Publications 2021

ULK1 phosphorylation of striatin activates protein phosphatase 2A and autophagy.
Hu Z, Sankar DS, Vu B, Leytens A, Vionnet C, Wu W, Stumpe M, Martínez-Martínez E, Stork B, Dengjel J. Cell Rep. 2021 Sep 28;36(13):109762. doi: 10.1016/j.celrep.2021.109762. PMID: 3459214

FIP200 controls the TBK1 activation threshold at SQSTM1/p62-positive condensates.
Schlütermann D, Berleth N, Deitersen J, Wallot-Hieke N, Friesen O, Wu W, Stuhldreier F, Sun Y, Berning L, Friedrich A, Mendiburo MJ, Peter C, Wiek C, Hanenberg H, Stefanski A, Stühler K, Stork B.Sci Rep. 2021 Jul 5;11(1):13863. doi: 10.1038/s41598-021-92408-4.PMID: 34226595

An essential role of the autophagy activating kinase ULK1 in snRNP biogenesis.
Schmitz K, Cox J, Esser LM, Voss M, Sander K, Löffler A, Hillebrand F, Erkelenz S, Schaal H, Kähne T, Klinker S, Zhang T, Nagel-Steger L, Willbold D, Seggewiß S, Schlütermann D, Stork B, Grimmler M, Wesselborg S, Peter C. Nucleic Acids Res. 2021 Jun 21;49(11):6437-6455. doi: 10.1093/nar/gkab452. PMID: 34096600

Phosphorylation of GAPVD1 Is Regulated by the PER Complex and Linked to GAPVD1 Degradation.
Ibrahim H, Reus P, Mundorf AK, Grothoff AL, Rudenko V, Buschhaus C, Stefanski A, Berleth N, Stork B, Stühler K, Kalfalah F, Reinke H. Int J Mol Sci. 2021 Apr 6;22(7):3787. doi: 10.3390/ijms22073787. PMID: 33917494

TNF-induced necroptosis initiates early autophagy events via RIPK3-dependent AMPK activation, but inhibits late autophagy.
Wu W, Wang X, Sun Y, Berleth N, Deitersen J, Schlütermann D, Stuhldreier F, Wallot-Hieke N, José Mendiburo M, Cox J, Peter C, Bergmann AK, Stork B. Autophagy. 2021 Dec;17(12):3992-4009. doi: 10.1080/15548627.2021.1899667. Epub 2021 Mar 28. PMID: 33779513

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.
Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, et. al. Autophagy. 2021 Jan;17(1):1-382. doi: 10.1080/15548627.2020.1797280. Epub 2021 Feb 8. PMID: 33634751

Publications 2020

The phospho-barcode of RIPK1: complementarity or redundancy?
Wu W, Stork B. Mol Cell Oncol. 2020 Jul 16;7(5):1776085. doi: 10.1080/23723556.2020.1776085. eCollection 2020. PMID: 32944633

The Autophagy-Initiating Kinase ULK1 Controls RIPK1-Mediated Cell Death.
Wu W, Wang X, Berleth N, Deitersen J, Wallot-Hieke N, Böhler P, Schlütermann D, Stuhldreier F, Cox J, Schmitz K, Seggewiß S, Peter C, Kasof G, Stefanski A, Stühler K, Tschapek A, Gödecke A, Stork B. Cell Rep. 2020 Apr 21;31(3):107547. doi: 10.1016/j.celrep.2020.107547. PMID: 32320653

Publications 2019

Anthraquinones and autophagy - Three rings to rule them all?
Deitersen J, El-Kashef DH, Proksch P, Stork B. Bioorg Med Chem. 2019 Oct 15;27(20):115042. doi: 10.1016/j.bmc.2019.115042. Epub 2019 Aug 8. PMID: 31420258

Novel meriolin derivatives as rapid apoptosis inducers.
Drießen D, Stuhldreier F, Frank A, Stark H, Wesselborg S, Stork B, Müller TJJ.Bioorg Med Chem. 2019 Aug 1;27(15):3463-3468. doi: 10.1016/j.bmc.2019.06.029. Epub 2019 Jun 19. PMID: 31248707

