NK Zellen regulieren anti-virale T Zellen bei fehlendem Typ I Interferon Signal

NK Zellen können T Zellen unterdrücken sofern diese kein Typ I Interferon Signal bekommen. Dieser Mechanismus ist für die Entstehung einer produktiven Immunantwort wichtig. 

Xu et al. Immunity. 2014.

Details.

Das Protein iRhom2 ist wichtig für die TNF-alpha Sekretion

Das Protein iRhom2 trägt wesentlich zur Reifung des Moleküls TACE bei und ist damit ein wichtiger Faktor für die Sekretion von TNF alpha. 

McIlwain et al. Science. 2012.

Details.  Presse. 

Enforced Viral Replication ist ein wichtiger Mechanismus für die Entstehung einer Immunantwort

Der Mechanismus Enforced Viral Replication beschreibt die aktive Virusvermehrung in der Milz um eine spezifische Immunantwort zu generieren. Fehlt dieser Mechanismus kann dies für den Verlauf einer Infektion fatale Folgen haben. 

Honke et al. Nat Immunol. 2011.

Details.

Publikationen

[2018]  [2017]  [2016]  [2015]  [2014]  [2013]  [2012]  [2011]  [2010]  [vor 2010]

Stand: Januar 2019


Publikationen 2018

134. Engelowski E, Modares NF, Gorressen S, Bouvain P, Semmler D, Alter C, Ding Z, Flögel U, Schrader J, Xu H, Lang PA, Fischer J, Floss DM, Scheller J. IL-23R Signaling Plays No Role in Myocardial Infarction. Sci Rep. 2018 Nov 20;8(1):17078.

133. Friedrich SK, Lang PA, Friebus-Kardash J, Duhan V, Bezgovsek J, Lang KS. Mechanisms of lymphatic system-specific viral replication and its potential role in autoimmune disease. Clin Exp Immunol. 2018 Nov 16.

132. Probst K, Stermann J, von Bomhard I, Etich J, Pitzler L, Niehoff A, Bluhm B, Xu HC, Lang PA, Chmielewski M, Abken H, Blissenbach B, Machova A, Papadopoulou N, Brachvogel B. Depletion of Collagen IX Alpha1 Impairs Myeloid Cell Function. Stem Cells. 2018 Nov;36(11):1752-1763.

131. Duggimpudi S, Kloetgen A, Maney SK, Münch PC, Hezaveh K, Shaykhalishahi H, Hoyer W, McHardy AC, Lang PA, Borkhardt A, Hoell JI. Transcriptome-wide analysis uncovers the targets of the RNA-binding protein MSI2 and effects of MSI2's RNA-binding activity on IL-6 signaling. J Biol Chem. 2018 Oct 5;293(40):15359-15369.

130. Osei Kuffour E, Schott K, Jaguva Vasudevan AA, Holler J, Schulz WA, Lang PA, Lang KS, Kim B, Häussinger D, König R, Münk C. USP18 (UBP43) Abrogates p21-Mediated Inhibition of HIV-1. J Virol. 2018 Sep 26;92(20). pii: e00592-18.

129. Lang E, Pozdeev VI, Shinde PV, Xu HC, Sundaram B, Zhuang Y, Poschmann G, Huang J, Stühler K, Pandyra AA, Keitel V, Häussinger D, Lang KS, Lang PA. Cholestasis induced liver pathology results in dysfunctional immune responses after arenavirus infection. Sci Rep. 2018 Aug 15;8(1):12179.

128. Urbahn MA, Kaup SC, Reusswig F, Krüger I, Spelleken M, Jurk K, Klier M, Lang PA, Elvers M. Phospholipase D1 regulation of TNF-alpha protects against responses to LPS. Sci Rep. 2018 Jul 3;8(1):10006.

127. Khairnar V, Duhan V, Patil AM, Zhou F, Bhat H, Thoens C, Sharma P, Adomati T, Friendrich SK, Bezgovsek J, Dreesen JD, Wennemuth G, Westendorf AM, Zelinskyy G, Dittmer U, Hardt C, Timm J, Göthert JR, Lang PA, Singer BB, Lang KS. CEACAM1 promotes CD8+ T cell responses and improves control of a chronic viral infection. Nat Commun. 2018 Jul 2;9(1):2561.

126. Engelowski E, Schneider A, Franke M, Xu H, Clemen R, Lang A, Baran P, Binsch C, Knebel B, Al-Hasani H, Moll JM, Floß DM, Lang PA, Scheller J. Synthetic cytokine receptors transmit biological signals using artificial ligands. Nat Commun. 2018 May 23;9(1):2034.

125. Behnke K, Zhuang Y, Xu HC, Sundaram B, Reich M, Shinde PV, Huang J, Modares NF, Tumanov AV, Polz R, Scheller J, Ware CF, Pfeffer K, Keitel V, Häussinger D, Pandyra AA, Lang KS, Lang PA. B Cell-Mediated Maintenance of Cluster of Differentiation 169-Positive Cells Is Critical for Liver Regeneration. Hepatology. 2018 May 9.

124. Shinde PV, Xu HC, Maney SK, Kloetgen A, Namineni S, Zhuang Y, Honke N, Shaabani N, Bellora N, Doerrenberg M, Trilling M, Pozdeev VI, van Rooijen N, Scheu S, Pfeffer K, Crocker PR, Tanaka M, Duggimpudi S, Knolle P, Heikenwalder M, Ruland J, Mak TW, Brenner D, Pandyra AA, Hoell JI, Borkhardt A, Häussinger D, Lang KS, Lang PA. Tumor Necrosis Factor-Mediated Survival of CD169+ Cells Promotes Immune Activation during Vesicular Stomatitis Virus Infection. J Virol. 2018 Jan 17;92(3). pii: e01637-17.

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Publikationen 2017

123. Xu HC, Huang J, Pandyra AA, Lang E, Zhuang Y, Thöns C, Timm J, Häussinger D, Colonna M, Cantor H, Lang KS, Lang PA. Lymphocytes Negatively Regulate NK Cell Activity via Qa-1b following Viral Infection. Cell Rep. 2017 Nov 28;21(9):2528-2540.

122. Huber M, Suprunenko T, Ashhurst T, Marbach F, Raifer H, Wolff S, Strecker T, Viengkhou B, Jung SR, Obermann HL, Bauer S, Xu HC, Lang PA, Tom A, Lang KS, King NJC, Campbell IL, Hofer MJ. IRF9 Prevents CD8+ T Cell Exhaustion in an Extrinsic Manner during Acute Lymphocytic Choriomeningitis Virus Infection. J Virol. 2017 Oct 27;91(22).

