• Brinkmann, V., Ale-Agha, N., Haendeler, J.*, and Ventura, N.* (2020). The Aryl Hydrocarbon Receptor (AhR) in the Aging Process: Another Puzzling Role for This Highly Conserved Transcription Factor. Front Physiol 10, 1561. IF: 3.367
  • Ottolini, M., Hong, K., Cope, E.L., Daneva, Z., DeLalio, L.J., Sokolowski, J.D., Marziano, C., Nguyen, N.Y., Altschmied, J., Haendeler, J., Johnstone, S.R., Kalani, M.Y., Park, M.S., Patel, R.P., Liedtke, W., Isakson, B.E., and Sonkusare, S.K. (2020). Local Peroxynitrite Impairs Endothelial TRPV4 Channels and Elevates Blood Pressure in Obesity. Circulation 141, 1318-1333. IF: 23.603
  • Rosen, J., Jakobs, P., Ale-Agha, N., Altschmied, J., Haendeler, J. (2020) Non-canonical functions of telomerase reverse transcriptase - impact on redox homeostasis. Redox Biol. 34, 101543. IF: 9.986
  • Spannbrucker, T.*, Ale-Agha, N.*, Goy, C., Dyballa-Rukes, N., Jakobs, P., Jander, K., Altschmied, J., Unfried, K., and Haendeler, J. (2019) Induction of a senescent like phenotype and loss of gap junctional intercellular communication by carbon nanoparticle exposure of lung epithelial cells. Exp Gerontol 117, 106-112. IF: 3.376
  • Gonnissen, S.*, Ptok, J.*, Goy, C., Jander, K., Jakobs, P., Eckermann, O., Kaisers, W., von Ameln, F., Timm, J., Ale-Agha, N., Haendeler, J.**, Schaal, H.**, and Altschmied, J.** (2019). High Concentration of Low-Density Lipoprotein Results in Disturbances in Mitochondrial Transcription and Functionality in Endothelial Cells. Oxid Med Cell Longev 2019, 7976382. IF: 5.076
  • Grandoch, M., Flogel, U., Virtue, S., Maier, J.K., Jelenik, T., Kohlmorgen, C., Feldmann, K., Ostendorf, Y., Castaneda, T.R., Zhou, Z., Yamaguchi, Y., Nascimento, E.B.M., Sunkari, V.G., Goy, C., Kinzig, M., Sorgel, F., Bollyky, P.L., Schrauwen, P., Al-Hasani, H., Roden, M., Keipert, S., Vidal-Puig, A., Jastroch, M., Haendeler, J., and Fischer, J.W. (2019). 4-Methylumbelliferone improves the thermogenic capacity of brown adipose tissue. Nat Metab 1, 546-559. IF: approx 20
  • Heiss, C., Spyridopoulos, I., and Haendeler, J. (2018). Interventions to slow cardiovascular aging: Dietary restriction, drugs and novel molecules. Exp Gerontol 109, 108-118. IF: 3.224
  • Hendgen-Cotta, U.B., Esfeld, S., Jastrow, H., Totzeck, M., Altschmied, J., Goy, C., Haendeler, J., Winterhager, E., and Rassaf, T. (2018). Mouse cardiac mitochondria do not separate in subsarcolemmal and interfibrillar subpopulations. Mitochondrion 38, 1-5. IF: 3.226
  • Nguyen, T.D., Schwarzer, M., Schrepper, A., Amorim, P.A., Blum, D., Hain, C., Faerber, G., Haendeler, J., Altschmied, J., and Doenst, T. (2018). Increased Protein Tyrosine Phosphatase 1B (PTP1B) Activity and Cardiac Insulin Resistance Precede Mitochondrial and Contractile Dysfunction in Pressure-Overloaded Hearts. J Am Heart Assoc 7. IF: 5.117
  • Stockmann, D., Spannbrucker, T., Ale-Agha, N., Jakobs, P., Goy, C., Dyballa-Rukes, N., Hornstein, T., Kumper, A., Kraegeloh, A., Haendeler, J., and Unfried, K. (2018). Non-Canonical Activation of the Epidermal Growth Factor Receptor by Carbon Nanoparticles. Nanomaterials (Basel) 8. IF: 3.504
