Publications
Publications 2024
Burkitt B Cell Lymphoma.
Weber F, Weber A, Schmitt L, Lechtenberg I, Greb J, Henßen B, Wesselborg S, Pietruszka J.Chemistry. 2024 Feb 27:e202400559. doi: 10.1002/chem.202400559. Online ahead of print.PMID: 38411573
Novel meriolin derivatives activate the mitochondrial apoptosis pathway in the presence of antiapoptotic Bcl-2
Schmitt L, Lechtenberg I, Drießen D, Flores-Romero H, Skowron M, Sekeres M, Hoppe J, Krings K, Llewellyn T, Peter C, Stork B, Qin N, Bhatia S, Nettersheim D, Fritz G, García-Sáez A, Müller T and Wesselborg S. Cell Death Discov. 2024 Mar 9;10(1):125. doi: 10.1038/s41420-024-01901-y
Publications 2023
Vaccine-induced SARS-CoV-2 antibody response: the comparability of S1-specific binding assays depends on epitope and isotype discrimination.
Schest S, Langer C, Stiegler Y, Karnuth B, Arends J, Stiegler H, Masetto T, Peter C, Grimmler M. Front Immunol. 2023 Oct 26;14:1257265. doi: 10.3389/fimmu.2023.1257265. eCollection 2023. PMID: 37965324
The Impact of p70S6 Kinase-Dependent Phosphorylation of Gemin2 in UsnRNP Biogenesis.
Esser LM, Li Q, Jüdt M, Kähne T, Stork B, Grimmler M, Wesselborg S, Peter C. Int J Mol Sci. 2023 Oct 25;24(21):15552. doi: 10.3390/ijms242115552. PMID: 37958537
Comprehensive Comparison of the Capacity of Functionalized Sepharose, Magnetic Core, and Polystyrene Nanoparticles to Immuno-Precipitate Procalcitonin from Human Material for the Subsequent Quantification by LC-MS/MS.
Masetto T, Matzenbach K, Reuschel T, Tölke SA, Schneider K, Esser LM, Reinhart M, Bindila L, Peter C, Grimmler M. Int J Mol Sci. 2023 Jun 30;24(13):10963. doi: 10.3390/ijms241310963. PMID: 37446139
Characterization of Native COMPASS Complex in Urothelial Carcinoma Cells by Size Exclusion Chromatography.
Peter C, Schulz WA, Whongsiri P. Methods Mol Biol. 2023;2684:101-109. doi: 10.1007/978-1-0716-3291-8_5. PMID: 37410229
Phosphorylation of pICln by the autophagy activating kinase ULK1 regulates snRNP biogenesis and splice activity of the cell.
Esser LM, Schmitz K, Hillebrand F, Erkelenz S, Schaal H, Stork B, Grimmler M, Wesselborg S, Peter C. Comput Struct Biotechnol J. 2023 Mar 16;21:2100-2109. doi: 10.1016/j.csbj.2023.03.015. eCollection 2023. PMID: 36968021 Free PMC article.
Bioinformatical Design and Performance Evaluation of a Nucleocapsid- and an RBD-Based Particle Enhanced Turbidimetric Immunoassay (PETIA) to Quantify the Wild Type and Variants of Concern-Derived Immunoreactivity of SARS-CoV-2.
Wey L, Masetto T, Spaeth A, Brehm J, Kochem C, Reinhart M, Müller H, Kempin U, Lorenz F, Peter C, Grimmler M.Biomedicines. 2023 Jan 8;11(1):160. doi: 10.3390/biomedicines11010160.PMID: 36672668
Publications 2022
Cardiac injection of USSC boosts remuscularization of the infarcted heart by shaping the T-cell response.
Ding Z, Tan K, Alter C, Temme S, Bouvain P, Owenier C, Hänsch S, Wesselborg S, Peter C, Weidtkamp-Peters S, Flögel U, Schira-Heinen J, Stühler K, Hesse J, Kögler G, Schrader J. J Mol Cell Cardiol. 2022 Dec 6:S0022-2828(22)00566-1. doi: 10.1016/j.yjmcc.2022.11.006.
The mycotoxin viriditoxin induces leukemia- and lymphoma-specific apoptosis by targeting mitochondrial metabolism.
Stuhldreier F, Schmitt L, Lenz T, Hinxlage I, Zimmermann M, Wollnitzke P, Schliehe-Diecks J, Liu Y, Jäger P, Geyh S, Teusch N, Peter C, Bhatia S, Haas R, Levkau B, Reichert A, Stühler K, Proksch P, Stork B, Wesselborg S. Cell Death Dis 2022 Nov 8; volume 13, Article number: 938 (2022); PMID: 36347842 PMCID: PMC9643474 DOI: 10.1038/s41419-022-05356-w
Development of Macrocyclic PRMT5-Adaptor Protein Interaction Inhibitors.
Krzyzanowski A, Esser LM, Willaume A, Prudent R, Peter C, 't Hart P, Waldmann H. J Med Chem. 2022 Nov 15. doi: 10.1021/acs.jmedchem.2c01273. Online ahead of print.PMID: 36378254
SARS-CoV-2 antibody progression and neutralizing potential in mild symptomatic COVID-19 patients - a comparative long term post-infection study.
Brehm J, Spaeth A, Dreßler L, Masetto T, Dannenberg R, Peter C, Grimmler M. Front Immunol. 2022 Aug 17;13:915338. doi: 10.3389/fimmu.2022.915338. eCollection 2022
NF90/NFAR (nuclear factors associated with dsRNA) - a new methylation substrate of the PRMT5-WD45-RioK1 complex.
Cox J, Esser L M, Judt M, Schmitz K, Reiffert K, Grimmler M, Stork B, Wesselborg S & Peter C. Biol Chem. 2022, doi.org/10.1515/hsz-2022-0136
National External Quality Assessment and direct method comparison reflect crucial deviations of Procalcitonin measurements in Germany.
Masetto T, Eidizadeh A, Peter C, Grimmler M. Clin Chim Acta. 2022 Feb 12:S0009-8981(22)00057-2. doi: 10.1016/j.cca.2022.02.007. Online ahead of print. PMID: 35167843
Publications 2021
Characterization of the Diagnostic Performance of a Novel COVID-19 PETIA in Comparison to Four Routine N-, S- and RBD-Antigen Based Immunoassays.
Spaeth A, Masetto Th, Brehm J, Wey L, Kochem Ch, Brehm M, Peter C and Grimmler M. Diagnostics. 2021, 11(8). https://doi.org/10.3390/diagnostics11081332
TNF-induced necroptosis initiates early autophagy events via RIPK3-dependent AMPK activation, but inhibits late autophagy.
Wu W, Wang X, Sun Y, Berleth N, Deitersen J, Schlütermann D, Stuhldreier F, Wallot-Hieke N, José Mendiburo M, Cox J, Peter C, Bergmann AK, Stork B. Autophagy. 2021 Dec;17(12):3992-4009. doi: 10.1080/15548627.2021.1899667. Epub 2021 Mar 28. PMID: 33779513
Fin56-induced ferroptosis is supported by autophagy-mediated GPX4 degradation and functions synergistically with mTOR inhibition to kill bladder cancer cells.
Sun Y, Berleth N, Wu W, Schlütermann D, Deitersen J, Stuhldreier F, Berning L, Friedrich A, Akgün S, Mendiburo MJ, Wesselborg S, Conrad M, Berndt C, Stork B. Cell Death Dis. 2021 Oct 29;12(11):1028. doi: 10.1038/s41419-021-04306-2. PMID: 34716292
ULK1 phosphorylation of striatin activates protein phosphatase 2A and autophagy.
Hu Z, Sankar DS, Vu B, Leytens A, Vionnet C, Wu W, Stumpe M, Martínez-Martínez E, Stork B, Dengjel J. Cell Rep. 2021 Sep 28;36(13):109762. doi: 10.1016/j.celrep.2021.109762. PMID: 3459214
FIP200 controls the TBK1 activation threshold at SQSTM1/p62-positive condensates.
Schlütermann D, Berleth N, Deitersen J, Wallot-Hieke N, Friesen O, Wu W, Stuhldreier F, Sun Y, Berning L, Friedrich A, Mendiburo MJ, Peter C, Wiek C, Hanenberg H, Stefanski A, Stühler K, Stork B.Sci Rep. 2021 Jul 5;11(1):13863. doi: 10.1038/s41598-021-92408-4.PMID: 34226595
An essential role of the autophagy activating kinase ULK1 in snRNP biogenesis.
