Publikationen

Full list of publications in  PubMed


2021

The Proteoglycan Biglycan Modulates Platelet Adhesion and Thrombus Formation in a GPVI-Dependent Manner.
Hoermann H, Krueger I, Maurus N, Reusswig F, Sun Y, Kohlmorgen C, Grandoch M, Fischer JW, Elvers M.
Int J Mol Sci. 2021 Nov 10;22(22):12168. doi: 10.3390/ijms222212168. PMID: 34830059

Impact of Amyloid-β on Platelet Mitochondrial Function and Platelet-Mediated Amyloid Aggregation in Alzheimer's Disease.
Donner L, Feige T, Freiburg C, Toska LM, Reichert AS, Chatterjee M, Elvers M.
Int J Mol Sci. 2021 Sep 6;22(17):9633. doi: 10.3390/ijms22179633. PMID: 34502546

Dapagliflozin reduces thrombin generation and platelet activation: implications for cardiovascular risk reduction in type 2 diabetes mellitus.
Kohlmorgen C, Gerfer S, Feldmann K, Twarock S, Hartwig S, Lehr S, Klier M, Krüger I, Helten C, Keul P, Kahl S, Polzin A, Elvers M, Flögel U, Kelm M, Levkau B, Roden M, Fischer JW, Grandoch M.
Diabetologia. 2021 Aug;64(8):1834-1849. doi: 10.1007/s00125-021-05498-0. Epub 2021 Jun 16. PMID: 34131781

Efficiently Restored Thrombopoietin Production by Ashwell-Morell Receptor and IL-6R Induced Janus Kinase 2/Signal Transducer and Activator of Transcription Signaling Early After Partial Hepatectomy.
Reusswig F, Fazel Modares N, Brechtenkamp M, Wienands L, Krüger I, Behnke K, Lee-Sundlov MM, Herebian D, Scheller J, Hoffmeister KM, Häussinger D, Elvers M. Hepatology. 2021 Jul;74(1):411-427. doi: 10.1002/hep.31698. Epub 2021 Jun 4. PMID: 33369745

The pathobiology of thrombosis, microvascular disease, and hemorrhage in the myeloproliferative neoplasms.
Hasselbalch HC, Elvers M, Schafer AI. Blood. 2021 Apr 22;137(16):2152-2160. doi: 10.1182/blood.2020008109. PMID: 33649757

Genetic Labeling of Cells Allows Identification and Tracking of Transgenic Platelets in Mice.
Krüger I, Reusswig F, Krott KJ, Lersch CF, Spelleken M, Elvers M. Int J Mol Sci. 2021 Apr 2;22(7):3710. doi: 10.3390/ijms22073710. PMID: 33918229

 


2020

Efficiently restored thrombopoietin production via AMR and IL-6R induced JAK2-STAT3 signaling early after partial hepatectomy.
Reusswig F, Modares NF, Brechtenkamp M, et al.
Hepatology. 2020 Dec 28. doi: 10.1002/hep.31698. Online ahead of print. PMID: 33369745

Molecular Drivers of Platelet Activation: Unraveling Novel Targets for Anti-Thrombotic and Anti-Thrombo-Inflammatory Therapy.
Chatterjee M, Ehrenberg A, Toska LM, et al.
Int J Mol Sci. 2020 Oct 24;21(21):7906. doi: 10.3390/ijms21217906. PMID: 33114406

Reelin Amplifies Glycoprotein VI Activation and AlphaIIb Beta3 Integrin Outside-In Signaling via PLC Gamma 2 and Rho GTPases.
Krueger I, Gremer L, Mangels L, et al.
Arterioscler Thromb Vasc Biol. 2020 Oct;40(10):2391-2403. doi: 10.1161/ATVBAHA.120.314902. Epub 2020 Aug 13. PMID: 32787521

The collagen receptor glycoprotein VI promotes platelet-mediated aggregation of β-amyloid.
Donner L, Toska LM, Krüger I, et al.
Sci Signal. 2020 Aug 4;13(643):eaba9872. doi: 10.1126/scisignal.aba9872. PMID: 32753479

Enhanced Integrin Activation of PLD2-Deficient Platelets Accelerates Inflammation after Myocardial Infarction.
Klose AM, Klier M, Gorressen S, Elvers M
Int J Mol Sci. 2020 May 1;21(9):3210. doi: 10.3390/ijms21093210. PMID: 32370031


2019

Comparative Analysis of Microfluidics Thrombus Formation in Multiple Genetically Modified Mice: Link to Thrombosis and Hemostasis.
Nagy M, van Geffen JP, Stegner D, et al.
Front Cardiovasc Med. 2019 Jul 30;6:99. doi: 10.3389/fcvm.2019.00099. eCollection 2019. PMID: 31417909


