REFERENZEN NEUROIMMUNOLOGIE
1. Bleck D, Ma L, Erdene-Bymbadoo L, Brinks R, Schneider M, Tian L, Pongratz G.
Introduction and validation of a new semi-automated method to determine sympathetic fiber density in target tissues. PLoS One. 2019 May 29;14(5):e0217475.
2. Lowin T, Schneider M, Pongratz G.
Joints for joints: cannabinoids in the treatment of rheumatoid arthritis. Curr Opin Rheumatol. 2019 May;31(3):271-278.
3. Ruthard J, Hermes G, Hartmann U, Sengle G, Pongratz G, Ostendorf B, Schneider M, Höllriegl S, Zaucke F, Wagener R, Streichert T, Klatt AR.
Identification of antibodies against extracellular matrix proteins in human osteoarthritis. Biochem Biophys Res Commun. 2018 Sep 10;503(3):1273-1277.
4. Lowin T, Bleck J, Schneider M, Pongratz G.
Selective killing of proinflammatory synovial fibroblasts via activation of transient receptor potential ankyrin (TRPA1). Biochem Pharmacol. 2018 Aug;154:293-302.
5. Pongratz G.
Glucocorticoid therapy in rheumatoid arthritis - pro. Dtsch Med Wochenschr. 2016 Oct;141(22):1650. Epub 2016 Nov 4. Review.
6. Lowin T, Pongratz G, Straub RH
The synthetic cannabinoid WIN55,212-2 mesylate decreases the production of inflammatory mediators in rheumatoid arthritis synovial fibroblasts by activating CB2, TRPV1, TRPA1 and yet unidentified receptor targets. J Inflamm. 2016. J Inflamm (Lond). 2016 May 5;13:15.
7. Klatt S, Stangl H, Kunath J, Lowin T, Pongratz G, Straub RH
Peripheral elimination of the sympathetic nervous system stimulates immunocyte retention in lymph nodes and ameliorates collagen type II arthritis. Brain Behav. Immun. 2016. Brain Behav Immun 54, 201-10.
8. Lowin T, Pongratz G, Straub RH
The synthetic cannabinoid WIN55,212-2 mesylate decreases the production of inflammatory mediators in rheumatoid arthritis synovial fibroblasts by activating CB2, TRPV1, TRPA1 and yet unidentified receptor targets. J Inflamm. 2016. Im Druck
9. Klatt S, Stangl H, Kunath J, Lowin T, Pongratz G, Straub RH
Peripheral elimination of the sympathetic nervous system stimulates immunocyte retention in lymph nodes and ameliorates collagen type II arthritis. Brain Behav. Immun. 2016. Im Druck
10. Lowin T, Apitz M, Anders S, Straub RH
Anti-inflammatory effects of N-acylethanolamines in rheumatoid arthritis synovial cells are mediated by TRPV1 and TRPA1 in a COX-2 dependent manner. Arthritis Res Ther. 2015 Nov 14;17(1):321. doi: 10.1186/s13075-015-0845-5
11. Lowin T, Straub RH
Cannabinoid-based drugs targeting CB1 and TRPV1, the sympathetic nervous system, and arthritis. Arthritis Res Ther. 2015 Sep 6;17:226. doi: 10.1186/s13075-015-0743-x.
12. Lowin T, Straub RH
Synovial fibroblasts integrate inflammatory and neuroendocrine stimuli to drive rheumatoid arthritis. Expert Rev Clin Immunol. 2015;11(10):1069-71. doi: 10.1586/1744666X.2015.1066674
13. Jenei-Lanzl Z, Capellino S, Kees F, Fleck M, Lowin T, Straub RH
Anti-inflammatory effects of cell-based therapy with tyrosine hydroxylase-positive catecholaminergic cells in experimental arthritis. Ann Rheum Dis. 2015 Feb;74(2):444-51. doi: 10.1136/annrheumdis-2013-203925.
