Publications Group Sies


Heiss C, Rodriguez-Mateos A, Bapir M, Skene SS, Sies H, Kelm M. Flow-mediated dilation reference values for evaluation of endothelial function and cardiovascular health. Cardiovasc Res. 2023 Mar 17;119(1):283-293. doi: 10.1093/cvr/cvac095. PMID: 35709326.


Davies MJ, Davies KJA, Halliwell B, Jackson MJ, Mann GE, Poli G, Radi R, Riley PA, Sies H, Ward JF, Wardman P, Willson J. In memoriam: Emeritus Professor Robin L. Willson.

Free Radic Res. 2022 Jul-Aug;56(7-8):572-576. doi: 10.1080/10715762.2022.2140273. Epub 2023 Jan 16. PMID: 36288479.


Sies H, Belousov VV, Chandel NS, Davies MJ, Jones DP, Mann GE, Murphy MP, Yamamoto M, Winterbourn C. Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology. Nat Rev Mol Cell Biol. 2022 Jul;23(7):499-515. doi: 10.1038/s41580-022-00456-z. Epub 2022 Feb 21. PMID: 35190722.


Sies H, Ursini F. Homeostatic control of redox status and health. IUBMB Life. 2022 Jan;74(1):24-28. doi: 10.1002/iub.2519. Epub 2021 Jul 6. PMID: 34227739.

Polidori MC, Sies H, Ferrucci L, Benzing T. COVID-19 mortality as a fingerprint of biological age. Ageing Res Rev. 2021 Feb 20;67:101308. doi: 10.1016/j.arr.2021.101308. Epub ahead of print. PMID: 33621704.

Sies H. Oxidative eustress: On constant alert for redox homeostasis. Redox Biol. 2021 Jan 20;41:101867. doi: 10.1016/j.redox.2021.101867. Epub ahead of print. PMID: 33657525.


Sies H. Oxidative stress: eustress and distress, pp.1-844, San Diego, Academic Press 2020.

Sies, H. Oxidative eustress and oxidative distress: Introductory remarks, in: Oxidative stress: eustress and distress, Sies, ed., pp.3-12, San Diego, Academic Press 2020.

Sies, H. Schrödingers Koffer. BIOspektrum 26, 345-346, 2020

Sies H. Findings in redox biology: From H2O2 to oxidative stress. J Biol Chem. 2020 Sep 25;295(39):13458-13473. doi: 10.1074/jbc.X120.015651. PMID: 32978328.

Sies H. Oxidative Stress: Concept and Some Practical Aspects. Antioxidants (Basel). 2020 Sep 10;9(9):852. doi: 10.3390/antiox9090852. PMID: 32927924.

Stahl W., Sies H. Nutritional protection against photooxidative stress in human skin and eye, in: Oxidative stress: eustress and distress, Sies, ed., pp.389-402, San Diego, Academic Press 2020.

Sies H, Parnham MJ. Potential therapeutic use of ebselen for COVID-19 and other respiratory viral infections. Free Radic Biol Med. 2020 Aug 20;156:107-112. doi: 10.1016/j.freeradbiomed.2020.06.032. Epub 2020 Jun 26. PMID: 32598985.

Sies H, Jones DP. Reactive oxygen species (ROS) as pleiotropic physiological signalling agents. Nat Rev Mol Cell Biol. 2020 Jul;21(7):363-383. doi: 10.1038/s41580-020-0230-3. Epub 2020 Mar 30. PMID: 32231263.


Sies H, Reichert A (2019). Selectively addressing mitochondrial glutathione and thioredoxin redox systems. Cell Chem Biol. 26-3, 316-318. PMID: 30901559

Steinbrenner H, Micoogullari M, Hoang NA, Bergheim I, Klotz LO, Sies H (2019). "Selenium-binding protein 1 (SELENBP1) is a marker of mature adipocytes." Redox Biology 20, 489-495. PMID: 30469030


Cadenas E, Sies H (2018). Lester Packer: On his life and his legacy. Free Radic Biol Med 126, III-X.

Ermakova YG, Pak VV, Bogdanova YA, Kotlobay AA, Yampolsky IV, Shokhina AG, Panova AS, Marygin RA, Staroverov DB, Bilan DS, Sies H, Belousov VV (2018). "SypHer3s: a genetically encoded fluorescent ratiometric probe with enhanced brightness and an improved dynamic range." Chem. Commun. 54, 2898-2901. PMID: 29497715

Koppenol WH, Sies H. (2018). Two centuries since discovery of down-of-life molecule. Nature 559, 181. PMID: 29991793

Sies H. (2018). On the History of Oxidative Stress: Concept and some Aspects of Current Development. Curr. Opin. Toxicol. 7, 122-126. DOI


Sies H. (2017). Gesellschaft für Biochemie und Molekularbiologie: der GBM zum 70-Jahre-Jubiläum 1947-2017. BIOspektrum 23, 574-577.

Sies H, Feinendegen LE (2017). "Radiation Hormesis: The Link to Nanomolar Hydrogen Peroxide." Antioxid Redox Signal. 27:596-598. PMID: 28699353

Siegrist J, Sies H. (2017). Disturbed Redox Homeostasis in Oxidative Distress: A Molecular Link From Chronic Psychosocial Work Stress to Coronary Heart Disease? Circ Res. 121:103-105. PMID: 28684621

Martin, W.F., Sies, H. (2017). Physiological evolution: genomic redox footprints. Nat Plants. 3:17071. PMID: 28504660

Sies H, Berndt C, Jones DP. (2017). Oxidative Stress. Annu. Revs. Biochem. 86, 715-748. PMID: 28441057

Sies H. (2017).  Hydrogen peroxide as a central redox signalling molecule in physiological oxidative stress: oxidative eustress. Redox Biol. 11, 613-619. PMID: 28110218


Sies H. (2016). "The Concept of Oxidative Stress After 30 Years." Gelpi R., Boveris A., Poderoso J. (eds) Biochemistry of Oxidative Stress. Advances in Biochemistry in Health and Disease, vol 16. Springer, Cham, pp.3-11. DOI

Morand C, Sies H (2016). "Special Issue:  Polyphenols and Health." Arch. Biochem. Biophys. 599, 1-2. PMID: 26997173

Sies H (2016) ."German-Japanese relationships in biochemistry: a personal perspective." Nagoya J. Med.Sci. 78, 335-347. PMID: 28008189

De Spirt S, Eckers A, Wehrend C, Micoogullari M, Sies H, Stahl W, Steinbrenner H (2016). "Interplay between the chalcone cardamonin and selenium in the biosynthesis of Nrf2-regulated antioxidant enzymes in intestinal Caco-2 cells." Free Rad. Biol. Med. 91, 164-171. PMID: 26698667


Sies H (2015). "Oxidative stress: impact in redox biology and medicine." Arch. Med. Biomed. Res. 2, 146-150. PMID: 25588755

Jones, D. P., Sies, H. (2015). "The Redox Code". Antioxid Redox Signal. PMID 25891126


Dkhil, M. A., A. A. Abdel-Baki, F. Wunderlich, H. Sies and S. Al-Quraishy (2014). "Dietary selenium affects intestinal development of Eimeria papillata in mice." Parasitol Res 113(1): 267-274. PMID: 24221886

Mano, C. M., F. M. Prado, J. Massari, G. E. Ronsein, G. R. Martinez, S. Miyamoto, J. Cadet, H. Sies, M. H. Medeiros, E. J. Bechara and P. Di Mascio (2014). "Excited singlet molecular O2 ((1)Deltag) is generated enzymatically from excited carbonyls in the dark." Sci Rep 4: 5938. PMID: 25087485

Pompella, A., H. Sies, R. Wacker, F. Brouns, T. Grune, H. K. Biesalski and J. Frank (2014). "The use of total antioxidant capacity as surrogate marker for food quality and its effect on health is to be discouraged." Nutrition 30(7-8): 791-793. PMID: 24984994

Rajalin, A. M., M. Micoogullari, H. Sies and H. Steinbrenner (2014). "Upregulation of the thioredoxin-dependent redox system during differentiation of 3T3-L1 cells to adipocytes." Biol Chem 395(6): 667-677. PMID: 24516001

Sies, H. (2014). "Role of metabolic H2O2 generation: redox signaling and oxidative stress." J Biol Chem 289(13): 8735-8741. PMID: 24515117

Speckmann, B., H. J. Bidmon, A. Borchardt, H. Sies and H. Steinbrenner (2014). "Intestinal selenoprotein P in epithelial cells and in plasma cells." Arch Biochem Biophys 541: 30-36. PMID: 24157689

Terao, J. and H. Sies (2014). "Special issue "polyphenols and health"." Arch Biochem Biophys 559: 1-2. PMID: 24953178


Blumberg, J. B., T. A. Camesano, A. Cassidy, P. Kris-Etherton, A. Howell, C. Manach, L. M. Ostertag, H. Sies, A. Skulas-Ray and J. A. Vita (2013). "Cranberries and their bioactive constituents in human health." Adv Nutr 4(6): 618-632. PMID: 24228191

Haussinger, D. and H. Sies (2013). "Hepatic encephalopathy: clinical aspects and pathogenetic concept." Arch Biochem Biophys 536(2): 97-100. PMID: 23643660

Parnham, M. J. and H. Sies (2013). "The early research and development of ebselen." Biochem Pharmacol 86(9): 1248-1253. PMID: 24012716

Steinbrenner, H., A. L. Hotze, B. Speckmann, A. Pinto, H. Sies, M. Schott, M. Ehlers, W. A. Scherbaum and S. Schinner (2013). "Localization and regulation of pancreatic selenoprotein P." J Mol Endocrinol 50(1): 31-42. PMID: 23125459

Steinbrenner, H. and H. Sies (2013). "Selenium homeostasis and antioxidant selenoproteins in brain: implications for disorders in the central nervous system." Arch Biochem Biophys 536(2): 152-157. PMID: 23500141

Steinbrenner, H., B. Speckmann and H. Sies (2013). "Toward understanding success and failures in the use of selenium for cancer prevention." Antioxid Redox Signal 19(2): 181-191. PMID: 23421468

von Lintig, J. and H. Sies (2013). "Carotenoids." Arch Biochem Biophys 539(2): 99-101. PMID: 24076362


Chapple, I. L., M. R. Milward, N. Ling-Mountford, P. Weston, K. Carter, K. Askey, G. E. Dallal, S. De Spirt, H. Sies, D. Patel and J. B. Matthews (2012). "Adjunctive daily supplementation with encapsulated fruit, vegetable and berry juice powder concentrates and clinical periodontal outcomes: a double-blind RCT." J Clin Periodontol 39(1): 62-72. PMID: 22093005

De Spirt, S., H. Sies, H. Tronnier and U. Heinrich (2012). "An encapsulated fruit and vegetable juice concentrate increases skin microcirculation in healthy women." Skin Pharmacol Physiol 25(1): 2-8. PMID: 21822034

Pinto, A., D. T. Juniper, M. Sanil, L. Morgan, L. Clark, H. Sies, M. P. Rayman and H. Steinbrenner (2012). "Supranutritional selenium induces alterations in molecular targets related to energy metabolism in skeletal muscle and visceral adipose tissue of pigs." J Inorg Biochem 114: 47-54. PMID: 22694857