Publications 2018

Multiple DNA damage-dependent and DNA damage-independent stress responses define the outcome of ATR/Chk1 targeting in medulloblastoma cells.
Krüger K, Geist K, Stuhldreier F, Schumacher L, Blümel L, Remke M, Wesselborg S, Stork B, Klöcker N, Bormann S, Roos WP, Honnen S, Fritz G. Cancer Lett. 2018 Aug 28;430:34-46. doi: 10.1016/j.canlet.2018.05.011. Epub 2018 May 16. PMID: 29753759

The mycotoxin phomoxanthone A disturbs the form and function of the inner mitochondrial membrane.
Böhler P, Stuhldreier F, Anand R, Kondadi AK, Schlütermann D, Berleth N, Deitersen J, Wallot-Hieke N, Wu W, Frank M, Niemann H, Wesbuer E, Barbian A, Luyten T, Parys JB, Weidtkamp-Peters S, Borchardt A, Reichert AS, Peña-Blanco A, García-Sáez AJ, Itskanov S, van der Bliek AM, Proksch P, Wesselborg S, Stork B. Cell Death Dis. 2018 Feb 19;9(3):286. doi: 10.1038/s41419-018-0312-8.  PMID: 29459714

EBV Negative Lymphoma and Autoimmune Lymphoproliferative Syndrome Like Phenotype Extend the Clinical Spectrum of Primary Immunodeficiency Caused by STK4 Deficiency.
Schipp C, Schlütermann D, Hönscheid A, Nabhani S, Höll J, Oommen PT, Ginzel S, Fleckenstein B, Stork B, Borkhardt A, Stepensky P, Fischer U. Front Immunol. 2018 Oct 16;9:2400. doi: 10.3389/fimmu.2018.02400. eCollection 2018. PMID: 30386345

Correction: SIRT4 interacts with OPA1 and regulates mitochondrial quality control and mitophagy.
Lang A, Anand R, Altinoluk-Hambüchen S, Ezzahoini H, Stefanski A, Iram A, Bergmann L, Urbach J, Böhler P, Hänsel J, Franke M, Stühler K, Krutmann J, Scheller J, Stork B, Reichert AS, Piekorz RP. Aging (Albany NY). 2018 Sep 28;10(9):2536. doi: 10.18632/aging.101570. No abstract available.  PMID: 30300139

Targeting colorectal cancer cell metabolism through development of cisplatin and metformin nano-cubosomes.
Saber MM, Al-Mahallawi AM, Nassar NN, Stork B, Shouman SA. BMC Cancer. 2018 Aug 15;18(1):822. doi: 10.1186/s12885-018-4727-5. PMID: 30111296

Adenosine enhances cisplatin sensitivity in human ovarian cancer cells.
Sureechatchaiyan P, Hamacher A, Brockmann N, Stork B, Kassack MU. Purinergic Signal. 2018 Dec;14(4):395-408. doi: 10.1007/s11302-018-9622-7. Epub 2018 Aug 4. PMID: 30078088

The ciliary protein RPGRIP1L governs autophagy independently of its proteasome-regulating function at the ciliary base in mouse embryonic fibroblasts.
Struchtrup A, Wiegering A, Stork B, Rüther U, Gerhardt C. Autophagy. 2018;14(4):567-583. doi: 10.1080/15548627.2018.1429874. Epub 2018 Feb 21. PMID: 29372668

Targeting urothelial carcinoma cells by combining cisplatin with a specific inhibitor of the autophagy-inducing class III PtdIns3K complex.
Schlütermann D, Skowron MA, Berleth N, Böhler P, Deitersen J, Stuhldreier F, Wallot-Hieke N, Wu W, Peter C, Hoffmann MJ, Niegisch G, Stork B. Urol Oncol. 2018 Apr;36(4):160.e1-160.e13. doi: 10.1016/j.urolonc.2017.11.021. Epub 2017 Dec 21. PMID: 29276062

Systematic analysis of ATG13 domain requirements for autophagy induction.
Wallot-Hieke N, Verma N, Schlütermann D, Berleth N, Deitersen J, Böhler P, Stuhldreier F, Wu W, Seggewiß S, Peter C, Gohlke H, Mizushima N, Stork B. Autophagy. 2018;14(5):743-763. doi: 10.1080/15548627.2017.1387342. Epub 2018 Mar 21. PMID: 29173006

