Publications Group Pla Martín
2023
Sen A, Boix J, Pla-Martín D. Endosomal-dependent mitophagy coordinates mitochondrial nucleoid and mtDNA elimination. Autophagy. 2023 Sep;19(9):2609-2610. doi: 10.1080/15548627.2023.2170959. Epub 2023 Jan 29. PMID: 36691806.
Pla-Martín D, Babatz F, Schauss AC. Localization of Mitochondrial Nucleoids by Transmission Electron Microscopy Using the Transgenic Expression of the Mitochondrial Helicase Twinkle and APEX2. Methods Mol Biol. 2023;2615:173-188. doi: 10.1007/978-1-0716-2922-2_13. PMID: 36807792.
2022
Sen A, Kallabis S, Gaedke F, Jüngst C, Boix J, Nüchel J, Maliphol K, Hofmann J, Schauss AC, Krüger M, Wiesner RJ, Pla-Martín D. Mitochondrial membrane proteins and VPS35 orchestrate selective removal of mtDNA. Nat Commun. 2022 Nov 7;13(1):6704. doi: 10.1038/s41467-022-34205-9. PMID: 36344526.
Kimoloi S, Sen A, Guenther S, Braun T, Brügmann T, Sasse P, Wiesner RJ, Pla-Martín D, Baris OR. Combined fibre atrophy and decreased muscle regeneration capacity driven by mitochondrial DNA alterations underlie the development of sarcopenia. J Cachexia Sarcopenia Muscle. 2022 Aug;13(4):2132-2145. doi: 10.1002/jcsm.13026. Epub 2022 Jun 28. PMID: 35765148.
2021
Paß T, Wiesner RJ, Pla-Martín D. Selective Neuron Vulnerability in Common and Rare Diseases-Mitochondria in the Focus. Front Mol Biosci. 2021 Jun 30;8:676187. doi: 10.3389/fmolb.2021.676187. PMID: 34295920.
Kimoloi S, Pla-Martín D, Oexner RR, Baris OR, Wiesner RJ. Author Response: K320E-Twinkleskm Mice Are Genetically Heterogeneous for Secondary mtDNA Deletions Impairing Comparison With Controls. Invest Ophthalmol Vis Sci. 2021 Jan 4;62(1):13. doi: 10.1167/iovs.62.1.13. PMID: 33427853.
2020
Oexner RR, Pla-Martín D, Paß T, Wiesen MHJ, Zentis P, Schauss A, Baris OR, Kimoloi S, Wiesner RJ. Extraocular Muscle Reveals Selective Vulnerability of Type IIB Fibers to Respiratory Chain Defects Induced by Mitochondrial DNA Alterations. Invest Ophthalmol Vis Sci. 2020 Oct 1;61(12):14. doi: 10.1167/iovs.61.12.14. PMID: 33057669.
Pla-Martín D, Schatton D, Wiederstein JL, Marx MC, Khiati S, Krüger M, Rugarli EI. CLUH granules coordinate translation of mitochondrial proteins with mTORC1 signaling and mitophagy. EMBO J. 2020 May 4;39(9):e102731. doi: 10.15252/embj.2019102731. Epub 2020 Mar 9. PMID: 32149416.
2019
Pla-Martin D, Wiesner RJ. Reshaping membranes to build mitochondrial DNA. PLoS Genet. 2019 Jun 6;15(6):e1008140. doi: 10.1371/journal.pgen.1008140. PMID: 31170157; PMCID: PMC6553704.
2017
Schatton D, Pla-Martin D, Marx MC, Hansen H, Mourier A, Nemazanyy I, Pessia A, Zentis P, Corona T, Kondylis V, Barth E, Schauss AC, Velagapudi V, Rugarli EI. CLUH regulates mitochondrial metabolism by controlling translation and decay of target mRNAs. J Cell Biol. 2017 Mar 6;216(3):675-693. doi: 10.1083/jcb.201607019. Epub 2017 Feb 10. PMID: 28188211.
González-Sánchez P, Pla-Martín D, Martínez-Valero P, Rueda CB, Calpena E, Del Arco A, Palau F, Satrústegui J. CMT-linked loss-of-function mutations in GDAP1 impair store-operated Ca2+ entry-stimulated respiration. Sci Rep. 2017 Feb 21;7:42993. doi: 10.1038/srep42993. PMID: 28220846.
2015
Barneo-Muñoz M, Juárez P, Civera-Tregón A, Yndriago L, Pla-Martin D, Zenker J, Cuevas-Martín C, Estela A, Sánchez-Aragó M, Forteza-Vila J, Cuezva JM, Chrast R, Palau F. Lack of GDAP1 induces neuronal calcium and mitochondrial defects in a knockout mouse model of charcot-marie-tooth neuropathy. PLoS Genet. 2015 Apr 10;11(4):e1005115. doi: 10.1371/journal.pgen.1005115. PMID: 25860513.
Pla-Martín D, Calpena E, Lupo V, Márquez C, Rivas E, Sivera R, Sevilla T, Palau F, Espinós C. Junctophilin-1 is a modifier gene of GDAP1-related Charcot-Marie-Tooth disease. Hum Mol Genet. 2015 Jan 1;24(1):213-29. doi: 10.1093/hmg/ddu440. Epub 2014 Aug 28. PMID: 25168384.
2014
Gao J, Schatton D, Martinelli P, Hansen H, Pla-Martin D, Barth E, Becker C, Altmueller J, Frommolt P, Sardiello M, Rugarli EI. CLUH regulates mitochondrial biogenesis by binding mRNAs of nuclear-encoded mitochondrial proteins. J Cell Biol. 2014 Oct 27;207(2):213-23. doi: 10.1083/jcb.201403129. PMID: 25349259.
Bolinches-Amorós A, Mollá B, Pla-Martín D, Palau F, González-Cabo P. Mitochondrial dysfunction induced by frataxin deficiency is associated with cellular senescence and abnormal calcium metabolism. Front Cell Neurosci. 2014 May 13;8:124. doi: 10.3389/fncel.2014.00124. PMID: 24860428.
2013
Pla-Martín D, Rueda CB, Estela A, Sánchez-Piris M, González-Sánchez P, Traba J, de la Fuente S, Scorrano L, Renau-Piqueras J, Alvarez J, Satrústegui J, Palau F. Silencing of the Charcot-Marie-Tooth disease-associated gene GDAP1 induces abnormal mitochondrial distribution and affects Ca2+ homeostasis by reducing store-operated Ca2+ entry. Neurobiol Dis. 2013 Jul;55:140-51. doi: 10.1016/j.nbd.2013.03.010. Epub 2013 Mar 28. PMID: 23542510.
2011
Estela A, Pla-Martín D, Sánchez-Piris M, Sesaki H, Palau F. Charcot-Marie-Tooth-related gene GDAP1 complements cell cycle delay at G2/M phase in Saccharomyces cerevisiae fis1 gene-defective cells. J Biol Chem. 2011 Oct 21;286(42):36777-86. doi: 10.1074/jbc.M111.260042. Epub 2011 Sep 2. PMID: 21890626.
Palau F, Estela A, Pla-Martín D, Sánchez-Piris M. The role of mitochondrial network dynamics in the pathogenesis of Charcot-Marie-Tooth disease. Adv Exp Med Biol. 2009;652:129-37. doi: 10.1007/978-90-481-2813-6_9. PMID: 20225023.