Publications

Publications 2025

Towards routine high-throughput analysis of fecal bile acids: validation of an enzymatic cycling method for the quantification of total bile acids in human stool samples on fully automated clinical chemistry analyzers.
Masetto A, Leber T, Fromel T, Peter C, Prager K and Grimmler M. Clin Chem Lab Med. 2025 Jan 23. doi: 10.1515/cclm-2024-1414. Online ahead of print.

The ER protein CANX (calnexin)-mediated autophagy protects against alzheimer disease.
Shen H, Xie Y, Wang Y, Xie Y, Wang Y, Su Z, Zhao L, Yao S, Cao X, Liang J, Long J, Zhong R, Tang J, Wang S, Zhang L, Wang X, Stork B, Cui L, Wu W. Autophagy. 2025 Jan 15:1-20. doi: 10.1080/15548627.2024.2447206. Online ahead of print.PMID: 39813987

Antineoplastic therapy affects the in vitro phenotype and functionality of healthy human bone marrow-derived mesenchymal stromal cells
Scherer B, Bogun L, Koch A, Jäger P, Maus U, Schmitt L, Krings KS, Wesselborg S, Haas R, Schroeder T, Geyh S. Arch Toxicol. 2025 Jan;99(1):393-406. doi: 10.1007/s00204-024-03898-w. Epub 2024 Nov 12.PMID: 39531065

Publications 2024

Novel 4-alkoxy Meriolin Congeners Potently Induce Apoptosis in Leukemia and Lymphoma Cells.
Krings KS, Wassenberg TR, Cea-Medina P, Schmitt L, Lechtenberg I, Llewellyn TR, Qin N, Gohlke H, Wesselborg S, Müller TJJ. Molecules. 2024 Dec 23;29(24):6050. doi: 10.3390/molecules29246050. PMID: 39770138

Performance evaluation of enzymatic total bile acid (TBA) routine assays: systematic comparison of five fifth-generation TBA cycling methods and their individual bile acid recovery from HPLC-MS/MS reference.
Grimmler M, Frömel T, Masetto A, Müller H, Leber T, Peter C. Clin Chem Lab Med. 2024 Nov 29. doi: 10.1515/cclm-2024-1029. Online ahead of print.PMID: 39607980

Targeting mitochondrial metabolism by the mitotoxin bromoxib in leukemia and lymphoma cells
Schmitt L, Krings KS, Wolsing A, Buque X, Zimmermann M, Flores-Romero H, Lenz T, Lechtenberg I, Peter C, Stork B, Teusch N, Proksch P, Stühler K, García-Sáez A, Reichert A, Aspichueta P, Bhatia S and Wesselborg S. Cell Commun Signal 2024 Nov 12;22(1):541. doi: 10.1186/s12964-024-01913-2.

Performance evaluation of enzymatic total bile acid (TBA) routine assays: systematic comparison of five fifth-generation TBA cycling methods and their individual bile acid recovery from HPLC-MS/MS reference
Grimmler M, Frömel T, Masetto A, Müller H, Leber T, Peter C. Clin Chem Lab Med. 2024 Nov 29. doi: 10.1515/cclm-2024-1029. Online ahead of print. PMID: 39607980

Mfn2 induces NCLX-mediated calcium release from mitochondria.
Kolitsida P, Saha A, Caliri A, Assali E, Riera AM, Itskanov S, Magana CS, Stork B, Shirihai O, Sekler I, Koehler CM, van der Bliek AM. bioRxiv [Preprint]. 2024 Aug 13:2024.08.05.606704. doi: 10.1101/2024.08.05.606704.PMID: 39149365

Application of Cyclic Diaryliodonium Salts in the Synthesis of Axially Chiral Natural Product Analogues.
Klischan MKT, David C, Grudzinski D, Frey W, Stork B, Pietruszka J. Org Lett. 2024 Jun 28;26(25):5258-5262. doi: 10.1021/acs.orglett.4c01308. Epub 2024 Jun 17.PMID: 38885455

Novel meriolin derivatives potently inhibit cell cycle progression and transcription in leukemia and lymphoma cells via inhibition of cyclin-dependent kinases (CDKs)
Schmitt L, Hoppe J, Cea-Medina P, Bruch P-M, Krings KS, Lechtenberg I, Drießen D, Peter Ch, Bhatia S, Dietrich S, Stork B, Fritz G, Gohlke H, Müller ThJJ, Wesselborg S. Cell Death Discov. 2024 Jun 11; 10(1):279. PMID: 38862521, doi: 10.1038/s41420-024-02056-6

