3D culture of ovarian follicles: a system towards their engineering?
Zuccotti M, Merico V, Rebuzzini P, Belli M, Vigone G, Mulas F, Fassina L, Wruck W, Adjaye J, Bellazzi R, Garagna S.
Int J Dev Biol. 2015;59(4-5-6):211-216. Weblink

Association between in vivo bone formation and ex vivo migratory capacity of human bone marrow stromal cells.
Andersen RK, Zaher W, Larsen KH, Ditzel N, Drews K, Wruck W, Adjaye J, Abdallah BM, Kassem M.
Stem Cell Res Ther. 2015 Oct 8;6:196. doi: 10.1186/s13287-015-0188-9. Weblink

CD34 defines an osteoprogenitor cell population in mouse bone marrow stromal cells.
Abdallah BM, Al-Shammary A, Skagen P, Abu Dawud R, Adjaye J, Aldahmash A, Kassem M.
Stem Cell Res. 2015 Sep 21;15(3):449-458. doi: 10.1016/j.scr.2015.09.005. [Epub ahead of print] Weblink

Ethyl 2-((4-chlorophenyl)amino)thiazole-4-carboxylate and derivatives are potent inducers of Oct3/4.
Cheng X, Yoshida H, Raoofi D, Saleh S, Alborzinia H, Wenke F, Goehring A, Reuter S, Mah N, Fuchs HR, Andrade-Navarro MA, Adjaye J, Gul S, Utikal J, Mrowka R, Wölfl S.

J Med Chem. 2015 Jul 5. [Epub ahead of print] Weblink

Age-related increase of EED expression in early hematopoietic progenitor cells is associated with global increase of the histone modification H3K27me3.
Graffmann N, Brands J, Görgens A, Vitoriano da Conceição Castro S, Santourlidis S, Reckert A, Michele I, Ritz-Timme S, Fischer JC, Adjaye J, Kögler G, Giebel B, Uhrberg M.

Stem Cells Dev. 2015 May 11. [Epub ahead of print] Weblink

Identification of 2-[4-[(4-methoxyphenyl)methoxy]-phenyl]acetonitrile and derivatives as potent Oct3/4 inducers.
Cheng X, Dimou E, Alborzinia H, Wenke F, Goehring A, Reuter S, Mah N, Fuchs HR, Andrade-Navarro MA, Adjaye J, Gul S, Harms C, Utikal J, Klipp E, Mrowka R, Wölfl S.

J Med Chem. 2015 Apr 21. [Epub ahead of print] Weblink

The promise of induced pluripotent stem cells for liver disease, toxicology and drug discovery.
Graffmann N., Matz P., Wruck W. and Adjaye J.

Drug target Review 2015, 1. (9 April 2015). Weblink

Induced pluripotent stem cell-derived neuronal cells from a sporadic Alzheimer’s disease donor as a model for investigating AD-associated gene regulatory networks.
Hossini AM, Megges M, Prigione A, Lichtner B, Toliat MR, Wruck W, Schröter F,  Nuernberg P, Kroll H, Makrantonaki E, Zoubouliss CC, Adjaye J.

BMC Genomics 2015, 16:84  . Weblink

Metabolic restructuring and cell fate conversion.
Prigione A, Ruiz-Pérez MV, Bukowiecki R, Adjaye J.

Cell Mol Life Sci. 2015 Jan 14. [Epub ahead of print]. Weblink


A mitochondrial strategy for safeguarding the reprogrammed genome.
Prigione A, Adjaye J.
Cell Regen (Lond). 2014 Mar 29;3(1):5. eCollection 2014. Weblink

miR-27 Negatively Regulates Pluripotency-Associated Genes in Human Embryonal Carcinoma Cells.
Fuchs H., Theuser M., Wruck W., Adjaye J.

PLoS One. 2014 Nov 4;9(11):e111637. doi: 10.1371/journal.pone.0111637. eCollection 2014. Weblink

The proteasome complex and the maintenance of pluripotency: sustain the fate by mopping up?
Schröter F. and Adjaye J.

(2014) Stem Cell Research & Therapy 2014, 5:24 Weblink

Characterisation of human induced pluripotent stem cell-derived hepatocyte-like cells and endodermal progenitors
Matz P., Adjaye J.