Publications 2017

Cyclic Cystine-Bridged Peptides from the Marine Sponge Clathria basilana Induce Apoptosis in Tumor Cells and Depolarize the Bacterial Cytoplasmic Membrane.
Mokhlesi A, Stuhldreier F, Wex KW, Berscheid A, Hartmann R, Rehberg N, Sureechatchaiyan P, Chaidir C, Kassack MU, Kalscheuer R, Brötz-Oesterhelt H, Wesselborg S, Stork B, Daletos G, Proksch P. J Nat Prod. 2017 Nov 22;80(11):2941-2952. doi: 10.1021/acs.jnatprod.7b00477. Epub 2017 Nov 2. PMID: 29094598

SIRT4 interacts with OPA1 and regulates mitochondrial quality control and mitophagy.
Lang A, Anand R, Altinoluk-Hambüchen S, Ezzahoini H, Stefanski A, Iram A, Bergmann L, Urbach J, Böhler P, Hänsel J, Franke M, Stühler K, Krutmann J, Scheller J, Stork B, Reichert AS, Piekorz RP. Aging (Albany NY). 2017 Oct 29;9(10):2163-2189. doi: 10.18632/aging.101307. PMID: 29081403

Study of ULK1 Catalytic Activity and Its Regulation.
Stork B, Dengjel J. Methods Enzymol. 2017;587:391-404. doi: 10.1016/bs.mie.2016.09.067. Epub 2016 Nov 18. PMID: 28253968

Publications 2016

Efficient and safe gene delivery to human corneal endothelium using magnetic nanoparticles.
Czugala M, Mykhaylyk O, Böhler P, Onderka J, Stork B, Wesselborg S, Kruse FE, Plank C, Singer BB, Fuchsluger TA. Nanomedicine (Lond). 2016 Jul;11(14):1787-800. doi: 10.2217/nnm-2016-0144. Epub 2016 Jul 7. PMID: 27388974

A systems study reveals concurrent activation of AMPK and mTOR by amino acids.
Dalle Pezze P, Ruf S, Sonntag AG, Langelaar-Makkinje M, Hall P, Heberle AM, Razquin Navas P, van Eunen K, Tölle RC, Schwarz JJ, Wiese H, Warscheid B, Deitersen J, Stork B, Fäßler E, Schäuble S, Hahn U, Horvatovich P, Shanley DP, Thedieck K. Nat Commun. 2016 Nov 21;7:13254. doi: 10.1038/ncomms13254. PMID: 27869123

An siRNA screen for ATG protein depletion reveals the extent of the unconventional functions of the autophagy proteome in virus replication.
Mauthe M, Langereis M, Jung J, Zhou X, Jones A, Omta W, Tooze SA, Stork B, Paludan SR, Ahola T, Egan D, Behrends C, Mokry M, de Haan C, van Kuppeveld F, Reggiori F. J Cell Biol. 2016 Aug 29;214(5):619-35. doi: 10.1083/jcb.201602046. PMID: 27573464

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Klionsky DJ, et al. Autophagy. 2016;12(1):1-222. doi: 10.1080/15548627.2015.1100356. No abstract available. Erratum in: Autophagy. 2016;12(2):443. Selliez, Iban [corrected to Seiliez, Iban]. PMID: 2679965

Publications 2015

Autophagy signal transduction by ATG proteins: from hierarchies to networks.
Wesselborg S, Stork B. Cell Mol Life Sci. 2015 Dec;72(24):4721-57. doi: 10.1007/s00018-015-2034-8. Epub 2015 Sep 21. Review. PMID: 26390974

Expression of a ULK1/2 binding-deficient ATG13 variant can partially restore autophagic activity in ATG13-deficient cells.
Hieke N, Löffler AS, Kaizuka T, Berleth N, Böhler P, Drießen S, Stuhldreier F, Friesen O, Assani K, Schmitz K, Peter C, Diedrich B, Dengjel J, Holland P, Simonsen A, Wesselborg S, Mizushima N, Stork B. Autophagy. 2015;11(9):1471-83. doi: 10.1080/15548627.2015.1068488. PMID: 26213203

Deubiquitinase inhibition by WP1130 leads to ULK1 aggregation and blockade of autophagy.
Drießen S, Berleth N, Friesen O, Löffler AS, Böhler P, Hieke N, Stuhldreier F, Peter C, Schink KO, Schultz SW, Stenmark H, Holland P, Simonsen A, Wesselborg S, Stork B. Autophagy. 2015;11(9):1458-70. doi: 10.1080/15548627.2015.1067359. PMID: 26207339