Combined inhibition of class 1-PI3K-alpha and delta isoforms causes senolysis by inducing p21WAF1/CIP1 proteasomal degradation in senescent cells.
Neuwahl J, Neumann CA, Fitz AC, Biermann AD, Magel M, Friedrich A, Sellin L, Stork B, Piekorz RP, Proksch P, Budach W, Jänicke RU, Sohn D. Cell Death Dis. 2024 May 29;15(5):373. doi: 10.1038/s41419-024-06755-x.PMID: 38811535

From the Total Synthesis of Semi-Viriditoxin, Semi-Viriditoxic Acid and Dimeric Naphthopyranones to their Biological Activities in Burkitt B Cell Lymphoma.
Weber F, Weber A, Schmitt L, Lechtenberg I, Greb J, Henßen B, Wesselborg S, Pietruszka J. Chemistry. 2024 May 2;30(25):e202400559. doi: 10.1002/chem.202400559. Epub 2024 Mar 15.PMID: 38411573

Novel meriolin derivatives activate the mitochondrial apoptosis pathway in the presence of antiapoptotic Bcl-2
Schmitt L, Lechtenberg I, Drießen D, Flores-Romero H, Skowron M, Sekeres M, Hoppe J, Krings K, Llewellyn T, Peter C, Stork B, Qin N, Bhatia S, Nettersheim D, Fritz G, García-Sáez A, Müller T and Wesselborg S. Cell Death Discov. 2024 Mar 9;10(1):125.  doi: 10.1038/s41420-024-01901-y

Publications 2023

Modular Approach for the Synthesis and Bioactivity Profiling of 8,8'-Biflavones.
Klischan MKT, Mazzone F, Berning L, Greb J, Schlamkow M, Haase M, Frey W, Stork B, Pfeffer K, Pietruszka J. ACS Omega. 2023 Oct 27;8(44):41816-41834. doi: 10.1021/acsomega.3c06503. eCollection 2023 Nov 7.PMID: 37970025

Vaccine-induced SARS-CoV-2 antibody response: the comparability of S1-specific binding assays depends on epitope and isotype discrimination.
Schest S, Langer C, Stiegler Y, Karnuth B, Arends J, Stiegler H, Masetto T, Peter C, Grimmler M. Front Immunol. 2023 Oct 26;14:1257265. doi: 10.3389/fimmu.2023.1257265. eCollection 2023. PMID: 37965324

The Impact of p70S6 Kinase-Dependent Phosphorylation of Gemin2 in UsnRNP Biogenesis.
Esser LM, Li Q, Jüdt M, Kähne T, Stork B, Grimmler M, Wesselborg S, Peter C. Int J Mol Sci. 2023 Oct 25;24(21):15552. doi: 10.3390/ijms242115552. PMID: 37958537

The Golgi stacking protein GRASP55 is targeted by the natural compound prodigiosin.
Berning L, Lenz T, Bergmann AK, Poschmann G, Brass HUC, Schlütermann D, Friedrich A, Mendiburo MJ, David C, Akgün S, Pietruszka J, Stühler K, Stork B. Cell Commun Signal. 2023 Oct 5;21(1):275. doi: 10.1186/s12964-023-01275-1.PMID: 37798768

Comprehensive Comparison of the Capacity of Functionalized Sepharose, Magnetic Core, and Polystyrene Nanoparticles to Immuno-Precipitate Procalcitonin from Human Material for the Subsequent Quantification by LC-MS/MS. 
Masetto T, Matzenbach K, Reuschel T, Tölke SA, Schneider K, Esser LM, Reinhart M, Bindila L, Peter C, Grimmler M. Int J Mol Sci. 2023 Jun 30;24(13):10963. doi: 10.3390/ijms241310963. PMID: 37446139

Metamorphic proteins at the basis of human autophagy initiation and lipid transfer.
Nguyen A, Lugarini F, David C, Hosnani P, Alagöz Ç, Friedrich A, Schlütermann D, Knotkova B, Patel A, Parfentev I, Urlaub H, Meinecke M, Stork B, Faesen AC. Mol Cell. 2023 Jun 15;83(12):2077-2090.e12. doi: 10.1016/j.molcel.2023.04.026. Epub 2023 May 19.PMID: 37209685

