Publications 2024

Novel meriolin derivatives potently inhibit cell cycle progression and transcription in leukemia and lymphoma cells via inhibition of cyclin-dependent kinases (CDKs)
Schmitt L, Hoppe J, Cea-Medina P, Bruch P-M, Krings KS, Lechtenberg I, Drießen D, Peter Ch, Bhatia S, Dietrich S, Stork B, Fritz G, Gohlke H, Müller ThJJ, Wesselborg S. Cell Death Discov. 2024 Jun 11; 10(1):279. PMID: 38862521, doi: 10.1038/s41420-024-02056-6

From the Total Synthesis of Semi-Viriditoxin, Semi-Viriditoxic Acid and Dimeric Naphthopyranones to their Biological Activities in Burkitt B Cell Lymphoma.
Weber F, Weber A, Schmitt L, Lechtenberg I, Greb J, Henßen B, Wesselborg S, Pietruszka J.Chemistry. 2024 Feb 27; e202400559. doi: 10.1002/chem.202400559. Online ahead of print.PMID: 38411573

Novel meriolin derivatives activate the mitochondrial apoptosis pathway in the presence of antiapoptotic Bcl-2
Schmitt L, Lechtenberg I, Drießen D, Flores-Romero H, Skowron M, Sekeres M, Hoppe J, Krings K, Llewellyn T, Peter C, Stork B, Qin N, Bhatia S, Nettersheim D, Fritz G, García-Sáez A, Müller T and Wesselborg S. Cell Death Discov. 2024 Mar 9;10(1):125.  doi: 10.1038/s41420-024-01901-y

Publications 2022

Cardiac injection of USSC boosts remuscularization of the infarcted heart by shaping the T-cell response.
Ding Z, Tan K, Alter C, Temme S, Bouvain P, Owenier C, Hänsch S, Wesselborg S, Peter C, Weidtkamp-Peters S, Flögel U, Schira-Heinen J, Stühler K, Hesse J, Kögler G, Schrader J. J Mol Cell Cardiol. 2022 Dec 6:S0022-2828(22)00566-1. doi: 10.1016/j.yjmcc.2022.11.006

The mycotoxin viriditoxin induces leukemia- and lymphoma-specific apoptosis by targeting mitochondrial metabolism.
Stuhldreier F, Schmitt L, Lenz T, Hinxlage I, Zimmermann M, Wollnitzke P, Schliehe-Diecks J, Liu Y, Jäger P, Geyh S, Teusch N, Peter C, Bhatia S, Haas R, Levkau B, Reichert A, Stühler K, Proksch P, Stork B, Wesselborg S. Cell Death Dis 2022 Nov 8; volume 13, Article number: 938 (2022); PMID: 36347842  PMCID: PMC9643474  DOI: 10.1038/s41419-022-05356-w

NF90/NFAR (nuclear factors associated with dsRNA) - a new methylation substrate of the PRMT5-WD45-RioK1 complex.
Cox J, Esser LM, Jüdt M, Schmitz K, Reiffert K, Grimmler M, Stork B, Wesselborg S, Peter C. Biol Chem. 2022 Aug 31. doi: 10.1515/hsz-2022-0136. Online ahead of print.PMID: 36040368

Publications 2021

Fin56-induced ferroptosis is supported by autophagy-mediated GPX4 degradation and functions synergistically with mTOR inhibition to kill bladder cancer cells.
Sun Y, Berleth N, Wu W, Schlütermann D, Deitersen J, Stuhldreier F, Berning L, Friedrich A, Akgün S, Mendiburo MJ, Wesselborg S, Conrad M, Berndt C, Stork B. Cell Death Dis. 2021 Oct 29;12(11):1028. doi: 10.1038/s41419-021-04306-2. PMID: 34716292

An essential role of the autophagy activating kinase ULK1 in snRNP biogenesis.
Schmitz K, Cox J, Esser LM, Voss M, Sander K, Löffler A, Hillebrand F, Erkelenz S, Schaal H, Kähne T, Klinker S, Zhang T, Nagel-Steger L, Willbold D, Seggewiß S, Schlütermann D, Stork B, Grimmler M, Wesselborg S, Peter C. Nucleic Acids Res. 2021 Jun 21;49(11):6437-6455. doi: 10.1093/nar/gkab452

40 Years of Research on Polybrominated Diphenyl Ethers (PBDEs)-A Historical Overview and Newest Data of a Promising Anticancer Drug.
Schmitt L, Hinxlage I, Cea P, Gohlke H, Wesselborg S. Molecules. 2021 Feb 13;26(4):995. doi: 10.3390/molecules26040995

Dithiodiketopiperazine derivatives from endophytic fungi Trichoderma harzianum and Epicoccum nigrum.
Harwoko H, Daletos G, Stuhldreier F, Lee J, Wesselborg S, Feldbrügge M, Müller WEG, Kalscheuer R, Ancheeva E, Proksch P. Nat Prod Res. 2021 Jan;35(2):257-265. doi: 10.1080/14786419.2019.1627348. Epub 2019 Jun 18

Publications 2020

Induction of New Lactam Derivatives From the Endophytic Fungus Aplosporella javeedii Through an OSMAC Approach.
Gao Y, Stuhldreier F, Schmitt L, Wesselborg S, Guo Z, Zou K, Mándi A, Kurtán T, Liu Z, Proksch P. Front Microbiol. 2020 Nov 4;11:600983. doi: 10.3389/fmicb.2020.600983. eCollection 2020. PMID: 33250887

Sesterterpenes and macrolide derivatives from the endophytic fungus Aplosporella javeedii.
Gao Y, Stuhldreier F, Schmitt L, Wesselborg S, Wang L, Müller WEG, Kalscheuer R, Guo Z, Zou K, Liu Z, Proksch P.Fitoterapia. 2020 Oct;146:104652. doi: 10.1016/j.fitote.2020.104652. Epub 2020 Jun 6.PMID: 32512149

Carbamoyl-Phosphate Synthase 1 as a Novel Target of Phomoxanthone A, a Bioactive Fungal Metabolite.
Ceccacci S, Deitersen J, Mozzicafreddo M, Morretta E, Proksch P, Wesselborg S, Stork B, Monti MC.Biomolecules. 2020 Jun 2;10(6):846. doi: 10.3390/biom10060846.PMID: 32498414

