Publikationen
Full list of publications in PubMed
2023
Flow Chamber Analyses in Cardiovascular Research: Impact of Platelets and the Intercellular Crosstalk with Endothelial Cells, Leukocytes, and Red Blood Cells.
Krott KJ, Feige T, Elvers M.
Hamostaseologie. 2023 Oct;43(5):338-347. doi: 10.1055/a-2113-1134. Epub 2023 Oct 19. PMID: 37857296
Ethanol Enhances Endothelial Rigidity by Targeting VE-Cadherin-Implications for Acute Aortic Dissection.
Mulorz J, Ibing W, Cappallo M, Braß SM, Takeuchi K, Raaz U, Schellinger IN, Krott KJ, Schelzig H, Aubin H, Oberhuber A, Elvers M, Wagenhäuser MU.
J Clin Med. 2023 Jul 28;12(15):4967. doi: 10.3390/jcm12154967. PMID: 37568369
Constitutive Activation of gp130 in T Cells Results in Senescence and Premature Aging.
Rafii P, Reusswig F, Werner J, Xu H, Lang PA, Rose-John S, Gorressen S, Alter C, Schrader J, Herebian D, Floss DM, Elvers M, Piekorz RP, Scheller J, Behnke K.
J Immunol. 2023 Jun 1;210(11):1641-1652. doi: 10.4049/jimmunol.2200788. PMID: 37058108
The NMDA receptor regulates integrin activation, ATP release and arterial thrombosis through store-operated Ca2+ entry in platelets.
Reusswig F, Yilmaz M, Brechtenkamp M, Krueger I, Metz LM, Klöcker N, Lammert E, Elvers M. Front Cardiovasc Med. 2023 May 12;10:1171831. doi: 10.3389/fcvm.2023.1171831. eCollection 2023. PMID: 37252113
Platelet pannexin-1 channels modulate neutrophil activation and migration but not the progression of abdominal aortic aneurysm.
Metz LM, Feige T, de Biasi L, Ehrenberg A, Mulorz J, Toska LM, Reusswig F, Quast C, Gerdes N, Kelm M, Schelzig H, Elvers M.
Front Mol Biosci. 2023 Mar 6;10:1111108. doi: 10.3389/fmolb.2023.1111108. eCollection 2023. PMID: 36950521
Minimal Collagen-Binding Epitope of Glycoprotein VI in Human and Mouse Platelets.
Han C, Ren P, Mamtimin M, Kruk L, Sarukhanyan E, Li C, Anders HJ, Dandekar T, Krueger I, Elvers M, Goebel S, Adler K, Münch G, Gudermann T, Braun A, Mammadova-Bach E.
Biomedicines. 2023 Feb 1;11(2):423. doi: 10.3390/biomedicines11020423. PMID: 36830959
2022
2021
The Proteoglycan Biglycan Modulates Platelet Adhesion and Thrombus Formation in a GPVI-Dependent Manner.
Hoermann H, Krueger I, Maurus N, Reusswig F, Sun Y, Kohlmorgen C, Grandoch M, Fischer JW, Elvers M.
Int J Mol Sci. 2021 Nov 10;22(22):12168. doi: 10.3390/ijms222212168. PMID: 34830059
Impact of Amyloid-β on Platelet Mitochondrial Function and Platelet-Mediated Amyloid Aggregation in Alzheimer's Disease.
Donner L, Feige T, Freiburg C, Toska LM, Reichert AS, Chatterjee M, Elvers M.
Int J Mol Sci. 2021 Sep 6;22(17):9633. doi: 10.3390/ijms22179633. PMID: 34502546
Dapagliflozin reduces thrombin generation and platelet activation: implications for cardiovascular risk reduction in type 2 diabetes mellitus.
Kohlmorgen C, Gerfer S, Feldmann K, Twarock S, Hartwig S, Lehr S, Klier M, Krüger I, Helten C, Keul P, Kahl S, Polzin A, Elvers M, Flögel U, Kelm M, Levkau B, Roden M, Fischer JW, Grandoch M.
Diabetologia. 2021 Aug;64(8):1834-1849. doi: 10.1007/s00125-021-05498-0. Epub 2021 Jun 16. PMID: 34131781
Efficiently Restored Thrombopoietin Production by Ashwell-Morell Receptor and IL-6R Induced Janus Kinase 2/Signal Transducer and Activator of Transcription Signaling Early After Partial Hepatectomy.