Characterization of Native COMPASS Complex in Urothelial Carcinoma Cells by Size Exclusion Chromatography.
Peter C, Schulz WA, Whongsiri P. Methods Mol Biol. 2023;2684:101-109. doi: 10.1007/978-1-0716-3291-8_5. PMID: 37410229

Phosphorylation of pICln by the autophagy activating kinase ULK1 regulates snRNP biogenesis and splice activity of the cell.
Esser LM, Schmitz K, Hillebrand F, Erkelenz S, Schaal H, Stork B, Grimmler M, Wesselborg S, Peter C. Comput Struct Biotechnol J. 2023 Mar 16;21:2100-2109. doi: 10.1016/j.csbj.2023.03.015. eCollection 2023. PMID: 36968021 Free PMC article.

Bioinformatical Design and Performance Evaluation of a Nucleocapsid- and an RBD-Based Particle Enhanced Turbidimetric Immunoassay (PETIA) to Quantify the Wild Type and Variants of Concern-Derived Immunoreactivity of SARS-CoV-2.
Wey L, Masetto T, Spaeth A, Brehm J, Kochem C, Reinhart M, Müller H, Kempin U, Lorenz F, Peter C, Grimmler M. Biomedicines. 2023 Jan 8;11(1):160. doi: 10.3390/biomedicines11010160.PMID: 36672668

Publications 2022

Cardiac injection of USSC boosts remuscularization of the infarcted heart by shaping the T-cell response.
Ding Z, Tan K, Alter C, Temme S, Bouvain P, Owenier C, Hänsch S, Wesselborg S, Peter C, Weidtkamp-Peters S, Flögel U, Schira-Heinen J, Stühler K, Hesse J, Kögler G, Schrader J. J Mol Cell Cardiol. 2022 Dec 6:S0022-2828(22)00566-1. doi: 10.1016/j.yjmcc.2022.11.006. 

The mycotoxin viriditoxin induces leukemia- and lymphoma-specific apoptosis by targeting mitochondrial metabolism.
Stuhldreier F, Schmitt L, Lenz T, Hinxlage I, Zimmermann M, Wollnitzke P, Schliehe-Diecks J, Liu Y, Jäger P, Geyh S, Teusch N, Peter C, Bhatia S, Haas R, Levkau B, Reichert A, Stühler K, Proksch P, Stork B, Wesselborg S. Cell Death Dis 2022 Nov 8; volume 13, Article number: 938 (2022); PMID: 36347842  PMCID: PMC9643474  DOI: 10.1038/s41419-022-05356-w

Development of Macrocyclic PRMT5-Adaptor Protein Interaction Inhibitors.
Krzyzanowski A, Esser LM, Willaume A, Prudent R, Peter C, 't Hart P, Waldmann H. J Med Chem. 2022 Nov 15. doi: 10.1021/acs.jmedchem.2c01273. Online ahead of print.PMID: 36378254

SARS-CoV-2 antibody progression and neutralizing potential in mild symptomatic COVID-19 patients - a comparative long term post-infection study.
Brehm J, Spaeth A, Dreßler L, Masetto T, Dannenberg R, Peter C, Grimmler M. Front Immunol. 2022 Aug 17;13:915338. doi: 10.3389/fimmu.2022.915338. eCollection 2022

NF90/NFAR (nuclear factors associated with dsRNA) - a new methylation substrate of the PRMT5-WD45-RioK1 complex.
Cox J, Esser L M, Judt M, Schmitz K, Reiffert K, Grimmler M, Stork B, Wesselborg S & Peter C. Biol Chem. 2022, doi.org/10.1515/hsz-2022-0136

National External Quality Assessment and direct method comparison reflect crucial deviations of Procalcitonin measurements in Germany.
Masetto T, Eidizadeh A, Peter C, Grimmler M. Clin Chim Acta. 2022 Feb 12:S0009-8981(22)00057-2. doi: 10.1016/j.cca.2022.02.007. Online ahead of print. PMID: 35167843

