Publikationen S. Wesselborg

Publications 2025

Antineoplastic therapy affects the in vitro phenotype and functionality of healthy human bone marrow-derived mesenchymal stromal cells.
Scherer B, Bogun L, Koch A, Jäger P, Maus U, Schmitt L, Krings KS, Wesselborg S, Haas R, Schroeder T, Geyh S. Arch Toxicol. 2025 Jan;99(1):393-406. doi: 10.1007/s00204-024-03898-w. Epub 2024 Nov 12.PMID: 39531065

Publications 2024

Novel 4-alkoxy Meriolin Congeners Potently Induce Apoptosis in Leukemia and Lymphoma Cells.
Krings KS, Wassenberg TR, Cea-Medina P, Schmitt L, Lechtenberg I, Llewellyn TR, Qin N, Gohlke H, Wesselborg S, Müller TJJ. Molecules. 2024 Dec 23;29(24):6050. doi: 10.3390/molecules29246050. PMID: 39770138

Evaluation of Genotoxic Effects of N-Methyl-N-Nitroso-Urea and Etoposide on the Differentiation Potential of MSCs from Umbilical Cord Blood and Bone Marrow.
Ouzin M, Wesselborg S, Fritz G, Kogler G. Cells. 2024 Dec 23;13(24):2134. doi: 10.3390/cells13242134.PMID: 39768222

Targeting mitochondrial metabolism by the mitotoxin bromoxib in leukemia and lymphoma cells
Schmitt L, Krings KS, Wolsing A, Buque X, Zimmermann M, Flores-Romero H, Lenz T, Lechtenberg I, Peter C, Stork B, Teusch N, Proksch P, Stühler K, García-Sáez A, Reichert A, Aspichueta P, Bhatia S and Wesselborg S. Cell Commun Signal 2024 Nov 12;22(1):541. doi: 10.1186/s12964-024-01913-2.

Novel meriolin derivatives potently inhibit cell cycle progression and transcription in leukemia and lymphoma cells via inhibition of cyclin-dependent kinases (CDKs)
Schmitt L, Hoppe J, Cea-Medina P, Bruch P-M, Krings KS, Lechtenberg I, Drießen D, Peter Ch, Bhatia S, Dietrich S, Stork B, Fritz G, Gohlke H, Müller ThJJ, Wesselborg S. Cell Death Discov. 2024 Jun 11; 10(1):279. PMID: 38862521, doi: 10.1038/s41420-024-02056-6

From the Total Synthesis of Semi-Viriditoxin, Semi-Viriditoxic Acid and Dimeric Naphthopyranones to their Biological Activities in Burkitt B Cell Lymphoma.
Weber F, Weber A, Schmitt L, Lechtenberg I, Greb J, Henßen B, Wesselborg S, Pietruszka J. Chemistry. 2024 Feb 27; e202400559. doi: 10.1002/chem.202400559. Online ahead of print.PMID: 38411573

Novel meriolin derivatives activate the mitochondrial apoptosis pathway in the presence of antiapoptotic Bcl-2
Schmitt L, Lechtenberg I, Drießen D, Flores-Romero H, Skowron M, Sekeres M, Hoppe J, Krings K, Llewellyn T, Peter C, Stork B, Qin N, Bhatia S, Nettersheim D, Fritz G, García-Sáez A, Müller T and Wesselborg S. Cell Death Discov. 2024 Mar 9;10(1):125.  doi: 10.1038/s41420-024-01901-y

Publications 2023

The Impact of p70S6 Kinase-Dependent Phosphorylation of Gemin2 in UsnRNP Biogenesis.
Esser LM, Li Q, Jüdt M, Kähne T, Stork B, Grimmler M, Wesselborg S, Peter C. Int J Mol Sci. 2023 Oct 25;24(21):15552. doi: 10.3390/ijms242115552.PMID: 37958537

Phosphorylation of pICln by the autophagy activating kinase ULK1 regulates snRNP biogenesis and splice activity of the cell.
Esser LM, Schmitz K, Hillebrand F, Erkelenz S, Schaal H, Stork B, Grimmler M, Wesselborg S, Peter C. Comput Struct Biotechnol J. 2023 Mar 16;21:2100-2109. doi: 10.1016/j.csbj.2023.03.015. eCollection 2023.PMID: 36968021