  • Ale-Agha, N., Goy, C., Jakobs, P., Spyridopoulos, I., Gonnissen, S., Dyballa-Rukes, N., Aufenvenne, K., von Ameln, F., Zurek, M., Spannbrucker, T., Eckermann, O., Jakob, S., Gorressen, S., Abrams, M., Grandoch, M., Fischer, J.W., Kohrer, K., Deenen, R., Unfried, K., Altschmied, J., and Haendeler, J. (2018). CDKN1B/p27 is localized in mitochondria and improves respiration-dependent processes in the cardiovascular system-New mode of action for caffeine. PLoS Biol 16, e2004408. IF: 9.163
  • Gödecke, A. and Haendeler, J. (2017) Intra- and interorgan communication in the cardiovascular system - a special view on redox regulation. Antioxid Redox Signal. 26, 613-615. IF: 7.09
  • Dyballa-Rukes, N.*, Jakobs, P.*, Eckers, A.*, Ale-Agha, N., Serbulea, V., Aufenvenne, K., Zschauer, T.C., Rabanter, L.L., Jakob, S., von Ameln, F., Eckermann, O., Leitinger, N., Goy, C., Altschmied, J., Haendeler, J. (2017) The anti-apoptotic properties of APEX1 in the endothelium require the first twenty amino acids and converge on Thioredoxin-1. Antioxid Redox Signal. 26, 616-629. IF: 7.09
  • Jakobs, P.*, Serbulea, V.*, Leitinger, N., Eckers, A., Haendeler, J. (2017) Nuclear factor (erythroid-derived 2)-like 2 and Thioredoxin-1 in atherosclerosis and ischemia/reperfusion injury in the heart. Antioxid Redox Signal. 26, 630-644. IF: 7.09
  • Kohlgrüber, S., Upadhye, A., Dyballa-Rukes, N., McNamara, C.A., Altschmied, J. (2017) Regulation of Transcription Factors by Reactive Oxygen Species and Nitric Oxide in Vascular Physiology and Pathology. Antioxid Redox Signal. 26, 679-699. IF: 7.09
  • Eckers, S*, Jakob, S., Heiss, C., Haarmann-Stemmann, T., Goy, C., Brinkmann, V., Cortese-Krott, M.M., Sansone, R., Esser, C., Ale-Agha, N., Altschmied, J., Ventura, N., Haendeler, J. (2016) The aryl hydrocarbon receptor promotes aging phenotypes across species. Sci Rep 6, 19618. IF: 5.548
  • Lang, A.*, Grether-Beck, S.*, Singh, M.*, Kuck, F., Jakob, S., Kefalas. A., Altinoluk-Hambüchen, S., Graffmann, N., Schneider, M., Lindecke, A., Brenden, H., Felsner, I., Ezzahoini,, H., Marini, A., Weinhold, S., Vierkötter, A., Tigges, J., Schmidt, S., Kai Stühler, K., Karl Köhrer, K., Uhrberg, M., Haendeler, J., Krutmann, J.#, Piekorz, R.P.# (2016) MicroRNA-15b regulates mitochondrial ROS production and the senescence-associated secretory phenotype through sirtuin 4/SIRT4. Aging (Albany, NY) 8, 484-509. IF: 3.98
  • Zurek M*, Altschmied J*, Kohlgrüber S, Ale-Agha N, Haendeler J (2016) Role of Telomerase in the cardiovascular system. Genes 7, 29-40. IF: 3.55
  • Frauenstein, K., Tigges, .J., Soshilov, A., Kado, S., Nadeshda, R., Fritsche, E., Haendeler, J., Denison, M.S., Vogel, C.F., Haarmann-Stemmann, T. (2015) Activation of the aryl hydrocarbon receptor by the widely used Src family kinase inhibitor 4-amino-5-(4-chlorophenyl)-7-(dimethylethyl)pyrazolo[3,4-d]pyrimidine (PP2). Arch Toxicol. 89, 1329-1336. IF: 5.078
  • Farrokh, S.*, Brillen, A.-L.*, Haendeler, J., Altschmied, J.#, Schaal, H.# (2015) Critical regulators of endothelial cell functions: for a change being alternative. Antioxid Redox Signal. 22, 1212-1229. (*,# contributed equally) IF: 7.407
