Publikationen

Full list of publications in  PubMed


2021

 

The pathobiology of thrombosis, microvascular disease, and hemorrhage in the myeloproliferative neoplasms. Hasselbalch HC, Elvers M, Schafer AI. Blood. 2021 Apr 22;137(16):2152-2160. doi: 10.1182/blood.2020008109. PMID: 33649757

Genetic Labeling of Cells Allows Identification and Tracking of Transgenic Platelets in Mice. Krüger I, Reusswig F, Krott KJ, Lersch CF, Spelleken M, Elvers M. Int J Mol Sci. 2021 Apr 2;22(7):3710. doi: 10.3390/ijms22073710. PMID: 33918229

 


2020

Reusswig F, Modares NF, Brechtenkamp M, et al. Efficiently restored thrombopoietin production via AMR and IL-6R induced JAK2-STAT3 signaling early after partial hepatectomy. Hepatology. 2020 Dec 28. doi: 10.1002/hep.31698. Online ahead of print. PMID: 33369745

Chatterjee M, Ehrenberg A, Toska LM, et al. Molecular Drivers of Platelet Activation: Unraveling Novel Targets for Anti-Thrombotic and Anti-Thrombo-Inflammatory Therapy. Int J Mol Sci. 2020 Oct 24;21(21):7906. doi: 10.3390/ijms21217906. PMID: 33114406

Krueger I, Gremer L, Mangels L, et al. Reelin Amplifies Glycoprotein VI Activation and AlphaIIb Beta3 Integrin Outside-In Signaling via PLC Gamma 2 and Rho GTPases. Arterioscler Thromb Vasc Biol. 2020 Oct;40(10):2391-2403. doi: 10.1161/ATVBAHA.120.314902. Epub 2020 Aug 13. PMID: 32787521

Donner L, Toska LM, Krüger I, et al. The collagen receptor glycoprotein VI promotes platelet-mediated aggregation of β-amyloid. Sci Signal. 2020 Aug 4;13(643):eaba9872. doi: 10.1126/scisignal.aba9872. PMID: 32753479

Klose AM, Klier M, Gorressen S, Elvers M, Enhanced Integrin Activation of PLD2-Deficient Platelets Accelerates Inflammation after Myocardial Infarction. Int J Mol Sci. 2020 May 1;21(9):3210. doi: 10.3390/ijms21093210. PMID: 32370031


2019

Nagy M, van Geffen JP, Stegner D, et al. Comparative Analysis of Microfluidics Thrombus Formation in Multiple Genetically Modified Mice: Link to Thrombosis and Hemostasis. Front Cardiovasc Med. 2019 Jul 30;6:99. doi: 10.3389/fcvm.2019.00099. eCollection 2019. PMID: 31417909


2018

Klier M, Gorressen S, Urbahn MA, et al. Enzymatic Activity Is Not Required for Phospholipase D Mediated TNF-α Regulation and Myocardial Healing. Front Physiol. 2018 Nov 29;9:1698. doi: 10.3389/fphys.2018.01698. eCollection 2018. PMID: 30555342

Wagenhäuser MU, Schellinger IN, Yoshino T, et al. Chronic Nicotine Exposure Induces Murine Aortic Remodeling and Stiffness Segmentation-Implications for Abdominal Aortic Aneurysm Susceptibility. Front Physiol. 2018 Oct 31;9:1459. doi: 10.3389/fphys.2018.01459. eCollection 2018. PMID: 30429794

Klatt C, Krüger I, Zey S, et al. Platelet-RBC interaction mediated by FasL/FasR induces procoagulant activity important for thrombosis. J Clin Invest. 2018 Aug 31;128(9):3906-3925. doi: 10.1172/JCI92077. Epub 2018 Aug 13. PMID: 29952767

Urbahn MA, Kaup SC, Reusswig F, et al. Phospholipase D1 regulation of TNF-alpha protects against responses to LPS. Sci Rep. 2018 Jul 3;8(1):10006. doi: 10.1038/s41598-018-28331-y. PMID: 29968773