Publications 2019

First Results from a Screening of 300 Naturally Occurring Compounds: 4,6-dibromo-2-(2',4'-dibromophenoxy)phenol, 4,5,6-tribromo-2-(2',4'-dibromophenoxy)phenol, and 5-epi-nakijinone Q as Substances with the Potential for Anticancer Therapy.
Mayer S, Prechtl M, Liebfried P, Cadeddu RP, Stuhldreier F, Kohl M, Wenzel F, Stork B, Wesselborg S, Proksch P, Germing U, Haas R, Jäger P. Mar Drugs. 2019 Sep 5;17(9):521. doi: 10.3390/md17090521. PMID: 31491907

Azaphilone pigments and macrodiolides from the coprophilous fungus Coniella fragariae.
Yu H, Sperlich J, Höfert SP, Janiak C, Teusch N, Stuhldreier F, Wesselborg S, Wang C, Kassack MU, Dai H, Liu Z, Proksch P. Fitoterapia. 2019 Sep;137:104249. doi: 10.1016/j.fitote.2019.104249. Epub 2019 Jun 25. PMID: 31247219

Novel meriolin derivatives as rapid apoptosis inducers.
Drießen D, Stuhldreier F, Frank A, Stark H, Wesselborg S, Stork B, Müller Th. Bioorg Med Chem. 2019 Aug 1;27(15):3463-3468. doi: 10.1016/j.bmc.2019.06.029. Epub 2019 Jun 19

Publications 2018

Multiple DNA damage-dependent and DNA damage-independent stress responses define the outcome of ATR/Chk1 targeting in medulloblastoma cells.
Krüger K, Geist K, Stuhldreier F, Schumacher L, Blümel L, Remke M, Wesselborg S, Stork B, Klöcker N, Bormann S, Roos WP, Honnen S, Fritz G. Cancer Lett. 2018 Aug 28;430:34-46. doi: 10.1016/j.canlet.2018.05.011. Epub 2018 May 16. PMID: 29753759

The mycotoxin phomoxanthone A disturbs the form and function of the inner mitochondrial membrane.
Böhler P, Stuhldreier F, Anand R, Kondadi AK, Schlütermann D, Berleth N, Deitersen J, Wallot-Hieke N, Wu W, Frank M, Niemann H, Wesbuer E, Barbian A, Luyten T, Parys JB, Weidtkamp-Peters S, Borchardt A, Reichert AS, Peña-Blanco A, García-Sáez AJ, Itskanov S, van der Bliek AM, Proksch P, Wesselborg S, Stork B. Cell Death Dis. 2018 Feb 19;9(3):286. doi: 10.1038/s41419-018-0312-8. PMID: 29459714

Publications 2017

Cyclic Cystine-Bridged Peptides from the Marine Sponge Clathria basilana Induce Apoptosis in Tumor Cells and Depolarize the Bacterial Cytoplasmic Membrane.
Mokhlesi A, Stuhldreier F, Wex KW, Berscheid A, Hartmann R, Rehberg N, Sureechatchaiyan P, Chaidir C, Kassack MU, Kalscheuer R, Brötz-Oesterhelt H, Wesselborg S, Stork B, Daletos G, Proksch P. J Nat Prod. 2017 Nov 22;80(11):2941-2952. doi: 10.1021/acs.jnatprod.7b00477. Epub 2017 Nov 2. PMID: 29094598

Serum α-1 Antitrypsin (AAT) antagonizes intrinsic apoptosis induction in neutrophils from patients with systemic inflammatory response syndrome.
Sarabhai T, Peter C, Bär AK, Windolf J, Relja B, Wesselborg S, Wahlers T, Paunel-Görgülü A. PLoS One. 2017 May 11;12(5):e0177450. doi: 10.1371/journal.pone.0177450. eCollection 2017. PMID: 2849397

Publications 2016

Efficient and safe gene delivery to human corneal endothelium using magnetic nanoparticles.
Czugala M, Mykhaylyk O, Böhler P, Onderka J, Stork B, Wesselborg S, Kruse FE, Plank C, Singer BB, Fuchsluger TA. Nanomedicine (Lond). 2016 Jul;11(14):1787-800. doi: 10.2217/nnm-2016-0144. Epub 2016 Jul 7. PMID: 27388974

Staurosporine resistance in inflammatory neutrophils is associated with the inhibition of caspase- and proteasome-mediated Mcl-1 degradation.
Hornstein T, Lehmann S, Philipp D, Detmer S, Hoffmann M, Peter C, Wesselborg S, Unfried K, Windolf J, Flohé S, Paunel-Görgülü A. J Leukoc Biol. 2016 Jan;99(1):163-74. doi: 10.1189/jlb.3A1114-537RR. Epub 2015 Aug 26. PMID: 26310832

Publications 2015

Autophagy signal transduction by ATG proteins: from hierarchies to networks.
Wesselborg S, Stork B. Cell Mol Life Sci. 2015 Dec;72(24):4721-57. doi: 10.1007/s00018-015-2034-8. Epub 2015 Sep 21. Review. PMID: 26390974

Platelets induce apoptosis via membrane-bound FasL.
Schleicher RI, Reichenbach F, Kraft P, Kumar A, Lescan M, Todt F, Göbel K, Hilgendorf I, Geisler T, Bauer A, Olbrich M, Schaller M, Wesselborg S, O'Reilly L, Meuth SG, Schulze-Osthoff K, Gawaz M, Li X, Kleinschnitz C, Edlich F, Langer HF. Blood. 2015 Sep 17;126(12):1483-93. doi: 10.1182/blood-2013-12-544445. Epub 2015 Jul 31. Erratum in: Blood. 2016 Jan 14;127(2):270. PMID: 26232171

Expression of a ULK1/2 binding-deficient ATG13 variant can partially restore autophagic activity in ATG13-deficient cells.
Hieke N, Löffler AS, Kaizuka T, Berleth N, Böhler P, Drießen S, Stuhldreier F, Friesen O, Assani K, Schmitz K, Peter C, Diedrich B, Dengjel J, Holland P, Simonsen A, Wesselborg S, Mizushima N, Stork B. Autophagy. 2015;11(9):1471-83. doi: 10.1080/15548627.2015.1068488. PMID: 26213203