Sies, H., P. C. Hollman, T. Grune, W. Stahl, H. K. Biesalski and G. Williamson (2012). "Protection by flavanol-rich foods against vascular dysfunction and oxidative damage: 27th Hohenheim Consensus Conference." Adv Nutr 3(2): 217-221. PMID: 22516731

Stahl, W. and H. Sies (2012). "beta-Carotene and other carotenoids in protection from sunlight." Am J Clin Nutr 96(5): 1179S-1184S. PMID: 23053552

Stahl, W. and H. Sies (2012). "Photoprotection by dietary carotenoids: concept, mechanisms, evidence and future development." Mol Nutr Food Res 56(2): 287-295. PMID: 21953695


Al-Quraishy, S., D. Delic, H. Sies, F. Wunderlich, A. A. Abdel-Baki and M. A. Dkhil (2011). "Differential miRNA expression in the mouse jejunum during garlic treatment of Eimeria papillata infections." Parasitol Res 109(2): 387-394. PMID: 21301871

Brossette, T., C. Hundsdorfer, K. D. Kroncke, H. Sies and W. Stahl (2011). "Direct evidence that (-)-epicatechin increases nitric oxide levels in human endothelial cells." Eur J Nutr 50(7): 595-599. PMID: 21327831

Dkhil, M., A. A. Abdel-Baki, D. Delic, F. Wunderlich, H. Sies and S. Al-Quraishy (2011). "Eimeria papillata: upregulation of specific miRNA-species in the mouse jejunum." Exp Parasitol 127(2): 581-586. PMID: 21093440

Dkhil, M. A., A. S. Abdel-Baki, F. Wunderlich, H. Sies and S. Al-Quraishy (2011). "Anticoccidial and antiinflammatory activity of garlic in murine Eimeria papillata infections." Vet Parasitol 175(1-2): 66-72. PMID: 20943319

Erhardt, A., W. Stahl, H. Sies, F. Lirussi, A. Donner and D. Haussinger (2011). "Plasma levels of vitamin E and carotenoids are decreased in patients with Nonalcoholic Steatohepatitis (NASH)." Eur J Med Res 16(2): 76-78. PMID: 21463986

Hollman, P. C., A. Cassidy, B. Comte, M. Heinonen, M. Richelle, E. Richling, M. Serafini, A. Scalbert, H. Sies and S. Vidry (2011). "The biological relevance of direct antioxidant effects of polyphenols for cardiovascular health in humans is not established." J Nutr 141(5): 989S-1009S. PMID: 21451125

Pinto, A., B. Speckmann, M. Heisler, H. Sies and H. Steinbrenner (2011). "Delaying of insulin signal transduction in skeletal muscle cells by selenium compounds." J Inorg Biochem 105(6): 812-820. PMID: 21497580

Sies, H. (2011). "Tribute to Professor Minor J. Coon." Arch Biochem Biophys 507(1): 3. PMID: 21324388

Sies, H. (2011). "Use of isolated liver perfusion in metabolic studies: ground-laying work in experimental hepatology." Z Gastroenterol 49(6): 737-739. PMID: 21638240

Speckmann, B., H. J. Bidmon, A. Pinto, M. Anlauf, H. Sies and H. Steinbrenner (2011). "Induction of glutathione peroxidase 4 expression during enterocytic cell differentiation." J Biol Chem 286(12): 10764-10772. PMID: 21252226

Steinbrenner, H., B. Speckmann, A. Pinto and H. Sies (2011). "High selenium intake and increased diabetes risk: experimental evidence for interplay between selenium and carbohydrate metabolism." J Clin Biochem Nutr 48(1): 40-45. PMID: 21297910


Bartholome, A., A. Kampkotter, S. Tanner, H. Sies and L. O. Klotz (2010). "Epigallocatechin gallate-induced modulation of FoxO signaling in mammalian cells and C. elegans: FoxO stimulation is masked via PI3K/Akt activation by hydrogen peroxide formed in cell culture." Arch Biochem Biophys 501(1): 58-64. PMID: 20513639

Li, L., R. S. Willets, M. C. Polidori, W. Stahl, G. Nelles, H. Sies and H. R. Griffiths (2010). "Oxidative LDL modification is increased in vascular dementia and is inversely associated with cognitive performance." Free Radic Res 44(3): 241-248. PMID: 20166891

Pirev, E., Y. Ince, H. Sies and K. D. Kroncke (2010). "Heat shock but not cold shock leads to disturbed intracellular zinc homeostasis." J Cell Physiol 223(1): 103-109. PMID: 20039271

Sies, H. (2010). "Polyphenols and health: update and perspectives." Arch Biochem Biophys 501(1): 2-5. PMID: 20398620

Speckmann, B., A. Pinto, M. Winter, I. Forster, H. Sies and H. Steinbrenner (2010). "Proinflammatory cytokines down-regulate intestinal selenoprotein P biosynthesis via NOS2 induction." Free Radic Biol Med 49(5): 777-785. PMID: 20542496


Ale-Agha, N., S. Galban, C. Sobieroy, K. Abdelmohsen, M. Gorospe, H. Sies and L. O. Klotz (2009). "HuR regulates gap junctional intercellular communication by controlling beta-catenin levels and adherens junction integrity." Hepatology 50(5): 1567-1576. PMID: 19676129

Camera, E., A. Mastrofrancesco, C. Fabbri, F. Daubrawa, M. Picardo, H. Sies and W. Stahl (2009). "Astaxanthin, canthaxanthin and beta-carotene differently affect UVA-induced oxidative damage and expression of oxidative stress-responsive enzymes." Exp Dermatol 18(3): 222-231. PMID: 18803658

De Spirt, S., W. Stahl, H. Tronnier, H. Sies, M. Bejot, J. M. Maurette and U. Heinrich (2009). "Intervention with flaxseed and borage oil supplements modulates skin condition in women." Br J Nutr 101(3): 440-445. PMID: 18761778

Haussinger, D. and H. Sies (2009). "Highlight: 'regenerative hepatology'." Biol Chem 390(10): 949-950. PMID: 19764897

Polidori, M. C., J. C. Carrillo, P. E. Verde, H. Sies, J. Siegrist and W. Stahl (2009). "Plasma micronutrient status is improved after a 3-month dietary intervention with 5 daily portions of fruits and vegetables: implications for optimal antioxidant levels." Nutr J 8: 10. PMID: 19208246

Polidori, M. C., D. Pratico, F. Mangialasche, E. Mariani, O. Aust, T. Anlasik, N. Mang, L. Pientka, W. Stahl, H. Sies, P. Mecocci and G. Nelles (2009). "High fruit and vegetable intake is positively correlated with antioxidant status and cognitive performance in healthy subjects." J Alzheimers Dis 17(4): 921-927. PMID: 19542607

Sies, H. (2009). "Highlight: molecular and cellular mechanisms of memory." Biol Chem 390(11): 1085. PMID: 19803817

Speckmann, B., H. Sies and H. Steinbrenner (2009). "Attenuation of hepatic expression and secretion of selenoprotein P by metformin." Biochem Biophys Res Commun 387(1): 158-163. PMID: 19576170

Steinbrenner, H. and H. Sies (2009). "Protection against reactive oxygen species by selenoproteins." Biochim Biophys Acta 1790(11): 1478-1485. PMID: 19268692

Williamson, G., H. Sies, D. Heber, C. L. Keen, I. A. Macdonald, L. Actis-Goretta, T. Y. Momma, J. I. Ottaviani, R. R. Holt, H. Schroeter and C. Heiss (2009). "Functional foods for health promotion: state-of-the-science on dietary flavonoids. Extended abstracts from the 12th Annual Conference on Functional Foods for Health Promotion, April 2009." Nutr Rev 67(12): 736-743. PMID: 19941619


Bellei, B., A. Mastrofrancesco, S. Briganti, N. Aspite, N. Ale-Agha, H. Sies and M. Picardo (2008). "Ultraviolet A induced modulation of gap junctional intercellular communication by P38 MAPK activation in human keratinocytes." Exp Dermatol 17(2): 115-124. PMID: 18047584

Pirev, E., C. Calles, P. Schroeder, H. Sies and K. D. Kroncke (2008). "Ultraviolet-A irradiation but not ultraviolet-B or infrared-A irradiation leads to a disturbed zinc homeostasis in cells." Free Radic Biol Med 45(1): 86-91. PMID: 18454944

Schewe, T., Y. Steffen and H. Sies (2008). "How do dietary flavanols improve vascular function? A position paper." Arch Biochem Biophys 476(2): 102-106. PMID: 18358827

Schnorr, O., T. Brossette, T. Y. Momma, P. Kleinbongard, C. L. Keen, H. Schroeter and H. Sies (2008). "Cocoa flavanols lower vascular arginase activity in human endothelial cells in vitro and in erythrocytes in vivo." Arch Biochem Biophys 476(2): 211-215. PMID: 18348861

Spalteholz, H., P. G. Furtmuller, C. Jakopitsch, C. Obinger, T. Schewe, H. Sies and J. Arnhold (2008). "Kinetic evidence for rapid oxidation of (-)-epicatechin by human myeloperoxidase." Biochem Biophys Res Commun 371(4): 810-813. PMID: 18466756

Speckmann, B., P. L. Walter, L. Alili, R. Reinehr, H. Sies, L. O. Klotz and H. Steinbrenner (2008). "Selenoprotein P expression is controlled through interaction of the coactivator PGC-1alpha with FoxO1a and hepatocyte nuclear factor 4alpha transcription factors." Hepatology 48(6): 1998-2006. PMID: 18972406

Steffen, Y., C. Gruber, T. Schewe and H. Sies (2008). "Mono-O-methylated flavanols and other flavonoids as inhibitors of endothelial NADPH oxidase." Arch Biochem Biophys 469(2): 209-219. PMID: 17996190

Werth, C., D. Stuhlmann, B. Cat, H. Steinbrenner, L. Alili, H. Sies and P. Brenneisen (2008). "Stromal resistance of fibroblasts against oxidative damage: involvement of tumor cell-secreted platelet-derived growth factor (PDGF) and phosphoinositide 3-kinase (PI3K) activation." Carcinogenesis 29(2): 404-410. PMID: 18174235


Abdelmohsen, K., E. Sauerbier, N. Ale-Agha, J. Beier, P. Walter, S. Galban, D. Stuhlmann, H. Sies and L. O. Klotz (2007). "Epidermal growth factor- and stress-induced loss of gap junctional communication is mediated by ERK-1/ERK-2 but not ERK-5 in rat liver epithelial cells." Biochem Biophys Res Commun 364(2): 313-317. PMID: 17945186

Cronauer, M. V., Y. Ince, R. Engers, L. Rinnab, W. Weidemann, C. V. Suschek, M. Burchardt, H. Kleinert, J. Wiedenmann, H. Sies, R. Ackermann and K. D. Kroncke (2007). "Nitric oxide-mediated inhibition of androgen receptor activity: possible implications for prostate cancer progression." Oncogene 26(13): 1875-1884. PMID: 16983333

Heiss, C., D. Finis, P. Kleinbongard, A. Hoffmann, T. Rassaf, M. Kelm and H. Sies (2007). "Sustained increase in flow-mediated dilation after daily intake of high-flavanol cocoa drink over 1 week." J Cardiovasc Pharmacol 49(2): 74-80. PMID: 17312446

