Institut für Pathologie - Publikationen 2015

Benitz S, Regel I, Reinhard T, Popp A, Schäffer I, Raulefs S, Kong B, Esposito I, Michalski CW, Kleeff J.
Polycomb repressor complex 1 promotes gene silencing through H2AK119 mono-ubiquitination in acinar-to-ductal metaplasia and pancreatic cancer cells
Oncotarget. 2015 Dec 22. doi: 10.18632/oncotarget.6717. [Epub ahead of print]
Kong B, Cheng T, Qian C, Wu W, Steiger K, Cao J, Schlitter AM, Regel I, Raulefs S, Friess H, Erkan M, Esposito I, Kleeff J, Michalski CW.
Pancreas-specific activation of mTOR and loss of p53 induce tumors reminiscent of acinar cell carcinoma
Mol Cancer. 2015 Dec 18;14(1):212. doi: 10.1186/s12943-015-0483-1
Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, Kato Y, Klimstra DS, Klöppel G, Krasinskas A, Longnecker DS, Matthaei H, Offerhaus GJ, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T.
A Revised Classification System and Recommendations From the Baltimore Consensus Meeting for Neoplastic Precursor Lesions in the Pancreas
Am J Surg Pathol. 2015 Dec;39(12):1730-41. doi: 10.1097/PAS.0000000000000533
Scholl UI, Healy JM, Thiel A, Fonseca AL, Brown TC, Kunstman JW, Horne MJ, Dietrich D, Riemer J, Kücükköylü S, Reimer EN, Reis AC, Goh G, Kristiansen G, Mahajan A, Korah R, Lifton RP, Prasad ML, Carling T.
Novel somatic mutations in primary hyperaldosteronism are related to the clinical, radiological and pathological phenotype
Clin Endocrinol (Oxf). 2015 Dec;83(6):779-89. doi: 10.1111/cen.12873. Epub 2015 Sep 23.
Borowski A, Heikaus S, Kurt M.
Calcium Pyrophosphate Dihydrate Crystal Deposition Disease
of the Sternoclavicular Joint

Thorac Cardiovasc Surg Rep. 2015 Dec;4(1):46-8. doi: 10.1055/s-0034-1390153.
Epub 2014 Oct 31.
Esposito I, Segler A, Steiger K, Klöppel G.
Pathology, genetics and precursors of human and experimental pancreatic neoplasms: An update
Pancreatology. 2015 Nov-Dec;15(6):598-610. doi: 10.1016/j.pan.2015.08.007. Epub 2015 Sep 3
Nitsche U, Wenzel P, Siveke JT, Braren R, Holzapfel K, Schlitter AM, Stöß C,
Kong B, Esposito I, Erkan M, Michalski CW, Friess H, Kleeff J
Resectability After First-Line FOLFIRINOX in Initially Unresectable Locally Advanced Pancreatic Cancer: A Single-Center Experience
Ann Surg Oncol. 2015 Dec;22 Suppl 3:1212-20. doi: 10.1245/s10434-015-4851-2.
Published: DEC 2015
Weber J, Öllinger R, Friedrich M, Ehmer U, Barenboim M, Steiger K, Heid I, Mueller S, Maresch R, Engleitner T, Gross N, Geumann U, Fu B, Segler A, Yuan D, Lange S, Strong A, de la Rosa J, Esposito I, Liu P, Cadiñanos J, Vassiliou GS, Schmid RM, Schneider G, Unger K, Yang F, Braren R, Heikenwälder M, Varela I, Saur D, Bradley A, Rad R.
CRISPR/Cas9 somatic multiplex-mutagenesis for high-throughput
functional cancer genomics in mice

Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):13982-7.
doi: 10.1073/pnas.1512392112. Epub 2015 Oct 27.
Bhatia S, Reister S, Mahotka C, Meisel R, Borkhardt A, Grinstein E.
Control of AC133/CD133 and impact on human hematopoietic progenitor cells through nucleolin
Leukemia. 2015 Nov;29(11):2208-20. doi: 10.1038/leu.2015.146. Epub 2015 Jun 19.
Arsov C, Becker N, Rabenalt R, Hiester A, Quentin M, Dietzel F, Antoch G, Gabbert HE, Albers P, Schimmöller L.
The use of targeted MR-guided prostate biopsy reduces the risk of Gleason upgrading on radical prostatectomy
J Cancer Res Clin Oncol. 2015 Nov;141(11):2061-8. doi: 10.1007/s00432-015-1991-5.
Epub 2015 May 27.
Hilal Z, Tempfer C, Schiermeier S, Reinecke J, Ruppenkamp C.
Progression or Regression? - Strengths and Weaknesses
of the New Munich Nomenclature III for Cervix Cytology
Geburtshilfe Frauenheilkd. 2015 Oct;75(10):1051-1057
Hilal Z, Tempfer C, Schiermeier S, Reinecke J, Ruppenkamp C, Hilal Z.
Progression or Regression? - Strengths and Weaknesses
of the New Munich Nomenclature III for Cervix Cytology
Geburtshilfe Frauenheilkd. 2015 Oct;75(10):1051-1057
Carosati E, van den Höfel N, Reif M, Randazzo GM, Stanitzki B, Stevens J, Gabbert HE, Cruciani G, Mannhold R, Mahotka C.
Discovery of Novel, Potent, and Specific Cell-Death Inducers in the Jurkat Acute Lymphoblastic Leukemia Cell Line
ChemMedChem. 2015 Oct;10(10):1700-6. doi: 10.1002/cmdc.201500245.
Epub 2015 Aug 12.
Mersch S, Riemer JC, Schlünder PM, Ghadimi MP, Ashmawy H, Möhlendick B, Topp SA, Arent T, Kröpil P, Stoecklein NH, Gabbert HE, Knoefel WT, Krieg A.
Peritoneal sarcomatosis: site of origin for the establishment
of an in vitro and in vivo cell line model to study therapeutic resistance in dedifferentiated liposarcoma

Tumour Biol. 2015 Sep 15. [Epub ahead of print]
Schemenau J, Baldus S, Anlauf M, Reinecke P, Braunstein S, Blum S, Nachtkamp K, Neukirchen J, Strup C, Aul C, Haas R, Gattermann N, Germing U.
Cellularity, characteristics of hematopoietic parameters
and prognosis in myelodysplastic syndromes

Eur J Haematol. 2015 Sep;95(3):181-9. doi: 10.1111/ejh.12512. Epub 2015 May 15
Kraus S; Vay C; Baldus S; Knoefel WT; Stoecklein NH; Vallbohmer D
Expression of wingless-type mouse mammary tumor virus integration
site family pathway effectors in lymphatic and hepatic metastases of patients with colorectal cancer: Associations with the primary tumor

Oncology Letters. 2015 Aug.10(2):863-868. DOI: 10.3892/ol.2015.3291
Deml KF, Schildhaus HU, Compérat E, von Teichman A, Storz M, Schraml P, Bonventre JV, Fend F, Fleige B, Nerlich A, Gabbert HE, GaBler N, Grobholz R, Hailemariam S, Hinze R, Knüchel R, Lhermitte B, Nesi G, Rüdiger T, Sauter G, Moch H.
Clear cell papillary renal cell carcinoma and renal angiomyoadenomatous tumor: two variants of a morphologic, immunohistochemical, and genetic distinct entity of renal cell carcinoma
Am J Surg Pathol. 2015 Jul;39(7):889-901. doi: 10.1097/PAS.0000000000000456
Krieg A, Riemer JC, Telan LA, Gabbert HE, Knoefel WT.
CXCR4--A Prognostic and Clinicopathological Biomarker for Pancreatic Ductal Adenocarcinoma: A Meta-Analysis
PLoS One. 2015 Jun 19;10(6):e0130192. doi: 10.1371/journal.pone.0130192. eCollection 2015
Anlauf M1, Neumann M, Bomberg S, Luczak K, Heikaus S, Gustmann C, Antke C, Ezziddin S, Fottner C, Pavel M, Pape UF, Rinke A, Lahner H, Schott M, Cremer B, Hörsch D, Baum RP, Groh U, Alkatout I, Rudlowski C, Scheler P, Zirbes TK, Hoffmann J, Fehm T, Gabbert HE, Baldus SE.
Neuroendocrine neoplasms of the breast
Pathologe. 2015 May;36(3):261-70. doi: 10.1007/s00292-015-0024-0.
Koliaki C, Szendroedi J, Kaul K, Jelenik T, Nowotny P, Jankowiak F, Herder C, Carstensen M, Krausch M, Knoefel WT, Schlensak M, Roden M
Adaptation of hepatic mitochondrial function in humans with non-alcoholic Fatty liver is lost in steatohepatitis
Cell Metab. 2015 May 5;21(5):739-46. doi: 10.1016/j.cmet.2015.04.004.
Anlauf M, Neumann M, Bomberg S, Luczak K, Heikaus S, Gustmann C, Antke C, Ezziddin S, Fottner C, Pavel M, Pape UF, Rinke A, Lahner H, Schott M, Cremer B, Hörsch D, Baum RP, Groh U, Alkatout I, Rudlowski C, Scheler P, Zirbes TK, Hoffmann J, Fehm T, Gabbert HE, Baldus SE.
Neuroendocrine neoplasms of the breast
Pathologe. 2015 May;36(3):261-70. doi: 10.1007/s00292-015-0024-0.
Schneitler S, Kröpil P, Riemer J, Antoch G, Knoefel WT, Häussinger D, Graf D.
Metastasized pancreatic carcinoma with neoadjuvant
FOLFIRINOX therapy and R0 resection