121. Delacher M, Imbusch CD, Weichenhan D, Breiling A, Hotz-Wagenblatt A, Träger U, Hofer AC, Kägebein D, Wang Q, Frauhammer F, Mallm JP, Bauer K, Herrmann C, Lang PA, Brors B, Plass C, Feuerer M. Genome-wide DNA-methylation landscape defines specialization of regulatory T cells in tissues. Nat Immunol. 2017 Oct;18(10):1160-1172.

120. Pozdeev VI, Lang E, Görg B, Bidmon HJ, Shinde PV, Kircheis G, Herebian D, Pfeffer K, Lang F, Häussinger D, Lang KS, Lang PA. TNFα induced up-regulation of Na+,K+,2Cl- cotransporter NKCC1 in hepatic ammonia clearance and cerebral ammonia toxicity. Sci Rep. 2017 Aug 11;7(1):7938

119. Brüstle A, Brenner D, Knobbe-Thomsen CB, Cox M, Lang PA, Lang KS, Mak TW. MALT1 is an intrinsic regulator of regulatory T cells. Cell Death Differ. 2017 Jul;24(7):1214-1223.

118. Mak TW, Grusdat M, Duncan GS, Dostert C, Nonnenmacher Y, Cox M, Binsfeld C, Hao Z, Brüstle A, Itsumi M, Jäger C, Chen Y, Pinkenburg O, Camara B, Ollert M, Bindslev-Jensen C, Vasiliou V, Gorrini C, Lang PA, Lohoff M, Harris IS, Hiller K, Brenner D. Glutathione Primes T Cell Metabolism for Inflammation. Immunity. 2017 Apr 18;46(4):675-689.

117. Kalkavan H, Sharma P, Kasper S, Helfrich I, Pandyra AA, Gassa A, Virchow I, Flatz L, Brandenburg T, Namineni S, Heikenwalder M, Höchst B, Knolle PA, Wollmann G, von Laer D, Drexler I, Rathbun J, Cannon PM, Scheu S, Bauer J, Chauhan J, Häussinger D, Willimsky G, Löhning M, Schadendorf D, Brandau S, Schuler M, Lang PA, Lang KS. Spatiotemporally restricted arenavirus replication induces immune surveillance and type I interferon-dependent tumour regression. Nat Commun. 2017 Mar 1;8:14447.

116. Crome SQ, Nguyen LT, Lopez-Verges S, Yang SY, Martin B, Yam JY, Johnson DJ, Nie J, Pniak M, Yen PH, Milea A, Sowamber R, Katz SR, Bernardini MQ, Clarke BA, Shaw PA, Lang PA, Berman HK, Pugh TJ, Lanier LL, Ohashi PS. A distinct innate lymphoid cell population regulates tumor-associated T cells. Nat Med. 2017 Mar;23(3):368-375.

115. Honke N, Shaabani N, Teijaro JR, Christen U, Hardt C, Bezgovsek J, Lang PA, Lang KS. Presentation of Autoantigen in Peripheral Lymph Nodes Is Sufficient for Priming Autoreactive CD8+ T Cells. Front Immunol. 2017 Feb 10;8:113.

114. Sharma P, Khairnar V, Madunić IV, Singh Y, Pandyra A, Salker MS, Koepsell H, Sabolić I, Lang F, Lang PA, Lang KS. SGLT1 Deficiency Turns Listeria Infection into a Lethal Disease in Mice. Cell Physiol Biochem. 2017;42(4):1358-1365.

113. Honke N, Shaabani N, Hardt C, Krings C, Häussinger D, Lang PA, Lang KS, Keitel V. Farnesoid X Receptor in Mice Prevents Severe Liver Immunopathology During Lymphocytic Choriomeningitis Virus Infection. Cell Physiol Biochem. 2017;41(1):323-338.

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Publikationen 2016

112. Wu T, Ji Y, Moseman EA, Xu HC, Manglani M, Kirby M, Anderson SM, Handon R, Kenyon E, Elkahloun A, Wu W, Lang PA, Gattinoni L, McGavern DB, Schwartzberg PL. The TCF1-Bcl6 axis counteracts type I interferon to repress exhaustion and maintain T cell stemness. Sci Immunol. 2016 Dec 23;1(6). pii: eaai8593.

111. Gil-Cruz C, Perez-Shibayama C, Onder L, Chai Q, Cupovic J, Cheng HW, Novkovic M, Lang PA, Geuking MB, McCoy KD, Abe S, Cui G, Ikuta K, Scandella E, Ludewig B. Fibroblastic reticular cells regulate intestinal inflammation via IL-15-mediated control of group 1 ILCs. Nat Immunol. 2016 Dec;17(12):1388-1396.

110. Shaabani N, Duhan V, Khairnar V, Gassa A, Ferrer-Tur R, Häussinger D, Recher M, Zelinskyy G, Liu J, Dittmer U, Trilling M, Scheu S, Hardt C, Lang PA, Honke N, Lang KS. CD169+ macrophages regulate PD-L1 expression via type I interferon and thereby prevent severe immunopathology after LCMV infection. Cell Death Dis. 2016 Nov 3;7(11):e2446.

109. Beyer M, Abdullah Z, Chemnitz JM, Maisel D, Sander J, Lehmann C, Thabet Y, Shinde PV, Schmidleithner L, Köhne M, Trebicka J, Schierwagen R, Hofmann A, Popov A, Lang KS, Oxenius A, Buch T, Kurts C, Heikenwalder M, Fätkenheuer G, Lang PA, Hartmann P, Knolle PA, Schultze JL. Tumor-necrosis factor impairs CD4(+) T cell-mediated immunological control in chronic viral infection. Nat Immunol. 2016 May;17(5):593-603.

108. Honke N, Shaabani N, Merches K, Gassa A, Kraft A, Ehrhardt K, Häussinger D, Löhning M, Dittmer U, Hengel H, Recher M, Lang PA, Lang KS. Immunoactivation induced by chronic viral infection inhibits viral replication and drives immunosuppression through sustained IFN-I responses. Eur J Immunol. 2016 Feb;46(2):372-80.

107. Shaabani N, Khairnar V, Duhan V, Zhou F, Tur RF, Häussinger D, Recher M, Tumanov AV, Hardt C, Pinschewer D, Christen U, Lang PA, Honke N, Lang KS. Two separate mechanisms of enforced viral replication balance innate and adaptive immune activation. J Autoimmun. 2016 Feb;67:82-89.

106. Duhan V, Khairnar V, Friedrich SK, Zhou F, Gassa A, Honke N, Shaabani N, Gailus N, Botezatu L, Khandanpour C, Dittmer U, Häussinger D, Recher M, Hardt C, Lang PA, Lang KS. Virus-specific antibodies allow viral replication in the marginal zone, thereby promoting CD8(+) T-cell priming and viral control. Sci Rep. 2016 Jan 25;6:19191.