Donner L, Gremer L, Ziehm T, et al. Relevance of N-terminal residues for amyloid-β binding to platelet integrin αIIbβ3, integrin outside-in signaling and amyloid-β fibril formation. Cell Signal. 2018 Oct;50:121-130. doi: 10.1016/j.cellsig.2018.06.015. Epub 2018 Jun 30. PMID: 29964150


2017

Gowert NS, Krüger I, Klier M, et al. Loss of Reelin protects mice against arterial thrombosis by impairing integrin activation and thrombus formation under high shear conditions. Cell Signal. 2017 Dec;40:210-221. doi: 10.1016/j.cellsig.2017.09.016. Epub 2017 Sep 21. PMID: 28943410

Klier M, Gowert NS, Jäckel S, et al. Phospholipase D1 is a regulator of platelet-mediated inflammation. Cell Signal. 2017 Oct;38:171-181. doi: 10.1016/j.cellsig.2017.07.007. Epub 2017 Jul 12. PMID: 28711718

Gowert NS, Klier M, Reich M, et al. Defective Platelet Activation and Bleeding Complications upon Cholestasis in Mice. Cell Physiol Biochem. 2017;41(6):2133-2149. doi: 10.1159/000475566. Epub 2017 Apr 20. PMID: 28441661


2016

Donner L, Fälker K, Gremer L, et al. Platelets contribute to amyloid-β aggregation in cerebral vessels through integrin αIIbβ3-induced outside-in signaling and clusterin release. Sci Signal. 2016 May 24;9(429):ra52. doi: 10.1126/scisignal.aaf6240. PMID: 27221710

Niermann C, Gorressen S, Klier M, et al. Oligophrenin1 protects mice against myocardial ischemia and reperfusion injury by modulating inflammation and myocardial apoptosis. Cell Signal. 2016 Aug;28(8):967-78. doi: 10.1016/j.cellsig.2016.04.008. Epub 2016 Apr 23. PMID: 27117132

Grandoch M, Kohlmorgen C, Melchior-Becker A, et al. Loss of Biglycan Enhances Thrombin Generation in Apolipoprotein E-Deficient Mice: Implications for Inflammation and Atherosclerosis. Arterioscler Thromb Vasc Biol. 2016 May;36(5):e41-50. doi: 10.1161/ATVBAHA.115.306973. Epub 2016 Mar 31. PMID: 27034473


2015

Elvers M. RhoGAPs and Rho GTPases in platelets. Hamostaseologie. 2016 Aug 3;36(3):168-77. doi: 10.5482/HAMO-14-09-0046. Epub 2015 Feb 2. PMID: 25639730

Fotinos A, Klier M, Gowert NS,et al. Loss of oligophrenin1 leads to uncontrolled Rho activation and increased thrombus formation in mice. J Thromb Haemost. 2015 Apr;13(4):619-30. doi: 10.1111/jth.12834. Epub 2015 Jan 29. PMID: 25556321


2014

Schonberger T, Jurgens T, Muller J, et al. Pivotal role of phospholipase D1 in tumor necrosis factor-alpha-mediated inflammation and scar formation after myocardial ischemia and reperfusion in mice. Am J Pathol. 2014;184(9):2450-2464.

Jarre A, Gowert NS, Donner L, et al. Pre-activated blood platelets and a pro-thrombotic phenotype in APP23 mice modeling Alzheimer's disease. Cell Signal. 2014;26(9):2040-2050. Prepublished on 2014/06/15 as DOI 10.1016/j.cellsig.2014.05.019. 

Gowert NS, Donner L, Chatterjee M, et al. Blood platelets in the progression of Alzheimer's disease. PLoS One. 2014;9(2):e90523. 

Borst O, Münzer P, Schmid E, et al. 1,25(OH)2 vitamin D3-dependent inhibition of platelet Ca2+ signaling and thrombus formation in klotho-deficient mice. FASEB J. 2014 May;28(5):2108-19. doi: 10.1096/fj.13-239277. Epub 2014 Feb 12. PMID: 24522202

Munzer P, Borst O, Walker B, et al. Acid sphingomyelinase regulates platelet cell membrane scrambling, secretion, and thrombus formation. Arterioscler Thromb Vasc Biol. 2014;34(1):61-71. 