Reusswig F, Fazel Modares N, Brechtenkamp M, Wienands L, Krüger I, Behnke K, Lee-Sundlov MM, Herebian D, Scheller J, Hoffmeister KM, Häussinger D, Elvers M. Hepatology. 2021 Jul;74(1):411-427. doi: 10.1002/hep.31698. Epub 2021 Jun 4. PMID: 33369745
The pathobiology of thrombosis, microvascular disease, and hemorrhage in the myeloproliferative neoplasms.
Hasselbalch HC, Elvers M, Schafer AI. Blood. 2021 Apr 22;137(16):2152-2160. doi: 10.1182/blood.2020008109. PMID: 33649757
Genetic Labeling of Cells Allows Identification and Tracking of Transgenic Platelets in Mice.
Krüger I, Reusswig F, Krott KJ, Lersch CF, Spelleken M, Elvers M. Int J Mol Sci. 2021 Apr 2;22(7):3710. doi: 10.3390/ijms22073710. PMID: 33918229
2020
Reusswig F, Modares NF, Brechtenkamp M, et al. Efficiently restored thrombopoietin production via AMR and IL-6R induced JAK2-STAT3 signaling early after partial hepatectomy. Hepatology. 2020 Dec 28. doi: 10.1002/hep.31698. Online ahead of print. PMID: 33369745
Chatterjee M, Ehrenberg A, Toska LM, et al. Molecular Drivers of Platelet Activation: Unraveling Novel Targets for Anti-Thrombotic and Anti-Thrombo-Inflammatory Therapy. Int J Mol Sci. 2020 Oct 24;21(21):7906. doi: 10.3390/ijms21217906. PMID: 33114406
Krueger I, Gremer L, Mangels L, et al. Reelin Amplifies Glycoprotein VI Activation and AlphaIIb Beta3 Integrin Outside-In Signaling via PLC Gamma 2 and Rho GTPases. Arterioscler Thromb Vasc Biol. 2020 Oct;40(10):2391-2403. doi: 10.1161/ATVBAHA.120.314902. Epub 2020 Aug 13. PMID: 32787521
Donner L, Toska LM, Krüger I, et al. The collagen receptor glycoprotein VI promotes platelet-mediated aggregation of β-amyloid. Sci Signal. 2020 Aug 4;13(643):eaba9872. doi: 10.1126/scisignal.aba9872. PMID: 32753479
Klose AM, Klier M, Gorressen S, Elvers M, Enhanced Integrin Activation of PLD2-Deficient Platelets Accelerates Inflammation after Myocardial Infarction. Int J Mol Sci. 2020 May 1;21(9):3210. doi: 10.3390/ijms21093210. PMID: 32370031
2019
Nagy M, van Geffen JP, Stegner D, et al. Comparative Analysis of Microfluidics Thrombus Formation in Multiple Genetically Modified Mice: Link to Thrombosis and Hemostasis. Front Cardiovasc Med. 2019 Jul 30;6:99. doi: 10.3389/fcvm.2019.00099. eCollection 2019. PMID: 31417909
2018
Klier M, Gorressen S, Urbahn MA, et al. Enzymatic Activity Is Not Required for Phospholipase D Mediated TNF-α Regulation and Myocardial Healing. Front Physiol. 2018 Nov 29;9:1698. doi: 10.3389/fphys.2018.01698. eCollection 2018. PMID: 30555342
Wagenhäuser MU, Schellinger IN, Yoshino T, et al. Chronic Nicotine Exposure Induces Murine Aortic Remodeling and Stiffness Segmentation-Implications for Abdominal Aortic Aneurysm Susceptibility. Front Physiol. 2018 Oct 31;9:1459. doi: 10.3389/fphys.2018.01459. eCollection 2018. PMID: 30429794
Klatt C, Krüger I, Zey S, et al. Platelet-RBC interaction mediated by FasL/FasR induces procoagulant activity important for thrombosis. J Clin Invest. 2018 Aug 31;128(9):3906-3925. doi: 10.1172/JCI92077. Epub 2018 Aug 13. PMID: 29952767
Urbahn MA, Kaup SC, Reusswig F, et al. Phospholipase D1 regulation of TNF-alpha protects against responses to LPS. Sci Rep. 2018 Jul 3;8(1):10006. doi: 10.1038/s41598-018-28331-y. PMID: 29968773