Deubiquitinase inhibition by WP1130 leads to ULK1 aggregation and blockade of autophagy.
Drießen S, Berleth N, Friesen O, Löffler AS, Böhler P, Hieke N, Stuhldreier F, Peter C, Schink KO, Schultz SW, Stenmark H, Holland P, Simonsen A, Wesselborg S, Stork B. Autophagy. 2015;11(9):1458-70. doi: 10.1080/15548627.2015.1067359. PMID: 26207339

Phomoxanthone A--From Mangrove Forests to Anticancer Therapy.
Frank M, Niemann H, Böhler P, Stork B, Wesselborg S, Lin W, Proksch P. Curr Med Chem. 2015;22(30):3523-32. Review. PMID: 26179997

Pleiotropic effects of spongean alkaloids on mechanisms of cell death, cell cycle progression and DNA damage response (DDR) of acute myeloid leukemia (AML) cells.
Stuhldreier F, Kassel S, Schumacher L, Wesselborg S, Proksch P, Fritz G. Cancer Lett. 2015 May 28;361(1):39-48. doi: 10.1016/j.canlet.2015.02.030. Epub 2015 Feb 16. PMID: 25697484

Publications 2014

ATG13: just a companion, or an executor of the autophagic program
Alers S, Wesselborg S, Stork B. Autophagy. 2014 Jun;10(6):944-56. doi: 10.4161/auto.28987. Review. Erratum in: Autophagy. 2014 Aug;10(8):1481. PMID: 24879146

Callyspongiolide, a cytotoxic macrolide from the marine sponge Callyspongia sp.
Pham CD, Hartmann R, Böhler P, Stork B, Wesselborg S, Lin W, Lai D, Proksch P. Org Lett. 2014 Jan 3;16(1):266-9. doi: 10.1021/ol403241v. Epub 2013 Dec 13. PMID: 24329175

Publications 2013

PDK1 controls upstream PI3K expression and PIP3 generation.
Dieterle AM, Böhler P, Keppeler H, Alers S, Berleth N, Drießen S, Hieke N, Pietkiewicz S, Löffler AS, Peter C, Gray A, Leslie NR, Shinohara H, Kurosaki T, Engelke M, Wienands J, Bonin M, Wesselborg S, Stork B. Oncogene. 2014 Jun 5;33(23):3043-53. doi: 10.1038/onc.2013.266. Epub 2013 Jul 29. PMID: 23893244

Pro-apoptotic and immunostimulatory tetrahydroxanthone dimers from the endophytic fungus Phomopsis longicolla
Rönsberg D, Debbab A, Mándi A, Vasylyeva V, Böhler P, Stork B, Engelke L, Hamacher A, Sawadogo R, Diederich M, Wray V, Lin W, Kassack MU, Janiak C, Scheu S, Wesselborg S, Kurtán T, Aly AH, Proksch P. J Org Chem. 2013 Dec 20;78(24):12409-25. doi: 10.1021/jo402066b. Epub 2013 Dec 11. PMID: 24295452

The p90 ribosomal S6 kinase (RSK) inhibitor BI-D1870 prevents gamma irradiation-induced apoptosis and mediates senescence via RSK- and p53-independent accumulation of p21WAF1/CIP1.
Neise D, Sohn D, Stefanski A, Goto H, Inagaki M, Wesselborg S, Budach W, Stühler K, Jänicke RU. Cell Death Dis. 2013 Oct 17;4:e859. doi: 10.1038/cddis.2013.386. PMID: 24136223

Milk fat globule-EGF factor 8 mediates the enhancement of apoptotic cell clearance by glucocorticoids.
Lauber K, Keppeler H, Munoz LE, Koppe U, Schröder K, Yamaguchi H, Krönke G, Uderhardt S, Wesselborg S, Belka C, Nagata S, Herrmann M. Cell Death Differ. 2013 Sep;20(9):1230-40. doi: 10.1038/cdd.2013.82. Epub 2013 Jul 5. PMID: 23832117

Vemurafenib potently induces endoplasmic reticulum stress-mediated apoptosis in BRAFV600E melanoma cells.
Beck D, Niessner H, Smalley KS, Flaherty K, Paraiso KH, Busch C, Sinnberg T, Vasseur S, Iovanna JL, Drießen S, Stork B, Wesselborg S, Schaller M, Biedermann T, Bauer J, Lasithiotakis K, Weide B, Eberle J, Schittek B, Schadendorf D, Garbe C, Kulms D, Meier F. Sci Signal. 2013 Jan 29;6(260):ra7. doi: 10.1126/scisignal.2003057. PMID: 23362244

Publications 2012

Serum-derived plasminogen is activated by apoptotic cells and promotes their phagocytic clearance.
Rosenwald M, Koppe U, Keppeler H, Sauer G, Hennel R, Ernst A, Blume KE, Peter C, Herrmann M, Belka C, Schulze-Osthoff K, Wesselborg S, Lauber K. J Immunol. 2012 Dec 15;189(12):5722-8. doi: 10.4049/jimmunol.1200922. Epub 2012 Nov 12. PMID: 23150713

Release of lysophospholipid 'find-me' signals during apoptosis requires the ATP-binding cassette transporter A1.
Peter C, Waibel M, Keppeler H, Lehmann R, Xu G, Halama A, Adamski J, Schulze-Osthoff K, Wesselborg S, Lauber K. Autoimmunity. 2012 Dec;45(8):568-73. doi: 10.3109/08916934.2012.719947. Epub 2012 Sep 17. PMID: 22913458

The incredible ULKs.
Alers S, Löffler AS, Wesselborg S, Stork B. Cell Commun Signal. 2012 Mar 13;10(1):7. doi: 10.1186/1478-811X-10-7. PMID: 22413737

Cleavage of annexin A1 by ADAM10 during secondary necrosis generates a monocytic "find-me" signal.
Blume KE, Soeroes S, Keppeler H, Stevanovic S, Kretschmer D, Rautenberg M, Wesselborg S, Lauber K. J Immunol. 2012 Jan 1;188(1):135-45. doi: 10.4049/jimmunol.1004073. Epub 2011 Nov 23. PMID: 22116825

Role of AMPK-mTOR-Ulk1/2 in the regulation of autophagy: cross talk, shortcuts, and feedbacks.
Alers S, Löffler AS, Wesselborg S, Stork B. Mol Cell Biol. 2012 Jan;32(1):2-11. doi: 10.1128/MCB.06159-11. Epub 2011 Oct 24. Review. PMID: 22025673