2018

Enzymatic Activity Is Not Required for Phospholipase D Mediated TNF-α Regulation and Myocardial Healing.
Klier M, Gorressen S, Urbahn MA, et al.
Front Physiol. 2018 Nov 29;9:1698. doi: 10.3389/fphys.2018.01698. eCollection 2018. PMID: 30555342

Chronic Nicotine Exposure Induces Murine Aortic Remodeling and Stiffness Segmentation-Implications for Abdominal Aortic Aneurysm Susceptibility.
Wagenhäuser MU, Schellinger IN, Yoshino T, et al.
Front Physiol. 2018 Oct 31;9:1459. doi: 10.3389/fphys.2018.01459. eCollection 2018. PMID: 30429794

Platelet-RBC interaction mediated by FasL/FasR induces procoagulant activity important for thrombosis.
Klatt C, Krüger I, Zey S, et al.
J Clin Invest. 2018 Aug 31;128(9):3906-3925. doi: 10.1172/JCI92077. Epub 2018 Aug 13. PMID: 29952767

Phospholipase D1 regulation of TNF-alpha protects against responses to LPS.
Urbahn MA, Kaup SC, Reusswig F, et al.
Sci Rep. 2018 Jul 3;8(1):10006. doi: 10.1038/s41598-018-28331-y. PMID: 29968773

Relevance of N-terminal residues for amyloid-β binding to platelet integrin αIIbβ3, integrin outside-in signaling and amyloid-β fibril formation.
Donner L, Gremer L, Ziehm T, et al.
Cell Signal. 2018 Oct;50:121-130. doi: 10.1016/j.cellsig.2018.06.015. Epub 2018 Jun 30. PMID: 29964150


2017

Loss of Reelin protects mice against arterial thrombosis by impairing integrin activation and thrombus formation under high shear conditions.
Gowert NS, Krüger I, Klier M, et al.
Cell Signal. 2017 Dec;40:210-221. doi: 10.1016/j.cellsig.2017.09.016. Epub 2017 Sep 21. PMID: 28943410

Phospholipase D1 is a regulator of platelet-mediated inflammation.
Klier M, Gowert NS, Jäckel S, et al.
Cell Signal. 2017 Oct;38:171-181. doi: 10.1016/j.cellsig.2017.07.007. Epub 2017 Jul 12. PMID: 28711718

Defective Platelet Activation and Bleeding Complications upon Cholestasis in Mice.
Gowert NS, Klier M, Reich M, et al.
Cell Physiol Biochem. 2017;41(6):2133-2149. doi: 10.1159/000475566. Epub 2017 Apr 20. PMID: 28441661


2016

Platelets contribute to amyloid-β aggregation in cerebral vessels through integrin αIIbβ3-induced outside-in signaling and clusterin release.
Donner L, Fälker K, Gremer L, et al.
Sci Signal. 2016 May 24;9(429):ra52. doi: 10.1126/scisignal.aaf6240. PMID: 27221710

Oligophrenin1 protects mice against myocardial ischemia and reperfusion injury by modulating inflammation and myocardial apoptosis.
Niermann C, Gorressen S, Klier M, et al.
Cell Signal. 2016 Aug;28(8):967-78. doi: 10.1016/j.cellsig.2016.04.008. Epub 2016 Apr 23. PMID: 27117132

Loss of Biglycan Enhances Thrombin Generation in Apolipoprotein E-Deficient Mice: Implications for Inflammation and Atherosclerosis.
Grandoch M, Kohlmorgen C, Melchior-Becker A, et al.
Arterioscler Thromb Vasc Biol. 2016 May;36(5):e41-50. doi: 10.1161/ATVBAHA.115.306973. Epub 2016 Mar 31. PMID: 27034473


2015

RhoGAPs and Rho GTPases in platelets.
Elvers M. 
Hamostaseologie. 2016 Aug 3;36(3):168-77. doi: 10.5482/HAMO-14-09-0046. Epub 2015 Feb 2. PMID: 25639730

Loss of oligophrenin1 leads to uncontrolled Rho activation and increased thrombus formation in mice.
Fotinos A, Klier M, Gowert NS,et al.
J Thromb Haemost. 2015 Apr;13(4):619-30. doi: 10.1111/jth.12834. Epub 2015 Jan 29. PMID: 25556321


2014

Pivotal role of phospholipase D1 in tumor necrosis factor-alpha-mediated inflammation and scar formation after myocardial ischemia and reperfusion in mice.
Schonberger T, Jurgens T, Muller J, et al.
Am J Pathol. 2014;184(9):2450-2464.

Pre-activated blood platelets and a pro-thrombotic phenotype in APP23 mice modeling Alzheimer's disease.
Jarre A, Gowert NS, Donner L, et al.
Cell Signal. 2014;26(9):2040-2050. Prepublished on 2014/06/15 as DOI 10.1016/j.cellsig.2014.05.019. 

Blood platelets in the progression of Alzheimer's disease.
Gowert NS, Donner L, Chatterjee M, et al.
PLoS One. 2014;9(2):e90523. 

