Arrhythmia and Neuro-Cardiology Working Group

Our research group focuses on cutting-edge interventional approaches in cardiac electrophysiology, combining technical innovation with deep mechanistic insight into complex arrhythmias and device therapies. The field of rhythmology is currently experiencing one of the most exciting periods of transformation – driven by technological advances, evolving pathophysiological concepts, and the growing need for truly individualized care.

A major research focus lies in atrial fibrillation (AF) ablation, where we explore and implement both established techniques and emerging modalities such as pulsed field ablation (PFA). As a non-thermal energy source with high myocardial selectivity and a favorable safety profile, PFA represents a major paradigm shift in AF treatment – and our team is actively involved in both clinical trials and real-world implementation studies.

Beyond conventional ablation, we specialize in cardioneuroablation – a novel, highly targeted therapy for patients suffering from functional bradycardia, neurocardiogenic syncope, and vagally mediated atrial fibrillation. By modulating autonomic input via ablation of ganglionated plexi and parasympathetic fibers, cardioneuroablation opens an exciting new avenue for autonomic modulation in patients with limited therapeutic options. We are currently conducting mechanistic and clinical research to define the best candidates, procedural endpoints, and long-term outcomes.

Another frontier of our research is transcoronary ethanol ablation, reserved for the most challenging cases of scar-related ventricular tachycardia (VT) or intramural arrhythmic foci not accessible by conventional endocardial or epicardial approaches. This technique allows selective destruction of arrhythmogenic tissue via targeted injection into the coronary circulation, and requires the highest level of interdisciplinary coordination, imaging precision, and procedural skill. Our group contributes to the refinement of this therapy and its integration into multi-modality VT management.

In the field of device therapy, we lead a high-volume program for complex lead extraction and leadless device implantation. Our expertise includes advanced laser- and mechanical sheath systems, management of device-related infections, and the implementation of conduction system pacing (His-bundle and left bundle branch pacing). These techniques are rapidly reshaping the future of bradycardia and resynchronization therapy, and our research efforts aim to expand their applicability and optimize long-term outcomes.

We offer an intellectually vibrant and technically advanced environment for doctoral students, MD candidates, and clinician-scientists looking to specialize in arrhythmia research and therapy. Our projects range from translational studies in neuro-cardiac interaction and myocardial fibrosis to multicenter clinical trials on ablation efficacy and device safety.

Please feel free to reach out to PD Dr. med. Obaida Rana if you are interested in joining a passionate and interdisciplinary team at the forefront of rhythmology research.