Publications 2022

Cardiac injection of USSC boosts remuscularization of the infarcted heart by shaping the T-cell response.
Ding Z, Tan K, Alter C, Temme S, Bouvain P, Owenier C, Hänsch S, Wesselborg S, Peter C, Weidtkamp-Peters S, Flögel U, Schira-Heinen J, Stühler K, Hesse J, Kögler G, Schrader J. J Mol Cell Cardiol. 2022 Dec 6:S0022-2828(22)00566-1. doi: 10.1016/j.yjmcc.2022.11.006

The mycotoxin viriditoxin induces leukemia- and lymphoma-specific apoptosis by targeting mitochondrial metabolism.
Stuhldreier F, Schmitt L, Lenz T, Hinxlage I, Zimmermann M, Wollnitzke P, Schliehe-Diecks J, Liu Y, Jäger P, Geyh S, Teusch N, Peter C, Bhatia S, Haas R, Levkau B, Reichert A, Stühler K, Proksch P, Stork B, Wesselborg S. Cell Death Dis 2022 Nov 8; volume 13, Article number: 938 (2022); PMID: 36347842  PMCID: PMC9643474  DOI: 10.1038/s41419-022-05356-w

Heterologously secreted MbxA from Moraxella bovis induces a membrane blebbing response of the human host cell.
Erenburg IN, Hänsch S, Chacko FM, Hamacher A, Wintgens S, Stuhldreier F, Poschmann G, Spitz O, Stühler K, Wesselborg S, Hegemann JH, Smits SHJ, Weidtkamp-Peters S, Schmitt L. Sci Rep. 2022 Oct 24;12(1):17825. doi: 10.1038/s41598-022-22480-x.PMID: 362807

NF90/NFAR (nuclear factors associated with dsRNA) - a new methylation substrate of the PRMT5-WD45-RioK1 complex.
Cox J, Esser LM, Jüdt M, Schmitz K, Reiffert K, Grimmler M, Stork B, Wesselborg S, Peter C. Biol Chem. 2022 Aug 31. doi: 10.1515/hsz-2022-0136. Online ahead of print.PMID: 36040368

Publications 2021

Fin56-induced ferroptosis is supported by autophagy-mediated GPX4 degradation and functions synergistically with mTOR inhibition to kill bladder cancer cells.
Sun Y, Berleth N, Wu W, Schlütermann D, Deitersen J, Stuhldreier F, Berning L, Friedrich A, Akgün S, Mendiburo MJ, Wesselborg S, Conrad M, Berndt C, Stork B. Cell Death Dis. 2021 Oct 29;12(11):1028. doi: 10.1038/s41419-021-04306-2. PMID: 34716292

An essential role of the autophagy activating kinase ULK1 in snRNP biogenesis.
Schmitz K, Cox J, Esser LM, Voss M, Sander K, Löffler A, Hillebrand F, Erkelenz S, Schaal H, Kähne T, Klinker S, Zhang T, Nagel-Steger L, Willbold D, Seggewiß S, Schlütermann D, Stork B, Grimmler M, Wesselborg S, Peter C. Nucleic Acids Res. 2021 Jun 21;49(11):6437-6455. doi: 10.1093/nar/gkab452

40 Years of Research on Polybrominated Diphenyl Ethers (PBDEs)-A Historical Overview and Newest Data of a Promising Anticancer Drug.
Schmitt L, Hinxlage I, Cea P, Gohlke H, Wesselborg S. Molecules. 2021 Feb 13;26(4):995. doi: 10.3390/molecules26040995

Dithiodiketopiperazine derivatives from endophytic fungi Trichoderma harzianum and Epicoccum nigrum.
Harwoko H, Daletos G, Stuhldreier F, Lee J, Wesselborg S, Feldbrügge M, Müller WEG, Kalscheuer R, Ancheeva E, Proksch P. Nat Prod Res. 2021 Jan;35(2):257-265. doi: 10.1080/14786419.2019.1627348. Epub 2019 Jun 18

Publications 2020

Induction of New Lactam Derivatives From the Endophytic Fungus Aplosporella javeedii Through an OSMAC Approach.
Gao Y, Stuhldreier F, Schmitt L, Wesselborg S, Guo Z, Zou K, Mándi A, Kurtán T, Liu Z, Proksch P. Front Microbiol. 2020 Nov 4;11:600983. doi: 10.3389/fmicb.2020.600983. eCollection 2020. PMID: 33250887