1,25(OH)2 vitamin D3-dependent inhibition of platelet Ca2+ signaling and thrombus formation in klotho-deficient mice.
Borst O, Münzer P, Schmid E, et al.
FASEB J. 2014 May;28(5):2108-19. doi: 10.1096/fj.13-239277. Epub 2014 Feb 12. PMID: 24522202

Acid sphingomyelinase regulates platelet cell membrane scrambling, secretion, and thrombus formation.
Munzer P, Borst O, Walker B, et al.
Arterioscler Thromb Vasc Biol. 2014;34(1):61-71. 

Nadrin GAP activity is isoform- and target-specific regulated by tyrosine phosphorylation.
Beck S, Fotinos A, Gawaz M, Elvers M.
Cell Signal. 2014;26(9):1975-1984.


2013

Isoform-specific roles of the GTPase activating protein Nadrin in cytoskeletal reorganization of platelets.
Beck S, Fotinos A, Lang F, Gawaz M, Elvers M.
Cell Signal. 2013;25(1):236-246. 


2012

The dimeric platelet collagen receptor GPVI-Fc reduces platelet adhesion to activated endothelium and preserves myocardial function after transient ischemia in mice.
Schonberger T, Ziegler M, Borst O, et al.
Am J Physiol Cell Physiol. 2012;303(7):C757-766. 

Intracellular cyclophilin A is an important Ca(2+) regulator in platelets and critically involved in arterial thrombus formation.
Elvers M, Herrmann A, Seizer P, et al.
Blood. 2012;120(6):1317-1326. 

The GRAF family member oligophrenin1 is a RhoGAP with BAR domain and regulates Rho GTPases in platelets.
Elvers M, Beck S, Fotinos A, Ziegler M, Gawaz M.
Cardiovasc Res. 2012;94(3):526-536. 

The bispecific SDF1-GPVI fusion protein preserves myocardial function after transient ischemia in mice.
Ziegler M, Elvers M, Baumer Y, et al.
Circulation. 2012;125(5):685-696. 

The recombinant bifunctional protein αCD133-GPVI promotes repair of the infarcted myocardium in mice.
Baumer Y, Leder C, Ziegler M, et al.
J Thromb Haemost. 2012 Jun;10(6):1152-64. doi: 10.1111/j.1538-7836.2012.04710.x. PMID: 22448969

A novel role for phospholipase D as an endogenous negative regulator of platelet sensitivity.
Elvers M, Grenegard M, Khoshjabinzadeh H, et al.
Cell Signal. 2012;24(9):1743-1752. 


2011

The serum- and glucocorticoid-inducible kinase 1 (SGK1) influences platelet calcium signaling and function by regulation of Orai1 expression in megakaryocytes.
Borst O, Schmidt EM, Münzer P, et al.
Blood. 2012 Jan 5;119(1):251-61. doi: 10.1182/blood-2011-06-359976. Epub 2011 Oct 26. PMID: 22031864

Platelet and soluble glycoprotein VI - novel applications in diagnosis and therapy.
Bigalke B, Elvers M, Schönberger T, et al.
Curr Drug Targets. 2011 Nov;12(12):1821-30. doi: 10.2174/138945011797635867. PMID: 21718237


2010

Multiple alterations of platelet functions dominated by increased secretion in mice lacking Cdc42 in platelets.
Pleines I, Eckly A, Elvers M, et al.
Blood. 2010;115(16):3364-3373. 

ADF/n-cofilin-dependent actin turnover determines platelet formation and sizing.
Bender M, Eckly A, Hartwig JH, et al.
Blood. 2010 Sep 9;116(10):1767-75. doi: 10.1182/blood-2010-03-274340. Epub 2010 Jun 7. PMID: 20530287

Platelet hyperreactivity and a prothrombotic phenotype in mice with a gain-of-function mutation in phospholipase Cgamma2.
Elvers M, Pozgaj R, Pleines I,et al.
J Thromb Haemost. 2010 Jun;8(6):1353-63. doi: 10.1111/j.1538-7836.2010.03838.x. Epub 2010 Mar 3. PMID: 20230420

Impaired alpha(IIb)beta(3) integrin activation and shear-dependent thrombus formation in mice lacking phospholipase D1.
Elvers M, Stegner D, Hagedorn I, et al.
Sci Signal. 2010;3(103):ra1.


2009

CLEC-2 is an essential platelet-activating receptor in hemostasis and thrombosis.
May F, Hagedorn I, Pleines I, et al.
Blood. 2009 Oct 15;114(16):3464-72. doi: 10.1182/blood-2009-05-222273. Epub 2009 Jul 29. PMID: 19641185

Rac1 is essential for phospholipase C-gamma2 activation in platelets.
Pleines I, Elvers M, Strehl A, et al.
Pflugers Arch. 2009;457(5):1173-1185.

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