Kagemann, G., H. Sies and O. Schnorr (2007). "Limited availability of L-arginine increases DNA-binding activity of NF-kappaB and contributes to regulation of iNOS expression." J Mol Med (Berl) 85(7): 723-732. PMID: 17340133

Neukam, K., W. Stahl, H. Tronnier, H. Sies and U. Heinrich (2007). "Consumption of flavanol-rich cocoa acutely increases microcirculation in human skin." Eur J Nutr 46(1): 53-56. PMID: 17164979

Peterson, L. A., T. Wagener, H. Sies and W. Stahl (2007). "Decomposition of S-nitrosocysteine via S- to N-transnitrosation." Chem Res Toxicol 20(5): 721-723. PMID: 17439249

Polidori, M. C., D. Pratico, B. Parente, E. Mariani, R. Cecchetti, Y. Yao, H. Sies, P. Cao, P. Mecocci and W. Stahl (2007). "Elevated lipid peroxidation biomarkers and low antioxidant status in atherosclerotic patients with increased carotid or iliofemoral intima media thickness." J Investig Med 55(4): 163-167. PMID: 17651669

Sies, H. (2007). "Biological redox systems and oxidative stress." Cell Mol Life Sci 64(17): 2181-2188. PMID: 17565441

Sies, H. (2007). "Total antioxidant capacity: appraisal of a concept." J Nutr 137(6): 1493-1495. PMID: 17513413

Sies, H. (2007). "How I became a biochemist." IUBMB Life 59(7): 469-473. PMID: 17654124

Stahl, W. and H. Sies (2007). "Carotenoids and flavonoids contribute to nutritional protection against skin damage from sunlight." Mol Biotechnol 37(1): 26-30. PMID: 17914160

Steffen, Y., T. Schewe and H. Sies (2007). "(-)-Epicatechin elevates nitric oxide in endothelial cells via inhibition of NADPH oxidase." Biochem Biophys Res Commun 359(3): 828-833. PMID: 17560937

Steffen, Y., T. Jung, L. O. Klotz, T. Schewe, T. Grune and H. Sies (2007). "Protein modification elicited by oxidized low-density lipoprotein (LDL) in endothelial cells: protection by (-)-epicatechin." Free Radic Biol Med 42(7): 955-970. PMID: 17349924

Steinbrenner, H., L. Alili, D. Stuhlmann, H. Sies and P. Brenneisen (2007). "Post-translational processing of selenoprotein P: implications of glycosylation for its utilisation by target cells." Biol Chem 388(10): 1043-1051. PMID: 17937618

Waterman, M. R., P. Fitzpatrick, T. Scarpa and H. Sies (2007). "Highlight issue: enzymology of drug metabolism and toxicology." Arch Biochem Biophys 464(2): 153-154. PMID: 17693151


Beier, J. I., C. von Montfort, H. Sies and L. O. Klotz (2006). "Activation of ErbB2 by 2-methyl-1,4-naphthoquinone (menadione) in human keratinocytes: role of EGFR and protein tyrosine phosphatases." FEBS Lett 580(7): 1859-1864. PMID: 16516204

Cat, B., D. Stuhlmann, H. Steinbrenner, L. Alili, O. Holtkotter, H. Sies and P. Brenneisen (2006). "Enhancement of tumor invasion depends on transdifferentiation of skin fibroblasts mediated by reactive oxygen species." J Cell Sci 119(Pt 13): 2727-2738. PMID: 16757516

Engers, R., E. Springer, V. Kehren, T. Simic, D. A. Young, J. Beier, L. O. Klotz, I. M. Clark, H. Sies and H. E. Gabbert (2006). "Rac upregulates tissue inhibitor of metalloproteinase-1 expression by redox-dependent activation of extracellular signal-regulated kinase signaling." FEBS J 273(20): 4754-4769. PMID: 16984397

Heinrich, U., K. Neukam, H. Tronnier, H. Sies and W. Stahl (2006). "Long-term ingestion of high flavanol cocoa provides photoprotection against UV-induced erythema and improves skin condition in women." J Nutr 136(6): 1565-1569. PMID: 16702322

Heiss, C., H. Schroeter, J. Balzer, P. Kleinbongard, S. Matern, H. Sies and M. Kelm (2006). "Endothelial function, nitric oxide, and cocoa flavanols." J Cardiovasc Pharmacol 47 Suppl 2: S128-135; discussion S172-126. PMID: 16794450

Kuhn, M., R. Wolber, L. Kolbe, O. Schnorr and H. Sies (2006). "Solar-simulated radiation induces secretion of IL-6 and production of isoprostanes in human skin in vivo." Arch Dermatol Res 297(10): 477-479. PMID: 16491351

Nesaretnam, K. and H. Sies (2006). "6th COSTAM/SFRR (ASEAN/Malaysia) International Workshop on Micronutrients, Oxidative Stress, and the Environment." Antioxid Redox Signal 8(11-12): 2175-2177. PMID: 17034360

Schroeter, H., C. Heiss, J. Balzer, P. Kleinbongard, C. L. Keen, N. K. Hollenberg, H. Sies, C. Kwik-Uribe, H. H. Schmitz and M. Kelm (2006). "(-)-Epicatechin mediates beneficial effects of flavanol-rich cocoa on vascular function in humans." Proc Natl Acad Sci U S A 103(4): 1024-1029. PMID: 16418281

Stahl, W., U. Heinrich, O. Aust, H. Tronnier and H. Sies (2006). "Lycopene-rich products and dietary photoprotection." Photochem Photobiol Sci 5(2): 238-242. PMID: 16465309

Steffen, Y., I. Wiswedel, D. Peter, T. Schewe and H. Sies (2006). "Cytotoxicity of myeloperoxidase/nitrite-oxidized low-density lipoprotein toward endothelial cells is due to a high 7beta-hydroxycholesterol to 7-ketocholesterol ratio." Free Radic Biol Med 41(7): 1139-1150. PMID: 16962939

Steffen, Y., T. Schewe and H. Sies (2006). "Myeloperoxidase-mediated LDL oxidation and endothelial cell toxicity of oxidized LDL: attenuation by (-)-epicatechin." Free Radic Res 40(10): 1076-1085. PMID: 17015252

Steinbrenner, H., E. Bilgic, L. Alili, H. Sies and P. Brenneisen (2006). "Selenoprotein P protects endothelial cells from oxidative damage by stimulation of glutathione peroxidase expression and activity." Free Radic Res 40(9): 936-943. PMID: 17015273

Steinbrenner, H., L. Alili, E. Bilgic, H. Sies and P. Brenneisen (2006). "Involvement of selenoprotein P in protection of human astrocytes from oxidative damage." Free Radic Biol Med 40(9): 1513-1523. PMID: 16632112

Suschek, C. V., T. Schewe, H. Sies and K. D. Kroncke (2006). "Nitrite, a naturally occurring precursor of nitric oxide that acts like a 'prodrug'." Biol Chem 387(5): 499-506. PMID: 16740120

von Montfort, C., V. S. Sharov, S. Metzger, C. Schoneich, H. Sies and L. O. Klotz (2006). "Singlet oxygen inactivates protein tyrosine phosphatase-1B by oxidation of the active site cysteine." Biol Chem 387(10-11): 1399-1404. PMID: 17081112

von Montfort, C., N. S. Fernau, J. I. Beier, H. Sies and L. O. Klotz (2006). "Extracellular generation of hydrogen peroxide is responsible for activation of EGF receptor by ultraviolet A radiation." Free Radic Biol Med 41(9): 1478-1487. PMID: 17023275

Walter, P. L., A. Kampkotter, A. Eckers, A. Barthel, D. Schmoll, H. Sies and L. O. Klotz (2006). "Modulation of FoxO signaling in human hepatoma cells by exposure to copper or zinc ions." Arch Biochem Biophys 454(2): 107-113. PMID: 16973122


Abdelmohsen, K., C. von Montfort, D. Stuhlmann, P. A. Gerber, U. K. Decking, H. Sies and L. O. Klotz (2005). "Doxorubicin induces EGF receptor-dependent downregulation of gap junctional intercellular communication in rat liver epithelial cells." Biol Chem 386(3): 217-223. PMID: 15843167

Anlasik, T., H. Sies, H. R. Griffiths, P. Mecocci, W. Stahl and M. C. Polidori (2005). "Dietary habits are major determinants of the plasma antioxidant status in healthy elderly subjects." Br J Nutr 94(5): 639-642. PMID: 16277763

Aust, O., W. Stahl, H. Sies, H. Tronnier and U. Heinrich (2005). "Supplementation with tomato-based products increases lycopene, phytofluene, and phytoene levels in human serum and protects against UV-light-induced erythema." Int J Vitam Nutr Res 75(1): 54-60. PMID: 15830922

Azzi, A., R. Brigelius-Flohe, F. Kelly, J. K. Lodge, N. Ozer, L. Packer and H. Sies (2005). "On the opinion of the European Commission "Scientific Committee on Food" regarding the tolerable upper intake level of vitamin E (2003)." Eur J Nutr 44(1): 60-62. PMID: 15647855

Brenneisen, P., H. Steinbrenner and H. Sies (2005). "Selenium, oxidative stress, and health aspects." Mol Aspects Med 26(4-5): 256-267. PMID: 16105679

Daubrawa, F., H. Sies and W. Stahl (2005). "Astaxanthin diminishes gap junctional intercellular communication in primary human fibroblasts." J Nutr 135(11): 2507-2511. PMID: 16251602

Hathcock, J. N., A. Azzi, J. Blumberg, T. Bray, A. Dickinson, B. Frei, I. Jialal, C. S. Johnston, F. J. Kelly, K. Kraemer, L. Packer, S. Parthasarathy, H. Sies and M. G. Traber (2005). "Vitamins E and C are safe across a broad range of intakes." Am J Clin Nutr 81(4): 736-745. PMID: 15817846

Heiss, C., P. Kleinbongard, A. Dejam, S. Perre, H. Schroeter, H. Sies and M. Kelm (2005). "Acute consumption of flavanol-rich cocoa and the reversal of endothelial dysfunction in smokers." J Am Coll Cardiol 46(7): 1276-1283. PMID: 16198843

Kalai, T., G. Mugesh, G. Roy, H. Sies, Z. Berente and K. Hideg (2005). "Combining benzo[d]isoselenazol-3-ones with sterically hindered alicyclic amines and nitroxides: enhanced activity as glutathione peroxidase mimics." Org Biomol Chem 3(19): 3564-3569. PMID: 16172695

Melchheier, I., C. von Montfort, D. Stuhlmann, H. Sies and L. O. Klotz (2005). "Quinone-induced Cdc25A inhibition causes ERK-dependent connexin phosphorylation." Biochem Biophys Res Commun 327(4): 1016-1023. PMID: 15652497

Polidori, M. C., D. Pratico, T. Ingegni, E. Mariani, L. Spazzafumo, P. Del Sindaco, R. Cecchetti, Y. Yao, S. Ricci, A. Cherubini, W. Stahl, H. Sies, U. Senin, P. Mecocci and A. S. Group (2005). "Effects of vitamin C and aspirin in ischemic stroke-related lipid peroxidation: results of the AVASAS (Aspirin Versus Ascorbic acid plus Aspirin in Stroke) Study." Biofactors 24(1-4): 265-274. PMID: 16403987