Donner L, Gremer L, Ziehm T, et al. Relevance of N-terminal residues for amyloid-β binding to platelet integrin αIIbβ3, integrin outside-in signaling and amyloid-β fibril formation. Cell Signal. 2018 Oct;50:121-130. doi: 10.1016/j.cellsig.2018.06.015. Epub 2018 Jun 30. PMID: 29964150
2017
Gowert NS, Krüger I, Klier M, et al. Loss of Reelin protects mice against arterial thrombosis by impairing integrin activation and thrombus formation under high shear conditions. Cell Signal. 2017 Dec;40:210-221. doi: 10.1016/j.cellsig.2017.09.016. Epub 2017 Sep 21. PMID: 28943410
Klier M, Gowert NS, Jäckel S, et al. Phospholipase D1 is a regulator of platelet-mediated inflammation. Cell Signal. 2017 Oct;38:171-181. doi: 10.1016/j.cellsig.2017.07.007. Epub 2017 Jul 12. PMID: 28711718
Gowert NS, Klier M, Reich M, et al. Defective Platelet Activation and Bleeding Complications upon Cholestasis in Mice. Cell Physiol Biochem. 2017;41(6):2133-2149. doi: 10.1159/000475566. Epub 2017 Apr 20. PMID: 28441661
2016
Donner L, Fälker K, Gremer L, et al. Platelets contribute to amyloid-β aggregation in cerebral vessels through integrin αIIbβ3-induced outside-in signaling and clusterin release. Sci Signal. 2016 May 24;9(429):ra52. doi: 10.1126/scisignal.aaf6240. PMID: 27221710
Niermann C, Gorressen S, Klier M, et al. Oligophrenin1 protects mice against myocardial ischemia and reperfusion injury by modulating inflammation and myocardial apoptosis. Cell Signal. 2016 Aug;28(8):967-78. doi: 10.1016/j.cellsig.2016.04.008. Epub 2016 Apr 23. PMID: 27117132
Grandoch M, Kohlmorgen C, Melchior-Becker A, et al. Loss of Biglycan Enhances Thrombin Generation in Apolipoprotein E-Deficient Mice: Implications for Inflammation and Atherosclerosis. Arterioscler Thromb Vasc Biol. 2016 May;36(5):e41-50. doi: 10.1161/ATVBAHA.115.306973. Epub 2016 Mar 31. PMID: 27034473
2015
Elvers M. RhoGAPs and Rho GTPases in platelets. Hamostaseologie. 2016 Aug 3;36(3):168-77. doi: 10.5482/HAMO-14-09-0046. Epub 2015 Feb 2. PMID: 25639730
Fotinos A, Klier M, Gowert NS,et al. Loss of oligophrenin1 leads to uncontrolled Rho activation and increased thrombus formation in mice. J Thromb Haemost. 2015 Apr;13(4):619-30. doi: 10.1111/jth.12834. Epub 2015 Jan 29. PMID: 25556321
2014
Schonberger T, Jurgens T, Muller J, et al. Pivotal role of phospholipase D1 in tumor necrosis factor-alpha-mediated inflammation and scar formation after myocardial ischemia and reperfusion in mice. Am J Pathol. 2014;184(9):2450-2464.
Jarre A, Gowert NS, Donner L, et al. Pre-activated blood platelets and a pro-thrombotic phenotype in APP23 mice modeling Alzheimer's disease. Cell Signal. 2014;26(9):2040-2050. Prepublished on 2014/06/15 as DOI 10.1016/j.cellsig.2014.05.019.
Gowert NS, Donner L, Chatterjee M, et al. Blood platelets in the progression of Alzheimer's disease. PLoS One. 2014;9(2):e90523.
Borst O, Münzer P, Schmid E, et al. 1,25(OH)2 vitamin D3-dependent inhibition of platelet Ca2+ signaling and thrombus formation in klotho-deficient mice. FASEB J. 2014 May;28(5):2108-19. doi: 10.1096/fj.13-239277. Epub 2014 Feb 12. PMID: 24522202
Munzer P, Borst O, Walker B, et al. Acid sphingomyelinase regulates platelet cell membrane scrambling, secretion, and thrombus formation. Arterioscler Thromb Vasc Biol. 2014;34(1):61-71.