Schmitz K, Cox J, Esser LM, Voss M, Sander K, Löffler A, Hillebrand F, Erkelenz S, Schaal H, Kähne T, Klinker S, Zhang T, Nagel-Steger L, Willbold D, Seggewiß S, Schlütermann D, Stork B, Grimmler M, Wesselborg S, Peter C. Nucleic Acids Res. 2021 Jun 21;49(11):6437-6455. doi: 10.1093/nar/gkab452
Phosphorylation of GAPVD1 Is Regulated by the PER Complex and Linked to GAPVD1 Degradation.
Ibrahim H, Reus P, Mundorf AK, Grothoff AL, Rudenko V, Buschhaus C, Stefanski A, Berleth N, Stork B, Stühler K, Kalfalah F, Reinke H. Int J Mol Sci. 2021 Apr 6;22(7):3787. doi: 10.3390/ijms22073787. PMID: 33917494
40 Years of Research on Polybrominated Diphenyl Ethers (PBDEs)-A Historical Overview and Newest Data of a Promising Anticancer Drug.
Schmitt L, Hinxlage I, Cea P, Gohlke H, Wesselborg S. Molecules. 2021 Feb 13;26(4):995. doi: 10.3390/molecules26040995
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.
Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, et. al. Autophagy. 2021 Jan;17(1):1-382. doi: 10.1080/15548627.2020.1797280. Epub 2021 Feb 8. PMID: 33634751
Dithiodiketopiperazine derivatives from endophytic fungi Trichoderma harzianum and Epicoccum nigrum.
Harwoko H, Daletos G, Stuhldreier F, Lee J, Wesselborg S, Feldbrügge M, Müller WEG, Kalscheuer R, Ancheeva E, Proksch P. Nat Prod Res. 2021 Jan;35(2):257-265. doi: 10.1080/14786419.2019.1627348. Epub 2019 Jun 18
Publications 2020
Induction of New Lactam Derivatives From the Endophytic Fungus Aplosporella javeedii Through an OSMAC Approach.
Gao Y, Stuhldreier F, Schmitt L, Wesselborg S, Guo Z, Zou K, Mándi A, Kurtán T, Liu Z, Proksch P. Front Microbiol. 2020 Nov 4;11:600983. doi: 10.3389/fmicb.2020.600983. eCollection 2020. PMID: 33250887
The phospho-barcode of RIPK1: complementarity or redundancy?
Wu W, Stork B. Mol Cell Oncol. 2020 Jul 16;7(5):1776085. doi: 10.1080/23723556.2020.1776085. eCollection 2020. PMID: 32944633
Sesterterpenes and macrolide derivatives from the endophytic fungus Aplosporella javeedii.
Gao Y, Stuhldreier F, Schmitt L, Wesselborg S, Wang L, Müller WEG, Kalscheuer R, Guo Z, Zou K, Liu Z, Proksch P.Fitoterapia. 2020 Oct;146:104652. doi: 10.1016/j.fitote.2020.104652. Epub 2020 Jun 6.PMID: 32512149
Carbamoyl-Phosphate Synthase 1 as a Novel Target of Phomoxanthone A, a Bioactive Fungal Metabolite.
Ceccacci S, Deitersen J, Mozzicafreddo M, Morretta E, Proksch P, Wesselborg S, Stork B, Monti MC.Biomolecules. 2020 Jun 2;10(6):846. doi: 10.3390/biom10060846.PMID: 32498414
The Autophagy-Initiating Kinase ULK1 Controls RIPK1-Mediated Cell Death.
Wu W, Wang X, Berleth N, Deitersen J, Wallot-Hieke N, Böhler P, Schlütermann D, Stuhldreier F, Cox J, Schmitz K, Seggewiß S, Peter C, Kasof G, Stefanski A, Stühler K, Tschapek A, Gödecke A, Stork B. Cell Rep. 2020 Apr 21;31(3):107547. doi: 10.1016/j.celrep.2020.107547. PMID: 32320653
Publications 2019
First Results from a Screening of 300 Naturally Occurring Compounds: 4,6-dibromo-2-(2',4'-dibromophenoxy)phenol, 4,5,6-tribromo-2-(2',4'-dibromophenoxy)phenol, and 5-epi-nakijinone Q as Substances with the Potential for Anticancer Therapy.
Mayer S, Prechtl M, Liebfried P, Cadeddu RP, Stuhldreier F, Kohl M, Wenzel F, Stork B, Wesselborg S, Proksch P, Germing U, Haas R, Jäger P. Mar Drugs. 2019 Sep 5;17(9):521. doi: 10.3390/md17090521. PMID: 31491907
Anthraquinones and autophagy - Three rings to rule them all?
Deitersen J, El-Kashef DH, Proksch P, Stork B. Bioorg Med Chem. 2019 Oct 15;27(20):115042. doi: 10.1016/j.bmc.2019.115042. Epub 2019 Aug 8. PMID: 31420258
Azaphilone pigments and macrodiolides from the coprophilous fungus Coniella fragariae.
Yu H, Sperlich J, Höfert SP, Janiak C, Teusch N, Stuhldreier F, Wesselborg S, Wang C, Kassack MU, Dai H, Liu Z, Proksch P. Fitoterapia. 2019 Sep;137:104249. doi: 10.1016/j.fitote.2019.104249. Epub 2019 Jun 25. PMID: 31247219
Novel meriolin derivatives as rapid apoptosis inducers.
Drießen D, Stuhldreier F, Frank A, Stark H, Wesselborg S, Stork B, Müller Th. Bioorg Med Chem. 2019 Aug 1;27(15):3463-3468. doi: 10.1016/j.bmc.2019.06.029. Epub 2019 Jun 19
Publications 2018
Multiple DNA damage-dependent and DNA damage-independent stress responses define the outcome of ATR/Chk1 targeting in medulloblastoma cells.
Krüger K, Geist K, Stuhldreier F, Schumacher L, Blümel L, Remke M, Wesselborg S, Stork B, Klöcker N, Bormann S, Roos WP, Honnen S, Fritz G. Cancer Lett. 2018 Aug 28;430:34-46. doi: 10.1016/j.canlet.2018.05.011. Epub 2018 May 16. PMID: 29753759
The mycotoxin phomoxanthone A disturbs the form and function of the inner mitochondrial membrane.
Böhler P, Stuhldreier F, Anand R, Kondadi AK, Schlütermann D, Berleth N, Deitersen J, Wallot-Hieke N, Wu W, Frank M, Niemann H, Wesbuer E, Barbian A, Luyten T, Parys JB, Weidtkamp-Peters S, Borchardt A, Reichert AS, Peña-Blanco A, García-Sáez AJ, Itskanov S, van der Bliek AM, Proksch P, Wesselborg S, Stork B. Cell Death Dis. 2018 Feb 19;9(3):286. doi: 10.1038/s41419-018-0312-8. PMID: 29459714
EBV Negative Lymphoma and Autoimmune Lymphoproliferative Syndrome Like Phenotype Extend the Clinical Spectrum of Primary Immunodeficiency Caused by STK4 Deficiency.
Schipp C, Schlütermann D, Hönscheid A, Nabhani S, Höll J, Oommen PT, Ginzel S, Fleckenstein B, Stork B, Borkhardt A, Stepensky P, Fischer U. Front Immunol. 2018 Oct 16;9:2400. doi: 10.3389/fimmu.2018.02400. eCollection 2018. PMID: 30386345
Correction: SIRT4 interacts with OPA1 and regulates mitochondrial quality control and mitophagy.
Lang A, Anand R, Altinoluk-Hambüchen S, Ezzahoini H, Stefanski A, Iram A, Bergmann L, Urbach J, Böhler P, Hänsel J, Franke M, Stühler K, Krutmann J, Scheller J, Stork B, Reichert AS, Piekorz RP. Aging (Albany NY). 2018 Sep 28;10(9):2536. doi: 10.18632/aging.101570. No abstract available. PMID: 30300139
Targeting colorectal cancer cell metabolism through development of cisplatin and metformin nano-cubosomes.
Saber MM, Al-Mahallawi AM, Nassar NN, Stork B, Shouman SA. MC Cancer. 2018 Aug 15;18(1):822. doi: 10.1186/s12885-018-4727-5. PMID: 30111296
Adenosine enhances cisplatin sensitivity in human ovarian cancer cells.