Schewe, T. and H. Sies (2005). "Myeloperoxidase-induced lipid peroxidation of LDL in the presence of nitrite. Protection by cocoa flavanols." Biofactors 24(1-4): 49-58. PMID: 16403963

Schnorr, O., M. Schuier, G. Kagemann, R. Wolf, M. Walz, T. Ruzicka, E. Mayatepek, M. Laryea, C. V. Suschek, V. Kolb-Bachofen and H. Sies (2005). "Arginase-1 overexpression induces cationic amino acid transporter-1 in psoriasis." Free Radic Biol Med 38(8): 1073-1079. PMID: 15780765

Schroeder, P., N. Voevodskaya, L. O. Klotz, P. Brenneisen, A. Graslund and H. Sies (2005). "Loss of the tyrosyl radical in mouse ribonucleotide reductase by (-)-epicatechin." Biochem Biophys Res Commun 326(3): 614-617. PMID: 15596143

Schuier, M., H. Sies, B. Illek and H. Fischer (2005). "Cocoa-related flavonoids inhibit CFTR-mediated chloride transport across T84 human colon epithelia." J Nutr 135(10): 2320-2325. PMID: 16177189

Sies, H., W. Stahl and A. Sevanian (2005). "Nutritional, dietary and postprandial oxidative stress." J Nutr 135(5): 969-972. PMID: 15867266

Sies, H., T. Schewe, C. Heiss and M. Kelm (2005). "Cocoa polyphenols and inflammatory mediators." Am J Clin Nutr 81(1 Suppl): 304S-312S. PMID: 15640495

Stahl, W. and H. Sies (2005). "Bioactivity and protective effects of natural carotenoids." Biochim Biophys Acta 1740(2): 101-107. PMID: 15949675

Steffen, Y., T. Schewe and H. Sies (2005). "Epicatechin protects endothelial cells against oxidized LDL and maintains NO synthase." Biochem Biophys Res Commun 331(4): 1277-1283. PMID: 15883014

Steinbrenner, H., M. C. Ramos, D. Stuhlmann, D. Mitic, H. Sies and P. Brenneisen (2005). "Tumor promoter TPA stimulates MMP-9 secretion from human keratinocytes by activation of superoxide-producing NADPH oxidase." Free Radic Res 39(3): 245-253. PMID: 15788229


Abdelmohsen, K., P. Patak, C. Von Montfort, I. Melchheier, H. Sies and L. O. Klotz (2004). "Signaling effects of menadione: from tyrosine phosphatase inactivation to connexin phosphorylation." Methods Enzymol 378: 258-272. PMID: 15038974

Kraemer, T., I. Prakosay, R. A. Date, H. Sies and T. Schewe (2004). "Oxidative modification of low-density lipoprotein: lipid peroxidation by myeloperoxidase in the presence of nitrite." Biol Chem 385(9): 809-818. PMID: 15493876

Mahns, A., R. Wolber, F. Stab, L. O. Klotz and H. Sies (2004). "Contribution of UVB and UVA to UV-dependent stimulation of cyclooxygenase-2 expression in artificial epidermis." Photochem Photobiol Sci 3(3): 257-262. PMID: 14993941

Oh, J. H., A. S. Chung, H. Steinbrenner, H. Sies and P. Brenneisen (2004). "Thioredoxin secreted upon ultraviolet A irradiation modulates activities of matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 in human dermal fibroblasts." Arch Biochem Biophys 423(1): 218-226. PMID: 14871484

Packer, L., A. Azzi, K. Kraemer, N. Ozer, H. Sies, E. Niki, F. Violi and G. Vatassery (2004). "Future directions in preclinical vitamin E research: panel discussion A." Ann N Y Acad Sci 1031: 305-312. PMID: 15753156

Polidori, M. C., P. Mattioli, S. Aldred, R. Cecchetti, W. Stahl, H. Griffiths, U. Senin, H. Sies and P. Mecocci (2004). "Plasma antioxidant status, immunoglobulin g oxidation and lipid peroxidation in demented patients: relevance to Alzheimer disease and vascular dementia." Dement Geriatr Cogn Disord 18(3-4): 265-270. PMID: 15286458

Ramos, M. C., H. Steinbrenner, D. Stuhlmann, H. Sies and P. Brenneisen (2004). "Induction of MMP-10 and MMP-1 in a squamous cell carcinoma cell line by ultraviolet radiation." Biol Chem 385(1): 75-86. PMID: 14977049

Sies, H. (2004). "Ozone in arteriosclerotic plaques: searching for the "smoking gun"." Angew Chem Int Ed Engl 43(27): 3514-3515. PMID: 15293239

Sies, H. and W. Stahl (2004). "Carotenoids and UV protection." Photochem Photobiol Sci 3(8): 749-752. PMID: 15295630

Sies, H. and W. Stahl (2004). "Nutritional protection against skin damage from sunlight." Annu Rev Nutr 24: 173-200. PMID: 15189118

Stuhlmann, D., H. Steinbrenner, B. Wendlandt, D. Mitic, H. Sies and P. Brenneisen (2004). "Paracrine effect of TGF-beta1 on downregulation of gap junctional intercellular communication between human dermal fibroblasts." Biochem Biophys Res Commun 319(2): 321-326. PMID: 15178409

Traulsen, H., H. Steinbrenner, D. P. Buchczyk, L. O. Klotz and H. Sies (2004). "Selenoprotein P protects low-density lipoprotein against oxidation." Free Radic Res 38(2): 123-128. PMID: 15104205

Wiswedel, I., D. Hirsch, S. Kropf, M. Gruening, E. Pfister, T. Schewe and H. Sies (2004). "Flavanol-rich cocoa drink lowers plasma F(2)-isoprostane concentrations in humans." Free Radic Biol Med 37(3): 411-421. PMID: 15223075


Abdelmohsen, K., P. A. Gerber, C. von Montfort, H. Sies and L. O. Klotz (2003). "Epidermal growth factor receptor is a common mediator of quinone-induced signaling leading to phosphorylation of connexin-43: role of glutathione and tyrosine phosphatases." J Biol Chem 278(40): 38360-38367. PMID: 12874275

Aust, O., N. Ale-Agha, L. Zhang, H. Wollersen, H. Sies and W. Stahl (2003). "Lycopene oxidation product enhances gap junctional communication." Food Chem Toxicol 41(10): 1399-1407. PMID: 12909274

Betancor-Fernandez, A., A. Perez-Galvez, H. Sies and W. Stahl (2003). "Screening pharmaceutical preparations containing extracts of turmeric rhizome, artichoke leaf, devil's claw root and garlic or salmon oil for antioxidant capacity." J Pharm Pharmacol 55(7): 981-986. PMID: 12906755

Buchczyk, D. P., T. Grune, H. Sies and L. O. Klotz (2003). "Modifications of glyceraldehyde-3-phosphate dehydrogenase induced by increasing concentrations of peroxynitrite: early recognition by 20S proteasome." Biol Chem 384(2): 237-241. PMID: 12675516

Giles, G. I., F. H. Fry, K. M. Tasker, A. L. Holme, C. Peers, K. N. Green, L. O. Klotz, H. Sies and C. Jacob (2003). "Evaluation of sulfur, selenium and tellurium catalysts with antioxidant potential." Org Biomol Chem 1(23): 4317-4322. PMID: 14685335

Heinrich, U., C. Gartner, M. Wiebusch, O. Eichler, H. Sies, H. Tronnier and W. Stahl (2003). "Supplementation with beta-carotene or a similar amount of mixed carotenoids protects humans from UV-induced erythema." J Nutr 133(1): 98-101. PMID: 12514275

Heiss, C., A. Dejam, P. Kleinbongard, T. Schewe, H. Sies and M. Kelm (2003). "Vascular effects of cocoa rich in flavan-3-ols." JAMA 290(8): 1030-1031. PMID: 12941674

Jacob, C., G. I. Giles, N. M. Giles and H. Sies (2003). "Sulfur and selenium: the role of oxidation state in protein structure and function." Angew Chem Int Ed Engl 42(39): 4742-4758. PMID: 14562341

Josch, C., L. O. Klotz and H. Sies (2003). "Identification of cytosolic leucyl aminopeptidase (EC as the major cysteinylglycine-hydrolysing activity in rat liver." Biol Chem 384(2): 213-218. PMID: 12675513

Klotz, L. O. and H. Sies (2003). "Defenses against peroxynitrite: selenocompounds and flavonoids." Toxicol Lett 140-141: 125-132. PMID: 12676458

Klotz, L. O., K. D. Kroncke, D. P. Buchczyk and H. Sies (2003). "Role of copper, zinc, selenium and tellurium in the cellular defense against oxidative and nitrosative stress." J Nutr 133(5 Suppl 1): 1448S-1451S. PMID: 12730440

Klotz, L. O., K. D. Kroncke and H. Sies (2003). "Singlet oxygen-induced signaling effects in mammalian cells." Photochem Photobiol Sci 2(2): 88-94. PMID: 12664966

Kostyuk, V. A., T. Kraemer, H. Sies and T. Schewe (2003). "Myeloperoxidase/nitrite-mediated lipid peroxidation of low-density lipoprotein as modulated by flavonoids." FEBS Lett 537(1-3): 146-150. PMID: 12606047

Mahns, A., I. Melchheier, C. V. Suschek, H. Sies and L. O. Klotz (2003). "Irradiation of cells with ultraviolet-A (320-400 nm) in the presence of cell culture medium elicits biological effects due to extracellular generation of hydrogen peroxide." Free Radic Res 37(4): 391-397. PMID: 12747733

Mugesh, G., L. O. Klotz, W. W. du Mont, K. Becker and H. Sies (2003). "Selenenyl iodide: a new substrate for mammalian thioredoxin reductase." Org Biomol Chem 1(16): 2848-2852. PMID: 12968334

Perez-Galvez, A., H. D. Martin, H. Sies and W. Stahl (2003). "Incorporation of carotenoids from paprika oleoresin into human chylomicrons." Br J Nutr 89(6): 787-793. PMID: 12828795

Polidori, M. C., P. Mecocci, W. Stahl and H. Sies (2003). "Cigarette smoking cessation increases plasma levels of several antioxidant micronutrients and improves resistance towards oxidative challenge." Br J Nutr 90(1): 147-150. PMID: 12844386

Sadik, C. D., H. Sies and T. Schewe (2003). "Inhibition of 15-lipoxygenases by flavonoids: structure-activity relations and mode of action." Biochem Pharmacol 65(5): 773-781. PMID: 12628491

Schroeder, P., L. O. Klotz and H. Sies (2003). "Amphiphilic properties of (-)-epicatechin and their significance for protection of cells against peroxynitrite." Biochem Biophys Res Commun 307(1): 69-73. PMID: 12849982

Sies, H. and W. Stahl (2003). "Non-nutritive bioactive constituents of plants: lycopene, lutein and zeaxanthin." Int J Vitam Nutr Res 73(2): 95-100. PMID: 12747216

Stahl, W. and H. Sies (2003). "Antioxidant activity of carotenoids." Mol Aspects Med 24(6): 345-351. PMID: 14585305

Steinbrenner, H., M. C. Ramos, D. Stuhlmann, H. Sies and P. Brenneisen (2003). "UVA-mediated downregulation of MMP-2 and MMP-9 in human epidermal keratinocytes." Biochem Biophys Res Commun 308(3): 486-491. PMID: 12914776