(2014) European Journal of Medical Research, 19(Suppl 1):S8. doi:10.1186/2047-783X-19-S1-S8. Weblink

HIF1? modulates cell fate reprogramming through early glycolytic shift and upregulation of PDK1-3 and PKM2.
Prigione A, Rohwer N, Hoffmann S, Mlody B, Drews K, Bukowiecki R, Blümlein K, Wanker EE, Ralser M, Cramer T, Adjaye J.

Stem Cells. 2014 Feb;32(2):364-76. doi: 10.1002/stem.1552. PMID 24123565 PubMed

Mitochondrial Function in Pluripotent Stem Cells and Cellular Reprogramming.
Bukowiecki R, Adjaye J, Prigione A.

Gerontology. 2014;60(2):174-82. doi: 10.1159/000355050. Epub 2013 Nov 19. PMID:24281332 PubMed

Data management strategies for multinational large-scale systems biology projects.
Wruck W, Peuker M, Regenbrecht CR.

Brief Bioinform. 2014 Jan;15(1):65-78. doi: 10.1093/bib/bbs064. Epub 2012 Oct 9. PubMed


Qualitative modeling identifies IL-11 as a novel regulator in maintaining self-renewal in human pluripotent stem cells.
Peterson H, Abu Dawud R, Garg A, Wang Y, Vilo J, Xenarios I, Adjaye J.

Front Physiol. 2013 Oct 28;4:303. doi: 10.3389/fphys.2013.00303. PMID: 24194720 PubMed

HIF1? modulates reprogramming through early glycolytic shift and up-regulation of PDK1-3 and PKM2.
Prigione A, Rohwer N, Hoffman S, Mlody B, Drews K, Bukowiecki R, Blümlein K, Wanker EE, Ralser M, Cramer T, Adjaye J.

Stem Cells. 2013 Oct 1. doi: 10.1002/stem.1552. [Epub ahead of print] PMID: 24123565 PubMed

BMP10 as a potent inducer of trophoblast differentiation in human embryonic and induced pluripotent stem cells.
Lichtner B, Knaus P, Lehrach H, Adjaye J.

Biomaterials. 2013 Sep 23. doi:pii: S0142-9612(13)01062-4. 10.1016/j.biomaterials.2013.08.084. [Epub ahead of print]

PMID: 24070570 PubMed

Mesenchymal stem cell conditioning promotes rat oligodendroglial cell maturation.
Jadasz JJ, Kremer D, Göttle P, Tzekova N, Domke J, Rivera FJ, Adjaye J, Hartung HP, Aigner L, Küry P.

PLoS One. 2013 Aug 12;8(8):e71814. doi: 10.1371/journal.pone.0071814. eCollection 2013.

PMID: 23951248 PubMed

Mouse embryonic stem cells irradiated with ?-rays differentiate into cardiomyocytes but with altered contractile properties.
Rebuzzini P, Fassina L, Mulas F, Bellazzi R, Redi CA, Di Liberto R, Magenes G, Adjaye J, Zuccotti M, Garagna S.

 Mutat Res. 2013 Jun 20. doi:pii: S1383-5718(13)00157-5. 10.1016/j.mrgentox.2013.06.007. [Epub ahead of print] PMID: 23792212 PubMed

Transcriptome based identification of mouse cumulus cell markers that predict the developmental competence of their enclosed antral oocytes.
Vigone G, Merico V, Prigione A, Mulas F, Sacchi L, Gabetta M, Bellazzi R, Redi CA, Mazzini G, Adjaye J, Garagna S, Zuccotti M.

 BMC Genomics. 2013 Jun 7;14:380. doi: 10.1186/1471-2164-14-38 PMID: 23758669 PubMed

Current methods for inducing pluripotency in somatic cells.
Tavernier G, Mlody B, Demeester J, Adjaye J, De Smedt SC.

 Adv Mater. 2013 May 28;25(20):2765-71. doi: 10.1002/adma.201204874. Epub 2013 Mar 26. PMID: 23529911 PubMed


OCT4 and the acquisition of oocyte developmental competence during folliculogenesis.
Zuccotti M, Merico V, Belli M, Mulas F, Sacchi L, Zupan B, Redi CA, Prigione A,  Adjaye J, Bellazzi R, Garagna S.