Sureechatchaiyan P, Hamacher A, Brockmann N, Stork B, Kassack MU. Purinergic Signal. 2018 Dec;14(4):395-408. doi: 10.1007/s11302-018-9622-7. Epub 2018 Aug 4. PMID: 30078088
The ciliary protein RPGRIP1L governs autophagy independently of its proteasome-regulating function at the ciliary base in mouse embryonic fibroblasts.
Struchtrup A, Wiegering A, Stork B, Rüther U, Gerhardt C. Autophagy. 2018;14(4):567-583. doi: 10.1080/15548627.2018.1429874. Epub 2018 Feb 21. PMID: 29372668
Targeting urothelial carcinoma cells by combining cisplatin with a specific inhibitor of the autophagy-inducing class III PtdIns3K complex.
Schlütermann D, Skowron MA, Berleth N, Böhler P, Deitersen J, Stuhldreier F, Wallot-Hieke N, Wu W, Peter C, Hoffmann MJ, Niegisch G, Stork B. Urol Oncol. 2018 Apr;36(4):160.e1-160.e13. doi: 10.1016/j.urolonc.2017.11.021. Epub 2017 Dec 21. PMID: 29276062
Systematic analysis of ATG13 domain requirements for autophagy induction.
Wallot-Hieke N, Verma N, Schlütermann D, Berleth N, Deitersen J, Böhler P, Stuhldreier F, Wu W, Seggewiß S, Peter C, Gohlke H, Mizushima N, Stork B. Autophagy. 2018;14(5):743-763. doi: 10.1080/15548627.2017.1387342. Epub 2018 Mar 21. PMID: 29173006
Publications 2017
Cyclic Cystine-Bridged Peptides from the Marine Sponge Clathria basilana Induce Apoptosis in Tumor Cells and Depolarize the Bacterial Cytoplasmic Membrane.
Mokhlesi A, Stuhldreier F, Wex KW, Berscheid A, Hartmann R, Rehberg N, Sureechatchaiyan P, Chaidir C, Kassack MU, Kalscheuer R, Brötz-Oesterhelt H, Wesselborg S, Stork B, Daletos G, Proksch P. J Nat Prod. 2017 Nov 22;80(11):2941-2952. doi: 10.1021/acs.jnatprod.7b00477. Epub 2017 Nov 2. PMID: 29094598
Serum α-1 Antitrypsin (AAT) antagonizes intrinsic apoptosis induction in neutrophils from patients with systemic inflammatory response syndrome.
Sarabhai T, Peter C, Bär AK, Windolf J, Relja B, Wesselborg S, Wahlers T, Paunel-Görgülü A. PLoS One. 2017 May 11;12(5):e0177450. doi: 10.1371/journal.pone.0177450. eCollection 2017. PMID: 28493974
SIRT4 interacts with OPA1 and regulates mitochondrial quality control and mitophagy.
Lang A, Anand R, Altinoluk-Hambüchen S, Ezzahoini H, Stefanski A, Iram A, Bergmann L, Urbach J, Böhler P, Hänsel J, Franke M, Stühler K, Krutmann J, Scheller J, Stork B, Reichert AS, Piekorz RP. Aging (Albany NY). 2017 Oct 29;9(10):2163-2189. doi: 10.18632/aging.101307. PMID: 29081403
Study of ULK1 Catalytic Activity and Its Regulation.
Stork B, Dengjel J. Methods Enzymol. 2017;587:391-404. doi: 10.1016/bs.mie.2016.09.067. Epub 2016 Nov 18. PMID: 28253968
Publications 2016
Efficient and safe gene delivery to human corneal endothelium using magnetic nanoparticles. Czugala M, Mykhaylyk O, Böhler P, Onderka J, Stork B, Wesselborg S, Kruse FE, Plank C, Singer BB, Fuchsluger TA. Nanomedicine (Lond). 2016 Jul;11(14):1787-800. doi: 10.2217/nnm-2016-0144. Epub 2016 Jul 7. PMID: 27388974
Staurosporine resistance in inflammatory neutrophils is associated with the inhibition of caspase- and proteasome-mediated Mcl-1 degradation.
Hornstein T, Lehmann S, Philipp D, Detmer S, Hoffmann M, Peter C, Wesselborg S, Unfried K, Windolf J, Flohé S, Paunel-Görgülü A. J Leukoc Biol. 2016 Jan;99(1):163-74. doi: 10.1189/jlb.3A1114-537RR. Epub 2015 Aug 26. PMID: 26310832
A systems study reveals concurrent activation of AMPK and mTOR by amino acids.
Dalle Pezze P, Ruf S, Sonntag AG, Langelaar-Makkinje M, Hall P, Heberle AM, Razquin Navas P, van Eunen K, Tölle RC, Schwarz JJ, Wiese H, Warscheid B, Deitersen J, Stork B, Fäßler E, Schäuble S, Hahn U, Horvatovich P, Shanley DP, Thedieck K. Nat Commun. 2016 Nov 21;7:13254. doi: 10.1038/ncomms13254. PMID: 27869123
An siRNA screen for ATG protein depletion reveals the extent of the unconventional functions of the autophagy proteome in virus replication.
Mauthe M, Langereis M, Jung J, Zhou X, Jones A, Omta W, Tooze SA, Stork B, Paludan SR, Ahola T, Egan D, Behrends C, Mokry M, de Haan C, van Kuppeveld F, Reggiori F. J Cell Biol. 2016 Aug 29;214(5):619-35. doi: 10.1083/jcb.201602046. PMID: 27573464
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Klionsky DJ, et al. Autophagy. 2016;12(1):1-222. doi: 10.1080/15548627.2015.1100356. No abstract available. Erratum in: Autophagy. 2016;12(2):443. Selliez, Iban [corrected to Seiliez, Iban]. PMID: 26799652
Publications 2015
Autophagy signal transduction by ATG proteins: from hierarchies to networks.
Wesselborg S, Stork B. Cell Mol Life Sci. 2015 Dec;72(24):4721-57. doi: 10.1007/s00018-015-2034-8. Epub 2015 Sep 21. Review. PMID: 26390974
Platelets induce apoptosis via membrane-bound FasL.
Schleicher RI, Reichenbach F, Kraft P, Kumar A, Lescan M, Todt F, Göbel K, Hilgendorf I, Geisler T, Bauer A, Olbrich M, Schaller M, Wesselborg S, O'Reilly L, Meuth SG, Schulze-Osthoff K, Gawaz M, Li X, Kleinschnitz C, Edlich F, Langer HF. Blood. 2015 Sep 17;126(12):1483-93. doi: 10.1182/blood-2013-12-544445. Epub 2015 Jul 31. Erratum in: Blood. 2016 Jan 14;127(2):270. PMID: 26232171
Expression of a ULK1/2 binding-deficient ATG13 variant can partially restore autophagic activity in ATG13-deficient cells.
Hieke N, Löffler AS, Kaizuka T, Berleth N, Böhler P, Drießen S, Stuhldreier F, Friesen O, Assani K, Schmitz K, Peter C, Diedrich B, Dengjel J, Holland P, Simonsen A, Wesselborg S, Mizushima N, Stork B. Autophagy. 2015;11(9):1471-83. doi: 10.1080/15548627.2015.1068488. PMID: 26213203
Deubiquitinase inhibition by WP1130 leads to ULK1 aggregation and blockade of autophagy.
Drießen S, Berleth N, Friesen O, Löffler AS, Böhler P, Hieke N, Stuhldreier F, Peter C, Schink KO, Schultz SW, Stenmark H, Holland P, Simonsen A, Wesselborg S, Stork B. Autophagy. 2015;11(9):1458-70. doi: 10.1080/15548627.2015.1067359. PMID: 26207339
Phomoxanthone A--From Mangrove Forests to Anticancer Therapy.
Frank M, Niemann H, Böhler P, Stork B, Wesselborg S, Lin W, Proksch P. Curr Med Chem. 2015;22(30):3523-32. Review.PMID: 26179997
Pleiotropic effects of spongean alkaloids on mechanisms of cell death, cell cycle progression and DNA damage response (DDR) of acute myeloid leukemia (AML) cells.
Stuhldreier F, Kassel S, Schumacher L, Wesselborg S, Proksch P, Fritz G. Cancer Lett. 2015 May 28;361(1):39-48. doi: 10.1016/j.canlet.2015.02.030. Epub 2015 Feb 16. PMID: 25697484
Publications 2014
ATG13: just a companion, or an executor of the autophagic program?
Alers S, Wesselborg S, Stork B. Autophagy. 2014 Jun;10(6):944-56. doi: 10.4161/auto.28987. Review. Erratum in: Autophagy. 2014 Aug;10(8):1481. PMID: 24879146
Callyspongiolide, a cytotoxic macrolide from the marine sponge Callyspongia sp.