Beck S, Fotinos A, Gawaz M, Elvers M. Nadrin GAP activity is isoform- and target-specific regulated by tyrosine phosphorylation. Cell Signal. 2014;26(9):1975-1984.
2013
Beck S, Fotinos A, Lang F, Gawaz M, Elvers M. Isoform-specific roles of the GTPase activating protein Nadrin in cytoskeletal reorganization of platelets. Cell Signal. 2013;25(1):236-246.
2012
Schonberger T, Ziegler M, Borst O, et al. The dimeric platelet collagen receptor GPVI-Fc reduces platelet adhesion to activated endothelium and preserves myocardial function after transient ischemia in mice. Am J Physiol Cell Physiol. 2012;303(7):C757-766.
Elvers M, Herrmann A, Seizer P, et al. Intracellular cyclophilin A is an important Ca(2+) regulator in platelets and critically involved in arterial thrombus formation. Blood. 2012;120(6):1317-1326.
Elvers M, Beck S, Fotinos A, Ziegler M, Gawaz M. The GRAF family member oligophrenin1 is a RhoGAP with BAR domain and regulates Rho GTPases in platelets. Cardiovasc Res. 2012;94(3):526-536.
Ziegler M, Elvers M, Baumer Y, et al. The bispecific SDF1-GPVI fusion protein preserves myocardial function after transient ischemia in mice. Circulation. 2012;125(5):685-696.
Baumer Y, Leder C, Ziegler M, et al. The recombinant bifunctional protein αCD133-GPVI promotes repair of the infarcted myocardium in mice. J Thromb Haemost. 2012 Jun;10(6):1152-64. doi: 10.1111/j.1538-7836.2012.04710.x. PMID: 22448969
Elvers M, Grenegard M, Khoshjabinzadeh H, et al. A novel role for phospholipase D as an endogenous negative regulator of platelet sensitivity. Cell Signal. 2012;24(9):1743-1752.
2011
Borst O, Schmidt EM, Münzer P, et al. The serum- and glucocorticoid-inducible kinase 1 (SGK1) influences platelet calcium signaling and function by regulation of Orai1 expression in megakaryocytes. . Blood. 2012 Jan 5;119(1):251-61. doi: 10.1182/blood-2011-06-359976. Epub 2011 Oct 26. PMID: 22031864
Bigalke B, Elvers M, Schönberger T, et al. Platelet and soluble glycoprotein VI - novel applications in diagnosis and therapy. Curr Drug Targets. 2011 Nov;12(12):1821-30. doi: 10.2174/138945011797635867. PMID: 21718237
2010
Pleines I, Eckly A, Elvers M, et al. Multiple alterations of platelet functions dominated by increased secretion in mice lacking Cdc42 in platelets. Blood. 2010;115(16):3364-3373.
Bender M, Eckly A, Hartwig JH, et al. ADF/n-cofilin-dependent actin turnover determines platelet formation and sizing. Blood. 2010 Sep 9;116(10):1767-75. doi: 10.1182/blood-2010-03-274340. Epub 2010 Jun 7. PMID: 20530287
Elvers M, Pozgaj R, Pleines I,et al. Platelet hyperreactivity and a prothrombotic phenotype in mice with a gain-of-function mutation in phospholipase Cgamma2. J Thromb Haemost. 2010 Jun;8(6):1353-63. doi: 10.1111/j.1538-7836.2010.03838.x. Epub 2010 Mar 3. PMID: 20230420
Elvers M, Stegner D, Hagedorn I, et al. Impaired alpha(IIb)beta(3) integrin activation and shear-dependent thrombus formation in mice lacking phospholipase D1. Sci Signal. 2010;3(103):ra1.
2009
May F, Hagedorn I, Pleines I, et al. CLEC-2 is an essential platelet-activating receptor in hemostasis and thrombosis. Blood. 2009 Oct 15;114(16):3464-72. doi: 10.1182/blood-2009-05-222273. Epub 2009 Jul 29. PMID: 19641185
Pleines I, Elvers M, Strehl A, et al. Rac1 is essential for phospholipase C-gamma2 activation in platelets. Pflugers Arch. 2009;457(5):1173-1185.