Stuhlmann, D., N. Ale-Agha, R. Reinehr, H. Steinbrenner, M. C. Ramos, H. Sies and P. Brenneisen (2003). "Modulation of homologous gap junctional intercellular communication of human dermal fibroblasts via a paracrine factor(s) generated by squamous tumor cells." Carcinogenesis 24(11): 1737-1748. PMID: 12949050

Suschek, C. V., O. Schnorr, K. Hemmrich, O. Aust, L. O. Klotz, H. Sies and V. Kolb-Bachofen (2003). "Critical role of L-arginine in endothelial cell survival during oxidative stress." Circulation 107(20): 2607-2614. PMID: 12742995

Suschek, C. V., P. Schroeder, O. Aust, H. Sies, C. Mahotka, M. Horstjann, H. Ganser, M. Murtz, P. Hering, O. Schnorr, K. D. Kroncke and V. Kolb-Bachofen (2003). "The presence of nitrite during UVA irradiation protects from apoptosis." FASEB J 17(15): 2342-2344. PMID: 14525939


Ale-Agha, N., W. Stahl and H. Sies (2002). "(-)-Epicatechin effects in rat liver epithelial cells: stimulation of gap junctional communication and counteraction of its loss due to the tumor promoter 12-O-tetradecanoylphorbol-13-acetate." Biochem Pharmacol 63(12): 2145-2149. PMID: 12110373

Arteel, G. E., L. O. Klotz, D. P. Buchczyk and H. Sies (2002). "Selenoprotein P." Methods Enzymol 347: 121-125. PMID: 11898401

Betancor-Fernandez, A., H. Sies, W. Stahl and M. C. Polidori (2002). "In vitro antioxidant activity of 2,5,7,8-tetramethyl-2-(2'-carboxyethyl)-6-hydroxychroman (alpha-CEHC), a vitamin E metabolite." Free Radic Res 36(8): 915-921. PMID: 12420750

Brenneisen, P., H. Sies and K. Scharffetter-Kochanek (2002). "Ultraviolet-B irradiation and matrix metalloproteinases: from induction via signaling to initial events." Ann N Y Acad Sci 973: 31-43. PMID: 12485830

Brenneisen, P., M. Wlaschek, E. Schwamborn, L. A. Schneider, W. Ma, H. Sies and K. Scharffetter-Kochanek (2002). "Activation of protein kinase CK2 is an early step in the ultraviolet B-mediated increase in interstitial collagenase (matrix metalloproteinase-1; MMP-1) and stromelysin-1 (MMP-3) protein levels in human dermal fibroblasts." Biochem J 365(Pt 1): 31-40. PMID: 12071839

Eichler, O., H. Sies and W. Stahl (2002). "Divergent optimum levels of lycopene, beta-carotene and lutein protecting against UVB irradiation in human fibroblastst." Photochem Photobiol 75(5): 503-506. PMID: 12017476

Jorge, S. A., C. F. Menck, H. Sies, M. R. Osborne, D. H. Phillips, A. Sarasin and A. Stary (2002). "Mutagenic fingerprint of ozone in human cells." DNA Repair (Amst) 1(5): 369-378. PMID: 12509241

Klotz, L. O. and H. Sies (2002). "Reversible conversion of nitroxyl anion to nitric oxide." Methods Enzymol 349: 101-106. PMID: 11912899

Klotz, L. O., P. Schroeder and H. Sies (2002). "Peroxynitrite signaling: receptor tyrosine kinases and activation of stress-responsive pathways." Free Radic Biol Med 33(6): 737-743. PMID: 12208362

Klotz, L. O., P. Patak, N. Ale-Agha, D. P. Buchczyk, K. Abdelmohsen, P. A. Gerber, C. von Montfort and H. Sies (2002). "2-Methyl-1,4-naphthoquinone, vitamin K(3), decreases gap-junctional intercellular communication via activation of the epidermal growth factor receptor/extracellular signal-regulated kinase cascade." Cancer Res 62(17): 4922-4928. PMID: 12208742

Kroncke, K. D., L. O. Klotz, C. V. Suschek and H. Sies (2002). "Comparing nitrosative versus oxidative stress toward zinc finger-dependent transcription. Unique role for NO." J Biol Chem 277(15): 13294-13301. PMID: 11796720

McKim, S. E., A. Konno, E. Gabele, T. Uesugi, M. Froh, H. Sies, R. G. Thurman and G. E. Arteel (2002). "Cocoa extract protects against early alcohol-induced liver injury in the rat." Arch Biochem Biophys 406(1): 40-46. PMID: 12234488

Ostrakhovitch, E. A., M. R. Lordnejad, F. Schliess, H. Sies and L. O. Klotz (2002). "Copper ions strongly activate the phosphoinositide-3-kinase/Akt pathway independent of the generation of reactive oxygen species." Arch Biochem Biophys 397(2): 232-239. PMID: 11795876

Polidori, M. C., A. Cherubini, W. Stahl, U. Senin, H. Sies and P. Mecocci (2002). "Plasma carotenoid and malondialdehyde levels in ischemic stroke patients: relationship to early outcome." Free Radic Res 36(3): 265-268. PMID: 12071344

Polidori, M. C., K. Savino, G. Alunni, M. Freddio, U. Senin, H. Sies, W. Stahl and P. Mecocci (2002). "Plasma lipophilic antioxidants and malondialdehyde in congestive heart failure patients: relationship to disease severity." Free Radic Biol Med 32(2): 148-152. PMID: 11796203

Radosavac, D., P. Graf, M. C. Polidori, H. Sies and W. Stahl (2002). "Tocopherol metabolites 2, 5, 7, 8-tetramethyl-2-(2'-carboxyethyl)-6-hydroxychroman (alpha-CEHC) and 2, 7, 8-trimethyl-2-(2'-carboxyethyl)-6-hydroxychroman (gamma-CEHC) in human serum after a single dose of natural vitamin E." Eur J Nutr 41(3): 119-124. PMID: 12111049

Schewe, T., H. Kuhn and H. Sies (2002). "Flavonoids of cocoa inhibit recombinant human 5-lipoxygenase." J Nutr 132(7): 1825-1829. PMID: 12097654

Schieke, S., H. Stege, V. Kurten, S. Grether-Beck, H. Sies and J. Krutmann (2002). "Infrared-A radiation-induced matrix metalloproteinase 1 expression is mediated through extracellular signal-regulated kinase 1/2 activation in human dermal fibroblasts." J Invest Dermatol 119(6): 1323-1329. PMID: 12485435

Stahl, W. and H. Sies (2002). "Carotenoids and protection against solar UV radiation." Skin Pharmacol Appl Skin Physiol 15(5): 291-296. PMID: 12239422


Al-Mustafa, A. H., H. Sies and W. Stahl (2001). "Sulfur-to-nitrogen transnitrosation: transfer of nitric oxide from S-nitroso compounds to diethanolamine and the role of intermediate sulfur-to-sulfur transnitrosation." Toxicology 163(2-3): 127-136. PMID: 11516522

Arteel, G. E. and H. Sies (2001). "The biochemistry of selenium and the glutathione system." Environ Toxicol Pharmacol 10(4): 153-158. PMID: 21782571

Aust, O., H. Sies, W. Stahl and M. C. Polidori (2001). "Analysis of lipophilic antioxidants in human serum and tissues: tocopherols and carotenoids." J Chromatogr A 936(1-2): 83-93. PMID: 11761008

Bruch-Gerharz, D., W. Stahl, C. D. Gerharz, M. Megahed, T. Wingerath, H. Sies and T. Ruzicka (2001). "Accumulation of the xanthophyll lutein in skin amyloid deposits of systemic amyloidosis (al type)." J Invest Dermatol 116(1): 196-197. PMID: 11168818

Buchczyk, D. P., L. O. Klotz, K. Lang, C. Fritsch and H. Sies (2001). "High efficiency of 5-aminolevulinate-photodynamic treatment using UVA irradiation." Carcinogenesis 22(6): 879-883. PMID: 11375893

Fu, Y., H. Sies and X. G. Lei (2001). "Opposite roles of selenium-dependent glutathione peroxidase-1 in superoxide generator diquat- and peroxynitrite-induced apoptosis and signaling." J Biol Chem 276(46): 43004-43009. PMID: 11562367

Grune, T., L. O. Klotz, J. Gieche, M. Rudeck and H. Sies (2001). "Protein oxidation and proteolysis by the nonradical oxidants singlet oxygen or peroxynitrite." Free Radic Biol Med 30(11): 1243-1253. PMID: 11368922

Junghans, A., H. Sies and W. Stahl (2001). "Macular pigments lutein and zeaxanthin as blue light filters studied in liposomes." Arch Biochem Biophys 391(2): 160-164. PMID: 11437346

Klotz, L. O., N. J. Holbrook and H. Sies (2001). "UVA and singlet oxygen as inducers of cutaneous signaling events." Curr Probl Dermatol 29: 95-113. PMID: 11225205

Kono, H., G. E. Arteel, I. Rusyn, H. Sies and R. G. Thurman (2001). "Ebselen prevents early alcohol-induced liver injury in rats." Free Radic Biol Med 30(4): 403-411. PMID: 11182296

Lang, K., K. Bolsen, W. Stahl, T. Ruzicka, H. Sies, P. Lehmann and C. Fritsch (2001). "The 5-aminolevulinic acid-induced porphyrin biosynthesis in benign and malignant cells of the skin." J Photochem Photobiol B 65(1): 29-34. PMID: 11748002

Mugesh, G., W. W. du Mont and H. Sies (2001). "Chemistry of biologically important synthetic organoselenium compounds." Chem Rev 101(7): 2125-2179. PMID: 11710243

Onat, D., W. Stahl and H. Sies (2001). "Stimulation of gap junctional intercellular communication by thalidomide and thalidomide analogs in human fetal skin fibroblasts (HFFF2) and in rat liver epithelial cells (WB-F344)." Biochem Pharmacol 62(8): 1081-1086. PMID: 11597576

Polidori, M. C., W. Stahl, O. Eichler, I. Niestroj and H. Sies (2001). "Profiles of antioxidants in human plasma." Free Radic Biol Med 30(5): 456-462. PMID: 11182517

Schewe, T., C. Sadik, L. O. Klotz, T. Yoshimoto, H. Kuhn and H. Sies (2001). "Polyphenols of cocoa: inhibition of mammalian 15-lipoxygenase." Biol Chem 382(12): 1687-1696. PMID: 11843182

Schroeder, P., L. O. Klotz, D. P. Buchczyk, C. D. Sadik, T. Schewe and H. Sies (2001). "Epicatechin selectively prevents nitration but not oxidation reactions of peroxynitrite." Biochem Biophys Res Commun 285(3): 782-787. PMID: 11453660

Schroeder, P., H. Zhang, L. O. Klotz, B. Kalyanaraman and H. Sies (2001). "(-)-Epicatechin inhibits nitration and dimerization of tyrosine in hydrophilic as well as hydrophobic environments." Biochem Biophys Res Commun 289(5): 1334-1338. PMID: 11741342