Pham CD, Hartmann R, Böhler P, Stork B, Wesselborg S, Lin W, Lai D, Proksch P. Org Lett. 2014 Jan 3;16(1):266-9. doi: 10.1021/ol403241v. Epub 2013 Dec 13. PMID: 24329175
PDK1 controls upstream PI3K expression and PIP3 generation.
Dieterle AM, Böhler P, Keppeler H, Alers S, Berleth N, Drießen S, Hieke N, Pietkiewicz S, Löffler AS, Peter C, Gray A, Leslie NR, Shinohara H, Kurosaki T, Engelke M, Wienands J, Bonin M, Wesselborg S, Stork B. Oncogene. 2014 Jun 5;33(23):3043-53. doi: 10.1038/onc.2013.266. Epub 2013 Jul 29. PMID: 2389324
Publications 2013
Pro-apoptotic and immunostimulatory tetrahydroxanthone dimers from the endophytic fungus Phomopsis longicolla.
Rönsberg D, Debbab A, Mándi A, Vasylyeva V, Böhler P, Stork B, Engelke L, Hamacher A, Sawadogo R, Diederich M, Wray V, Lin W, Kassack MU, Janiak C, Scheu S, Wesselborg S, Kurtán T, Aly AH, Proksch P. J Org Chem. 2013 Dec 20;78(24):12409-25. doi: 10.1021/jo402066b. Epub 2013 Dec 11. PMID: 24295452
The p90 ribosomal S6 kinase (RSK) inhibitor BI-D1870 prevents gamma irradiation-induced apoptosis and mediates senescence via RSK- and p53-independent accumulation of p21WAF1/CIP1.
Neise D, Sohn D, Stefanski A, Goto H, Inagaki M, Wesselborg S, Budach W, Stühler K, Jänicke RU. Cell Death Dis. 2013 Oct 17;4:e859. doi: 10.1038/cddis.2013.386.PMID: 24136223
Milk fat globule-EGF factor 8 mediates the enhancement of apoptotic cell clearance by glucocorticoids.
Lauber K, Keppeler H, Munoz LE, Koppe U, Schröder K, Yamaguchi H, Krönke G, Uderhardt S, Wesselborg S, Belka C, Nagata S, Herrmann M. Cell Death Differ. 2013 Sep;20(9):1230-40. doi: 10.1038/cdd.2013.82. Epub 2013 Jul 5. PMID: 23832117
Vemurafenib potently induces endoplasmic reticulum stress-mediated apoptosis in BRAFV600E melanoma cells.
Beck D, Niessner H, Smalley KS, Flaherty K, Paraiso KH, Busch C, Sinnberg T, Vasseur S, Iovanna JL, Drießen S, Stork B, Wesselborg S, Schaller M, Biedermann T, Bauer J, Lasithiotakis K, Weide B, Eberle J, Schittek B, Schadendorf D, Garbe C, Kulms D, Meier F. Sci Signal. 2013 Jan 29;6(260):ra7. doi: 10.1126/scisignal.2003057. PMID: 23362240
The Dok-3/Grb2 protein signal module attenuates Lyn kinase-dependent activation of Syk kinase in B cell antigen receptor microclusters.
Lösing M, Goldbeck I, Manno B, Oellerich T, Schnyder T, Bohnenberger H, Stork B, Urlaub H, Batista FD, Wienands J, Engelke M. J Biol Chem. 2013 Jan 25;288(4):2303-13. doi: 10.1074/jbc.M112.406546. Epub 2012 Dec 5. PMID: 23223229
Publications 2012
Serum-derived plasminogen is activated by apoptotic cells and promotes their phagocytic clearance.
Rosenwald M, Koppe U, Keppeler H, Sauer G, Hennel R, Ernst A, Blume KE, Peter C, Herrmann M, Belka C, Schulze-Osthoff K, Wesselborg S, Lauber K. J Immunol. 2012 Dec 15;189(12):5722-8. doi: 10.4049/jimmunol.1200922. Epub 2012 Nov 12. PMID: 23150713
Release of lysophospholipid 'find-me' signals during apoptosis requires the ATP-binding cassette transporter A1.
Peter C, Waibel M, Keppeler H, Lehmann R, Xu G, Halama A, Adamski J, Schulze-Osthoff K, Wesselborg S, Lauber K. Autoimmunity. 2012 Dec;45(8):568-73. doi: 10.3109/08916934.2012.719947. Epub 2012 Sep 17. PMID: 22913458
The incredible ULKs.
Alers S, Löffler AS, Wesselborg S, Stork B. Cell Commun Signal. 2012 Mar 13;10(1):7. doi: 10.1186/1478-811X-10-7. PMID: 22413737
Cleavage of annexin A1 by ADAM10 during secondary necrosis generates a monocytic "find-me" signal.
Blume KE, Soeroes S, Keppeler H, Stevanovic S, Kretschmer D, Rautenberg M, Wesselborg S, Lauber K. J Immunol. 2012 Jan 1;188(1):135-45. doi: 10.4049/jimmunol.1004073. Epub 2011 Nov 23. PMID: 22116825
Role of AMPK-mTOR-Ulk1/2 in the regulation of autophagy: cross talk, shortcuts, and feedbacks.
Alers S, Löffler AS, Wesselborg S, Stork B. Mol Cell Biol. 2012 Jan;32(1):2-11. doi: 10.1128/MCB.06159-11. Epub 2011 Oct 24. Review. PMID: 22025673
Guidelines for the use and interpretation of assays for monitoring autophagy.
Klionsky DJ, et al. Autophagy. 2012 Apr;8(4):445-544. PMID: 22966490
Publications 2011
Atg13 and FIP200 act independently of Ulk1 and Ulk2 in autophagy induction.
Alers S, Löffler AS, Paasch F, Dieterle AM, Keppeler H, Lauber K, Campbell DG, Fehrenbacher B, Schaller M, Wesselborg S, Stork B. Autophagy. 2011 Dec;7(12):1423-33. PMID: 22024743
Triggering of a novel intrinsic apoptosis pathway by the kinase inhibitor staurosporine: activation of caspase-9 in the absence of Apaf-1.
Manns J, Daubrawa M, Driessen S, Paasch F, Hoffmann N, Löffler A, Lauber K, Dieterle A, Alers S, Iftner T, Schulze-Osthoff K, Stork B, Wesselborg S. FASEB J. 2011 Sep;25(9):3250-61. doi: 10.1096/fj.10-177527. Epub 2011 Jun 9. PMID: 21659556
Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop.
Löffler AS, Alers S, Dieterle AM, Keppeler H, Franz-Wachtel M, Kundu M, Campbell DG, Wesselborg S, Alessi DR, Stork B. Autophagy. 2011 Jul;7(7):696-706. Epub 2011 Jul 1. PMID: 21460634
Dual antitumour effect of 5-azacytidine by inducing a breakdown of resistance-mediating factors and epigenetic modulation.
Venturelli S, Berger A, Weiland T, Zimmermann M, Häcker S, Peter C, Wesselborg S, Königsrainer A, Weiss TS, Gregor M, Fulda S, Lauer UM, Bitzer M. Gut. 2011 Feb;60(2):156-65. doi: 10.1136/gut.2010.208041. Epub 2010 Nov 23. PMID: 21106551
Publications 2010
RioK1, a new interactor of protein arginine methyltransferase 5 (PRMT5), competes with pICln for binding and modulates PRMT5 complex composition and substrate specificity.
Guderian G, Peter C, Wiesner J, Sickmann A, Schulze-Osthoff K, Fischer U, Grimmler. J Biol Chem. 2011 Jan 21;286(3):1976-86. doi: 10.1074/jbc.M110.148486. Epub 2010 Nov 16. PMID: 21081503 Publications 2010
Apoptosis: opening PANdora's BoX.
Peter C, Wesselborg S, Lauber K. Curr Biol. 2010 Nov 9;20(21):R940-2. doi: 10.1016/j.cub.2010.09.066. Erratum in: Curr Biol. 2011 Jan 11;21(1):96. PMID: 21056838
Autoantibodies to muscarinic acetylcholine receptors found in patients with primary biliary cirrhosis.
Berg CP, Blume K, Lauber K, Gregor M, Berg PA, Wesselborg S, Stein GM. BMC Gastroenterol. 2010 Oct 16;10:120. doi: 10.1186/1471-230X-10-120. PMID: 20950485
Cutaneous papillomavirus E6 proteins must interact with p300 and block p53-mediated apoptosis for cellular immortalization and tumorigenesis.