Int J Dev Biol. 2012;56(10-11-12):853-858.  PMID: 23417407  PubMed

Comparative molecular portraits of human unfertilized oocytes and primordial germ cells at 10 weeks of gestation.
Diedrichs F, Mlody B, Matz P, Fuchs H, Chavez L, Drews K, Adjaye J.

Int J Dev Biol. 2012;56(10-11-12):789-797. PMID: 23417401 PubMed

Functional comparison of chronological and in vitro aging: differential role of the cytoskeleton and mitochondria in mesenchymal stromal cells.
Geißler S, Textor M, Kühnisch J, Könnig D, Klein O, Ode A, Pfitzner T, Adjaye J, Kasper G, Duda GN.

PLoS One. 2012;7(12):e52700. doi: 10.1371/journal.pone.0052700. Epub 2012 Dec 28.

PMID: 23285157 PubMed

Molecular signature of human amniotic fluid stem cells during fetal development.
Moschidou D, Drews K, Eddaoudi A, Adjaye J, De Coppi P, Guillot PV.

Curr Stem Cell Res Ther. 2012 Dec 24. [Epub ahead of print]  PMID: 23270629 PubMed

Identification of biomarkers of human skin ageing in both genders. Wnt signalling - a label of skin ageing?
Makrantonaki E, Brink TC, Zampeli V, Elewa RM, Mlody B, Hossini AM, Hermes B, Krause U, Knolle J, Abdallah M, Adjaye J, Zouboulis CC.

PLoS One. 2012;7(11):e50393. doi: 10.1371/journal.pone.0050393. Epub 2012 Nov 30. PMID: 23226273  PubMed

A Systems Biology Approach to Deciphering the Etiology of Steatosis Employing Patient-Derived Dermal Fibroblasts and iPS Cells.
Jozefczuk J, Kashofer K, Ummanni R, Henjes F, Rehman S, Geenen S, Wruck W, Regenbrecht C, Daskalaki A, Wierling C, Turano P, Bertini I, Korf U, Zatloukal K, Westerhoff HV, Lehrach H, Adjaye J.

Front Physiol. 2012;3:339. Epub 2012 Sep 3.  PMID: 22969728 PubMed

Human embryonic stem cells and embryonal carcinoma cells have overlapping and distinct metabolic signatures.
Abu Dawud R, Schreiber K, Schomburg D, Adjaye J.

PLoS One. 2012;7(6):e39896.  PMID: 22768158 PubMed

Valproic Acid Confers Functional Pluripotency to Human Amniotic Fluid Stem Cells in a Transgene-free Approach.
Moschidou D, Mukherjee S, Blundell MP, Drews K, Jones GN, Abdulrazzak H, Nowakowska B, Phoolchund A, Lay K, Ramasamy TS, Cananzi M, Nettersheim D, Sullivan M, Frost J, Moore G, Vermeesch JR, Fisk NM, Thrasher AJ, Atala A, Adjaye J, Schorle H, De Coppi P, Guillot PV.

Mol Ther. 2012 Jul 3. doi: 10.1038/mt.2012.117.  PMID: 22760542 PubMed

FGF inhibition directs BMP4-mediated differentiation of Human Embryonic Stem Cells to syncytiotrophoblast.
Sudheer S, Bhushan R, Fauler B, Lehrach H, Adjaye J.

Stem Cells Dev. 2012 Jun 22.  PMID: 22724507 PubMed

Preparation of Mouse Embryonic Fibroblast Cells Suitable for Culturing Human Embryonic and Induced Pluripotent Stem Cells.
Jozefczuk, J., Drews, K., Adjaye, J.

J. Vis. Exp. (64), e3854, DOI: 10.3791/3854 (2012)  PMID: 22760161 PubMed

Human induced pluripotent stem cells-from mechanisms to clinical applications.
Drews K, Jozefczuk J, Prigione A, Adjaye J.