Stahl, W., U. Heinrich, S. Wiseman, O. Eichler, H. Sies and H. Tronnier (2001). "Dietary tomato paste protects against ultraviolet light-induced erythema in humans." J Nutr 131(5): 1449-1451. PMID: 11340098

Stahl, W. and H. Sies (2001). "Effects of carotenoids and retinoids on gap junctional communication." Biofactors 15(2-4): 95-98. PMID: 12016334

Suschek, C. V., K. Briviba, D. Bruch-Gerharz, H. Sies, K. D. Kroncke and V. Kolb-Bachofen (2001). "Even after UVA-exposure will nitric oxide protect cells from reactive oxygen intermediate-mediated apoptosis and necrosis." Cell Death Differ 8(5): 515-527. PMID: 11423912

Wagner, G., K. Stettmaier, W. Bors, H. Sies, E. M. Wagner, A. Reuter and H. Weiher (2001). "Enhanced gamma-glutamyl transpeptidase expression and superoxide production in Mpv17-/- glomerulosclerosis mice." Biol Chem 382(7): 1019-1025. PMID: 11530932


Arteel, G. E., P. Schroeder and H. Sies (2000). "Reactions of peroxynitrite with cocoa procyanidin oligomers." J Nutr 130(8S Suppl): 2100S-2104S. PMID: 10917929

Arteel, G. E., S. Franken, J. Kappler and H. Sies (2000). "Binding of selenoprotein P to heparin: characterization with surface plasmon resonance." Biol Chem 381(3): 265-268. PMID: 10782998

Assmann, A., M. Bonifacic, K. Briviba, H. Sies and K. D. Asmus (2000). "One-electron reduction of selenomethionine oxide." Free Radic Res 32(4): 371-376. PMID: 10741858

Briviba, K. and H. Sies (2000). "Biological singlet oxygen quenchers assessed by monomol light emission." Methods Enzymol 319: 222-226. PMID: 10907514

Buchczyk, D. P., K. Briviba, F. U. Hartl and H. Sies (2000). "Responses to peroxynitrite in yeast: glyceraldehyde-3-phosphate dehydrogenase (GAPDH) as a sensitive intracellular target for nitration and enhancement of chaperone expression and ubiquitination." Biol Chem 381(2): 121-126. PMID: 10746743

Cadenas, E. and H. Sies (2000). "Formation of electronically excited states during the oxidation of arachidonic acid by prostaglandin endoperoxide synthase." Methods Enzymol 319: 67-77. PMID: 10907500

Gladilin, S., H. J. Bidmon, A. Divanach, G. E. Arteel, O. W. Witte, K. Zilles and H. Sies (2000). "Ebselen lowers plasma interleukin-6 levels and glial heme oxygenase-1 expression after focal photothrombotic brain ischemia." Arch Biochem Biophys 380(2): 237-242. PMID: 10933877

Grether-Beck, S., G. Bonizzi, H. Schmitt-Brenden, I. Felsner, A. Timmer, H. Sies, J. P. Johnson, J. Piette and J. Krutmann (2000). "Non-enzymatic triggering of the ceramide signalling cascade by solar UVA radiation." EMBO J 19(21): 5793-5800. PMID: 11060030

Jacob, C., G. E. Arteel, T. Kanda, L. Engman and H. Sies (2000). "Water-soluble organotellurium compounds: catalytic protection against peroxynitrite and release of zinc from metallothionein." Chem Res Toxicol 13(1): 3-9. PMID: 10649960

Junghans, A., H. Sies and W. Stahl (2000). "Carotenoid-containing unilamellar liposomes loaded with glutathione: a model to study hydrophobic-hydrophilic antioxidant interaction." Free Radic Res 33(6): 801-808. PMID: 11237102

Klotz, L. O., K. Briviba and H. Sies (2000). "Mitogen-activated protein kinase activation by singlet oxygen and ultraviolet A." Methods Enzymol 319: 130-143. PMID: 10907506

Klotz, L. O., S. M. Schieke, H. Sies and N. J. Holbrook (2000). "Peroxynitrite activates the phosphoinositide 3-kinase/Akt pathway in human skin primary fibroblasts." Biochem J 352 Pt 1: 219-225. PMID: 11062076

Martinez, G. R., P. Di Mascio, M. G. Bonini, O. Augusto, K. Briviba, H. Sies, P. Maurer, U. Rothlisberger, S. Herold and W. H. Koppenol (2000). "Peroxynitrite does not decompose to singlet oxygen ((1)Delta (g)O(2)) andnitroxyl (NO(-))." Proc Natl Acad Sci U S A 97(19): 10307-10312. PMID: 10973492

Mecocci, P., M. C. Polidori, L. Troiano, A. Cherubini, R. Cecchetti, G. Pini, M. Straatman, D. Monti, W. Stahl, H. Sies, C. Franceschi and U. Senin (2000). "Plasma antioxidants and longevity: a study on healthy centenarians." Free Radic Biol Med 28(8): 1243-1248. PMID: 10889454

Panasenko, O. M., V. S. Sharov, K. Briviba and H. Sies (2000). "Interaction of peroxynitrite with carotenoids in human low density lipoproteins." Arch Biochem Biophys 373(1): 302-305. PMID: 10620353

Parnham, M. and H. Sies (2000). "Ebselen: prospective therapy for cerebral ischaemia." Expert Opin Investig Drugs 9(3): 607-619. PMID: 11060699

Pierlot, C., J. M. Aubry, K. Briviba, H. Sies and P. Di Mascio (2000). "Naphthalene endoperoxides as generators of singlet oxygen in biological media." Methods Enzymol 319: 3-20. PMID: 10907494

Polidori, M. C., P. Mecocci, W. Stahl, B. Parente, R. Cecchetti, A. Cherubini, P. Cao, H. Sies and U. Senin (2000). "Plasma levels of lipophilic antioxidants in very old patients with type 2 diabetes." Diabetes Metab Res Rev 16(1): 15-19. PMID: 10707034

Possel, H., H. Noack, J. Putzke, G. Wolf and H. Sies (2000). "Selective upregulation of inducible nitric oxide synthase (iNOS) by lipopolysaccharide (LPS) and cytokines in microglia: in vitro and in vivo studies." Glia 32(1): 51-59. PMID: 10975910

Sies, H. and G. E. Arteel (2000). "Interaction of peroxynitrite with selenoproteins and glutathione peroxidase mimics." Free Radic Biol Med 28(10): 1451-1455. PMID: 10927168

Stahl, W., J. von Laar, H. D. Martin, T. Emmerich and H. Sies (2000). "Stimulation of gap junctional communication: comparison of acyclo-retinoic acid and lycopene." Arch Biochem Biophys 373(1): 271-274. PMID: 10620348

Stahl, W., U. Heinrich, H. Jungmann, H. Tronnier and H. Sies (2000). "Carotenoids in human skin: noninvasive measurement and identification of dermal carotenoids and carotenol esters." Methods Enzymol 319: 494-502. PMID: 10907537

Stahl, W., U. Heinrich, H. Jungmann, H. Sies and H. Tronnier (2000). "Carotenoids and carotenoids plus vitamin E protect against ultraviolet light-induced erythema in humans." Am J Clin Nutr 71(3): 795-798. PMID: 10702175

Stock, A. and H. Sies (2000). "Thyroid hormone receptors bind to an element in the connexin43 promoter." Biol Chem 381(9-10): 973-979. PMID: 11076030

Arteel, G. E., K. Briviba and H. Sies (1999). "Function of thioredoxin reductase as a peroxynitrite reductase using selenocystine or ebselen." Chem Res Toxicol 12(3): 264-269. PMID: 10077489

Arteel, G. E. and H. Sies (1999). "Protection against peroxynitrite by cocoa polyphenol oligomers." FEBS Lett 462(1-2): 167-170. PMID: 10580113

Arteel, G. E., K. Briviba and H. Sies (1999). "Protection against peroxynitrite." FEBS Lett 445(2-3): 226-230. PMID: 10094462

Ballmaier, D., K. Briviba, H. Sies and B. Epe (1999). "Use of repair endonucleases to assess DNA damage by peroxynitrite." Methods Enzymol 301: 311-318. PMID: 9919580

Berneburg, M., S. Grether-Beck, V. Kurten, T. Ruzicka, K. Briviba, H. Sies and J. Krutmann (1999). "Singlet oxygen mediates the UVA-induced generation of the photoaging-associated mitochondrial common deletion." J Biol Chem 274(22): 15345-15349. PMID: 10336420

Briviba, K., L. O. Klotz and H. Sies (1999). "Defenses against peroxynitrite." Methods Enzymol 301: 301-311. PMID: 9919579

Clairmont, A., H. Sies, S. Ramachandran, J. T. Lear, A. G. Smith, B. Bowers, P. W. Jones, A. A. Fryer and R. C. Strange (1999). "Association of NAD(P)H:quinone oxidoreductase (NQO1) null with numbers of basal cell carcinomas: use of a multivariate model to rank the relative importance of this polymorphism and those at other relevant loci." Carcinogenesis 20(7): 1235-1240. PMID: 10383895

Fritsch, C., P. Lehmann, W. Stahl, K. W. Schulte, E. Blohm, K. Lang, H. Sies and T. Ruzicka (1999). "Optimum porphyrin accumulation in epithelial skin tumours and psoriatic lesions after topical application of delta-aminolaevulinic acid." Br J Cancer 79(9-10): 1603-1608. PMID: 10188913

Ji, Y., T. P. Akerboom, H. Sies and J. A. Thomas (1999). "S-nitrosylation and S-glutathiolation of protein sulfhydryls by S-nitroso glutathione." Arch Biochem Biophys 362(1): 67-78. PMID: 9917330

Ji, Y., T. P. Akerboom, H. Sies and J. A. Thomas (1999). "Gel electrofocusing method for studying protein S-nitrosylation." Methods Enzymol 301: 145-151. PMID: 9919562

Klotz, L. O., C. Pellieux, K. Briviba, C. Pierlot, J. M. Aubry and H. Sies (1999). "Mitogen-activated protein kinase (p38-, JNK-, ERK-) activation pattern induced by extracellular and intracellular singlet oxygen and UVA." Eur J Biochem 260(3): 917-922. PMID: 10103024

Polidori, M. C., P. Mecocci, A. Reimann, A. Cherubini, R. Cecchetti, K. Briviba, W. Stahl, H. Sies and U. Senin (1999). "Plasma lipid peroxidation and vitamin C status in healthy centenarians." J Am Geriatr Soc 47(8): 1038-1039. PMID: 10443874

Schieke, S. M., K. Briviba, L. O. Klotz and H. Sies (1999). "Activation pattern of mitogen-activated protein kinases elicited by peroxynitrite: attenuation by selenite supplementation." FEBS Lett 448(2-3): 301-303. PMID: 10218497

Sharov, V. S., K. Briviba and H. Sies (1999). "Peroxynitrite diminishes gap junctional communication: protection by selenite supplementation." IUBMB Life 48(4): 379-384. PMID: 10632565

Sies, H. (1999). "Glutathione and its role in cellular functions." Free Radic Biol Med 27(9-10): 916-921. PMID: 10569624

Sies, H. (1999). "Paper of the year 1998: award to Karin Post and Martin Pitschke." Biol Chem 380(7-8): 735. PMID: 10494822