Publications 2011

Atg13 and FIP200 act independently of Ulk1 and Ulk2 in autophagy induction.
Alers S, Löffler AS, Paasch F, Dieterle AM, Keppeler H, Lauber K, Campbell DG, Fehrenbacher B, Schaller M, Wesselborg S, Stork B. Autophagy. 2011 Dec;7(12):1423-33. PMID: 22024743

Triggering of a novel intrinsic apoptosis pathway by the kinase inhibitor staurosporine: activation of caspase-9 in the absence of Apaf-1.
Manns J, Daubrawa M, Driessen S, Paasch F, Hoffmann N, Löffler A, Lauber K, Dieterle A, Alers S, Iftner T, Schulze-Osthoff K, Stork B, Wesselborg S. FASEB J. 2011 Sep;25(9):3250-61. doi: 10.1096/fj.10-177527. Epub 2011 Jun 9. PMID: 21659556

Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop.
Löffler AS, Alers S, Dieterle AM, Keppeler H, Franz-Wachtel M, Kundu M, Campbell DG, Wesselborg S, Alessi DR, Stork B. Autophagy. 2011 Jul;7(7):696-706. Epub 2011 Jul 1. PMID: 21460634

Dual antitumour effect of 5-azacytidine by inducing a breakdown of resistance-mediating factors and epigenetic modulation.
Venturelli S, Berger A, Weiland T, Zimmermann M, Häcker S, Peter C, Wesselborg S, Königsrainer A, Weiss TS, Gregor M, Fulda S, Lauer UM, Bitzer M. Gut. 2011 Feb;60(2):156-65. doi: 10.1136/gut.2010.208041. Epub 2010 Nov 23. PMID: 21106551

Publications 2010

Apoptosis: opening PANdora's BoX.
Peter C, Wesselborg S, Lauber K. Curr Biol. 2010 Nov 9;20(21):R940-2. doi: 10.1016/j.cub.2010.09.066. Erratum in: Curr Biol. 2011 Jan 11;21(1):96. PMID: 21056838

Autoantibodies to muscarinic acetylcholine receptors found in patients with primary biliary cirrhosis.
Berg CP, Blume K, Lauber K, Gregor M, Berg PA, Wesselborg S, Stein GM. BMC Gastroenterol. 2010 Oct 16;10:120. doi: 10.1186/1471-230X-10-120. PMID: 20950485

Cutaneous papillomavirus E6 proteins must interact with p300 and block p53-mediated apoptosis for cellular immortalization and tumorigenesis.
Muench P, Probst S, Schuetz J, Leiprecht N, Busch M, Wesselborg S, Stubenrauch F, Iftner T. Cancer Res. 2010 Sep 1;70(17):6913-24. doi: 10.1158/0008-5472.CAN-10-1307. Epub 2010 Jul 27. PMID 20663910

Dangerous attraction: phagocyte recruitment and danger signals of apoptotic and necrotic cells.
Peter C, Wesselborg S, Herrmann M, Lauber K. Apoptosis. 2010 Sep;15(9):1007-28. doi: 10.1007/s10495-010-0472-1. Review. PMID: 20157780

AMPK-independent induction of autophagy by cytosolic Ca2+ increase.
Grotemeier A, Alers S, Pfisterer SG, Paasch F, Daubrawa M, Dieterle A, Viollet B, Wesselborg S, Proikas-Cezanne T, Stork B. Cell Signal. 2010 Jun;22(6):914-25. doi: 10.1016/j.cellsig.2010.01.015. Epub 2010 Jan 28. PMID: 20114074

Molecular suicide notes: last call from apoptosing cells.
Peter C, Wesselborg S, Lauber K. J Mol Cell Biol. 2010 Apr;2(2):78-80. doi: 10.1093/jmcb/mjp045. Epub 2009 Dec 11. PMID: 20008330

Publications 2009

Cell surface externalization of annexin A1 as a failsafe mechanism preventing inflammatory responses during secondary necrosis.

Blume KE, Soeroes S, Waibel M, Keppeler H, Wesselborg S, Herrmann M, Schulze-Osthoff K, Lauber K. J Immunol. 2009 Dec 15;183(12):8138-47. doi: 10.4049/jimmunol.0902250. PMID: 20007579

Hepatitis C virus core protein induces apoptosis-like caspase independent cell death.
Berg CP, Schlosser SF, Neukirchen DK, Papadakis C, Gregor M, Wesselborg S, Stein GM. Virol J. 2009 Dec 1;6:213. doi: 10.1186/1743-422X-6-213. PMID: 19951438

Scent of dying cells: the role of attraction signals in the clearance of apoptotic cells and its immunological consequences.
Muñoz LE, Peter C, Herrmann M, Wesselborg S, Lauber K. Autoimmun Rev. 2010 Apr;9(6):425-30. doi: 10.1016/j.autrev.2009.11.016. Epub 2009 Nov 25. Review. PMID: 19932201

Accelerated clearance of Plasmodium-infected erythrocytes in sickle cell trait and annexin-A7 deficiency.
Lang PA, Kasinathan RS, Brand VB, Duranton C, Lang C, Koka S, Shumilina E, Kempe DS, Tanneur V, Akel A, Lang KS, Foller M, Kun JF, Kremsner PG, Wesselborg S, Laufer S, Clemen CS, Herr C, Noegel AA, Wieder T, Gulbins E, Lang F, Huber SM. Cell Physiol Biochem. 2009;24(5-6):415-28. doi: 10.1159/000257529. Epub 2009 Nov 4. PMID: 19910682

Mycoplasma antigens as a possible trigger for the induction of antimitochondrial antibodies in primary biliary cirrhosis.
Berg CP, Kannan TR, Klein R, Gregor M, Baseman JB, Wesselborg S, Lauber K, Stein GM. Liver Int. 2009 Jul;29(6):797-809. doi: 10.1111/j.1478-3231.2008.01942.x. PMID: 19638108

Effects of bacterial N-acyl homoserine lactones on human Jurkat T lymphocytes-OdDHL induces apoptosis via the mitochondrial pathway.
Jacobi CA, Schiffner F, Henkel M, Waibel M, Stork B, Daubrawa M, Eberl L, Gregor M, Wesselborg S. Int J Med Microbiol. 2009 Nov;299(7):509-19. doi: 10.1016/j.ijmm.2009.03.005. Epub 2009 May 22. PMID: 19464950