105. Maney SK, Xu HC, Huang J, Pandyra AA, Ehlting C, Aguilar-Valenzuela R, Pozdeev VI, McIlwain DR, Zimmermann A, Bode JG, Hengel H, Kirschning CJ, Kim IR, Hiscott J, Brenner D, Häussinger D, Ohashi PS, Mak TW, Lang KS, Lang PA. RAIDD Mediates TLR3 and IRF7 Driven Type I Interferon Production. Cell Physiol Biochem. 2016;39(4):1271-80.

104. Bhavsar SK, Singh Y, Sharma P, Khairnar V, Hosseinzadeh Z, Zhang S, Palmada M, Sabolic I, Koepsell H, Lang KS, Lang PA, Lang F. Expression of JAK3 Sensitive Na+ Coupled Glucose Carrier SGLT1 in Activated Cytotoxic T Lymphocytes. Cell Physiol Biochem. 2016;39(3):1209-28.

103. Lang E, Pozdeev VI, Xu HC, Shinde PV, Behnke K, Hamdam JM, Lehnert E, Scharf RE, Lang F, Häussinger D, Lang KS, Lang PA. Storage of Erythrocytes Induces Suicidal Erythrocyte Death. Cell Physiol Biochem. 2016;39(2):668-76.

102. Lang E, Pozdeev VI, Gatidis S, Qadri SM, Häussinger D, Kubitz R, Herebian D, Mayatepek E, Lang F, Lang KS, Lang PA. Bile Acid-Induced Suicidal Erythrocyte Death. Cell Physiol Biochem. 2016;38(4):1500-9.

101. Gassa A, Kalkavan H, Jian F, Duhan V, Khairnar V, Shaabani N, Honke N, Carpinteiro A, Botezatu L, Crivello P, Dolff S, Ferencik S, Häussinger D, Khandanpour C, Fleischhauer K, Witzke O, Wahlers T, Hardt C, Lang PA, Lang KS. High Frequencies of Anti-Host Reactive CD8+ T Cells Ignore Non-Hematopoietic Antigen after Bone Marrow Transplantation in a Murine Model. Cell Physiol Biochem. 2016;38(4):1343-53.

100. Gassa A, Jian F, Kalkavan H, Duhan V, Honke N, Shaabani N, Friedrich SK, Dolff S, Wahlers T, Kribben A, Hardt C, Lang PA, Witzke O, Lang KS. IL-10 Induces T Cell Exhaustion During Transplantation of Virus Infected Hearts. Cell Physiol Biochem. 2016;38(3):1171-81.

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Publikationen 2015

99. Lang KS, Lang PA. Balancing viral replication in spleen and liver determines the outcome of systemic virus infection. Gastroenterol. 2015 Dec;53(12):1432-5.

98. Bhattacharya A, Hegazy AN, Deigendesch N, Kosack L, Cupovic J, Kandasamy RK, Hildebrandt A, Merkler D, Kühl AA, Vilagos B, Schliehe C, Panse I, Khamina K, Baazim H, Arnold I, Flatz L, Xu HC, Lang PA, Aderem A, Takaoka A, Superti-Furga G, Colinge J, Ludewig B, Löhning M, Bergthaler A. Superoxide Dismutase 1 Protects Hepatocytes from Type I Interferon-Driven Oxidative Damage. Immunity. 2015 Nov 17;43(5):974-86.

97. Maney SK, McIlwain DR, Polz R, Pandyra AA, Sundaram B, Wolff D, Ohishi K, Maretzky T, Brooke MA, Evers A, Vasudevan AA, Aghaeepour N, Scheller J, Münk C, Häussinger D, Mak TW, Nolan GP, Kelsell DP, Blobel CP, Lang KS, Lang PA. Deletions in the cytoplasmic domain of iRhom1 and iRhom2 promote shedding of the TNF receptor by the protease ADAM17. Sci Signal. 2015 Nov 3;8(401):ra109.

96. Itsumi M, Inoue S, Elia AJ, Murakami K, Sasaki M, Lind EF, Brenner D, Harris IS, Chio II, Afzal S, Cairns RA, Cescon DW, Elford AR, Ye J, Lang PA, Li WY, Wakeham A, Duncan GS, Haight J, You-Ten A, Snow B, Yamamoto K, Ohashi PS, Mak TW. Idh1 protects murine hepatocytes from endotoxin-induced oxidative stress by regulating the intracellular NADP(+)/NADPH ratio. Cell Death Differ. 2015 Nov;22(11):1837-45.

95. Shaabani N, Honke N, Dolff S, Görg B, Khairnar V, Merches K, Duhan V, Metzger S, Recher M, Barthuber C, Hardt C, Proksch P, Häussinger D, Witzke O, Lang PA, Lang KS. IFN-γ licenses CD11b(+) cells to induce progression of systemic lupus erythematosus. J Autoimmun. 2015 Aug;62:11-21.

94. Warsi J, Hosseinzadeh Z, Elvira B, Pelzl L, Shumilina E, Zhang DE, Lang KS, Lang PA, Lang F. USP18 Sensitivity of Peptide Transporters PEPT1 and PEPT2. PLoS One. 2015 Jun 5;10(6):e0129365.

93. Xu HC, Huang J, Khairnar V, Duhan V, Pandyra AA, Grusdat M, Shinde P, McIlwain DR, Maney SK, Gommerman J, Löhning M, Ohashi PS, Mak TW, Pieper K, Sic H, Speletas M, Eibel H, Ware CF, Tumanov AV, Kruglov AA, Nedospasov SA, Häussinger D, Recher M, Lang KS, Lang PA. Deficiency of the B cell-activating factor receptor results in limited CD169+ macrophage function during viral infection. J Virol. 2015 May;89(9):4748-59.

92. Qvartskhava N, Lang PA, Görg B, Pozdeev VI, Ortiz MP, Lang KS, Bidmon HJ, Lang E, Leibrock CB, Herebian D, Bode JG, Lang F, Häussinger D. Hyperammonemia in gene-targeted mice lacking functional hepatic glutamine synthetase. Proc Natl Acad Sci U S A. 2015 Apr 28;112(17):5521-6.

91. Khairnar V, Duhan V, Maney SK, Honke N, Shaabani N, Pandyra AA, Seifert M, Pozdeev V, Xu HC, Sharma P, Baldin F, Marquardsen F, Merches K, Lang E, Kirschning C, Westendorf AM, Häussinger D, Lang F, Dittmer U, Küppers R, Recher M, Hardt C, Scheffrahn I, Beauchemin N, Göthert JR, Singer BB, Lang PA, Lang KS. CEACAM1 induces B-cell survival and is essential for protective antiviral antibody production. Nat Commun. 2015 Feb 18;6:6217.