J Mol Med (Berl). 2012 May 30. PMID: 22643868 PubMed

Human Stromal (Mesenchymal) Stem Cells from Bone Marrow, Adipose Tissue and Skin Exhibit Differences in Molecular Phenotype and Differentiation Potential.
Al-Nbaheen M, Vishnubalaji R, Ali D, Bouslimi A, Al-Jassir F, Megges M, Prigione A, Adjaye J, Kassem M, Aldahmash A.

Stem Cell Rev. 2012 Apr 14.  PMID: 22529014 PubMed

Analysis of the methylome of human embryonic stem cells employing methylated DNA immunoprecipitation coupled to next-generation sequencing.
Grimm C, Adjaye J.

Methods Mol Biol. 2012;873:281-95.  PMID: 22528363 PubMed

Chromatin immunoprecipitation-based analysis of gene regulatory networks operative in human embryonic stem cells.
Jung M, Adjaye J.

Methods Mol Biol. 2012;873:269-80.  PMID: 22528362 PubMed

Teratoma formation of human embryonic stem cells in three-dimensional perfusion culture bioreactors.
J Tissue Eng Regen Med. 2012 Mar 21. PMID:&nb

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Combinatorial binding in human and mouse embryonic stem cells identifies conserved enhancers active in early embryonic development.
Göke J, Jung M, Behrens S, Chavez L, O'Keeffe S, Timmermann B, Lehrach H, Adjaye J, Vingron M.

PLoS Comput Biol. 2011 Dec;7(12): Epub 2011 Dec 22.  PMID: 22215994 PubMed

Mitochondrial-Associated Cell Death Mechanisms Are Reset to an Embryonic-Like State in Aged Donor-Derived iPS Cells Harboring Chromosomal Aberrations.
PLoS One. 2011;6(11):e27352. Epub 2011 Nov 14.  PMID: 22110631 PubMed

Quantitative Real-Time PCR-Based Analysis of Gene Expression.
Methods Enzymol. 2011;500:99-109.  PMID: 21943894 PubMed

A strand-specific library preparation protocol for RNA sequencing.
Borodina T, Adjaye J, Sultan M.

Methods Enzymol. 2011;500:79-98.  PMID: 21943893 PubMed

Molecular Insights into Reprogramming-Initiation Events Mediated by the OSKM Gene Regulatory Network.
Mah N, Wang Y, Liao MC, Prigione A, Jozefczuk J, Lichtner B, Wolfrum K, Haltmeier M, Flöttmann M, Schaefer M, Hahn A, Mrowka R, Klipp E, Andrade-Navarro MA, Adjaye J.

PLoS One. 2011;6(8):e24351. Epub 2011 Aug 31.  PMID: 21909390 PubMed

Human iPSCs Harbor Homoplasmic and Heteroplasmic Mitochondrial DNA Mutations While Maintaining hESC-Like Metabolic Reprogramming.
Prigione A, Lichtner B, Kuhl H, Struys EA, Wamelink M, Lehrach H, Ralser M, Timmermann B, Adjaye J.

Stem Cells. 2011 Jul 5. doi: 10.1002/stem.683.  PMID: 21732474 PubMed

Gatekeeper of pluripotency: A common Oct4 transcriptional network operates in mouse eggs and embryonic stem cells.
Zuccotti M, Merico V, Bellone M, Mulas F, Sacchi L, Rebuzzini P, Prigione A, Redi CA, Bellazzi R, Adjaye J, Garagna S.

BMC Genomics. 2011 Jul 5;12(1):345.  PMID: 21729306 PubMed

Network-Like Impact of MicroRNAs on Neuronal Lineage Differentiation of Unrestricted Somatic Stem Cells from Human Cord Blood.
Iwaniuk KM, Schira J, Weinhold S, Jung M, Adjaye J, Müller HW, Wernet P, Trompeter HI.

Stem Cells Dev. 2011 Mar 8.  PMID: 21067317 PubMed

Comparative Analysis of Human Embryonic Stem Cell and Induced Pluripotent Stem Cell-Derived Hepatocyte-Like Cells Reveals Current Drawbacks and Possible Strategies for Improved Differentiation.
Jozefczuk J, Prigione A, Chavez L, Adjaye J.