The Akt inhibitor triciribine sensitizes prostate carcinoma cells to TRAIL-induced apoptosis.
Dieterle A, Orth R, Daubrawa M, Grotemeier A, Alers S, Ullrich S, Lammers R, Wesselborg S, Stork B. Int J Cancer. 2009 Aug 15;125(4):932-41. doi: 10.1002/ijc.24374. PMID: 19422047

Role of BNIP3 in TNF-induced cell death--TNF upregulates BNIP3 expression.
Ghavami S, Eshraghi M, Kadkhoda K, Mutawe MM, Maddika S, Bay GH, Wesselborg S, Halayko AJ, Klonisch T, Los M. Biochim Biophys Acta. 2009 Mar;1793(3):546-60. doi: 10.1016/j.bbamcr.2009.01.002. Epub 2009 Jan 15. PMID: 19321129

Inhibition of Na+/H+ exchanger activity by parvovirus B19 protein NS1.
Lupescu A, Geiger C, Zahir N, Aberle S, Lang PA, Kramer S, Wesselborg S, Kandolf R, Foller M, Lang F, Bock CT. Cell Physiol Biochem. 2009;23(1-3):211-20. doi: 10.1159/000204110. Epub 2009 Feb 18. PMID: 19255516

Unscheduled Akt-triggered activation of cyclin-dependent kinase 2 as a key effector mechanism of apoptin's anticancer toxicity.
Maddika S, Panigrahi S, Wiechec E, Wesselborg S, Fischer U, Schulze-Osthoff K, Los M. Mol Cell Biol. 2009 Mar;29(5):1235-48. doi: 10.1128/MCB.00668-08. Epub 2008 Dec 22. PMID: 19103742

Publications 2008

Cancer stem cell markers in common cancers - therapeutic implications.
Klonisch T, Wiechec E, Hombach-Klonisch S, Ande SR, Wesselborg S, Schulze-Osthoff K, Los M. Trends Mol Med. 2008 Oct;14(10):450-60. doi: 10.1016/j.molmed.2008.08.003. Epub 2008 Sep 3. Review. PMID: 18775674

Regulation of calcineurin activity in insulin-secreting cells: stimulation by Hsp90 during glucocorticoid-induced apoptosis
Ranta F, Düfer M, Stork B, Wesselborg S, Drews G, Häring HU, Lang F, Ullrich S. Cell Signal. 2008 Oct;20(10):1780-6. doi: 10.1016/j.cellsig.2008.06.003. Epub 2008 Jun 18. PMID: 18611438

Akt-mediated phosphorylation of CDK2 regulates its dual role in cell cycle progression and apoptosis.
Maddika S, Ande SR, Wiechec E, Hansen LL, Wesselborg S, Los M. J Cell Sci. 2008 Apr 1;121(Pt 7):979-88. doi: 10.1242/jcs.009530. PMID: 18354084

S100A8/A9 at low concentration promotes tumor cell growth via RAGE ligation and MAP kinase-dependent pathway.
Ghavami S, Rashedi I, Dattilo BM, Eshraghi M, Chazin WJ, Hashemi M, Wesselborg S, Kerkhoff C, Los M. J Leukoc Biol. 2008 Jun;83(6):1484-92. doi: 10.1189/jlb.0607397. Epub 2008 Mar 13. PMID: 18339893

Migration to apoptotic "find-me" signals is mediated via the phagocyte receptor G2A.
Peter C, Waibel M, Radu CG, Yang LV, Witte ON, Schulze-Osthoff K, Wesselborg S, Lauber K. J Biol Chem. 2008 Feb 29;283(9):5296-305. Epub 2007 Dec 18. PMID: 18089568

Apoptosis-associated antigens recognized by autoantibodies in patients with the autoimmune liver disease primary biliary cirrhosis.
Berg CP, Stein GM, Keppeler H, Gregor M, Wesselborg S, Lauber K. Apoptosis. 2008 Jan;13(1):63-75. PMID: 18060504

Interaction with PI3-kinase contributes to the cytotoxic activity of apoptin.
Maddika S, Wiechec E, Ande SR, Poon IK, Fischer U, Wesselborg S, Jans DA, Schulze-Osthoff K, Los M. Oncogene. 2008 May 8;27(21):3060-5. Epub 2007 Dec 3. PMID: 18059340

Myrtucommulone from Myrtus communis induces apoptosis in cancer cells via the mitochondrial pathway involving caspase-9.
Tretiakova I, Blaesius D, Maxia L, Wesselborg S, Schulze-Osthoff K, Cinatl J Jr, Michaelis M, Werz O. Apoptosis. 2008 Jan;13(1):119-31. PMID: 17955373

Publications 2007

Interferon-gamma and tumor necrosis factor-alpha sensitize primarily resistant human endometrial stromal cells to Fas-mediated apoptosis.
Fluhr H, Krenzer S, Stein GM, Stork B, Deperschmidt M, Wallwiener D, Wesselborg S, Zygmunt M, Licht P. J Cell Sci. 2007 Dec 1;120(Pt 23):4126-33. Epub 2007 Nov 14. PMID: 18003704

Catalytically active Yersinia outer protein P induces cleavage of RIP and caspase-8 at the level of the DISC independently of death receptors in dendritic cells.
Gröbner S, Adkins I, Schulz S, Richter K, Borgmann S, Wesselborg S, Ruckdeschel K, Micheau O, Autenrieth IB. Apoptosis. 2007 Oct;12(10):1813-25. PMID: 17624595

Attraction of phagocytes by apoptotic cells is mediated by lysophosphatidylcholine.
Mueller RB, Sheriff A, Gaipl US, Wesselborg S, Lauber K. Autoimmunity. 2007 Jun;40(4):342-4. Review. PMID: 17516225

Platelets recruit human dendritic cells via Mac-1/JAM-C interaction and modulate dendritic cell function in vitro.
Langer HF, Daub K, Braun G, Schönberger T, May AE, Schaller M, Stein GM, Stellos K, Bueltmann A, Siegel-Axel D, Wendel HP, Aebert H, Roecken M, Seizer P, Santoso S, Wesselborg S, Brossart P, Gawaz M. Arterioscler Thromb Vasc Biol. 2007 Jun;27(6):1463-70. Epub 2007 Mar 22. PMID: 17379836

