Stress-related mechanisms

Several research strategies are realized in order to explain psychobiological mechanisms linking ERI-induced stressful experience with adverse health outcomes. These research strategies include ambulatory monitoring in naturalistic settings, experimental studies and analyses of innovative biomedical markers in high risk groups identified in the context of epidemiological studies. Selected recent publications include:

Almadi T, Cathers I, Mansour AMH et al (2012) The association netween work stress and inflammatory biomarkers in Jordanian male workers. Psychophysiology 49: 172-177.

Bathman LM, Almond J, Hazi A, Wright BJ: Effort–reward imbalance at work and pre-clinical biological indices of ill-health: The case for salivary immunoglobulin A. Brain, Behavior, and Immunity.

Bellingrath S, Rohleder N, Kudielka BM (2013) Effort-reward imbalance in healthy teachers is associated with higher LPS-stimulated production and lower glucocorticoid sensitivity of interleukin-6 in vitro. Biol Psychol 92: 403-409.

Bellingrath, S. and Kudielka, B. (2008). Effort-reward-imbalance and overcommitment are associated with hypothalamus-putuitary-adrenal (HPA) axis responses to acute psychosocial stress in healthy working schoolteachers. Psychoneuroendocrinology, 33, 1335-1343, doi: 10.1016/j.psyneuen.2008.07.008 .

Bellingrath, S., Rohleder, N. and Kudielka, B. M. (2010). Healthy working school teachers with high effort-reward-imbalance and overcommitment show increased pro-inflammatory immune activity and a dampened innate immune defence. Brain, Behavior, and Immunity, 24 (8), 1332-1339, doi: 10.1016/j.bbi.2010.06.011, URL

Bellingrath, S., Weigl, T. and Kudielka, B. (2007). Chornic work stress and exhaustion is associated with higher allostatic load in female school teachers. Stress: The International Journal on the Biology of Stress, 12, 37-48.

Bellingrath, S., Weigl, T. and Kudielka, B. (2008). Cortisol dysregulation in school teachers in relation to burnout, vital exhaustion, and effort-reward imbalance. Biological Psychology, 78, 104-113, doi: 10.1016/j.biopsycho.2008.01.006.

Bosch, J., Fischer, J. and Fischer, J. (2009). Psychologically adverse work conditions are associated with CD8+ T cell differentiation indicative of immunesenescence. Brain, Behavior, and Immunity, 23, 527-534, doi: 10.1016/j.bbi.2009.02.002 .

Eller, N. H., Kristiansen, J. and Hansen, Å. M. (2011). Long-term effects of psychosocial factors of home and work on biomarkers of stress. International Journal of Psychophysiology, 79 (2), 195-202, doi: 10.1016/j.ijpsycho.2010.10.009,  URL

Eller, N. H., Nielsen, S. F., Blønd, M., Nielsen, M. L., Hansen, Å. M. and Netterstrøm, B. (2012). Effort reward imbalance, and salivary cortisol in the morning. Biological Psychology, 89 (2), 342-348, doi: 10.1016/j.biopsycho.2011.11.007,  URL

Fischer, J., Kudielka, B., von Kanel, R., Siegrist, J., Thayer, J. and Fischer, J. (2009). Bone-narrow derived progenitor cells are associated with psychosocial determinants of health after controlling for classical biological and behavioural cardiovascular risk factors. Brain, Behavior, and Immunity, 23 (4), 419-426.

Hamer, M., Williams, E., Vuonovirta, R., Giacobazzi, P. et al. (2006). The effects of effort-reward imbalance on inflammatory and cardiovascular responses to mental stress. Psychosomatic Medicine, 68, 408-413.

Hansen, A., Larsen, A., Rugulies, R., Garde, A. and Knudsen, L. (2009). A review of the effect of the psychosocial working environment on physiological changes in blood and urine. Basic & Clinical Pharmacology & Toxicology, 105 (73-83), 73-83, doi: 10.1111/j.1742-7843.2009.00444.x  .

Hintsanen, M., Elovainio, M., Puttonen, S., Kivimäki, M., Koskinen, T., Raitakari, O. and Keltikangas-Järvinen, L. (2007). Effort-reward imbalance, heart rate, and heart rate variability: the cardiovascular risk in young finns study. International Journal of Behavioral Medicine, 14, 202-212, doi: 10.1007/BF03002994  .

Inoue, A., Kawakami, N., Ishizaki, M., Tabata, M., Tsuchiya, M. et al. (2009). Three job stress models/concepts and oxidative DNA damage in a sample of workers in Japan. Journal of Psychosomatic Research, 66, 329-334, doi: 10.1016/j.jpsychores.2008.09.016  .

Jarczok MN, Jarczok M, Mauss D et al (2013) Autonomic nervous system activity and workplace stressors- A systematic review. Neuroscience and Biobehavioral Reviews 37: 1810-1823.

Kanel, R., Bellingrath, S. and Kudielka, B. (2009). Overcommitment but not effort-reward imbalance relates to stress-induced coagulation changes in teachers. Annals of Behavioral Medicine, 37, 20-28, doi: 10.1007/s12160-009-9082-y  .

Liao J, Brunner EJ, Kumari M (2013): Is there an association between work stress and diurnal cortisol patterns? Findings from the Whitehall II study. PLoS One 8;12:e81020.

Loerbroks, A., Schilling, O., Haxsen, V., Jarczok, M. N., Thayer, J. F. and Fischer, J. E. (2010). The fruit of ones labor: Effort-reward imbalance but not job strain is related to heart rate variability across the day in 34-44-year-old workers. Journal of Psychosomatic Research, 69, 151-159, doi: 10.1016/j.jpsychores.2010.03.004,  URL

Maina, G., Bovenzi, M., Palmas, A. and Larese, F. (2009). Associations between two job stress models and measures of salivary cortisol. International Archives of Occupational and Environmental Health, 89 (9), 1141-1150, doi: 10.1007/s00420-009-0439-0  .

Nakata A, Takahashi M, Irie M (2011) Effort-reward imbalance, overcommitment, and cellular immune measures among white-collar empüloyees. Biol Psychol 88: 270-279.

Siegrist, J. (2005). Social reciprocity and health: New scientific evidence and policy implications. Psychoneuroendocrinology, 30 (10), 1033-1038, doi: 10.1016/j.psyneuen.2005.03.017  .

Siegrist, J., Menrath, I., Stöcker, T., Klein, M. et al. (2005). Differential brain activation according to chronic social reward frustration. NeuroReport, 16, 1899-1903.

Steptoe, A., Siegrist, J., Kirschbaum, C. and Marmot, M. (2004). Effort-reward imbalance, overcommitment, and measures of cortisol and blood pressure over the working day. Psychosomatic Medicine, 66, 1899-1903.

Vrijkotte, T., van Doornen, L. and de Geus, E. (1999). Work stress and metabolic and hemostatic risk factors. Psychosomatic Medicine, 61, 796-805.

Vrijkotte, T., van Doornen, L. and de Geus, E. (2000). Effects of work stress of ambulatory blood pressure, heart rate, and heart rate variability. Hypertension, 35 (4), 880.

Wirtz, P., Siegrist, J., Rimmele, U. and Ehlert, U. (2008). Higher overcommitment to work is associated with lower norepinephrine secretions before and after acute psychosocial stress in men. Psychoneuroendocrinology, 33, 92-99.

Wright, B. J. (2011). Effort-Reward Imbalance Is Associated With Salivary Immunoglobulin A and Cortisol Secretion in Disability Workers. Journal of Occupational & Environmental Medicine, 53, 308-312, doi: 10.1097/JOM.0b013e31820c90b7

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