Stem Cells Dev. 2011 Jan 24.  PMID: 21162674 PubMed


An ES-like pluripotent state in FGF-dependent murine iPS cells.
Di Stefano B, Buecker C, Ungaro F, Prigione A, Chen HH, Welling M, Eijpe M, Mostoslavsky G, Tesar P, Adjaye J, Geijsen N, Broccoli V.

PLoS One. 2010 Dec 30;5(12):e16092.  PMID: 21209851 PubMed

Bioinformatics in aging research: a workshop report.
Fuellen G, Adjaye J, de Grey A, Lepperdinger G, de Magalhães JP, Sühnel J, Wipat A.

Rejuvenation Res. 2010 Dec;13(6):763-7. Epub 2011 Jan 4.  PMID: 21204651 PubMed

A Cyclic AMP Analog, 8-Br-cAMP, Enhances the Induction of Pluripotency in Human Fibroblast Cells.
Wang Y, Adjaye J.

Stem Cell Rev. 2010 Dec 1. [Epub ahead of print]  PMID: 21120637 PubMed

The LARGE principle of cellular reprogramming: lost, acquired and retained gene expression in foreskin and amniotic fluid-derived human iPS cells.
Wolfrum K, Wang Y, Prigione A, Sperling K, Lehrach H, Adjaye J.

PLoS One. 2010 Oct 29;5(10):e13703.  PMID: 21060825  PubMed

Skin and brain age together: The role of hormones in the ageing process.
Makrantonaki E, Schönknecht P, Hossini AM, Kaiser E, Katsouli MM, Adjaye J, Schröder J, Zouboulis CC.

Exp Gerontol. 2010 Oct;45(10):801-13. Epub 2010 Aug 16. Review.  PMID: 20719245 PubMed

Computational analysis of genome-wide DNA methylation during the differentiation of human embryonic stem cells along the endodermal lineage.
Chavez L, Jozefczuk J, Grimm C, Dietrich J, Timmermann B, Lehrach H, Herwig R, Adjaye J.

Genome Res. 2010 Oct;20(10):1441-50. Epub 2010 Aug 27.  PMID: 20802089 PubMed

Molecular characterization of cultured adult human liver progenitor cells.
Jozefczuk J, Stachelscheid H, Chavez L, Herwig R, Lehrach H, Zeilinger K, Gerlach JC, Adjaye J.

Tissue Eng Part C Methods. 2010 Oct;16(5):821-34.  PMID: 19874131 PubMed

Governing cell lineage formation in cloned mouse embryos.
Balbach ST, Esteves TC, Brink T, Gentile L, McLaughlin KJ, Adjaye JA, Boiani M.

Dev Biol. 2010 Jul 1;343(1-2):71-83. Epub 2010 Apr 22.  PMID: 20417198  PubMed

A transcriptional roadmap to the induction of pluripotency in somatic cells.
Wang Y, Mah N, Prigione A, Wolfrum K, Andrade-Navarro MA, Adjaye J.

Stem Cell Rev. 2010 Jun;6(2):282-96. Review.  PMID: 20336394 PubMed

A data integration approach to mapping OCT4 gene regulatory networks operative in embryonic stem cells and embryonal carcinoma cells.
Jung M, Peterson H, Chavez L, Kahlem P, Lehrach H, Vilo J, Adjaye J.

PLoS One. 2010 May 21;5(5):e10709.  PMID: 20505756 PubMed

Cancer stem cells in solid tumors: elusive or illusive?
Welte Y, Adjaye J, Lehrach HR, Regenbrecht CR.

Cell Commun Signal. 2010 May 11;8(1):6.  PMID: 20459772 PubMed

The senescence-related mitochondrial/oxidative stress pathway is repressed in human induced pluripotent stem cells.
Prigione A, Fauler B, Lurz R, Lehrach H, Adjaye J.

Stem Cells. 2010 Apr;28(4):721-33.  PMID: 20201066 PubMed

Modulation of mitochondrial biogenesis and bioenergetic metabolism upon in vitro and in vivo differentiation of human ES and iPS cells.
Prigione A, Adjaye J.