Sesterterpenes and macrolide derivatives from the endophytic fungus Aplosporella javeedii.
Gao Y, Stuhldreier F, Schmitt L, Wesselborg S, Wang L, Müller WEG, Kalscheuer R, Guo Z, Zou K, Liu Z, Proksch P.Fitoterapia. 2020 Oct;146:104652. doi: 10.1016/j.fitote.2020.104652. Epub 2020 Jun 6.PMID: 32512149

Carbamoyl-Phosphate Synthase 1 as a Novel Target of Phomoxanthone A, a Bioactive Fungal Metabolite.
Ceccacci S, Deitersen J, Mozzicafreddo M, Morretta E, Proksch P, Wesselborg S, Stork B, Monti MC.Biomolecules. 2020 Jun 2;10(6):846. doi: 10.3390/biom10060846.PMID: 32498414

Publications 2019

First Results from a Screening of 300 Naturally Occurring Compounds: 4,6-dibromo-2-(2',4'-dibromophenoxy)phenol, 4,5,6-tribromo-2-(2',4'-dibromophenoxy)phenol, and 5-epi-nakijinone Q as Substances with the Potential for Anticancer Therapy.
Mayer S, Prechtl M, Liebfried P, Cadeddu RP, Stuhldreier F, Kohl M, Wenzel F, Stork B, Wesselborg S, Proksch P, Germing U, Haas R, Jäger P. Mar Drugs. 2019 Sep 5;17(9):521. doi: 10.3390/md17090521. PMID: 31491907

Azaphilone pigments and macrodiolides from the coprophilous fungus Coniella fragariae.
Yu H, Sperlich J, Höfert SP, Janiak C, Teusch N, Stuhldreier F, Wesselborg S, Wang C, Kassack MU, Dai H, Liu Z, Proksch P. Fitoterapia. 2019 Sep;137:104249. doi: 10.1016/j.fitote.2019.104249. Epub 2019 Jun 25. PMID: 31247219

Novel meriolin derivatives as rapid apoptosis inducers.
Drießen D, Stuhldreier F, Frank A, Stark H, Wesselborg S, Stork B, Müller Th. Bioorg Med Chem. 2019 Aug 1;27(15):3463-3468. doi: 10.1016/j.bmc.2019.06.029. Epub 2019 Jun 19

Publications 2018

Multiple DNA damage-dependent and DNA damage-independent stress responses define the outcome of ATR/Chk1 targeting in medulloblastoma cells.
Krüger K, Geist K, Stuhldreier F, Schumacher L, Blümel L, Remke M, Wesselborg S, Stork B, Klöcker N, Bormann S, Roos WP, Honnen S, Fritz G. Cancer Lett. 2018 Aug 28;430:34-46. doi: 10.1016/j.canlet.2018.05.011. Epub 2018 May 16. PMID: 29753759

The mycotoxin phomoxanthone A disturbs the form and function of the inner mitochondrial membrane.
Böhler P, Stuhldreier F, Anand R, Kondadi AK, Schlütermann D, Berleth N, Deitersen J, Wallot-Hieke N, Wu W, Frank M, Niemann H, Wesbuer E, Barbian A, Luyten T, Parys JB, Weidtkamp-Peters S, Borchardt A, Reichert AS, Peña-Blanco A, García-Sáez AJ, Itskanov S, van der Bliek AM, Proksch P, Wesselborg S, Stork B. Cell Death Dis. 2018 Feb 19;9(3):286. doi: 10.1038/s41419-018-0312-8. PMID: 29459714

Publications 2017

Cyclic Cystine-Bridged Peptides from the Marine Sponge Clathria basilana Induce Apoptosis in Tumor Cells and Depolarize the Bacterial Cytoplasmic Membrane.
Mokhlesi A, Stuhldreier F, Wex KW, Berscheid A, Hartmann R, Rehberg N, Sureechatchaiyan P, Chaidir C, Kassack MU, Kalscheuer R, Brötz-Oesterhelt H, Wesselborg S, Stork B, Daletos G, Proksch P. J Nat Prod. 2017 Nov 22;80(11):2941-2952. doi: 10.1021/acs.jnatprod.7b00477. Epub 2017 Nov 2. PMID: 29094598

Serum α-1 Antitrypsin (AAT) antagonizes intrinsic apoptosis induction in neutrophils from patients with systemic inflammatory response syndrome.
Sarabhai T, Peter C, Bär AK, Windolf J, Relja B, Wesselborg S, Wahlers T, Paunel-Görgülü A. PLoS One. 2017 May 11;12(5):e0177450. doi: 10.1371/journal.pone.0177450. eCollection 2017. PMID: 2849397