Mitochondria are not required for death receptor-mediated cytosolic acidification during apoptosis.
Waibel M, Kramer S, Lauber K, Lupescu A, Manns J, Schulze-Osthoff K, Lang F, Wesselborg S. Apoptosis. 2007 Mar;12(3):623-30. Epub 2006 Dec 29. PMID: 17195091

Absence of Toll-like receptor 4 signaling results in delayed Yersinia enterocolitica YopP-induced cell death of dendritic cells.
Gröbner S, Schulz S, Soldanova I, Gunst DS, Waibel M, Wesselborg S, Borgmann S, Autenrieth IB. Infect Immun. 2007 Jan;75(1):512-7. Epub 2006 Oct 30. PMID: 17074859

Publications 2006

Yersinia YopP-induced apoptotic cell death in murine dendritic cells is partially independent from action of caspases and exhibits necrosis-like features.
Gröbner S, Autenrieth SE, Soldanova I, Gunst DS, Schaller M, Bohn E, Müller S, Leverkus M, Wesselborg S, Autenrieth IB, Borgmann S. Apoptosis. 2006 Nov;11(11):1959-68. PMID: 17036200

Demonstration of PDC-E1 subunits as major antigens in the complement-fixing fraction M4 and re-evaluation of PDC-E1-specific antibodies in PBC patients.
Berg CP, Stein GM, Klein R, Pascu M, Berg T, Kammer W, Priemer M, Nordheim A, Schulze-Osthoff K, Gregor M, Wesselborg S, Berg PA. Liver Int. 2006 Sep;26(7):846-55. PMID: 16911468

Caspase-3-dependent activation of calcium-independent phospholipase A2 enhances cell migration in non-apoptotic ovarian cancer cells.
Zhao X, Wang D, Zhao Z, Xiao Y, Sengupta S, Xiao Y, Zhang R, Lauber K, Wesselborg S, Feng L, Rose TM, Shen Y, Zhang J, Prestwich G, Xu Y. J Biol Chem. 2006 Sep 29;281(39):29357-68. Epub 2006 Aug 1. PMID: 16882668

Cell-cycle progression and response of germ cell tumors to cisplatin in vitro.
Mueller S, Schittenhelm M, Honecker F, Malenke E, Lauber K, Wesselborg S, Hartmann JT, Bokemeyer C, Mayer F. Int J Oncol. 2006 Aug;29(2):471-9. PMID: 16820891

Publications 2005

Cooperative cytotoxicity of proteasome inhibitors and tumor necrosis factor-related apoptosis-inducing ligand in chemoresistant Bcl-2-overexpressing cells.
Nencioni A, Wille L, Dal Bello G, Boy D, Cirmena G, Wesselborg S, Belka C, Brossart P, Patrone F, Ballestrero A. Clin Cancer Res. 2005 Jun 1;11(11):4259-65. PMID: 15930365

STAT3 is essential for Hodgkin lymphoma cell proliferation and is a target of tyrphostin AG17 which confers sensitization for apoptosis.
Holtick U, Vockerodt M, Pinkert D, Schoof N, Stürzenhofecker B, Kussebi N, Lauber K, Wesselborg S, Löffler D, Horn F, Trümper L, Kube D. Leukemia. 2005 Jun;19(6):936-44. PMID: 15912144

Prostaglandin D2 induces programmed cell death in Trypanosoma brucei bloodstream form.
Figarella K, Rawer M, Uzcategui NL, Kubata BK, Lauber K, Madeo F, Wesselborg S, Duszenko M. Cell Death Differ. 2005 Apr;12(4):335-46. PMID: 15678148

Bartonella henselae inhibits apoptosis in Mono Mac 6 cells.
Kempf VA, Schairer A, Neumann D, Grassl GA, Lauber K, Lebiedziejewski M, Schaller M, Kyme P, Wesselborg S, Autenrieth IB. Cell Microbiol. 2005 Jan;7(1):91-104. PMID: 15617526

Evidence for a protective role of Mcl-1 in proteasome inhibitor-induced apoptosis.
Nencioni A, Hua F, Dillon CP, Yokoo R, Scheiermann C, Cardone MH, Barbieri E, Rocco I, Garuti A, Wesselborg S, Belka C, Brossart P, Patrone F, Ballestrero A. Blood. 2005 Apr 15;105(8):3255-62. Epub 2004 Dec 21. PMID: 15613543

Type I and type II reactions in TRAIL-induced apoptosis -- results from dose-response studies.
Rudner J, Jendrossek V, Lauber K, Daniel PT, Wesselborg S, Belka C. Oncogene. 2005 Jan 6;24(1):130-40. PMID: 15531922

Ets1 is an effector of protein kinase Calpha in cancer cells
Vetter M, Blumenthal SG, Lindemann RK, Manns J, Wesselborg S, Thomssen C, Dittmer J. Oncogene. 2005 Jan 20;24(4):650-61. Erratum in: Oncogene. 2005 Jun 16;24(26):4319.  PMID: 15531915

Publication 2004

Clearance of apoptotic cells: getting rid of the corpses.
Lauber K, Blumenthal SG, Waibel M, Wesselborg S. Mol Cell. 2004 May 7;14(3):277-87. Review. PMID: 15125832

Tumor necrosis factor-related apoptosis-inducing ligand cooperates with anticancer drugs to overcome chemoresistance in antiapoptotic Bcl-2 family members expressing jurkat cells.
Ballestrero A, Nencioni A, Boy D, Rocco I, Garuti A, Mela GS, Van Parijs L, Brossart P, Wesselborg S, Patrone F. Clin Cancer Res. 2004 Feb 15;10(4):1463-70. PMID: 14977850

Cyclopentenone prostaglandins induce lymphocyte apoptosis by activating the mitochondrial apoptosis pathway independent of external death receptor signaling.
Nencioni A, Lauber K, Grünebach F, Van Parijs L, Denzlinger C, Wesselborg S, Brossart P. J Immunol. 2003 Nov 15;171(10):5148-56. PMID: 14607914

Role of peroxisome proliferator-activated receptor gamma and its ligands in the control of immune responses.
Nencioni A, Wesselborg S, Brossart P. Crit Rev Immunol. 2003;23(1-2):1-13. Review. PMID: 12906257