14. Capellino S, Cosentino M, Luini A, Bombelli R, Lowin T, Cutolo M, Marino F, Straub RH
Increased expression of dopamine receptors in synovial fibroblasts from patients with rheumatoid arthritis: inhibitory effects of dopamine on interleukin-8 and interleukin-6. Arthritis Rheumatol. 2014 Oct;66(10):2685-93. doi: 10.1002/art.38746.
15. Jenei-Lanzl Z, Grässel S, Pongratz G, Kees F, Miosge N, Angele P, Straub RH
Norepinephrine inhibition of mesenchymal stem cell and chondrogenic progenitor cell chondrogenesis and acceleration of chondrogenic hypertrophy. Arthritis Rheumatol. 2014 Sep;66(9):2472-81. doi: 10.1002/art.38695
16. Pongratz G, Anthofer JM, Melzer M, Anders S, Grässel S, Straub RH
IL-7 receptor α expressing B cells act proinflammatory in collagen-induced arthritis and are inhibited by sympathetic neurotransmitters. Ann Rheum Dis. 2014 Jan;73(1):306-12. doi: 10.1136/annrheumdis-2012-202944. Epub 2013 Mar 16.
17. Pongratz G, Straub RH
The sympathetic nervous response in inflammation. Arthritis Res Ther. 2014;16(6):504. Review. PubMed PMID: 25789375;
18. Meinel T, Pongratz G, Rauch L, Straub RH
Neuronal α1/2-adrenergic stimulation of IFN-γ, IL-6, and CXCL-1 in murine spleen in late experimental arthritis. Brain Behav Immun. 2013 Oct;33:80-9. doi: 10.1016/j.bbi.2013.06.003. Epub 2013 Jun 17.
19. Lowin T, Zhu W, Dettmer-Wilde K, Straub RH
Cortisol-mediated adhesion of synovial fibroblasts is dependent on the degradation of anandamide and activation of the endocannabinoid system. Arthritis Rheum. 2012 Dec;64(12):3867-76. doi: 10.1002/art.37684.
20. Pongratz G, Straub RH
Role of peripheral nerve fibres in acute and chronic inflammation in arthritis. Nat Rev Rheumatol. 2013 Feb;9(2):117-26. doi: 10.1038/nrrheum.2012.181. Epub 2012 Nov 13. Review.
21. Lowin T, Weidler C, Jenei-Lanzl Z, Capellino S, Baerwald CG, Buttgereit F, Straub RH
Relationship between placenta growth factor 1 and vascularization, dehydroepiandrosterone sulfate to dehydroepiandrosterone conversion, or aromatase expression in patients with rheumatoid arthritis and patients with osteoarthritis. Arthritis Rheum. 2012 Jun;64(6):1799-808. doi: 10.1002/art.34338.
22. Pongratz G, Melzer M, Straub RH
The sympathetic nervous system stimulates anti-inflammatory B cells in collagen-type II-induced arthritis. Ann Rheum Dis. 2012 Mar;71(3):432-9. doi: 10.1136/ard.2011.153056. Epub 2011 Sep 27.
23. Straub RH, Rauch L, Rauh L, Pongratz G
Sympathetic inhibition of IL-6, IFN-γ, and KC/CXCL1 and sympathetic stimulation of TGF-β in spleen of early arthritic mice. Brain Behav Immun. 2011 Nov;25(8):1708-15. doi: 10.1016/j.bbi.2011.07.001. Epub 2011 Jul 13.
24. Straub RH, Lowin T, Klatt S, Wolff C, Rauch L
Increased density of sympathetic nerve fibers in metabolically activated fat tissue surrounding human synovium and mouse lymph nodes in arthritis. Arthritis Rheum. 2011 Nov;63(11):3234-42. doi: 10.1002/art.30516.
25. Lowin T, Straub RH
Integrins and their ligands in rheumatoid arthritis. Arthritis Res Ther. 2011;13(5):244. doi: 10.1186/ar3464.
26. Straub RH, Cutolo M, Buttgereit F, Pongratz G
Energy regulation and neuroendocrine-immune control in chronic inflammatory diseases. J Intern Med. 2010 Jun;267(6):543-60. doi: 10.1111/j.1365-2796.2010.02218.x. Epub 2010 Jan 28. Review.