90. Rahbar R, Lin A, Ghazarian M, Yau HL, Paramathas S, Lang PA, Schildknecht A, Elford AR, Garcia-Batres C, Martin B, Berman HK, Leong WL, McCready DR, Reedijk M, Done SJ, Miller N, Youngson B, Suh WK, Mak TW, Ohashi PS. B7-H4 expression by nonhematopoietic cells in the tumor microenvironment promotes antitumor immunity. Cancer Immunol Res. 2015 Feb;3(2):184-95.

89. McIlwain DR, Grusdat M, Pozdeev VI, Xu HC, Shinde P, Reardon C, Hao Z, Beyer M, Bergthaler A, Häussinger D, Nolan GP, Lang KS, Lang PA. T-cell STAT3 is required for the maintenance of humoral immunity to LCMV. Eur J Immunol. 2015 Feb;45(2):418-27.

88. Lang PA, Meryk A, Pandyra AA, Brenner D, Brüstle A, Xu HC, Merches K, Lang F, Khairnar V, Sharma P, Funkner P, Recher M, Shaabani N, Duncan GS, Duhan V, Homey B, Ohashi PS, Häussinger D, Knolle PA, Honke N, Mak TW, Lang KS. Toso regulates differentiation and activation of inflammatory dendritic cells during persistence-prone virus infection. Cell Death Differ. 2015 Jan;22(1):164-73.

87. Merches K, Khairnar V, Knuschke T, Shaabani N, Honke N, Duhan V, Recher M, Navarini AA, Hardt C, Häussinger D, Tümmler B, Gulbins E, Futerman AH, Hoffmann D, Lang F, Lang PA, Westendorf AM, Lang KS. Virus-Induced Type I Interferon Deteriorates Control of Systemic Pseudomonas Aeruginosa Infection. Cell Physiol Biochem. 2015 Jul 27;36(6):2379-92.

86. Crouse J, Xu HC, Lang PA, Oxenius A. NK cells regulating T cell responses: mechanisms and outcome. Trends Immunol. 2015 Jan;36(1):49-58.

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Publikationen 2014

85. Lang E, Gatidis S, Freise NF, Bock H, Kubitz R, Lauermann C, Orth HM, Klindt C, Schuier M, Keitel V, Reich M, Liu G, Schmidt S, Xu HC, Qadri SM, Herebian D, Pandyra AA, Mayatepek E, Gulbins E, Lang F, Häussinger D, Lang KS, Föller M, Lang PA. Conjugated bilirubin triggers anemia by inducing erythrocyte death. Hepatology. 2014 Jul 28; 61(1):275-84.

84. Aparicio-Siegmund S, Moll JM, Lokau J, Grusdat M, Schröder J, Plöhn S, Rose-John S, Grötzinger J, Lang PA, Scheller J, Garbers C. Recombinant p35 from bacteria can form Interleukin (IL-)12, but Not IL-35. PLoS One. 2014 Sep 26;9(9):e107990.

83. Joedicke JJ, Myers L, Carmody AB, Messer RJ, Wajant H, Lang KS, Lang PA, Mak TW, Hasenkrug KJ, Dittmer U. Activated CD8+ T Cells Induce Expansion of Vβ5+ Regulatory T Cells via TNFR2 Signaling. J Immunol. 2014 Aug 6. pii: 1400649.

82. Parish IA, Marshall HD, Staron MM, Lang PA, Brüstle A, Chen JH, Cui W, Tsui YC, Perry C, Laidlaw BJ, Ohashi PS, Weaver CT, Kaech SM. Chronic viral infection promotes sustained Th1-derived immunoregulatory IL-10 via BLIMP-1. J Clin Invest. 2014 Aug 1;124(8):3455-68.

81. Xu HC, Grusdat M, Pandyra AA, Polz R, Huang J, Sharma P, Deenen R, Köhrer K, Rahbar R, Diefenbach A, Gibbert K, Löhning M, Höcker L, Waibler Z, Häussinger D, Mak TW, Ohashi PS, Lang KS, Lang PA. Type I interferon protects antiviral CD8+ T cells from NK cell cytotoxicity. Immunity. 2014 Jun 19;40(6):949-60.

80. Grusdat M, McIlwain DR, Xu HC, Pozdeev VI, Knievel J, Crome SQ, Robert-Tissot C, Dress RJ, Pandyra AA, Speiser DE, Lang E, Maney SK, Elford AR, Hamilton SR, Scheu S, Pfeffer K, Bode J, Mittrücker HW, Lohoff M, Huber M, Häussinger D, Ohashi PS, Mak TW, Lang KS, Lang PA. IRF4 and BATF are critical for CD8⁺ T-cell function following infection with LCMV. Cell Death Differ. 2014 Jul;21(7):1050-60.

79. Brenner D, Brüstle A, Lin GH, Lang PA, Duncan GS, Knobbe-Thomsen CB, St Paul M, Reardon C, Tusche MW, Snow B, Hamilton SR, Pfefferle A, Gilani SO, Ohashi PS, Lang KS, Mak TW. Toso controls encephalitogenic immune responses by dendritic cells and regulatory T cells. Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):1060-5.

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Publikationen 2013

78. Holderried TA, Lang PA, Kim HJ, Cantor H. Genetic disruption of CD8+ Treg activity enhances the immune response to viral infection. Proc Natl Acad Sci U S A. 2013 Dec 24;110(52):21089-94.

77. Honke N, Shaabani N, Zhang DE, Iliakis G, Xu HC, Häussinger D, Recher M, Löhning M, Lang PA, Lang KS. Usp18 driven enforced viral replication in dendritic cells contributes to break of immunological tolerance in autoimmune diabetes. PLoS Pathog. 2013 Oct;9(10):e1003650. 

76. Garbers C, Kuck F, Aparicio-Siegmund S, Konzak K, Kessenbrock M, Sommerfeld A, Häussinger D,Lang PA, Brenner D, Mak TW, Rose-John S, Essmann F, Schulze-Osthoff K, Piekorz RP, Scheller J. Cellular senescence or EGFR signaling induces Interleukin 6 (IL-6) receptor expression controlled by mammalian target of rapamycin (mTOR). Cell Cycle. 2013 Nov 1;12(21):3421-32.

75. Raczkowski F, Ritter J, Heesch K, Schumacher V, Guralnik A, Höcker L, Raifer H, Klein M, Bopp T, Harb H, Kesper DA, Pfefferle PI, Grusdat M, Lang PA, Mittrücker HW, Huber M. The transcription factor Interferon Regulatory Factor 4 is required for the generation of protective effector CD8+ T cells. Proc Natl Acad Sci U S A. 2013 Sep 10;110(37):15019-24.