Apoptotic cells induce migration of phagocytes via caspase-3-mediated release of a lipid attraction signal.
Lauber K, Bohn E, Kröber SM, Xiao YJ, Blumenthal SG, Lindemann RK, Marini P, Wiedig C, Zobywalski A, Baksh S, Xu Y, Autenrieth IB, Schulze-Osthoff K, Belka C, Stuhler G, Wesselborg S. Cell. 2003 Jun 13;113(6):717-30

Ribavirin and alpha interferon enhance death receptor-mediated apoptosis and caspase activation in human hepatoma cells
Schlosser SF, Schuler M, Berg CP, Lauber K, Schulze-Osthoff K, Schmahl FW, Wesselborg S. Antimicrob Agents Chemother. 2003 Jun;47(6):1912-21. PMID: 12760867

Tributyltin (TBT) induces ultra-rapid caspase activation independent of apoptosome formation in human platelets.
Berg CP, Rothbart A, Lauber K, Stein GM, Engels IH, Belka C, Jänicke RU, Schulze-Osthoff K, Wesselborg S. Oncogene. 2003 Feb 6;22(5):775-80. PMID: 12569371

The tyrosine kinase Lck is involved in regulation of mitochondrial apoptosis pathways.
Belka C, Gruber C, Jendrossek V, Wesselborg S, Budach W. Oncogene. 2003 Jan 16;22(2):176-85. PMID: 12527887

Legionella pneumophila induces apoptosis via the mitochondrial death pathway.
Neumeister B, Faigle M, Lauber K, Northoff H, Wesselborg S. Microbiology. 2002 Nov;148(Pt 11):3639-50. PMID: 12427954

Cyclopentenone prostaglandins induce caspase activation and apoptosis in dendritic cells by a PPAR-gamma-independent mechanism: regulation by inflammatory and T cell-derived stimuli.
Nencioni A, Lauber K, Grünebach F, Brugger W, Denzlinger C, Wesselborg S, Brossart P. Exp Hematol. 2002 Sep;30(9):1020-8. PMID: 12225793

A caspase-related protease regulates apoptosis in yeast.
Madeo F, Herker E, Maldener C, Wissing S, Lächelt S, Herlan M, Fehr M, Lauber K, Sigrist SJ, Wesselborg S, Fröhlich KU. Mol Cell. 2002 Apr;9(4):911-7. PMID: 11983181

Publications 2001

Human mature red blood cells express caspase-3 and caspase-8, but are devoid of mitochondrial regulators of apoptosis.
Berg CP, Engels IH, Rothbart A, Lauber K, Renz A, Schlosser SF, Schulze-Osthoff K, Wesselborg S. Cell Death Differ. 2001 Dec;8(12):1197-206. PMID: 11753567

Wild-type, mitochondrial and ER-restricted Bcl-2 inhibit DNA damage-induced apoptosis but do not affect death receptor-induced apoptosis.
Rudner J, Lepple-Wienhues A, Budach W, Berschauer J, Friedrich B, Wesselborg S, Schulze-Osthoff K, Belka C. J Cell Sci. 2001 Dec;114(Pt 23):4161-72. PMID: 11739649

The adapter protein apoptotic protease-activating factor-1 (Apaf-1) is proteolytically processed during apoptosis.
Lauber K, Appel HA, Schlosser SF, Gregor M, Schulze-Osthoff K, Wesselborg S. J Biol Chem. 2001 Aug 10;276(32):29772-81. Epub 2001 May 31. PMID: 11387322

Staurosporine and conventional anticancer drugs induce overlapping, yet distinct pathways of apoptosis and caspase activation.
Stepczynska A, Lauber K, Engels IH, Janssen O, Kabelitz D, Wesselborg S, Schulze-Osthoff K. Oncogene. 2001 Mar 8;20(10):1193-202. PMID: 11313863

Effects of nebivolol on proliferation and apoptosis of human coronary artery smooth muscle and endothelial cells.
Brehm BR, Wolf SC, Bertsch D, Klaussner M, Wesselborg S, Schüler S, Schulze-Osthoff K. Cardiovasc Res. 2001 Feb 1;49(2):430-9. PMID: 11164853

Prevention of human smooth muscle cell proliferation without induction of apoptosis by the topoisomerase I inhibitor topotecan.
Brehm BR, Bock C, Wesselborg S, Pfeiffer S, Schüler S, Schulze-Osthoff K. Biochem Pharmacol. 2001 Jan 1;61(1):119-27. PMID: 11137716

Publications 2000

The serine phosphatases PP1 and PP2A associate with and activate the actin-binding protein cofilin in human T lymphocytes.
Ambach A, Saunus J, Konstandin M, Wesselborg S, Meuer SC, Samstag Y. Eur J Immunol. 2000 Dec;30(12):3422-31. PMID: 11093160

Caspase-8/FLICE functions as an executioner caspase in anticancer drug-induced apoptosis.
Engels IH, Stepczynska A, Stroh C, Lauber K, Berg C, Schwenzer R, Wajant H, Jänicke RU, Porter AG, Belka C, Gregor M, Schulze-Osthoff K, Wesselborg S. Oncogene. 2000 Sep 21;19(40):4563-73. PMID: 11030145

Differential role of caspase-8 and BID activation during radiation- and CD95-induced apoptosis.
Belka C, Rudner J, Wesselborg S, Stepczynska A, Marini P, Lepple-Wienhues A, Faltin H, Bamberg M, Budach W, Schulze-Osthoff K. Oncogene. 2000 Feb 24;19(9):1181-90. PMID: 10713706

Publications 1999

The role of caspases in development, immunity, and apoptotic signal transduction: lessons from knockout mice.
Los M, Wesselborg S, Schulze-Osthoff K. Immunity. 1999 Jun;10(6):629-39. Review. No abstract available. PMID: 10403638

Mistletoe lectin activates caspase-8/FLICE independently of death receptor signaling and enhances anticancer drug-induced apoptosis.
Bantel H, Engels IH, Voelter W, Schulze-Osthoff K, Wesselborg S. Cancer Res. 1999 May 1;59(9):2083-90. PMID: 10232592

P2Z purinoreceptor ligation induces activation of caspases with distinct roles in apoptotic and necrotic alterations of cell death.
Ferrari D, Los M, Bauer MK, Vandenabeele P, Wesselborg S, Schulze-Osthoff K. FEBS Lett. 1999 Mar 19;447(1):71-5. PMID: 10218585