27. Lowin T, Straub RH, Neumann E, Bosserhoff A, Vogel C, Moissl C, Anders S, Müller-Ladner U, Schedel J
Glucocorticoids increase alpha5 integrin expression and adhesion of synovial fibroblasts but inhibit ERK signaling, migration, and cartilage invasion. Arthritis Rheum. 2009 Dec;60(12):3623-32. doi: 10.1002/art.24985.
28. Schubert T, Denk A, Mägdefrau U, Kaufmann S, Bastone P, Lowin T, Schedel J, Bosserhoff AK
Role of the netrin system of repellent factors on synovial fibroblasts in rheumatoid arthritis and osteoarthritis. Int J Immunopathol Pharmacol. 2009 Jul-Sep;22(3):715-22.
29. Pongratz G, Straub RH
The B cell, arthritis, and the sympathetic nervous system. Brain Behav Immun. 2010 Feb;24(2):186-92. doi: 10.1016/j.bbi.2009.07.002. Epub 2009 Jul 16. Review.
30. Straub RH, Pongratz G, Hirvonen H, Pohjolainen T, Mikkelsson M, Leirisalo-Repo M
Acute cold stress in rheumatoid arthritis inadequately activates stress responses and induces an increase of interleukin 6. Ann Rheum Dis. 2009 Apr;68(4):572-8. doi: 10.1136/ard.2008.089458. Epub 2008 Apr 15.
31. Straub RH, Rauch L, Fassold A, Lowin T, Pongratz G
Neuronally released sympathetic neurotransmitters stimulate splenic interferon-gamma secretion from T cells in early type II collagen-induced arthritis. Arthritis Rheum. 2008 Nov;58(11):3450-60. doi: 10.1002/art.24030. Erratum in: Arthritis Rheum. 2012 May;64(5):1695-6.
32. Härle P, Pongratz G, Albrecht J, Tarner IH, Straub RH
An early sympathetic nervous system influence exacerbates collagen-induced arthritis via CD4+CD25+ cells. Arthritis Rheum. 2008 Aug;58(8):2347-55. doi: 10.1002/art.23628.
33. Pongratz G, Straub RH
B-cell involvement in the pathogenesis of RA-is there a contribution of the sympathetic nervous system? Immunol Res. 2008;40(2):148-63. doi: 10.1007/s12026-007-8002-0. Review.
34. Capellino S, Lowin T, Angele P, Falk W, Grifka J, Straub RH
Increased chromogranin A levels indicate sympathetic hyperactivity in patients with rheumatoid arthritis and systemic lupus erythematosus. J Rheumatol. 2008 Jan;35(1):91-9.
35. Pongratz G, McAlees JW, Conrad DH, Erbe RS, Haas KM, Sanders VM
The level of IgE produced by a B cell is regulated by norepinephrine in a p38 MAPK- and CD23-dependent manner. J Immunol. 2006 Sep 1;177(5):2926-38.
36. Straub RH, Pongratz G, Weidler C, Linde HJ, Kirschning CJ, Glück T, Schölmerich J, Falk W
Ablation of the sympathetic nervous system decreases gram-negative and increases gram-positive bacterial dissemination: key roles for tumor necrosis factor/phagocytes and interleukin-4/lymphocytes. J Infect Dis.2005 Aug 15;192(4):560-72. Epub 2005 Jul 15.
37. Pongratz G, Härle P, Schnellinger G, Janele D, Schölmerich J, Straub RH
Norepinephrine in mice inhibits secretion of splenic IL-6 during the dark period but stimulates its secretion in the light period--possible role of the corticosterone tone. J Neuroimmunol. 2005 Jan;158(1-2):120-7.
38. Kees MG, Pongratz G, Kees F, Schölmerich J, Straub RH
Via beta-adrenoceptors, stimulation of extrasplenic sympathetic nerve fibers inhibits lipopolysaccharide-induced TNF secretion in perfused rat spleen. J Neuroimmunol. 2003 Dec;145(1-2):77-85.