  • Eckers, A., Haendeler, J. (2015) Endothelial cells in health and disease. Antioxid Redox Signal. 22, 1209-1211. IF: 7.407
  • Czypiorski, P.#, Altschmied, J.#, Rabanter, L.L., Goy, C., Jakob, S., Haendeler, J.* (2014) Outfielders playing in the infield: functions of “nuclear” proteins in the mitochondria. Curr. Mol. Med. 10, 1247-1251 (# contributed equally). IF: 4.197
  • Goy, C.#, Czypiorski, P.#, Altschmied, J.#, Jakob, S., Rabanter, L.L., Brewer, A.C., Ale-Agha, N., Dyballa-Rukes, N., Shah, A.M., Haendeler, J. (2014) The imbalanced redox status in senescent endothelial cells is due to dysregulated Thioredoxin-1 and NADPH oxidase 4. Exp Gerontol. 56, 45-52 (# contributed equally). IF: 3.911
  • Ale-Agha, N.#, Dyballa-Rukes, N.#, Jakob, S., Altschmied, J., Haendeler, J. (2014) Cellular functions of the dual-targeted catalytic subunit of telomerase, telomerase reverse transcriptase - Potential role in senescence and aging. Exp Gerontol. 56, 189-193 (# contributed equally). IF: 3.911
  • Tigges, J., Krutmann, J., Fritsche, E., Haendeler, J., Schaal, H., Fischer, J.W., Kalfalah, F., Reinke, H., Reifenberger, G., Stühler, K., Ventura, N., Gundermann, S., Boukamp, P., Boege, F. (2014) The hallmarks of fibroblast ageing. Mech Ageing Dev. 138, 26-44. IF: 3.264
  • Schuler, D., Sansone, R., Freudenberger, T., Rodriguez-Mateos, A., Weber, G., Momma, T., Goy, C., Altschmied, J., Haendeler, J., Fischer, J.W., Kelm, M., Heiss, C. (2014) Measurement of endothelium-dependent vasodilation in mice. Arterioscler. Thromb. Vasc. Biol. 34, 2651-2657. IF: 6.338
  • Büchner, N.*, Ale-Agha, N.*, Jakob, S.*, Sydlik, U., Kunze, K., Unfried, K., Altschmied, J., Haendeler, J. (2013) Unhealthy diet and ultrafine carbon black particles induce senescence and disease associated phenotypic changes. Exp. Gerontol. 48, 8-16. IF: 3.529
  • Zschauer, T.-C., Matsushima, S., Altschmied, J., Shao, D., Sadoshima, J., Haendeler, J. (2013) Interacting with Thioredoxin-1 – disease or no disease? Antioxid. Redox. Signal. 18, 1053-1062. IF: 8.456
  • Stolzing, A., Haendeler, J. (2013) Aging-mechanisms, models, and translation. Z. Gerontol. Geriat. 46, 612. IF: 1.023
  • Czypiorski, P., Rabanter, L.L., Altschmied, J., Haendeler, J. (2013) Redox balance in the aged endothelium. Z. Gerontol. Geriat. 46, 635-638. IF: 1.023
  • Haendeler, J.*#, Mlynek, A.#, Büchner, N.#, Lukosz, M., Graf, M., Güttler, C., Jakob, S., Farrokh, S., Kunze, K., Goy, C., Guardiola-Serrano, F., Schaal, H., Cortese-Krott, M., Deenen, R., Köhrer, K., Winkler, C., Altschmied, J.* (2013) Two isoforms of Sister-of-Mammalian-Grainyhead have opposing functions in endothelial cells and in vivo. Arterioscler. Thromb. Vasc. Biol. 33, 1639-1646 (* corresponding authors; # contributed equally). IF: 6.338
  • Shao, D., Oka, S.I., Brady, C.D., Haendeler, J., Eaton, P., Sadoshima, J. (2012) Redox modification of cell signaling in the cardiovascular system. J. Mol. Cell. Cardiol. 52, 550-558. IF: 5.5
  • Eckers, A., Altschmied, J., Haendeler, J. (2012) Oxidative stress in endothelial cells and in diabetes type 2. Z. Gerontol. Geriat. 45, 90-94. IF: 0.613