Anticancer drugs induce caspase-8/FLICE activation and apoptosis in the absence of CD95 receptor/ligand interaction.
Wesselborg S, Engels IH, Rossmann E, Los M, Schulze-Osthoff K.Blood. 1999 May 1;93(9):3053-63. PMID: 10216102

Publications 1998

Differential regulation and ATP requirement for caspase-8 and caspase-3 activation during CD95- and anticancer drug-induced apoptosis.
Ferrari D, Stepczynska A, Los M, Wesselborg S, Schulze-Osthoff K. J Exp Med. 1998 Sep 7;188(5):979-84. PMID: 9730899

Apoptosis signaling by death receptors.
Schulze-Osthoff K, Ferrari D, Los M, Wesselborg S, Peter ME. Eur J Biochem. 1998 Jun 15;254(3):439-59. Review. PMID: 9688254

Role of reactive oxygen intermediates in activation-induced CD95 (APO-1/Fas) ligand expression.
Bauer MK, Vogt M, Los M, Siegel J, Wesselborg S, Schulze-Osthoff K. J Biol Chem. 1998 Apr 3;273(14):8048-55. PMID: 952590

Publications 1997

Extracellular ATP activates transcription factor NF-kappaB through the P2Z purinoreceptor by selectively targeting NF-kappaB p65.
Ferrari D, Wesselborg S, Bauer MK, Schulze-Osthoff K. J Cell Biol. 1997 Dec 29;139(7):1635-43. PMID: 9412459

Regulation of NF-kappa B activation by MAP kinase cascades.
Schulze-Osthoff K, Ferrari D, Riehemann K, Wesselborg S. Immunobiology. 1997 Dec;198(1-3):35-49. Review. PMID: 9442376

Activation of transcription factor NF-kappaB and p38 mitogen-activated protein kinase is mediated by distinct and separate stress effector pathways.
Wesselborg S, Bauer MK, Vogt M, Schmitz ML, Schulze-Osthoff K. J Biol Chem. 1997 May 9;272(19):12422-9. PMID: 9139689

The Caenorhabditis elegans death protein Ced-4 contains a motif with similarity to the mammalian 'death effector domain'.
Bauer MK, Wesselborg S, Schulze-Osthoff K. FEBS Lett. 1997 Feb 3;402(2-3):256-8. PMID: 9037206

Oxidative stress and signal transduction.
Schulze-Osthoff K, Bauer MK, Vogt M, Wesselborg S. Int J Vitam Nutr Res. 1997;67(5):336-42. Review. PMID: 9350475

Publications 1996

Competitive inhibition of calcineurin phosphatase activity by its autoinhibitory domain.
Sagoo JK, Fruman DA, Wesselborg S, Walsh CT, Bierer BE. Biochem J. 1996 Dec 15;320 ( Pt 3):879-84. PMID: 9003375

[Oxygen radicals as second messengers of gene expression].
Schulze-Osthoff K, Wesselborg S. Dtsch Med Wochenschr. 1996 Oct 18;121(42):1301-2. German. No abstract available. PMID: 8964205

Identification of a physical interaction between calcineurin and nuclear factor of activated T cells (NFATp).
Wesselborg S, Fruman DA, Sagoo JK, Bierer BE, Burakoff SJ. J Biol Chem. 1996 Jan 19;271(3):1274-7. PMID: 8576111

Publications 1994

Costimulatory signals for human T-cell activation induce nuclear translocation of pp19/cofilin.
Samstag Y, Eckerskorn C, Wesselborg S, Henning S, Wallich R, Meuer SC. Proc Natl Acad Sci U S A. 1994 May 10;91(10):4494-8. PMID: 8183936

Triggering via the alternative CD2 pathway induces apoptosis in activated human T lymphocytes.
Wesselborg S, Prüfer U, Wild M, Schraven B, Meuer SC, Kabelitz D. Eur J Immunol. 1993 Oct;23(10):2707-10. PMID: 7691614

Induction of activation-driven death (apoptosis) in activated but not resting peripheral blood T cells.
Wesselborg S, Janssen O, Kabelitz D. J Immunol. 1993 May 15;150(10):4338-45. PMID: 8482839

Activation-driven death of human T cell clones: time course kinetics of the induction of cell shrinkage, DNA fragmentation, and cell death.
Wesselborg S, Kabelitz D. Cell Immunol. 1993 Apr 15;148(1):234-41. PMID: 8098667

Publications 1992

Life and death of a superantigen-reactive human CD4+ T cell clone: staphylococcal enterotoxins induce death by apoptosis but simultaneously trigger a proliferative response in the presence of HLA-DR+ antigen-presenting cells.
Kabelitz D, Wesselborg S. Int Immunol. 1992 Dec;4(12):1381-8. PMID: 1363055

Immunosuppression by OKT3--induction of programmed cell death (apoptosis) as a possible mechanism of action.
Janssen O, Wesselborg S, Kabelitz D. Transplantation. 1992 Jan;53(1):233-4. No abstract available.  PMID: 1531094

Publications 1991

The primary response of human gamma/delta + T cells to Mycobacterium tuberculosis is restricted to V gamma 9-bearing cells.
Kabelitz D, Bender A, Prospero T, Wesselborg S, Janssen O, Pechhold K. J Exp Med. 1991 Jun 1;173(6):1331-8. PMID: 182782

Activation and activation-driven death of human gamma/delta T cells.
Kabelitz D, Pechhold K, Bender A, Wesselborg S, Wesch D, Friese K, Janssen O. Immunol Rev. 1991 Apr;120:71-88. Review. PMID: 1677929

Selective activation of gamma/delta + T cell clones by single anti-CD2 antibodies.
Wesselborg S, Janssen O, Pechhold K, Kabelitz D. J Exp Med. 1991 Feb 1;173(2):297-304. PMID: 1703204

Activation and deactivation of cloned gamma/delta T cells.
Kabelitz D, Wesselborg S, Pechold K, Janssen O. Curr Top Microbiol Immunol. 1991;173:197-202. No abstract available. PMID: 1833143

T cell receptor/CD3-signaling induces death by apoptosis in human T cell receptor gamma delta + T cells.
Janssen O, Wesselborg S, Heckl-Ostreicher B, Pechhold K, Bender A, Schondelmaier S, Moldenhauer G, Kabelitz D. J Immunol. 1991 Jan 1;146(1):35-9. PMID: 1824593