Main research topics

• Inflammation and myocardial adaption in aortic valve stenosis
• Endothelial dysfunction and cardioprotection in hyperinsulinemia

Current projects

• Role of purinergic signaling in aortic valve stenosis
• MRI-based characterisation of myocardial adaption in experimental aortic valve stenosis

Collaborations

• Prof. Dr. med. J. Schrader (Department of Molecular Cardiology, Düsseldorf)

Selected publications

• Quast C, Alter C, Ding Z, Borg N, Schrader J. Adenosine Formed by CD73 on T Cells Inhibits Cardiac Inflammation and Fibrosis and Preserves Contractile Function in Transverse Aortic Constriction-Induced Heart Failure. Circ Heart Fail. (2017);10(4). pii: e003346. doi: 10.1161/CIRCHEARTFAILURE.116.003346.
• Borg N, Alter C, Görldt N, Jacoby C, Ding Z, Steckel B, Quast C, Bönner F, Friebe D, Temme S, Flögel U, Schrader J. CD73 on T-Cells Orchestrates Cardiac Wound Healing After Myocardial Infarction by Purinergic Metabolic Reprogramming. Circulation (2017);136(3):297-313.
• Ding Z, Temme S, Quast C, Friebe D, Jacoby C, Zanger K, Bidmon HJ, Grapentin C, Schubert R, Flögel U, Schrader J. Epicardium-Derived Cells Formed After Myocardial Injury Display Phagocytic Activity Permitting In Vivo Labeling and Tracking. Stem Cells Transl Med. (2016);5(5):639-50.
• Temme S, Grapentin C, Quast C, Jacoby C, Grandoch M, Ding Z, Owenier C, Mayenfels F, Fischer JW, Schubert R, Schrader J, Flögel U. Noninvasive Imaging of Early Venous Thrombosis by 19F Magnetic Resonance Imaging With Targeted Perfluorocarbon Nanoemulsions. Circulation. (2015);131(16):1405-14.