Publications Group Anand


Golombek M, Tsigaras T, Schaumkessel Y, Hänsch S, Weidtkamp-Peters S, Anand R, Reichert AS, Kondadi AK. Cristae dynamics is modulated in bioenergetically compromised mitochondria. Life Sci Alliance. 2023 Nov 13;7(2):e202302386. doi: 10.26508/lsa.202302386. PMID: 37957016.

Peifer-Weiß L, Kurban M, David C, Lubeck M, Kondadi AK, Nemer G, Reichert AS, Anand R. A X-linked nonsense APOO/MIC26 variant causes a lethal mitochondrial disease with progeria-like phenotypes. Clin Genet. 2023 Aug 30. doi: 10.1111/cge.14420. Epub ahead of print. PMID: 37649161.

Nakhaei-Rad S, Haghighi F, Bazgir F, Dahlmann J, Busley AV, Buchholzer M, Kleemann K, Schänzer A, Borchardt A, Hahn A, Kötter S, Schanze D, Anand R, Funk F, Kronenbitter AV, Scheller J, Piekorz RP, Reichert AS, Volleth M, Wolf MJ, Cirstea IC, Gelb BD, Tartaglia M, Schmitt JP, Krüger M, Kutschka I, Cyganek L, Zenker M, Kensah G, Ahmadian MR. Molecular and cellular evidence for the impact of a hypertrophic cardiomyopathy-associated RAF1 variant on the structure and function of contractile machinery in bioartificial cardiac tissues. Commun Biol. 2023 Jun 21;6(1):657. doi: 10.1038/s42003-023-05013-8. PMID: 37344639.

Lubeck M, Derkum NH, Naha R, Strohm R, Driessen MD, Belgardt BF, Roden M, Stühler K, Anand R, Reichert AS, Kondadi AK. MIC26 and MIC27 are bona fide subunits of the MICOS complex in mitochondria and do not exist as glycosylated apolipoproteins. PLoS One. 2023 Jun 6;18(6):e0286756. doi: 10.1371/journal.pone.0286756. PMID: 37279200.


Navaratnarajah T, Bellmann M, Seibt A, Anand R, Degistirici Ö, Meisel R, Mayatepek E, Reichert A, Baertling F, Distelmaier F. Mesenchymal stem cells improve redox homeostasis and mitochondrial respiration in fibroblast cell lines with pathogenic MT-ND3 and MT-ND6 variants. Stem Cell Res Ther. 2022 Jun 17;13(1):256. doi: 10.1186/s13287-022-02932-x. PMID: 35715829.


Deitersen J, Berning L, Stuhldreier F, Ceccacci S, Schlütermann D, Friedrich A, Wu W, Sun Y, Böhler P, Berleth N, Mendiburo MJ, Seggewiß S, Anand R, Reichert AS, Monti MC, Proksch P, Stork B. High-throughput screening for natural compound-based autophagy modulators reveals novel chemotherapeutic mode of action for arzanol. Cell Death Dis. 2021 May 31;12(6):560. doi: 10.1038/s41419-021-03830-5. PMID: 34059630.

Urbach J, Kondadi AK, David C, Naha R, Deinert K, Reichert AS, Anand R. Conserved GxxxG and WN motifs of MIC13 are essential for bridging two MICOS subcomplexes. Biochim Biophys Acta Biomembr. 2021 Jul 13:183683. doi: 10.1016/j.bbamem.2021.183683. Epub ahead of print. PMID: 34271005.

Anand R, Reichert AS, Kondadi AK. Emerging Roles of the MICOS Complex in Cristae Dynamics and Biogenesis. Biology (Basel). 2021 Jun 29;10(7):600. doi: 10.3390/biology10070600. PMID: 34209580.

Navaratnarajah T, Anand R, Reichert AS, Distelmaier F. The relevance of mitochondrial morphology for human disease. Int J Biochem Cell Biol. 2021 Feb 18;134:105951. doi: 10.1016/j.biocel.2021.105951. Epub ahead of print. PMID: 33610749.

Viana MP, Levytskyy RM, Anand R, Reichert AS, Khalimonchuk O. Protease OMA1 modulates mitochondrial bioenergetics and ultrastructure through dynamic association with MICOS complex. iScience. 2021 Jan 29;24(2):102119. doi: 10.1016/j.isci.2021.102119. PMID: 33644718.


Kondadi AK, Anand R, Reichert AS. Cristae Membrane Dynamics - A Paradigm Change. Trends Cell Biol. 2020 Dec;30(12):923-936. doi: 10.1016/j.tcb.2020.08.008. Epub 2020 Sep 23. PMID: 32978040.