Int J Dev Biol. 2010;54(11-12):1729-41.  PMID: 21305470  PubMed


Comparative proteome and transcriptome analyses of embryonic stem cells during embryoid body-based differentiation.
Fathi A, Pakzad M, Taei A, Brink TC, Pirhaji L, Ruiz G, Sharif Tabe Bordbar M, Gourabi H, Adjaye J, Baharvand H, Salekdeh GH.

Proteomics. 2009 Nov;9(21):4859-70.  PMID: 19862760 PubMed

Age-related transcriptional changes in gene expression in different organs of mice support the metabolic stability theory of aging.
Brink TC, Demetrius L, Lehrach H, Adjaye J.

Biogerontology. 2009 Oct;10(5):549-64. Epub 2008 Nov 23.  PMID: 19031007 PubMed

Oct-4 regulates the expression of Stella and Foxj2 at the Nanog locus: implications for the developmental competence of mouse oocytes.
Zuccotti M, Merico V, Sacchi L, Bellone M, Brink TC, Stefanelli M, Redi CA, Bellazzi R, Adjaye J, Garagna S.

Hum Reprod. 2009 Sep;24(9):2225-37. Epub 2009 May 28.  PMID: 19477878 PubMed

In silico identification of a core regulatory network of OCT4 in human embryonic stem cells using an integrated approach.
Chavez L, Bais AS, Vingron M, Lehrach H, Adjaye J, Herwig R.

BMC Genomics. 2009 Jul 15;10:314.  PMID: 19604364 PubMed

Activation of the immune response is a key feature of aging in mice.
Brink TC, Regenbrecht C, Demetrius L, Lehrach H, Adjaye J.

Biogerontology. 2009 Mar 3.  PMID: 19255868 PubMed

Role of Oct-4 during acquisition of developmental competence in mouse oocyte.
Zuccotti M, Merico V, Redi CA, Bellazzi R, Adjaye J, Garagna S.

Reprod Biomed Online. 2009;19 Suppl 3:57-62. Review.  PMID: 20034424 PubMed

Genome-wide expression profiling reveals distinct clusters of transcriptional regulation during bovine preimplantation development in vivo.
Kues WA, Sudheer S, Herrmann D, Carnwath JW, Havlicek V, Besenfelder U, Lehrach H, Adjaye J, Niemann H.

Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19768-73. Erratum in: Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1679.


Pluripotency and differentiation in embryos and stem cells.
Adjaye JA, Byskov AG, Cibelli JB, De Maria R, Minger S, Sampaolesi M, Testa G, Verfaillie C, Zernicka-Goetz M, Schöler H, Boiani M, Crosetto N, Redi CA.

Int J Dev Biol. 2008;52(7):801-9.  PMID: 18956312 PubMed

The molecular basis of genistein-induced mitotic arrest and exit of self-renewal in embryonal carcinoma and primary cancer cell lines.
Regenbrecht CR, Jung M, Lehrach H, Adjaye J.

BMC Med Genomics. 2008 Oct 10;1:49.  PMID: 18847459 PubMed

Maternal Oct-4 is a potential key regulator of the developmental competence of mouse oocytes.
Zuccotti M, Merico V, Sacchi L, Bellone M, Brink TC, Bellazzi R, Stefanelli M, Redi CA, Garagna S, Adjaye J.

BMC Dev Biol. 2008 Oct 6;8:97.  PMID: 18837968 PubMed

Human skin stem cells and the ageing process.
Zouboulis CC, Adjaye J, Akamatsu H, Moe-Behrens G, Niemann C.

Exp Gerontol. 2008 Nov;43(11):986-97. PMID: 18809487 PubMed

Stemming cancer: functional genomics of cancer stem cells in solid tumors.
Regenbrecht CR, Lehrach H, Adjaye J.

Stem Cell Rev. 2008 Dec;4(4):319-28. Review.  PMID: 18561035 PubMed

Control of early fate decisions in human ES cells by distinct states of TGFbeta pathway activity.
Greber B, Lehrach H, Adjaye J.

Stem Cells Dev. 2008 Dec;17(6):1065-77.  PMID: 18393632 PubMed

The origins of human embryonic stem cells: a biological conundrum.
Brink TC, Sudheer S, Janke D, Jagodzinska J, Jung M, Adjaye J.