74. Maretzky T, McIlwain DR, Issuree PD, Li X, Malapeira J, Amin S, Lang PA, Mak TW, Blobel CP. iRhom2 controls the substrate selectivity of stimulated ADAM17-dependent ectodomain shedding. Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):11433-8. 

73. Crome SQ, Lang PA, Lang KS, Ohashi PS. Natural killer cells regulate diverse T cell responses. Trends Immunol. 2013 Jul;34(7):342-9. 

72. Lang KS, Lang PA, Meryk A, Pandyra AA, Boucher LM, Pozdeev VI, Tusche MW, Göthert JR, Haight J, Wakeham A, You-Ten AJ, McIlwain DR, Merches K, Khairnar V, Recher M, Nolan GP, Hitoshi Y, Funkner P, Navarini AA, Verschoor A, Shaabani N, Honke N, Penn LZ, Ohashi PS, Häussinger D, Lee KH, Mak TW. Involvement of Toso in activation of monocytes, macrophages, and granulocytes. Proc Natl Acad Sci U S A. 2013 Feb 12;110(7):2593-8. 

71. Issuree PD, Maretzky T, McIlwain DR, Monette S, Qing X, Lang PA, Swendeman SL, Park-Min KH, Binder N, Kalliolias GD, Yarilina A, Horiuchi K, Ivashkiv LB, Mak TW, Salmon JE, Blobel CP. iRHOM2 is a critical pathogenic mediator of inflammatory arthritis. J Clin Invest. 2013 Feb 1;123(2):928-32.

70. Lang PA, Xu HC, Grusdat M, McIlwain DR, Pandyra AA, Harris IS, Shaabani N, Honke N, Maney SK, Lang E, Pozdeev VI, Recher M, Odermatt B, Brenner D, Häussinger D, Ohashi PS, Hengartner H, Zinkernagel RM, Mak TW, Lang KS. Reactive oxygen species delay control of lymphocytic choriomeningitis virus. Cell Death Differ. 2013 Apr;20(4):649-58.

69. Lang PA, Shaabani N, Borkens S, Honke N, Scheu S, Booth S, Brenner D, Meryk A, Barthuber C, Recher M, Mak TW, Ohashi PS, Häussinger D, Griffiths GM, Thrasher AJ, Bouma G, Lang KS. Reduced type I interferon production by dendritic cells and weakened antiviral immunity in patients with Wiskott-Aldrich syndrome protein deficiency. J Allergy Clin Immunol. 2013 Mar;131(3):815-24.

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Publikationen 2012

68. Brüstle A, Brenner D, Knobbe CB, Lang PA, Virtanen C, Hershenfield BM, Reardon C, Lacher SM, Ruland J, Ohashi PS, Mak TW. The NF-κB regulator MALT1 determines the encephalitogenic potential of Th17 cells. J Clin Invest. 2012 Dec 3;122(12):4698-709.

67. Chen G, Dimitriou I, Milne L, Lang KS, Lang PA, Fine N, Ohashi PS, Kubes P, Rottapel R. The 3BP2 adapter protein is required for chemoattractant-mediated neutrophil activation. J Immunol. 2012 Sep 1;189(5):2138-50.

66. Kaesler S, Sobiesiak M, Kneilling M, Volz T, Kempf WE, Lang PA, Lang KS, Wieder T, Heller-Stilb B, Warskulat U, Häussinger D, Lang F, Biedermann T. Effective T-cell recall responses require the taurine transporter Taut. Eur J Immunol. 2012 Apr;42(4):831-41.

65. Shaabani N, Honke N, Lang PA, Görg B, Proksch P, Gailus N, Gotoh T, Häussinger D, Lang KS. Tunicamycin inhibits diabetes. Cell Physiol Biochem. 2012;29(3-4):595-602.

64. Recher M, Burns SO, de la Fuente MA, Volpi S, Dahlberg C, Walter JE, Moffitt K, Mathew D, Honke N, Lang PA, Patrizi L, Falet H, Keszei M, Mizui M, Csizmadia E, Candotti F, Nadeau K, Bouma G, Delmonte OM, Frugoni F, Fomin AB, Buchbinder D, Lundequist EM, Massaad MJ, Tsokos GC, Hartwig J, Manis J, Terhorst C, Geha RS, Snapper S, Lang KS, Malley R, Westerberg L, Thrasher AJ, Notarangelo LD. B cell-intrinsic deficiency of the Wiskott-Aldrich syndrome protein (WASp) causes severe abnormalities of the peripheral B-cell compartment in mice. Blood. 2012 Mar 22;119(12):2819-28.

63. McIlwain DR, Lang PA, Maretzky T, Hamada K, Ohishi K, Maney SK, Berger T, Murthy A, Duncan G, Xu HC, Lang KS, Häussinger D, Wakeham A, Itie-Youten A, Khokha R, Ohashi PS, Blobel CP, Mak TW. iRhom2 regulation of TACE controls TNF-mediated protection against Listeria and responses to LPS. Science. 2012 Jan 13;335(6065):229-32. 

62. Hao Z, Duncan GS, Su YW, Li WY, Silvester J, Hong C, You H, Brenner D, Gorrini C, Haight J, Wakeham A, You-Ten A, McCracken S, Elia A, Li Q, Detmar J, Jurisicova A, Hobeika E, Reth M, Sheng Y, Lang PA, Ohashi PS, Zhong Q, Wang X, Mak TW. The E3 ubiquitin ligase Mule acts through the ATM-p53 axis to maintain B lymphocyte homeostasis. J Exp Med. 2012 Jan 16;209(1):173-86. 

61. Wang C, McPherson AJ, Jones RB, Kawamura KS, Lin GH, Lang PA, Ambagala T, Pellegrini M, Calzascia T, Aidarus N, Elford AR, Yue FY, Kremmer E, Kovacs CM, Benko E, Tremblay C, Routy JP, Bernard NF, Ostrowski MA, Ohashi PS, Watts TH. Loss of the signaling adaptor TRAF1 causes CD8+ T cell dysregulation during human and murine chronic infection. J Exp Med. 2012 Jan 16;209(1):77-91.

60. Lang PA, Lang KS, Xu HC, Grusdat M, Parish IA, Recher M, Elford AR, Dhanji S, Shaabani N, Tran CW, Dissanayake D, Rahbar R, Ghazarian M, Brüstle A, Fine J, Chen P, Weaver CT, Klose C, Diefenbach A, Häussinger D, Carlyle JR, Kaech SM, Mak TW, Ohashi PS. Natural killer cell activation enhances immune pathology and promotes chronic infection by limiting CD8+ T-cell immunity. Proc Natl Acad Sci U S A. 2012 Jan 24;109(4):1210-5.