World J Gastroenterol. 2015 May 28;21(20):6384-90.
doi: 10.3748/wjg.v21.i20.6384.
Weis B, Schmidt J, Maamar H, Raj A, Lin H, Tóth C, Riedmann K, Raddatz G,
Seitz HK, Ho AD, Lyko F, Linhart HG.
Inhibition of intestinal tumor formation by deletion of the DNA methyltransferase 3a
Oncogene. 2015 Apr 2;34(14):1822-30. doi: 10.1038/onc.2014.114.
Epub 2014 May 19.
Dueppers P, Jankowiak S, Schelzig H, Wagenhäuser MU, Oberhuber A.
Spontaneous rupture of an isolated iliac artery dissection in a young man because of cystic medial degeneration Erdheim-Gsell
Ann Vasc Surg. 2015 Apr;29(3):596.e11-3. doi: 10.1016/j.avsg.2014.10.041.
Epub 2015 Jan 14.
Reis H1, Wohlschläger J, Hagemann S, Wenzel P, Bechmann LP, Suttorp AC, Schlattjan MJ, Herzer K, Canbay A, Baba HA.
(Cleaved) CK18 serum and tissue expression levels differentiate acute HCV reinfection from acute rejection in liver allografts
Liver Int. 2015 Mar;35(3):905-13. doi: 10.1111/liv.12572. Epub 2014 May 12.
Juhlin CC, Goh G, Healy JM, Fonseca AL, Scholl UI, Stenman A, Kunstman JW, Brown TC, Overton JD, Mane SM, Nelson-Williams C, Bäckdahl M, Suttorp AC, Haase M, Choi M, Schlessinger J, Rimm DL, Höög A, Prasad ML, Korah R, Larsson C, Lifton RP, Carling T.
Whole-exome sequencing characterizes the landscape of somatic mutations and copy number alterations in adrenocortical carcinoma
J Clin Endocrinol Metab. 2015 Mar;100(3):E493-502. doi: 10.1210/jc.2014-3282.
Epub 2014 Dec 9
Borrelli M, Joepen N, Reichl S, Finis D, Schoppe M, Geerling G, Schrader S.
Keratin films for ocular surface reconstruction:
evaluation of biocompatibility in an in-vivo model

Biomaterials. 2015 Feb;42:112-20.
doi: 10.1016/j.biomaterials.2014.11.038. Epub 2014 Dec 16.
Alkatout I, Friemel J, Sitek B, Anlauf M, Eisenach PA, Stühler K, Scarpa A, Perren A, Meyer HE, Knoefel WT, Klöppel G, Sipos B.
Novel prognostic markers revealed by a proteomic approach separating
benign from malignant insulinomas

Mod Pathol. 2015 Jan;28(1):69-79. doi: 10.1038/modpathol.2014.82.
Epub 2014 Jun 20.
Verburg FA; Anlauf M; Mottaghy FM; Karges W  
Somatostatin Receptor Imaging-Guided Pasireotide Therapy in Medullary Thyroid Cancer With Ectopic Adrenocorticotropin Production
CLINICAL NUCLEAR MEDICINE 2015 Jan;40(1):E83-E84

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