Stahl, W., P. Graf, R. Brigelius-Flohe, W. Wechter and H. Sies (1999). "Quantification of the alpha- and gamma-tocopherol metabolites 2,5,7, 8-tetramethyl-2-(2'-carboxyethyl)-6-hydroxychroman and 2,7, 8-trimethyl-2-(2'-carboxyethyl)-6-hydroxychroman in human serum." Anal Biochem 275(2): 254-259. PMID: 10552913

Teicher, V. B., N. Kucharski, H. D. Martin, P. van der Saag, H. Sies and W. Stahl (1999). "Biological activities of Apo-canthaxanthinoic acids related to gap junctional communication." Arch Biochem Biophys 365(1): 150-155. PMID: 10222049

Thiele, J. J., S. N. Hsieh, K. Briviba and H. Sies (1999). "Protein oxidation in human stratum corneum: susceptibility of keratins to oxidation in vitro and presence of a keratin oxidation gradient in vivo." J Invest Dermatol 113(3): 335-339. PMID: 10469330

Arteel, G. E., V. Mostert, H. Oubrahim, K. Briviba, J. Abel and H. Sies (1998). "Protection by selenoprotein P in human plasma against peroxynitrite-mediated oxidation and nitration." Biol Chem 379(8-9): 1201-1205. PMID: 9792455

Assmann, A., K. Briviba and H. Sies (1998). "Reduction of methionine selenoxide to selenomethionine by glutathione." Arch Biochem Biophys 349(1): 201-203. PMID: 9439599

Brenneisen, P., J. Wenk, L. O. Klotz, M. Wlaschek, K. Briviba, T. Krieg, H. Sies and K. Scharffetter-Kochanek (1998). "Central role of Ferrous/Ferric iron in the ultraviolet B irradiation-mediated signaling pathway leading to increased interstitial collagenase (matrix-degrading metalloprotease (MMP)-1) and stromelysin-1 (MMP-3) mRNA levels in cultured human dermal fibroblasts." J Biol Chem 273(9): 5279-5287. PMID: 9478985

Briviba, K., R. Kissner, W. H. Koppenol and H. Sies (1998). "Kinetic study of the reaction of glutathione peroxidase with peroxynitrite." Chem Res Toxicol 11(12): 1398-1401. PMID: 9860480

Briviba, K., R. Tamler, L. O. Klotz, L. Engman, I. A. Cotgreave and H. Sies (1998). "Protection by organotellurium compounds against peroxynitrite-mediated oxidation and nitration reactions." Biochem Pharmacol 55(6): 817-823. PMID: 9586954

Cadenas, E. and H. Sies (1998). "The lag phase." Free Radic Res 28(6): 601-609. PMID: 9736312

Fritsch, C., B. Homey, W. Stahl, P. Lehmann, T. Ruzicka and H. Sies (1998). "Preferential relative porphyrin enrichment in solar keratoses upon topical application of delta-aminolevulinic acid methylester." Photochem Photobiol 68(2): 218-221. PMID: 9723214

Herrmann, G., P. Brenneisen, M. Wlaschek, J. Wenk, K. Faisst, G. Quel, C. Hommel, G. Goerz, T. Ruzicka, T. Krieg, H. Sies and K. Scharffetter-Kochanek (1998). "Psoralen photoactivation promotes morphological and functional changes in fibroblasts in vitro reminiscent of cellular senescence." J Cell Sci 111 ( Pt 6): 759-767. PMID: 9472004

Josch, C., H. Sies and T. P. Akerboom (1998). "Hepatic mercapturic acid formation: involvement of cytosolic cysteinylglycine S-conjugate dipeptidase activity." Biochem Pharmacol 56(6): 763-771. PMID: 9751082

Klotz, L. O., C. Fritsch, K. Briviba, N. Tsacmacidis, F. Schliess and H. Sies (1998). "Activation of JNK and p38 but not ERK MAP kinases in human skin cells by 5-aminolevulinate-photodynamic therapy." Cancer Res 58(19): 4297-4300. PMID: 9766656

Lorper, M., A. Clairmont, C. Carlberg and H. Sies (1998). "Identification of two activating elements in the proximal promoter region of the human glutathione transferase-A1 and -A2 genes." Arch Biochem Biophys 359(1): 122-127. PMID: 9799569

Schulz, W. A., A. Krummeck, I. Rosinger, B. J. Schmitz-Drager and H. Sies (1998). "Predisposition towards urolithiasis associated with the NQO1 null-allele." Pharmacogenetics 8(5): 453-454. PMID: 9825838

Sies, H., L. O. Klotz, V. S. Sharov, A. Assmann and K. Briviba (1998). "Protection against peroxynitrite by selenoproteins." Z Naturforsch C 53(3-4): 228-232. PMID: 9618937

Sies, H. and W. Stahl (1998). "Lycopene: antioxidant and biological effects and its bioavailability in the human." Proc Soc Exp Biol Med 218(2): 121-124. PMID: 9605209

Sies, H., A. L. Dafre, Y. Ji and T. P. Akerboom (1998). "Protein S-thiolation and redox regulation of membrane-bound glutathione transferase." Chem Biol Interact 111-112: 177-185. PMID: 9679553

Sies, H. (1998). "Paper of the Year 1997: Award to Everson Nogoceke." Biol Chem 379(8-9): 939. PMID: 9792426

Sompayrac, L., S. Jane, M. Lorper and H. Sies (1998). "A 47-amino-acid fragment of SV40 T antigen represses transcription from human GSTalpha promoters." Virology 249(2): 275-285. PMID: 9791019

Stahl, W., U. Heinrich, H. Jungmann, J. von Laar, M. Schietzel, H. Sies and H. Tronnier (1998). "Increased dermal carotenoid levels assessed by noninvasive reflection spectrophotometry correlate with serum levels in women ingesting Betatene." J Nutr 128(5): 903-907. PMID: 9567001

Stahl, W. and H. Sies (1998). "The role of carotenoids and retinoids in gap junctional communication." Int J Vitam Nutr Res 68(6): 354-359. PMID: 9857261

Stahl, W., A. Junghans, B. de Boer, E. S. Driomina, K. Briviba and H. Sies (1998). "Carotenoid mixtures protect multilamellar liposomes against oxidative damage: synergistic effects of lycopene and lutein." FEBS Lett 427(2): 305-308. PMID: 9607334

Stock, A., H. Sies and W. Stahl (1998). "Enhancement of gap junctional communication and connexin43 expression by thyroid hormones." Biochem Pharmacol 55(4): 475-479. PMID: 9514082

Wingerath, T., H. Sies and W. Stahl (1998). "Xanthophyll esters in human skin." Arch Biochem Biophys 355(2): 271-274. PMID: 9675037

Akerboom, T. P., Y. Ji, G. Wagner and H. Sies (1997). "Subunit specificity and organ distribution of glutathione transferase-catalysed S-nitrosoglutathione formation from alkyl nitrites in the rat." Biochem Pharmacol 53(1): 117-120. PMID: 8960071

Biesalski, H. K., H. Bohles, H. Esterbauer, P. Furst, F. Gey, G. Hundsdorfer, H. Kasper, H. Sies and J. Weisburger (1997). "Antioxidant vitamins in prevention." Clin Nutr 16(3): 151-155. PMID: 16844591

Briviba, K., L. O. Klotz and H. Sies (1997). "Toxic and signaling effects of photochemically or chemically generated singlet oxygen in biological systems." Biol Chem 378(11): 1259-1265. PMID: 9426185

Clairmont, A. and H. Sies (1997). "Evidence for a posttranscriptional effect of retinoic acid on connexin43 gene expression via the 3'-untranslated region." FEBS Lett 419(2-3): 268-270. PMID: 9428648

Di Mascio, P., K. Briviba, S. T. Sasaki, L. H. Catalani, M. H. Medeiros, E. J. Bechara and H. Sies (1997). "The reaction of peroxynitrite with tert-butyl hydroperoxide produces singlet molecular oxygen." Biol Chem 378(9): 1071-1074. PMID: 9348119

Fritsch, C., C. Abels, A. E. Goetz, W. Stahl, K. Bolsen, T. Ruzicka, G. Goerz and H. Sies (1997). "Porphyrins preferentially accumulate in a melanoma following intravenous injection of 5-aminolevulinic acid." Biol Chem 378(1): 51-57. PMID: 9049065

Gartner, C., W. Stahl and H. Sies (1997). "Lycopene is more bioavailable from tomato paste than from fresh tomatoes." Am J Clin Nutr 66(1): 116-122. PMID: 9209178

Klotz, L. O., K. Briviba and H. Sies (1997). "Singlet oxygen mediates the activation of JNK by UVA radiation in human skin fibroblasts." FEBS Lett 408(3): 289-291. PMID: 9188778

Morita, A., T. Werfel, H. Stege, C. Ahrens, K. Karmann, M. Grewe, S. Grether-Beck, T. Ruzicka, A. Kapp, L. O. Klotz, H. Sies and J. Krutmann (1997). "Evidence that singlet oxygen-induced human T helper cell apoptosis is the basic mechanism of ultraviolet-A radiation phototherapy." J Exp Med 186(10): 1763-1768. PMID: 9362536

Nicolai, S., H. Sies and W. Stahl (1997). "Stimulation of gap junctional intercellular communication by thalidomide and thalidomide analogs in human skin fibroblasts." Biochem Pharmacol 53(10): 1553-1557. PMID: 9260883

Panasenko, O. M., O. O. Panasenko, K. Briviba and H. Sies (1997). "Hypochlorite destroys carotenoids in low density lipoproteins thus decreasing their resistance to peroxidative modification." Biochemistry (Mosc) 62(10): 1140-1145. PMID: 9461636

Panasenko, O. M., K. Briviba, L. O. Klotz and H. Sies (1997). "Oxidative modification and nitration of human low-density lipoproteins by the reaction of hypochlorous acid with nitrite." Arch Biochem Biophys 343(2): 254-259. PMID: 9224738

Schulz, W. A., A. Krummeck, I. Rosinger, P. Eickelmann, C. Neuhaus, T. Ebert, B. J. Schmitz-Drager and H. Sies (1997). "Increased frequency of a null-allele for NAD(P)H: quinone oxidoreductase in patients with urological malignancies." Pharmacogenetics 7(3): 235-239. PMID: 9241663

Sies, H. (1997). "Oxidative stress: oxidants and antioxidants." Exp Physiol 82(2): 291-295. PMID: 9129943

Sies, H. and W. Stahl (1997). "Carotenoids and intercellular communication via gap junctions." Int J Vitam Nutr Res 67(5): 364-367. PMID: 9350479

Sies, H., V. S. Sharov, L. O. Klotz and K. Briviba (1997). "Glutathione peroxidase protects against peroxynitrite-mediated oxidations. A new function for selenoproteins as peroxynitrite reductase." J Biol Chem 272(44): 27812-27817. PMID: 9346926

Sies, H. and H. Masumoto (1997). "Ebselen as a glutathione peroxidase mimic and as a scavenger of peroxynitrite." Adv Pharmacol 38: 229-246. PMID: 8895811

Stahl, W. and H. Sies (1997). "Antioxidant defense: vitamins E and C and carotenoids." Diabetes 46 Suppl 2: S14-18. PMID: 9285493