Publications 2016

Efficient and safe gene delivery to human corneal endothelium using magnetic nanoparticles.
Czugala M, Mykhaylyk O, Böhler P, Onderka J, Stork B, Wesselborg S, Kruse FE, Plank C, Singer BB, Fuchsluger TA. Nanomedicine (Lond). 2016 Jul;11(14):1787-800. doi: 10.2217/nnm-2016-0144. Epub 2016 Jul 7. PMID: 27388974

Staurosporine resistance in inflammatory neutrophils is associated with the inhibition of caspase- and proteasome-mediated Mcl-1 degradation.
Hornstein T, Lehmann S, Philipp D, Detmer S, Hoffmann M, Peter C, Wesselborg S, Unfried K, Windolf J, Flohé S, Paunel-Görgülü A. J Leukoc Biol. 2016 Jan;99(1):163-74. doi: 10.1189/jlb.3A1114-537RR. Epub 2015 Aug 26. PMID: 26310832

Publications 2015

Autophagy signal transduction by ATG proteins: from hierarchies to networks.
Wesselborg S, Stork B. Cell Mol Life Sci. 2015 Dec;72(24):4721-57. doi: 10.1007/s00018-015-2034-8. Epub 2015 Sep 21. Review. PMID: 26390974

Platelets induce apoptosis via membrane-bound FasL.
Schleicher RI, Reichenbach F, Kraft P, Kumar A, Lescan M, Todt F, Göbel K, Hilgendorf I, Geisler T, Bauer A, Olbrich M, Schaller M, Wesselborg S, O'Reilly L, Meuth SG, Schulze-Osthoff K, Gawaz M, Li X, Kleinschnitz C, Edlich F, Langer HF. Blood. 2015 Sep 17;126(12):1483-93. doi: 10.1182/blood-2013-12-544445. Epub 2015 Jul 31. Erratum in: Blood. 2016 Jan 14;127(2):270. PMID: 26232171

Expression of a ULK1/2 binding-deficient ATG13 variant can partially restore autophagic activity in ATG13-deficient cells.
Hieke N, Löffler AS, Kaizuka T, Berleth N, Böhler P, Drießen S, Stuhldreier F, Friesen O, Assani K, Schmitz K, Peter C, Diedrich B, Dengjel J, Holland P, Simonsen A, Wesselborg S, Mizushima N, Stork B. Autophagy. 2015;11(9):1471-83. doi: 10.1080/15548627.2015.1068488. PMID: 26213203

Deubiquitinase inhibition by WP1130 leads to ULK1 aggregation and blockade of autophagy.
Drießen S, Berleth N, Friesen O, Löffler AS, Böhler P, Hieke N, Stuhldreier F, Peter C, Schink KO, Schultz SW, Stenmark H, Holland P, Simonsen A, Wesselborg S, Stork B. Autophagy. 2015;11(9):1458-70. doi: 10.1080/15548627.2015.1067359. PMID: 26207339

Phomoxanthone A--From Mangrove Forests to Anticancer Therapy.
Frank M, Niemann H, Böhler P, Stork B, Wesselborg S, Lin W, Proksch P. Curr Med Chem. 2015;22(30):3523-32. Review. PMID: 26179997

Pleiotropic effects of spongean alkaloids on mechanisms of cell death, cell cycle progression and DNA damage response (DDR) of acute myeloid leukemia (AML) cells.
Stuhldreier F, Kassel S, Schumacher L, Wesselborg S, Proksch P, Fritz G. Cancer Lett. 2015 May 28;361(1):39-48. doi: 10.1016/j.canlet.2015.02.030. Epub 2015 Feb 16. PMID: 25697484

Publications 2014

ATG13: just a companion, or an executor of the autophagic program
Alers S, Wesselborg S, Stork B. Autophagy. 2014 Jun;10(6):944-56. doi: 10.4161/auto.28987. Review. Erratum in: Autophagy. 2014 Aug;10(8):1481. PMID: 24879146

Callyspongiolide, a cytotoxic macrolide from the marine sponge Callyspongia sp.
Pham CD, Hartmann R, Böhler P, Stork B, Wesselborg S, Lin W, Lai D, Proksch P. Org Lett. 2014 Jan 3;16(1):266-9. doi: 10.1021/ol403241v. Epub 2013 Dec 13. PMID: 24329175