Cells Tissues Organs. 2008;188(1-2) Dec 20.  PMID: 18160822 PubMed


Generation of amplified RNAs and cDNA libraries from single mammalian cells.
Adjaye J.

Methods Mol Med. 2007;132:117-24.  PMID: 17876080 PubMed

Functional genomics of human pre-implantation development.
Sudheer S, Adjaye J.

Brief Funct Genomic Proteomic. 2007 Jun;6(2):120-32. Review.   PMID: 17670767 PubMed

Conserved molecular portraits of bovine and human blastocysts as a consequence of the transition from maternal to embryonic control of gene expression.
Adjaye J, Herwig R, Brink TC, Herrmann D, Greber B, Sudheer S, Groth D, Carnwath JW, Lehrach H, Niemann H.

Physiol Genomics. 2007 Oct 22;31(2):315-27. Epub 2007 Jun 26.  PMID: 17595343 PubMed

Silencing of core transcription factors in human EC cells highlights the importance of autocrine FGF signaling for self-renewal.
Greber B, Lehrach H, Adjaye J.

BMC Dev Biol. 2007 May 16;7:46.  PMID: 17506876 PubMed

Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells.
Babaie Y, Herwig R, Greber B, Brink TC, Wruck W, Groth D, Lehrach H, Burdon T, Adjaye J.

Stem Cells. 2007 Feb;25(2):500-10. Epub 2006 Oct 26.  PMID: 17068183 PubMed

Fibroblast growth factor 2 modulates transforming growth factor beta signaling in mouse embryonic fibroblasts and human ESCs (hESCs) to support hESC self-renewal.
Greber B, Lehrach H, Adjaye J.

Stem Cells. 2007 Feb;25(2):455-64.  PMID: 17038665 PubMed


Aging of human sebocytes in vitro induced by exposure to a defined hormone environment.
Makrantonaki E, Adjaye J, Herwig R, Brink TC, Groth D, Hultschig C, Lehrach H, Zouboulis CC.

Dermatology. 2006;213(3):262-3. No abstract available.  PMID: 17033188 PubMed

Age-specific hormonal decline is accompanied by transcriptional changes in human sebocytes in vitro.
Makrantonaki E, Adjaye J, Herwig R, Brink TC, Groth D, Hultschig C, Lehrach H, Zouboulis CC.

Aging Cell. 2006 Aug;5(4):331-44. Epub 2006 Jun 29.  PMID: 16805856 PubMed


Matrix metalloproteinases of epithelial origin in facial sebum of patients with acne and their regulation by isotretinoin.
Papakonstantinou E, Aletras AJ, Glass E, Tsogas P, Dionyssopoulos A, Adjaye J, Fimmel S, Gouvousis P, Herwig R, Lehrach H, Zouboulis CC, Karakiulakis G.

J Invest Dermatol. 2005 Oct;125(4):673-84.  PMID: 16185265 PubMed

Primary differentiation in the human blastocyst: comparative molecular portraits of inner cell mass and trophectoderm cells.
Adjaye J, Huntriss J, Herwig R, BenKahla A, Brink TC, Wierling C, Hultschig C, Groth D, Yaspo ML, Picton HM, Gosden RG, Lehrach H.

Stem Cells. 2005 Nov-Dec;23(10):1514-25. Epub 2005 Aug 4.  PMID: 16081659 PubMed

Whole-genome approaches for large-scale gene identification and expression analysis in mammalian preimplantation embryos.
Adjaye J.

Reprod Fertil Dev. 2005;17(1-2):37-45. Review.  PMID: 15745630 PubMed


Cross-species hybridisation of human and bovine orthologous genes on high density cDNA microarrays.
Adjaye J, Herwig R, Herrmann D, Wruck W, Benkahla A, Brink TC, Nowak M, Carnwath JW, Hultschig C, Niemann H, Lehrach H.

BMC Genomics. 2004 Oct 28;5(1):83.   PMID: 15511299 PubMed


A source for expression profiling in single preimplantation bovine embryos.
Ponsuksili S, Wimmers K, Adjaye J, Schellander K.