Beck S, Fotinos A, Gawaz M, Elvers M. Nadrin GAP activity is isoform- and target-specific regulated by tyrosine phosphorylation. Cell Signal. 2014;26(9):1975-1984.


2013

Beck S, Fotinos A, Lang F, Gawaz M, Elvers M. Isoform-specific roles of the GTPase activating protein Nadrin in cytoskeletal reorganization of platelets. Cell Signal. 2013;25(1):236-246. 


2012

Schonberger T, Ziegler M, Borst O, et al. The dimeric platelet collagen receptor GPVI-Fc reduces platelet adhesion to activated endothelium and preserves myocardial function after transient ischemia in mice. Am J Physiol Cell Physiol. 2012;303(7):C757-766. 

Elvers M, Herrmann A, Seizer P, et al. Intracellular cyclophilin A is an important Ca(2+) regulator in platelets and critically involved in arterial thrombus formation. Blood. 2012;120(6):1317-1326. 

Elvers M, Beck S, Fotinos A, Ziegler M, Gawaz M. The GRAF family member oligophrenin1 is a RhoGAP with BAR domain and regulates Rho GTPases in platelets. Cardiovasc Res. 2012;94(3):526-536. 

Ziegler M, Elvers M, Baumer Y, et al. The bispecific SDF1-GPVI fusion protein preserves myocardial function after transient ischemia in mice. Circulation. 2012;125(5):685-696. 

Baumer Y, Leder C, Ziegler M, et al. The recombinant bifunctional protein αCD133-GPVI promotes repair of the infarcted myocardium in mice. J Thromb Haemost. 2012 Jun;10(6):1152-64. doi: 10.1111/j.1538-7836.2012.04710.x. PMID: 22448969

Elvers M, Grenegard M, Khoshjabinzadeh H, et al. A novel role for phospholipase D as an endogenous negative regulator of platelet sensitivity. Cell Signal. 2012;24(9):1743-1752. 


2011

Borst O, Schmidt EM, Münzer P, et al. The serum- and glucocorticoid-inducible kinase 1 (SGK1) influences platelet calcium signaling and function by regulation of Orai1 expression in megakaryocytes. . Blood. 2012 Jan 5;119(1):251-61. doi: 10.1182/blood-2011-06-359976. Epub 2011 Oct 26. PMID: 22031864

Bigalke B, Elvers M, Schönberger T, et al. Platelet and soluble glycoprotein VI - novel applications in diagnosis and therapy. Curr Drug Targets. 2011 Nov;12(12):1821-30. doi: 10.2174/138945011797635867. PMID: 21718237


2010

Pleines I, Eckly A, Elvers M, et al. Multiple alterations of platelet functions dominated by increased secretion in mice lacking Cdc42 in platelets. Blood. 2010;115(16):3364-3373. 

Bender M, Eckly A, Hartwig JH, et al. ADF/n-cofilin-dependent actin turnover determines platelet formation and sizing. Blood. 2010 Sep 9;116(10):1767-75. doi: 10.1182/blood-2010-03-274340. Epub 2010 Jun 7. PMID: 20530287

Elvers M, Pozgaj R, Pleines I,et al. Platelet hyperreactivity and a prothrombotic phenotype in mice with a gain-of-function mutation in phospholipase Cgamma2. J Thromb Haemost. 2010 Jun;8(6):1353-63. doi: 10.1111/j.1538-7836.2010.03838.x. Epub 2010 Mar 3. PMID: 20230420

Elvers M, Stegner D, Hagedorn I, et al. Impaired alpha(IIb)beta(3) integrin activation and shear-dependent thrombus formation in mice lacking phospholipase D1. Sci Signal. 2010;3(103):ra1.


2009

May F, Hagedorn I, Pleines I, et al. CLEC-2 is an essential platelet-activating receptor in hemostasis and thrombosis. Blood. 2009 Oct 15;114(16):3464-72. doi: 10.1182/blood-2009-05-222273. Epub 2009 Jul 29. PMID: 19641185

Pleines I, Elvers M, Strehl A, et al. Rac1 is essential for phospholipase C-gamma2 activation in platelets. Pflugers Arch. 2009;457(5):1173-1185.

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