Publications 2013

PDK1 controls upstream PI3K expression and PIP3 generation.
Dieterle AM, Böhler P, Keppeler H, Alers S, Berleth N, Drießen S, Hieke N, Pietkiewicz S, Löffler AS, Peter C, Gray A, Leslie NR, Shinohara H, Kurosaki T, Engelke M, Wienands J, Bonin M, Wesselborg S, Stork B. Oncogene. 2014 Jun 5;33(23):3043-53. doi: 10.1038/onc.2013.266. Epub 2013 Jul 29. PMID: 23893244

Pro-apoptotic and immunostimulatory tetrahydroxanthone dimers from the endophytic fungus Phomopsis longicolla
Rönsberg D, Debbab A, Mándi A, Vasylyeva V, Böhler P, Stork B, Engelke L, Hamacher A, Sawadogo R, Diederich M, Wray V, Lin W, Kassack MU, Janiak C, Scheu S, Wesselborg S, Kurtán T, Aly AH, Proksch P. J Org Chem. 2013 Dec 20;78(24):12409-25. doi: 10.1021/jo402066b. Epub 2013 Dec 11. PMID: 24295452

The p90 ribosomal S6 kinase (RSK) inhibitor BI-D1870 prevents gamma irradiation-induced apoptosis and mediates senescence via RSK- and p53-independent accumulation of p21WAF1/CIP1.
Neise D, Sohn D, Stefanski A, Goto H, Inagaki M, Wesselborg S, Budach W, Stühler K, Jänicke RU. Cell Death Dis. 2013 Oct 17;4:e859. doi: 10.1038/cddis.2013.386. PMID: 24136223

Milk fat globule-EGF factor 8 mediates the enhancement of apoptotic cell clearance by glucocorticoids.
Lauber K, Keppeler H, Munoz LE, Koppe U, Schröder K, Yamaguchi H, Krönke G, Uderhardt S, Wesselborg S, Belka C, Nagata S, Herrmann M. Cell Death Differ. 2013 Sep;20(9):1230-40. doi: 10.1038/cdd.2013.82. Epub 2013 Jul 5. PMID: 23832117

Vemurafenib potently induces endoplasmic reticulum stress-mediated apoptosis in BRAFV600E melanoma cells.
Beck D, Niessner H, Smalley KS, Flaherty K, Paraiso KH, Busch C, Sinnberg T, Vasseur S, Iovanna JL, Drießen S, Stork B, Wesselborg S, Schaller M, Biedermann T, Bauer J, Lasithiotakis K, Weide B, Eberle J, Schittek B, Schadendorf D, Garbe C, Kulms D, Meier F. Sci Signal. 2013 Jan 29;6(260):ra7. doi: 10.1126/scisignal.2003057. PMID: 23362244


Publications 2012

Serum-derived plasminogen is activated by apoptotic cells and promotes their phagocytic clearance.
Rosenwald M, Koppe U, Keppeler H, Sauer G, Hennel R, Ernst A, Blume KE, Peter C, Herrmann M, Belka C, Schulze-Osthoff K, Wesselborg S, Lauber K. J Immunol. 2012 Dec 15;189(12):5722-8. doi: 10.4049/jimmunol.1200922. Epub 2012 Nov 12. PMID: 23150713

Release of lysophospholipid 'find-me' signals during apoptosis requires the ATP-binding cassette transporter A1.
Peter C, Waibel M, Keppeler H, Lehmann R, Xu G, Halama A, Adamski J, Schulze-Osthoff K, Wesselborg S, Lauber K. Autoimmunity. 2012 Dec;45(8):568-73. doi: 10.3109/08916934.2012.719947. Epub 2012 Sep 17. PMID: 22913458

The incredible ULKs.
Alers S, Löffler AS, Wesselborg S, Stork B. Cell Commun Signal. 2012 Mar 13;10(1):7. doi: 10.1186/1478-811X-10-7. PMID: 22413737

Cleavage of annexin A1 by ADAM10 during secondary necrosis generates a monocytic "find-me" signal.
Blume KE, Soeroes S, Keppeler H, Stevanovic S, Kretschmer D, Rautenberg M, Wesselborg S, Lauber K. J Immunol. 2012 Jan 1;188(1):135-45. doi: 10.4049/jimmunol.1004073. Epub 2011 Nov 23. PMID: 2

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