Stahl, W., S. Nicolai, K. Briviba, M. Hanusch, G. Broszeit, M. Peters, H. D. Martin and H. Sies (1997). "Biological activities of natural and synthetic carotenoids: induction of gap junctional communication and singlet oxygen quenching." Carcinogenesis 18(1): 89-92. PMID: 9054593

von Herbay, A., W. Stahl, C. Niederau and H. Sies (1997). "Vitamin E improves the aminotransferase status of patients suffering from viral hepatitis C: a randomized, double-blind, placebo-controlled study." Free Radic Res 27(6): 599-605. PMID: 9455695

Wlaschek, M., J. Wenk, P. Brenneisen, K. Briviba, A. Schwarz, H. Sies and K. Scharffetter-Kochanek (1997). "Singlet oxygen is an early intermediate in cytokine-dependent ultraviolet-A induction of interstitial collagenase in human dermal fibroblasts in vitro." FEBS Lett 413(2): 239-242. PMID: 9280289

Brenneisen, P., J. Oh, M. Wlaschek, J. Wenk, K. Briviba, C. Hommel, G. Herrmann, H. Sies and K. Scharffetter-Kochanek (1996). "Ultraviolet B wavelength dependence for the regulation of two major matrix-metalloproteinases and their inhibitor TIMP-1 in human dermal fibroblasts." Photochem Photobiol 64(4): 649-657. PMID: 8863471

Brenneisen, P., J. Oh, M. Wlaschek, J. Wenk, K. Briviba, C. Hommel, G. Herrmann, H. Sies and K. Scharffetter-Kochanek (1996). "Ultraviolet B wavelength dependence for the regulation of two major matrix-metalloproteinases and their inhibitor TIMP-1 in human dermal fibroblasts." Photochem Photobiol 64(5): 877-885. PMID: 8931389

Briviba, K., C. R. Saha-Moller, W. Adam and H. Sies (1996). "Formation of singlet oxygen in the thermal decomposition of 3-hydroxymethyl-3,4,4-trimethyl-1,2-dioxetane, a chemical source of triplet-excited ketones." Biochem Mol Biol Int 38(4): 647-651. PMID: 8728092

Briviba, K., I. Roussyn, V. S. Sharov and H. Sies (1996). "Attenuation of oxidation and nitration reactions of peroxynitrite by selenomethionine, selenocystine and ebselen." Biochem J 319 ( Pt 1): 13-15. PMID: 8870642

Clairmont, A., D. Tessman, A. Stock, S. Nicolai, W. Stahl and H. Sies (1996). "Induction of gap junctional intercellular communication by vitamin D in human skin fibroblasts is dependent on the nuclear Induction of gap junctional intercellular communication by vitamin D in human skin fibroblasts is dependent on the nuclear vitamin D receptor." Carcinogenesis 17(6): 1389-1391. PMID: 8681462

Clairmont, A., D. Tessmann and H. Sies (1996). "Analysis of connexin43 gene expression induced by retinoic acid in F9 teratocarcinoma cells." FEBS Lett 397(1): 22-24. PMID: 8941706

Dafre, A. L., H. Sies and T. Akerboom (1996). "Protein S-thiolation and regulation of microsomal glutathione transferase activity by the glutathione redox couple." Arch Biochem Biophys 332(2): 288-294. PMID: 8806737

Di Mascio, P., K. Briviba, E. J. Bechara, M. H. Medeiros and H. Sies (1996). "Reaction of peroxynitrite and hydrogen peroxide to produce singlet molecular oxygen (1deltag)." Methods Enzymol 269: 395-400. PMID: 8791668

Epe, B., D. Ballmaier, I. Roussyn, K. Briviba and H. Sies (1996). "DNA damage by peroxynitrite characterized with DNA repair enzymes." Nucleic Acids Res 24(21): 4105-4110. PMID: 8932358

Gartner, C., W. Stahl and H. Sies (1996). "Preferential increase in chylomicron levels of the xanthophylls lutein and zeaxanthin compared to beta-carotene in the human." Int J Vitam Nutr Res 66(2): 119-125. PMID: 8843986

Grether-Beck, S., S. Olaizola-Horn, H. Schmitt, M. Grewe, A. Jahnke, J. P. Johnson, K. Briviba, H. Sies and J. Krutmann (1996). "Activation of transcription factor AP-2 mediates UVA radiation- and singlet oxygen-induced expression of the human intercellular adhesion molecule 1 gene." Proc Natl Acad Sci U S A 93(25): 14586-14591. PMID: 8962096

Ji, Y., T. P. Akerboom and H. Sies (1996). "Microsomal formation of S-nitrosoglutathione from organic nitrites: possible role of membrane-bound glutathione transferase." Biochem J 313 ( Pt 2): 377-380. PMID: 8573068

Kaufmann, R., T. Wingerath, D. Kirsch, W. Stahl and H. Sies (1996). "Analysis of carotenoids and carotenol fatty acid esters by matrix-assisted laser desorption ionization (MALDI) and MALDI-post-source-decay mass spectrometry." Anal Biochem 238(2): 117-128. PMID: 8660600

Lorper, M., W. A. Schulz, F. Morel, U. Warskulat and H. Sies (1996). "Positive and negative regulatory regions in promoters of human glutathione transferase alpha genes." Biol Chem Hoppe Seyler 377(1): 39-46. PMID: 8929812

Masumoto, H., R. Kissner, W. H. Koppenol and H. Sies (1996). "Kinetic study of the reaction of ebselen with peroxynitrite." FEBS Lett 398(2-3): 179-182. PMID: 8977102

Masumoto, H. and H. Sies (1996). "The reaction of ebselen with peroxynitrite." Chem Res Toxicol 9(1): 262-267. PMID: 8924601

Masumoto, H. and H. Sies (1996). "The reaction of 2-(methylseleno)benzanilide with peroxynitrite." Chem Res Toxicol 9(7): 1057-1062. PMID: 8902259

Muschen, M., H. Sies and W. A. Schulz (1996). "Induction of mouse embryonal carcinoma cell differentiation and activation of the retinoic acid receptor beta 2 promoter by 1,25-dihydroxyvitamin D3." Biol Chem 377(11): 703-710. PMID: 8960371

Roussyn, I., K. Briviba, H. Masumoto and H. Sies (1996). "Selenium-containing compounds protect DNA from single-strand breaks caused by peroxynitrite." Arch Biochem Biophys 330(1): 216-218. PMID: 8651699

Schulz, W. A., P. Eickelmann and H. Sies (1996). "Free radicals in toxicology: redox cycling and NAD(P)H:quinone oxidoreductase." Arch Toxicol Suppl 18: 217-222. PMID: 8678798

Sharov, V. S., K. Briviba and H. Sies (1996). "Assessment of the C-525 laser dye as a chemiluminescence sensitizer for lipid peroxidation in biological membranes: a comparison with chlorophyll-a." Free Radic Biol Med 21(6): 833-843. PMID: 8902529

Sies, H., W. A. Schulz and S. Steenken (1996). "Adjacent guanines as preferred sites for strand breaks in plasmid DNA irradiated with 193 nm and 248 nm UV laser light." J Photochem Photobiol B 32(1-2): 97-102. PMID: 8725057

Stahl, W. and H. Sies (1996). "Lycopene: a biologically important carotenoid for humans?" Arch Biochem Biophys 336(1): 1-9. PMID: 8951028

Stahl, W., M. Hanusch and H. Sies (1996). "4-oxo-retinoic acid is generated from its precursor canthaxanthin and enhances gap junctional communication in 10T1/2 cells." Adv Exp Med Biol 387: 121-128. PMID: 8794203

Traber, M. G. and H. Sies (1996). "Vitamin E in humans: demand and delivery." Annu Rev Nutr 16: 321-347. PMID: 8839930

von Herbay, A., W. Stahl, C. Niederau, J. von Laar, G. Strohmeyer and H. Sies (1996). "Diminished plasma levels of vitamin E in patients with severe viral hepatitis." Free Radic Res 25(6): 461-466. PMID: 8951419

von Laar, J., W. Stahl, K. Bolsen, G. Goerz and H. Sies (1996). "Beta-carotene serum levels in patients with erythropoietic protoporphyria on treatment with the synthetic all-trans isomer or a natural isomeric mixture of beta-carotene." J Photochem Photobiol B 33(2): 157-162. PMID: 8691357

Akerboom, T. P., H. Sies and D. M. Ziegler (1995). "The oxidation of ebselen metabolites to thiol oxidants catalyzed by liver microsomes and perfused rat liver." Arch Biochem Biophys 316(1): 220-226. PMID: 7840620

Antonenkov, V. D. and H. Sies (1995). "Some basic properties of ascorbate-dependent antioxidative-defence factors from rat liver cytosol." Chem Biol Interact 94(3): 169-181. PMID: 7820882

Eickelmann, P., F. Morel, W. A. Schulz and H. Sies (1995). "Turnover of glutathione S-transferase alpha mRNAs is accelerated by 12-O-tetradecanoyl phorbol-13-acetate in human hepatoma and colon carcinoma cell lines." Eur J Biochem 229(1): 21-26. PMID: 7744032

Hanusch, M., W. Stahl, W. A. Schulz and H. Sies (1995). "Induction of gap junctional communication by 4-oxoretinoic acid generated from its precursor canthaxanthin." Arch Biochem Biophys 317(2): 423-428. PMID: 7893159

Muller-Breitkreutz, K., H. Mohr, K. Briviba and H. Sies (1995). "Inactivation of viruses by chemically and photochemically generated singlet molecular oxygen." J Photochem Photobiol B 30(1): 63-70. PMID: 8558363

Nikawa, T., W. A. Schulz, C. E. van den Brink, M. Hanusch, P. van der Saag, W. Stahl and H. Sies (1995). "Efficacy of all-trans-beta-carotene, canthaxanthin, and all-trans-, 9-cis-, and 4-oxoretinoic acids in inducing differentiation of an F9 embryonal carcinoma RAR beta-lacZ reporter cell line." Arch Biochem Biophys 316(2): 665-672. PMID: 7864621

Sies, H. and W. Stahl (1995). "Vitamins E and C, beta-carotene, and other carotenoids as antioxidants." Am J Clin Nutr 62(6 Suppl): 1315S-1321S. PMID: 7495226

Sies, H. and N. I. Krinsky (1995). "The present status of antioxidant vitamins and beta-carotene." Am J Clin Nutr 62(6 Suppl): 1299S-1300S. PMID: 7495222

Sies, H. (1995). "Ebselen." Methods Enzymol 252: 341-342. PMID: 7476371

Soboll, S., S. Grundel, J. Harris, V. Kolb-Bachofen, B. Ketterer and H. Sies (1995). "The content of glutathione and glutathione S-transferases and the glutathione peroxidase activity in rat liver nuclei determined by a non-aqueous technique of cell fractionation." Biochem J 311 ( Pt 3): 889-894. PMID: 7487946

Stahl, W., W. Schwarz, J. von Laar and H. Sies (1995). "All-trans beta-carotene preferentially accumulates in human chylomicrons and very low density lipoproteins compared with the 9-cis geometrical isomer." J Nutr 125(8): 2128-2133. PMID: 7643247

Stremmel, W., H. de Groot, H. Sies and G. Strohmeyer (1995). "[Mechanism of liver damage. Pathogenesis of primary hemochromatosis and auxiliary liver transplantation]." Internist (Berl) 36(4): 362-366. PMID: 7775085

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