Muench P, Probst S, Schuetz J, Leiprecht N, Busch M, Wesselborg S, Stubenrauch F, Iftner T. Cancer Res. 2010 Sep 1;70(17):6913-24. doi: 10.1158/0008-5472.CAN-10-1307. Epub 2010 Jul 27. PMID: 20663910
Dangerous attraction: phagocyte recruitment and danger signals of apoptotic and necrotic cells.
Peter C, Wesselborg S, Herrmann M, Lauber K. Apoptosis. 2010 Sep;15(9):1007-28. doi: 10.1007/s10495-010-0472-1. Review. PMID: 20157780
AMPK-independent induction of autophagy by cytosolic Ca2+ increase.
Grotemeier A, Alers S, Pfisterer SG, Paasch F, Daubrawa M, Dieterle A, Viollet B, Wesselborg S, Proikas-Cezanne T, Stork B. Cell Signal. 2010 Jun;22(6):914-25. doi: 10.1016/j.cellsig.2010.01.015. Epub 2010 Jan 28. PMID: 20114074
Molecular suicide notes: last call from apoptosing cells.
Peter C, Wesselborg S, Lauber K. J Mol Cell Biol. 2010 Apr;2(2):78-80. doi: 10.1093/jmcb/mjp045. Epub 2009 Dec 11. PMID: 20008330
Publications 2009
Cell surface externalization of annexin A1 as a failsafe mechanism preventing inflammatory responses during secondary necrosis.
Blume KE, Soeroes S, Waibel M, Keppeler H, Wesselborg S, Herrmann M, Schulze-Osthoff K, Lauber K. J Immunol. 2009 Dec 15;183(12):8138-47. doi: 10.4049/jimmunol.0902250. PMID: 20007579
Hepatitis C virus core protein induces apoptosis-like caspase independent cell death.
Berg CP, Schlosser SF, Neukirchen DK, Papadakis C, Gregor M, Wesselborg S, Stein GM. Virol J. 2009 Dec 1;6:213. doi: 10.1186/1743-422X-6-213. PMID: 19951438
Scent of dying cells: the role of attraction signals in the clearance of apoptotic cells and its immunological consequences.
Muñoz LE, Peter C, Herrmann M, Wesselborg S, Lauber K. Autoimmun Rev. 2010 Apr;9(6):425-30. doi: 10.1016/j.autrev.2009.11.016. Epub 2009 Nov 25. Review. PMID: 19932201
Accelerated clearance of Plasmodium-infected erythrocytes in sickle cell trait and annexin-A7 deficiency.
Lang PA, Kasinathan RS, Brand VB, Duranton C, Lang C, Koka S, Shumilina E, Kempe DS, Tanneur V, Akel A, Lang KS, Foller M, Kun JF, Kremsner PG, Wesselborg S, Laufer S, Clemen CS, Herr C, Noegel AA, Wieder T, Gulbins E, Lang F, Huber SM. Cell Physiol Biochem. 2009;24(5-6):415-28. doi: 10.1159/000257529. Epub 2009 Nov 4. PMID: 19910682
Mycoplasma antigens as a possible trigger for the induction of antimitochondrial antibodies in primary biliary cirrhosis.
Berg CP, Kannan TR, Klein R, Gregor M, Baseman JB, Wesselborg S, Lauber K, Stein GM. Liver Int. 2009 Jul;29(6):797-809. doi: 10.1111/j.1478-3231.2008.01942.x. PMID: 19638108
Effects of bacterial N-acyl homoserine lactones on human Jurkat T lymphocytes-OdDHL induces apoptosis via the mitochondrial pathway.
Jacobi CA, Schiffner F, Henkel M, Waibel M, Stork B, Daubrawa M, Eberl L, Gregor M, Wesselborg S. Int J Med Microbiol. 2009 Nov;299(7):509-19. doi: 10.1016/j.ijmm.2009.03.005. Epub 2009 May 22. PMID: 19464950
The Akt inhibitor triciribine sensitizes prostate carcinoma cells to TRAIL-induced apoptosis.
Dieterle A, Orth R, Daubrawa M, Grotemeier A, Alers S, Ullrich S, Lammers R, Wesselborg S, Stork B. Int J Cancer. 2009 Aug 15;125(4):932-41. doi: 10.1002/ijc.24374. MID: 19422047
Role of BNIP3 in TNF-induced cell death--TNF upregulates BNIP3 expression.
Ghavami S, Eshraghi M, Kadkhoda K, Mutawe MM, Maddika S, Bay GH, Wesselborg S, Halayko AJ, Klonisch T, Los M. Biochim Biophys Acta. 2009 Mar;1793(3):546-60. doi: 10.1016/j.bbamcr.2009.01.002. Epub 2009 Jan 15. PMID: 19321129
Inhibition of Na+/H+ exchanger activity by parvovirus B19 protein NS1.
Lupescu A, Geiger C, Zahir N, Aberle S, Lang PA, Kramer S, Wesselborg S, Kandolf R, Foller M, Lang F, Bock CT. Cell Physiol Biochem. 2009;23(1-3):211-20. doi: 10.1159/000204110. Epub 2009 Feb 18. PMID: 19255516
Unscheduled Akt-triggered activation of cyclin-dependent kinase 2 as a key effector mechanism of apoptin's anticancer toxicity.
Maddika S, Panigrahi S, Wiechec E, Wesselborg S, Fischer U, Schulze-Osthoff K, Los M. Mol Cell Biol. 2009 Mar;29(5):1235-48. doi: 10.1128/MCB.00668-08. Epub 2008 Dec 22. PMID: 19103742
IkappaBzeta expression is regulated by miR-124a.
Lindenblatt C, Schulze-Osthoff K, Totzke G. Cell Cycle. 2009 Jul 1;8(13):2019-23. Epub 2009 Jul 21. PMID: 19502795
Publications 2008
Cancer stem cell markers in common cancers - therapeutic implications.
Klonisch T, Wiechec E, Hombach-Klonisch S, Ande SR, Wesselborg S, Schulze-Osthoff K, Los M. Trends Mol Med. 2008 Oct;14(10):450-60. doi: 10.1016/j.molmed.2008.08.003. Epub 2008 Sep 3. Review. PMID: 18775674
Regulation of calcineurin activity in insulin-secreting cells: stimulation by Hsp90 during glucocorticoid-induced apoptosis.
Ranta F, Düfer M, Stork B, Wesselborg S, Drews G, Häring HU, Lang F, Ullrich S. Cell Signal. 2008 Oct;20(10):1780-6. doi: 10.1016/j.cellsig.2008.06.003. Epub 2008 Jun 18. PMID: 18611438
Akt-mediated phosphorylation of CDK2 regulates its dual role in cell cycle progression and apoptosis.
Maddika S, Ande SR, Wiechec E, Hansen LL, Wesselborg S, Los M. J Cell Sci. 2008 Apr 1;121(Pt 7):979-88. doi: 10.1242/jcs.009530. PMID: 18354084
S100A8/A9 at low concentration promotes tumor cell growth via RAGE ligation and MAP kinase-dependent pathway.
Ghavami S, Rashedi I, Dattilo BM, Eshraghi M, Chazin WJ, Hashemi M, Wesselborg S, Kerkhoff C, Los M. J Leukoc Biol. 2008 Jun;83(6):1484-92. doi: 10.1189/jlb.0607397. Epub 2008 Mar 13. PMID: 18339893
Migration to apoptotic "find-me" signals is mediated via the phagocyte receptor G2A.
Peter C, Waibel M, Radu CG, Yang LV, Witte ON, Schulze-Osthoff K, Wesselborg S, Lauber K. J Biol Chem. 2008 Feb 29;283(9):5296-305. Epub 2007 Dec 18. PMID: 18089568
Apoptosis-associated antigens recognized by autoantibodies in patients with the autoimmune liver disease primary biliary cirrhosis.
Berg CP, Stein GM, Keppeler H, Gregor M, Wesselborg S, Lauber K. Apoptosis. 2008 Jan;13(1):63-75. PMID: 18060504
Interaction with PI3-kinase contributes to the cytotoxic activity of apoptin.
Maddika S, Wiechec E, Ande SR, Poon IK, Fischer U, Wesselborg S, Jans DA, Schulze-Osthoff K, Los M. Oncogene. 2008 May 8;27(21):3060-5. Epub 2007 Dec 3. PMID: 18059340
Myrtucommulone from Myrtus communis induces apoptosis in cancer cells via the mitochondrial pathway involving caspase-9.