Theriogenology. 2002 Apr 1;57(6):1611-24.  PMID: 12035973 PubMed

Molecular approaches to the study of gene expression during human preimplantation development.
Hurley J, Huntriss J, Adjaye J.

Hum Fertil (Camb). 2000;3(1):48-51.  PMID: 11844354 PubMed

Cloning of HOXD1 from unfertilised human oocytes and expression analyses during murine oogenesis and embryogenesis.
Pitera JE, Milla PJ, Scambler P, Adjaye J.

Mech Dev. 2001 Dec;109(2):377-81.  PMID: 11731253 PubMed

Expression of homeobox-containing genes in cDNA libraries derived from cattle oocytes and preimplantation stage embryo.
Ponsuksili S, Wimmers K, Adjaye J, Schellander K.

Mol Reprod Dev. 2001 Nov;60(3):297-301.  PMID: 11599040 PubMed

Transcription of homeobox-containing genes detected in cDNA libraries derived from human unfertilized oocytes and preimplantation embryos.
Adjaye J, Monk M.

Mol Hum Reprod. 2000 Aug;6(8):707-11.  PMID: 10908280 PubMed

Expression of arylamine N-acetyltransferases in pre-term placentas and in human pre-implantation embryos.
Smelt VA, Upton A, Adjaye J, Payton MA, Boukouvala S, Johnson N, Mardon HJ, Sim E.

Hum Mol Genet. 2000 Apr 12;9(7):1101-7.  PMID: 10767335 PubMed

Developmental expression of specific genes detected in high-quality cDNA libraries from single human preimplantation embryos.
Adjaye J, Bolton V, Monk M.

Gene. 1999 Sep 17;237(2):373-83.  PMID: 10521661 PubMed

Identification of genes expressed in human primordial germ cells at the time of entry of the female germ line into meiosis.
Goto T, Adjaye J, Rodeck CH, Monk M.

Mol Hum Reprod. 1999 Sep;5(9):851-60.  PMID: 10460224 PubMed

Detection of a novel splice variant of the hypoxanthine-guanine phosphoribosyl transferase gene in human oocytes and preimplantation embryos: implications for a RT-PCR-based preimplantation diagnosis of Lesch-Nyhan syndrome.
Daniels R, Adjaye J, Bolton V, Monk M.

Mol Hum Reprod. 1998 Aug;4(8):785-9.  PMID: 9733436 PubMed

The construction of cDNA libraries from human single preimplantation embryos and their use in the study of gene expression during development.
Adjaye J, Daniels R, Monk M.

J Assist Reprod Genet. 1998 May;15(5):344-8.  PMID: 9604772 PubMed

cDNA libraries from single human preimplantation embryos.
Adjaye J, Daniels R, Bolton V, Monk M.

Genomics. 1997 Dec 15;46(3):337-44.  PMID: 9441736 PubMed

Characterisation of neurofilament protein NF70 mRNA from the gastropod Helix aspersa reveals that neuronal and non-neuronal intermediate filament proteins of cerebral ganglia arise from separate lamin-related genes.
Adjaye J, Plessmann U, Weber K, Dodemont H.

J Cell Sci. 1995 Nov;108 ( Pt 11):3581-90.  PMID: 8586669 PubMed

Immunological properties and cDNA sequence analysis of an intermediate-filament-like protein from squid neuronal tissue.
Adjaye J, Marsh PJ, Eagles PA.

J Cell Sci. 1993 Dec;106 ( Pt 4):1283-90.  PMID: 8126107 PubMed

The cytotoxic and immunogenic hurdles associated with non-viral mRNA-mediated reprogramming of human fibroblasts.
Biomaterials. 2012 Feb 28. [Epub ahead of print]  PMID: 22381475 PubMed

Activation of pluripotency-associated genes in mouse embryonic fibroblasts by non-viral transfection with in vitro-derived mRNAs encoding Oct4, Sox2, Klf4 and cMyc.
Tavernier G, Wolfrum K, Demeester J, De Smedt SC, Adjaye J, Rejman J.

Biomaterials. 2012 Jan;33(2):412-7. Epub 2011 Oct 10.  PMID: 21993235 PubMed

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