Phomoxanthone A--From Mangrove Forests to Anticancer Therapy.
Frank M, Niemann H, Böhler P, Stork B, Wesselborg S, Lin W, Proksch P. Curr Med Chem. 2015;22(30):3523-32. Review. PMID: 26179997

Publications 2014

ATG13: just a companion, or an executor of the autophagic program?
Alers S, Wesselborg S, Stork B. Autophagy. 2014 Jun;10(6):944-56. doi: 10.4161/auto.28987. Review. Erratum in: Autophagy. 2014 Aug;10(8):1481. PMID: 24879146

Callyspongiolide, a cytotoxic macrolide from the marine sponge Callyspongia sp.
Pham CD, Hartmann R, Böhler P, Stork B, Wesselborg S, Lin W, Lai D, Proksch P. Org Lett. 2014 Jan 3;16(1):266-9. doi: 10.1021/ol403241v. Epub 2013 Dec 13. PMID: 24329175

PDK1 controls upstream PI3K expression and PIP3 generation.
Dieterle AM, Böhler P, Keppeler H, Alers S, Berleth N, Drießen S, Hieke N, Pietkiewicz S, Löffler AS, Peter C, Gray A, Leslie NR, Shinohara H, Kurosaki T, Engelke M, Wienands J, Bonin M, Wesselborg S, Stork B. Oncogene. 2014 Jun 5;33(23):3043-53. doi: 10.1038/onc.2013.266. Epub 2013 Jul 29. PMID: 23893244

Publications 2013

Pro-apoptotic and immunostimulatory tetrahydroxanthone dimers from the endophytic fungus Phomopsis longicolla.
Rönsberg D, Debbab A, Mándi A, Vasylyeva V, Böhler P, Stork B, Engelke L, Hamacher A, Sawadogo R, Diederich M, Wray V, Lin W, Kassack MU, Janiak C, Scheu S, Wesselborg S, Kurtán T, Aly AH, Proksch P. J Org Chem. 2013 Dec 20;78(24):12409-25. doi: 10.1021/jo402066b. Epub 2013 Dec 11. PMID: 24295452

Vemurafenib potently induces endoplasmic reticulum stress-mediated apoptosis in BRAFV600E melanoma cells.
Beck D, Niessner H, Smalley KS, Flaherty K, Paraiso KH, Busch C, Sinnberg T, Vasseur S, Iovanna JL, Drießen S, Stork B, Wesselborg S, Schaller M, Biedermann T, Bauer J, Lasithiotakis K, Weide B, Eberle J, Schittek B, Schadendorf D, Garbe C, Kulms D, Meier F. Sci Signal. 2013 Jan 29;6(260):ra7. doi: 10.1126/scisignal.2003057. PMID: 23362240

The Dok-3/Grb2 protein signal module attenuates Lyn kinase-dependent activation of Syk kinase in B cell antigen receptor microclusters.
Lösing M, Goldbeck I, Manno B, Oellerich T, Schnyder T, Bohnenberger H, Stork B, Urlaub H, Batista FD, Wienands J, Engelke M. J Biol Chem. 2013 Jan 25;288(4):2303-13. doi: 10.1074/jbc.M112.406546. Epub 2012 Dec 5. PMID: 23223229

Publications 2012

The incredible ULKs.
Alers S, Löffler AS, Wesselborg S, Stork B. Cell Commun Signal. 2012 Mar 13;10(1):7. doi: 10.1186/1478-811X-10-7. PMID: 22413737

Role of AMPK-mTOR-Ulk1/2 in the regulation of autophagy: cross talk, shortcuts, and feedbacks.
Alers S, Löffler AS, Wesselborg S, Stork B. Mol Cell Biol. 2012 Jan;32(1):2-11. doi: 10.1128/MCB.06159-11. Epub 2011 Oct 24. Review. PMID: 22025673

Guidelines for the use and interpretation of assays for monitoring autophagy.
Klionsky DJ, et al. Autophagy. 2012 Apr;8(4):445-544. PMID: 22966490

Publications 2011

Atg13 and FIP200 act independently of Ulk1 and Ulk2 in autophagy induction.
Alers S, Löffler AS, Paasch F, Dieterle AM, Keppeler H, Lauber K, Campbell DG, Fehrenbacher B, Schaller M, Wesselborg S, Stork B. Autophagy. 2011 Dec;7(12):1423-33. PMID 22024743.