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Publikationen 2011

59. Honke N, Shaabani N, Cadeddu G, Sorg UR, Zhang DE, Trilling M, Klingel K, Sauter M, Kandolf R, Gailus N, van Rooijen N, Burkart C, Baldus SE, Grusdat M, Löhning M, Hengel H, Pfeffer K, Tanaka M, Häussinger D, Recher M, Lang PA, Lang KS. Enforced viral replication activates adaptive immunity and is essential for the control of a cytopathic virus. Nat Immunol. 2011 Nov 20;13(1):51-7.

58. Lang PA, Graf D, Boini KM, Lang KS, Klingel K, Kandolf R, Lang F. Cell volume, the serum and glucocorticoid inducible kinase 1 and the liver. Z Gastroenterol. 2011 Jun;49(6):713-9.

57. Nguyen XH, Lang PA, Lang KS, Adam D, Fattakhova G, Föger N, Kamal MA, Prilla P, Mathieu S, Wagner C, Mak T, Chan AC, Lee KH. Toso regulates the balance between apoptotic and nonapoptotic death receptor signaling by facilitating RIP1 ubiquitination. Blood. 2011 Jul 21;118(3):598-608.

56. Pellegrini M, Calzascia T, Toe JG, Preston SP, Lin AE, Elford AR, Shahinian A, Lang PA, Lang KS, Morre M, Assouline B, Lahl K, Sparwasser T, Tedder TF, Paik JH, DePinho RA, Basta S, Ohashi PS, Mak TW. IL-7 engages multiple mechanisms to overcome chronic viral infection and limit organ pathology. Cell. 2011 Feb 18;144(4):601-13.

55. Su YW, Hao Z, Hirao A, Yamamoto K, Lin WJ, Young A, Duncan GS, Yoshida H, Wakeham A, Lang PA, Murakami K, Hermeking H, Vogelstein B, Ohashi P, Mak TW. 14-3-3sigma regulates B-cell homeostasis through stabilization of FOXO1. Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1555-60.

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Publikationen 2010

54. Lang PA, Recher M, Häussinger D, Lang KS. Genes determining the course of virus persistence in the liver: lessons from murine infection with lymphocytic choriomeningitis virus. Cell Physiol Biochem. 2010;26(3):263-72.

53. Lang PA, Merkler D, Funkner P, Shaabani N, Meryk A, Krings C, Barthuber C, Recher M, Brück W, Häussinger D, Ohashi PS, Lang KS. Oxidized ATP inhibits T-cell-mediated autoimmunity. Eur J Immunol. 2010 Sep;40(9):2401-8.

52. Lang PA, Recher M, Honke N, Scheu S, Borkens S, Gailus N, Krings C, Meryk A, Kulawik A, Cervantes-Barragan L, Van Rooijen N, Kalinke U, Ludewig B, Hengartner H, Harris N, Häussinger D, Ohashi PS, Zinkernagel RM, Lang KS. Tissue macrophages suppress viral replication and prevent severe immunopathology in an interferon-I-dependent manner in mice. Hepatology. 2010 Jul;52(1):25-32.

51. Walter JE, Rucci F, Patrizi L, Recher M, Regenass S, Paganini T, Keszei M, Pessach I, Lang PA, Poliani PL, Giliani S, Al-Herz W, Cowan MJ, Puck JM, Bleesing J, Niehues T, Schuetz C, Malech H, DeRavin SS, Facchetti F, Gennery AR, Andersson E, Kamani NR, Sekiguchi J, Alenezi HM, Chinen J, Dbaibo G, ElGhazali G, Fontana A, Pasic S, Detre C, Terhorst C, Alt FW, Notarangelo LD. Expansion of immunoglobulin-secreting cells and defects in B cell tolerance in Rag-dependent immunodeficiency. J Exp Med. 2010 Jul 5;207(7):1541-54.

50. Lang F, Gulbins E, Lang PA, Zappulla D, Föller M. Ceramide in suicidal death of erythrocytes. Cell Physiol Biochem. 2010;26(1):21-8.

49. Lang E, Lang PA, Shumilina E, Qadri SM, Kucherenko Y, Kempe DS, Föller M, Capasso A, Wieder T, Gulbins E, Clemen CS, Herr C, Noegel AA, Huber SM, Lang F. Enhanced eryptosis of erythrocytes from gene-targeted mice lacking annexin A7. Pflugers Arch. 2010 Aug;460(3):667-76. 

Publikationen vor 2010

48. Lang PA, Kasinathan RS, Brand VB, Duranton C, Lang C, Koka S, Shumilina E, Kempe DS, Tanneur V, Akel A, Lang KS, Foller M, Kun JF, Kremsner PG, Wesselborg S, Laufer S, Clemen CS, Herr C, Noegel AA, Wieder T, Gulbins E, Lang F, Huber SM. Accelerated clearance of Plasmodium-infected erythrocytes in sickle cell trait and annexin-A7 deficiency. Cell Physiol Biochem. 2009;24(5-6):415-28. 

47. Lupescu A, Geiger C, Zahir N, Aberle S, Lang PA, Kramer S, Wesselborg S, Kandolf R, Foller M, Lang F, Bock CT. Inhibition of Na+/H+ exchanger activity by parvovirus B19 protein NS1. Cell Physiol Biochem. 2009;23(1-3):211-20.

46. Lang PA, Cervantes-Barragan L, Verschoor A, Navarini AA, Recher M, Pellegrini M, Flatz L, Bergthaler A, Honda K, Ludewig B, Ohashi PS, Lang KS. Hematopoietic cell-derived interferon controls viral replication and virus-induced disease. Blood. 2009 Jan 29;113(5):1045-52.

45. Lang PA, Contaldo C, Georgiev P, El-Badry AM, Recher M, Kurrer M, Cervantes-Barragan L, Ludewig B, Calzascia T, Bolinger B, Merkler D, Odermatt B, Bader M, Graf R, Clavien PA, Hegazy AN, Löhning M, Harris NL, Ohashi PS, Hengartner H, Zinkernagel RM, Lang KS. Aggravation of viral hepatitis by platelet-derived serotonin. Nat Med. 2008 Jul;14(7):756-61. 

44. Lang KS, Hegazy AN, Lang PA, Eschli B, Löhning M, Hengartner H, Zinkernagel RM, Recher M. "Negative vaccination" by specific CD4 T cell tolerisation enhances virus-specific protective antibody responses. PLoS One. 2007 Nov 14;2(11):e1162.