Publications 2021

Characterization of the Diagnostic Performance of a Novel COVID-19 PETIA in Comparison to Four Routine N-, S- and RBD-Antigen Based Immunoassays.
Spaeth A, Masetto Th, Brehm J, Wey L, Kochem Ch, Brehm M, Peter C and Grimmler M. Diagnostics. 2021, 11(8). https://doi.org/10.3390/diagnostics11081332

TNF-induced necroptosis initiates early autophagy events via RIPK3-dependent AMPK activation, but inhibits late autophagy.
Wu W, Wang X, Sun Y, Berleth N, Deitersen J, Schlütermann D, Stuhldreier F, Wallot-Hieke N, José Mendiburo M, Cox J, Peter C, Bergmann AK, Stork B. Autophagy. 2021 Dec;17(12):3992-4009. doi: 10.1080/15548627.2021.1899667. Epub 2021 Mar 28. PMID: 33779513

Fin56-induced ferroptosis is supported by autophagy-mediated GPX4 degradation and functions synergistically with mTOR inhibition to kill bladder cancer cells.
Sun Y, Berleth N, Wu W, Schlütermann D, Deitersen J, Stuhldreier F, Berning L, Friedrich A, Akgün S, Mendiburo MJ, Wesselborg S, Conrad M, Berndt C, Stork B. Cell Death Dis. 2021 Oct 29;12(11):1028. doi: 10.1038/s41419-021-04306-2. PMID: 34716292

ULK1 phosphorylation of striatin activates protein phosphatase 2A and autophagy.
Hu Z, Sankar DS, Vu B, Leytens A, Vionnet C, Wu W, Stumpe M, Martínez-Martínez E, Stork B, Dengjel J. Cell Rep. 2021 Sep 28;36(13):109762. doi: 10.1016/j.celrep.2021.109762. PMID: 3459214

FIP200 controls the TBK1 activation threshold at SQSTM1/p62-positive condensates.
Schlütermann D, Berleth N, Deitersen J, Wallot-Hieke N, Friesen O, Wu W, Stuhldreier F, Sun Y, Berning L, Friedrich A, Mendiburo MJ, Peter C, Wiek C, Hanenberg H, Stefanski A, Stühler K, Stork B.Sci Rep. 2021 Jul 5;11(1):13863. doi: 10.1038/s41598-021-92408-4.PMID: 34226595

An essential role of the autophagy activating kinase ULK1 in snRNP biogenesis.
Schmitz K, Cox J, Esser LM, Voss M, Sander K, Löffler A, Hillebrand F, Erkelenz S, Schaal H, Kähne T, Klinker S, Zhang T, Nagel-Steger L, Willbold D, Seggewiß S, Schlütermann D, Stork B, Grimmler M, Wesselborg S, Peter C. Nucleic Acids Res. 2021 Jun 21;49(11):6437-6455. doi: 10.1093/nar/gkab452

Phosphorylation of GAPVD1 Is Regulated by the PER Complex and Linked to GAPVD1 Degradation.
Ibrahim H, Reus P, Mundorf AK, Grothoff AL, Rudenko V, Buschhaus C, Stefanski A, Berleth N, Stork B, Stühler K, Kalfalah F, Reinke H. Int J Mol Sci. 2021 Apr 6;22(7):3787. doi: 10.3390/ijms22073787. PMID: 33917494

40 Years of Research on Polybrominated Diphenyl Ethers (PBDEs)-A Historical Overview and Newest Data of a Promising Anticancer Drug.
Schmitt L, Hinxlage I, Cea P, Gohlke H, Wesselborg S. Molecules. 2021 Feb 13;26(4):995. doi: 10.3390/molecules26040995

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.
Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, et. al. Autophagy. 2021 Jan;17(1):1-382. doi: 10.1080/15548627.2020.1797280. Epub 2021 Feb 8. PMID: 33634751

Dithiodiketopiperazine derivatives from endophytic fungi Trichoderma harzianum and Epicoccum nigrum.
Harwoko H, Daletos G, Stuhldreier F, Lee J, Wesselborg S, Feldbrügge M, Müller WEG, Kalscheuer R, Ancheeva E, Proksch P. Nat Prod Res. 2021 Jan;35(2):257-265. doi: 10.1080/14786419.2019.1627348. Epub 2019 Jun 18