Tretiakova I, Blaesius D, Maxia L, Wesselborg S, Schulze-Osthoff K, Cinatl J Jr, Michaelis M, Werz O. Apoptosis. 2008 Jan;13(1):119-31. PMID: 17955373
Publications 2007
Interferon-gamma and tumor necrosis factor-alpha sensitize primarily resistant human endometrial stromal cells to Fas-mediated apoptosis.
Fluhr H, Krenzer S, Stein GM, Stork B, Deperschmidt M, Wallwiener D, Wesselborg S, Zygmunt M, Licht P. J Cell Sci. 2007 Dec 1;120(Pt 23):4126-33. Epub 2007 Nov 14. PMID: 18003704
Catalytically active Yersinia outer protein P induces cleavage of RIP and caspase-8 at the level of the DISC independently of death receptors in dendritic cells.
Gröbner S, Adkins I, Schulz S, Richter K, Borgmann S, Wesselborg S, Ruckdeschel K, Micheau O, Autenrieth IB. Apoptosis. 2007 Oct;12(10):1813-25. PMID: 17624595
Attraction of phagocytes by apoptotic cells is mediated by lysophosphatidylcholine.
Mueller RB, Sheriff A, Gaipl US, Wesselborg S, Lauber K. Autoimmunity. 2007 Jun;40(4):342-4. Review. PMID: 17516225
Platelets recruit human dendritic cells via Mac-1/JAM-C interaction and modulate dendritic cell function in vitro.
Langer HF, Daub K, Braun G, Schönberger T, May AE, Schaller M, Stein GM, Stellos K, Bueltmann A, Siegel-Axel D, Wendel HP, Aebert H, Roecken M, Seizer P, Santoso S, Wesselborg S, Brossart P, Gawaz M. Arterioscler Thromb Vasc Biol. 2007 Jun;27(6):1463-70. Epub 2007 Mar 22. PMID: 17379836
Mitochondria are not required for death receptor-mediated cytosolic acidification during apoptosis.
Waibel M, Kramer S, Lauber K, Lupescu A, Manns J, Schulze-Osthoff K, Lang F, Wesselborg S. Apoptosis. 2007 Mar;12(3):623-30. Epub 2006 Dec 29. PMID: 17195091
Absence of Toll-like receptor 4 signaling results in delayed Yersinia enterocolitica YopP-induced cell death of dendritic cells.
Gröbner S, Schulz S, Soldanova I, Gunst DS, Waibel M, Wesselborg S, Borgmann S, Autenrieth IB. Infect Immun. 2007 Jan;75(1):512-7. Epub 2006 Oct 30. PMID: 17074859
Ca(2+) signaling in antigen receptor-activated B lymphocytes.
Engelke M, Engels N, Dittmann K, Stork B, Wienands J. Immunol Rev. 2007 Aug;218:235-46. Review. PMID: 17624956
Subcellular localization of Grb2 by the adaptor protein Dok-3 restricts the intensity of Ca2+ signaling in B cells.
Stork B, Neumann K, Goldbeck I, Alers S, Kähne T, Naumann M, Engelke M, Wienands J. EMBO J. 2007 Feb 21;26(4):1140-9. Epub 2007 Feb 8. PMID: 17290227
Publications 2006
Yersinia YopP-induced apoptotic cell death in murine dendritic cells is partially independent from action of caspases and exhibits necrosis-like features.
Gröbner S, Autenrieth SE, Soldanova I, Gunst DS, Schaller M, Bohn E, Müller S, Leverkus M, Wesselborg S, Autenrieth IB, Borgmann S. Apoptosis. 2006 Nov;11(11):1959-68. PMID: 17036200
Demonstration of PDC-E1 subunits as major antigens in the complement-fixing fraction M4 and re-evaluation of PDC-E1-specific antibodies in PBC patients.
Berg CP, Stein GM, Klein R, Pascu M, Berg T, Kammer W, Priemer M, Nordheim A, Schulze-Osthoff K, Gregor M, Wesselborg S, Berg PA. Liver Int. 2006 Sep;26(7):846-55. PMID: 16911468
Caspase-3-dependent activation of calcium-independent phospholipase A2 enhances cell migration in non-apoptotic ovarian cancer cells.
Zhao X, Wang D, Zhao Z, Xiao Y, Sengupta S, Xiao Y, Zhang R, Lauber K, Wesselborg S, Feng L, Rose TM, Shen Y, Zhang J, Prestwich G, Xu Y. J Biol Chem. 2006 Sep 29;281(39):29357-68. Epub 2006 Aug 1. PMID: 16882668
Cell-cycle progression and response of germ cell tumors to cisplatin in vitro.
Mueller S, Schittenhelm M, Honecker F, Malenke E, Lauber K, Wesselborg S, Hartmann JT, Bokemeyer C, Mayer F. Int J Oncol. 2006 Aug;29(2):471-9. PMID: 16820891
Caspase-10 in mouse or not?
Jänicke RU, Sohn D, Totzke G, Schulze-Osthoff K.Science. 2006 Jun 30;312(5782):1874. No abstract available. PMID: 16809511
Friend or foe? The proteasome in combined cancer therapy.
Sohn D, Totzke G, Schulze-Osthoff K, Jänicke RU.Cell Cycle. 2006 Apr;5(8):841-5. Epub 2006 Apr 17. Review.PMID: 16628002
A novel member of the IkappaB family, human IkappaB-zeta, inhibits transactivation of p65 and its DNA binding.
Totzke G, Essmann F, Pohlmann S, Lindenblatt C, Jänicke RU, Schulze-Osthoff K.J Biol Chem. 2006 May 5;281(18):12645-54. Epub 2006 Mar 2.PMID: 16513645
The proteasome is required for rapid initiation of death receptor-induced apoptosis.
Sohn D, Totzke G, Essmann F, Schulze-Osthoff K, Levkau B, Jänicke RU.Mol Cell Biol. 2006 Mar;26(5):1967-78.PMID: 16479014
Publications 2005
Cooperative cytotoxicity of proteasome inhibitors and tumor necrosis factor-related apoptosis-inducing ligand in chemoresistant Bcl-2-overexpressing cells.
Nencioni A, Wille L, Dal Bello G, Boy D, Cirmena G, Wesselborg S, Belka C, Brossart P, Patrone F, Ballestrero A. Clin Cancer Res. 2005 Jun 1;11(11):4259-65. PMID: 15930365
STAT3 is essential for Hodgkin lymphoma cell proliferation and is a target of tyrphostin AG17 which confers sensitization for apoptosis.
Holtick U, Vockerodt M, Pinkert D, Schoof N, Stürzenhofecker B, Kussebi N, Lauber K, Wesselborg S, Löffler D, Horn F, Trümper L, Kube D. Leukemia. 2005 Jun;19(6):936-44. PMID: 15912144
Prostaglandin D2 induces programmed cell death in Trypanosoma brucei bloodstream form.
Figarella K, Rawer M, Uzcategui NL, Kubata BK, Lauber K, Madeo F, Wesselborg S, Duszenko M. Cell Death Differ. 2005 Apr;12(4):335-46. PMID: 15678148
Bartonella henselae inhibits apoptosis in Mono Mac 6 cells.
Kempf VA, Schairer A, Neumann D, Grassl GA, Lauber K, Lebiedziejewski M, Schaller M, Kyme P, Wesselborg S, Autenrieth IB. Cell Microbiol. 2005 Jan;7(1):91-104. PMID: 15617526
Evidence for a protective role of Mcl-1 in proteasome inhibitor-induced apoptosis.
Nencioni A, Hua F, Dillon CP, Yokoo R, Scheiermann C, Cardone MH, Barbieri E, Rocco I, Garuti A, Wesselborg S, Belka C, Brossart P, Patrone F, Ballestrero A. Blood. 2005 Apr 15;105(8):3255-62. Epub 2004 Dec 21. PMID: 15613543
Type I and type II reactions in TRAIL-induced apoptosis -- results from dose-response studies.
Rudner J, Jendrossek V, Lauber K, Daniel PT, Wesselborg S, Belka C.Oncogene. 2005 Jan 6;24(1):130-40.PMID: 15531922
Ets1 is an effector of protein kinase Calpha in cancer cells.
