Cell death, metabolic diseases and cancer ǀ UKD

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Cell death, metabolic diseases and cancer Group

Research

Role of inflammatory signalling pathways and cell death in the development of metabolic liver disease and liver cancer
Role of microRNAs in models of liver disease
microRNAs as new biomarkers in patients with gastrointestinal cancer
Biomarkers and artificial intelligence in the treatment of gastrointestinal tumours

more information...

Funding

ERC: Consolidator Grant „How cellular suicide programmes control phase transitions in fatty liver disease and liver cancer - PHASE CONTROL“, 2018-2025
BMG: Diagnosestellung und Risikostratifizierung von Lebererkrankungen mittels Deep Learning anhand von klinischen Routinedaten „DEEP LIVER“, 2020-2024
DFG: Sachbeihilfe „The role of miR-107-dependent signaling networks in hepatocarcinogenesis“, 2020-2024
DFG: Sachbeihilfe "The role of RIPK1-dependent signaling cues in chronic liver disease and hepatocellular carcinoma", 2021-2024
DFG: Sachbeihilfe "The role of A20 as a master switch for the regulation of multiple distinct cell death pathways in hepatocarcinogenesis", 2022-2024
DFG: Schwerpunktprogramm "How ferroptosis and ferroptosis-response-pathways shape the immune landscape in pancreatic ductal adenocarcinoma (PDAC)", 2021-2024
MKW: Multi-Omics Data Science (MODS) - Integrierte Datenanalyse zur Prädiktion, Prävention und Therapie metabolischer Systemstörungen MODS, 2021-2024
DFG: Clinician Scientist Programm Zukunft gestalten für Clinician Scientists in präzisionsmetabolischer Medizin, 2023-2026
BMBF: Transform Liver - Weiterentwicklung von Vision Transformern zur Entdeckung von Biomarkern bei Lebererkrankungen, 2023-2026
Deutsche Krebshilfe: DECADE - Decentralized artificial intelligence for diagnosis, prognostication and response prediction in CRC, 2023 - 2026

Team

Prof. Dr. med. Tom Lüdde, PhD

Head of research group

Publications Publons profile Twitter: @tom_luedde

PD Dr. rer. nat. Mihael Vucur

Head of research unit: cell death and inflammation

Dr. rer. nat. Anne Theres Schneider

Vice-head of research unit: cell death and inflammation

Research: Ubiquitination and deubiquitination processes in liver disease and liver cancer

Dr. rer. nat. Mirco Castoldi

Senior scientist

Dr. oec. troph. Boris Görg

Senior scientist

James Brooks, MPhys EngD

Postdoctoral researcher

Research: Application of AI to images of liver diseases for diagnosis and prognosis

Dr. rer. nat. Matthias Dille

Postdoctoral researcher

Dr. med. Tobias Seraphin

Resident / Research fellow

Doctoral candidates

Veronika Büttner

PhD candidate

Dissertation topic "Exploring the importance of the tumor microenvironment in HCC development"

Lauredana dos Santos Ferreira Grani

PhD candidate

Dissertation topic "The role of pyroptosis in alcoholic and non-alcoholic steatohepatitis"

Mika Froning

PhD candidate

Dissertation topic "The role of A20 in hepatocarcinogenesis"

Anna-Lena Hartel

PhD candidate

Dissertation topic "Role of protein O-GlcNAcylation in the growth of glutamine-auxotrophic hepatocellular tumours"

Leonie Keysberg

PhD candidate

Dissertation topic "Dissecting canonical and non-canonical NF-kB signaling in hepatocarcinogenesis"

Lena Küsgens

PhD candidate

Dissertation topic "Dissecting cell death and NF-kB in TAK1-deficient livers"

Michael Singer

PhD candidate

Dissertation topic "The role of necroptosis in obesity, NASH and metabolic disease"

Technical support

Nicole Eichhorst

Senior lab technician

Michaela Fastrich

Lab technician

Vanessa Herbertz

Lab technician

Thorsten Janssen

Lab technician

Stefanie Lindner

Lab technician

Claudia Rupprecht

Lab technician

Nathalie Walter

Lab technician

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