Publications Group Kondadi

2023

Golombek M, Tsigaras T, Schaumkessel Y, Hänsch S, Weidtkamp-Peters S, Anand R, Reichert AS, Kondadi AK. Cristae dynamics is modulated in bioenergetically compromised mitochondria. Life Sci Alliance. 2023 Nov 13;7(2):e202302386. doi: 10.26508/lsa.202302386. PMID: 37957016.

Jochims F, Strohm R, von Montfort C, Wenzel C-K, Klahm N, Kondadi AK, Stahl W, Reichert AS, Brenneisen P. The Antimalarial Drug Artesunate Mediates Selective Cytotoxicity by Upregulating HO-1 in Melanoma Cells. Biomedicines. 2023; 11(9):2393. PMID: 37760834.

Peifer-Weiß L, Kurban M, David C, Lubeck M, Kondadi AK, Nemer G, Reichert AS, Anand R. A X-linked nonsense APOO/MIC26 variant causes a lethal mitochondrial disease with progeria-like phenotypes. Clin Genet. 2023 Aug 30. doi: 10.1111/cge.14420. Epub ahead of print. PMID: 37649161.

Molinari PE, Krapp AR, Weiner A, Beyer HM, Kondadi AK, Blomeier T, López M, Bustos-Sanmamed P, Tevere E, Weber W, Reichert AS, Calcaterra NB, Beller M, Carrillo N, Zurbriggen MD. NERNST: a genetically-encoded ratiometric non-destructive sensing tool to estimate NADP(H) redox status in bacterial, plant and animal systems. Nat Commun. 2023 Jun 6;14(1):3277. doi: 10.1038/s41467-023-38739-4. PMID: 37280202.

Lubeck M, Derkum NH, Naha R, Strohm R, Driessen MD, Belgardt BF, Roden M, Stühler K, Anand R, Reichert AS, Kondadi AK. MIC26 and MIC27 are bona fide subunits of the MICOS complex in mitochondria and do not exist as glycosylated apolipoproteins. PLoS One. 2023 Jun 6;18(6):e0286756. doi: 10.1371/journal.pone.0286756. PMID: 37279200.

Haasler L, von Montfort C, Kondadi AK, Golombek M, Ebbert L, Wenzel CK, Stahl W, Reichert AS, Brenneisen P. Involvement of necroptosis in the selective toxicity of the natural compound (±) gossypol on squamous skin cancer cells in vitro. Arch Toxicol. 2023 Jul;97(7):1997-2014. doi: 10.1007/s00204-023-03516-1. Epub 2023 May 21. PMID: 37210688.

2022

Griess K, Rieck M, Müller N, Karsai G, Hartwig S, Pelligra A, Hardt R, Schlegel C, Kuboth J, Uhlemeyer C, Trenkamp S, Jeruschke K, Weiss J, Peifer-Weiss L, Xu W, Cames S, Yi X, Cnop M, Beller M, Stark H, Kondadi AK, Reichert AS, Markgraf D, Wammers M, Häussinger D, Kuss O, Lehr S, Eizirik D, Lickert H, Lammert E, Roden M, Winter D, Al-Hasani H, Höglinger D, Hornemann T, Brüning JC, Belgardt BF. Sphingolipid subtypes differentially control proinsulin processing and systemic glucose homeostasis. Nat Cell Biol. 2022 Dec 21. doi: 10.1038/s41556-022-01027-2. Epub ahead of print. PMID: 36543979.

2021

Urbach J, Kondadi AK, David C, Naha R, Deinert K, Reichert AS, Anand R. Conserved GxxxG and WN motifs of MIC13 are essential for bridging two MICOS subcomplexes. Biochim Biophys Acta Biomembr. 2021 Jul 13:183683. doi: 10.1016/j.bbamem.2021.183683. Epub ahead of print. PMID: 34271005.

Anand R, Reichert AS, Kondadi AK. Emerging Roles of the MICOS Complex in Cristae Dynamics and Biogenesis. Biology (Basel). 2021 Jun 29;10(7):600. doi: 10.3390/biology10070600. PMID: 34209580.