43. Recher M, Lang KS, Navarini A, Hunziker L, Lang PA, Fink K, Freigang S, Georgiev P, Hangartner L, Zellweger R, Bergthaler A, Hegazy AN, Eschli B, Theocharides A, Jeker LT, Merkler D, Odermatt B, Hersberger M, Hengartner H, Zinkernagel RM. Extralymphatic virus sanctuaries as a consequence of potent T-cell activation. Nat Med. 2007 Nov;13(11):1316-23.

42. Junt T, Moseman EA, Iannacone M, Massberg S, Lang PA, Boes M, Fink K, Henrickson SE, Shayakhmetov DM, Di Paolo NC, van Rooijen N, Mempel TR, Whelan SP, von Andrian UH. Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells. Nature. 2007 Nov 1;450(7166):110-4.

41. Lang KS, Burow A, Kurrer M, Lang PA, Recher M. The role of the innate immune response in autoimmune disease. J Autoimmun. 2007 Dec;29(4):206-12.

40. Attanasio P, Shumilina E, Hermle T, Kiedaisch V, Lang PA, Huber SM, Wieder T, Lang F. Stimulation of eryptosis by anti-A IgG antibodies. Cell Physiol Biochem. 2007;20(5):591-600.

39. Lang PA, Schniepp R, Kirchhoff P, Socrates T, Sidani SM, Geibel JP. PI3 kinase dependent stimulation of gastric acid secretion by dexamethasone. Cell Physiol Biochem. 2007;20(5):527-34.

38. Lang KS, Navarini AA, Recher M, Lang PA, Heikenwalder M, Stecher B, Bergthaler A, Odermatt B, Akira S, Honda K, Hengartner H, Zinkernagel RM. MyD88 protects from lethal encephalitis during infection with vesicular stomatitis virus. Eur J Immunol. 2007 Sep;37(9):2434-40.

37. Lang PA, Schenck M, Nicolay JP, Becker JU, Kempe DS, Lupescu A, Koka S, Eisele K, Klarl BA, Rübben H, Schmid KW, Mann K, Hildenbrand S, Hefter H, Huber SM, Wieder T, Erhardt A, Häussinger D, Gulbins E, Lang F. Liver cell death and anemia in Wilson disease involve acid sphingomyelinase and ceramide. Nat Med. 2007 Feb;13(2):164-70.

36. Kempe DS, Akel A, Lang PA, Hermle T, Biswas R, Muresanu J, Friedrich B, Dreischer P, Wolz C, Schumacher U, Peschel A, Götz F, Döring G, Wieder T, Gulbins E, Lang F. Suicidal erythrocyte death in sepsis. J Mol Med (Berl). 2007 Mar;85(3):273-81. 

35. Niemoeller OM, Akel A, Lang PA, Attanasio P, Kempe DS, Hermle T, Sobiesiak M, Wieder T, Lang F. Induction of eryptosis by cyclosporine. Naunyn Schmiedebergs Arch Pharmacol. 2006 Oct;374(1):41-9.

34. Lupescu A, Bock CT, Lang PA, Aberle S, Kaiser H, Kandolf R, Lang F. Phospholipase A2 activity-dependent stimulation of Ca2+ entry by human parvovirus B19 capsid protein VP1. J Virol. 2006 Nov;80(22):11370-80.

33. Lang PA, Huober J, Bachmann C, Kempe DS, Sobiesiak M, Akel A, Niemoeller OM, Dreischer P, Eisele K, Klarl BA, Gulbins E, Lang F, Wieder T. Stimulation of erythrocyte phosphatidylserine exposure by paclitaxel. Cell Physiol Biochem. 2006;18(1-3):151-64. 

32. Lang F, Lang KS, Lang PA, Huber SM, Wieder T. Mechanisms and significance of eryptosis. Antioxid Redox Signal. 2006 Jul-Aug;8(7-8):1183-92.

31. Lang F, Lang KS, Lang PA, Huber SM, Wieder T. Osmotic shock-induced suicidal death of erythrocytes. Acta Physiol (Oxf). 2006 May-Jun;187(1-2):191-8.

30. Hermle T, Shumilina E, Attanasio P, Akel A, Kempe DS, Lang PA, Podolski M, Gatz S, Bachmann R, Bachmann C, Abele H, Huber S, Wieder T, Lang F. Decreased cation channel activity and blunted channel-dependent eryptosis in neonatal erythrocytes. Am J Physiol Cell Physiol. 2006 Oct;291(4):C710-7. 

29. Lang PA, Beringer O, Nicolay JP, Amon O, Kempe DS, Hermle T, Attanasio P, Akel A, Schäfer R, Friedrich B, Risler T, Baur M, Olbricht CJ, Zimmerhackl LB, Zipfel PF, Wieder T, Lang F. Suicidal death of erythrocytes in recurrent hemolytic uremic syndrome. J Mol Med (Berl). 2006 May;84(5):378-88.

28. Akel A, Hermle T, Niemoeller OM, Kempe DS, Lang PA, Attanasio P, Podolski M, Wieder T, Lang F. Stimulation of erythrocyte phosphatidylserine exposure by chlorpromazine. Eur J Pharmacol. 2006 Feb 17;532(1-2):11-7. 

27. Kempe DS, Lang PA, Duranton C, Akel A, Lang KS, Huber SM, Wieder T, Lang F. Enhanced programmed cell death of iron-deficient erythrocytes. FASEB J. 2006 Feb;20(2):368-70. 

26. Shumilina E, Kiedaisch V, Akkel A, Lang P, Hermle T, Kempe DS, Huber SM, Wieder T, Laufer S, Lang F. Stimulation of suicidal erythrocyte death by lipoxygenase inhibitor Bay-Y5884. Cell Physiol Biochem. 2006;18(4-5):233-42.

25. Klarl BA, Lang PA, Kempe DS, Niemoeller OM, Akel A, Sobiesiak M, Eisele K, Podolski M, Huber SM, Wieder T, Lang F. Protein kinase C mediates erythrocyte "programmed cell death" following glucose depletion. Am J Physiol Cell Physiol. 2006 Jan;290(1):C244-53.

24. Huang DY, Boini KM, Lang PA, Grahammer F, Duszenko M, Heller-Stilb B, Warskulat U, Häussinger D, Lang F, Vallon V. Impaired ability to increase water excretion in mice lacking the taurine transporter gene TAUT. Pflugers Arch. 2006 Feb;451(5):668-77.

23. Eisele K, Lang PA, Kempe DS, Klarl BA, Niemöller O, Wieder T, Huber SM, Duranton C, Lang F. Stimulation of erythrocyte phosphatidylserine exposure by mercury ions. Toxicol Appl Pharmacol. 2006 Jan 1;210(1-2):116-22.