  • Haendeler, J., Eckers, A., Lukosz, M., Unfried, K., Altschmied, J. (2012) Endothelial NADPH oxidase 2 - when does it matter in atherosclerosis? Cardiovasc. Res. 94, 1-2. IF: 6.065
  • Peuschel, H., Sydlik, U., Grether-Beck, S., Felsner, I., Stöckmann, D., Jakob, S., Kroker, M., Haendeler, J., Gotic, M., Bieschke, C., Krutmann, J., Unfried, K. (2012) Carbon nanoparticles induce ceramide- and lipid raft-dependent signalling in lung epithelial cells: a target for a preventive strategy against environmentally-induced lung inflammation. Part. Fibre Toxicol. 48. IF: 7.25
  • Zschauer, T.-C., Kunze, K., Jakob, S., Haendeler, J.*#, Altschmied, J.# (2011) Oxidative stress induced degradation of Thioredoxin-1 and apoptosis is inhibited by Thioredoxin-1/actin interaction in endothelial cells. Arterioscler. Thromb. Vasc. Biol., 31, 650-656 (* corresponding author; # contributed equally). IF: 7.235
  • Werner, C., Gensch, C., Pöss, J., Haendeler, J., Böhm, M., Laufs, U. (2011) Pioglitazone activates aortic telomerase and prevents stress-induced endothelial apoptosis. Atheroslerosis, 216, 23-34. IF: 4.225
  • Lukosz, M.*, Mlynek, A.*, Czypiorski, P., Altschmied, J., Haendeler, J. (2011) The transcription factor Grainyhead-like 3 (GRHL3) a new player in endothelial cell senescence, apoptosis and migration. Biochem. Biophys. Res. Commun. 412, 648-653 (*contributed equally). IF: 2.595
  • Lukosz, M.*, Jakob, S.*, Büchner, N., Zschauer, T.-C., Altschmied, J., Haendeler, J. (2010) Nuclear redox signaling. Antioxid. Redox Signal., 12, 713-742. (*contributed equally) IF: 7.581
  • Seeger, F.H., Sedding, D., Langheinrich, A.C., Haendeler, J., Zeiher, A.M., Dimmeler, S. (2010) Inhibition of p38 MAP kinase in vivo improves number and functional activity of vasculogenic cells and reduces atherosclerotic disease progression. Basic. Res. Cardiol., 110, 389-397. IF: 5.973
  • Büchner, N.*, Altschmied, J.*, Jakob, S., Saretzki, G., Haendeler, J. (2010) Well-known signalling proteins with new functions in the nucleus and mitochondria. Antioxid. Redox Signal., 13, 551-558. (*contributed equally) IF: 7.581
  • Büchner, N., Zschauer, T.-C., Lukosz, M., Altschmied, J.*, Haendeler, J.* (2010) Downregulation of mitochondrial Telomerase Reverse Transcriptase induced by H2O2 is Src kinase dependent. Exp Gerontol., 45, 558-562. (*contributed equally) IF: 3.342
  • Peuschel, H*, Sydlik, U.*, Haendeler, J., Büchner, N., Stoeckmann, D., Kroker, M., Wirth, R., Brock, W., Unfried, K. (2010) c-Src-mediated activation of Erk1/2 is a reaction of epithelial cells on carbon nanoparticle treatment and may be a target for a molecular preventive strategy. Biol. Chem., 391, 1327-1332. (*contributed equally) IF: 2.732
  • Entschladen, F., Altschmied, J., Baumgrass, R., Behrmann, I., Giehl, K., Hermanns, H., Huber, O., Kieser, A., Klotz, L.O., Kubatzky, K.F., Hass, R., Janssen, O., Friedrich, K. (2010) Signal transduction, receptors, mediators and genes: younger than ever - the 13th meeting of the Signal Transduction Society focused on aging and immunology. Cell Commun Signal. 11, 2.