Vetter M, Blumenthal SG, Lindemann RK, Manns J, Wesselborg S, Thomssen C, Dittmer J. Oncogene. 2005 Jan 20;24(4):650-61. Erratum in: Oncogene. 2005 Jun 16;24(26):4319. PMID: 15531915
Identification of p54(nrb) and the 14-3-3 Protein HS1 as TNF-alpha-inducible genes related to cell cycle control and apoptosis in human arterial endothelial cells.
Stier S, Totzke G, Gruewald E, Neuhaus T, Fronhoffs S, Schoneborn S, Vetter H, Ko Y. J Biochem Mol Biol. 2005 Jul 31;38(4):447-56. PMID: 16053712
Caspase-10 sensitizes breast carcinoma cells to TRAIL-induced but not tumor necrosis factor-induced apoptosis in a caspase-3-dependent manner.
Engels IH, Totzke G, Fischer U, Schulze-Osthoff K, Jänicke RU. Mol Cell Biol. 2005 Apr;25(7):2808-18. PMID: 15767684
Publications 2004
Clearance of apoptotic cells: getting rid of the corpses.
Lauber K, Blumenthal SG, Waibel M, Wesselborg S. Mol Cell. 2004 May 7;14(3):277-87. Review. PMID: 15125832
Tumor necrosis factor-related apoptosis-inducing ligand cooperates with anticancer drugs to overcome chemoresistance in antiapoptotic Bcl-2 family members expressing jurkat cells.
Ballestrero A, Nencioni A, Boy D, Rocco I, Garuti A, Mela GS, Van Parijs L, Brossart P, Wesselborg S, Patrone F. Clin Cancer Res. 2004 Feb 15;10(4):1463-70. PMID: 14977850
Apoptosis resistance of MCF-7 breast carcinoma cells to ionizing radiation is independent of p53 and cell cycle control but caused by the lack of caspase-3 and a caffeine-inhibitable event.
Essmann F, Engels IH, Totzke G, Schulze-Osthoff K, Jänicke RU. Cancer Res. 2004 Oct 1;64(19):7065-72. PMID: 15466201
Publications 2003
Cyclopentenone prostaglandins induce lymphocyte apoptosis by activating the mitochondrial apoptosis pathway independent of external death receptor signaling.
Nencioni A, Lauber K, Grünebach F, Van Parijs L, Denzlinger C, Wesselborg S, Brossart P. J Immunol. 2003 Nov 15;171(10):5148-56. PMID: 14607914
Role of peroxisome proliferator-activated receptor gamma and its ligands in the control of immune responses.
Nencioni A, Wesselborg S, Brossart P. Crit Rev Immunol. 2003;23(1-2):1-13. Review. PMID: 12906257
Apoptotic cells induce migration of phagocytes via caspase-3-mediated release of a lipid attraction signal.
Lauber K, Bohn E, Kröber SM, Xiao YJ, Blumenthal SG, Lindemann RK, Marini P, Wiedig C, Zobywalski A, Baksh S, Xu Y, Autenrieth IB, Schulze-Osthoff K, Belka C, Stuhler G, Wesselborg S. Cell. 2003 Jun 13;113(6):717-30. PMID:12809603
Ribavirin and alpha interferon enhance death receptor-mediated apoptosis and caspase activation in human hepatoma cells.
Schlosser SF, Schuler M, Berg CP, Lauber K, Schulze-Osthoff K, Schmahl FW, Wesselborg S. Antimicrob Agents Chemother. 2003 Jun;47(6):1912-21. PMID: 12760867
Tributyltin (TBT) induces ultra-rapid caspase activation independent of apoptosome formation in human platelets.
Berg CP, Rothbart A, Lauber K, Stein GM, Engels IH, Belka C, Jänicke RU, Schulze-Osthoff K, Wesselborg S. Oncogene. 2003 Feb 6;22(5):775-80. PMID: 12569371
The tyrosine kinase Lck is involved in regulation of mitochondrial apoptosis pathways.
Belka C, Gruber C, Jendrossek V, Wesselborg S, Budach W. Oncogene. 2003 Jan 16;22(2):176-85. PMID: 12527887
The use of suppression subtractive hybridization for the study of SDF-1alpha induced gene-expression in human endothelial cells.
Neuhaus T, Lutz C, Stier S, Totzke G, Gruenewald E, Fronhoffs S, Sachinidis A, Vetter H, Ko YD. Mol Cell Probes. 2003 Oct;17(5):245-52. PMID: 14580399
Cyclooxygenase-2 (COX-2) inhibitors sensitize tumor cells specifically to death receptor-induced apoptosis independently of COX-2 inhibition.
Totzke G, Schulze-Osthoff K, Jänicke RU. Oncogene. 2003 Sep 11;22(39):8021-30. PMID: 12970750
Staphylococcus aureus alpha-toxin-induced cell death: predominant necrosis despite apoptotic caspase activation.
Essmann F, Bantel H, Totzke G, Engels IH, Sinha B, Schulze-Osthoff K, Jänicke RU. Cell Death Differ. 2003 Nov;10(11):1260-72. PMID: 12894214
Stromal cell-derived factor 1alpha (SDF-1alpha) induces gene-expression of early growth response-1 (Egr-1) and VEGF in human arterial endothelial cells and enhances VEGF induced cell proliferation.
Neuhaus T, Stier S, Totzke G, Gruenewald E, Fronhoffs S, Sachinidis A, Vetter H, Ko YD. Cell Prolif. 2003 Apr;36(2):75-86. PMID: 12680875
Publications 2002
Legionella pneumophila induces apoptosis via the mitochondrial death pathway.
Neumeister B, Faigle M, Lauber K, Northoff H, Wesselborg S. Microbiology. 2002 Nov;148(Pt 11):3639-50. PMID: 12427954
Cyclopentenone prostaglandins induce caspase activation and apoptosis in dendritic cells by a PPAR-gamma-independent mechanism: regulation by inflammatory and T cell-derived stimuli.
Nencioni A, Lauber K, Grünebach F, Brugger W, Denzlinger C, Wesselborg S, Brossart P. Exp Hematol. 2002 Sep;30(9):1020-8. PMID: 12225793
A caspase-related protease regulates apoptosis in yeast.
Madeo F, Herker E, Maldener C, Wissing S, Lächelt S, Herlan M, Fehr M, Lauber K, Sigrist SJ, Wesselborg S, Fröhlich KU. Mol Cell. 2002 Apr;9(4):911-7. PMID: 11983181
A method for the rapid construction of cRNA standard curves in quantitative real-time reverse transcription polymerase chain reaction.
Fronhoffs S, Totzke G, Stier S, Wernert N, Rothe M, Brüning T, Koch B, Sachinidis A, Vetter H, Ko Y. Mol Cell Probes. 2002 Apr;16(2):99-110. PMID: 12030760
Publications 2001
Human mature red blood cells express caspase-3 and caspase-8, but are devoid of mitochondrial regulators of apoptosis.
Berg CP, Engels IH, Rothbart A, Lauber K, Renz A, Schlosser SF, Schulze-Osthoff K, Wesselborg S. Cell Death Differ. 2001 Dec;8(12):1197-206. PMID: 11753567
Wild-type, mitochondrial and ER-restricted Bcl-2 inhibit DNA damage-induced apoptosis but do not affect death receptor-induced apoptosis.
Rudner J, Lepple-Wienhues A, Budach W, Berschauer J, Friedrich B, Wesselborg S, Schulze-Osthoff K, Belka C. J Cell Sci. 2001 Dec;114(Pt 23):4161-72. PMID: 11739649
The adapter protein apoptotic protease-activating factor-1 (Apaf-1) is proteolytically processed during apoptosis.
Lauber K, Appel HA, Schlosser SF, Gregor M, Schulze-Osthoff K, Wesselborg S.J Biol Chem. 2001 Aug 10;276(32):29772-81. Epub 2001 May 31. PMID: 11387322
Staurosporine and conventional anticancer drugs induce overlapping, yet distinct pathways of apoptosis and caspase activation.
Stepczynska A, Lauber K, Engels IH, Janssen O, Kabelitz D, Wesselborg S, Schulze-Osthoff K. Oncogene. 2001 Mar 8;20(10):1193-202. PMID: 11313863
Effects of nebivolol on proliferation and apoptosis of human coronary artery smooth muscle and endothelial cells.
Brehm BR, Wolf SC, Bertsch D, Klaussner M, Wesselborg S, Schüler S, Schulze-Osthoff K. Cardiovasc Res. 2001 Feb 1;49(2):430-9. PMID: 11164853
Prevention of human smooth muscle cell proliferation without induction of apoptosis by the topoisomerase I inhibitor topotecan.