Publications 2020

Induction of New Lactam Derivatives From the Endophytic Fungus Aplosporella javeedii Through an OSMAC Approach.
Gao Y, Stuhldreier F, Schmitt L, Wesselborg S, Guo Z, Zou K, Mándi A, Kurtán T, Liu Z, Proksch P. Front Microbiol. 2020 Nov 4;11:600983. doi: 10.3389/fmicb.2020.600983. eCollection 2020. PMID: 33250887

The phospho-barcode of RIPK1: complementarity or redundancy?
Wu W, Stork B. Mol Cell Oncol. 2020 Jul 16;7(5):1776085. doi: 10.1080/23723556.2020.1776085. eCollection 2020. PMID: 32944633

Sesterterpenes and macrolide derivatives from the endophytic fungus Aplosporella javeedii.
Gao Y, Stuhldreier F, Schmitt L, Wesselborg S, Wang L, Müller WEG, Kalscheuer R, Guo Z, Zou K, Liu Z, Proksch P.Fitoterapia. 2020 Oct;146:104652. doi: 10.1016/j.fitote.2020.104652. Epub 2020 Jun 6.PMID: 32512149

Carbamoyl-Phosphate Synthase 1 as a Novel Target of Phomoxanthone A, a Bioactive Fungal Metabolite.
Ceccacci S, Deitersen J, Mozzicafreddo M, Morretta E, Proksch P, Wesselborg S, Stork B, Monti MC.Biomolecules. 2020 Jun 2;10(6):846. doi: 10.3390/biom10060846.PMID: 32498414

The Autophagy-Initiating Kinase ULK1 Controls RIPK1-Mediated Cell Death.
Wu W, Wang X, Berleth N, Deitersen J, Wallot-Hieke N, Böhler P, Schlütermann D, Stuhldreier F, Cox J, Schmitz K, Seggewiß S, Peter C, Kasof G, Stefanski A, Stühler K, Tschapek A, Gödecke A, Stork B. Cell Rep. 2020 Apr 21;31(3):107547. doi: 10.1016/j.celrep.2020.107547. PMID: 32320653

Publications 2019

First Results from a Screening of 300 Naturally Occurring Compounds: 4,6-dibromo-2-(2',4'-dibromophenoxy)phenol, 4,5,6-tribromo-2-(2',4'-dibromophenoxy)phenol, and 5-epi-nakijinone Q as Substances with the Potential for Anticancer Therapy.
Mayer S, Prechtl M, Liebfried P, Cadeddu RP, Stuhldreier F, Kohl M, Wenzel F, Stork B, Wesselborg S, Proksch P, Germing U, Haas R, Jäger P. Mar Drugs. 2019 Sep 5;17(9):521. doi: 10.3390/md17090521. PMID: 31491907

Anthraquinones and autophagy - Three rings to rule them all?
Deitersen J, El-Kashef DH, Proksch P, Stork B. Bioorg Med Chem. 2019 Oct 15;27(20):115042. doi: 10.1016/j.bmc.2019.115042. Epub 2019 Aug 8. PMID: 31420258

Azaphilone pigments and macrodiolides from the coprophilous fungus Coniella fragariae.
Yu H, Sperlich J, Höfert SP, Janiak C, Teusch N, Stuhldreier F, Wesselborg S, Wang C, Kassack MU, Dai H, Liu Z, Proksch P. Fitoterapia. 2019 Sep;137:104249. doi: 10.1016/j.fitote.2019.104249. Epub 2019 Jun 25. PMID: 31247219

Novel meriolin derivatives as rapid apoptosis inducers.
Drießen D, Stuhldreier F, Frank A, Stark H, Wesselborg S, Stork B, Müller Th. Bioorg Med Chem. 2019 Aug 1;27(15):3463-3468. doi: 10.1016/j.bmc.2019.06.029. Epub 2019 Jun 19

Publications 2018

Multiple DNA damage-dependent and DNA damage-independent stress responses define the outcome of ATR/Chk1 targeting in medulloblastoma cells.
Krüger K, Geist K, Stuhldreier F, Schumacher L, Blümel L, Remke M, Wesselborg S, Stork B, Klöcker N, Bormann S, Roos WP, Honnen S, Fritz G. Cancer Lett. 2018 Aug 28;430:34-46. doi: 10.1016/j.ca

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