  • Altschmied, J., Haendeler, J. (2009). Thioredoxin-1 and endothelial cell aging: Role in cardiovascular diseases. Antioxid. Redox Signal., 11, 1733-1740. IF: 7.581
  • Haendeler, J., Droese, S., Buechner, N., Altschmied, J., Jakob, S., Goy, C., Spyridopoulos, I., Zeiher, A.M., Brandt, U., Dimmeler, S. (2009) Mitochondrial TERT protects mitochondrial DNA and function in vitro and in vivo. Arterioscler. Thromb. Vasc. Biol., 29, 929-935. IF: 7.235
  • Sopjani, M., Föller, M., Haendeler, J., Goetz, F., Lang, F. (2009) Silver ion induced suicidal erythrocyte death. J. Appl Toxicol., 29, 531-536. IF: 2.073
  • Jakob, S., Altschmied, J.*, Haendeler, J.* (2009) “Shping 2” different cellular localizations - a potential new player in aging processes. Aging, 1, 664-668. (*contributed equally) IF: 3.576
  • Werner, C., Fürster, T., Widmann, T., Pöss, J., Roggia, C., Hanhoun, M., Scharhag, J., Büchner, N., Meyer, T., Kindermann, W., Haendeler, J., Böhm, M., Laufs, U. (2009) Physical exercise prevents cellular senescence in circulating leukocytes and in the vessel wall. Circulation, 120, 2438-2447. IF:14.816
  • De-Zolt, S., Altschmied, J., Ruiz, P., von Melchner, H., Schnütgen, F. (2009) Gene-trap vectors and mutagenesis. Methods Mol Biol. 2009, 29-47.
  • Haendeler, J, Klotz LO. (2008) Highlight: oxidative stress and senescence. Biol Chem., 389, 201. IF: 1.779
  • Werner, C., Hanhoun, M., Widmann, T., Kazakov, A., Semenov, A., Pöss, J., Bauersachs, J., Thum, T., Pfreundschuh, M., Müller, P., Haendeler, J., Böhm, M., Laufs, U. (2008) Effects of physical exercise on myocardial telomere-regulating proteins, survival pathways, and apoptosis. J. Am. Coll. Cardiol., 52, 470-482. IF: 12.535
  • Guardiola-Serrano, F.*, Haendeler, J.*, Lukosz, M, Sturm, K., von Melchner, H., Altschmied, J. (2008) Gene trapping identifies a putative tumor suppressor and a new inducer of cell migration. Biochem. Biophys. Res. Commun., 376, 748-752.(*contributed equally) IF: 2.548
  • Altschmied, J., Haendeler, J. (2008) A new kid on the block: PKD1 - a promising target for anti-angiogenic therapy? Arterioscler Thromb Vasc Biol., 28, 1689-1690. IF: 7.235
  • Spyridopoulos, I., Fichtlscherer, S., Popp, R., Toennes, S.W., Fisslthaler, B., Trepels, T., Zernecke, A., Liehn, E.A., Weber, C., Zeiher, A.M., Dimmeler, S., Haendeler, J. (2008) Caffeine Enhances Endothelial Repair by an AMPK-Dependent Mechanism. Arterioscler. Thromb. Vasc. Biol., 28, 1967-1974. IF: 7.235
  • Jakob, S., Schroeder, P., Lukosz, M., Büchner, N., Spyridopoulos, I., Altschmied, J.*, Haendeler, J.* (2008) Nuclear protein tyrosine phosphatase Shp-2 is one important negative regulator of nuclear export of telomerase reverse transcriptase. J. Biol. Chem., 283, 33155-33161. (*contributed equally) IF: 5.328
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