Triggering of a novel intrinsic apoptosis pathway by the kinase inhibitor staurosporine: activation of caspase-9 in the absence of Apaf-1.
Manns J, Daubrawa M, Driessen S, Paasch F, Hoffmann N, Löffler A, Lauber K, Dieterle A, Alers S, Iftner T, Schulze-Osthoff K, Stork B, Wesselborg S. FASEB J. 2011 Sep;25(9):3250-61. doi: 10.1096/fj.10-177527. Epub 2011 Jun 9. PMID: 21659556

Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop.
Löffler AS, Alers S, Dieterle AM, Keppeler H, Franz-Wachtel M, Kundu M, Campbell DG, Wesselborg S, Alessi DR, Stork B. Autophagy. 2011 Jul;7(7):696-706. Epub 2011 Jul 1. PMID: 21460634.

Publications 2010

AMPK-independent induction of autophagy by cytosolic Ca2+ increase.
Grotemeier A, Alers S, Pfisterer SG, Paasch F, Daubrawa M, Dieterle A, Viollet B, Wesselborg S, Proikas-Cezanne T, Stork B. Cell Signal. 2010 Jun;22(6):914-25. doi: 10.1016/j.cellsig.2010.01.015. Epub 2010 Jan 28. PMID: 2011407

Publications 2009

Effects of bacterial N-acyl homoserine lactones on human Jurkat T lymphocytes-OdDHL induces apoptosis via the mitochondrial pathway.
Jacobi CA, Schiffner F, Henkel M, Waibel M, Stork B, Daubrawa M, Eberl L, Gregor M, Wesselborg S. Int J Med Microbiol. 2009 Nov;299(7):509-19. doi: 10.1016/j.ijmm.2009.03.005. Epub 2009 May 22. PMID: 19464950

The Akt inhibitor triciribine sensitizes prostate carcinoma cells to TRAIL-induced apoptosis.
Dieterle A, Orth R, Daubrawa M, Grotemeier A, Alers S, Ullrich S, Lammers R, Wesselborg S, Stork B. Int J Cancer. 2009 Aug 15;125(4):932-41.doi: 10.1002/ijc.24374. PMID: 19422047

Publications 2008

Regulation of calcineurin activity in insulin-secreting cells: stimulation by Hsp90 during glucocorticoid-induced apoptosis.
Ranta F, Düfer M, Stork B, Wesselborg S, Drews G, Häring HU, Lang F, Ullrich S. Cell Signal. 2008 Oct;20(10):1780-6. doi: 10.1016/j.cellsig.2008.06.003. Epub 2008 Jun 18. PMID: 18611438

Publications 2007

Interferon-gamma and tumor necrosis factor-alpha sensitize primarily resistant human endometrial stromal cells to Fas-mediated apoptosis.
Fluhr H, Krenzer S, Stein GM, Stork B, Deperschmidt M, Wallwiener D, Wesselborg S, Zygmunt M, Licht P. J Cell Sci. 2007 Dec 1;120(Pt 23):4126-33. Epub 2007 Nov 14. PMID: 18003704

Ca(2+) signaling in antigen receptor-activated B lymphocytes.
Engelke M, Engels N, Dittmann K, Stork B, Wienands J. Immunol Rev. 2007 Aug;218:235-46. Review. PMID: 17624956

Subcellular localization of Grb2 by the adaptor protein Dok-3 restricts the intensity of Ca2+ signaling in B cells.
Stork B, Neumann K, Goldbeck I, Alers S, Kähne T, Naumann M, Engelke M, Wienands J. EMBO J. 2007 Feb 21;26(4):1140-9. Epub 2007 Feb 8. PMID: 17290227

Publications 2004

Grb2 and the non-T cell activation linker NTAL constitute a Ca(2+)-regulating signal circuit in B lymphocytes.
Stork B, Engelke M, Frey J, Horejsí V, Hamm-Baarke A, Schraven B, Kurosaki T, Wienands J. Immunity. 2004 Nov;21(5):681-91. PMID: 15539154