Brehm BR, Bock C, Wesselborg S, Pfeiffer S, Schüler S, Schulze-Osthoff K. Biochem Pharmacol. 2001 Jan 1;61(1):119-27. PMID: 11137716
Publications 2000
The serine phosphatases PP1 and PP2A associate with and activate the actin-binding protein cofilin in human T lymphocytes.
Ambach A, Saunus J, Konstandin M, Wesselborg S, Meuer SC, Samstag Y. Eur J Immunol. 2000 Dec;30(12):3422-31. PMID: 11093160
Caspase-8/FLICE functions as an executioner caspase in anticancer drug-induced apoptosis.
Engels IH, Stepczynska A, Stroh C, Lauber K, Berg C, Schwenzer R, Wajant H, Jänicke RU, Porter AG, Belka C, Gregor M, Schulze-Osthoff K, Wesselborg S. Oncogene. 2000 Sep 21;19(40):4563-73. PMID: 11030145
Differential role of caspase-8 and BID activation during radiation- and CD95-induced apoptosis.
Belka C, Rudner J, Wesselborg S, Stepczynska A, Marini P, Lepple-Wienhues A, Faltin H, Bamberg M, Budach W, Schulze-Osthoff K. Oncogene. 2000 Feb 24;19(9):1181-90. PMID: 10713706
Publications 1999
The role of caspases in development, immunity, and apoptotic signal transduction: lessons from knockout mice.
Los M, Wesselborg S, Schulze-Osthoff K. Immunity. 1999 Jun;10(6):629-39. Review. No abstract available. PMID: 10403638
Mistletoe lectin activates caspase-8/FLICE independently of death receptor signaling and enhances anticancer drug-induced apoptosis.
Bantel H, Engels IH, Voelter W, Schulze-Osthoff K, Wesselborg S. Cancer Res. 1999 May 1;59(9):2083-90. PMID: 10232592
P2Z purinoreceptor ligation induces activation of caspases with distinct roles in apoptotic and necrotic alterations of cell death.
Ferrari D, Los M, Bauer MK, Vandenabeele P, Wesselborg S, Schulze-Osthoff K. FEBS Lett. 1999 Mar 19;447(1):71-5. PMID: 10218585
Anticancer drugs induce caspase-8/FLICE activation and apoptosis in the absence of CD95 receptor/ligand interaction.
Wesselborg S, Engels IH, Rossmann E, Los M, Schulze-Osthoff K. Blood. 1999 May 1;93(9):3053-63. PMID: 10216102
Publications 1998
Differential regulation and ATP requirement for caspase-8 and caspase-3 activation during CD95- and anticancer drug-induced apoptosis.
Ferrari D, Stepczynska A, Los M, Wesselborg S, Schulze-Osthoff K. J Exp Med. 1998 Sep 7;188(5):979-84. PMID: 9730899
Apoptosis signaling by death receptors.
Schulze-Osthoff K, Ferrari D, Los M, Wesselborg S, Peter ME. Eur J Biochem. 1998 Jun 15;254(3):439-59. Review. PMID: 9688254
Role of reactive oxygen intermediates in activation-induced CD95 (APO-1/Fas) ligand expression.
Bauer MK, Vogt M, Los M, Siegel J, Wesselborg S, Schulze-Osthoff K. J Biol Chem. 1998 Apr 3;273(14):8048-55. PMID: 9525905
Publications 1997
Extracellular ATP activates transcription factor NF-kappaB through the P2Z purinoreceptor by selectively targeting NF-kappaB p65.
Ferrari D, Wesselborg S, Bauer MK, Schulze-Osthoff K. J Cell Biol. 1997 Dec 29;139(7):1635-43. PMID: 9412459
Regulation of NF-kappa B activation by MAP kinase cascades.
Schulze-Osthoff K, Ferrari D, Riehemann K, Wesselborg S. Immunobiology. 1997 Dec;198(1-3):35-49. Review. PMID: 9442376
Activation of transcription factor NF-kappaB and p38 mitogen-activated protein kinase is mediated by distinct and separate stress effector pathways.
Wesselborg S, Bauer MK, Vogt M, Schmitz ML, Schulze-Osthoff K. J Biol Chem. 1997 May 9;272(19):12422-9. PMID: 9139689
The Caenorhabditis elegans death protein Ced-4 contains a motif with similarity to the mammalian 'death effector domain'.
Bauer MK, Wesselborg S, Schulze-Osthoff K. FEBS Lett. 1997 Feb 3;402(2-3):256-8. PMID: 9037206
Oxidative stress and signal transduction.
Schulze-Osthoff K, Bauer MK, Vogt M, Wesselborg S. Int J Vitam Nutr Res. 1997;67(5):336-42. Review. PMID: 9350475
Publications 1996
Competitive inhibition of calcineurin phosphatase activity by its autoinhibitory domain.
Sagoo JK, Fruman DA, Wesselborg S, Walsh CT, Bierer BE. Biochem J. 1996 Dec 15;320 ( Pt 3):879-84. PMID: 9003375
[Oxygen radicals as second messengers of gene expression].
Schulze-Osthoff K, Wesselborg S. Dtsch Med Wochenschr. 1996 Oct 18;121(42):1301-2. German. No abstract available. PMID: 8964205
Identification of a physical interaction between calcineurin and nuclear factor of activated T cells (NFATp).
Wesselborg S, Fruman DA, Sagoo JK, Bierer BE, Burakoff SJ. J Biol Chem. 1996 Jan 19;271(3):1274-7. PMID: 8576111
Publications 1994
Costimulatory signals for human T-cell activation induce nuclear translocation of pp19/cofilin.
Samstag Y, Eckerskorn C, Wesselborg S, Henning S, Wallich R, Meuer SC. Proc Natl Acad Sci U S A. 1994 May 10;91(10):4494-8. PMID: 8183936
Publications 1993
Triggering via the alternative CD2 pathway induces apoptosis in activated human T lymphocytes.
Wesselborg S, Prüfer U, Wild M, Schraven B, Meuer SC, Kabelitz D. Eur J Immunol. 1993 Oct;23(10):2707-10. PMID: 7691614
Induction of activation-driven death (apoptosis) in activated but not resting peripheral blood T cells.
Wesselborg S, Janssen O, Kabelitz D. J Immunol. 1993 May 15;150(10):4338-45. PMID: 8482839
Activation-driven death of human T cell clones: time course kinetics of the induction of cell shrinkage, DNA fragmentation, and cell death.
Wesselborg S, Kabelitz D. Cell Immunol. 1993 Apr 15;148(1):234-41. PMID: 8098667
Publications 1992
Life and death of a superantigen-reactive human CD4+ T cell clone: staphylococcal enterotoxins induce death by apoptosis but simultaneously trigger a proliferative response in the presence of HLA-DR+ antigen-presenting cells.
Kabelitz D, Wesselborg S. Int Immunol. 1992 Dec;4(12):1381-8. PMID: 1363055
Immunosuppression by OKT3--induction of programmed cell death (apoptosis) as a possible mechanism of action.
Janssen O, Wesselborg S, Kabelitz D. Transplantation. 1992 Jan;53(1):233-4. No abstract available. PMID: 1531094
Publications 1991
The primary response of human gamma/delta + T cells to Mycobacterium tuberculosis is restricted to V gamma 9-bearing cells.
Kabelitz D, Bender A, Prospero T, Wesselborg S, Janssen O, Pechhold K. J Exp Med. 1991 Jun 1;173(6):1331-8. PMID: 1827825
Activation and activation-driven death of human gamma/delta T cells.
Kabelitz D, Pechhold K, Bender A, Wesselborg S, Wesch D, Friese K, Janssen O. Immunol Rev. 1991 Apr;120:71-88. Review. PMID: 1677929
Selective activation of gamma/delta + T cell clones by single anti-CD2 antibodies.
Wesselborg S, Janssen O, Pechhold K, Kabelitz D. J Exp Med. 1991 Feb 1;173(2):297-304. PMID: 1703204
Activation and deactivation of cloned gamma/delta T cells.
Kabelitz D, Wesselborg S, Pechold K, Janssen O. Curr Top Microbiol Immunol. 1991;173:197-202. No abstract available. PMID: 1833143
T cell receptor/CD3-signaling induces death by apoptosis in human T cell receptor gamma delta + T cells.
Janssen O, Wesselborg S, Heckl-Ostreicher B, Pechhold K, Bender A, Schondelmaier S, Moldenhauer G, Kabelitz D. J Immunol. 1991 Jan 1;146(1):35-9. PMID: 1824593