22. Lang PA, Kempe DS, Akel A, Klarl BA, Eisele K, Podolski M, Hermle T, Niemoeller OM, Attanasio P, Huber SM, Wieder T, Lang F, Duranton C. Inhibition of erythrocyte "apoptosis" by catecholamines. Naunyn Schmiedebergs Arch Pharmacol. 2005 Nov;372(3):228-35.

21. Lang KS, Lang PA, Bauer C, Duranton C, Wieder T, Huber SM, Lang F. Mechanisms of suicidal erythrocyte death. Cell Physiol Biochem. 2005;15(5):195-202. 

20. Lang PA, Kempe DS, Myssina S, Tanneur V, Birka C, Laufer S, Lang F, Wieder T, Huber SM. PGE(2) in the regulation of programmed erythrocyte death. Cell Death Differ. 2005 May;12(5):415-28.

19. Lang PA, Kempe DS, Tanneur V, Eisele K, Klarl BA, Myssina S, Jendrossek V, Ishii S, Shimizu T, Waidmann M, Hessler G, Huber SM, Lang F, Wieder T. Stimulation of erythrocyte ceramide formation by platelet-activating factor. J Cell Sci. 2005 Mar 15;118(Pt 6):1233-43. 

18. Kempe DS, Lang PA, Eisele K, Klarl BA, Wieder T, Huber SM, Duranton C, Lang F. Stimulation of erythrocyte phosphatidylserine exposure by lead ions. Am J Physiol Cell Physiol. 2005 Feb;288(2):C396-402.

17. Lang F, Föller M, Lang KS, Lang PA, Ritter M, Gulbins E, Vereninov A, Huber SM. Ion channels in cell proliferation and apoptotic cell death. J Membr Biol. 2005 Jun;205(3):147-57. 

16. Lang F, Gulbins E, Szabo I, Lepple-Wienhues A, Huber SM, Duranton C, Lang KS, Lang PA, Wieder T. Cell volume and the regulation of apoptotic cell death. J Mol Recognit. 2004 Sep-Oct;17(5):473-80.

15. Lang F, Birka C, Myssina S, Lang KS, Lang PA, Tanneur V, Duranton C, Wieder T, Huber SM. Erythrocyte ion channels in regulation of apoptosis. Adv Exp Med Biol. 2004;559:211-7.

14. Myssina S, Lang PA, Kempe DS, Kaiser S, Huber SM, Wieder T, Lang F. Cl- channel blockers NPPB and niflumic acid blunt Ca(2+)-induced erythrocyte 'apoptosis'. Cell Physiol Biochem. 2004;14(4-6):241-8.

13. Birka C, Lang PA, Kempe DS, Hoefling L, Tanneur V, Duranton C, Nammi S, Henke G, Myssina S, Krikov M, Huber SM, Wieder T, Lang F. Enhanced susceptibility to erythrocyte "apoptosis" following phosphate depletion. Pflugers Arch. 2004 Aug;448(5):471-7. 

12. Jeck N, Waldegger S, Lampert A, Boehmer C, Waldegger P, Lang PA, Wissinger B, Friedrich B, Risler T, Moehle R, Lang UE, Zill P, Bondy B, Schaeffeler E, Asante-Poku S, Seyberth H, Schwab M, Lang F. Activating mutation of the renal epithelial chloride channel ClC-Kb predisposing to hypertension. Hypertension. 2004 Jun;43(6):1175-81.

11. Lang KS, Myssina S, Lang PA, Tanneur V, Kempe DS, Mack AF, Huber SM, Wieder T, Lang F, Duranton C. Inhibition of erythrocyte phosphatidylserine exposure by urea and Cl-. Am J Physiol Renal Physiol. 2004 Jun;286(6):F1046-53.

10. Lang F, Lang PA, Lang KS, Brand V, Tanneur V, Duranton C, Wieder T, Huber SM. Channel-induced apoptosis of infected host cells-the case of malaria. Pflugers Arch. 2004 Jun;448(3):319-24. 

9. Lang PA, Kaiser S, Myssina S, Birka C, Weinstock C, Northoff H, Wieder T, Lang F, Huber SM. Effect of Vibrio parahaemolyticus haemolysin on human erythrocytes. Cell Microbiol. 2004 Apr;6(4):391-400.

8. Lang KS, Myssina S, Brand V, Sandu C, Lang PA, Berchtold S, Huber SM, Lang F, Wieder T. Involvement of ceramide in hyperosmotic shock-induced death of erythrocytes. Cell Death Differ. 2004 Feb;11(2):231-43.

7. Lang PA, Warskulat U, Heller-Stilb B, Huang DY, Grenz A, Myssina S, Duszenko M, Lang F, Häussinger D, Vallon V, Wieder T. Blunted apoptosis of erythrocytes from taurine transporter deficient mice. Cell Physiol Biochem. 2003;13(6):337-46.

6. Lang PA, Kaiser S, Myssina S, Wieder T, Lang F, Huber SM. Role of Ca2+-activated K+ channels in human erythrocyte apoptosis. Am J Physiol Cell Physiol. 2003 Dec;285(6):C1553-60.

5. Myssina S, Huber SM, Birka C, Lang PA, Lang KS, Friedrich B, Risler T, Wieder T, Lang F. Inhibition of erythrocyte cation channels by erythropoietin. J Am Soc Nephrol. 2003 Nov;14(11):2750-7.

4.  Lang F, Lang KS, Wieder T, Myssina S, Birka C, Lang PA, Kaiser S, Kempe D, Duranton C, Huber SM. Cation channels, cell volume and the death of an erythrocyte. Pflugers Arch. 2003 Nov;447(2):121-5. 

3. Gamper N, Fillon S, Feng Y, Friedrich B, Lang PA, Henke G, Huber SM, Kobayashi T, Cohen P, Lang F. K+ channel activation by all three isoforms of serum- and glucocorticoid-dependent protein kinase SGK. Pflugers Arch. 2002 Oct;445(1):60-6.

2. Wärntges S, Friedrich B, Henke G, Duranton C, Lang PA, Waldegger S, Meyermann R, Kuhl D, Speckmann EJ, Obermüller N, Witzgall R, Mack AF, Wagner HJ, Wagner A, Bröer S, Lang F. Cerebral localization and regulation of the cell volume-sensitive serum- and glucocorticoid-dependent kinase SGK1. Pflugers Arch. 2002 Feb;443(4):617-24.

1. Albers A, Bröer A, Wagner CA, Setiawan I, Lang PA, Kranz EU, Lang F, Bröer S. Na+ transport by the neural glutamine transporter ATA1. Pflugers Arch. 2001 Oct;443(1):92-101.

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