Anand R, Kondadi AK, Meisterknecht J, Golombek M, Nortmann O, Riedel J, Peifer-Weiß L, Brocke-Ahmadinejad N, Schlütermann D, Stork B, Eichmann TO, Wittig I, and Reichert AS. MIC26 and MIC27 cooperate to regulate cardiolipin levels and the landscape of OXPHOS complexes. Life Sci Alliance. 2020 Aug 11;3(10):e202000711. doi: 10.26508/lsa.202000711. Print 2020 Oct. PMID: 32788226. Press release on EurekAlert

Kondadi AK*, Anand R*, Hänsch S, Urbach J, Zobel T, Wolf DM, Segawa M, Liesa M, Shirihai OS, Weidtkamp-Peters S, Reichert AS. Cristae undergo continuous cycles of membrane remodelling in a MICOS-dependent manner. *equal contribution. EMBO Rep. 2020 Mar4;21(3):e49776. doi: PMID: 32067344. Press release at  HHU.


Wolf DM, Segawa M, Kondadi AK, Anand R, Bailey ST, Reichert AS, van der Bliek AM, Shackelford DB, Liesa M, Shirihai OS. Individual cristae within the same mitochondrion display different membrane potentials and are functionally independent. EMBO J. 2019 Nov 15;38(22):e101056. doi: 10.15252/embj.2018101056. PMID: 31609012.

Kondadi AK, Anand R, Reichert AS. Functional interplay between cristae biogenesis, mitochondrial dynamics and mitochondrial DNA integrity. Int J Mol Sci. 2019 Sep 3;20(17). doi: 10.3390/ijms20174311. PMID:     31484398.


Böhler P*, Stuhldreier F*, Anand R, Kondadi AK, Schlutermann D, Berleth N, Deitersen J, Wallot-Hieke N, Wu W, Frank M, Niemann H, Wesbuer E, Barbian A, Luyten T, Parys JB, Weidtkamp-Peters S, Borchardt A, Reichert AS, Pena-Blanco A, Garcia-Saez AJ, Itskanov S, van der Bliek AM, Proksch P, Wesselborg S, Stork B. The mycotoxin phomoxanthone A disturbs the form and function of the inner mitochondrial membrane. Cell Death Dis. 2018 Feb 19; 9(3): 286. doi: 10.1038/s41419-018-0312-8. PMID: 29459714. *equal contribution


Lang A, Anand R, Altinoluk-Hambuchen S, Ezzahoini H, Stefanski A, Iram A, Bergmann L, Urbach J, Bohler P, Hansel J, Franke M, Stuhler K, Krutmann J, Scheller J, Stork B, Reichert AS, Piekorz RP. SIRT4 interacts with OPA1 and regulates mitochondrial quality control and mitophagy. Aging (Albany NY). 2017 Oct 29;9(10): 2163-2189. doi: 10.18632/aging.101307. PMID: 29081403.


Anand R, Strecker V, Urbach J, Wittig I, Reichert AS. Mic13 Is Essential for Formation of Crista Junctions in Mammalian Cells. PloS One. 2016 Aug 1;11(8):e0160258. doi: 10.1371/journal.pone.0160258. eCollection 2016. PMID: 27479602.


Koob S, Barrera M, Anand R, Reichert AS. The non-glycosylated isoform of MIC26 is a constituent of the mammalian MICOS complex and promotes formation of crista junctions. Biochim Biophys Acta 2015 Jul;1853(7): 1551-63. doi: 10.1016/j.bbamcr.2015.03.004. PMID: 25764979.


Anand R, Wai T, Baker MJ, Kladt N, Schauss AC, Rugarli E, Langer T. The i-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission. J Cell Biol 2014 Mar 17;204(6):919-29. doi: 10.1083/jcb.201308006. PMID: 24616225.

Baker MJ, Lampe PA, Stojanovski D, Korwitz A, Anand R, Tatsuta T, Langer T. Stress-induced OMA1 activation and autocatalytic turnover regulate OPA1-dependent mitochondrial dynamics. EMBO J 2014 Mar 18;33(6):578-93. doi: 10.1002/embj.201386474. PMID: 24550258.


Anand R, Langer T, Baker MJ. Proteolytic control of mitochondrial function and morphogenesis. Biochim Biophys Acta 2013 Jan;1833(1):195-204. doi: 10.1016/j.bbamcr.2012.06.025. PMID: 22749882.

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