Haasler L, Kondadi AK, Tsigaras T, von Montfort C, Graf P, Stahl W, Brenneisen P. The BH3 mimetic (±) gossypol induces ROS-independent apoptosis and mitochondrial dysfunction in human A375 melanoma cells in vitro. Arch Toxicol. 2021 Feb 1. doi: 10.1007/s00204-021-02987-4. Epub ahead of print. PMID: 33523262.

2020

Kondadi AK, Anand R, Reichert AS. Cristae Membrane Dynamics - A Paradigm Change. Trends Cell Biol. 2020 Dec;30(12):923-936. doi: 10.1016/j.tcb.2020.08.008. Epub 2020 Sep 23. PMID: 32978040.

Anand R, Kondadi AK, Meisterknecht J, Golombek M, Nortmann O, Riedel J, Peifer-Weiß L, Brocke-Ahmadinejad N, Schlütermann D, Stork B, Eichmann TO, Wittig I, and Reichert AS. MIC26 and MIC27 cooperate to regulate cardiolipin levels and the landscape of OXPHOS complexes. Life Sci Alliance. 2020 Aug 11;3(10):e202000711. doi: 10.26508/lsa.202000711. Print 2020 Oct. PMID: 32788226. Press release on EurekAlert

Kondadi AK*, Anand R*, Hänsch S, Urbach J, Zobel T, Wolf DM, Segawa M, Liesa M, Shirihai OS, Weidtkamp-Peters S, Reichert AS. Cristae undergo continuous cycles of membrane remodelling in a MICOS-dependent manner. *equal contribution. EMBO Rep. 2020 Mar4;21(3):e49776. doi: doi.org/10.15252/embr.201949776. PMID: 32067344. Press release at  HHU.

2019

Wolf DM, Segawa M, Kondadi AK, Anand R, Bailey ST, Reichert AS, van der Bliek AM, Shackelford DB, Liesa M, Shirihai OS. Individual cristae within the same mitochondrion display different membrane potentials and are functionally independent. EMBO J. 2019 Nov 15;38(22):e101056. doi: 10.15252/embj.2018101056. PMID: 31609012.

Kondadi AK, Anand R, Reichert AS. Functional interplay between cristae biogenesis, mitochondrial dynamics and mitochondrial DNA integrity. Int J Mol Sci. 2019 Sep 3;20(17). doi: 10.3390/ijms20174311. PMID: 31484398.

2018

Böhler P, Stuhldreier F, Anand R, Kondadi AK, Schlütermann D, Berleth N, Deitersen J, Wallot-Hieke N, Wu W, Frank M, Niemann H, Wesbuer E, Barbian A, Luyten T, Parys JB, Weidtkamp-Peters S, Borchardt A, Reichert AS, Peña-Blanco A, García-Sáez AJ, Itskanov S, van der Bliek AM, Proksch P, Wesselborg S, Stork B. The mycotoxin phomoxanthone A disturbs the form and function of the inner mitochondrial membrane. Cell Death Dis. 2018 Feb 19;9(3):286. doi: 10.1038/s41419-018-0312-8. PMID: 29459714.

2017

Melcher M, Danhauser K, Seibt A, Degistirici Ö, Baertling F, Kondadi AK, Reichert AS, Koopman WJH, Willems PHGM, Rodenburg RJ, Mayatepek E, Meisel R, Distelmaier F. Modulation of oxidative phosphorylation and redox homeostasis in mitochondrial NDUFS4 deficiency via mesenchymal stem cells. Stem Cell Res Ther. 2017 Jun 24;8(1):150. doi: 10.1186/s13287-017-0601-7. PMID: 28646906.

2014

Kondadi AK, Wang S, Montagner S, Kladt N, Korwitz A, Martinelli P, Herholz D, Bajer MJ, Schauss AC, Langer T, Rugarli EI. Loss of the m-AAA Protease Subunit AFG₃L₂ Causes Mitochondrial Transport Defects and Tau Hyperphosphorylation. EMBO J. 2014 May 2;33(9):1011-26. doi: 10.1002/embj.201387009. PMID: 24681487.

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